rap gtp binding proteins

Summary

Summary: A family of MONOMERIC GTP-BINDING PROTEINS that are related to RAS PROTEINS.This enzyme was formerly listed as EC 3.6.1.47.

Top Publications

  1. ncbi Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
    J de Rooij
    Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands
    Nature 396:474-7. 1998
  2. pmc Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins
    Yu Li
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 179:8322-31. 2007
  3. ncbi The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity
    Jens C Schwamborn
    Abteilung Molekularbiologie, Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat Munster, Germany
    Nat Neurosci 7:923-9. 2004
  4. pmc A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
    H Kawasaki
    Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 95:13278-83. 1998
  5. pmc Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G
    T Gotoh
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Mol Cell Biol 15:6746-53. 1995
  6. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005
  7. ncbi Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product
    H Kurachi
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606, Japan
    J Biol Chem 272:28081-8. 1997
  8. ncbi The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands
    Kevin B L Lin
    Department of Microbiology and Immunology, I3 and CELL Research Groups, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Immunity 28:75-87. 2008
  9. ncbi Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively
    M F Rousseau-Merck
    INSERM U 301 et GRECO 140 CNRS, Hopital Saint Louis, Paris, France
    Cytogenet Cell Genet 53:2-4. 1990
  10. ncbi Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1
    B Rubinfeld
    Cetus Corporation, Emeryville, California 94608
    Cell 65:1033-42. 1991

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Detail Information

Publications138 found, 100 shown here

  1. ncbi Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
    J de Rooij
    Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands
    Nature 396:474-7. 1998
    ..cAMP strongly induces the GEF activity of Epac towards Rap1 both in vivo and in vitro. We conclude that Epac is a GEF for Rap1 that is regulated directly by cAMP and that Epac is a new target protein for cAMP...
  2. pmc Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins
    Yu Li
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 179:8322-31. 2007
    ....
  3. ncbi The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity
    Jens C Schwamborn
    Abteilung Molekularbiologie, Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat Munster, Germany
    Nat Neurosci 7:923-9. 2004
    ..Using GTPase mutants and RNA interference, we found that Rap1B is necessary and sufficient to initiate the development of axons upstream of Cdc42 and the Par complex...
  4. pmc A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
    H Kawasaki
    Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 95:13278-83. 1998
    ..The expression of CalDAG-GEFI and CalDAG-GEFII in hematopoietic organs suggests that such control may have broad significance in Ras/Rap regulation of normal and malignant states...
  5. pmc Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G
    T Gotoh
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Mol Cell Biol 15:6746-53. 1995
    ..Furthermore, expression of C3G with a membrane localization signal in a v-Ki-ras transformant, DT, induced a reversion of the cells to the flat form, possibly through the activation of endogenous Rap1...
  6. pmc Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005
    ..These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target...
  7. ncbi Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product
    H Kurachi
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606, Japan
    J Biol Chem 272:28081-8. 1997
    ..These results suggested that products of SPA-1 and rap1GAP genes, albeit comparable GAP activity for Rap1 and Rap2, functioned in the distinct contexts depending on cell types and/or states...
  8. ncbi The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands
    Kevin B L Lin
    Department of Microbiology and Immunology, I3 and CELL Research Groups, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Immunity 28:75-87. 2008
    ..Thus by controlling B cell morphology and cytoskeletal organization, Rap might play a key role in the activation of B cells by particulate and cell-associated antigens...
  9. ncbi Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively
    M F Rousseau-Merck
    INSERM U 301 et GRECO 140 CNRS, Hopital Saint Louis, Paris, France
    Cytogenet Cell Genet 53:2-4. 1990
    ..The three genes RAP1A, RAP1B, and RAP2 have been assigned to chromosome bands 1p12----p13, 12q14, and 13q34, respectively...
  10. ncbi Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1
    B Rubinfeld
    Cetus Corporation, Emeryville, California 94608
    Cell 65:1033-42. 1991
    ....
  11. ncbi Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity
    Haiyan Chu
    Laboratory of Molecular Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 181:3373-83. 2008
    ..However, absence of Rap1b did not affect splenic B cell proliferation, BCR-mediated activation of Erk1/2, p38 MAPKs, and AKT. Thus, Rap1b is crucial for early B cell development, MZ B cell homeostasis and T-dependent humoral immunity...
