neuropeptides

Summary

Summary: Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.

Top Publications

  1. doi Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, D 68159 Mannheim, Germany
    Nat Rev Neurosci 12:524-38. 2011
  2. pmc The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    Yasemin Sancak
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology MIT, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 320:1496-501. 2008
  3. ncbi Neuronal replacement from endogenous precursors in the adult brain after stroke
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Nat Med 8:963-70. 2002
  4. ncbi Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons
    F Francis
    U129 de l INSERM, Institut Cochin de Genetique Moleculaire, Paris
    Neuron 23:247-56. 1999
  5. ncbi Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    T Sakurai
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 92:573-85. 1998
  6. ncbi Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons
    J G Gleeson
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Neuron 23:257-71. 1999
  7. pmc Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    Ken Inoki
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1829-34. 2003
  8. pmc Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search
    Cory M Root
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 145:133-44. 2011
  9. doi Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis
    Dirk Jan Saaltink
    Department of Medical Pharmacology, Leiden University Medical Center, P O Box 9503, 2300 RA, Leiden, The Netherlands
    J Comp Neurol 520:2805-23. 2012
  10. ncbi Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    R M Chemelli
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 98:437-51. 1999

Detail Information

Publications385 found, 100 shown here

  1. doi Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, D 68159 Mannheim, Germany
    Nat Rev Neurosci 12:524-38. 2011
    The neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are evolutionarily highly conserved mediators in the regulation of complex social cognition and behaviour...
  2. pmc The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    Yasemin Sancak
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology MIT, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 320:1496-501. 2008
    ..The Rag proteins do not directly stimulate the kinase activity of mTORC1, but, like amino acids, promote the intracellular localization of mTOR to a compartment that also contains its activator Rheb...
  3. ncbi Neuronal replacement from endogenous precursors in the adult brain after stroke
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Nat Med 8:963-70. 2002
    ..If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans...
  4. ncbi Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons
    F Francis
    U129 de l INSERM, Institut Cochin de Genetique Moleculaire, Paris
    Neuron 23:247-56. 1999
    ..Our data suggest that the cortical dysgeneses associated with the loss of Doublecortin function might result from abnormal cytoskeletal dynamics in neuronal cell development...
  5. ncbi Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    T Sakurai
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 92:573-85. 1998
    ..We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (..
  6. ncbi Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons
    J G Gleeson
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Neuron 23:257-71. 1999
    ..Therefore, DCX likely directs neuronal migration by regulating the organization and stability of microtubules...
  7. pmc Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    Ken Inoki
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1829-34. 2003
    ..Our data demonstrate that Rheb acts downstream of TSC1/TSC2 and upstream of mTOR to regulate cell growth...
  8. pmc Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search
    Cory M Root
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 145:133-44. 2011
    ..Thus, starvation increases expression of sNPFR1 to change the odor map, resulting in more robust food-search behavior...
  9. doi Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis
    Dirk Jan Saaltink
    Department of Medical Pharmacology, Leiden University Medical Center, P O Box 9503, 2300 RA, Leiden, The Netherlands
    J Comp Neurol 520:2805-23. 2012
    ..In addition, we propose unique roles for DCL in adult neurogenesis and we suggest high levels of neuronal plasticity in tanycytes, SCN, and ICj...
  10. ncbi Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    R M Chemelli
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 98:437-51. 1999
    ..We propose that orexin regulates sleep/wakefulness states, and that orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation...
  11. ncbi Arousal and reward: a dichotomy in orexin function
    Glenda C Harris
    Department of Psychiatry, University of Pennsylvania, Translational Research Labs 3403, 125 South 31st Street, Philadelphia, PA 19104, USA
    Trends Neurosci 29:571-7. 2006
    ..Evidence also indicates roles for lateral hypothalamus orexin neurons and ventral tegmental orexin receptors in reward-based learning and memory...
  12. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  13. ncbi Neural substrates of awakening probed with optogenetic control of hypocretin neurons
    Antoine R Adamantidis
    Department of Psychiatry and Behavioral Sciences, Stanford University, 701B Welch Road, Palo Alto, California 94304, USA
    Nature 450:420-4. 2007
    ..This study establishes a causal relationship between frequency-dependent activity of a genetically defined neural cell type and a specific mammalian behaviour central to clinical conditions and neurobehavioural physiology...
  14. ncbi Distribution of orexin neurons in the adult rat brain
    T Nambu
    Institute of Basic Medical Sciences, University of Tsukuba, 1 1, Tennohdai, Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Brain Res 827:243-60. 1999
    Orexin (ORX)-A and -B are recently identified neuropeptides, which are specifically localized in neurons within and around the lateral hypothalamic area (LHA) and dorsomedial hypothalamic nucleus (DMH), the regions classically implicated ..
  15. ncbi A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    C Peyron
    Center for Narcolepsy, Stanford University Medical School 1201 Welch Road, Stanford, California 94305 5485, USA
    Nat Med 6:991-7. 2000
    ..Although hypocretin loci do not contribute significantly to genetic predisposition, most cases of human narcolepsy are associated with a deficient hypocretin system...
  16. ncbi Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects
    S T Sweeney
    Department of Genetics, University of Cambridge, England
    Neuron 14:341-51. 1995
    ..Targeted expression of toxin can produce specific behavioral defects; in one case, the olfactory escape response is reduced...
  17. doi Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal
    Takeshi Sakurai
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Trends Pharmacol Sci 32:451-62. 2011
    ..We will also examine connections between orexin neurons and other brain areas involved in feeding behavior, reward and emotion. Finally, we will consider the therapeutic potential of drugs that target orexin receptors...
