Genomes and Genes
rac gtp binding proteins
Summary: A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskeletal filaments. This enzyme was formerly listed as EC 18.104.22.168.
Publications257 found, 100 shown here
- The small GTP-binding protein rac regulates growth factor-induced membrane rufflingA J Ridley
Institute for Cancer Research, Chester Beatty Laboratories, London, England
Cell 70:401-10. 1992..We propose that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin...
- Mammalian Rho GTPases: new insights into their functions from in vivo studiesSarah J Heasman
Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London, UK
Nat Rev Mol Cell Biol 9:690-701. 2008..The recent availability of knockout mice for several members of the Rho family reveals new information about their roles in signalling to the cytoskeleton and in development...
- A brain serine/threonine protein kinase activated by Cdc42 and Rac1E Manser
Institute of Molecular and Cell Biology, National University of Singapore, Kent Ridge
Nature 367:40-6. 1994..This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways...
- Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxisSupriya Srinivasan
Department of Cellular and Molecular Pharmacology and the Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Cell Biol 160:375-85. 2003..We conclude that Rac plays a dominant role in the PI(3,4,5)P3-dependent positive feedback loop required for forming a leading edge, whereas location and stability of the leading edge are regulated by Cdc42...
- Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusionL Luo
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143
Genes Dev 8:1787-802. 1994..Expressions of analogous mutant Dcdc42 proteins cause qualitatively distinct morphological defects, suggesting that similar GTPases in the same subfamily have unique roles in morphogenesis...
- Small GTP-binding proteinsY Takai
Department of Molecular Biology, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Japan
Physiol Rev 81:153-208. 2001..Cascades and cross-talks of small G proteins have also been clarified. In this review, functions of small G proteins and their modes of activation and action are described...
- Inhibition of myosin light chain kinase by p21-activated kinaseL C Sanders
Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Science 283:2083-5. 1999..These data indicate that MLCK is a target for PAKs and that PAKs may regulate cytoskeletal dynamics by decreasing MLCK activity and MLC phosphorylation...
- Regulation of NADPH oxidases: the role of Rac proteinsPeter L Hordijk
Department Molecular Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Circ Res 98:453-62. 2006..This review focuses on the role of the Rac1 and Rac2 GTPases in the activation of the various NOX family members...
- Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamicsD C Edwards
Department of Chemistry, University of California at San Diego, La Jolla 92093 0650, USA
Nat Cell Biol 1:253-9. 1999..A Pak1-specific inhibitor, corresponding to the Pak1 autoinhibitory domain, blocks LIM-kinase-induced cytoskeletal changes. Activated GTPases can thus regulate actin depolymerization through Pak1 and LIM-kinase...
- Rational design and characterization of a Rac GTPase-specific small molecule inhibitorYuan Gao
Division of Experimental Hematology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 101:7618-23. 2004..Thus, NSC23766 constitutes a Rac-specific small-molecule inhibitor that could be useful to study the role of Rac in various cellular functions and to reverse tumor cell phenotypes associated with Rac deregulation...
- The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contactsV M Braga
Medical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT, London, United Kingdom
J Cell Biol 137:1421-31. 1997..Our results provide new insights into the role of the small GTPases in the cadherin-dependent cell- cell contact formation and the remodelling of actin filaments in epithelial cells...
- Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cellsB Wojciak-Stothard
Ludwig Institute for Cancer Research, London, United Kingdom
J Cell Physiol 176:150-65. 1998..Our data suggest that Cdc42, Rac, and Rho are activated in a hierarchical cascade following stimulation with TNF-alpha leading to actomyosin-mediated cell retraction and formation of intercellular gaps...
- P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for RacHeidi C E Welch
Inositide Laboratory, Cambridge CB2 4AT, United Kingdom
Cell 108:809-21. 2002..P-Rex1 appears to be a coincidence detector in PtdIns(3,4,5)P3 and Gbetagamma signaling pathways that is particularly adapted to function downstream of heterotrimeric G proteins in neutrophils...
- Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegansJason M Kinchen
Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11743, USA
Nature 434:93-9. 2005....
- Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)KP J Keely
Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599 7365, USA
Nature 390:632-6. 1997..PI(3)K inhibition also disrupts actin structures, suggesting that activation of PI(3)K by Cdc42 and Rac1 alters actin organization, leading to increased motility and invasiveness...
- C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180Y C Wu
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Nature 392:501-4. 1998..We name this new family of proteins that function in the extension of cell surfaces the CDM (for CED-5, DOCK180 and MBC) family...
- PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1Takashi Nishimura
Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, Aichi 466 8550, Japan
Nat Cell Biol 7:270-7. 2005..We propose that the PAR-6-PAR-3 complex mediates Cdc42-induced Rac activation by means of STEF/Tiam1, and that this process seems to be required for the establishment of neuronal polarity...
- Rho GTPases and their effector proteinsA L Bishop
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, U K
Biochem J 348:241-55. 2000..The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of Rho GTPases in lower eukaryotes is making increasingly important contributions to this field...
- Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defenseA W Roberts
Howard Hughes Medical Institute, and Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
Immunity 10:183-96. 1999..Rac2 is an essential regulator of multiple specialized neutrophil functions...
