guanylate cyclase

Summary

Summary: An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.

Top Publications

  1. pmc Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain
    Ralf Paul
    Division of Molecular Microbiology, Biozentrum, University of Basel, 4056 Basel, Switzerland
    Genes Dev 18:715-27. 2004
  2. ncbi Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
    Georg Lenz
    Metabolism Branch, Division of Cancer Treatment and Diagnosis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Science 319:1676-9. 2008
  3. pmc Long-term preservation of cone photoreceptors and restoration of cone function by gene therapy in the guanylate cyclase-1 knockout (GC1KO) mouse
    Sanford L Boye
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Invest Ophthalmol Vis Sci 52:7098-108. 2011
  4. pmc Murine guanylate cyclase C regulates colonic injury and inflammation
    Kris A Steinbrecher
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 186:7205-14. 2011
  5. ncbi High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation
    Eva Jebelovszki
    Second Department of Medicine and Center of Cardiology, University of Szeged, Szeged
    Am J Physiol Heart Circ Physiol 294:H2558-64. 2008
  6. pmc Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases
    Manuel Zimmer
    Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA
    Neuron 61:865-79. 2009
  7. ncbi Ca(2+)-modulated vision-linked ROS-GC guanylate cyclase transduction machinery
    Karl W Koch
    AG Biochemistry, IBU, Faculty V, Carl von Ossietzky University, Oldenburg 26111, Germany
    Mol Cell Biochem 334:105-15. 2010
  8. pmc Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    Johannes Peter Stasch
    Institute of Cardiovascular Research, Bayer HealthCare, Wuppertal, Germany
    J Clin Invest 116:2552-61. 2006
  9. pmc CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1
    Donghai Wang
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    Mol Cell Biol 24:164-71. 2004
  10. pmc The phytosulfokine (PSK) receptor is capable of guanylate cyclase activity and enabling cyclic GMP-dependent signaling in plants
    Lusisizwe Kwezi
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, Victoria 3052, Australia
    J Biol Chem 286:22580-8. 2011

Detail Information

Publications326 found, 100 shown here

  1. pmc Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain
    Ralf Paul
    Division of Molecular Microbiology, Biozentrum, University of Basel, 4056 Basel, Switzerland
    Genes Dev 18:715-27. 2004
    ..Targeting of PleD to the cell pole is coupled to the activation of a C-terminal guanylate cyclase domain, which catalyzes the synthesis of cyclic di-guanosine monophosphate...
  2. ncbi Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
    Georg Lenz
    Metabolism Branch, Division of Cancer Treatment and Diagnosis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Science 319:1676-9. 2008
    ..These results demonstrate that CARD11 is a bona fide oncogenein DLBCL, providing a genetic rationale for the development of pharmacological inhibitors of the CARD11 pathway for DLBCL therapy...
  3. pmc Long-term preservation of cone photoreceptors and restoration of cone function by gene therapy in the guanylate cyclase-1 knockout (GC1KO) mouse
    Sanford L Boye
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Invest Ophthalmol Vis Sci 52:7098-108. 2011
    The authors previously showed that subretinal delivery of AAV5 vectors containing murine guanylate cyclase-1 (GC1) cDNA driven by either photoreceptor-specific (hGRK1) or ubiquitous (smCBA) promoters was capable of restoring cone-..
  4. pmc Murine guanylate cyclase C regulates colonic injury and inflammation
    Kris A Steinbrecher
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 186:7205-14. 2011
    b>Guanylate cyclase C (GUCY2C or GC-C) and its ligands, guanylin (GUCA2A or Gn) and uroguanylin (GUCA2B or Ugn), are expressed in intestinal epithelial cells and regulate ion secretion, intestinal barrier function, and epithelial monolayer ..
  5. ncbi High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation
    Eva Jebelovszki
    Second Department of Medicine and Center of Cardiology, University of Szeged, Szeged
    Am J Physiol Heart Circ Physiol 294:H2558-64. 2008
    ..The presence of the soluble guanylate cyclase (sGC) inhibitor oxadiazolo-quinoxaline (ODQ) elicited a similar reduction in ACh-induced dilations in the ..