  18. doi Drosophila neuropeptides in regulation of physiology and behavior
    Dick R Nassel
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    Prog Neurobiol 92:42-104. 2010
    ..A large number of different neuropeptides has been identified in a huge variety of neuron types in different parts of the Drosophila nervous system and ..
  19. pmc Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
    Takahiro Nobukuni
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Proc Natl Acad Sci U S A 102:14238-43. 2005
    ....
  20. ncbi Doublecortin expression levels in adult brain reflect neurogenesis
    Sebastien Couillard-Despres
    Volkswagen Foundation Junior Group, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Eur J Neurosci 21:1-14. 2005
    ....
  21. ncbi Behavioral correlates of activity in identified hypocretin/orexin neurons
    Boris Y Mileykovskiy
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA
    Neuron 46:787-98. 2005
    ..Our findings suggest that these cells are activated during emotional and sensorimotor conditions similar to those that trigger cataplexy in narcoleptic animals...
  22. pmc The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
    L de Lecea
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 95:322-7. 1998
    ..One of the Hcrt peptides was excitatory when applied to cultured, synaptically coupled hypothalamic neurons, but not hippocampal neurons. These observations suggest that the hypocretins function within the CNS as neurotransmitters...
  23. ncbi The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats
    D C Piper
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Eur J Neurosci 12:726-30. 2000
    ....
  24. pmc Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice
    Tomomi Tsunematsu
    Division of Cell Signaling, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    J Neurosci 31:10529-39. 2011
    ..The results presented here advance our understanding of the role of orexin neurons in the regulation of sleep/wakefulness and may be relevant to the mechanisms that underlie symptom progression in narcolepsy...
  25. ncbi Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis
    H Chen
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 394:793-7. 1998
    ..We propose that epsin may participate, together with Eps15, in the molecular rearrangement of the clathrin coats that are required for coated-pit invagination and vesicle fission...
  26. pmc Neurexin-neuroligin signaling in synapse development
    Ann Marie Craig
    Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 2B5, Canada
    Curr Opin Neurobiol 17:43-52. 2007
    ....
  27. pmc Novel embryonic neuronal migration and proliferation defects in Dcx mutant mice are exacerbated by Lis1 reduction
    Tiziano Pramparo
    Department of Pediatrics, University of California, San Francisco, School of Medicine, San Francisco, California 94143 0794, USA
    J Neurosci 30:3002-12. 2010
    ..Thus, we provide definitive evidence for a critical role for Dcx in neuronal migration and neurogenesis, as well as for the in vivo genetic interaction of the two genes most commonly involved in human neuronal migration defects...
  28. ncbi Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
    Maan Gee Lee
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    J Neurosci 25:6716-20. 2005
    ..They increase firing before the end of PS and thereby herald by several seconds the return of waking and muscle tone. The orexin neurons would thus stimulate arousal, while antagonizing sleep and muscle atonia...
  29. ncbi Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling
    Elizabeth S Maywood
    MRC Laboratory of Molecular Biology, Neurobiology Division, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 16:599-605. 2006
    ..Hence, neuropeptidergic interneuronal signaling confers a canonical property upon the SCN: spontaneous synchronization of the intracellular molecular clockworks of individual neurons...
  30. ncbi Acid-sensing ion channels in sensory perception
    Eric Lingueglia
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS Université de Nice Sophia Antipolis UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 282:17325-9. 2007
  31. ncbi Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum
    Toru Yamashita
    Bridgestone Laboratory of Developmental and Regenerative Neurobiology, Keio University School of Medicine, Shinanomachi, Tokyo 160 8582, Japan
    J Neurosci 26:6627-36. 2006
    ..These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders...
  32. pmc Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution
    Yoonseong Park
    Department of Entomology, 5429 Boyce Hall, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 99:11423-8. 2002
    ..These findings support a theory of coevolution for NMU and Drosophila PRXa peptides and their respective receptors...
  33. ncbi Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects
    Yan Ling Xu
    Department of Pharmacology, University of California Irvine, Irvine, Irvine, California 92697, USA
    Neuron 43:487-97. 2004
    ..These results indicate that NPS could be a new modulator of arousal and anxiety. They also show that the LC region encompasses distinct nuclei expressing different arousal-promoting neurotransmitters...
  34. doi A comparative review of short and long neuropeptide F signaling in invertebrates: Any similarities to vertebrate neuropeptide Y signaling?
    Dick R Nassel
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    Peptides 32:1335-55. 2011
    b>Neuropeptides referred to as neuropeptide F (NPF) and short neuropeptide F (sNPF) have been identified in numerous invertebrate species. Sequence information has expanded tremendously due to recent genome sequencing and EST projects...
  35. ncbi Hypothalamic orexin neurons regulate arousal according to energy balance in mice
    Akihiro Yamanaka
    Institute of Basic Medical Science, University of Tsukuba, 305 8575, Ibaraki, Japan
    Neuron 38:701-13. 2003
    ..Transgenic mice, in which orexin neurons are ablated, fail to respond to fasting with increased wakefulness and activity. These findings indicate that orexin neurons provide a crucial link between energy balance and arousal...
  36. pmc Sleep and synaptic homeostasis: structural evidence in Drosophila
    Daniel Bushey
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Science 332:1576-81. 2011
    ..A richer wake experience resulted in both larger synaptic growth and greater sleep need. Finally, we demonstrate that the gene Fmr1 (fragile X mental retardation 1) plays an important role in sleep-dependent synaptic renormalization...
  37. ncbi Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brain
    Yan Ling Xu
    Department of Pharmacology, University of California Irvine, Irvine, California 92697, USA
    J Comp Neurol 500:84-102. 2007
    ..These data suggest that the NPS system may play a key role in modulating a variety of physiological functions, especially arousal, anxiety, learning and memory, and energy balance...
