signal transducing adaptor proteins

Summary

Summary: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes

Top Publications

  1. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
  2. ncbi Toll-like receptors
    Kiyoshi Takeda
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    Annu Rev Immunol 21:335-76. 2003
  3. ncbi Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 437:1167-72. 2005
  4. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
  5. ncbi Innate immune recognition of viral infection
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Suita, Osaka 565 0871, Japan
    Nat Immunol 7:131-7. 2006
  6. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
  7. pmc Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
    Asad Umar
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 96:261-8. 2004
  8. ncbi Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements
    Michael T Veeman
    Department of Pharmacology, Center for Developmental Biology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Curr Biol 13:680-5. 2003
  9. ncbi Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    A Bouchon
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 164:4991-5. 2000
  10. ncbi IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency
    Nat Immunol 6:981-8. 2005

Research Grants

  1. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
  2. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003
  3. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  4. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
  5. Diagnosis and prognosis of lung cancer using gene ratios
    GAVIN GORDON; Fiscal Year: 2004
  6. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
  7. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  8. METHYLATION PROFILING AND RISK OF COLORECTAL CANCER
    Hassan Ashktorab; Fiscal Year: 2007
  9. Cytosolic Phospholipase A2 in Cardiac Hypertrophy
    Thomas Force; Fiscal Year: 2005
  10. Research Echocardiography System
    Thomas Force; Fiscal Year: 2004

Detail Information

Publications328 found, 100 shown here

  1. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
    ..The in vivo CpG-DNA-mediated T-helper type-1 response was also abolished in TLR9-/- mice. Thus, vertebrate immune systems appear to have evolved a specific Toll-like receptor that distinguishes bacterial DNA from self-DNA...
  2. ncbi Toll-like receptors
    Kiyoshi Takeda
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565 0871, Japan
    Annu Rev Immunol 21:335-76. 2003
    ..The TLR-induced inflammatory response is dependent on a common signaling pathway that is mediated by the adaptor molecule MyD88. However, there is evidence for additional pathways that mediate TLR ligand-specific biological responses...
  3. ncbi Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 437:1167-72. 2005
    ..Cardif thus functions as an adaptor, linking the cytoplasmic dsRNA receptor RIG-I to the initiation of antiviral programmes...
  4. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
    ..Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor...
  5. ncbi Innate immune recognition of viral infection
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Suita, Osaka 565 0871, Japan
    Nat Immunol 7:131-7. 2006
    ..These two classes of pattern-recognition receptor molecules are expressed in different intracellular compartments and induce type I interferon responses via distinct signaling pathways...
  6. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  7. pmc Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
    Asad Umar
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 96:261-8. 2004
    ....
  8. ncbi Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements
    Michael T Veeman
    Department of Pharmacology, Center for Developmental Biology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Curr Biol 13:680-5. 2003
    ..Our results support the idea that a vertebrate PCP pathway regulates gastrulation movements and suggest that there is overlap between the PCP and Wnt/calcium pathways...
  9. ncbi Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    A Bouchon
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 164:4991-5. 2000
    ..To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses...
  10. ncbi IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency
    Nat Immunol 6:981-8. 2005
    ..Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses...
  11. ncbi A role for LEDGF/p75 in targeting HIV DNA integration
    Angela Ciuffi
    University of Pennsylvania School of Medicine, Department of Microbiology, 3610 Hamilton Walk, Philadelphia, Pennsylvania 19104 6076, USA
    Nat Med 11:1287-9. 2005
    ..LEDGF is thus the first example of a cellular protein controlling the location of HIV integration in human cells...
  12. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
    ..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
  13. ncbi Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28, rue du Dr Roux, 75724Paris Cedex 15, France
    Science 300:1584-7. 2003
    ..Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing...
  14. ncbi Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
    Jérôme Viala
    Groupe d Immunité Innée et Signalisation, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France
    Nat Immunol 5:1166-74. 2004
    ..pylori than were wild-type mice. We propose that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens...
  15. ncbi IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
    ..Thus, all elements of IFN responses, whether the systemic production of IFN in innate immunity or the local action of IFN from plasmacytoid dendritic cells in adaptive immunity, are under the control of IRF-7...
  16. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
    ..These data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8...
  17. ncbi TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    Eicke Latz
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building 308, 364 Plantation Street, Worcester, MA 01605, USA
    Nat Immunol 5:190-8. 2004
    ..Our data indicate a previously unknown mechanism of cellular activation involving the recruitment of TLR9 from the ER to sites of CpG DNA uptake, where signal transduction is initiated...
  18. ncbi The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    F Hayashi
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 410:1099-103. 2001
    ..Our data suggest that TLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens...
  19. ncbi p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    Serhiy Pankiv
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 282:24131-45. 2007
    ..In fact, p62 bodies and these structures are indistinguishable. Taken together, our results clearly suggest that p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy...