  6. pmc Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases
    Manuel Zimmer
    Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA
    Neuron 61:865-79. 2009
    ..Both sGC expression and cell-intrinsic dynamics contribute to the differential roles of URX and BAG in O2-dependent behaviors...
  7. ncbi Ca(2+)-modulated vision-linked ROS-GC guanylate cyclase transduction machinery
    Karl W Koch
    AG Biochemistry, IBU, Faculty V, Carl von Ossietzky University, Oldenburg 26111, Germany
    Mol Cell Biochem 334:105-15. 2010
    ..of both is reciprocally regulated including the dynamic synthesis of cyclic GMP by a membrane bound guanylate cyclase. Different from hormone receptor guanylate cyclases, the cyclases operating in phototransduction are ..
  8. pmc Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    Johannes Peter Stasch
    Institute of Cardiovascular Research, Bayer HealthCare, Wuppertal, Germany
    J Clin Invest 116:2552-61. 2006
    ....
  9. pmc CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1
    Donghai Wang
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    Mol Cell Biol 24:164-71. 2004
    ..Together, these results indicate that CARMA1 mediates CD3/CD28 costimulation-induced NF-kappaB activation by recruiting downstream signaling components into the immunological synapse...
  10. pmc The phytosulfokine (PSK) receptor is capable of guanylate cyclase activity and enabling cyclic GMP-dependent signaling in plants
    Lusisizwe Kwezi
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, Victoria 3052, Australia
    J Biol Chem 286:22580-8. 2011
    ..We identified a putative guanylate cyclase (GC) catalytic center in PSKR1 that is embedded within the kinase domain and hypothesized that the GC works ..
  11. ncbi PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation
    Ki Young Lee
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 308:114-8. 2005
    ..Hence, PDK1 plays a critical role by nucleating the TCR-induced NF-kappaB activation pathway in T cells...
  12. pmc Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors
    Igor V Peshenko
    Department of Basic Sciences and Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania 19027, USA
    Biochemistry 50:5590-600. 2011
    ....
  13. pmc Ca(2+) sensor S100beta-modulated sites of membrane guanylate cyclase in the photoreceptor-bipolar synapse
    Teresa Duda
    The Unit of Regulatory and Molecular Biology, Departments of Cell Biology and Ophthalmology, NJMS and SOM UMDNJ, Stratford, NJ 08084, USA
    EMBO J 21:2547-56. 2002
    This study documents the identity of a calcium- regulated membrane guanylate cyclase transduction system in the photoreceptor-bipolar synaptic region...
  14. ncbi Pharmacological activation of soluble guanylate cyclase protects the heart against ischemic injury
    Sevil Korkmaz
    Department of Cardiac Surgery, University of Heidelberg, Germany
    Circulation 120:677-86. 2009
    ..The novel soluble guanylate cyclase activator cinaciguat has been reported to elevate intracellular [cGMP] and activate the nitric oxide/cGMP/..
  15. pmc The anti-aggregating effect of BAY 41-2272, a stimulator of soluble guanylyl cyclase, requires the presence of nitric oxide
    Séverine Roger
    Département Angiologie, Institut de Recherches Servier, 11 rue des Moulineaux, Suresnes, France
    Br J Pharmacol 161:1044-58. 2010
    ..The purpose of the present study was to determine whether a stimulator of soluble guanylyl cyclase, BAY 41-2272, inhibits platelet aggregation and to clarify its interaction with nitric oxide (NO)...
  16. pmc RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells
    Seifollah Azadi
    Department of Biochemistry and Molecular Biology, Centre for Macular Research, University of British Columbia, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 107:21158-63. 2010
    ..photoreceptor degeneration in the rd3 mouse, rcd2 dog, and LCA12 patients is caused by impaired RD3-mediated guanylate cyclase expression and trafficking...