  38. ncbi PKC-1 regulates secretion of neuropeptides
    Derek Sieburth
    Department of Molecular Biology, Simches 7, Massachusetts General Hospital, 185 Cambridge St, Boston, Massachusetts 02114, USA
    Nat Neurosci 10:49-57. 2007
    The secretion of neurotransmitters and neuropeptides is mediated by distinct organelles-synaptic vesicles (SVs) and dense-core vesicles (DCVs), respectively...
  39. ncbi PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors
    Inge Mertens
    Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Neuron 48:213-9. 2005
    ..These data establish the first synapse within the Drosophila circadian neural circuit and underscore the importance of Class II peptide GPCR signaling in circadian neural systems...
  40. pmc Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
    Rolf Knoth
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    PLoS ONE 5:e8809. 2010
    ....
  41. ncbi Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response
    Raphaelle Winsky-Sommerer
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:11439-48. 2004
    The hypothalamic neuropeptides hypocretins (orexins) play a crucial role in the stability of arousal and alertness...
  42. ncbi Doublecortin expression in the adult rat telencephalon
    J Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Neurosci 14:629-44. 2001
    ..Given these results, we hypothesize that DCX expression in differentiated neurons could be related to its capacity for microtubule reorganization and that this fact could be linked to axonal outgrowth or synaptogenesis...
  43. pmc GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus
    Ravi Jagasia
    Research Group Adult Neural Stem Cells and Neurogenesis, Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Munich Neuherberg, Germany
    J Neurosci 29:7966-77. 2009
    ..These results indicate that CREB signaling is a central pathway in adult hippocampal neurogenesis, regulating the development and survival of new hippocampal neurons downstream of GABA-mediated excitation...
  44. ncbi Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
    Michelle Y Cheng
    Department of Pharmacology, University of California, Irvine, California 92697, USA
    Nature 417:405-10. 2002
    ..The high expression of PKR2 mRNA within the SCN and the positive feedback of PK2 on its own transcription through activation of PKR2 suggest that PK2 may also function locally within the SCN to synchronize output...
  45. pmc Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
    Oum Kaltoum Hassani
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 106:2418-22. 2009
    ....
  46. pmc Afferents to the orexin neurons of the rat brain
    Kyoko Yoshida
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 494:845-61. 2006
    ..These observations suggest that the orexin neurons may integrate a variety of interoceptive and homeostatic signals to increase behavioral arousal in response to hunger, stress, circadian signals, and autonomic challenges...
  47. ncbi Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system
    T L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 415:145-59. 1999
    ..Thus, the hypocretin innervation of the LC may serve to focus cognitive processes to compliment hypocretin-mediated activation of autonomic centers already described...
  48. ncbi Neuropeptides in helminths: occurrence and distribution
    Nikki J Marks
    Parasitology, School of Biological Sciences, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Adv Exp Med Biol 692:49-77. 2010
    ..Although the actual neuropeptides provide limited obvious value as targets for chemotherapeutic-based control strategies, they do highlight the ..
  49. ncbi Drosophila short neuropeptide F regulates food intake and body size
    Kyu Sun Lee
    Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology, 52 Eoun dong, Yusong gu, Daejeon, 395 333, Korea
    J Biol Chem 279:50781-9. 2004
    b>Neuropeptides regulate a wide range of animal behavior including food consumption, circadian rhythms, and anxiety...
  50. ncbi Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish
    David A Prober
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 26:13400-10. 2006
    ....
  51. doi Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
    Markus Heinrichs
    Department of Psychology, Clinical Psychology and Psychobiology, University of Zurich, Zurich, Switzerland
    Prog Brain Res 170:337-50. 2008
    ..In non-human mammals, the neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are key mediators of complex social behaviours, including ..
  52. doi Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?
    Dick R Nassel
    Department of Zoology, Stockholm University, 10691 Stockholm, Sweden
    Invert Neurosci 9:57-75. 2009
    ..Thus, neuropeptides are produced by a huge variety of neuron types in different parts of the nervous system...
  53. ncbi Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress
    Brian A Baldo
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    J Comp Neurol 464:220-37. 2003
    ....
  54. doi Doublecortin-positive cells in the adult primate cerebral cortex and possible role in brain plasticity and development
    Jocelyne Bloch
    Neurosurgery Research Group, CHUV UNIL, CH 1011 Lausanne, Switzerland
    J Comp Neurol 519:775-89. 2011
    ..Moreover, in vitro these DCX-positive cells have the potential to reacquire progenitor characteristics that confirm their potential for brain repair...
  55. ncbi A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila
    S C Renn
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Cell 99:791-802. 1999
    ..These results confirm the assignment of LNv neurons as the principal circadian pacemakers controlling daily locomotion in Drosophila. They also implicate PDF as the principal circadian transmitter...
  56. ncbi Coupled oscillators control morning and evening locomotor behaviour of Drosophila
    Dan Stoleru
    Howard Hughes Medical Institute and National Center for Behavioural Genomics, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 431:862-8. 2004
    ..Although the two oscillators can function autonomously, cell-specific rescue experiments with circadian clock mutants indicate that they are functionally coupled...
  57. pmc Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala
    Kay Jüngling
    Institute of Physiology I Neurophysiology, Westfälische Wilhelms University Münster, Robert Koch Strasse 27a, D 48149 Munster, Germany
    Neuron 59:298-310. 2008
    ..These results identify mechanisms of NPS in the brain, a key role of intercalated neurons in the amygdala for fear extinction, and a potential pharmacological avenue for treating anxiety disorders...