  20. ncbi RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    Koichi Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 416:194-9. 2002
    ..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems...
  21. ncbi TAK1 is a ubiquitin-dependent kinase of MKK and IKK
    C Wang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Nature 412:346-51. 2001
    ..We also provide evidence that TRAF6 is conjugated by the K63 polyubiquitin chains. These results indicate that ubiquitination has an important regulatory role in stress response pathways, including those of IKK and JNK...
  22. ncbi Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
    ..These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses...
  23. pmc Daxx, a novel Fas-binding protein that activates JNK and apoptosis
    X Yang
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 89:1067-76. 1997
    ..The Daxx apoptotic pathway is sensitive to both Bcl-2 and dominant-negative JNK pathway components and acts cooperatively with the FADD pathway. Thus, Daxx and FADD define two distinct apoptotic pathways downstream of Fas...
  24. ncbi IRAK-M is a negative regulator of Toll-like receptor signaling
    Koichi Kobayashi
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 110:191-202. 2002
    ..Endotoxin tolerance, a protection mechanism against endotoxin shock, was significantly reduced in IRAK-M(-/-) cells. Thus, IRAK-M regulates TLR signaling and innate immune homeostasis...
  25. pmc Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
    Genes Dev 12:2610-22. 1998
    ..The PCP signal may selectively result in focal Fz activation and asymmetric relocalization of Dsh to the membrane, where Dsh effects cytoskeletal reorganization to orient prehair initiation...
  26. ncbi Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan Science and Technology Corporation, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 420:324-9. 2002
    ..Instead, TIRAP has a crucial role in the MyD88-dependent signalling pathway shared by TLR2 and TLR4...
  27. ncbi The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    D M Underhill
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 401:811-5. 1999
    ....
  28. ncbi APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
    Xuming Mao
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Nat Cell Biol 8:516-23. 2006
    ..These results demonstrate a key function for APPL1 in adiponectin signalling and provide a molecular mechanism for the insulin sensitizing function of adiponectin...
  29. ncbi Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
    T Kawai
    Department of Host Defense, Research Institute for Microbial Diseases, Japan Science and Technology Corporation, Osaka University, Osaka, Japan
    J Immunol 167:5887-94. 2001
    ....
  30. ncbi The p66shc adaptor protein controls oxidative stress response and life span in mammals
    E Migliaccio
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Nature 402:309-13. 1999
    ..We propose that p66shc is part of a signal transduction pathway that regulates stress apoptotic responses and life span in mammals...
  31. ncbi Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
    Takako Koga
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 428:758-63. 2004
    ..These results reveal that RANKL and M-CSF are not sufficient to activate the signals required for osteoclastogenesis...
  32. ncbi TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
    Atsuhiro Kanayama
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 15:535-48. 2004
    ..These results indicate that polyubiquitin binding domains represent a new class of signaling domains that regulate protein kinase activity through a nonproteolytic mechanism...
  33. pmc Molecular requirements for actin-based lamella formation in Drosophila S2 cells
    Stephen L Rogers
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
    J Cell Biol 162:1079-88. 2003
    ..Our results have identified an essential set of proteins involved in actin dynamics during lamella formation in Drosophila S2 cells...
  34. pmc TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
    Jae Hyuck Shim
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 19:2668-81. 2005
    ..Therefore, our studies suggests that TAK1 acts as an upstream activating kinase for IKKbeta and JNK, but not IKKalpha, revealing an unexpectedly specific role of TAK1 in inflammatory signaling pathways...
  35. ncbi Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
    S M Baker
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201 3098, USA
    Nat Genet 13:336-42. 1996
    ..We also show that Mlh1 appears to localize to sites of crossing over on meiotic chromosomes. Together these findings suggest that Mlh1 is involved in DNA mismatch repair and meiotic crossing over...
  36. ncbi The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
    Lijun Sun
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 14:289-301. 2004
    ..These results reveal an oligomerization --> ubiquitination --> phosphorylation cascade that culminates in NF-kappaB activation in T lymphocytes...
  37. pmc Recognition of single-stranded RNA viruses by Toll-like receptor 7
    Jennifer M Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:5598-603. 2004
    ..These results demonstrate microbial ligand recognition by TLR7 and provide insights into the pathways used by the innate immune cells in the recognition of viral pathogens...
  38. ncbi RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
    Esther M Lafuente
    Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 7:585-95. 2004
    ..RIAM knockdown displaced Rap1-GTP from the plasma membrane and abrogated Rap1-induced adhesion. Thus, RIAM links Rap1 to integrin activation and plays a role in regulating actin dynamics...
  39. pmc Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection
    Ari B Molofsky
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 203:1093-104. 2006
    ..Accordingly, macrophages respond to cytosolic flagellin by a mechanism that requires Naip5 and caspase 1 to restrict bacterial replication and release proinflammatory cytokines that control L. pneumophila infection...
  40. ncbi TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 84:299-308. 1996
    ..Thus, these two TNFR1-TRADD signaling cascades appear to bifurcate at TRADD...