  12. pmc Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3
    Matthias B Stope
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Mol Cell Biol 24:4664-76. 2004
    ..Collectively, these data suggest that the EGF receptor triggers activation of Rap2B via PLC-gamma1 activation and tyrosine phosphorylation of RasGRP3 by c-Src, finally resulting in stimulation of PLC-epsilon...
  13. ncbi A novel cAMP-dependent pathway activates neuronal integrin function in retinal neurons
    Jonathan K Ivins
    Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Neurosci 24:1212-6. 2004
    ..Surprisingly, these effects of cAMP are independent of protein kinase A and the EPAC (exchange protein directly activated by cAMP)/Rap pathway and suggest the existence of a novel cAMP-dependent mechanism...
  14. ncbi Inhibition of phospholipase C-epsilon by Gi-coupled receptors
    Frank vom Dorp
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Cell Signal 16:921-8. 2004
    ..In summary, our data indicate that Gi-coupled receptors can inhibit PLC-epsilon, most likely by suppressing formation of cyclic AMP required for Epac-mediated Rap2B activation...
  15. ncbi Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1
    S N Peterson
    Division of Cell Biology, Glaxo Wellcome Inc, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 271:29903-8. 1996
    ..We conclude that RGL2 may be an effector for Ras and/or Rap proteins...
  16. pmc Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis
    Y Ohba
    Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    EMBO J 20:3333-41. 2001
    ..In conclusion, C3G-dependent activation of Rap1 is required for adhesion and spreading of embryonic fibroblasts and for the early embryogenesis of the mouse...
  17. pmc Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization
    Andrea Farina
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2753, USA
    Mol Cell Biol 24:9059-69. 2004
    ..This work reveals a novel link between Brd4 and a GTPase-dependent mitogenic signaling pathway...
  18. ncbi Activation of the small GTPase Rap2B in agonist-stimulated human platelets
    F Greco
    Center of Excellence for Applied Biology, Department of Biochemistry, University of Pavia, Pavia, Italy
    J Thromb Haemost 2:2223-30. 2004
    ..These results demonstrate that the small GTPase Rap2B is involved in platelet activation, and outline some important differences between the regulation of highly related GTPases Rap2B and Rap1B in human platelets...
  19. ncbi Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
    J de Rooij
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Biol Chem 275:20829-36. 2000
    ..Epac1 becomes activated by a release of this inhibition when cAMP is bound...
  20. ncbi The lutropin/choriogonadotropin receptor-induced phosphorylation of the extracellular signal-regulated kinases in leydig cells is mediated by a protein kinase a-dependent activation of ras
    Takashi Hirakawa
    Department of Pharmacology, University of Iowa, Iowa City, Iowa 52242 1109, USA
    Mol Endocrinol 17:2189-200. 2003
    ..Collectively, our results show that the hLHR-induced phosphorylation of ERK1/2 in Leydig cells is mediated by a protein kinase A-dependent activation of Ras...
  21. ncbi Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation
    Sherri L Christian
    Department of Microbiology and Immunology, University of British Columbia, 6174 University Boulevard, Vancouver, BC V6T 1Z3, Canada
    J Biol Chem 278:41756-67. 2003
    ....
  22. ncbi The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): potential role for Rap2 in promoting B cell migration
    Sarah J McLeod
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 169:1365-71. 2002
    ..Conversely, expressing a constitutively active form of Rap2 increased SDF-1-induced B cell migration. Thus, the Rap GTPases control cellular processes that are important for B cells to migrate toward SDF-1...
  23. pmc Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae
    S Colombo
    Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Flanders, Belgium
    EMBO J 17:3326-41. 1998
    ..Interaction of Ras2(val19) with adenylate cyclase apparently prevents its activation by both agonists...
  24. pmc Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes
    S Okada
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, IA 52242, USA
    EMBO J 17:2554-65. 1998
    ..Together, these data demonstrate that insulin treatment results in the de-repression of Rap1 inhibitory function on the Raf1 kinase concomitant with Ras activation and stimulation of the downstream Raf1/MEK/ERK cascade...
  25. ncbi Cyclic AMP-independent involvement of Rap1/B-Raf in the angiotensin II AT2 receptor signaling pathway in NG108-15 cells
    Louis Gendron
    Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 278:3606-14. 2003
    ..Therefore, the AT(2) receptor of Ang II activates the signaling modules of Rap1/B-Raf and p42/p44(mapk) via a cAMP-independent pathway to induce morphological differentiation of NG108-15 cells...