  58. doi Biomarkers of PTSD: neuropeptides and immune signaling
    Dewleen G Baker
    Veterans Affairs Center of Excellence for Stress and Mental Health, VA San Diego, CA, USA
    Neuropharmacology 62:663-73. 2012
    ..Potential research implications and directions are discussed. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  59. pmc Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers
    Stephanie L Borgland
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
    J Neurosci 29:11215-25. 2009
    ....
  60. ncbi Fos expression in orexin neurons varies with behavioral state
    I V Estabrooke
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 21:1656-62. 2001
    ..Conversely, relative inactivity of orexin neurons may allow the expression of sleep...
  61. pmc Neuropeptides regulate swimming depth of Platynereis larvae
    Markus Conzelmann
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 108:E1174-83. 2011
    ..We found several neuropeptides expressed in distinct sensory neurons that innervate locomotor cilia...
  62. ncbi A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans
    Z Altun-Gultekin
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Development 128:1951-69. 2001
    ..Our findings illustrate the complexity of transcriptional regulation in the nervous system and provide an example for the intricate interdependence of transcription factor action...
  63. ncbi Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice
    Takeshi Sakurai
    Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305 8575, Japan
    Neuron 46:297-308. 2005
    ..These neuroanatomical findings provide important insights into the neural pathways that regulate sleep/wakefulness states...
  64. ncbi Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins
    B Xiao
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:707-16. 1998
    ..These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties...
  65. ncbi Transient expression of doublecortin during adult neurogenesis
    Jason P Brown
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    J Comp Neurol 467:1-10. 2003
    ..This assumption is further supported by our observation that the number of DCX-expressing cells in the dentate gyrus was decreased with age according to the reduction of neurogenesis in the aging dentate gyrus previously reported...
  66. ncbi Mice lacking melanin-concentrating hormone are hypophagic and lean
    M Shimada
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Nature 396:670-4. 1998
    Feeding is influenced by hypothalamic neuropeptides that promote (orexigenic peptides) or inhibit feeding...
  67. ncbi Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ
    Denis Burdakov
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 25:2429-33. 2005
    ..We propose that these direct actions of glucose on the arousal- and metabolism-regulating LH neurons play a key role in the translation of normal variations in body energy resources into appropriate changes in arousal and metabolism...
  68. ncbi Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system
    Ying Li
    Department of Neurosurgery, Yale University, New Haven, CT 06520, USA
    Neuron 36:1169-81. 2002
    ..Norepinephrine and serotonin, transmitters of other arousal systems, decreased spike frequency and evoked outward currents, whereas acetylcholine and histamine had little effect...
  69. ncbi The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons
    Xin Fang
    Department of Physiology, University of Bristol, Medical School, Bristol BS8 1TD, United Kingdom
    J Neurosci 22:7425-33. 2002
    ..The data provide direct evidence that Na(v)1.9 is expressed selectively in (but not in all) C- and A-fiber nociceptive-type units and suggest that Na(v)1.9 contributes to membrane properties that are typical of nociceptive neurons...
  70. ncbi Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins
    Yun Zhu
    Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    J Pharmacol Sci 92:259-66. 2003
    ..This suggests that although OX2R couples to multiple G-proteins, activation of neurons by orexins through OX2R is mediated via a PTX-insensitive, PLC dependent pathway...
  71. pmc The orexin system regulates alcohol-seeking in rats
    Andrew J Lawrence
    Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Royal Parade, Parkville, Victoria 3010, Australia
    Br J Pharmacol 148:752-9. 2006
    ....
  72. ncbi The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
    B J Oldfield
    Howard Florey Institute, University of Melbourne, VIC Australia
    Neuroscience 110:515-26. 2002
    ..These data provide part of an anatomical framework which subserves the regulation of energy expenditure...
  73. pmc Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 105:2640-5. 2008
    ..In summary, our studies verify a role for Bv8 in the mobilization and recruitment of myeloid cells and in the induction of tumor angiogenesis in the early stages of neoplastic progression...
  74. pmc Discovery of defense- and neuropeptides in social ants by genome-mining
    Christian W Gruber
    Medical University of Vienna, Center for Physiology and Pharmacology, Vienna, Austria
    PLoS ONE 7:e32559. 2012
    ..With natural product drug discovery in mind, we devised a genome-mining approach to identify defense- and neuropeptides in the genomes of social ants from Atta cephalotes (leaf-cutter ant), Camponotus floridanus (carpenter ant) ..
  75. pmc Peptide neuromodulation in invertebrate model systems
    Paul H Taghert
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
    Neuron 76:82-97. 2012
    b>Neuropeptides modulate neural circuits controlling adaptive animal behaviors and physiological processes, such as feeding/metabolism, reproductive behaviors, circadian rhythms, central pattern generation, and sensorimotor integration...
  76. pmc Genomics, transcriptomics, and peptidomics of neuropeptides and protein hormones in the red flour beetle Tribolium castaneum
    Bin Li
    Department of Entomology, Kansas State University, Manhattan, Kansas 66506 4004, USA
    Genome Res 18:113-22. 2008
    b>Neuropeptides and protein hormones are ancient molecules that mediate cell-to-cell communication...
  77. ncbi Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections
    E E Abrahamson
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Brain Res 916:172-91. 2001
    ..The organization of the mouse SCN, and its connections, are similar to that in other mammalian species...
  78. ncbi Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice
    Françoise Phan Dinh Tuy
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Dev Neurosci 30:171-86. 2008
    ..These results, in addition to characterizing the transcript diversity of an important family of genes, should facilitate further studies of compensation in Dcx-deficient mice...
  79. ncbi Indirect projections from the suprachiasmatic nucleus to major arousal-promoting cell groups in rat: implications for the circadian control of behavioural state
    S Deurveilher
    Department of Anatomy and Neurobiology, Faculty of Medicine, Dalhousie University, 5850 College Street, Halifax, Nova Scotia, B3H 1X5, Canada
    Neuroscience 130:165-83. 2005
    ..In the absence of major direct SCN projections to most of these sleep/wake-regulatory regions, indirect neuronal pathways probably play an important role in the circadian control of sleep-wake cycles and other physiological functions...