  41. ncbi Toll-like receptor signaling
    Shizuo Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and ERATO of Japan Science and Technology Corporation, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Biol Chem 278:38105-8. 2003
  42. ncbi Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4
    Wei Chen
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    Science 301:1391-4. 2003
    ..These findings provide a previously unrecognized mechanism for receptor recruitment of beta-arrestin and demonstrate that Dvl plays an important role in the endocytosis of frizzled, as well as in promoting signaling...
  43. ncbi Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
    Y Ogura
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Biol Chem 276:4812-8. 2001
    ..The identification of Nod2 defines a subfamily of Apaf-1-like proteins that function through RICK to activate a NF-kappaB signaling pathway...
  44. ncbi Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    Shino Nemoto
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10 6N 240, 10 Center Drive, Bethesda, MD 20892 1622, USA
    Science 295:2450-2. 2002
    ..These results demonstrate an important functional relation between three distinct elements linked to aging: forkhead proteins, p66shc, and intracellular oxidants...
  45. ncbi Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 23:569-82. 1999
    ..Shank may function as a scaffold protein in the PSD, potentially cross-linking NMDA receptor/PSD-95 complexes and coupling them to regulators of the actin cytoskeleton...
  46. ncbi Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies
    E Kuusisto
    1Department of Neuroscience and Neurology, Section of Neuropathology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Neuroreport 12:2085-90. 2001
    ....
  47. ncbi An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid
    Mathias Chamaillard
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Immunol 4:702-7. 2003
    ..Thus, NOD1 mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan...
  48. ncbi Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling
    David R P Tree
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, CA 94305, USA
    Cell 109:371-81. 2002
    ..This activity is linked to Frizzled activity on the adjacent cell surface. Prickle therefore functions in a feedback loop that amplifies differences between Frizzled levels on adjacent cell surfaces...
  49. ncbi A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
    Jianping Jin
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 23:709-21. 2006
    ..These studies uncover diverse substrate receptors for Cul4 and identify Cdt2 as a conserved component of the Cul4-Ddb1 E3 that is essential to destroy Cdt1 and ensure proper cell cycle regulation of DNA replication...
  50. ncbi VISA is an adapter protein required for virus-triggered IFN-beta signaling
    Liang Guo Xu
    Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Mol Cell 19:727-40. 2005
    ..These findings suggest that VISA is critically involved in both virus-triggered TLR3-independent and TLR3-mediated antiviral IFN signaling...
  51. pmc Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression
    Ryan T Saffert
    Institute for Molecular Virology, and McArdle Laboratory for Cancer Research, University of Wisconsin Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    J Virol 80:3863-71. 2006
    ..Furthermore, it provides insight into how a PML-NB protein institutes an intrinsic immune defense against a DNA virus and how HCMV pp71 inactivates this defense...
  52. pmc p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases
    Kurt Zatloukal
    Department of Pathology, Karl Franzens University, Graz, Austria
    Am J Pathol 160:255-63. 2002
    ..The presence of p62 along with other stress proteins and ubiquitin in cytoplasmic inclusions indicates deposition as aggregates as a third line of defense against misfolded proteins in addition to refolding and degradation...
  53. ncbi Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth
    Wange Lu
    California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA
    Cell 119:97-108. 2004
    ..Thus, Ryk appears to play a crucial role in Wnt-mediated signaling...
  54. ncbi TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Nat Immunol 4:1144-50. 2003
    ..TLR4- but not TLR3-mediated MyD88-independent interferon-beta production and activation of signaling cascades were abolished in TRAM-deficient cells. Thus, TRAM provides specificity for the MyD88-independent component of TLR4 signaling...
  55. ncbi IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    M Muzio
    University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA
    Science 278:1612-5. 1997
    ..Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation...
  56. ncbi The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
    Tiffany Horng
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 420:329-33. 2002
    ..Thus, TIRAP is differentially involved in signalling by members of the TLR family and may account for specificity in the downstream signalling of individual TLRs...
  57. ncbi A unified view of the DNA-damage checkpoint
    Justine Melo
    Department of Biochemistry and Biophysics, Mount Zion Cancer Research Center, University of California, San Francisco, CA 94115, USA
    Curr Opin Cell Biol 14:237-45. 2002
    ..This review compares the role of these four classes of checkpoint proteins in humans and model organisms...
  58. ncbi Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc
    Paolo Pinton
    Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation ICSI, University of Ferrara, Ferrera, Italy
    Science 315:659-63. 2007
    ..These data identify a signaling route that activates an apoptotic inducer shortening the life span and could be a potential target of pharmacological approaches to inhibit aging...
  59. ncbi Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts
    J Paloneva
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Nat Genet 25:357-61. 2000
    ..No abnormalities in NK cell function were detected in PLOSL patients homozygous for a null allele of TYROBP...
