rho gtp binding proteins

Summary

Summary: A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organization, gene expression and cell cycle progression. This enzyme was formerly listed as EC 3.6.1.47.

Top Publications

  1. ncbi Rho GTPases in cell biology
    Sandrine Etienne-Manneville
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, Cancer Research UK Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Nature 420:629-35. 2002
  2. ncbi Rho GTPases: biochemistry and biology
    Aron B Jaffe
    MRC Laboratory for Molecular Cell Biology, Cancer Research UK, Oncogene and Signal Transduction Group, United Kingdom
    Annu Rev Cell Dev Biol 21:247-69. 2005
  3. pmc Rho GTPases and their effector proteins
    A L Bishop
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, U K
    Biochem J 348:241-55. 2000
  4. ncbi GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
    Kent L Rossman
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Rev Mol Cell Biol 6:167-80. 2005
  5. ncbi Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    Erik Sahai
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Nat Cell Biol 5:711-9. 2003
  6. ncbi Rho GTPases and cell migration
    A J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, UK
    J Cell Sci 114:2713-22. 2001
  7. ncbi Mammalian Rho GTPases: new insights into their functions from in vivo studies
    Sarah J Heasman
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London, UK
    Nat Rev Mol Cell Biol 9:690-701. 2008
  8. ncbi Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again
    Donna J Webb
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Nat Cell Biol 4:E97-100. 2002
  9. ncbi Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
    Anja Schmidt
    MRC Laboratory for Molecular Cell Biology, Cancer Research UK Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, UK
    Genes Dev 16:1587-609. 2002
  10. pmc Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding
    D Michaelson
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Cell Biol 152:111-26. 2001

Research Grants

Detail Information

Publications279 found, 100 shown here

  1. ncbi Rho GTPases in cell biology
    Sandrine Etienne-Manneville
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, Cancer Research UK Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Nature 420:629-35. 2002
    ..With spatial and temporal activation of multiple switches factored in, it is not surprising to find Rho GTPases having such a prominent role in eukaryotic cell biology...
  2. ncbi Rho GTPases: biochemistry and biology
    Aron B Jaffe
    MRC Laboratory for Molecular Cell Biology, Cancer Research UK, Oncogene and Signal Transduction Group, United Kingdom
    Annu Rev Cell Dev Biol 21:247-69. 2005
    ..In the first part of this review, we present the best characterized of these biochemical pathways; in the second part, we attempt to integrate these molecular details into a biological context...
  3. pmc Rho GTPases and their effector proteins
    A L Bishop
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, U K
    Biochem J 348:241-55. 2000
    ..The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of Rho GTPases in lower eukaryotes is making increasingly important contributions to this field...
  4. ncbi GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
    Kent L Rossman
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Rev Mol Cell Biol 6:167-80. 2005
    ..The failure to do so can have significant consequences and is reflected in the aberrant function of Dbl-family GEFs in some human diseases...
  5. ncbi Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    Erik Sahai
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Nat Cell Biol 5:711-9. 2003
    ..Combined blockade of extracellular proteases and ROCK negates the ability of tumour cells to switch between modes of motility and synergises to prevent tumour cell invasion...
  6. ncbi Rho GTPases and cell migration
    A J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, UK
    J Cell Sci 114:2713-22. 2001
    ..There is also increasing evidence that Rho proteins affect the organization of the microtubule and intermediate filament networks and that this is important for cell migration...
  7. ncbi Mammalian Rho GTPases: new insights into their functions from in vivo studies
    Sarah J Heasman
    Randall Division of Cell and Molecular Biophysics, King s College London, Guy s Campus, London, UK
    Nat Rev Mol Cell Biol 9:690-701. 2008
    ..The recent availability of knockout mice for several members of the Rho family reveals new information about their roles in signalling to the cytoskeleton and in development...
  8. ncbi Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again
    Donna J Webb
    Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Nat Cell Biol 4:E97-100. 2002
    ..Even though understanding these processes is challenging, important insights are beginning to emerge, and the technology to facilitate significant advances in this area is now in place...
  9. ncbi Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
    Anja Schmidt
    MRC Laboratory for Molecular Cell Biology, Cancer Research UK Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, UK
    Genes Dev 16:1587-609. 2002
  10. pmc Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding
    D Michaelson
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Cell Biol 152:111-26. 2001
    ..Thus, despite the common essential feature of the CAAX (prenylation, AAX tripeptide proteolysis, and carboxyl methylation) motif, the subcellular localizations of Rho GTPases, like their functions, are diverse and dynamic...
  11. ncbi Analysis of activated GAPs and GEFs in cell lysates
    Rafael Garcia-Mata
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA
    Methods Enzymol 406:425-37. 2006
    ..This assay can be used to identify GEFs, GAPs, and effectors involved in specific cellular pathways to determine their GTPase specificity and to monitor the temporal activation of GEFs and GAPs in response to upstream signals...
  12. pmc RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
    Anne Hakem
    Campbell Family Institute for Breast Cancer Research, Toronto, Ontario, M5G 2C1, Canada
    Genes Dev 19:1974-9. 2005
    ..We demonstrate that loss of RhoC does not affect tumor development but decreases tumor cell motility and metastatic cell survival leading to a drastic inhibition of metastasis...
  13. ncbi Rho GTPases in neuronal morphogenesis
    L Luo
    Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Nat Rev Neurosci 1:173-80. 2000
    ..Mutations in these signalling pathways have been reported in human neurological diseases, which underscores their importance in the development and function of the nervous system...
