mitogen activated protein kinases

Summary

Summary: A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).

Top Publications

  1. ncbi Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    Gary L Johnson
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 298:1911-2. 2002
  2. ncbi Mammalian MAP kinase signalling cascades
    L Chang
    Department of Pharmacology, University of California San Diego, La Jolla 92093-0636, USA
    Nature 410:37-40. 2001
  3. ncbi Signal transduction by the JNK group of MAP kinases
    R J Davis
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    Cell 103:239-52. 2000
  4. pmc SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
    B L Bennett
    Signal Research Division, Celgene Corporation, 5555 Oberlin Drive, San Diego, CA 92121 USA
    Proc Natl Acad Sci U S A 98:13681-6. 2001
  5. ncbi Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
    G Pearson
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Endocr Rev 22:153-83. 2001
  6. ncbi Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    J M Kyriakis
    Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Physiol Rev 81:807-69. 2001
  7. ncbi Mutations of the BRAF gene in human cancer
    Helen Davies
    Cancer Genome Project, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
    Nature 417:949-54. 2002
  8. ncbi A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    J C Lee
    Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406
    Nature 372:739-46. 1994
  9. ncbi MAP kinases in the immune response
    Chen Dong
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195 7650, USA
    Annu Rev Immunol 20:55-72. 2002
  10. pmc Osmotic stress signaling and osmoadaptation in yeasts
    Stefan Hohmann
    Department of Cell and Molecular Biology Microbiology, Goteborg University, S 405 30 Goteborg, Sweden
    Microbiol Mol Biol Rev 66:300-72. 2002

Detail Information

Publications348 found, 100 shown here

  1. ncbi Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    Gary L Johnson
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 298:1911-2. 2002
    ..The p38 MAPKs are activated by inflammatory cytokines and environmental stresses and may contribute to diseases like asthma and autoimmunity...
  2. ncbi Mammalian MAP kinase signalling cascades
    L Chang
    Department of Pharmacology, University of California San Diego, La Jolla 92093-0636, USA
    Nature 410:37-40. 2001
    ....
  3. ncbi Signal transduction by the JNK group of MAP kinases
    R J Davis
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    Cell 103:239-52. 2000
  4. pmc SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
    B L Bennett
    Signal Research Division, Celgene Corporation, 5555 Oberlin Drive, San Diego, CA 92121 USA
    Proc Natl Acad Sci U S A 98:13681-6. 2001
    ..Our study supports targeting JNK as an important strategy in inflammatory disease, apoptotic cell death, and cancer...
  5. ncbi Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
    G Pearson
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Endocr Rev 22:153-83. 2001
    ..This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2...
  6. ncbi Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    J M Kyriakis
    Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Physiol Rev 81:807-69. 2001
    ..The nuclear factor-kappa B pathway, a second stress signaling paradigm, has been the subject of several excellent recent reviews (258, 260)...
  7. ncbi Mutations of the BRAF gene in human cancer
    Helen Davies
    Cancer Genome Project, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
    Nature 417:949-54. 2002
    ..As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human cancer, it may provide new therapeutic opportunities in malignant melanoma...
  8. ncbi A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    J C Lee
    Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406
    Nature 372:739-46. 1994
    ..Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production...
  9. ncbi MAP kinases in the immune response
    Chen Dong
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195 7650, USA
    Annu Rev Immunol 20:55-72. 2002
    ..In this review, we summarize recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses...
  10. pmc Osmotic stress signaling and osmoadaptation in yeasts
    Stefan Hohmann
    Department of Cell and Molecular Biology Microbiology, Goteborg University, S 405 30 Goteborg, Sweden
    Microbiol Mol Biol Rev 66:300-72. 2002
    ....
  11. ncbi AP-1 as a regulator of cell life and death
    Eitan Shaulian
    Department of Experimental Medicine and Cancer Research, School of Medicine, The Hebrew University, Jerusalem, 91120, Israel
    Nat Cell Biol 4:E131-6. 2002
    ..Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed...
  12. ncbi Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
    C Tournier
    Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 288:870-4. 2000
    ..These data indicate that mitochondria are influenced by proapoptotic signal transduction through the JNK pathway...
  13. ncbi BRAF and RAS mutations in human lung cancer and melanoma
    Marcia S Brose
    Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia 19104, USA
    Cancer Res 62:6997-7000. 2002
    ..Although uncommon, BRAF mutations in human lung cancers may identify a subset of tumors sensitive to targeted therapy...
  14. ncbi Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  15. ncbi Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    J Raingeaud
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    J Biol Chem 270:7420-6. 1995
    ..Immunofluorescence microscopy demonstrated that p38 MAP kinase is present in both the nucleus and cytoplasm of activated cells. Together, these data establish that p38 is a member of the mammalian MAP kinase group...
  16. ncbi JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    B Derijard
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605
    Cell 76:1025-37. 1994
    ..Thus, JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation. These properties indicate that JNK1 activation may play an important role in tumor promotion...
  17. ncbi Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
    L M Luttrell
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 283:655-61. 1999
    ....
  18. ncbi Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
    T Sasaki
    Amgen Institute, 620 University Avenue, Toronto M5G 2C1, Ontario, Canada
    Science 287:1040-6. 2000
    ..Thus, PI3Kgamma regulates thymocyte development, T cell activation, neutrophil migration, and the oxidative burst...
  19. pmc The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response
    Hideki Inoue
    Department of Molecular Biology, Graduate School of Science, Institute for Advanced Research, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Genes Dev 19:2278-83. 2005
    ..These results delineate the C. elegans p38 MAPK signaling pathway leading to the nucleus that responds to oxidative stress...