  80. pmc Discovery and evolutionary history of gonadotrophin-inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction
    K Tsutsui
    Department of Biology, Waseda University, Tokyo, Japan
    J Neuroendocrinol 22:716-27. 2010
    ..However, within the last decade, two other hypothalamic neuropeptides have been found to play key roles in the control of reproductive functions: gonadotrophin-inhibitory hormone (..
  81. ncbi Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes
    Jon T Willie
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 38:715-30. 2003
    Narcolepsy-cataplexy, a neurological disorder associated with the absence of hypothalamic orexin (hypocretin) neuropeptides, consists of two underlying problems: inability to maintain wakefulness and intrusion of rapid eye movement (REM) ..
  82. pmc Role of CRF and other neuropeptides in stress-induced reinstatement of drug seeking
    Uri Shalev
    Department of Psychology, Center for Studies in Behavioral Neurobiology Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, Canada
    Brain Res 1314:15-28. 2010
    ..For this special issue entitled "The role of neuropeptides in stress and addiction", we review results from studies on the role of corticotropin-releasing factor (CRF) ..
  83. pmc Reverse physiology in drosophila: identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family
    N Birgul
    Institut fur Zellbiochemie und klinische Neurobiologie, Universitat Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    EMBO J 18:5892-900. 1999
    ....
  84. doi Impact of prosocial neuropeptides on human brain function
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, Mannheim, Germany
    Prog Brain Res 170:463-70. 2008
    ....
  85. ncbi Signals that regulate food intake and energy homeostasis
    S C Woods
    Department of Psychiatry, University of Cincinnati Medical Center, Post Office Box 670559, Cincinnati, OH 45267 0559, USA
    Science 280:1378-83. 1998
    ..This review focuses on the molecular signals that modulate food intake while integrating the body's immediate and long-term energy needs...
  86. pmc A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release
    Zhitao Hu
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuron 71:92-102. 2011
    ..Collectively, these results suggest that NLP-12 mediates a mechanosensory feedback loop that couples muscle contraction to changes in presynaptic release, thereby providing a mechanism for proprioceptive control of locomotion...
  87. ncbi Neural control of muscle relaxation in echinoderms
    M R Elphick
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    J Exp Biol 204:875-85. 2001
    Smooth muscle relaxation in vertebrates is regulated by a variety of neuronal signalling molecules, including neuropeptides and nitric oxide (NO)...
  88. doi Pheromone biosynthesis activating neuropeptide (PBAN): regulatory role and mode of action
    Ada Rafaeli
    Agriculture Research Organization, Volcani Center, P O Box 6, Bet Dagan 50250, Israel
    Gen Comp Endocrinol 162:69-78. 2009
    ..In the latter tissue, no activity and/or receptor-binding can be detected in response to PBAN. These results raise many questions concerning the evolutionary role of the PBAN/Pyrokinin receptors belonging to the GPCR family...
  89. ncbi Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions
    Rong Jian Liu
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:9453-64. 2002
    ..The greater potency of hcrts in direct excitation compared with indirect inhibition suggests a negative feedback function for the latter at higher levels of hcrt activity...
  90. ncbi A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins
    Antony A Boucard
    Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard NA4 118, Dallas, Texas 75390, USA
    Neuron 48:229-36. 2005
    ....
  91. ncbi Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain
    Brigitte Grima
    Institut de Neurobiologie Alfred Fessard NGI, CNRS UPR 2216, Centre National de la Recherche Scientifique, av de la Terrasse, 91198 Gif sur Yvette, France
    Nature 431:869-73. 2004
    ..Furthermore, we show that the LN(v)s alone can generate 24 h activity rhythms in constant darkness, indicating that the morning oscillator is sufficient to drive the circadian system...
  92. ncbi Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF
    Seogang Hyun
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Korea
    Neuron 48:267-78. 2005
    ..Therefore, we herein propose that Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons...
  93. pmc Drosophila free-running rhythms require intercellular communication
    Ying Peng
    Department of Biology, Brandeis University, Waltham, Massachusetts, USA
    PLoS Biol 1:E13. 2003
    ..The cooperative function of this network appears to be necessary for maintaining robust molecular oscillations in DD and is the basis of sustained circadian locomotor activity rhythms...
  94. ncbi Visualization of neuropeptide expression, transport, and exocytosis in Drosophila melanogaster
    S Rao
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    J Neurobiol 49:159-72. 2001
    b>Neuropeptides affect an extremely diverse set of physiological processes. Neuropeptides are often coreleased with neurotransmitters but, unlike neurotransmitters, the neuropeptide target cells may be distant from the site(s) of secretion...
  95. pmc Drosophila egg-laying site selection as a system to study simple decision-making processes
    Chung Hui Yang
    Howard Hughes Medical Institute, Department of Physiology, Biochemistry, and Biophysics, University of California at San Francisco, San Francisco, CA 94143 0725, USA
    Science 319:1679-83. 2008
    ..These findings suggest that selection of egg-laying site involves a simple decision-making process and provide an entry point toward a systematic dissection of this process...
  96. ncbi The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity
    Fumimasa Amaya
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:12852-60. 2006
    ..9-/- mice. Na(v)1.9 is, we conclude, an effector of the hypersensitivity produced by multiple inflammatory mediators on nociceptor peripheral terminals and therefore plays a key role in mediating peripheral sensitization...