- The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRFC S Hill
Transcription Laboratory, Imperial Cancer Research Fund Laboratories, London, England
Cell 81:1159-70. 1995..Functional Rho is required for regulated activity of the c-fos promoter. These results establish SRF as a nuclear target of a novel Rho-mediated signaling pathway...
- Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysisErik Sahai
Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
Nat Cell Biol 5:711-9. 2003..Combined blockade of extracellular proteases and ROCK negates the ability of tumour cells to switch between modes of motility and synergises to prevent tumour cell invasion...
- Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migrationShiro Suetsugu
Department of Biochemistry, Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
Dev Cell 5:595-609. 2003..Thus, WAVE2 is essential for leading edge extension for directed migration in general and WAVE1 is essential in MMP-dependent migration in ECM...
- Rho and Rac take center stageKeith Burridge
Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
Cell 116:167-79. 2004..Additionally, we will discuss how there is signaling crosstalk between family members and how various bacterial pathogens have developed strategies to manipulate Rho protein activity so as to enhance their own survival...
- A role for Rac in Tiam1-induced membrane ruffling and invasionF Michiels
The Netherlands Cancer Institute, Division of Cell Biology, Amsterdam
Nature 375:338-40. 1995..Moreover, T-lymphoma cells expressing V12Rac1 become invasive, indicating that the Tiam1-Rac signalling pathway could be operating in the invasion and metastasis of tumour cells...
- E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contactsEva M Kovacs
Department of Physiology and Pharmacology, School of Biomedical Science, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
J Biol Chem 277:6708-18. 2002..We propose that a key function of these cadherin-activated signals is to control adhesive contacts, probably via regulation of the actin cytoskeleton, which ultimately serves to mediate adhesive cell-cell recognition...
- Human p21-activated kinase (Pak1) regulates actin organization in mammalian cellsM A Sells
Fox Chase Cancer Centre, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
Curr Biol 7:202-10. 1997..This kinase is therefore a candidate effector for the changes in cell shape induced by growth factors...
- Stem cell depletion through epidermal deletion of Rac1Salvador Aznar Benitah
Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Science 309:933-5. 2005..We conclude that a pleiotropic regulator of cell adhesion and the cytoskeleton plays a critical role in controlling exit from the stem cell niche and propose that Rac and Myc represent a global stem cell regulatory axis...
- Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexesE Manser
Glaxo IMCB Group, Institute of Molecular and Cell Biology, National University of Singapore, Kent Ridge
Mol Cell Biol 17:1129-43. 1997..These data support our previous suggestions of a role for PAK downstream of both Cdc42 and Rac1 and indicate that PAK functions include the dissolution of stress fibers and reorganization of focal complexes...
- Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12Xiaochen Wang
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Science 302:1563-6. 2003..Our findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis...
- Activation of Rac1 by a Crk SH3-binding protein, DOCK180E Kiyokawa
Department of Pathology, National Institute of Infectious Diseases, Toyama, Shinjuku ku, Tokyo 162 8640, Japan
Genes Dev 12:3331-6. 1998..Dominant-negative Rac1 suppressed DOCK180-induced membrane spreading. These results strongly suggest that DOCK180 is a novel activator of Rac1 and involved in integrin signaling...
- Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by VavJ Han
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033 0800, USA
Science 279:558-60. 1998..Control of Vav in response to mitogens by the products of PI 3-kinase suggests a mechanism for Ras-dependent activation of Rac...
- Rac function and regulation during Drosophila developmentSatoko Hakeda-Suzuki
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Nature 416:438-42. 2002..Different Rac activators thus act in different developmental processes. The specific cellular response to Rac activation may be determined more by the upstream activator than the specific Rac protein involved...
- Integrin-specific activation of Rac controls progression through the G(1) phase of the cell cycleA Mettouchi
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Mol Cell 8:115-27. 2001..This process is mediated by SOS and PI-3K and requires coordinate upstream signals through Shc and FAK. These results indicate that Rac is a crucial mediator of the integrin-specific control of cell cycle in endothelial cells...
- Regulation of innate immunity by Rho GTPasesGary M Bokoch
Department of Immunology and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Trends Cell Biol 15:163-71. 2005..An understanding of the biochemical basis for such distinct activities should provide novel insights into the molecular details of Rho GTPase function and regulation in innate immunity...
- A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathwaysY Horii
Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
EMBO J 13:4776-86. 1994..Of the tissues examined, expression of ost was the highest in brain and could be localized to neurons and alpha-tanycytes, suggesting that Ost may participate in axonal transport in these specialized cells...
- Ras family GTPases control growth of astrocyte processesD Kalman
Department of Microbiology and Immunology, G W Hooper Foundation Laboratories, University of California at San Francisco, San Francisco, California 94143, USA
Mol Biol Cell 10:1665-83. 1999....
- Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cellsYasuji Ryu
Department of Physiology, Kanazawa University, Graduate School of Medicine, Kanazawa, Ishikawa, Japan
Circ Res 90:325-32. 2002..These results together indicate that Edg isoform-specific, negative or positive regulation of cellular Rac activity is critically involved in S1P-mediated bimodal regulation of cell motility in SMCs and HUVECs...
- Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membraneTomoyo Okada
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Cell Biol 171:361-71. 2005..These results provide a framework for understanding the tumor suppressor function of Merlin and indicate that Merlin mediates contact inhibition of growth by suppressing recruitment of Rac to matrix adhesions...