  14. ncbi Small GTP-binding proteins
    Y Takai
    Department of Molecular Biology, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Japan
    Physiol Rev 81:153-208. 2001
    ..Cascades and cross-talks of small G proteins have also been clarified. In this review, functions of small G proteins and their modes of activation and action are described...
  15. ncbi RHO-GTPases and cancer
    Erik Sahai
    Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Nat Rev Cancer 2:133-42. 2002
    ..A branch of the RAS family--the RHO proteins--is also involved in cancer, but what is the role of these proteins and would they make good therapeutic targets?..
  16. ncbi Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer
    Takao Kamai
    Department of Urology, Dokkyo University School of Medicine, Tochigi 321 0293, Japan
    Clin Cancer Res 9:2632-41. 2003
    ..We investigated the roles of Rho and ROCK in bladder cancer...
  17. pmc The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase
    T Ishizaki
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    EMBO J 15:1885-93. 1996
    ..When co-expressed with RhoA in COS cells, p160 was co-precipitated with the expressed Rho and its kinase activity was activated, indicating that p160 can associate physically and functionally with Rho both in vitro and in vivo...
  18. ncbi The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation
    K Barrett
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown 02129, USA
    Cell 91:905-15. 1997
    ..Together, these results establish a Rho-mediated signaling pathway that is essential for the major morphogenetic events in Drosophila gastrulation...
  19. ncbi Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    Trends Cell Biol 16:522-9. 2006
    ....
  20. ncbi Assembly and mechanosensory function of focal contacts
    B Geiger
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Curr Opin Cell Biol 13:584-92. 2001
    ..The molecular mechanisms underlying these processes are discussed...
  21. pmc The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
    V M Braga
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, WC1E 6BT, London, United Kingdom
    J Cell Biol 137:1421-31. 1997
    ..Our results provide new insights into the role of the small GTPases in the cadherin-dependent cell- cell contact formation and the remodelling of actin filaments in epithelial cells...
  22. ncbi Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion
    Simon Wilkinson
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Nat Cell Biol 7:255-61. 2005
    ..Our data show that a Cdc42-MRCK signal mediates myosin-dependent cell motility and highlight convergence between Rho and Cdc42 signalling...
  23. ncbi Spatial regulation of the exocyst complex by Rho1 GTPase
    W Guo
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8002, USA
    Nat Cell Biol 3:353-60. 2001
    ..These results reveal the action of parallel pathways for the polarized localization of the exocytic machinery, both of which are under the control of Rho1, a master regulator of cell polarity...
  24. pmc Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas
    H Suwa
    Department of Pathology, Graduate School of Medicine, Kyoto University, Japan
    Br J Cancer 77:147-52. 1998
    ..8%) cases, did not affect the expression levels in any of the rho genes. These suggest that elevated expression of the rhoC gene may be involved in the progression of pancreatic carcinoma independent of K-ras gene activation...
  25. ncbi mDia mediates Rho-regulated formation and orientation of stable microtubules
    A F Palazzo
    Department of Anatomy and Cell Biology, Columbia University, New York 10032, USA
    Nat Cell Biol 3:723-9. 2001
    ..Our results show that mDia is sufficient to generate and orient stable microtubules, and indicate that Dia-related formins are part of a conserved pathway that regulates the dynamics of microtubule ends...
  26. ncbi ROCK and Dia have opposing effects on adherens junctions downstream of Rho
    Erik Sahai
    Cancer Research UK Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Nat Cell Biol 4:408-15. 2002
    ..The ability of Dia1 to regulate the actin network is crucial for the localization of adherens junction components to the cell periphery...
  27. ncbi Rho and Rac take center stage
    Keith Burridge
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 116:167-79. 2004
    ..Additionally, we will discuss how there is signaling crosstalk between family members and how various bacterial pathogens have developed strategies to manipulate Rho protein activity so as to enhance their own survival...
  28. pmc A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
    Orion D Weiner
    Department of Cell Biology, Harvard Medical School and Beth Israel Deaconess Medical Center, 240 Longwood Ave C 1, Boston, MA 02115, USA
    Nat Cell Biol 4:509-13. 2002
    ..Emergent properties of positive and negative regulatory links between PtdInsP(3) and Rho family GTPases may constitute a broadly conserved module for the establishment of cell polarity during eukaryotic chemotaxis...
  29. ncbi Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
    N Watanabe
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    Nat Cell Biol 1:136-43. 1999
    ..Thus Rho may induce the formation of different actin structures affected by the balance between mDia1 and ROCK signalling...
  30. ncbi Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo
    J Y Pillé
    Laboratoire de Recherche MERCI, EA 2122, Faculte de Medecine et Pharmacie, 76183 Rouen, France
    Mol Ther 11:267-74. 2005
    ..One may infer from these observations that specific inhibition of the Rho-signaling pathway with siRNAs represents a promising approach for the treatment of aggressive breast cancers...
  31. ncbi Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation
    S Burns
    Molecular Immunology Unit, Institute of Child Health, University College London, United Kingdom
    Blood 98:1142-9. 2001
    ..Formation of podosomes is restricted to cells with an immature phenotype, indicating a specific role for these structures during the early migratory phase. (Blood. 2001;98:1142-1149)..
  32. pmc Rho GTPases have diverse effects on the organization of the actin filament system
    Pontus Aspenstrom
    Ludwig Institute for Cancer Research, Biomedical Center, Box 595, S 751 24 Uppsala, Sweden
    Biochem J 377:327-37. 2004
    ..Collectively, the data obtained in this study to some extent confirm earlier observations, but also allow the identification of previously undetected roles of the different members of the Rho GTPases...