  17. pmc The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways
    Chintamani N Joshi
    Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    J Pharmacol Exp Ther 339:394-402. 2011
    ..The present work analyzed the effects of the soluble guanylate cyclase (sGC) stimulator 3-(4-amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine [BAY ..
  18. ncbi NO-independent regulatory site on soluble guanylate cyclase
    J P Stasch
    Pharma Research Center, Bayer AG, Aprather Wey 18a, D 42096 Wuppertal, Germany
    Nature 410:212-5. 2001
    ..to NO; mammalian cells synthesize NO; and last, NO mediates vasodilatation by stimulating the soluble guanylate cyclase (sGC), a heterodimeric (alpha/beta) haem protein that converts GTP to cGMP2-4...
  19. pmc NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
    Oleg V Evgenov
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, CLN 309, Boston, Massachusetts 02114, USA
    Nat Rev Drug Discov 5:755-68. 2006
    Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO)...
  20. ncbi Experience-dependent modulation of C. elegans behavior by ambient oxygen
    Benny H H Cheung
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Curr Biol 15:905-17. 2005
    ..In C. elegans, an atypical O2 binding soluble guanylate cyclase (sGC), GCY-35, regulates O2 responses...
  21. pmc Ca2+ signaling by plant Arabidopsis thaliana Pep peptides depends on AtPepR1, a receptor with guanylyl cyclase activity, and cGMP-activated Ca2+ channels
    Zhi Qi
    College of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010021, China
    Proc Natl Acad Sci U S A 107:21193-8. 2010
    ..The signaling cascade initiated by AtPeps leads to expression of pathogen-defense genes in a Ca(2+)-dependent manner...
  22. ncbi Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
    R T Schermuly
    University of Giessen Lung Centre, Giessen, Germany
    Eur Respir J 32:881-91. 2008
    Alterations of the nitric oxide receptor, soluble guanylate cyclase (sGC) may contribute to the pathophysiology of pulmonary arterial hypertension (PAH)...
  23. ncbi Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study
    H A Ghofrani
    Dept of Internal Medicine, Medical Clinic II V, University Hospital Giessen and Marburg GmbH, Klinikstrasse 36, 35392 Giessen, Germany
    Eur Respir J 36:792-9. 2010
    We assessed the therapeutic potential of riociguat, a novel soluble guanylate cyclase stimulator, in adults with chronic thromboembolic pulmonary hypertension (CTEPH; n = 42) or pulmonary arterial hypertension (PAH; n = 33) in World ..
  24. ncbi Guanylyl cyclase-activating proteins (GCAPs) are Ca2+/Mg2+ sensors: implications for photoreceptor guanylyl cyclase (RetGC) regulation in mammalian photoreceptors
    Igor V Peshenko
    Hafter Research Laboratory, Pennsylvania College of Optometry, Elkins Park, Pennsylvania 19027
    J Biol Chem 279:16903-6. 2004
    ..While Ca(2+) binding is essential for cyclase activation and inhibition, Mg(2+) binding to GCAPs is critical for setting the actual dynamic range of RetGC regulation by GCAPs at physiological levels of free Ca(2+)...
  25. ncbi Soluble guanylate cyclases act in neurons exposed to the body fluid to promote C. elegans aggregation behavior
    Benny H H Cheung
    The Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 14:1105-11. 2004
    ..elegans to aggregate. Instead, these molecules may transduce one of several pathways that induce C. elegans to aggregate or may modulate aggregation by responding to cues in C. elegans body fluid...
  26. ncbi CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation
    Olivier Gaide
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 3:836-43. 2002
    ..Together, our data show that CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation and CD28 costimulation-dependent Jnk activation...