  26. pmc On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b
    Fernando Ribeiro-Neto
    Department of Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 99:5418-23. 2002
    ..Here we report that cAMP-dependent hormonal stimulation of DNA synthesis requires Rap1b in a manner dependent on its phosphorylation by protein kinase A...
  27. ncbi Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B
    Sandrine Evellin
    Institut fur Pharmakologie, Universitatsklinikum Essen, D 45122 Essen, Germany
    J Biol Chem 277:16805-13. 2002
    ....
  28. pmc Activation of the Ras superfamily of small GTPases. Workshop on exchange factors
    Yi Zheng
    Division of Experimental Hematology, Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    EMBO Rep 4:463-8. 2003
  29. ncbi Src-CrkII-C3G-dependent activation of Rap1 switches growth hormone-stimulated p44/42 MAP kinase and JNK/SAPK activities
    Ling Ling
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    J Biol Chem 278:27301-11. 2003
    ..In addition, we demonstrated that C3G-Rap1 mediated CrkII enhancement of GH-stimulated JNK/SAPK activity. We have therefore identified a linear JAK2-independent pathway switching GH-stimulated p44/42 MAP kinase and JNK/SAPK activities...
  30. ncbi Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase
    Noriko Machida
    Division of Cell Biology, Graduate School of Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    J Biol Chem 279:15711-4. 2004
    ..Furthermore, Rap2 enhanced MAP4K4-induced activation of JNK. These results suggest that MAP4K4 is a putative effector of Rap2 mediating the activation of JNK by Rap2...
  31. ncbi PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector
    Bat Erdene Myagmar
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Biochem Biophys Res Commun 329:1046-52. 2005
    ..Rap2 suppressed this in vivo action of PARG1 but not that of the mutant PARG1. These results suggest that PARG1 is a putative specific effector of Rap2 to regulate Rho...
  32. ncbi Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins
    Simona Paganini
    Center of Excellence for Applied Biology, Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    Biochimie 88:285-95. 2006
    ..This new protein may therefore contribute to the still poorly clarified cellular events regulated by this subfamily of GTP-binding proteins...
  33. pmc Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes
    Rasmus Koefoed Petersen
    BioLigands, International Science Park Odense, DK 5230 Odense M, Denmark
    Mol Cell Biol 28:3804-16. 2008
    ....
  34. ncbi Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP
    Rahul Das
    Department of Chemistry, Biochemistry, and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4M1, Canada
    J Biol Chem 283:19691-703. 2008
    ....
  35. ncbi cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b
    Liguang Lou
    Department of Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 277:32799-806. 2002
    ....
  36. ncbi SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2
    Christina Spilker
    Project Group Neuroplasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany
    J Neurochem 104:187-201. 2008
    ..Our results imply that SPAR2 is a new RapGAP with specific functions in cerebellar and hippocampal granule cells...
  37. ncbi [Regulation of a small GTPase Rap2]
    Y Ohba
    Laboratory of Molecular and Cellular Pathology, Department of Neurological Disorder, Division of Neurological Science, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
    Hokkaido Igaku Zasshi 76:13-20. 2001
    ..I have found that the GTP-bound form exceeds 50% of total Rap2 in the cells. This observation suggests that Rap2 suppresses Ras-mediated activation of ERK/MAP kinase cascade in quiescent cells...
  38. pmc Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap
    M Spaargaren
    Onyx Pharmaceuticals, Richmond, CA 94806
    Proc Natl Acad Sci U S A 91:12609-13. 1994
    ..Furthermore, we show that RalGDS-RBD and the Ras-binding domain of Raf-1 compete for binding to the Ras-like GTPases. These data indicate that RalGDS is a putative effector molecule for R-ras, H-ras, K-ras, and Rap...
  39. pmc Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions
    Jingliang Yan
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Cell Biol 28:5803-10. 2008
    ..These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of FGF-induced ERK activation...
  40. ncbi Natural history and early diagnosis of LAD-1/variant syndrome
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 109:3529-37. 2007
    ..Defining the primary defect awaits genetic linkage analysis, which may be greatly helped by a more precise understanding and awareness of the disease combined with the early identification of affected patients...
  41. ncbi Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes
    Emily A Oestreich
    Department of Pharmacology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 282:5488-95. 2007
    ..These data define a novel endogenous PKA-independent betaAR-signaling pathway through cAMP-dependent Epac activation, Rap, and PLC(epsilon) that enhances intracellular Ca(2+) release in cardiac myocytes...