  33. ncbi RAS and RHO GTPases in G1-phase cell-cycle regulation
    Mathew L Coleman
    Abramson Family Cancer Research Institute, BRB II III, 421 Curie Boulevard, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    Nat Rev Mol Cell Biol 5:355-66. 2004
  34. pmc Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation
    L Zeng
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 20:9212-24. 2000
    ..We conclude that Vav3 mediates RPTK signaling and regulates GTPase activity, its native and mutant forms are able to modulate cell morphology, and it has the potential to induce cell transformation...
  35. ncbi Rho GTPases and the regulation of endothelial permeability
    Beata Wojciak-Stothard
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine Branch, 91 Riding House Street, London W1W 7BS, UK
    Vascul Pharmacol 39:187-99. 2002
    ..We also discuss strategies for targeting Rho GTPase signalling in therapies for diseases involving altered endothelial permeability...
  36. ncbi RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo
    Hironori Katoh
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Nature 424:461-4. 2003
    ..We conclude that RhoG activates Rac1 through Elmo and Dock180 to control cell morphology...
  37. ncbi Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity
    Olga Speck
    DCMB Group, Department of Biology, Duke University, Box 91000, Durham, North Carolina 27708, USA
    Nature 421:83-7. 2003
    ..Furthermore, our results show that there is negative feedback between ERM activation and activity of the Rho pathway...
  38. ncbi EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin
    S M Shamah
    Division of Neuroscience, Children s Hospital and the Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Cell 105:233-44. 2001
    ..The association of ephexin with Eph receptors constitutes a molecular link between Eph receptors and the actin cytoskeleton and provides a novel mechanism for achieving highly localized regulation of growth cone motility...
  39. ncbi Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma
    Akiko Horiuchi
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan
    Lab Invest 83:861-70. 2003
    ..These findings suggest that up-regulation of Rho GTPases is important in the tumor progression of ovarian carcinoma and that Rho family proteins could be a molecular target in cancer therapy...
  40. ncbi The role of the Rho GTPases in neuronal development
    Eve Ellen Govek
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 19:1-49. 2005
    ..This review will focus on the role of the Rho GTPases and their associated signaling molecules throughout neuronal development and discuss how perturbations in Rho GTPase signaling may lead to cognitive disorders...
  41. ncbi Integrin signaling to the actin cytoskeleton
    Kris A DeMali
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Curr Opin Cell Biol 15:572-82. 2003
    ..Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion...
  42. ncbi Cell migration: Rho GTPases lead the way
    Myrto Raftopoulou
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, Cancer Research UK Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, UK
    Dev Biol 265:23-32. 2004
    ..Through these diverse functions, Rho GTPases influence many aspects of cell behavior. This review will focus specifically on their role in cell migration...
  43. pmc Identification of filamin as a novel ligand for caveolin-1: evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton
    M Stahlhut
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Mol Biol Cell 11:325-37. 2000
    ..The actin network, therefore, seems to be directly involved in the spatial organization of caveolin-1-associated membrane domains...
  44. pmc Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility
    T Y Kim
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Cancer Metastasis Rev 28:77-83. 2009
    ..We then delineate the characteristics of DLC-1 and other members of its family, and describe how they may have multiple effects on the regulation of cell polarity, actin organization, and cell migration...
  45. ncbi Bacterial toxins that modify the actin cytoskeleton
    Joseph T Barbieri
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee 53226, USA
    Annu Rev Cell Dev Biol 18:315-44. 2002
    ..Each class of toxins gives the bacterial pathogen a selective advantage in modulating host cell resistance to infection...
  46. pmc N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts
    Sophie Charrasse
    Centre de Recherche de Biochimie Macromoleculaire, 34293 Montpellier Cedex, France
    J Cell Biol 158:953-65. 2002
    ..We propose that cell-cell contacts formed via N-cadherin trigger signaling events that promote the commitment to myogenesis through the positive regulation of RhoA and negative regulation of Rac1, Cdc42Hs, and JNK activities...
  47. ncbi Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase
    H Qadota
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
    Science 272:279-81. 1996
    ..Both proteins were localized predominantly at sites of cell wall remodeling. Therefore, it appears that Rho1p is a regulatory subunit of beta(1-->3)glucan synthase...
  48. pmc RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas
    C N Adra
    Harvard Institutes of Medicine, HIM955, Beth Israel Hospital, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 94:4279-84. 1997
    ..We propose that RhoGDI be renamed RhoGDIalpha and GDID4 be renamed RhoGDIbeta. The new GDI should widen the scope of investigation of this important class of regulatory protein...
  49. pmc Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1
    B Philip
    Department of Biochemistry and Molecular Biology, School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 21:271-80. 2001
    ..We demonstrate that Mid2 is not mannosylated in a pmt2 mutant and that this modification is important for signaling by Mid2...
  50. ncbi A RhoGDP dissociation inhibitor spatially regulates growth in root hair cells
    Rachel J Carol
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK
    Nature 438:1013-6. 2005
    ..We propose that the spatial organization of growth in plant cells requires the local RhoGDI-regulated activation of the RHD2/AtrbohC NADPH oxidase...
  51. ncbi Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration
    Aristotelis Astrinidis
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania, PA 19111, USA
    Oncogene 21:8470-6. 2002
    ..Pathways involving Rho activation may have relevance to the clinical manifestations of TSC, including pulmonary lymphangioleiomyomatosis...
  52. ncbi Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
    K Takahashi
    Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565, Japan
    J Biol Chem 272:23371-5. 1997
    ..These results suggest that ERM as well as Rho GDI and the Rho GDP/GTP exchange factor are involved in the activation of the Rho subfamily members, which then regulate reorganization of actin filaments through the ERM system...