  20. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
    ..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
  21. ncbi The stress-activated protein kinase subfamily of c-Jun kinases
    J M Kyriakis
    Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital East, Charlestown 02129
    Nature 369:156-60. 1994
    ..9). SAPKs therefore define a new TNF-alpha and stress-activated signalling pathway, possibly initiated by sphingomyelin-based second messengers, which regulates the activity of c-Jun...
  22. pmc Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    M Deak
    MRC Protein Phosphorylation Unit, Departments of Biochemistry, Anatomy and Physiology, University of Dundee, Scotland
    EMBO J 17:4426-41. 1998
    ..These findings, together with other observations, suggest that MSK1 may mediate the growth-factor and stress-induced activation of CREB...
  23. ncbi A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity
    Dennis H Kim
    Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Science 297:623-6. 2002
    ..These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species...
  24. pmc Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
    W Kolch
    The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, U K
    Biochem J 351:289-305. 2000
    ....
  25. pmc ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    Philippe P Roux
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Microbiol Mol Biol Rev 68:320-44. 2004
    ..In this article, we review the existing data on the MKs and discuss their physiological functions based on recent discoveries...
  26. pmc Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
    Nick I Markevich
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    J Cell Biol 164:353-9. 2004
    ..Hence, bistability induced by multisite covalent modification may be a widespread mechanism of the control of protein activity...
  27. ncbi The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    C Y Kuan
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Neuron 22:667-76. 1999
    ..In contrast, increased apoptosis and caspase activation were found in the mutant forebrain, leading to precocious degeneration. These results suggest that Jnk1 and Jnk2 regulate region-specific apoptosis during early brain development...
  28. ncbi MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis
    A Kotlyarov
    Martin Luther University Halle Wittenberg, Germany
    Nat Cell Biol 1:94-7. 1999
    ..We conclude that MK2 is an essential component in the inflammatory response which regulates biosynthesis of TNF-alpha at a post-transcriptional level...
  29. ncbi Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 386:296-9. 1997
    ..One consequence of MEF2C activation is increased c-jun gene transcription. Our results show that p38 may influence host defence and inflammation by maintaining the balance of c-Jun protein consumed during infection...
  30. pmc Disease resistance and abiotic stress tolerance in rice are inversely modulated by an abscisic acid-inducible mitogen-activated protein kinase
    Lizhong Xiong
    Department of Plant Pathology and Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Plant Cell 15:745-59. 2003
    ..These results strongly suggest that OsMAPK5 can positively regulate drought, salt, and cold tolerance and negatively modulate PR gene expression and broad-spectrum disease resistance...
  31. ncbi Anchorage-dependent ERK signaling--mechanisms and consequences
    Alan K Howe
    University of North Carolina, Chapel Hill, School of Medicine, Department of Pharmacology, Campus Box 7365, Chapel Hill, North Carolina 27599 3765, USA
    Curr Opin Genet Dev 12:30-5. 2002
    ..Recent work has demonstrated that cell adhesion can regulate ERK signaling at several checkpoints and has begun to define the mechanism and consequences associated with anchorage-dependent effects on the ERK cascade...
  32. ncbi A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    J Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 265:808-11. 1994
    ..Both HOG1 and p38 are tyrosine phosphorylated after extracellular changes in osmolarity. These findings link a signaling pathway in mammalian cells with a pathway in yeast that is responsive to physiological stress...
  33. ncbi Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor
    F Posas
    Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 86:865-75. 1996
    ..We propose that the multistep phosphorelay mechanism is a universal signal transduction apparatus utilized both in prokaryotes and eukaryotes...
  34. pmc Cell wall integrity signaling in Saccharomyces cerevisiae
    David E Levin
    Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Microbiol Mol Biol Rev 69:262-91. 2005
    ....
  35. ncbi A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
    Jorrit M Enserink
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands
    Nat Cell Biol 4:901-6. 2002
    ..Moreover, in cell lines in which cAMP activates ERK, inhibition of PKA and Ras, but not Rap1, abolished cAMP-mediated ERK activation. We conclude that cAMP-induced regulation of ERK and activation of Rap1 are independent processes...
  36. ncbi Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation
    Philip J S Stork
    Vollum Institute and the Dept of Cell and Developmental Biology, Oregon Health and Science University, Portland, OR 97201, USA
    Trends Cell Biol 12:258-66. 2002
    ..Emerging new data suggest that one of these mechanisms might involve the activation of the GTPase Rap1, which can activate or inhibit ERK signaling in a cell-specific manner...
  37. pmc p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
    Emily R Troemel
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e183. 2006
    ..The contribution of the PMK-1 pathway to the enhanced lifespan of daf-2 mutants suggests that innate immunity is an important determinant of longevity...
  38. ncbi Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation
    J M Brondello
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue de Valombrose, Nice 06189, France
    Science 286:2514-7. 1999
    ..These results illustrate the importance of regulated protein degradation in the control of mitogenic signaling...
  39. ncbi Defective T cell differentiation in the absence of Jnk1
    C Dong
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 282:2092-5. 1998
    ..Thus, the JNK1 signaling pathway plays a key role in T cell receptor-initiated TH cell proliferation, apoptosis, and differentiation...
  40. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
    ..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
  41. ncbi Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
    Lindsey A Allan
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Nat Cell Biol 5:647-54. 2003
    ..This mechanism may also contribute to tumorigenesis when the ERK MAPK pathway is constitutively activated...
  42. ncbi Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense
    A W Roberts
    Howard Hughes Medical Institute, and Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Immunity 10:183-96. 1999
    ..Rac2 is an essential regulator of multiple specialized neutrophil functions...