  42. pmc Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma
    Zhaocheng Zhang
    Department of Oral Medicine, Pathology, and Oncology, University of Michigan, School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Am J Pathol 168:585-96. 2006
    ..Furthermore, SCC cells transfected with rap1GAP produced significantly smaller tumors in nude mice as compared to controls (P < 0.01). These novel findings suggest that rap1GAP acts as a tumor suppressor protein in SCC...
  43. pmc A class of single-stranded telomeric DNA-binding proteins required for Rap1p localization in yeast nuclei
    L M Konkel
    Department of Plant Biology, University of Minnesota, St Paul 55108, USA
    Proc Natl Acad Sci U S A 92:5558-62. 1995
    ..Furthermore, it demonstrates that, despite their unusual codon bias, C. reinhardtii genes can be efficiently translated in Saccharomyces cerevisiae cells...
  44. pmc The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein
    Elisabetta Mantuano
    Department of Anesthesiology and Pathology, University of California, San Diego, La Jolla, California 92093 0629, USA
    J Neurosci 28:11571-82. 2008
    ..These results establish LRP-1 as a cell-signaling receptor for MMP-9, which may be significant in regulating Schwann cell migration and physiology in PNS injury...
  45. ncbi Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon
    Chunhua Song
    Division of Molecular Biology, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Oncogene 21:8105-13. 2002
    ..Therefore, the phospholipase C signal is suggested to be critical for survival and growth of BaF3 cells...
  46. pmc Rap1 activation plays a regulatory role in pancreatic amylase secretion
    Maria E Sabbatini
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 0622, USA
    J Biol Chem 283:23884-94. 2008
    ..Rap1 activation not only mediates the cAMP-evoked response via Epac1 but is also involved in CCK- and carbachol-induced amylase release, with their action most likely mediated by CalDAG-GEF III...
  47. ncbi MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1
    Hideo Nonaka
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Biochem Biophys Res Commun 377:573-8. 2008
    ..These are novel actions of MINK and TNIK, and consistent with a role of MINK as a Rap2 effector in the brain...
  48. ncbi Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
    Holger Rehmann
    Department of Physiological Chemistry, Centre for Biomedical Genetics and Cancer Genomics Centre, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Nature 455:124-7. 2008
    ....
  49. ncbi Highlighting the role of Ras and Rap during Dictyostelium chemotaxis
    Arjan Kortholt
    Department of Molecular Cell Biology, University of Groningen, Kerklaan 30, 9751NN Haren, The Netherlands
    Cell Signal 20:1415-22. 2008
    ..Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis...
  50. ncbi cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics
    Karen S Lyle
    Department of Physiological Chemistry, Centre for Biomedical Genetics and Cancer Genomics Centre, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Cell Signal 20:1104-16. 2008
    ..This extends beyond the effect of integrin affinity modulation and argues for an additional function of Rap in controlling the migration machinery of epithelial cells...
  51. pmc The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction
    Vladimir Pena
    European Molecular Biology Laboratory, Structural and Computational Biology and Developmental Biology Units, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    EMBO Rep 9:350-5. 2008
    ..SynGAP presents the first example, to our knowledge, of a GAP that uses a second domain for catalytic activity, thus pointing to a new function of C2 domains...
  52. ncbi The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane
    Yu Li
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, and Walther Cancer Institute, Indianapolis, Indiana 46202, USA
    J Biol Chem 281:2506-14. 2006
    ..Therefore, despite its previous description as a Ras antagonist or independently functioning GTPase, Rap1/Krev-1 may additionally act downstream of Ras in cells that express the cyclic AMP-regulated GEF, Epac2...
  53. ncbi cAMP-dependent oncogenic action of Rap1b in the thyroid gland
    Fernando Ribeiro-Neto
    Department of Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 279:46868-75. 2004
    ..These experiments provide conclusive evidence that Rap1b is oncogenic in the thyroid in ways linked to transduction of the cAMP mitogenic signal...
  54. ncbi Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation
    Fabio Greco
    Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    Biochim Biophys Acta 1763:330-5. 2006
    ..In addition, Rap2 segregated and was selectively enriched into microvesicles released by Ca2+ -activated RBCs, suggesting a possible role for this GTPase in membrane shedding...