  53. pmc Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function
    Rebecca L Berdeaux
    Cancer Research Laboratory, University of California at Berkeley, 94720, USA
    J Cell Biol 166:317-23. 2004
    ..Therefore, Rho is not globally inactivated in Src-transformed fibroblasts, but is necessary for the assembly and function of structures implicated in tumor cell invasion...
  54. ncbi Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and Rho
    A Tashiro
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Cereb Cortex 10:927-38. 2000
    ..We propose a model where Rac promotes spine formation, while Rho prevents it. We conclude that the small GTPases provide antagonistic control mechanisms of spine maintenance in pyramidal neurons...
  55. pmc Integrins control motile strategy through a Rho-cofilin pathway
    Erik H J Danen
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Cell Biol 169:515-26. 2005
    ..Thus, alterations in integrin expression profiles allow cells to modulate several critical aspects of the motile machinery through Rho GTPases...
  56. pmc Growth-regulated expression of rhoG, a new member of the ras homolog gene family
    S Vincent
    URA CNRS 1191 Génétique Moléculaire, Universite Montpellier II Sciences et Techniques du Languedoc, France
    Mol Cell Biol 12:3138-48. 1992
    ..rhoG mRNA expression is observed in a wide variety of human organs but reaches a particularly high level in lung and placental tissues...
  57. ncbi Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse
    Mustafa Sahin
    Neurobiology Program, Children s Hospital, Boston, Massachusetts 02115, USA
    Neuron 46:191-204. 2005
    ..These findings reveal that ephexin1 plays a role in axon guidance and is regulated by a switch mechanism that is specifically tailored to control Eph-mediated growth cone collapse...
  58. pmc Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae
    Mariko Sekiya-Kawasaki
    Department of Integrated Biosciences, Graduate School of Frontier Science, University of Tokyo, Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
    Genetics 162:663-76. 2002
    ..We have also found that MID2 acts positively on Pkc1p without affecting 1,3-beta-glucan synthesis. These results suggest that distinct networks regulate the two effector proteins of Rho1p, Fks1p and Pkc1p...
  59. ncbi Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling
    M Kanzaki
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 276:42436-44. 2001
    ..In addition, cortical F-actin does not function in a static manner (e.g. barrier or scaffold), but insulin-stimulated dynamic cortical actin remodeling is necessary for the GLUT4 translocation process...
  60. pmc Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion
    Rubén A Bartolomé
    Department of Immunology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Cancer Res 66:248-58. 2006
    ..Together, these data indicate that activation of Jak/Vav/Rho GTPase pathway by CXCL12 is a key signaling event for MT1-MMP/MMP-2-dependent melanoma cell invasion...
  61. pmc RhoE function is regulated by ROCK I-mediated phosphorylation
    Kirsi Riento
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
    EMBO J 24:1170-80. 2005
    ..This is the first demonstration of an endogenous Rho family member being phosphorylated in vivo and indicates that phosphorylation is an important mechanism to control the stability and function of this GTPase-deficient Rho protein...
  62. pmc Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2
    T Sumi
    Division of Biochemistry, Department of Oncology, Biomedical Research Center, Osaka University Medical School, Suita, Japan
    J Cell Biol 147:1519-32. 1999
    ....
  63. ncbi A Rho GTPase signaling pathway is used reiteratively in epithelial folding and potentially selects the outcome of Rho activation
    Kelly K Nikolaidou
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, United Kingdom
    Curr Biol 14:1822-6. 2004
    ..Fog and Cta also play a role in the morphogenetic events requiring DRhoGEF2, suggesting the existence of a conserved signaling pathway in which Fog, Cta, and DRhoGEF2 locally activate Myosin for epithelial invagination and folding...
  64. ncbi Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis
    Marcos Vidal
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA
    Dev Cell 10:33-44. 2006
    ....
  65. ncbi Rho localization in cells and tissues
    Shigenobu Yonemura
    Laboratory for Cellular Morphogenesis, RIKEN Center for Developmental Biology, Chuo, Kobe, Hyogo 650 0047, Japan
    Exp Cell Res 295:300-14. 2004
    ..In mouse tissues, Rho localization differed depending on cell type, probably reflecting the functional differences of each cell type...
  66. ncbi Rho-family GTPases: it's not only Rac and Rho (and I like it)
    Krister Wennerberg
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    J Cell Sci 117:1301-12. 2004
    ..Newer members of the family possess additional sequence elements beyond the GTPase domain, which suggests they exhibit yet other mechanisms of regulation...
  67. pmc Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway
    Lingzhi Fan
    St Michael s Hospital Research Institute, Toronto, ON, Canada M5B 1W8
    Mol Biol Cell 18:1083-97. 2007
    ..These studies define a new mechanism whereby cell contacts regulate epithelial-myofibroblast transition via Rho-ROK-phospho-MLC-dependent nuclear accumulation of MRTF...
  68. ncbi GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons
    Andrew F Macaskill
    Department of Neuroscience, Physiology and Pharmacology, University College London, UK
    Mol Cell Neurosci 40:301-12. 2009
    ..These data suggest that Miro1 and the kinesin adaptor Grif-1 play an important role in regulating mitochondrial transport in neurons...
  69. pmc The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarity
    J E Adamo
    Department of Cell Biology, Cell Biology, and Genetics, Weill Medical College of Cornell University, New York, New York 10021, USA
    Mol Biol Cell 10:4121-33. 1999
    ..These data suggest that Rho3 acts as a key regulator of cell polarity and exocytosis, coordinating several distinct events for delivery of proteins to specific sites on the cell surface...