  43. ncbi Translational control by MAPK signaling in long-term synaptic plasticity and memory
    Raymond J Kelleher
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Departments of Biology and Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA
    Cell 116:467-79. 2004
    ..These results suggest a crucial role for translational control by MAPK signaling in long-lasting forms of synaptic plasticity and memory...
  44. ncbi Fas engagement induces neurite growth through ERK activation and p35 upregulation
    Julie Desbarats
    Department of Physiology, McGill University, Montreal, Quebec, Canada, H3G 1Y6
    Nat Cell Biol 5:118-25. 2003
    ..Our findings define a role for Fas as an inducer of both neurite growth in vitro and accelerated recovery after nerve injury in vivo...
  45. ncbi IRAK-M is a negative regulator of Toll-like receptor signaling
    Koichi Kobayashi
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 110:191-202. 2002
    ..Endotoxin tolerance, a protection mechanism against endotoxin shock, was significantly reduced in IRAK-M(-/-) cells. Thus, IRAK-M regulates TLR signaling and innate immune homeostasis...
  46. ncbi Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1
    Xavier Escote
    Cell Signaling Unit, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, E 08003 Barcelona, Spain
    Nat Cell Biol 6:997-1002. 2004
    ..Together, our data indicate that the Sic1 CDK-inhibitor is the molecular target for the SAPK Hog1 that is required to modulate cell-cycle progression in response to stress...
  47. pmc MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts
    Giselle R Wiggin
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Mol Cell Biol 22:2871-81. 2002
    ..The transcription of egr1 in response to both mitogenic and stress stimuli, as well as stress-induced apoptosis, was unaffected in the MSK1/MSK2 double knockout...
  48. ncbi Ancient signals: comparative genomics of plant MAPK and MAPKK gene families
    Louis Philippe Hamel
    Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, 1055 du PEPS, Sainte Foy, Quebec, Canada G1V 4C7
    Trends Plant Sci 11:192-8. 2006
    ..The Arabidopsis MAPK nomenclature appears sufficiently robust to allow it to be usefully extended to other well-characterized plant systems...
  49. ncbi The death domain kinase RIP mediates the TNF-induced NF-kappaB signal
    M A Kelliher
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 8:297-303. 1998
    ..Sensitivity to TNFalpha-mediated cell death in rip-/- cells is accompanied by a failure to activate the transcription factor NF-kappaB...
  50. ncbi TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
    C D Dumitru
    Kimmel Cancer Center, Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    Cell 103:1071-83. 2000
    ..Subcellular fractionation of LPS-stimulated macrophages revealed that LPS signals transduced by Tpl2 specifically promote the transport of TNF-alpha mRNA from the nucleus to the cytoplasm...
  51. ncbi The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells
    K M Ardeshna
    Department of Haematology, Royal Free and University College Medical School, London, United Kingdom
    Blood 96:1039-46. 2000
    ..It thus appears that different aspects of LPS-induced MoDC maturation are regulated by different and sometimes overlapping pathways...
  52. ncbi p38 MAP kinases: beyond the stress response
    A R Nebreda
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Trends Biochem Sci 25:257-60. 2000
  53. ncbi Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe
    Marisa Madrid
    Departamento de Genética y Microbiología, Facultad de Biologia, University of Murcia, Camous Universitario de Espinardo, Murcia 30071, Spain
    J Biol Chem 281:2033-43. 2006
    ..These results provide the first evidence for the existence of cross-talk between two MAPK cascades during the stress response in fission yeast...
  54. pmc Mitogen activated protein kinases: a role in inflammatory bowel disease?
    O J Broom
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Clin Exp Immunol 158:272-80. 2009
    Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades...
  55. ncbi Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
    H Enslen
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605, USA
    J Biol Chem 273:1741-8. 1998
    ..The MKK3 and MKK6 signal transduction pathways are therefore coupled to distinct, but overlapping, groups of p38 MAP kinases...
  56. ncbi Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
    D V Bulavin
    Division of Basic Science, National Cancer Intitute, National Institutes of Health, Bethesda, MD 20892, USA
    Nature 411:102-7. 2001
    ..We propose that regulation of Cdc25B phosphorylation by p38 is a critical event for initiating the G2/M checkpoint after ultraviolet radiation...
  57. pmc The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation
    Matthew Good
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 136:1085-97. 2009
    ..The dual requirement for both Ste7 and this Ste5 domain in Fus3 activation explains why Fus3 is selectively activated by the mating pathway and not by other pathways that also utilize Ste7...
  58. ncbi Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
    D D Yang
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 389:865-70. 1997
    ..These data indicate that the observed neuroprotection is due to the extinction of a Jnk3-mediated signalling pathway, which is an important component in the pathogenesis of glutamate neurotoxicity...
  59. ncbi Yeast osmoregulation
    Stefan Hohmann
    Department of Cell and Molecular Biology, Goteborg University, Goteborg, Sweden
    Methods Enzymol 428:29-45. 2007
    ..Simulations using mathematical models combined with time course measurements of different molecular processes in signaling and adaptation have allowed elucidation of the first system properties on the yeast osmoregulatory network...
  60. ncbi Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly
    Shawn M Sweeney
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:30516-24. 2003
    ..Thus capillary morphogenesis requires endothelial alpha2beta1 integrin engagement of a single type I collagen integrin-binding site, possibly signaling via p38 MAPK and focal adhesion disassembly/FAK inactivation...
  61. ncbi Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB
    T Shalom-Barak
    Division of Arthritis Research, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 273:27467-73. 1998
    ..These results suggest that IL-17 activation of chondrocytes is associated with and depends at least in part on the activation of MAP kinases and NF-kappaB...