  97. ncbi Insect peptide hormones: a selective review of their physiology and potential application for pest control
    Gerd Gäde
    Zoology Department, University of Cape Town, Rondebosch, South Africa
    Pest Manag Sci 59:1063-75. 2003
    ..release, receptor binding, structure-activity relationships, mode of action and degradation of, mainly, neuropeptides from insects has increased dramatically during the last 10 years or so...
  98. ncbi Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions
    Erik C Johnson
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:52172-8. 2003
    ..identities of ligands for several recently de-orphaned receptors, including the receptors for the Drosophila neuropeptides proctolin (CG6986), neuropeptide F (CG1147), corazonin (CG10698), dFMRF-amide (CG2114), and allatostatin C (..
  99. ncbi Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    O Jameel Shah
    Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 14:1650-6. 2004
    ..Our results suggest that inappropriate activation of the Rheb/mTOR/S6K pathway imposes a negative feedback program to attenuate IRS-dependent processes such as cell survival...
  100. ncbi VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFNgamma synthesis by T cells
    M Delgado
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102 1811, USA
    J Neuroimmunol 96:167-81. 1999
    ..This study examines the effect of two neuropeptides, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP), on ..
  101. ncbi Neuromedin U and its receptors: structure, function, and physiological roles
    Paul J Brighton
    Department of Cell Physiology and Pharmacology, Maurice Shock Medical Sciences Building, University of Leicester, University Road, Leicester, LE1 9HN United Kingdom
    Pharmacol Rev 56:231-48. 2004
    ....

Research Grants71

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  3. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..in the sensory ganglia of these mice, with an emphasis on genes mediating pain pathways, including sensory neuropeptides and members of the Trp, Mrg and NaV gene families...
  4. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..inflammation in psoriasis is suggested by proliferation of lesional cutaneous nerves, upregulation of neuropeptides, and clearance of psoriasis at the sites of anesthesia...
  5. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..abstract_text> ..
  6. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..will train me in the construction of custom-made microdialysis probes with the pore size suitable for neuropeptides, as well as probes validation and optimal implantation into the PVN and BNST...
  7. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..This grant proposal will study several potential abnormalities of the immune system caused by chronic loss of sleep in the mouse model of human RA and how the sympathetic nervous system contributes to the severe arthritis. ..
  8. Central Action of Brain-Derived Neurotrophic Factor in Male and Female Rats
    Haifei Shi; Fiscal Year: 2010
    ....
  9. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..A focus for many years in this field has been the neuropeptides involved in energy regulation, and the hypothalamic neurons that secrete them...
  10. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..Other PVN neuropeptides, such as vasopressin (AVP) and oxytocin (OT), modulate activity of CRH neurons at the level of the PVN as well ..
  11. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..pain in somatic models, and we have shown that TRPV1 mediates pancreatic inflammatory pain via the release of neuropeptides both in the pancreas and spinal cord, whether the newer ion channels TRPV4 and TRPA1 participate in pancreatic ..
  12. Functional Neuroimaging of Individual Differences in Affect and Motivation
    BRIAN JAMES MICKEY; Fiscal Year: 2013
    ..At the same time, the project will address important, testable questions about the neurobiology of genetic vulnerability to MDD, an identified public health priority. ..
  13. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..g. galanin, NPY, VIP, substance P) phenotype. A large collection of the relevant EGFP-expressing transgenic mouse lines has been generated and is available at the NIH- supported GENSAT resource. ..
  14. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ..mechanisms by which bacteria elicit an inflammatory response at mucosal sites;however, a pathway mediated by neuropeptides has received little attention but may be equally as important in the induction of the inflammatory response by ..
  15. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..In our group, we recently showed that neuropeptides such as substance P, corticotropin-releasing hormone, and neurotensin, that are involved in both the stress ..
  16. Neuropeptide regulation of neurohypophyseal function
    Francis W Flynn; Fiscal Year: 2012
    ..The nuclear translocation of the neurokinin receptor to the nucleus is novel and has implications for a large number of pathologies, such as epilepsy, that are linked to this receptor system in the brain. ..
  17. Hormonal regulation of a Ca2+/AMPK signaling pathway
    Anthony R Means; Fiscal Year: 2013
    ..Because inflammation is such a prevalent cause of or response to numerous human diseases we believe our studies will reveal CaMKK2 to be an important, novel target for therapeutic intervention. ..
  18. ROLE OF FORKHEAD PROTEINS IN INSULIN ACTION
    Domenico Accili; Fiscal Year: 2013
    ..Therefore, it is hoped that by parsing its modes of action and interacting partners, new ways to modulate its function can be found. ..
  19. Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome Risk
    PEI AN SHIH; Fiscal Year: 2013
    ....
  20. Hypothalamic SIRT1 and Energy Balance
    Eduardo A Nillni; Fiscal Year: 2013
    ..2. Exposure to High Fat Diet (HFD) alters hypothalamic Sirt1 expression, signaling, and Sirt1 co- substrate/activator NAD+ levels. 3. The inhibitory effect of Sirt1 on mTOR signaling in the DIO condition is one of the causes of obesity. ..
  21. Neuropeptide modulation of biogenic amine function and aggression in a crustacean
    Maria A Sosa; Fiscal Year: 2013
    ..research are to: (1) Characterize the role played by proctolin, FMRFamide, SIFamide and newly identified prawn neuropeptides in modulating natural aggressive behaviors of the prawn male morphotypes and aggressive behaviors induced by ..
  22. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
    ..This knowledge will provide insights into new drug targets to prevent, treat, and ultimately cure mental illness. ..
  23. Mechanisms of Diabetic Hyperphagia and Insulin Resistance
    Michael W Schwartz; Fiscal Year: 2012
    ..By improving our understanding of how mechanisms driving obesity and diabetes are linked to one another within the brain, our ultimate goal is to find new strategies for their prevention and treatment. ..