  70. ncbi The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
    A Schmidt
    Department of Biochemistry, Biozentrum, University of Basel, Switzerland
    Cell 88:531-42. 1997
    ..Thus, TOR2 signals to the actin cytoskeleton through a GTPase switch composed of RHO1, RHO2, ROM2, and SAC7. TOR2 activates this switch via ROM2, possibly via the ROM2 PH domain...
  71. ncbi Diverse roles of Rho family GTPases in neuronal development, survival, and death
    Daniel A Linseman
    Veterans Affairs Medical Center, Denver, CO 80220, USA
    Front Biosci 13:657-76. 2008
    ....
  72. pmc Mechanically induced osteogenic differentiation--the role of RhoA, ROCKII and cytoskeletal dynamics
    Emily J Arnsdorf
    Bone and Joint R and D Center, VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Cell Sci 122:546-53. 2009
    ..Finally, we show RhoA activation and actin tension are negative regulators of both adipogenic and chondrogenic differentiation. However, an intact, dynamic actin cytoskeleton under tension is necessary for flow-induced gene expression...
  73. ncbi Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cells
    Marylise Hebert
    Institut National de la Santé et de la Recherche Médicale U749, Faculte de Pharmacie, Chatenay Malabry, France
    J Immunol 181:5963-73. 2008
    ..Thus, phosphorylation of E/M by ROCK is involved in the early steps of apoptotic signaling following Fas triggering and regulates apoptosis induction...
  74. ncbi Genomic analysis of metastasis reveals an essential role for RhoC
    E A Clark
    Howard Hughes Medical Institute, Centre for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 406:532-5. 2000
    ..The genomic approach allows us to identify families of genes involved in a process, not just single genes, and can indicate which molecular and cellular events might be important in complex biological processes such as metastasis...
  75. pmc Intracellular localization of the P21rho proteins
    P Adamson
    Section of Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    J Cell Biol 119:617-27. 1992
    ....
  76. ncbi Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis
    Sergio Simoes
    Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Portugal
    Development 133:4257-67. 2006
    ....
  77. ncbi Rho GTPases are over-expressed in human tumors
    G Fritz
    Institute of Toxicology, Division of Applied Toxicology, University of Mainz, Germany
    Int J Cancer 81:682-7. 1999
    ..Overall, increase in the amount of Rho GTPases, in particular RhoA, appears to be a frequent event in different types of human tumors. This supports the view that Rho GTPases are involved in human carcinogenesis...
  78. ncbi Mechanism and function of formins in the control of actin assembly
    Bruce L Goode
    Department of Biology and Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, Massachusetts 02454, USA
    Annu Rev Biochem 76:593-627. 2007
    ..Other classes of formins lack the autoinhibitory and/or Rho-binding domains and thus are likely to be controlled by alternative mechanisms...
  79. ncbi Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates
    D Yamazaki
    Division of Membrane Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Hyogo, Japan
    Oncogene 28:1570-83. 2009
    ..Hence, we could conclude that Rac1 and RhoA signaling simultaneously regulate cell invasion in 3D matrices...
  80. ncbi Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins
    Nahum Meller
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037, USA
    Nat Cell Biol 4:639-47. 2002
    ..CZH2-containing proteins constitute a new superfamily that includes the so-called 'CDM' proteins that bind to and activate Rac. Together, the results suggest that CZH2 is a new GEF domain for the Rho family of proteins...
  81. pmc Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules
    Takeshi Nakamura
    Department of Molecular Genetics, National Institute for Longevity Sciences, Program of Protecting the Brain, CREST, JST, Oobu, Aichi 474 8522, Japan
    Mol Cell Biol 22:8721-34. 2002
    ..These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases...
  82. ncbi ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells
    S Etienne
    Centre Nationale de la Recherche Scientifique, Unité Propre de Recherche 0415, Institut Cochin de Genetique Moleculaire, Paris, France
    J Immunol 161:5755-61. 1998
    ....
  83. pmc Direct cadherin-activated cell signaling: a view from the plasma membrane
    Alpha S Yap
    School for Biomedical Science and Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Australia 4072
    J Cell Biol 160:11-6. 2003
    ..Recent developments indicate that classical cadherins are adhesion-activated signaling receptors. In particular, early-immediate Rac signaling is emerging as a mechanism to coordinate cadherin-actin integration at the plasma membrane...
  84. ncbi Rho1 directs formin-mediated actin ring assembly during budding yeast cytokinesis
    Nicola Tolliday
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 12:1864-70. 2002
    ....
  85. ncbi Dynamic analysis of dorsal closure in Drosophila: from genetics to cell biology
    Antonio Jacinto
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 6, 2780 156, Oeiras, Portugal
    Dev Cell 3:9-19. 2002
    ....
  86. ncbi Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion
    William T Arthur
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Biol Res 35:239-46. 2002
    ....
  87. pmc Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis
    Claire E Walters
    Department of Cell Biology, Institute of Ophthalmology, and Neuroinflammation Group, University College London, London, United Kingdom
    J Immunol 168:4087-94. 2002
    ..These studies demonstrate, for the first time, the potential for pharmacologically targeting CNS EC signaling responses, and particularly endothelial Rho proteins, as a means of attenuating leukocyte recruitment to the CNS...
  88. pmc Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation
    R Foster
    Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Mol Cell Biol 16:2689-99. 1996
    ..Thus, two unusual structural features of this novel Rho protein suggest a striking evolutionary divergence from the Rho family of GTPases...
  89. ncbi Dock4 is regulated by RhoG and promotes Rac-dependent cell migration
    Kiyo Hiramoto
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Exp Cell Res 312:4205-16. 2006
    ..Taken together, these results suggest that Dock4 plays an important role in the regulation of cell migration through activation of Rac1, and that RhoG is a key upstream regulator for Dock4...