  27. ncbi Ca2+ and Mg2+ binding properties of GCAP-1. Evidence that Mg2+-bound form is the physiological activator of photoreceptor guanylyl cyclase
    Igor V Peshenko
    Hafter Research Laboratories, Pennsylvania College of Optometry, Elkins Park, Pennsylvania 19027, USA
    J Biol Chem 281:23830-41. 2006
    ..Our results demonstrate that Mg2+ regulates GCAP-1 not only by adjusting its Ca2+ sensitivity to the physiological conditions in photoreceptors but also by creating the conformation required for RetGC stimulation...
  28. ncbi Cloning, sequencing, and expression of a 24-kDa Ca(2+)-binding protein activating photoreceptor guanylyl cyclase
    A M Dizhoor
    Department of Biochemistry, University of Washington, Seattle 98195, USA
    J Biol Chem 270:25200-6. 1995
    ..These findings demonstrate that p24, like GCAP, imparts Ca2+ sensitivity to photoreceptor membrane guanylyl cyclase. We propose that p24 be referred to as GCAP-2 and that GCAP be referred to as GCAP-1...
  29. ncbi Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis
    Yingrui Wang
    Department of Nephrology and Center of Cardiovascular Research, Charite University Medicine Berlin, Charite Campus Mitte, Humboldt University, Berlin, Germany
    Kidney Int 68:47-61. 2005
    A critical role of soluble guanylate cyclase and nitric oxide-dependent cyclic 3',5'-guanosine monophosphate (cGMP) production for glomerular matrix expansion has recently been documented in a rat model of acute anti-thy1 ..
  30. pmc The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase
    Jonathan A Winger
    Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
    BMC Struct Biol 8:42. 2008
    ..The guanylate cyclase catalytic module, for which no structure has been determined at present, is a class III nucleotide cyclase ..
  31. pmc Crystal structures of the catalytic domain of human soluble guanylate cyclase
    Charles K Allerston
    Structural Genomics Consortium, University of Oxford, Oxford, The United Kingdom
    PLoS ONE 8:e57644. 2013
    Soluble guanylate cyclase (sGC) catalyses the synthesis of cyclic GMP in response to nitric oxide. The enzyme is a heterodimer of homologous α and β subunits, each of which is composed of multiple domains...
  32. ncbi Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation
    Kurt Schmidt
    Department of Pharmacology and Toxicology, Karl Franzens Universitat Graz, Graz, Austria
    Mol Pharmacol 82:420-7. 2012
    ..GTN) or 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxaline-1-one (ODQ) resulted in heme oxidation of soluble guanylate cyclase (sGC), as evident from diminished NO-induced cGMP accumulation that was paralleled by increased cGMP ..
  33. ncbi The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat
    - van Staveren WC
    Maastricht University, Department of Psychiatry and Neuropsychology, Universiteitssingel 50, POB 616, 6200 MD, Maastricht, The Netherlands
    Brain Res 888:275-286. 2001
    ..The results suggest an interaction between cGMP and cAMP signalling pathways in astrocytes of the rat hippocampus...
  34. ncbi Methylene blue for the treatment of septic shock
    Christopher A Paciullo
    Department of Pharmaceutical Services, Emory University Hospital, Atlanta, Georgia 30322, USA
    Pharmacotherapy 30:702-15. 2010
    ..Methylene blue is a selective inhibitor of guanylate cyclase, a second messenger involved in nitric oxide-mediated vasodilation...
  35. ncbi Allosteric regulation of nucleotidyl cyclases: an emerging pharmacological target
    Roland Seifert
    Institute of Pharmacology, Hannover Medical School, Hannover, Germany
    Sci Signal 5:pe37. 2012
    ..Here, we summarize the current status of such research and discuss future directions in this exciting field...
  36. pmc Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency
    Marija Mihelec
    Department of Genetics, University College London, Institute of Ophthalmology, London, United Kingdom
    Hum Gene Ther 22:1179-90. 2011
    ..Human GUCY2D and mouse Gucy2e genes encode guanylate cyclase-1 (GC1), which is responsible for restoring the dark state in photoreceptors after light exposure...