  24. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    Dennis G Drescher; Fiscal Year: 2013
    ....
  25. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    ..Serotonin (5-HT) is abundant in gastrointestinal tract and one of the major neuropeptides involved in pathogenesis of IBS...
  26. Molecular control of differential peptide transmitter exocytosis.
    COREY B SMITH; Fiscal Year: 2013
    ..The data obtained will provide a molecular understanding of the key regulators of the acute sympatho-adrenal stress response as well as pathologies resulting from its improper regulation. ..
  27. Neprilysin and Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
    EDWARD CHARLES DEMPSEY; Fiscal Year: 2013
    ..a transmembrane protein with a cell surface peptidase activity that degrades select pro- and anti-inflammatory neuropeptides and may take part in signaling cascades by directly coupling to intracellular proteins via peptidase-..
  28. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ..as a neuroendocrine compartment during liver disease pathogenesis and secrete and respond to hormones and neuropeptides, which contribute to the autocrine and paracrine pathways that modulate liver inflammation and biliary ..
  29. In vivo targeted gene silencing, a novel method
    WILLIAM ANTHONY TRUITT; Fiscal Year: 2012
    ..These Tacr1 interneurons represent a subpopulation of BLA-interneurons that contain the neuropeptides somatostatin (Sst) and cholecystokinin (Cck), and although these cells appear to be pivotal in the regulation ..
  30. Novel Small Molecule Therapeutics to Treat Obesity
    SUSAN MEDGHALCHI; Fiscal Year: 2010
    ..and reduce serum triglyceride levels in DIO mice, (f) increase expression of anorexigenic hypothalamic neuropeptides, and (g) enhance the expression of genes that favor fatty acid oxidation in liver and adipose tissue...
  31. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2013
    ....
  32. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..neurons produces local vasodilation, plasma extravasation, and pain and is due largely to release of the neuropeptides substance P and calcitonin gene-related peptide (CGRP)...
  33. Molecular Physiology of the Epitrachael Endocrine System
    Michael E Adams; Fiscal Year: 2012
    ..Results of these studies also may provide basic new information about vector-borne human diseases involving mosquitoes, flies, ticks, and other arthropods. ..
  34. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2013
    ..Our proposed study will help to understand the roles of CD38 plays in normal and pathological conditions, and potentially lead to new ways to treat human diseases involving CD38. ..
  35. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2009
    ..Aim #3. We will test the hypothesis that NPY down regulates the prohormone convertases 1 and 2 (PC1/2). Aim #4. We will identify the role of the egr-1 transcription factor in regulating PC2 by leptin and NPY ..
  36. Mechanisms for the Effects of Hypothalamic PTP1B on Energy Balance
    KARYN JOANNE CATALANO; Fiscal Year: 2010
    ..in the leptin pathway such as STATS and AMPK, and the ability of leptin to induce expression of important neuropeptides for energy regulation...
  37. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
    ..Second, we propose to develop therapies based on novel therapeutic targets. Furthermore, we develop a model of OP-induced seizures that can be used in civilian ..
  38. Sex Differences in Stress Receptors Underlie Female Vulnerability to Stress
    Debra A Bangasser; Fiscal Year: 2012
    ..This project will not only help us understand why women are more vulnerable to stress-related mental illnesses, but it will identify new pharmaceutical targets which can lead to treatments that are efficacious in both men and women. ..
  39. MOUSE MODELS OF INSULIN RESISTANCE
    Domenico Accili; Fiscal Year: 2013
    ..The driving theme of our work is to define molecular pathways that can be enlisted in the clinic against insulin resistance. ..
  40. Systemic Factors that Maintain a Young Liver Phenotype
    Roy G Smith; Fiscal Year: 2012
    ..Ghrelin levels decline as a function of age. Our research is designed to test whether replacing this hormone with a more stable form will provide health and quality of life benefits during aging. ..
  41. Modulation of insulin and glucagon secretion by GPCR ligands
    TARA ASHLEY SCHWETZ; Fiscal Year: 2011
    ....
  42. Route of Nutrition and Enteric Nervous System Effects on Innate Mucosal Defense
    Kenneth A Kudsk; Fiscal Year: 2013
    ..We showed that providing ENS neuropeptides maintains aspects of both acquired and the innate immunity...
  43. Interaction of Estrogen and AMPK in the Hypothalamus
    Jessica Healy; Fiscal Year: 2012
    ..Estradiol is anorexigenic in rodents and humans. Food intake is regulated by a variety of exigenic neuropeptides (neuropeptide Y, NPY;agouti-related protein, AgRP) and anorexigenic neuropeptides (pro- opiomelanocortin, POMC)..
  44. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..The proposed studies will focus on two major influences that can regulate thalamocortical gating: neuropeptides and inhibitory mechanisms...
  45. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
    ..We will investigate how this increase of inhibitory neuropeptide will enhance the dentate gyrus filtering of incoming activity such as seizures and how this increased filtering can affect seizure-induced hippocampal damage. ..
  46. 18F-beta-Endorphin Imaging: Translational Study of an Opioid Peptide Radiotracer
    BRIAN contact REED; Fiscal Year: 2010
    ..amino-oxy derivative of -endorphin would also have broader impact in neuroimaging as it is applicable to other neuropeptides and peptidic hormones and analogs thereof...
  47. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2013
    PROJECT SUMMARY/ABSTRACT The corticotropin-releasing factor (CRF) family of neuropeptides (CRF and urocortins [Ucn] 1-3) and their receptors (CRFR1, CRFR2) are essential mediators of stress in the central nervous system...