  55. ncbi Folate deficiency induced hyperhomocysteinemia changes the expression of thrombosis-related genes
    Liselotte S Ebbesen
    Clinical Institute, University Hospital of Aarhus, Skejby Sygehus, Brendstrupgaardsvej, Denmark
    Blood Coagul Fibrinolysis 17:293-301. 2006
    ..This pattern of the hyperhomocysteinemia-affected genes may represent a reference for further studies at the protein level to define the folate depletion effects in blood cells...
  56. ncbi Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons
    Zhanyan Fu
    Georgetown University Medical School, Department of Physiology and Biophysics, Washington, DC 20057, USA
    J Neurochem 100:118-31. 2007
    ..Rap1 and Rap2 thus have overlapping but distinct actions that potentially link the inhibition of synaptic transmission with the retraction of axons and dendrites...
  57. ncbi Identification of genes differentially expressed in human primary lung squamous cell carcinoma
    Yan Liu
    Department of Etiology and Carcinogenesis, Cancer Institute Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, PR China
    Lung Cancer 56:307-17. 2007
    ..The differentially expressed genes reported in this study will provide a valuable resource for understanding the pathogenesis of lung SCCs and for discovery of novel diagnostic or therapeutic targets...
  58. pmc A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways
    Gladys Mirey
    Groupe d Analyse des Réseaux de Transduction, Institut Curie, Inserm U 528, 75248 Paris Cedex 05, France
    Mol Cell Biol 23:1112-24. 2003
    ..Thus, in vivo data show variations in the connectivity of pathways described for cell lines which might display only a subset of the biological possibilities...
  59. ncbi LAD III versus LAD I variant
    Amos Etzioni
    Blood 110:4129; author reply 4129-30. 2007
  60. pmc The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G proteins
    Latika Singh
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, New England Medical Center, Boston, Massachusetts 02111, USA
    J Virol 77:1614-20. 2003
    ..Significantly, we demonstrate that coexpression of HPV16 E6, by promoting the degradation of E6TP1, enhances the GTP loading of Rap. These results support a role of Rap small-G-protein pathway in E6-mediated oncogenesis...
  61. pmc Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis
    Alban Gaultier
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Sci 122:1155-62. 2009
    ..LRP1 colocalized with multiple CNS cell types. These studies establish LRP1 as a major receptor for phagocytosis of degraded myelin, which may function alone or in concert with co-receptors previously implicated in myelin phagocytosis...
  62. ncbi High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway
    Sun Lin
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:41725-35. 2002
    ..This effect appears to be PKC-dependent and PDGF-independent, but involves B-Raf, suggesting a novel PKC-Rap1b-B-Raf pathway responsible for HG-induced increased mesangial matrix synthesis, a hallmark of diabetic nephropathy...
  63. ncbi cDNA cloning, northern hybridization, and mapping analysis of a putative GDS-related protein gene at the centromeric ends of the human and mouse MHC regions
    A Ando
    Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Immunogenetics 49:354-6. 1999
  64. ncbi Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family
    P J Cullen
    Inositide Laboratory, Babraham Institute, Cambridge, UK
    Nature 376:527-30. 1995
    ..In vitro it shows GAP activity against both Rap and Ras, but only the Ras GAP activity is inhibited by phospholipids and is specifically stimulated by Ins(1,3,4,5)P4...
  65. pmc Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae
    C Liu
    Cornell University, Graduate School of Medical Sciences, New York, New York 10021, USA
    Genetics 143:81-93. 1996
    ..We propose that this telomere-specific synergism is mediated in part through stabilization of Rap1p/Sir3p telometric complexes by Sir3p-Sir3p interactions...
  66. ncbi Dimerization of Cdc25p, the guanine-nucleotide exchange factor for Ras from Saccharomyces cerevisiae, and its interaction with Sdc25p
    C Camus
    Laboratoire Information Génétique et Développement, Institut de Genetique et Microbiologie, URA CNRS 2225, Universite Paris Sud, France
    Eur J Biochem 247:703-8. 1997
    ..The biological relevance of dimerization is still an open question, however by allowing heterodimerization with Sdc25p it could permit a more complex combinatorial regulation of ras in yeast...
  67. pmc Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae
    A J Lustig
    Graduate Program in Molecular Biology, Cornell University Graduate School of Medical Sciences, New York, NY 10021, USA
    Mol Cell Biol 16:2483-95. 1996
    ..Internal silencing is enhanced in rap1-17 strains. We propose that sequestration of silencing factors at the telomere limits the efficiency of internal silencing...