  37. ncbi The function of NO-sensitive guanylyl cyclase: what we can learn from genetic mouse models
    Andreas Friebe
    Physiologisches Institut I, Universitat Wurzburg, Röntgenring 9, 97070 Wurzburg, Germany
    Nitric Oxide 21:149-56. 2009
    ..As cell- and tissue-specific knock-out models are beginning to emerge, a more detailed analysis of the importance of the NO receptor in specific tissues will become possible...
  38. ncbi Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways
    Chung Soo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, South Korea
    Eur J Pharmacol 683:54-62. 2012
    ..The combination of licochalcone A and YC-1 may confer a benefit in the treatment of human epithelial ovarian adenocarcinoma...
  39. ncbi Structure and regulation of soluble guanylate cyclase
    Emily R Derbyshire
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Biochem 81:533-59. 2012
    ..to the cyclic guanosine monophosphate (cGMP) pathway as it functions as the primary activator of soluble guanylate cyclase (sGC). NO is synthesized from l-arginine and oxygen (O(2)) by the enzyme nitric oxide synthase (NOS)...
  40. ncbi Soluble guanylate cyclase
    Thomas L Poulos
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697 3900, USA
    Curr Opin Struct Biol 16:736-43. 2006
    Soluble guanylate cyclase (sGC) is a mammalian nitric oxide (NO) sensor. When NO binds to the sGC heme, its GTP cyclase activity markedly increases, thus generating cyclic GMP, which serves to regulate several cell signaling functions...
  41. ncbi The Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice
    Elena V Olshevskaya
    Hafter Research Laboratories, Pennsylvania College of Optometry, Elkins Park, Pennsylvania 19027, USA
    J Neurosci 24:6078-85. 2004
    ..These results provide the first direct evidence that a mutation linked to congenital blindness increases Ca2+ in the outer segment, which may trigger the apoptotic process...
  42. pmc KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels
    Bin Nan Wu
    Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Br J Pharmacol 142:1105-14. 2004
    ..induced by KMUP-1 was attenuated by epithelium removal and by pretreatment with inhibitors of soluble guanylate cyclase (sGC) (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), 1 microm), nitric oxide synthase (Nomega-nitro-L-..
  43. pmc Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms
    E Wang
    Anesthesia Center for Critical Care Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 114:603-13. 2011
    ..pathways involving myeloid differentiation factor 88 (MyD88), TIR-domain-containing adaptor protein-inducing interferon-β-mediated transcription factor (Trif), inducible nitric oxide synthase (iNOS), and soluble guanylate cyclase (sGC).
  44. ncbi Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease
    Guido Boerrigter
    Cardiorenal Research Laboratory, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cardiovasc Drug Rev 25:30-45. 2007
    The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5'-guanosine monophosphate (cGMP) pathway plays an important role in cardiovascular regulation by promoting vasodilation and inhibiting vascular smooth muscle cell growth, ..
  45. ncbi Methylene blue for vasoplegic syndrome treatment in heart surgery: fifteen years of questions, answers, doubts and certainties
    Paulo Roberto Barbosa Evora
    Head of the Surgery and Anatomy Department, Ribeirão Preto Medical School USP, Brazil
    Rev Bras Cir Cardiovasc 24:279-88. 2009
    There is strong evidence that methylene blue (MB), an inhibitor of guanylate cyclase, is an excellent therapeutic option for vasoplegic syndrome (VS) treatment in heart surgery...
  46. ncbi Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO* and beyond
    Rebecca H Ritchie
    Heart Failure Pharmacology, Baker IDI Heart and Diabetes Institute Melbourne, Victoria, Australia
    Pharmacol Ther 124:279-300. 2009
    ..Further impact of cGMP within the cardiovascular system is also discussed with a view to representing cGMP-based therapies as innovative pharmacotherapy, alone or concurrent with standard care, for the management of LVH...
  47. ncbi The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress
    Gayle Overend
    Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, Scotland, UK
    Peptides 34:209-18. 2012
    ..Thus, the principal-cell localized NPLP1-VQQ/Gyc76C cGMP pathway acts to signal environmental (salt) stress to the whole organism...