  60. ncbi A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
    H Kouhara
    Department of Pharmacology, New York University Medical Center, New York 10016, USA
    Cell 89:693-702. 1997
    ..Finally, we demonstrate that FRS2 is closely related and probably indentical to SNT, the long-sought target of FGF and NGF receptors...
  61. pmc Distribution of crossing over on mouse synaptonemal complexes using immunofluorescent localization of MLH1 protein
    L K Anderson
    Department of Biology, Colorado State University, Fort Collins, Colorado 80523, USA
    Genetics 151:1569-79. 1999
    ..The extended length of pachytene SCs, as compared to more condensed diplotene-metaphase I bivalents, makes mapping crossover events and interference distances using MLH1 foci more accurate than using chiasmata...
  62. ncbi Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions
    Xin Zeng
    The F M Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Development 135:367-75. 2008
    ..We discuss the dual roles of the axin-Gsk3 complex and signal amplification by Lrp6-axin interaction during Wnt/beta-catenin signaling...
  63. ncbi Mathematical modeling of planar cell polarity to understand domineering nonautonomy
    Keith Amonlirdviman
    Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
    Science 307:423-6. 2005
    ..The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy...
  64. ncbi Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
    David Teis
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Dev Cell 3:803-14. 2002
    ..Reduction of MP1 or p14 protein levels by siRNAi results in defective signal transduction. Therefore, our results suggest that the endosomal localization of the p14/MP1-MAPK scaffold complex is crucial for signal transduction...
  65. ncbi Casein kinase I transduces Wnt signals
    J M Peters
    Center for Developmental Biology, Department of Molecular Biology, UT Southwestern Medical Center, Dallas, Texas 75235 9133, USA
    Nature 401:345-50. 1999
    ..In addition, CKI bound to and increased the phosphorylation of dishevelled, a known component of the Wnt pathway. These data indicate that CKI may be a conserved component of the Wnt pathway...
  66. ncbi Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO
    Honglin Zhou
    Department of Molecular Oncology, Genentech Inc 1 DNA Way, South San Francisco, California 94080, USA
    Nature 427:167-71. 2004
    ..Thus, the adaptor protein Bcl10 promotes activation of NF-kappaB transcription factors through paracaspase- and UBC13-dependent ubiquitination of NEMO...
  67. ncbi The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
    E J Lowenstein
    Department of Pharmacology, New York University Medical Center, New York 10016
    Cell 70:431-42. 1992
    ..These results suggest that GRB2/sem-5 plays a crucial role in a highly conserved mechanism for growth factor control of ras signaling...
  68. pmc Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha
    Peter C F Cheung
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 22:5793-805. 2003
    ....
  69. ncbi NALPs: a novel protein family involved in inflammation
    Jurg Tschopp
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Rev Mol Cell Biol 4:95-104. 2003
    ....
  70. ncbi Inhibition of death receptor signals by cellular FLIP
    M Irmler
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    Nature 388:190-5. 1997
    ..High levels of FLIP(L) protein are also detectable in melanoma cell lines and malignant melanoma tumours. Thus FLIP may be implicated in tissue homeostasis as an important regulator of apoptosis...
  71. ncbi Toll-like receptor signalling
    Shizuo Akira
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, and ERATO, Japan Science and Technology Agency, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Rev Immunol 4:499-511. 2004
  72. pmc The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
    Maria Paola Paronetto
    Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, 00133 Rome, Italy
    J Cell Biol 176:929-39. 2007
    ..Our results indicate that Sam68 plays a role in the regulation of Bcl-x alternative splicing and that tyrosine phosphorylation of Sam68 by Src-like kinases can switch its role from proapoptotic to antiapoptotic in live cells...
  73. ncbi TIRAP: an adapter molecule in the Toll signaling pathway
    T Horng
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:835-41. 2001
    ..We have also shown that the double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways...
  74. ncbi Cutting edge: TREM-2 attenuates macrophage activation
    Isaiah R Turnbull
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:3520-4. 2006
    ..Taken together, these data show that TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation...
  75. ncbi Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:243-9. 2005
    ..Thus, our study identifies IRF-5 as a new, principal downstream regulator of the TLR-MyD88 signalling pathway and a potential target of therapeutic intervention to control harmful immune responses...
  76. pmc Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection
    Yueh Ming Loo
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 103:6001-6. 2006
    ..HCV protease inhibitors effectively prevent IPS-1 proteolysis, suggesting they may be capable of restoring this innate host response in clinical practice...
  77. ncbi The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways
    Tiejun Zhao
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Canada
    Nat Immunol 8:592-600. 2007
    ..IRF3 phosphorylation and interferon production were restored by ectopic expression of NEMO. Thus, NEMO, like MAVS, acts as an adaptor protein that allows RIG-I to activate both the NF-kappaB and IRF signaling pathways...
  78. ncbi Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    Hiroaki Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 3:196-200. 2002
    ..Imidazoquinoline-induced signaling events were also abolished in both MyD88- and TLR7-deficient mice...