  62. pmc Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR
    Katie L Styer
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 322:460-4. 2008
    ..elegans, suggesting that GPCRs may participate in neural circuits that receive inputs from either pathogens or infected sites and integrate them to coordinate appropriate immune responses...
  63. pmc Selective interaction of JNK protein kinase isoforms with transcription factors
    S Gupta
    Program in Moleular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    EMBO J 15:2760-70. 1996
    ..Individual members of the JNK group may therefore selectively target specific transcription factors in vivo...
  64. pmc The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor
    R Beyaert
    Laboratory of Molecular Biology, University of Ghent, Belgium
    EMBO J 15:1914-23. 1996
    ..Interestingly, TNF-induced cytotoxicity was not affected by SB203580, indicating that p38 MAP kinase might be an interesting target to interfere selectively with TNF-induced gene activation...
  65. ncbi Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
    K Sabapathy
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Mech Dev 89:115-24. 1999
    ..These results assign both pro- and anti-apoptotic functions for JNK1 and JNK2 in the development of the fetal brain...
  66. ncbi c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions
    T Kallunki
    Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla 92093 0636, USA
    Cell 87:929-39. 1996
    ..Substrates such as JunD can be phosphorylated by JNK through heterodimerization with docking competent partners. Therefore, heterodimerization can affect the recognition of transcription factors by signal-regulated protein kinases...
  67. ncbi Regulation of the osmoregulatory HOG MAPK cascade in yeast
    Haruo Saito
    Division of Molecular Cell Signaling, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biochem 136:267-72. 2004
    ..The subcellular localizations of the osmosensors (Sln1 and Sho1), kinases (Pbs2, Hog1), and phosphatases in the HOG pathway are intricately regulated to achieve their specific functions...
  68. pmc Yeast Mpk1 mitogen-activated protein kinase activates transcription through Swi4/Swi6 by a noncatalytic mechanism that requires upstream signal
    Ki Young Kim
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, E8135, The Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Cell Biol 28:2579-89. 2008
    ....
  69. ncbi The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation
    Y Chu
    Labortory of Pathology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:6497-501. 1996
    ..A hyperactive allele of ERK2 (D319N), analogous to the Drosophila sevenmaker gain-of-function mutation, has significantly reduced sensitivity to all three MAP kinase phosphatases in vivo...
  70. ncbi Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast
    K Shiozaki
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Nature 378:739-43. 1995
    ..Spc1 is inactivated by Pyp1, a phosphatase previously identified as a mitotic inhibitor. Pyp1 dephosphorylates only tyrosine-173 of Spc1, unlike the dual-specificity phosphatases that have been shown to regulate other MAP kinases...
  71. ncbi Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53
    S S Bacus
    Quantitative Diagnostic Laboratories, Inc, Elmhurst, Illinois 60126, USA
    Oncogene 20:147-55. 2001
    ..However, p53 may serve as a survival factor in breast carcinoma cells treated with Taxol by blocking cells in G2/M phase of the cell cycle...
  72. ncbi Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
    K Y Choi
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Cell 78:499-512. 1994
    ..Ste5 also increases the amount of Ste11 complexed to Ste7 and Fus3 and is required for Ste11 to function. These results substantiate a novel signal transduction component that physically links multiple kinases within a single cascade...
  73. ncbi Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress
    Markus Proft
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 9:1307-17. 2002
    ..Cyc8-Tup1 is not simply a corepressor but is also involved in recruiting SWI/SNF and SAGA during the transcriptional induction process...
  74. pmc A sphingolipid elicitor-inducible mitogen-activated protein kinase is regulated by the small GTPase OsRac1 and heterotrimeric G-protein in rice 1[w]
    Damien Lieberherr
    Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology, Ikoma, Nara 630 0101, Japan
    Plant Physiol 138:1644-52. 2005
    ..These results indicate that these two G-proteins regulate an elicitor-inducible MAPK in rice at the protein level...
  75. ncbi MAP kinase activation in macrophages
    K M Rao
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Leukoc Biol 69:3-10. 2001
    ..Therefore, it is important to use primary cells for studying MAPK signal-transduction pathways, and the data from cell lines should not be extrapolated to primary cells...
  76. ncbi Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments
    J Albanell
    Laboratory of Oncology Research, Medical Oncology Service, Vall d'Hebron University Hospital, Barcelona, Spain
    Cancer Res 61:6500-10. 2001
    ..The inhibition of ERK1/2 activation in vitro and in vivo by compounds targeting the EGF receptor points to the interest of ERK1/2 as potential surrogate markers of EGF-receptor signaling in clinical therapeutic studies...
  77. ncbi MAPK cascades in plant defense signaling
    S Zhang
    Dept Biochemistry, University of Missouri Columbia, 117 Schweitzer Hall, Columbia, MO 65211, USA
    Trends Plant Sci 6:520-7. 2001
    ..By contrast, loss-of-function studies of other MAPK pathways revealed negative regulation of disease resistance. This 'push-and-pull' regulation by different MAPK pathways might provide a more precise control of plant defense responses...
  78. pmc Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II
    Paula M Alepuz
    Cell Signaling Unit, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra UPF, E 08003 Barcelona, Spain
    EMBO J 22:2433-42. 2003
    ..The mammalian p38 also interacts with the RNA Pol II, which might suggest a conserved mechanism for regulation of gene expression by SAPKs among eukaryotic cells...
  79. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
    ..Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor...
  80. ncbi The role of NADPH oxidase and MAP kinase phosphatase in UV-B-dependent gene expression in Arabidopsis
    Irina Kalbina
    Department of Science and Orebro Life Science Center, Orebro University, S 70182 Orebro, Sweden
    Plant Cell Environ 29:1783-93. 2006
    ..This suggests a complex dependency of the MAPK phosporylation level of the PR and PDF1.2 genes. Both NADPH oxidase mutants and the mkp1 mutant phenotypically responded to UV-B by growth retardation...