  48. ncbi Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS
    D Li
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Physiol Lung Cell Mol Physiol 281:L369-76. 2001
    Hypoxia upregulates endothelial (e) nitric oxide synthase (NOS), but how eNOS affects soluble guanylate cyclase (sGC) protein expression in hypoxia-induced pulmonary hypertension is unknown...
  49. ncbi Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development
    Ferid Murad
    Brown Institute of Molecular Medicine, University of Texas Health Science Center, Houston, USA
    N Engl J Med 355:2003-11. 2006
  50. ncbi Antihypertrophic actions of the natriuretic peptides in adult rat cardiomyocytes: importance of cyclic GMP
    Anke C Rosenkranz
    Howard Florey Institute, C The University of Melbourne, Parkville, VIC 3010, Australia
    Cardiovasc Res 57:515-22. 2003
    ..However, whether this effect is retained in the adult phenotype or if other members of the natriuretic peptide family exhibit similar antihypertrophic properties, has not been elucidated...
  51. ncbi BAY 41-2272, a direct activator of soluble guanylate cyclase, reduces right ventricular hypertrophy and prevents pulmonary vascular remodeling during chronic hypoxia in neonatal rats
    Philippe Deruelle
    Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver, Colo, USA
    Biol Neonate 90:135-44. 2006
    ..BAY 41-2272 is a novel direct activator of soluble guanylate cyclase independent of nitric oxide, effective as an acute pulmonary vasodilator in an animal model of persistent ..
  52. pmc Heme oxygenase-1 deficiency leads to alteration of soluble guanylate cyclase redox regulation
    Allan W Jones
    Department of Medical Pharmacology, and Physiology, University of Missouri Columbia, Columbia, MO 65212, USA
    J Pharmacol Exp Ther 335:85-91. 2010
    ..SNP, an NO donor) and 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole [YC-1; acts directly on soluble guanylate cyclase (sGC)] led to further relaxation, yet the residual contraction remained 2 to 3 times higher in H(mox)1(-/-) ..
  53. pmc Picomolar nitric oxide signals from central neurons recorded using ultrasensitive detector cells
    Katherine C Wood
    Wolfson Institute for Biomedical Research, University College London, London WCIE 6BT, United Kingdom
    J Biol Chem 286:43172-81. 2011
    ....
  54. pmc Mg2+/Ca2+ cation binding cycle of guanylyl cyclase activating proteins (GCAPs): role in regulation of photoreceptor guanylyl cyclase
    Alexander M Dizhoor
    Department of Basic Sciences, Pennsylvania College of Optometry, Salus University, 8360 Old York Road, Elkins Park, PA 19027, USA
    Mol Cell Biochem 334:117-24. 2010
    ..The Mg(2+)/Ca(2+) exchange in GCAP1 and 2 operates within different range of intracellular Ca(2+) concentrations and provides a two-step activation of the cyclase during rod recovery...
  55. pmc Thalidomide attenuates nitric oxide-driven angiogenesis by interacting with soluble guanylyl cyclase
    Syamantak Majumder
    Vascular Biology Lab, AU KBC Research Centre, Anna University, Chennai, TN, India
    Br J Pharmacol 158:1720-34. 2009
    ..Nitric oxide (NO) promotes angiogenesis by activating endothelial cells. Thalidomide arrests angiogenesis by interacting with the NO pathway, but its putative targets are not known. Here, we have attempted to identify these targets...
  56. ncbi The calcium-sensor guanylate cyclase activating protein type 2 specific site in rod outer segment membrane guanylate cyclase type 1
    Teresa Duda
    Unit of Regulatory and Molecular Biology, Department of Cell Biology SOM and NJMS, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
    Biochemistry 44:7336-45. 2005
    The rod outer segment membrane guanylate cyclase type 1 (ROS-GC1), originally identified in the photoreceptor outer segments, is a member of the subfamily of Ca(2+)-modulated membrane guanylate cyclases...