  79. pmc Nuclear receptor corepressor RIP140 regulates fat accumulation
    Goran Leonardsson
    Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 ONN, United Kingdom
    Proc Natl Acad Sci U S A 101:8437-42. 2004
    ....
  80. ncbi Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    Parviz Ahmad-Nejad
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Munich, Germany
    Eur J Immunol 32:1958-68. 2002
    ..These data stress the need to characterize individual TLR at the very beginning of signal initiation in order to understand their diverse biological functions...
  81. pmc LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
    Ming Chieh Shun
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 21:1767-78. 2007
    ..Akin to yeast retrotransposons, disrupting the lentiviral targeting mechanism significantly perturbs overall integration...
  82. pmc The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase
    Attila Mocsai
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:6158-63. 2004
    ..These results provide new insight into the biology of osteoclasts and suggest novel therapeutic targets in diseases of bony remodeling...
  83. ncbi The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway
    Roby P Bhattacharyya
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, San Francisco, CA 94143 2240, USA
    Science 311:822-6. 2006
    ..Thus, scaffolds not only direct basic pathway connectivity but can precisely tune quantitative pathway input-output properties...
  84. pmc Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
    K J Verhey
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 152:959-70. 2001
    ....
  85. pmc Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification
    Jan P Schouten
    MRC Holland, Hudsonstraat 68, 1057SN Amsterdam, The Netherlands
    Nucleic Acids Res 30:e57. 2002
    ..Probe target sequences are small (50-70 nt). The prerequisite of a ligation reaction provides the opportunity to discriminate single nucleotide differences...
  86. ncbi Meiotic pachytene arrest in MLH1-deficient mice
    W Edelmann
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USA
    Cell 85:1125-34. 1996
    ..The phenotypes of the mlh1 mutant mice are distinct from those deficient in msh2 and pms2. The different phenotypes of the three types of mutant mice suggest that these three genes may have independent functions in mammalian meiosis...
  87. ncbi Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
    Valentino Parravicini
    Molecular Inflammation Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Nat Immunol 3:741-8. 2002
    ..Fyn-deficiency impaired degranulation, whereas Lyn-mediated signaling and calcium was normal. Thus, Fc epsilon RI-dependent mast cell degranulation involves cross-talk between Fyn and Lyn kinases...
  88. pmc Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    Jennifer Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 198:513-20. 2003
    ..Therefore, these results demonstrate a novel mechanism whereby the genomic DNA of a virus can engage TLR9 and result in the secretion of IFN-alpha by pDCs...
  89. pmc NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase
    J L Pomerantz
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 18:6694-704. 1999
    ..The TBK1-TANK-TRAF2 signaling complex functions upstream of NIK and the IKK complex and represents an alternative to the receptor signaling complex for TRAF-mediated activation of NF-kappaB...
  90. ncbi Critical role for Gab2 in transformation by BCR/ABL
    Martin Sattler
    Dana Farber Cancer Institute, Department of Adult Oncology, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cancer Cell 1:479-92. 2002
    ..Our results identify Gab2 and its associated proteins as key determinants of the lineage and severity of BCR/ABL transformation...
  91. ncbi Cbl-b regulates the CD28 dependence of T-cell activation
    Y J Chiang
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Nature 403:216-20. 2000
    ....
  92. ncbi Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
    K Bachmaier
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 403:211-6. 2000
    ..Cbl-b is thus a key regulator of activation thresholds in mature lymphocytes and immunological tolerance and autoimmunity...
  93. ncbi Regulation of dendritic spine morphology and synaptic function by Shank and Homer
    C Sala
    Howard Hughes Medical Institute and, Department of Neurobiology, Massachusetts General Hospital and, Harvard Medical School, 02114, Boston, MA, USA
    Neuron 31:115-30. 2001
    ..These data suggest a central role for the Shank scaffold in the structural and functional organization of the dendritic spine and synaptic junction...
  94. pmc Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase
    J C Mallory
    Department of Biology and Curriculum in Genetics and Molecular Biology, CB 3280, Coker Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Proc Natl Acad Sci U S A 97:13749-54. 2000
    ..Tel1p phosphorylates serine in an SQ motif in PHAS-I. Mutations in the kinase domains of Tel1p and Mec1p result in loss of in vitro kinase activity and the in vivo phenotypes associated with the null tel1 and mec1 mutations...
  95. ncbi Unresponsiveness of MyD88-deficient mice to endotoxin
    T Kawai
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 11:115-22. 1999
    ....
  96. ncbi Livin, a novel inhibitor of apoptosis protein family member
    G M Kasof
    AstraZeneca Pharmaceuticals, Enabling Sciences and Technology, Wilmington, Delaware 19803, USA
    J Biol Chem 276:3238-46. 2001
    ..This was associated with an increase in DNA fragmentation and in DEVD-like caspase activity. Thus, disruption of Livin may provide a strategy to induce apoptosis in certain cancer cells...