  81. pmc VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells
    Ayelet Shay-Salit
    Department of Anatomy and Cell Biology, Bruce Rappaport Research Institute and the Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
    Proc Natl Acad Sci U S A 99:9462-7. 2002
    ..These results suggest that VEGF receptor 2 and the adherens junction act as shear-stress cotransducers, mediating the transduction of shear-stress signals into vascular endothelial cells...
  82. ncbi A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
    K K Wary
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 94:625-34. 1998
    ..These findings reveal an unexpected function of caveolin-1 and Fyn in integrin signaling and anchorage-dependent cell growth...
  83. pmc Activation of Rac1 by a Crk SH3-binding protein, DOCK180
    E Kiyokawa
    Department of Pathology, National Institute of Infectious Diseases, Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Genes Dev 12:3331-6. 1998
    ..Dominant-negative Rac1 suppressed DOCK180-induced membrane spreading. These results strongly suggest that DOCK180 is a novel activator of Rac1 and involved in integrin signaling...
  84. pmc Heavy metal stress. Activation of distinct mitogen-activated protein kinase pathways by copper and cadmium
    Claudia Jonak
    Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences and Institute of Microbiology and Genetics, University of Vienna, Vienna Biocenter, A 1030 Vienna, Austria
    Plant Physiol 136:3276-83. 2004
    ..These results suggest that plants respond to heavy metal stress by induction of several distinct MAPK pathways and that excess amounts of copper and cadmium ions induce different cellular signaling mechanisms in roots...
  85. ncbi Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer
    Shazli N Malik
    Department of Surgery, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Clin Cancer Res 8:1168-71. 2002
    ....
  86. ncbi Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells
    Laurie M Zipper
    Department of Pharmacology, K4 554 Clinical Sciences Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Toxicol Sci 73:124-34. 2003
    ....
  87. pmc Real-time monitoring of calcineurin activity in living cells: evidence for two distinct Ca2+-dependent pathways in fission yeast
    Lu Deng
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Mol Biol Cell 17:4790-800. 2006
    ....
  88. ncbi Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells
    A S Oh
    Lombardi Cancer Center, Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Mol Endocrinol 15:1344-59. 2001
    ....
  89. pmc Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins
    Danielle L Huffman
    Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, 92093, USA
    Proc Natl Acad Sci U S A 101:10995-1000. 2004
    ..Our data demonstrate that cells defend against pore-forming toxins by means of conserved MAPK pathways...
  90. ncbi ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
    T G Boulton
    Department of Pharmacology, University of Texas Southwestern Graduate School of Biomedical Sciences, Dallas 75235 9041
    Cell 65:663-75. 1991
    ..Individual family members may mediate responses in different developmental stages, in different cell types, or following exposure to different extracellular signals...
  91. ncbi Multiple control of interleukin-8 gene expression
    Elke Hoffmann
    Institute of Pharmacology, Medical School Hannover, Germany
    J Leukoc Biol 72:847-55. 2002
    ..In that way, cells are able to rapidly increase and at the same time, to fine-tune the amount of IL-8 secreted and thereby control the extent of leukocytes attracted to sites of tissue injury...
  92. pmc Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast
    Nadia Vadaie
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Cell Biol 181:1073-81. 2008
    ..We postulate that cleavage-dependent activation is a general feature of signaling mucins, which brings to light a novel regulatory aspect of this class of signaling adhesion molecule...
  93. ncbi Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)
    Y Jiang
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 271:17920-6. 1996
    ..The data reported here suggest that while closely related, p38beta and p38 may be regulated by differing mechanisms and may exert their actions on separate downstream targets...
  94. pmc RAGE signaling in inflammation and arterial aging
    Li Lin
    Laboratory of Cardiovascular Sciences, National Institute on Aging, Baltimore, Maryland, 21224, USA
    Front Biosci (Landmark Ed) 14:1403-13. 2009
    ..This review attempts to provide a comprehensive summary on both recent findings and missing pieces of the RAGE puzzle...
  95. pmc The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae
    S M O'Rourke
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143 0448, USA
    Genes Dev 12:2874-86. 1998
    ..Finally, we have found that pseudohyphal growth exhibited by wild-type (HOG1) strains depends on SHO1, suggesting that Sho1p may be a receptor that feeds into the pseudohyphal growth pathway...
  96. ncbi BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways
    Ayse B Celil
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 280:31353-9. 2005
    ..In addition to Runx2, other signaling components may be necessary to regulate Osx during osteoblast lineage progression...
  97. pmc A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae
    J Verna
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 94:13804-9. 1997
    ..The functional characteristics and cellular localization of WSC suggest that they may mediate intracellular responses to environmental stress in yeast...
  98. pmc Mitogen-activated protein kinase is involved in abscisic acid-induced antioxidant defense and acts downstream of reactive oxygen species production in leaves of maize plants
    Aying Zhang
    College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, People s Republic of China
    Plant Physiol 141:475-87. 2006
    ..ABA-induced H(2)O(2) production activates MAPK, which in turn induces the expression and the activities of antioxidant enzymes. The activation of MAPK also enhances the H(2)O(2) production, forming a positive feedback loop...
  99. pmc Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1
    O Kassel
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, PO Box 3640, D-76021 Karlsruhe, Germany
    EMBO J 20:7108-16. 2001
    ..These results identify MKP-1 as essential for glucocorticoid-mediated control of Erk-1/2 activation and unravel a novel regulatory mechanism for this anti-inflammatory drug...