  90. ncbi Rac 'n Rho: the music that shapes a developing embryo
    J Settleman
    Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Dev Cell 1:321-31. 2001
    ..The Drosophila genetic system has proved particularly useful in establishing the in vivo functions of several of the Rho GTPases and their associated signaling pathway components during development...
  91. pmc Regulation of cytokinesis by Rho GTPase flux
    Ann L Miller
    Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Nat Cell Biol 11:71-7. 2009
    ....
  92. ncbi Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation
    T Kitamura
    Division of Cellular Therapy, Advanced Clinical Research Center, and The Institute of Medical Science, University of Tokyo, Japan
    Cell Struct Funct 26:645-51. 2001
    ..These results indicate that MgcRacGAP regulates cytokinesis and cellular differentiation as a regulator of Rho family of GTPase and suggest that this process is controlled by some serine/threonine kinases...
  93. pmc Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation
    James P Madigan
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochem J 424:153-61. 2009
    ..These results identify an additional mechanism of regulation and provide clarification of how Rnd3 modulates Rho signalling to alter cytoskeletal organization...
  94. pmc SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis
    Shawn M Ellerbroek
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Biol Cell 15:3309-19. 2004
    ..Together, this work establishes SGEF as a RhoG exchange factor and provides evidence that both SGEF and RhoG regulate membrane dynamics in promotion of macropinocytosis...
  95. ncbi FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
    Yasutaka Ohta
    Hematology Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 8:803-14. 2006
    ..FilGAP is, therefore, a mediator of the well-established antagonism of Rac by RhoA that suppresses leading edge protrusion and promotes cell retraction to achieve cellular polarity...
  96. ncbi Rho GTPases: functions and association with cancer
    Saskia I J Ellenbroek
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Clin Exp Metastasis 24:657-72. 2007
    ..The main focus of this review will be the diversity of functions of Rho GTPases and the effects of aberrant Rho GTPase signalling in various aspects of cancer...
  97. ncbi Cell signaling and cancer
    G Steven Martin
    Department of Molecular and Cell Biology, University of California at Berkeley, 16 Barker Hall 3204, Berkeley, CA 94720, USA
    Cancer Cell 4:167-74. 2003
    ..The nature of these signaling pathways and their roles in tumorigenesis were the subject of a recent Beatson International Cancer Conference...
  98. ncbi The role of Rho GTPases and associated kinases in regulating neurite outgrowth
    Margareta Nikolic
    Molecular and Developmental Neurobiology MRC Centre, New Hunt s House, King s College London, London SE1 1UL, UK
    Int J Biochem Cell Biol 34:731-45. 2002
    ..This review discusses individual kinases that are regulated by three members of the Rho GTPases, Rac, Rho and Cdc42 and their function during neurite outgrowth and remodelling...
  99. pmc B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization
    R Matthew Klein
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    Mol Biol Cell 19:498-508. 2008
    ..Together, our results identify Rnd3 as a regulator of cross talk between the RAF/MEK/ERK and Rho/ROCK signaling pathways, and a key contributor to oncogene-mediated reorganization of the actin cytoskeleton and focal adhesions...
  100. ncbi Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho
    M H Driessens
    MRC Laboratory for Molecular Cell Biology, Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, United Kingdom
    Curr Biol 11:339-44. 2001
    ..Our findings that plexin-B signaling to the cytoskeleton is both Rac and Rho dependent form a starting point for unraveling the mechanism by which semaphorins and plexins control axon guidance and cell migration...
  101. ncbi RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism
    Nao Yamaki
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    Exp Cell Res 313:2821-32. 2007
    ..Taken together, these results suggest that RhoG protects cells from apoptosis caused by the loss of anchorage through a PI3K-dependent mechanism, independent of its activation of Rac1...

Research Grants62

  1. GF REGULATION/GASTRIC MUCOSAL PARACELLULAR PERMEABILITY
    ANDREW SOLL; Fiscal Year: 2003
    ..g., phosphatidylinositol-3 kinase or the Rho GTP binding proteins) will be assessed by use of specific inhibitors and activators...
  2. STRUCTURE AND REGULATION OF CDC42HS
    Robert Oswald; Fiscal Year: 2001
    ..The rho GTP binding proteins are a subfamily of the ras superfamily of GTP binding proteins...
  3. Role of Rho Kinase in Aqueous Humor Outflow Pathway
    P Rao; Fiscal Year: 2004
    ..Identification of specific signaling mechanisms regulating function of outflow pathway tissues could enable the design of target-specific approaches to the treatment of glaucoma. ..
  4. Regulation and Functin of the p190 RhoGAPs
    Jeffrey Settleman; Fiscal Year: 2006
    ..This is an important step toward establishing an accurate picture of the regulatory mechanisms for small GTPases in vivo, and the nature of their dysregulation in human cancers. ..
  5. RhoH GTPase in blood cell and cancer development
    Yi Gu; Fiscal Year: 2006
    ..Given the lineage-restricted expression of RhoH such an observation could have important therapeutic implication. ..
  6. Gefitinib-sensitive EGF receptor mutants in lung cancer
    Jeffrey Settleman; Fiscal Year: 2009
    ....
  7. Role of Vav family proteins in cell signaling and cancer
    XOSE BUSTELO; Fiscal Year: 2009
    ..abstract_text> ..
  8. Specific Biochemical Inactivation of Oncogenic Ras
    Jeffrey Settleman; Fiscal Year: 2008
    ..Together, the proposed studies are expected to lead to the eventual development of a novel therapeutic approach for achieving specific targeting of human tumors that harbor oncogenic mutant forms of Ras. ..