  68. pmc GCR1 of Saccharomyces cerevisiae encodes a DNA binding protein whose binding is abolished by mutations in the CTTCC sequence motif
    H V Baker
    Department of Immunology and Medical Microbiology, College of Medicine, University of Florida, Gainesville 32610
    Proc Natl Acad Sci U S A 88:9443-7. 1991
    ..This finding, in addition to the work of others, suggests that the GCR1 gene product and the RAP1/GRF1/TUF gene product act in concert to mediate high-level glycolytic gene expression...
  69. pmc RAP1 is required for BAS1/BAS2- and GCN4-dependent transcription of the yeast HIS4 gene
    C Devlin
    Cold Spring Harbor Laboratory, New York 11724
    Mol Cell Biol 11:3642-51. 1991
    ..These results suggest that RAP1 functions at HIS4 by increasing the accessibility of GCN4, BAS1, and BAS2 to their respective binding sites when these sites are present within chromatin...
  70. ncbi Identification of a specific effector of the small GTP-binding protein Rap2
    I Janoueix-Lerosey
    Unité INSERM 248, Institut Curie, Section de Recherche, Paris, France
    Eur J Biochem 252:290-8. 1998
    ..These data therefore argue for RPIP8 being a specific effector of the Rap2 protein in cells exhibiting neuronal properties...
  71. ncbi Conservation of binding site specificity of three yeast DNA binding proteins
    G H Pretorius
    Department of Microbiology and Biochemistry, University of the Orange Free State, Bloemfontein, South Africa
    FEBS Lett 298:203-5. 1992
    ..The affinities for the probes varied amongst the other yeasts tested, but in general, CPF1 binding activity was the most widespread, while the other two were more limited...
  72. pmc Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation
    M Torti
    Department of Biochemistry, University of Pavia, Italy
    Proc Natl Acad Sci U S A 90:7553-7. 1993
    ..These results clearly demonstrate that changes in the intracellular localization of rap2B occur during platelet activation and represent evidence that this low molecular weight GTP-binding protein may be involved in platelet function...
  73. pmc Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase
    C F Albright
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    EMBO J 12:339-47. 1993
    ..The 3600 nucleotide ralGDS mRNA and the 115 kDa protein were found in all tissues and cell lines examined...
  74. ncbi Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25
    O Riess
    Abteilung für Molekulare Humangenetik, Ruhr Universitat, Bochum, Germany
    Hum Genet 92:629-30. 1993
    ..This chromosomal localization of smg GDP to 4q21-25 overlaps with a region of allele loss in primary hepatocellular carcinoma (4q13-q26)...
  75. ncbi Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus
    R Wienecke
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4040, USA
    Oncogene 13:913-23. 1996
    ..The co-localization of tuberin and Rap1 in vivo strengthens the likelihood that the in vitro catalytic activity of tuberin toward Rap1 plays a physiologically relevant role in the tumor suppressor function of tuberin...
  76. ncbi SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast
    S Strahl-Bolsinger
    Department of Biological Chemistry, University of California, Los Angeles 90095, USA
    Genes Dev 11:83-93. 1997
    ..RAP1 binding at the core region is unaffected by SIR3 overproduction and RAP1 shows no evidence of spreading. Thus, we propose that the structure of core telomeric heterochromatin differs from that extended by SIR3...
  77. pmc GCR1, a transcriptional activator in Saccharomyces cerevisiae, complexes with RAP1 and can function without its DNA binding domain
    J Tornow
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406 5018
    EMBO J 12:2431-7. 1993
    ..RAP1 and GCR1 can be co-immunoprecipitated from whole cell extracts, suggesting that they form a complex in vivo. The data are most consistent with a model in which GCR1 is attracted to DNA through contact with RAP1...
  78. ncbi A mouse CDC25-like product enhances the formation of the active GTP complex of human ras p21 and Saccharomyces cerevisiae RAS2 proteins
    E Jacquet
    National de la Recherche Scientifique, Laboratoire de Biochimie, Ecole Polytechnique, Palaiseau, France
    J Biol Chem 267:24181-3. 1992
    ..Our results show that a cloned GDP to GTP exchange factor of mammalian ras belongs to the novel family of CDC25-like proteins...