  97. ncbi Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
    N Inohara
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:14560-7. 1999
    ..Thus, Nod1 is a leucine-rich repeat-containing Apaf-1-like molecule that can regulate both apoptosis and NF-kappaB activation pathways...
  98. pmc Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
    Juha Paloneva
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 71:656-62. 2002
    ....
  99. ncbi Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2
    Stefanie Benesch
    Department of Cell Biology, Gesellschaft fur Biotechnologische Forschung GBF, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    J Biol Chem 277:37771-6. 2002
    ....
  100. pmc Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling
    Keiji Itoh
    Department of Microbiology and Molecular Genetics, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Biol 4:3. 2005
    ..Although Dsh has been detected in a number of cellular compartments, the importance of its subcellular distribution for signaling remains to be determined...
  101. ncbi NOD1 variation, immunoglobulin E and asthma
    Pirro Hysi
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 14:935-41. 2005
    ..The results indicate that intracellular recognition of specific bacterial products affects the presence of childhood asthma...

Research Grants68

  1. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
    ..abstract_text> ..
  2. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003
    ..These studies will help to establish how bacteria can increase apoptosis possibly through generation of ROS and in specific circumstances this may alter one's risk of developing cancer. ..
  3. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  4. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  5. Diagnosis and prognosis of lung cancer using gene ratios
    GAVIN GORDON; Fiscal Year: 2004
    ..Specific Aim 4. To develop software for the expression ratio test and to design a form summarizing the results of the diagnostic test kit to clinicians and health care personnel. ..
  6. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  7. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  8. METHYLATION PROFILING AND RISK OF COLORECTAL CANCER
    Hassan Ashktorab; Fiscal Year: 2007
    ..These studies will help in the detection and _rofiling of genetic changes in the pathway of CRC in AA. ..
  9. Cytosolic Phospholipase A2 in Cardiac Hypertrophy
    Thomas Force; Fiscal Year: 2005
    ..abstract_text> ..
  10. Research Echocardiography System
    Thomas Force; Fiscal Year: 2004
    ....
  11. Ocular Regulation of Autoimmunity
    ROBERT CONE; Fiscal Year: 2009
    ..The results of this study could aid our understanding of the systemic basis for the ocular regulation of autoimmunity and develop procedures for the modulation of active autoimmune disease. ..
  12. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  13. Plasmacytoid Dendritic Cells in Anti-Tumor Response
    Marco Colonna; Fiscal Year: 2008
    ..These findings also substantiate the physiological relevance of the proposed studies to clinical human cancer situations. ..
  14. EM & TIRF analysis of Arp2/3 complex and actin assembly
    BRUCE GOODE; Fiscal Year: 2008
    ..The PI will be directly involved in the integration of TIRF microscopy and single particle imaging into his research program. ..
  15. MECHANISMS OF HIV-1 ENTRY AND PATHOGENESIS IN ASTROCYTES
    Johnny He; Fiscal Year: 2008
    ..They should also aid in the development of strategies for treating neurologic symptoms of AIDS patients. ..
  16. 2008 Biomolecular Interactions and Methods Gordon Research Conference
    Michelle Arkin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  17. CONFOCAL MICROSCOPY SYSTEM
    Sergei Rudchenko; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. Inhibitory Signaling via FcgRIIB Receptor on B Cells
    Kodi Ravichandran; Fiscal Year: 2008
    ....
  19. MAP KINASE CASCADE SIGNAL TRANSMISSION AND SPECIFICITY
    Lee Bardwell; Fiscal Year: 2008
    ....
  20. Apoptotic Cell Recognition & Clearance 2007 Gordon Research Conference
    Kodi Ravichandran; Fiscal Year: 2007
    ..The meeting is purposely held in alternative years with[unreadable] the Apoptosis meeting to encourage participation by all of those with an interest in cell death. ..
  21. RNA Localization 2006
    Joel Richter; Fiscal Year: 2007
    ..The cross-disciplinary nature of this meeting will be attractive to molecular, cellular, developmental, and neurobiological scientists. [unreadable] [unreadable] [unreadable] [unreadable]..
  22. Connexin acetylation: Impact on gap junction function and HDAC inhibitor respons
    JEANNETTE CHLOE BULINSKI; Fiscal Year: 2010
    ..In a broader view, we will also demonstrate novel roles by which protein acetylation regulates cellular functions not directly involved with gene expression. ..
  23. The Functional of TREM-1 in Sepsis
    Marco Colonna; Fiscal Year: 2010
    ..We also have detected a binding partner of TREM-1 (the TREM-1 ligand) and we propose to identify this molecule as it may serve as a novel target for the treatment of septic patients, ..
  24. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  25. Autophagy in Tuberculosis
    VOJO P DERETIC; Fiscal Year: 2011
    ..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
  26. A Multi-Center Study To Map Genes for Fuchs' Dystrophy
    Sudha Iyengar; Fiscal Year: 2009
    ..We anticipate that this study will lead to novel insights into the etiology of FECD and the biology of the corneal endothelium. ..