  9. RHO GTPASE SIGNALING IN EMBRYO MORPHOGENESIS
    Jeffrey Settleman; Fiscal Year: 2003
    ..abstract_text> ..
  10. FASEB Summer Research Conference on Small G-Proteins
    Jeffrey Settleman; Fiscal Year: 2004
    ..The conference will cover the biochemical, structural, and functional aspects of the various small GTPases and their regulators and targets. ..
  11. Rho GtPase and Cell Cycle Regulation in Breast Cancer
    Catherine Welsh; Fiscal Year: 2005
    ..Welsh's progression to the status of independent investigator. ..
  12. Role of LIBC in Inflammatory Breast Cancer Phenotype
    Celina Kleer; Fiscal Year: 2007
    ..Also, understanding the role of WISP3 will shed light on the mechanisms of cancer development in general and serve as a model for other related CCN genes involved in carcinogenesis. ..
  13. The type III secretion effector protein interactome
    JORGE GALAN; Fiscal Year: 2008
    ..It is expected that these studies will provide an extremely useful resource for the understanding of the pathogenesis of many important bacterial diseases. [unreadable] [unreadable] [unreadable]..
  14. REGULATORY MECHANISMS OF KALIRIN'S GEF1 DOMAIN
    Martin Schiller; Fiscal Year: 2006
    ..Understanding the mechanism by which the GEF domain of kalirin is controlled will provide a basis for future studies to determine the mechanisms by which kalirin controls neuronal morphology. ..
  15. REGULATION OF SUPEROXIDE PRODUCTION BY HUMAN NEUTROPHILS
    Jeffrey Friedman; Fiscal Year: 2007
    ..These studies may ultimately lead to new pharmacological methods for controlling oxygen radical-mediated tissue damage as well as an improved understanding of the pathophysiology of CGD. ..
  16. Hormonal Regulation of Glycogen Synthesis
    Alan R Saltiel; Fiscal Year: 2010
    ....
  17. Mechanisms of Integrin-Microtubule Cross-talk
    Gregg G Gundersen; Fiscal Year: 2010
    ....
  18. PREVENTION OF MAMMARY CANCER IN HER-2NEU TRANSGENIC MICE
    Sofia Merajver; Fiscal Year: 2007
    ..Understand whether TM regulates uPAR expression and erk signaling in her2 and wnt transgenic tumors. ..
  19. REGULATION OF NEUTROPHIL RECEPTOR G PROTEIN INTERACTIONS
    Gary Bokoch; Fiscal Year: 2009
    ..Spatio-temporal evaluation of Rho activation will be related to Rac2 activity, as well as specific aspects of a) chemoattractant receptor signaling, b) motile behavior, and c) actin-myosin cytoskeletal dynamics. ..
  20. Molecular Mechanisms of Salmonella typhi Pathogenicity
    Jorge E Galan; Fiscal Year: 2010
    ..abstract_text> ..
  21. Role of Prostaglandins & Phospholipase A in melanocytes
    Glynis Scott; Fiscal Year: 2009
    ..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
  22. HTS For Inhibitors of NADPH Oxidase 1 (Nox1)
    Gary Bokoch; Fiscal Year: 2008
    ..Such inhibitors will be useful to investigate Nox1 biology, and as potential therapeutic agents in inflammatory diseases and cancer. [unreadable] [unreadable] [unreadable]..
  23. Identification of RhoGEFs as novel therapeutic targets for malignant glioma
    Marc Symons; Fiscal Year: 2008
    ..We also expect that we will obtain significant clinical information that will aid in the validation of these invasion genes. [unreadable] [unreadable] [unreadable] [unreadable]..
  24. Reactive Oxygen Species in Anti-Viral Airway Host Defense
    Jeffrey Friedman; Fiscal Year: 2008
    ..Our studies will show if oxidases are a promising target for therapeutic drug development. [unreadable] [unreadable] [unreadable] [unreadable]..
  25. Role of Synaptojanin 2 in Tumor Cell Invasion
    Marc Symons; Fiscal Year: 2009
    ..The molecular analysis of the functions of SJ2 in the formation of lamellipodia and invadopodia and tumor cell migration and invasion will significantly expand our current understanding of the role of Rac1 in malignant transformation. ..
  26. HOST CELL SIGNALING PATHWAYS INDUCED BY SALMONELLA
    JORGE GALAN; Fiscal Year: 2002
    ..typhi. ..
  27. 2004 Molecular & Cellular Neurobiology Gordon Conference
    Liqun Luo; Fiscal Year: 2004
    ..Majority of which be used to support conference fees and/or travel of students and postdocs from US, especially minority and women participants to increase their number. ..
  28. CONTROL OF PHAGOCYTE NADPH OXIDASE BY CYTOSOLIC PROTEINS
    Gary Bokoch; Fiscal Year: 2005
    ....
  29. MECHANISMS OF NEURONAL REORGANIZATION
    Liqun Luo; Fiscal Year: 2004
    ..These mechanisms may also be used for experience-dependent reshaping of neuronal connections, and may be misregulated during aging and neurodegenerative diseases to cause degeneration of neuronal processes. ..
  30. SALMONELLA TYPE 3 SECRETION SYSTEM FOR ANTIGEN DELIVERY
    JORGE GALAN; Fiscal Year: 2004
    ..This will significantly broaden the utility of avirulent strains of Salmonella as platforms for the development of polyvalent vaccines. ..
  31. REGULATION OF HUMAN PHAGOCYTE FUNCTION BY RAC PROTEINS
    Ulla Knaus; Fiscal Year: 2006
    ..These studies will yield novel insights into the overall control of oxidant formation by innate immune cells. ..