  100. ncbi Investigating the caffeine effects in the yeast Saccharomyces cerevisiae brings new insights into the connection between TOR, PKC and Ras/cAMP signalling pathways
    Klaudia Kuranda
    Institute of Biochemistry and Biophysics, Warsaw, Poland
    Mol Microbiol 61:1147-66. 2006
    ..This result may pose Rom2p as a mediator in the interplay between Tor1p and the Ras/cAMP pathway...
  101. ncbi Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
    M Hibi
    Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla 92093 0636
    Genes Dev 7:2135-48. 1993
    ..Therefore the binding of JNK to c-Jun is of regulatory importance and suggests a mechanism through which protein kinase cascades can specifically modulate the activity of distinct nuclear targets...

Research Grants64

  1. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    ..ER1, epidermal growth factor receptors (EGFR), insulin growth factor-1 receptors (IGF-1R) and mitogen activated protein kinases (MAPK) (Aim II);and, Action of soy isoflavones in Sertoli cells affects Leydig cells (Aim III)...
  2. REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASES
    Melanie H Cobb; Fiscal Year: 2012
    ..Understanding the mechanisms of action of this family will provide significant insights into the control of ion balance and other essential processes, and may reveal novel strategies to develop anti-hypertensive therapies. ..
  3. Trichothecene Toxicity and the Ribotoxic Stress Response
    James J Pestka; Fiscal Year: 2012
    ..Collectively, these outcomes will positively impact public health by providing a scientific basis for generating sound recommendations relative to these important toxins and appropriate remedial actions should exposures occur. ..
  4. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..at 3 time points: at 1 h post reperfusion for IkB[unreadable], nuclear p50, and phosphorylation of mitogen activated protein kinases (MAPKs - ERK, p38, JNK);at 3h post reperfusion for RT-PCR to quantify lung tissue mRNA ..
  5. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2010
    ..Our studies may indicate that a common stool bacterium is oncogenic and contributes to colon cancer risk. If so, these data will lead to new public health approaches to the prevention of colon cancer. ..
  6. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    ..In addition, understanding the significance of the presence of bacteria in lungs being considered for donation may have serious implications on donor organ utilization. ..
  7. cGMP-dependent Protein Kinase Function in Osteoblast Mechanotransduction
    Renate B Pilz; Fiscal Year: 2013
    ..These studies will provide the foundation for novel and improved treatment strategies in osteoporosis. ..
  8. Chemical approaches for studying the biology of CD38
    Hening Lin; Fiscal Year: 2013
    ..Our proposed study will help to understand the roles of CD38 plays in normal and pathological conditions, and potentially lead to new ways to treat human diseases involving CD38. ..
  9. Regulation of Ovarian Cancer Multidrug Resistance by MAP Kinases
    Scott T Eblen; Fiscal Year: 2013
    ..Elucidation of this synergistic mechanism of drug resistance would provide important information for treating drug-resistant ovarian cancer. ..
  10. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..Induction of cytokines and their signaling pathways including mitogen activated protein kinases (MAPK) in blood and CSF will be correlated with changes in DA metabolism and behavior...
  11. Eicosanoids and Endothelial Cell Dysfunction
    Gadiparthi N Rao; Fiscal Year: 2013
    ....
  12. Mechanisms of Hormonal Regulation of the Sodium Chloride Cotransporter
    Robert S Hoover; Fiscal Year: 2013
    ..This investigation of the hormonal regulation of this key effector of blood pressure will provide invaluable insight into the pathogenesis of Hypertension. ..
  13. Mitogen-activated Protein Kinases and NF-kB Activation in Vascular Smooth Muscle
    Bingbing Jiang; Fiscal Year: 2010
    ....
  14. HIV-1 regulation by MTb: pathogen and host factor
    Anne Goldfeld; Fiscal Year: 2010
    ..abstract_text> ..
  15. Cardiomyocyte Apoptosis and Cardioprotective Actions of Estrogen
    Jin Kyung Kim; Fiscal Year: 2013
    ....
  16. Role of ERK1/2 in Neuromuscular Synapses and Myofiber Development in vivo
    Mendell Rimer; Fiscal Year: 2013
    ..Extracellular-signal regulated kinases 1 and 2 (ERK1/2) are the prototypical intracellular mitogen activated protein kinases (MAPK). ERK1/2 are activated by multiple growth factors and cytokines in many cell types...
  17. Structural and Functional Studies of the Novel DBD Domain of MKP5
    Amjad Farooq; Fiscal Year: 2012
    ..Our studies will set out to understand how MKP5 executes such a remarkable feat and how we can exploit this new knowledge to design novel drugs with less toxicity but more effectiveness for the treatment of cancer. ..
  18. Carbon Monoxide Therapy to Prevent Circulatory Collapse and Shock From Hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..Studies investigating the mechanisms of action of CO will be executed, focusing on mitogen activated protein kinases. Together, these studies will further our understanding of hemorrhagic shock and have great ..
  19. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    Timothy P Yoshino; Fiscal Year: 2013
    ..Therefore, knowledge gained from the proposed studies could very well lead to the development of more effective and novel methods for controlling human schistosome transmission by disrupting parasite development within the snail host. ..
  20. PROTEOLYSIS OF HMW FGF-2 BY THROMBIN AND ITS CARDIOVASCULAR IMPLICATIONS
    Giuseppe Pintucci; Fiscal Year: 2010
    ..The elucidation of these mechanisms will foster the development of new pharmacological tools for the treatment of the cardiovascular disorders associated with these diseases. ..