- Functions of Rac GTPases during neuronal developmentIvan de Curtis
Cell Adhesion Unit, San Raffaele Scientific Institute, Milan, Italy
Dev Neurosci 30:47-58. 2008....
- Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in DrosophilaT P Newsome
Research Institute of Molecular Pathology, Vienna, Austria
Cell 101:283-94. 2000..We propose that distinct signals transduced via Trio and Dock act combinatorially to activate Pak in spatially restricted domains within the growth cone, thereby controlling the direction of axon extension...
- MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cellsA Toure
Institut Cochin de Genetique Moleculaire, INSERM Unité 257, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
J Biol Chem 273:6019-23. 1998..Since rotundRacGAP deletion leads to male sterility in the fruit fly, the mgcRacGAP gene may prove likewise to play a key role in mammalian male fertility...
- Rac activation and inactivation control plasticity of tumor cell movementVictoria Sanz-Moreno
Institute of Cancer Research, Cancer Research UK Centre for Cell and Molecular Biology, 237 Fulham Road, London SW3 6JB, UK
Cell 135:510-23. 2008..We demonstrate tight interplay between Rho and Rac in determining different modes of tumor cell movement, revealing how tumor cells switch between different modes of movement...
- Rac1 signalling in the Drosophila larval cellular immune responseMichael J Williams
Umeå Centre for Molecular Pathogenesis UCMP, Umea University, S 901 87, Umea, Sweden
J Cell Sci 119:2015-24. 2006..From these data we conclude that Rac1 induces Bsk activity and stable actin formation for cellular immune activation, leading to sessile hemocyte release and an increase in the number of circulating hemocytes...
- Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compassChun Xiang Sun
Faculty of Dentistry, University of Toronto, Rm 241, 150 College St, Toronto, ON, Canada M5S 1A8
Blood 104:3758-65. 2004....
- GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migrationRi ichiroh Manabe
Department of Cell Biology, University of Virginia, Charlottesville VA 22908, USA
J Cell Sci 115:1497-510. 2002..Thus, GIT1 is a component of a motile, multimolecular complex that traffics a set of signaling components to specific locations in the cell where they regulate localized activities...
- Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathwaysJulien Cau
MRC Laboratory for Molecular Cell Biology, Cancer Research UK Oncogene and Signal Transduction Group, University College London
J Cell Sci 118:2579-87. 2005..We conclude that in migrating cells, Cdc42 co-ordinately regulates the polarity of the microtubule and actin cytoskeletons through two distinct pathways...
- Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganizationN Yang
Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
Nature 393:809-12. 1998..Furthermore, insulin and an active form of Rac increase the activity of LIMK-1. Taken together, our results indicate that LIMK-1 participates in Rac-mediated actin cytoskeletal reorganization, probably by phosphorylating cofilin...
- Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cellsSandra van Wetering
Department of Experimental Immunohematology, Academic Medical Center, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
J Cell Sci 115:1837-46. 2002....
- Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasionL M Shaw
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Cell 91:949-60. 1997..The small G protein Rac is required downstream of PI3K for invasion. These studies define a mechanism by which the alpha6beta4 integrin promotes carcinoma invasion and invoke a novel function for PI3K signaling...
- Integrin signaling to the actin cytoskeletonKris A DeMali
Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
Curr Opin Cell Biol 15:572-82. 2003..Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion...
- Rho GTPases are over-expressed in human tumorsG Fritz
Institute of Toxicology, Division of Applied Toxicology, University of Mainz, Germany
Int J Cancer 81:682-7. 1999..Overall, increase in the amount of Rho GTPases, in particular RhoA, appears to be a frequent event in different types of human tumors. This supports the view that Rho GTPases are involved in human carcinogenesis...
- Synapse formation is regulated by the signaling adaptor GIT1Huaye Zhang
Department of Cell Biology, University of Virginia, Charlottesville, VA 22908 0732, USA
J Cell Biol 161:131-42. 2003....
- Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPasesY Ren
Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 273:34954-60. 1998..These results suggest that GEF-H1 may have a direct role in activation of Rac and/or Rho and in bringing the activated GTPase to specific target sites such as microtubules...
- A Rac switch regulates random versus directionally persistent cell migrationRoumen Pankov
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 170:793-802. 2005..Total Rac1 activity can therefore provide a regulatory switch between patterns of cell migration by a mechanism distinct from chemotaxis...
- Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiencyD A Williams
Department of Pediatrics, Wells Center for Pediatric Research, Howard Hughes Medical Institute, Indiana University School of Medicine, Indianapolis, IN 46202 5225, USA
Blood 96:1646-54. 2000..Blood. 2000;96:1646-1654)..
- Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein familyT H Chuang
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 92:10282-6. 1995..These data suggest the multifunctional Bcr and Abr proteins might interact simultaneously and/or sequentially with members of the Rho family to regulate and coordinate cellular signaling...
- Rho family GTPases bind to phosphoinositide kinasesK F Tolias
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
J Biol Chem 270:17656-9. 1995....
- Effects of cell tension on the small GTPase RacAkira Katsumi
Division of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 158:153-64. 2002..We hypothesize that regulation of Rac activity by tension may be important for motility, polarization, and directionality of cell movement...
- Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cellsShusaku Kurisu
Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Oncogene 24:1309-19. 2005..Thus, WAVE2 acts as the primary effector downstream of Rac to achieve invasion and metastasis, suggesting that suppression of WAVE2 activity holds a promise for preventing cancer invasion and metastasis...
- Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutationD R Ambruso
Bonfils Blood Center, Denver, CO 80220, USA
Proc Natl Acad Sci U S A 97:4654-9. 2000..These data represent the description of an inhibitory mutation in a member of the Rho family of GTPases associated with a human immunodeficiency syndrome...
- Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxisKersi N Pestonjamasp
Departments of Immunology and Cell Biology IMM14, The Scripps Research Institute, La Jolla, CA, USA
Blood 108:2814-20. 2006..We conclude that Rac plays both positive and negative roles in the organization of the Rhomyosin "backness" program, thereby promoting stable polarity in chemotaxing neutrophils...
- Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndromeP Aspenstrom
Department of Zoological Cell Biology, Wenner Gren Institute, Stockholm, Sweden
Curr Biol 6:70-5. 1996..In order to examine more closely the mechanisms underlying the diverse functions of Rho GTPases in mammalian cells, we searched for downstream targets of these proteins...
- ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblastsTakahiro Tsuji
Department of Pharmacology, Kyoto University Faculty of Medicine, 606 8501, Japan
J Cell Biol 157:819-30. 2002..Thus, these results have revealed the Rho-dependent Rac activation signaling that is mediated by mDia1 through Cas phosphorylation and antagonized by the action of ROCK...
- CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegansP W Reddien
Howard Hughes Medical Institute, Department of Biology, 68 425, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nat Cell Biol 2:131-6. 2000..We propose that CED-2/CrkII and CED-5/DOCK180 function to activate CED-10/Rac in a GTPase signalling pathway that controls the polarized extension of cell surfaces...
- The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesionsAngeliki Malliri
Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Biol Chem 279:30092-8. 2004..These studies indicate that the Rac activator Tiam1 is essential for the formation as well as the maintenance of cadherin-based adhesions...
- Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1David García-Bernal
Department of Immunology, Centro de Investigaciones Biologicas, CSIC, 28006 Madrid, Spain
Mol Biol Cell 16:3223-35. 2005..These results indicate that activation of Vav1-Rac signaling pathway by CXCL12 represents an important inside-out event controlling efficient up-regulation of alpha4beta1-dependent T lymphocyte adhesion...
- Deficiency of small GTPase Rac2 affects T cell activationH Yu
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
J Exp Med 194:915-26. 2001..The phenotypic similarity of Rac2(-/-) to Vav(-/-) cells implicates Rac2 as a downstream mediator of Vav signaling...
- Pak to the futureS Bagrodia
Dept of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
Trends Cell Biol 9:350-5. 1999..We present these recent findings and consider how these new regulators and targets could explain some of the cellular effects that have been attributed to Pak family members...
- Genetic ablation of Rac1 in cartilage results in chondrodysplasiaGuoyan Wang
CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
Dev Biol 306:612-23. 2007..In summary, these data identify a novel, essential and tissue-specific role of Rac1 in skeletal development and demonstrate that Rac1 deficiency affects numerous regulatory pathways in cartilage...
- Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiationB Li
Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520 8011, USA
Science 288:2219-22. 2000..Moreover, T cells from Rac2-/- mice showed decreased IFN-gamma production under TH1 conditions in vitro. Thus, Rac2 activates TH1-specific signaling and IFN-gamma gene expression...
- Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?Orion D Weiner
Department of Cell Biology, Harvard Medical School, 240 Longwood Ave C 1, 502, Boston, Massachusetts 02115, USA
Curr Biol 12:R429-31. 2002..P-Rex1 is synergistically activated by PIP(3) and Gbetagamma and may act as a coincidence detector for these signaling molecules...
- Rho family GTP-binding proteins in growth cone signallingL Luo
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, California 94143, USA
Curr Opin Neurobiol 7:81-6. 1997..Recent evidence suggests that they may also be important components of the signalling pathways that link the reception of extracellular cues to the regulation of the cytoskeleton in neuronal growth cones...
- Phosphoinositide 3-kinase-dependent activation of RacHeidi C E Welch
Inositide Laboratory, Signalling Programme, The Babraham Institute, Cambridge CB2 4AT, UK
FEBS Lett 546:93-7. 2003..Vice versa, Rac can also stimulate the activation of PI3K, although the mechanism for this is unclear. We review here the evidence that links PI3K and Rac signalling pathways...
- DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1Terukazu Sanui
Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Blood 102:2948-50. 2003....
- Drosophila melanogaster Rac2 is necessary for a proper cellular immune responseMichael J Williams
Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
Genes Cells 10:813-23. 2005..Finally, larger cells known as lamellocytes attach to the capsule but also fail to spread, and there is a lack of melanization. From these results it appears that Rac2 is necessary for the larval cellular immune response...
- P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migrationIvette Hernández-Negrete
Department of Pharmacology, CINVESTAV IPN, Apartado Postal 14 740, Mexico DF, 07000 Mexico
J Biol Chem 282:23708-15. 2007..mTORC2 has been described as the catalytic complex that phosphorylates AKT/PKB at Ser-473 and elicits activation of Rho GTPases and cytoskeletal reorganization. Thus, P-Rex1 links mTOR signaling to Rac activation and cell migration...
- Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerinBertram Canagarajah
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
Cell 119:407-18. 2004..Phospholipid binding to the C1 domain triggers the cooperative dissociation of these interactions, allowing the N terminus to move out of the active site and thereby activating the enzyme...
- CAS/Crk coupling serves as a "molecular switch" for induction of cell migrationR L Klemke
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
J Cell Biol 140:961-72. 1998..Thus, CAS/Crk assembly serves as a "molecular switch" for the induction of cell migration and appears to contribute to the invasive property of tumors...
- Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complexEnrico Brugnera
Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
Nat Cell Biol 4:574-82. 2002..We can also detect a trimeric ELMO1 Dock180 Rac1 complex and ELMO augments the interaction between Dock180 and Rac. We propose that the Dock180 ELMO complex functions as an unconventional two-part exchange factor for Rac...
- Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating RhoM H Driessens
MRC Laboratory for Molecular Cell Biology, Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, United Kingdom
Curr Biol 11:339-44. 2001..Our findings that plexin-B signaling to the cytoskeleton is both Rac and Rho dependent form a starting point for unraveling the mechanism by which semaphorins and plexins control axon guidance and cell migration...
- Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activityD Diekmann
Medical Research Council Laboratory for Molecular Cell Biology, University College London, UK
Science 265:531-3. 1994..Modified forms of Rac with mutations in the effector site did not stimulate oxidase activity or bind to p67phox. Thus, p67phox appears to be the Rac effector protein in the NADPH oxidase complex...
- A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPasesP D Burbelo
Medical Research Council Laboratory for Molecular Cell Biology, University College London, United Kingdom
J Biol Chem 270:29071-4. 1995..These results indicate that proteins containing the CRIB motif bind to Cdc42 and/or Rac in a GTP-dependent manner, and they may, therefore, participate in downstream signaling...
- Rac inhibition reverses the phenotype of fibrotic fibroblastsShi wen Xu
Centre for Rheumatology, Department of Medicine, University College London Royal Free Campus, London, United Kingdom
PLoS ONE 4:e7438. 2009..The basis for this phenomenon is poorly understood, and is a necessary prerequisite for developing novel, rational anti-fibrotic strategies...
- The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1Lorraine C Santy
Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
Curr Biol 15:1749-54. 2005..Together, these data suggest that ARNO and ARF6 coordinate with the Dock180/Elmo complex to promote Rac activation at the leading edge of migrating cells...
- Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunitsKirsti Hill
Inositide Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
J Biol Chem 280:4166-73. 2005....
- Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomainEmilio Hirsch
Dipartimento di Genetica, Biologia, e Biochimica, Universita di Torino, 10126 Torino, Italy
J Cell Biol 157:481-92. 2002..Altogether, our data provide the evidence for an epistatic interaction between the beta1 integrin cytoplasmic domain and Rac, and indicate that this anchorage-dependent signaling pathway is crucial for cell growth control...
- CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X proteinAnnette Schenck
Department of Molecular Pathology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Boite Postale 10142, 67404 Illkirch, Cedex, France
Neuron 38:887-98. 2003..CYFIP interacts biochemically and genetically with dFMR1 and dRac1. Finally, CYFIP acts as a dRac1 effector that antagonizes FMR1 function, providing a bridge between signal-dependent cytoskeleton remodeling and translation...
- Redox-dependent downregulation of Rho by RacAnjaruwee S Nimnual
Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Nat Cell Biol 5:236-41. 2003..Our findings define a novel mechanism for the coupling of changes in cellular redox state to the control of actin cytoskeleton rearrangements by Rho GTPases...
- Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMOColin D deBakker
Department of Microbiology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
Curr Biol 14:2208-16. 2004..However, the components upstream of ELMO and Dock180 during engulfment remain elusive...
- Spatial and temporal analysis of Rac activation during live neutrophil chemotaxisElisabeth M Gardiner
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Biol 12:2029-34. 2002..These data establish that Rac GTPase is spatially and temporally regulated to coordinate leading-edge extension and tail retraction during a complex motile response, the chemotaxis of human neutrophils...
- Regulation of cancer cell motility through actin reorganizationDaisuke Yamazaki
Department of Biochemistry, Institute of Medical Science, University of Tokyo, Minato ku, Japan
Cancer Sci 96:379-86. 2005..Inhibition of Rho family small GTPase signaling suppresses the migration and invasion of cancer cells. Thus, control of cell migration via the actin cytoskeleton provides the possibility of regulating cancer cell invasion and metastasis...
- Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cellsF C Yang
Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
Immunity 12:557-68. 2000..These results suggest that Rac2 plays a unique role in multiple cellular functions and describe an essential role for Rac2 in growth factor-dependent survival and expression of BAD/Bcl-XL...
- Rac1 expression by fibroblasts is required for tissue repair in vivoShangxi Liu
Department of Physiology and Pharmacology, Division of Oral Biology, Schulich School of Medicine and Dentistry, Canadian Institute of Health Research Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario, Canada
Am J Pathol 174:1847-56. 2009..Thus, Rac1 is an essential signaling integrator that is required for normal wound healing and dermal homeostasis...
- Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamicsAnjana Nayal
Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
J Cell Biol 173:587-9. 2006..These adhesions appear to be regulated by the GIT1-PIX-PAK module near the leading edge...
- Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindinHong Li
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
EMBO J 25:4097-107. 2006..These results suggest that mindin-integrin interactions play a key role in regulating Rho GTPase expression in DCs and DC priming of T lymphocytes...
- Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPaseCeline DerMardirossian
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Mol Cell 15:117-27. 2004..These results support a role for Pak1-mediated RhoGDI phosphorylation as a mechanism for Cdc42-mediated Rac activation, and suggest the possibility of Rac-induced positive feed-forward regulation of Rac activity...
- A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteinsM Agnel
Laboratoire de Génétique et Biologie Cellulaires, Centre National de la Recherche Scientifique, Marseille, France
Mol Cell Biol 12:5111-22. 1992..In addition to being expressed in the imaginal discs, the m1.7 racGAP transcript was detected in developmentally specific germ line cells of the testes, the primary spermatocytes...
- Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of DrosophilaS Eaton
Programme in Cell Biology, European Molecular Biology Laboratory, Heidelberg, Germany
J Cell Biol 135:1277-89. 1996..During hair formation, the apical microtubules that point distally elongate and fill the emerging wing hair. As the hair elongates, junctional proteins are reorganized on the proximal and distal edges of each cell...
- Molecular requirements for actin-based lamella formation in Drosophila S2 cellsStephen L Rogers
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
J Cell Biol 162:1079-88. 2003..Our results have identified an essential set of proteins involved in actin dynamics during lamella formation in Drosophila S2 cells...
- RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42HsC Gauthier-Rouviere
IGMM, CNRS UMR5535, route de Mende, 34293 Montpellier Cedex 05 France
Mol Biol Cell 9:1379-94. 1998..Therefore, our data demonstrate that RhoG controls a pathway that requires the microtubule network and activates Rac1 and Cdc42Hs independently of their growth factor signaling pathways...
- The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogueM Hirshberg
Division of Protein Structure, National Institute for Medical Research, Mill Hill, London, UK
Nat Struct Biol 4:147-52. 1997..38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family...
- HTS For Inhibitors of NADPH Oxidase 1 (Nox1)Gary Bokoch; Fiscal Year: 2008..Such inhibitors will be useful to investigate Nox1 biology, and as potential therapeutic agents in inflammatory diseases and cancer. [unreadable] [unreadable] [unreadable]..
- REGULATION OF NEUTROPHIL RECEPTOR G PROTEIN INTERACTIONSGary Bokoch; Fiscal Year: 2009..Spatio-temporal evaluation of Rho activation will be related to Rac2 activity, as well as specific aspects of a) chemoattractant receptor signaling, b) motile behavior, and c) actin-myosin cytoskeletal dynamics. ..
- CONTROL OF PHAGOCYTE NADPH OXIDASE BY CYTOSOLIC PROTEINSGary Bokoch; Fiscal Year: 2005....
- RhoH GTPase in blood cell and cancer developmentYi Gu; Fiscal Year: 2006..Given the lineage-restricted expression of RhoH such an observation could have important therapeutic implication. ..
- Role of Vav family proteins in cell signaling and cancerXOSE BUSTELO; Fiscal Year: 2009..abstract_text> ..
- STRUCTURE/FUNCTION ANALYSIS OF PHAGOCYTE PROTEINSMary Dinauer; Fiscal Year: 2009..These studies will provide further insight into the superoxide- generating system of the phagocyte, which may lead to new approaches in modulating superoxide formation in the inflammatory response and host defense. ..
- Role of Prostaglandins & Phospholipase A in melanocytesGlynis Scott; Fiscal Year: 2009..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
- Role of Synaptojanin 2 in Tumor Cell InvasionMarc Symons; Fiscal Year: 2009..The molecular analysis of the functions of SJ2 in the formation of lamellipodia and invadopodia and tumor cell migration and invasion will significantly expand our current understanding of the role of Rac1 in malignant transformation. ..
- Rho GtPase and Cell Cycle Regulation in Breast CancerCatherine Welsh; Fiscal Year: 2005..Welsh's progression to the status of independent investigator. ..
- Identification of RhoGEFs as novel therapeutic targets for malignant gliomaMarc Symons; Fiscal Year: 2008..We also expect that we will obtain significant clinical information that will aid in the validation of these invasion genes. [unreadable] [unreadable] [unreadable] [unreadable]..
- 2005 Phagocytes Gordon ConferenceMary Dinauer; Fiscal Year: 2005..The program will provide opportunities for participation of scientists at all levels and we will particularly promote the participation of junior investigators, postdoctoral trainees and "new investigators to the field". ..
- Mechanochemical regulation of endothelial permeabilityKonstantin Birukov; Fiscal Year: 2007....
- Wnt Proteins During Intestinal Repair and RegenerationCalvin Kuo; Fiscal Year: 2009....
- 2008 NOX Family NADPH Oxidases Gordon ConferenceWILLIAM NAUSEEF; Fiscal Year: 2008..End of Abstract) [unreadable] [unreadable] [unreadable]..
- Biosynthesis, structural organization, and function of NOX proteinsWILLIAM NAUSEEF; Fiscal Year: 2007..abstract_text> ..