  79. pmc Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae
    C Liu
    Graduate Program in Molecular Biology, Cornell University Graduate School of Medical Sciences, New York, New York 10021
    Genetics 138:1025-40. 1994
    ..These data also suggest a distinct set of C-terminal requirements for telomere size control and telomeric silencing...
  80. ncbi Estrogen increases smooth muscle expression of alpha2C-adrenoceptors and cold-induced constriction of cutaneous arteries
    A H Eid
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA
    Am J Physiol Heart Circ Physiol 293:H1955-61. 2007
    ..An estrogen-dependent increase in expression of cold-sensitive alpha(2C)-ARs may contribute to the increased activity of cold-induced vasoconstriction under estrogen-replete conditions...
  81. pmc Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation
    Z Wang
    Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7260, USA
    J Thromb Haemost 7:693-700. 2009
    ..However, signaling molecules that regulate alpha2beta1 activation in platelets are not well defined. A strong candidate molecule is the small GTPase Rap1b, the dominant platelet isoform of Rap1, which regulates alphaIIbbeta3 activation...
  82. ncbi The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue
    N Nassar
    Max Planck Institut fur molekulare Physiologie, Abteilung Strukturelle Biologie, Dortmund, Germany
    Nature 375:554-60. 1995
    ..Complex formation is mediated by main-chain and side-chain interactions of the so-called effector residues in the switch I region of Rap1A...
  83. ncbi The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity
    Jens C Schwamborn
    Abteilung Molekularbiologie, Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat Munster, Schlossplatz 5, D 48149 Munster, Germany
    J Biol Chem 282:35259-68. 2007
    ..Interfering with the binding of mPar3 to Kinesin-2 or Smurf2 to mPar3 and knockdown of mPar3 by RNAi disrupt the establishment of neuronal polarity through the failure to restrict Rap1B to a single neurite...
  84. ncbi RAP1: a protean regulator in yeast
    D Shore
    Department of Microbiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032
    Trends Genet 10:408-12. 1994
    ..At the ends of chromosomes, RAP1 plays an important role in both silencing (telomere position effect) and telomere structure...
  85. pmc Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation
    Simona Citro
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:15543-8. 2007
    ..Thus, PLCepsilon serves to transduce mitogenic signals through a mechanism distinct from its role in generation of PLC-derived second messengers...
  86. ncbi The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes
    Caylib A Durand
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    Eur J Immunol 36:2235-49. 2006
    ..This suggests that the ability of CXCL13 and S1P to direct the trafficking and localization of B cells in vivo may be dependent on Rap activation...
  87. pmc Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression
    M Hattori
    Department of Immunology and Cell Biology, Faculty of Medicine, Kyoto University, Japan
    Mol Cell Biol 15:552-60. 1995
    ..Functions of the Spa-1 protein and its regulation are discussed in the context of its possible interaction with the Ran/RCC-1 system, which is involved in the coordinated nuclear functions, including cell division...
  88. pmc A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors
    Gromoslaw A Smolen
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 21:2131-6. 2007
    ..We specifically show that these defects are primarily due to the diminished migratory capacity of NC cells. The identification of RADIL as a regulator of NC migration defines a role for the Rap pathway in this process...
  89. ncbi Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states
    Mohammad T Mazhab-Jafari
    Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4M1, Canada
    J Am Chem Soc 129:14482-92. 2007
    ..The proposed mechanism of allosteric activation will serve as a basis to understand agonism and antagonism in the EPAC system and provides also a general paradigm for how small ligands control protein-protein interfaces...
  90. ncbi Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region
    V Pizon
    INSERM U 248, Faculte de Medecine Lariboisiere Saint Louis, Paris, France
    Oncogene 3:201-4. 1988
    ..This suggests that the rap proteins might interact with the same effector as the ras proteins...
  91. pmc Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop
    Martin M Edreira
    Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:27480-6. 2009
    ..These results provide a mechanistic explanation for the differential effects of Rap1 phosphorylation by PKA on effector protein interaction...
  92. ncbi Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets
    Ilaria Canobbio
    Department of Biochemistry, University of Pavia, via Bassi 21, Pavia, Italy
    Blood 114:2193-6. 2009
    ..These results provide genetic evidence for a crucial and selective role of PI3Kbeta in signaling through GPVI and integrin alpha(IIb)beta(3)...
  93. ncbi The stimulatory GDP/GTP exchange protein for ras p21-related small GTP-binding proteins
    T Yamamoto
    Department of Biochemistry, Kobe University School of Medicine
    Kobe J Med Sci 38:37-56. 1992
    ..It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP...