  21. BRP-39/YKL-40 in Th2 Inflammation and Asthma
    Jack A Elias; Fiscal Year: 2013
    ..They also demonstrate that BRP-39/YKL-40 binds to IL-13 receptor (R)a2 and activates mitogen activated protein kinases (MAPK) and PKB/Akt via an IL-13Ra2- dependent mechanism...
  22. Effect of ESAT-6 on human T cell Function
    Buka Samten; Fiscal Year: 2010
    ..This proposal seeks to understand the mechanisms by which ESAT-6 inhibits human T-cell immune function, information that is critical for development of improved vaccines and treatment strategies for tuberculosis. ..
  23. Central actions of angiotensin II in the control of fluid balance
    Daniel K Yee; Fiscal Year: 2013
    ..recognized to be linked to activation nontraditional signaling pathways, including activation of mitogen activated protein kinases (MAPK)...
  24. Airway Inflammatory Pathways Regulating Glucocorticoid Receptor Phosphorylation
    Omar Tliba; Fiscal Year: 2013
    ..This integrated translational approach is expected to advance our understanding of the cellular and molecular mechanisms that contribute to the development of steroid insensitivity in severe asthmatic patients. ..
  25. REGULATION OF THE SENSITIVITY OF DOPAMINE RECEPTORS
    KIM ARTHUR NEVE; Fiscal Year: 2013
    ..Analysis of wild type and mutant dopamine receptors expressed in mammalian cell lines, in neurons, and in vivo offers powerful model systems with which to perform basic research with important clinical implications. ..
  26. Group V Phospholipase A2 and Pulmonary Inflammation
    Howard R Katz; Fiscal Year: 2012
    ..They will provide new information on the function of this enzyme, which is presently poorly understood. These studies will provide new insight into the regulation of pulmonary inflammation and innate immunity. ..
  27. Interactions Between p90 Ribosomal S6 Kinase and Protein Kinase A
    Tarun B Patel; Fiscal Year: 2010
    The p90 Ribosomal S6 kinases (RSKs) are immediately downstream effectors of mitogen activated protein kinases and play a major role in regulation of cell proliferation and survival...
  28. Trauma-Induced Astrocyte Swelling/Brain Edema: Role of NKCC
    MICHAEL DAVID NORENBERG; Fiscal Year: 2013
    ....
  29. MLK3 inhibition protects the murine CNS from the effects of HIV-1 Tat
    Daniel F Marker; Fiscal Year: 2012
    ....
  30. STUDIES IN GASTROINTESTINAL ENDOCRINOLOGY
    Mark R Hellmich; Fiscal Year: 2010
    ..We have addressed the concerns raised in the summary statement of our prior application, and we have continued to demonstrate the productivity of our collaborating efforts. ..
  31. METASTATIC PROSTATE CANCER-INDUCED BONE PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2013
    ..If correct, data from this project may fundamentally change our understanding and treatment of prostate cancer-induced bone pain. ..
  32. Role of autophagy on the modulation of CYP2E1 alcohol liver toxicity
    Arthur I Cederbaum; Fiscal Year: 2013
    ..oxidant stress, levels and activity of CYP2E1, mitochondrial dysfunction, steatosis, activation of mitogen activated protein kinases, hepatoprotective defense, autophagy and autophagy regulators such as Bcl-2, AMPK, mTOR...
  33. Mechanism, regulation and function of PP2A ubiquitination
    Brian E Wadzinski; Fiscal Year: 2010
    ..abstract_text> ..
  34. INSULIN-REGULATED MAP KINASE PATHWAYS
    Melanie H Cobb; Fiscal Year: 2013
    ..The experiments proposed will determine mechanisms underlying ligand/process specificity in the ERK1/2 pathway. ..
  35. A molecular basis for endotoxin mediated insulin resistance
    SOPHIE HUSSEY; Fiscal Year: 2013
    ..signaling pathways regulated by this receptor [inhibitor ?B kinase IKK-nuclear factor-?B (?F??) and mitogen activated protein kinases (MAPKs)] have been implicated in the pathogenesis of insulin resistance...
  36. Conjugated linoleic acid (CLA) promotes inflammation in human adipocytes
    KRISTINA BROOKE MARTINEZ; Fiscal Year: 2010
    ..CLA mediates these effects through activating activator protein (AP)-1 via upstream activation of mitogen activated protein kinases (MAPKs)...
  37. New molecular techniques for T. cruzi
    Huan Huang; Fiscal Year: 2013
    ..cruzi life cycle stages. Using this technique, we found that two mitogen activated protein kinases (MAPK), TcMAPK1 and TcMAPK3, are essential for T. cruzi...
  38. The role of mitogen-activated protein kinase phosphatase-1 in tumor progression
    Xiaoyi Zhang; Fiscal Year: 2013
    ..This proposed research project provides necessary mechanistic insight into the function of innate immune regulator MKP-1 in the tumor microenvironment. ..
  39. Combinatorial Approach for Reducing Invasive Potential of Melanoma Cells
    Farrukh Afaq; Fiscal Year: 2013
    ..Studies have demonstrated that the majority of human melanomas have constitutively active mitogen activated protein kinases (MAPK) through oncogenic mutation in either BRAF or NRAS...
  40. The Effects of Alcohol on JNK Mediated Inflammatory Signaling in Glial Cells
    Jack L Leonard; Fiscal Year: 2013
    ..by toll-like receptors and up-regulates the secretion of inflammatory mediators regulated by mitogen activated protein kinases (MAPK);the consequence is a chronic increase in release of proinflammatory mediators...
  41. MECHANICAL INJURY OF THE ALVEOLAR EPITHELIUM
    SUSAN SHEPS MARGULIES; Fiscal Year: 2010
    ....