- Inhibitory Signaling via FcgRIIB Receptor on B CellsKodi Ravichandran; Fiscal Year: 2008....
- Apoptotic Cell Recognition & Clearance 2007 Gordon Research ConferenceKodi Ravichandran; Fiscal Year: 2007..The meeting is purposely held in alternative years with[unreadable] the Apoptosis meeting to encourage participation by all of those with an interest in cell death. ..
- Role of integrin signaling in gonad functionsMyeongwoo Lee; Fiscal Year: 2007..These studies will additionally advance our knowledge on the role of cell-ECM interaction in gonad development and functions. ..
- Regulation of CNS Angiogenesis By GPR124Calvin Kuo; Fiscal Year: 2009..Finally, conditional approaches to GPR124 inactivation will be pursued using adenoviral and conditional knockout strategies, to facilitate the eventual study of GPR124 function in fully adult organisms. ..
- The Role of Rho GTPases in Ethanol-Induced Liver InjuryCourtney Schaffert; Fiscal Year: 2007..Our studies have begun to characterize how alcohol impairs these functions. Thus, results from the proposed research could lead to effective treatment strategies in alcoholic liver disease. [unreadable] [unreadable] [unreadable]..
- Phagocytosis of apoptotic cells: Signaling via GULPKodi Ravichandran; Fiscal Year: 2007..In these mouse studies, we will determine the effect on engulfment due to the absence of GULP, or disrupted GULP function, and any potential effects on autoimmunity due to defective engulfment. ..
- Inverted two photon laser scanning microscope for host defenseMichael Dustin; Fiscal Year: 2008..The impact on public health will be to develop better strategies to fight infections and reduce the incidence of pathogen triggered autoimmunity. [unreadable] [unreadable] [unreadable]..
- Protein Prenyltransferases in Glucose-Stimulated Insulin SecretionAnjaneyulu Kowluru; Fiscal Year: 2010....
- Versatile scaffolds to visualize endogenous protein activation in living cellsKLAUS MICHAEL HAHN; Fiscal Year: 2010..PAK, JNK, and ERK2 are each on a different, parallel pathway downstream of Src. The spatio-temporal regulation of this signaling network to produce different cellular responses will be examined. ..
- Modulation of Host Cell Functions by Coxiella burnetiiCraig R Roy; Fiscal Year: 2010..These studies will elucidate pathogenic determinants that allow host cell infection by Coxiella and reveal intracellular infection strategies employed by this important pathogen. ..
- Lipid Raft Microdomains in Neutrophil FunctionROBERT GARY SITRIN; Fiscal Year: 2010..Hopefully, targeting the function of lipid raft microdomains will engender new therapeutic strategies for enhancing antimicrobial defenses and suppressing the deleterious effects of acute inflammation. ..
- ImmunoreceptorsMichael Dustin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- The Role of CBFb-MYH11 in Acute Myeloid LeukemiaJames C Mulloy; Fiscal Year: 2010..To identify specific signals that will cooperate in the transformation to acute leukemia, defined eenetic elements and saturatine retroviral mutaeenesis will be used. ..
- Reactive Oxygen Species in Anti-Viral Airway Host DefenseJeffrey Friedman; Fiscal Year: 2008..Our studies will show if oxidases are a promising target for therapeutic drug development. [unreadable] [unreadable] [unreadable] [unreadable]..
- ERM and Rho Signal Pathways in T Cell Immune SenescenceGONZALO GARCIA; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Signaling by p21-activated protein kinasesJONATHAN D CHERNOFF; Fiscal Year: 2010....
- Specific Biochemical Inactivation of Oncogenic RasJeffrey Settleman; Fiscal Year: 2008..Together, the proposed studies are expected to lead to the eventual development of a novel therapeutic approach for achieving specific targeting of human tumors that harbor oncogenic mutant forms of Ras. ..
- Spatial regulation of Protein Kinase A in cell migrationAlan K Howe; Fiscal Year: 2010..abstract_text> ..
- Chemokine Receptor Chimeras by Synthetic Gene LibraryMichael Dustin; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Dynamics of MAPK Phosphorylation in Living CellsKlaus Hahn; Fiscal Year: 2004..The fundamental processes controlled by Erk, including motility, apoptosis, and proliferation, are critical to normal homeostasis and relevant to many diseases and immune function. ..
- REGULATION OF P21-ACTIVATED KINASESJonathan Chernoff; Fiscal Year: 2004..Understanding the molecular basis for this regulation is not only of intrinsic scientific interest but is also likely to be relevant to important human diseases such as metastatic cancer. ..
- The NF2 gene: elucidation of tumor suppressor functionJOSEPH KISSIL; Fiscal Year: 2004..This should lead to a better understanding of merlin function in normal cells and the consequences of its loss in tumor development. Such information will directly assist in the search for effective therapies. ..
- ROLE OF PROTEIN PHOSPHATASES IN INSULIN SECRETIONAnjaneyulu Kowluru; Fiscal Year: 2004....
- The Urokinase-CD87 System in Macrophage ActivationRobert Sitrin; Fiscal Year: 2004....
- RHO GTPASE SIGNALING IN EMBRYO MORPHOGENESISJeffrey Settleman; Fiscal Year: 2003..abstract_text> ..