  32. Total Internal Reflection Fluorescence Microscope
    GREGG GUNDERSEN; Fiscal Year: 2003
    ....
  33. MOLECULAR MECHANISMS OF NEURONAL MORPHOGENESIS
    Liqun Luo; Fiscal Year: 2004
    ....
  34. Mechanochemical regulation of endothelial permeability
    Konstantin Birukov; Fiscal Year: 2007
    ....
  35. Predicting common protein mechanisms by the light of evolution
    ANDREW NEUWALD; Fiscal Year: 2009
    ..And (v) propose molecular mechanisms based on these analyses. ..
  36. Bone Loss and Its Prevention in HIV Patients
    F Ross; Fiscal Year: 2006
    ..The mechanism by which Ritonavir, blunts RANKL-induced signaling, in OCs and their precursors; 3. If administration of Ritonavir, or GST-RANKL, will prevent and/or rescue Indinavir-induced osteoporosis. ..
  37. Vessel Remodeling During Ductus Arteriosus Closure
    Ronald I Clyman; Fiscal Year: 2010
    ..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..
  38. G PROTEIN REGULATION OF THE NEUTROPHIL NADPH OXIDASE
    Celine DerMardirossian; Fiscal Year: 2010
    ..We will study how a newly identified group of Src target proteins act to organize Nox assembly and localized activity. Understanding Nox regulation will have important implications for disease therapy. ..
  39. Integrating CAM into conventional medicine
    Joan Fox; Fiscal Year: 2002
    ..We anticipate that these studies will identify a sustainable, reproducible strategy for integrating CAM research into conventional practice and should provide insight into features that favor successful integration. ..
  40. Regulation of CNS Angiogenesis By GPR124
    Calvin Kuo; Fiscal Year: 2009
    ..Finally, conditional approaches to GPR124 inactivation will be pursued using adenoviral and conditional knockout strategies, to facilitate the eventual study of GPR124 function in fully adult organisms. ..
  41. The Exocyst in Synthesis, Cystogenesis and Tubulogenesis
    JOSHUA LIPSCHUTZ; Fiscal Year: 2009
    ..abstract_text> ..
  42. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2005
    ..They will also provide new molecular tools that could prove to be valuable adjuncts for cancer chemotherapy. ..
  43. Molecular Mechanisms of Portal Hypertension
    Vijay Shah; Fiscal Year: 2007
    ..abstract_text> ..
  44. RANK Ligand is a Bone Anabolic Agent
    Steven Teitelbaum; Fiscal Year: 2006
    ..abstract_text> ..
  45. AIDS MALIGNANCY CONSORTIUM
    Joseph Sparano; Fiscal Year: 2005
    ..abstract_text> ..
  46. Major Challenges in Clinical Medicine: An Overview for *
    Rudolph Juliano; Fiscal Year: 2006
    ..As part of this component the trainee, with the mentor's guidance, will prepare the Abstract and Specific Aims of an NIH-type grant proposal dealing with a translational research topic. ..
  47. The Role of Tuberin in Smooth Muscle Cell Proliferation
    Geraldine Finlay; Fiscal Year: 2007
    ..abstract_text> ..
  48. Utilizing Saliva to Measure Bone Turnover
    Sreenivas Koka; Fiscal Year: 2007
    ..We anticipate that our results will identify how salivary biomarkers can be used to assess the osseo-status of patients with, or at risk for, osteoporosis. [unreadable] [unreadable] [unreadable] [unreadable]..
  49. PROTEOMICS OF REGULATED EXOCYTOSIS IN OSTEOCLASTS
    F Ross; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  50. Rho-Dependent COX-2 Expression in Intestinal Cells
    Lee Slice; Fiscal Year: 2007
    ..3) Define the role of Rho and of Protein Kinases acting upstream and downstream of Rho in COX-2 expression in intestinal epithelial cells. 4) Characterize COX-2 promoter elements that are responsive to Rho. ..
  51. Gordon Conference "Motile and Contractile Systems" 2005
    Vladimir Gelfand; Fiscal Year: 2005
    ..Conferees who do not make oral contributions will be encouraged to present their recent work in a poster format. ..
  52. Cytokine regulation of glial reactivity
    Gareth John; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  53. Molecular pathogenesis of P. aeruginosa in CF
    Joseph Barbieri; Fiscal Year: 2005
    ..aeruginosa infections, as well as, provide insight towards the identification of vaccine candidates to delay or prevent infection. ..
  54. Effects of Reiki on Physiological Consequences of Acute Stress
    Joan Fox; Fiscal Year: 2007
    ..Should Reiki decrease stress pathways or reduce physiological responses to stressful situations, it could be a powerful adjunct to traditional medicine and have enormous health and economic impact. ..
  55. Dbl-like Regulators of Small GTP-binding Proteins
    Yi Zheng; Fiscal Year: 2008
    ..The results may also provide valuable pharmacological reagents for the intervention of the GEF-mediated signaling. ..
  56. Function of Cortactin, a Src Target
    J Parsons; Fiscal Year: 2005
    ..Such mice, bearing a mutated form of Cortactin will allow one to directly test the role of Cortactin in mediating specific cellular functions in a cell type specific fashion. ..
  57. Cytoskeletal Regulation of Outer Hair Cell Motility
    Federico Kalinec; Fiscal Year: 2007
    ..abstract_text> ..
  58. Mechanism of Actions of Multitasking of Statins in AD
    Inderjit Singh; Fiscal Year: 2006
    ..abstract_text> ..
  59. G protein signal integration by multifunctional proteins
    T Harden; Fiscal Year: 2006
    ..abstract_text> ..