  27. SIGIRR A Negative Regulator of Toll-IL-IR Signaling
    Xiaoxia Li; Fiscal Year: 2009
    ..Specifically, the proposed studies should result in significant advances in the field of innate mucosal immunity and should also help us to determine the potential of SIGIRR as a target for developing anti-inflammatory drugs. ..
  28. Identifying new genes for branchio-oto-renal syndrome
    Friedhelm Hildebrandt; Fiscal Year: 2009
    ..Identification of new genes causing branchio-oto-renal syndrome will offer new insights into the pathomechanisms of hearing defects, urinary tract malformations as well as kidney and ear development. ..
  29. Drug Abuse and NeuroAIDS in China
    Johnny He; Fiscal Year: 2008
    ..The social and economic impact can not be overemphasized. The current study seeks to have a better understanding of the prevalence and nature of these diseases in the selected population. [unreadable] [unreadable] [unreadable]..
  30. Function of NPHP6 a novel gene for Senior-Loken syndrome
    Friedhelm Hildebrandt; Fiscal Year: 2009
    ..Identification of NPHP6 as a new cause of NPHP and SLS opens new inroads into the understanding of disease mechanisms of renal cystic disease and retinitis pigmentosa. ..
  31. Molecular Mechanisms of IL-1R-TLR-Mediated Signaling
    Xiaoxia Li; Fiscal Year: 2008
    ..The long-term objective is to develop more effective anti-inflammatory and anti-atherogenic small molecule drugs. [unreadable] [unreadable] [unreadable]..
  32. Identification and Functional Assessment of Autism Susceptibility Genes
    Linda Brzustowicz; Fiscal Year: 2009
    ..These accomplishments will lead to important translational research so that better diagnoses, treatments and preventions can be developed for ASD. ..
  33. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2008
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  34. DAUs as IGF-1 Receptor Inhibitors in Breast Cancer
    Jack F Youngren; Fiscal Year: 2010
    ..other kinases, and characterize the biological effects of altering the specificity of DAUs for the IGF-1 R. Together these studies will result in the production of well-characterized DAU-based compounds for anti-cancer drug development. ..
  35. GONADAL AND ENDOMETRIAL FUNCTION IN HUMAN REPRODUCTION
    Renee Reijo Pera; Fiscal Year: 2007
    ..Advances in the Center are anticipated to lead to new diagnostic and therapeutic modalities for reproductive disorders. ..
  36. Regulation of NF-kappaB2 by TSA: Role of Acetylation
    Jing Hu; Fiscal Year: 2007
    ..In addition, we will determine whether p52 acetylation affects the binding of transcription factors Sp-1, AP-1, CREB to cyclin D1 promoter using EMSA and chromatin immunoprecipitation (ChIP). ..
  37. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  38. The identification and characterization of the mammalian mutation mei4
    Jeremy Ward; Fiscal Year: 2006
    ..The characterization of mei4 will not only contribute to our understanding of the basic molecular biology of meiosis but also increase our knowledge of important human health issues. [unreadable] [unreadable] [unreadable]..
  39. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  40. Urinary Podocyte Excretion Using FACS Methodology
    Kevin Lemley; Fiscal Year: 2003
    ..e. is podocyturia an earlier biomarker of incipient nephropathy? and 2) do the responses of albuminuria and podocyturia to treatment with angiotensin-converting enzyme inhibitors differ? ..
  41. Coordinating Adhesion Receptors in Axon Growth
    Jack Lilien; Fiscal Year: 2006
    ..abstract_text> ..
  42. HEPATITIS C VIRUS NS5A PROTEIN AND PATHOGENESIS
    Ratna Ray; Fiscal Year: 2003
    ..Results from this study will lead to a better understanding of the virus mediated pathogenesis. The long term goal of this study is to design effective strategies for the intervention of HCV mediated disease in humans. ..
  43. FUNCTIONAL ROLE OF MBP 1
    Ratna Ray; Fiscal Year: 2006
    ..To investigate the mechanism by which it induces apoptosis To test the biological effect of MBP-1 disruption in KO mice To determine whether adenovirus-mediated MBP-1 gene transfer can regress tumor growth in vivo. ..
  44. PO-Mediated Signaling and Myelination
    Jack Lilien; Fiscal Year: 2006
    ..abstract_text> ..
  45. Tracking Mucosal T cells to Commensal Microbes in Vivo
    Massimo Costalonga; Fiscal Year: 2006
    ..The data will be important to human health, establishing a framework to study in vivo mucosal infectious agents and oral vaccines. ..
  46. Feasibility of Rehabilitation Robots and fMRI in Stroke
    A Tzika; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  47. TRIGGERING OF ABERRANT CPG ISLAND METHYLATION
    Russ Pieper; Fiscal Year: 2002
    ..These studies represent a first step in understanding the gene silencing process and will ultimately contribute to the development of therapies addressed at controlling gene expression. ..