  48. Prenatal stress and accelerated atherosclerosis in ApoE knockout mice
    Subeena Sood; Fiscal Year: 2012
    ..Identifying the genes and pathways through which prenatal stress impacts human disease will provide opportunities for treatment or prevention of these effects in adulthood. ..
  49. BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETES
    Barry E Levin; Fiscal Year: 2013
    ....
  50. Cathepsin L in the Biosynthesis of Enkephalins and beta-Endorphin Opioid Peptides
    Steven J Bark; Fiscal Year: 2012
    ..Enkephalin and beta-endorphin are opioid neuropeptides that have been implicated in adverse neurological disease conditions for mental state, chronic pain, drug and ..
  51. Role of Neuropeptide Y in Obesity-Receptor Specific Analogs
    Ambikaipakan Balasubramaniam; Fiscal Year: 2013
    ..This could enhance recall opportunities and reduce the burden on the Veterans Health Care cost. ..
  52. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..This proposal thus addresses important questions about how leptin can affect reproductive competence at the level of the pituitary. ..
  53. Neurobiological mechanisms of nicotine reinforcement: Role of the nucleus tractus
    LUIS MIGUEL TUESTA; Fiscal Year: 2012
    ..Results from the experiments outlined in this proposal will increase our basic understanding of nicotine addiction, and may provide exciting targets for the development of novel therapeutics for smoking cessation. ..
  54. Mechanisms of Programmed Gestational Hyperphagia
    MICHAEL GLENN ROSS; Fiscal Year: 2012
    ..e., cFOS) and expression of anorexigenic/orexigenic signaling factors and neuropeptides following fed/fasting and leptin/d-fen...
  55. REGULATION OF CELLULAR RESPONSES TO NEUROPEPTIDES
    Nigel W Bunnett; Fiscal Year: 2010
    ..For type specifications, see Specific Instructions onpage 10.) RESEARCH GRANT TABLE OF CONTENTS PAGE NUMBERS Face page 1 Description, ..
  56. Germ cell specifications and differentiation in planarians.
    Phillip A Newmark; Fiscal Year: 2013
    ....
  57. Sex Differences in Stress Receptors Underlie Female Vulnerability to Stress
    Debra A Bangasser; Fiscal Year: 2013
    ..Moreover, because CRF antagonists are being developed to treat these illnesses, considering sex differences in CRF receptors may increase the efficacy of these compounds in women. ..
  58. Orexin Receptor Agonists for the Treatment of Excessive Daytime Sleepiness and Ca
    PAUL STUART HUMPHRIES; Fiscal Year: 2013
    ..The orexins are a pair of neuropeptides expressed by specific populations of neurons in the lateral hypothalamic area...
  59. Control of developmental timing and body size in Drosophila
    MICHAEL BRENDAN O'CONNOR; Fiscal Year: 2013
    ....
  60. DEPOLARIZATION-SECRETION COUPLING IN NERVE TERMINALS
    Jose R Lemos; Fiscal Year: 2012
    ..The molecular details of how calcium and other ionic currents control the release of neuropeptides from nerve terminals in the intact central nervous system (CNS), however, remain undetermined...
  61. Chimpanzee Biomedical Research Program Limited Competition (U42)
    M Babette Fontenot; Fiscal Year: 2013
    ..of the relationship between specific behavioral phenotypes and levels of central monoamine metabolites and neuropeptides. 3)To collaborate and share data freely with the chimpanzee database grantees, investigators whose efforts ..
  62. CRF and Stress Modulation of Phasic Dopamine Release and Behavior
    MATTHEW J WANAT; Fiscal Year: 2013
    ....
  63. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    ..significant, since inhibition of nociceptive primary afferent neurons could alter both peripheral secretion of neuropeptides (reducing neurogenic inflammation), and possibly, membrane depolarization under control conditions...
  64. Neuropeptide Regulation Vasopressin/Oxytocin Secretion
    CELIA SLADEK; Fiscal Year: 2006
    ..Understanding the role of specific neurotransmitters in relaying hemodynamic information to the VP and OT neurons is central to manipulating the system for treatment of pathological conditions. ..
  65. DIOXINS AND HYPOTHALAMIC APPETITE NEUROPEPTIDES
    GEORGE GREELEY; Fiscal Year: 2000
    ..We propose the hypothesis that disruption in the homeostasis of neuropeptides in hypothalamic centers that control ingestive behavior, by developmental exposure to PCAHs, is a mechanism ..
  66. CYTOKINE EFFECTS IN HYPOTHALAMUS/STEROID MODULATION
    Pushpa Kalra; Fiscal Year: 1999
    ..results indicate the existence of a communication link between the cytokine, Interleukin-1 (IL-1) and certain neuropeptides in the hypothalamus suggesting that the neuroendocrine and behavioral effects of cytokines may be mediated by ..
  67. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2007
    ..abstract_text> ..
  68. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..POMC) precursors, respectively, which require proteolytic processing in secretory vesicles to form active neuropeptides. The extent of PE and POMC processing in chromaffin cells and pituitary, respectively, is limited and varied...
  69. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    RHONDA KINEMAN; Fiscal Year: 2006
    ..determine the mechanisms by which alterations in nutrient availability; 1) regulate hypothalamic expression of neuropeptides essential for normal pituitary GH production (GH-releasing hormone [GHRH] and somatostatin [SRIF]), and 2) ..
  70. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 1999
    ..They are the neuropeptides alpha-melanocyte stimulating hormone (alpha- MSH), and vasoactive intestinal peptide (VIP), along with ..
  71. Hypothalamic Regulation of Energy Homeostasis
    Sharon Wardlaw; Fiscal Year: 2004
    DESCRIPTION: (provided by applicant) The long-term objective of this proposal is to understand how neuropeptides interact in the brain to regulate energy homeostasis...