  94. pmc EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation
    Elaine Huston
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Proc Natl Acad Sci U S A 105:12791-6. 2008
    ..Through this signaling system EPAC activation can thereby impact on the Ser-473 phosphorylation status of PKB/Akt and the repair of etoposide-induced DSBs...
  95. ncbi A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
    C F Hardy
    Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Genes Dev 6:801-14. 1992
    ..By use of the two-hybrid system, we have isolated a mutation in RIF1 that partially restores the interaction with rap1s mutant proteins...
  96. pmc Genetic analysis of the K-rev-1 transformation-suppressor gene
    H Kitayama
    Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Environ Health Perspect 93:73-7. 1991
    ..These findings are consistent with the idea that K-rev-1 protein is regulated like many other G-proteins by guanine triphosphate/guanine diphosphate-exchange mechanism probably in response to certain negative growth-regulatory signals...
  97. ncbi Regulation of activin/nodal signaling by Rap2-directed receptor trafficking
    Sun Cheol Choi
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, San31, Hyoja Dong, Pohang, Kyungbuk 790 784, Korea
    Dev Cell 15:49-61. 2008
    ..Therefore, these findings suggest a molecular basis for the regulation of signaling activity and embryonic patterning by Activin/Nodal receptor trafficking...
  98. ncbi Rsr1 and Rap1 GTPases are activated by the same GTPase-activating protein and require threonine 65 for their activation
    J L Holden
    Melbourne Tumor Biology Branch, Ludwig Institute for Cancer Research, Victoria, Australia
    J Biol Chem 266:16992-5. 1991
    ..Replacement of Thr-35 by Ala in the common effector domain (residues 32-40) of the chimeric Ras/Rsr1 GTPases completely abolishes GAP3-dependent activation...
  99. pmc SDC25, a CDC25-like gene which contains a RAS-activating domain and is a dispensable gene of Saccharomyces cerevisiae
    F Damak
    Institut de Génétique et de Microbiologie, Centre National de la Recherche Scientifique URA 1354, Universite Paris Sud, Orsay, France
    Mol Cell Biol 11:202-12. 1991
    ..The SDC25 gene was found to be dispensable for cell growth under usual conditions. No noticeable phenotype was found in the deleted strain...
  100. pmc Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein
    Y Matsui
    Research Center, Mitsubishi Kasei Corporation, Yokohama, Japan
    Mol Cell Biol 10:4116-22. 1990
    ..This fact has raised the possibility that smg p25A GDI interacts with another G protein in tissues in which smg p25A is absent...
  101. ncbi Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins
    T Yamamoto
    Department of Biochemistry, Kobe University School of Medicine, Japan
    J Biol Chem 265:16626-34. 1990
    ..It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP...

Research Grants6

  1. ANALYSIS OF NEUROFIBROMATOSIS TYPE 1 GENE FUNCTION
    Andre Bernards; Fiscal Year: 2003
    ..These studies will help us understand the normal function of the NF1 gene in vivo and will contribute to our understanding of the diverse manifestations of the disease process. ..
  2. A Universal Mouse Line to Assess Tumor Clonality
    Daniel Altschuler; Fiscal Year: 2006
    ..Therefore, we consider this line will be of interest to other NIH institutes (e.g. NIDDK, NIEHS, NCI) and that will contribute significantly to many areas of research. ..
  3. INTERACTION OF RHO GTPASES WITH REGULATORS AND EFFECTORS
    Yi Zheng; Fiscal Year: 2007
    ....
  4. Targeting RhoA Lymphomagenesis
    Yi Zheng; Fiscal Year: 2007
    ..These studies will provide an animal model to implicate RhoA GTPase in tumorigenesis and for testing anti-cancer strategies by targeting RhoA pathways. [unreadable] [unreadable] [unreadable]..
  5. Rho GTPase-Activating Proteins in Cancer
    Yi Zheng; Fiscal Year: 2008
    ..These studies will provide mechanistic insights into the regulatory function of RhoGAPs in cell signaling and may generate therapeutic reagents targeting Rho GTPase pathways in human cancers. ..
  6. Dbl-like Regulators of Small GTP-binding Proteins
    Yi Zheng; Fiscal Year: 2008
    ..The results may also provide valuable pharmacological reagents for the intervention of the GEF-mediated signaling. ..