  42. Evolution of Dendritic Cell Dysfunction in FIV Infection
    TRACY L WEBB; Fiscal Year: 2012
    ..interferon regulatory factor, and transcriptional regulator production and activation of the mitogen activated protein kinases ERK and p38...
  43. DUSP1 as a therapeutic target in fibroproliferative acute lung injury
    David W Riches; Fiscal Year: 2013
    ..In addition, DUSP1 may also be a valid therapeutic target in other fibrotic lung disease, e.g. progressive pulmonary fibrosis. ..
  44. Regulation of MAPK Activity by EGFR Endocytosis
    Emilia Galperin; Fiscal Year: 2012
    ..abstract_text> ..
  45. G Protein signaling at the endosome
    Henrik G Dohlman; Fiscal Year: 2013
    ..Receptors of this class transmit signals to a variety of effector enzymes including mitogen activated protein kinases (MAPKs). This proposal is focused on the regulation of two MAPKs in yeast, Fus3 and Kss1...
  46. RGS12 as a MAPK Scaffold in Muscle Development and Disease
    EMILY ANNE OESTREICH; Fiscal Year: 2012
    ..We also hope to highlight the RGS12 scaffold as a point of therapeutic intervention in metastatic rhabdomyosarcoma, a satellite cell-derived cancer where H-Ras mutations and increased ERK activity have been described. ..
  47. Chlamydial modulation of Eukaryotic signaling pathways
    Robert J Bastidas; Fiscal Year: 2012
    ..These inflammatory responses are mediated by mitogen activated protein kinases (MAPK) ERK and NF-kB signaling pathways...
  48. Preventive Analgesia for Bone Cancer Pain
    PATRICK WILLIAM MANTYH; Fiscal Year: 2013
    ..If correct, data generated from this project has the potential to fundamentally change our understanding of the mechanisms that drive bone cancer pain and promote the use of preventive analgesia for managing bone cancer pain. ..
  49. ERK Mitogen Activated Protein Kinases in Skeletogenesis
    Edward M Greenfield; Fiscal Year: 2012
    The ERK mitogen activated protein kinases (MAPK) pathway has been implicated in a number of skeletal disorders...
  50. "Mixtures of Xenoestrogens Alter Estradiol-induced Non-Genomic Signaling"
    René Viñas; Fiscal Year: 2013
    ..abstract_text> ..
  51. Controlling the Source of Inflammatory Signaling in a Burn Model
    Saman Arbabi; Fiscal Year: 2012
    ..This topical treatment is easy to apply and can be initiated early post injury, even at the scene. ..
  52. EXERCISE AS A MEANS OF ENHANCING IMMUNITY IN THE AGED
    Jeffrey Woods; Fiscal Year: 2001
    ..for this effect by measuring Mphi IFN-gamma and LPS (CD14) receptor density and signaling through mitogen activated protein kinases (MAPK's). We will also measure P. acnes-induced IFN-gamma production...
  53. Integration of TNF Signaling in Apoptosis
    Anning Lin; Fiscal Year: 2010
    ..abstract_text> ..
  54. METABLASTIN AND THE CONTROL OF CELL DIVISION
    ULRICH SCHUBART; Fiscal Year: 1999
    ..The proposed studies promise to shed light on a novel mechanism in the control cell replication, perturbations of which may play a role in oncogenesis. ..
  55. Mechanisms of Trichothecene Toxicity
    James Pestka; Fiscal Year: 2005
    ..abstract_text> ..
  56. SWELLING ACTIVATED CURRENTS AND MYOCYTE VOLUME IN CHF
    CLIVE BAUMGARTEN; Fiscal Year: 2004
    ..Further, this work may lead to new approaches to treat or prevent CHF and thereby, reduce the morbidity and mortality of this common disease. ..
  57. Molecular Mechanisms of Phenolic Agent-induced Apoptosis
    Ah Ng Kong; Fiscal Year: 2006
    ..Such knowledge will help to develop better chemopreventive compounds and to design more effective cancer chemoprevention clinical trials. ..
  58. Spatial compartmentalization of Ras-MAPK signaling by KSR1 in neurons
    ERZSEBET MARIA SZATMARI; Fiscal Year: 2010
    ..the signaling pathway involving Ras and extracellular signal-regulated kinase (ERK), a member of the mitogen activated protein kinases (MARK)...
  59. NF-kappaB Signaling Networks in I/R and Late PC
    W Jones; Fiscal Year: 2007
    ..abstract_text> ..
  60. 'Death' and 'MAPK' pathways with myocardial ischemia
    Junichi Sadoshima; Fiscal Year: 2001
    ..Myocardial I/R activates stress-responsive mitogen activated protein kinases (SR-MAPKs), including iNKs and p38-MAPKS...
  61. MOLECULAR SIGNALING BY OXIDANT STRESS IN LUNG EPITHELIUM
    Brooke Mossman; Fiscal Year: 2000
    ....
  62. Protein-protein interaction domains: targets for neuropharmacologic intervention
    KEVIN CALDWELL; Fiscal Year: 2007
    ..Thus, these studies will have significant impact on several research fields, including neurobiology, cell biology, biochemistry, and cancer biology. [unreadable] [unreadable]..
  63. IFN AND ANTIPROLIFERATIVE SIGNALING PATHWAYS
    Andrew Larner; Fiscal Year: 2002
    ..Stat4 are phosphorylated on a conserved serine residue which is a consensus phosphorylation site for mitogen activated protein kinases (MAPK)...
  64. CHARACTERIZATION OF A NOVEL MAP/ERK KINASE
    Marsha Rosner; Fiscal Year: 2004
    ..abstract_text> ..