  48. ARL2: Regulator of Cytoskeleton and Mitochondria
    Richard Kahn; Fiscal Year: 2007
    ..And finally, relating these functions and mechanisms to those of the Arfs should also reveal important similarities and differences within the Arf family. [unreadable] [unreadable]..
  49. DIP13alpha and DIP13beta Phosphoinositide Binding
    HEIDI CHIAL; Fiscal Year: 2007
    ..The third aim is to determine whether phosphoinositide binding contributes to the biological functions of DIP13alpha and DIP13beta. ..
  50. Profiling Tumor Cells by SH2 Domain Binding Pattern
    BRUCE MAYER; Fiscal Year: 2002
    ..Variants of the existing profiling method will also be pursued, with the aim of developing a high-throughput method to quantitate binding sites for tens to hundreds of different SH2 domains in a single binding reaction. ..
  51. Examination of the role of LPIN2 variations in skin and bone inflammation
    Hatem El Shanti; Fiscal Year: 2007
    ..Understanding the mechanisms behind psoriasis and CRMO is very important for the development of appropriate therapy. [unreadable] [unreadable] [unreadable]..
  52. Effect of HIV Tat on endothelial cell function
    Lance Terada; Fiscal Year: 2007
    ..The broad objectives of this grant are to further define the nature and significance of Tat dependent oxidant signaling through Hic-5 and EG-1 in endothelial cells. ..
  53. Functional characterization of the gene NPHP4
    Friedhelm Hildebrandt; Fiscal Year: 2007
    ..abstract_text> ..
  54. Alcohol-Induced Regulation of Hepatic Protein Synthesis
    THOMAS VARY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  56. Toll-Like Receptor-Complex in Intestinal Epith. Cells
    Maria Abreu; Fiscal Year: 2007
    ..The results of our studies have important implications for understanding host-microbial interactions and the inter-relationship between the innate and adaptive immune systems in the gut. ..
  57. Regulation of Mu Opioid Receptor Signal Transduction
    LEONARD MURRIN; Fiscal Year: 2004
    ..Further understanding of the regulation of MOR function is relevant not only to development but to clinical situations involving drugs interacting with MOR, such as pain, diarrhea and drug dependence. ..
  58. Role of Par Genes in the Early Mouse Embryo
    VERNADETH ALARCON; Fiscal Year: 2006
    ..An understanding of cell polarization in the mouse embryo should have significant benefit for human health research related to reproductive problems. ..
  59. Paget's Disease of Bone/Dysplasia:Advances/Challenges
    G Roodman; Fiscal Year: 2006
    ..to become aware of the effectiveness of the various drugs that can be used to treat the two disorders; 5.) to understand the role of surgery in managing the two disorders. ..
  60. Program Project Grant-Pathobiology of Paget's Disease
    G Roodman; Fiscal Year: 2007
    ..The knowledge gained from this P01 grant will offer important insights for normal bone cell biology especially for understanding the paracrine regulation of osteoblasts by OCLs. ..
  61. OSTEOCLASTS FROM TRANSGENIC MICE
    G Roodman; Fiscal Year: 2009
    ..Our long-term goal will be to characterize the role of ADAM8/a9b1 in the bone destruction which accompanies collagen induced arthritis, which will be started in grant year 5. ..
  62. DEVELOPMENTAL ASPECTS OF OSTEOCLAST FORMATION IN VITRO
    G Roodman; Fiscal Year: 2005
    ....
  63. PATHOBIOLOGY OF THE OSTEOCLAST IN PAGETS DISEASE
    G Roodman; Fiscal Year: 2002
    ..abstract_text> ..
  64. MECHANISM OF INTERFERON ACTION
    CHARLES SAMUEL; Fiscal Year: 2009
    ..Furthermore, elucidation of the actions of IFN at the molecular level is of importance in view of potential applications of interferon in the clinic. ..
  65. HCV NS5A protein and pathogenesis
    Ratna Ray; Fiscal Year: 2005
    ..This study may also lead to discovery of new therapeutic modalities against persistent HCV infection that affects over 170 million people worldwide. ..
  66. Function of VirK and MsbB2 in Shigella pathogenesis
    MARCIA GOLDBERG; Fiscal Year: 2006
    ..These exploratory studies are highly likely to result in specific testable hypotheses that are relevant to disease. [unreadable] [unreadable] [unreadable]..
  67. Macrophage defense againt M. tuberculosis
    Jennifer Wang; Fiscal Year: 2008
    ..abstract_text> ..
  68. A high- multiplexed phosphotyrosine profiling assay
    BRUCE MAYER; Fiscal Year: 2007
    ..They will also establish the feasibility of the OTM approach as a more general proteomic tool for the rapid and sensitive profiling of clinical samples. ..