- PKC Theta--A Novel Drug Target in T Cell LeukemiasAmnon Altman; Fiscal Year: 2003..abstract_text> ..
- Pruning of Motor Neuronal ArborsJoyce Fernandes; Fiscal Year: 2003..These studies will have implications for better understanding the neurodevelopmental basis of diseases such as epilepsy, schizophrenia and Rett's syndrome, where pruning is thought to be defective. ..
- REGULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN KIDNEYBRUCE KONE; Fiscal Year: 2002....
- SPHINGOLIPID METABOLITE, SPHINGOSINE 1 PHOSPHATESarah Spiegel; Fiscal Year: 2002..This proposal provides a new paradigm for dissecting the complex interplay between intra and extracellular actions of sphingosine-1-phosphate. ..
- Regulation of the Actin Cytoskeleton in Dendric SpinesPeter Penzes; Fiscal Year: 2002..serine/threonine phosphorylation, and generate initial information about the types of protein kinases involved. Together, these experiments will provide a basis for future studies of regulation of kalirin-7 and spine morphogenesis. ..
- REGULATION OF PHOSPHOLIPASE CT Harden; Fiscal Year: 2002..Completion of the work described in this proposal should considerably extend knowledge of the identify, specificity, and mechanism of interaction of the component proteins of the receptor-regulated inositol lipid signalling pathway. ..
- Molecular Cloning of the Wilms tumor Gene from 7p15-21Khalid Sossey Alaoui; Fiscal Year: 2004..Understanding the nature of the genetic events which allow these cells to escape their normal growth regulation may also provide an opportunity for therapeutic intervention. ..
- FASEB Summer Research Conference on Small G-ProteinsJeffrey Settleman; Fiscal Year: 2004..The conference will cover the biochemical, structural, and functional aspects of the various small GTPases and their regulators and targets. ..
- Phagocyte Contact Response in Aspergillosis ImmunityJAMES BURRITT; Fiscal Year: 2005..fumigatus resting conidia, swollen conidia, and hyphae with a peptide library. This information will be used to suggest mechanisms of attachment in this host-pathogen relationship ..
- A Growth-Regulating Protein Tyrosine PhosphataseJonathan Chernoff; Fiscal Year: 2007..Importantly, it also may point the way to the development of new therapeutic agents for diseases such as diabetes and cancer. ..
- REGULATION OF SUPEROXIDE PRODUCTION BY HUMAN NEUTROPHILSJeffrey Friedman; Fiscal Year: 2007..These studies may ultimately lead to new pharmacological methods for controlling oxygen radical-mediated tissue damage as well as an improved understanding of the pathophysiology of CGD. ..
- 2006 NOX Family NADPH Oxidases Gordon ConferenceWILLIAM NAUSEEF; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Regulated cytoskeletal dynamics in the secretory pathwayMark Stamnes; Fiscal Year: 2006..abstract_text> ..
- VEGF-dependent and - Independent Anti-angiogenic TherapyCalvin Kuo; Fiscal Year: 2006..Moreover, these humanized receptors will be expressed from regulated adenoviruses to confer an additional degree of safety as a prelude to eventual clinical use. ..
- G PROTEIN SUBUNITS--CELL BIOLOGY AND SIGNALINGHenry Bourne; Fiscal Year: 2001..4) Define interactions of the G-alpha with three proteins - actin, caveolin and members of the G-alpha-interacting protein (GAIP) family-that may inhibit G protein signaling by interacting with and sequestering G-alpha subunit. ..
- Regulation and Functin of the p190 RhoGAPsJeffrey Settleman; Fiscal Year: 2006..This is an important step toward establishing an accurate picture of the regulatory mechanisms for small GTPases in vivo, and the nature of their dysregulation in human cancers. ..
- REGULATION OF HUMAN PHAGOCYTE FUNCTION BY RAC PROTEINSUlla Knaus; Fiscal Year: 2006..These studies will yield novel insights into the overall control of oxidant formation by innate immune cells. ..
- CHAPERONES AND PROTEIN BIOSYNTHESIS IN MYELOID CELLSWILLIAM NAUSEEF; Fiscal Year: 2005..The applicants believe that these will define principles that apply not only to these specific myeloid proteins but to proteins in general that acquire heme in the ER. ..
- Role of AML1/ETO in Hematopoiesis and LeukemogenesisJAMES MULLOY; Fiscal Year: 2005..The establishment of a small animal model of AML will greatly enhance our ability to develop and test treatment strategies and drugs that may be useful in the therapy of AML. ..
- The Submembranous Cytoskeleton in Neutrophil ActivationWILLIAM NAUSEEF; Fiscal Year: 2005..Fundamental principles elucidated already have been applied to studies of specific host-pathogen interactions. ..
- The Role of MLL-AF9 in Acute Myeloid LeukemiaJames C Mulloy; Fiscal Year: 2010..RELEVANCE (See instructions): We have recently shown that human blood stem cells can be induced to make leukemia upon introduction ..
- G protein signal integration by multifunctional proteinsT Harden; Fiscal Year: 2006..abstract_text> ..
- Molecular Mechanisms of MIG-10 function in axon guidanceChristopher Quinn; Fiscal Year: 2005..Information from this project will be beneficial in understanding disorders of the nervous system as well as the molecular basis of cancer. ..