  57. pmc A recurrent mutation in GUCY2D associated with autosomal dominant cone dystrophy in a Chinese family
    Xueshan Xiao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, China
    Mol Vis 17:3271-8. 2011
    ..To identify the genetic locus and mutation responsible for autosomal dominant cone dystrophy (adCOD) in a large Chinese family and to describe the phenotypes of the patients...
  58. ncbi Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein
    K Palczewski
    Department of Ophthalmology, University of Washington, Seattle 98195
    Neuron 13:395-404. 1994
    ....
  59. ncbi First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension
    F Grimminger
    Dept of Internal Medicine, University Hospital Giessen and Marburg, Giessen, Germany
    Eur Respir J 33:785-92. 2009
    ..Riociguat (BAY 63-2521; Bayer Healthcare AG, Wuppertal, Germany) acts directly on soluble guanylate cyclase, stimulating the enzyme and increasing sensitivity to low NO levels...
  60. ncbi Taming platelets with cyclic nucleotides
    U R Schwarz
    , , Josef-Schneider Str. 2, 97080, , Germany
    Biochem Pharmacol 62:1153-61. 2001
    ....
  61. ncbi Phenotype of autosomal dominant cone-rod dystrophy due to the R838C mutation of the GUCY2D gene encoding retinal guanylate cyclase-1
    M Smith
    Department of Ophthalmology, Torbay Hospital, Torquay, Devon, UK
    Eye (Lond) 21:1220-5. 2007
    To describe the phenotype of members of a large Caucasian British family affected by autosomal dominant cone-rod dystrophy due to an R838C mutation in the guanylate cyclase 2D (GUCY2D) gene encoding retinal guanylate cyclase-1 (RETGC-1).
  62. pmc C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog
    Jie Liu
    Life Sciences Institute, Department of Molecular and Integrative Physiology, and Neuroscience Program, University of Michigan, Ann Arbor, Michigan, USA
    Nat Neurosci 13:715-22. 2010
    ..Our results identify a phototransduction cascade in C. elegans and implicate the function of a 'taste receptor' in phototransduction...
  63. pmc Crystal structure of the guanylyl cyclase Cya2
    Annika Rauch
    Department of Physiological Chemistry, Ruhr University Bochum, Universitaetsstrasse 150, 44801 Bochum, Germany
    Proc Natl Acad Sci U S A 105:15720-5. 2008
    ..Furthermore, we find that substrate specificity stems from faster turnover of GTP, rather than different affinities for GTP and ATP, implying that the specificity-determining interactions are established after the binding step...
  64. pmc Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase
    Andreas Friebe
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Proc Natl Acad Sci U S A 104:7699-704. 2007
    ..Our knockout model completely disrupts the NO/cGMP signaling cascade and provides evidence for the unique role of NO-GC as NO receptor...
  65. ncbi Mutations in the GUCA1A gene involved in hereditary cone dystrophies impair calcium-mediated regulation of guanylate cyclase
    Veronique B D Kitiratschky
    Molecular Genetics Laboratory, Institute for Ophthalmic Research, Centre for Ophthalmology, University Tübingen, Tubingen, Germany
    Hum Mutat 30:E782-96. 2009
    The GUCA1A gene encodes the guanylate cyclase activating protein 1 (GCAP1) of mammalian rod and cone photoreceptor cells, which is involved in the Ca2+-dependent negative feedback regulation of membrane bound guanylate cyclases in the ..
  66. ncbi Mutations of CARD11 but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma
    Manuel Montesinos-Rongen
    Department of Neuropathology, University Hospital Cologne, 50924 Cologne, Germany
    Acta Neuropathol 120:529-35. 2010
    ....
  67. pmc Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex
    Br J Pharmacol 142:453-60. 2004
    ..3 Blockers of ATP-dependent potassium channels (glibenclamide) or guanylate cyclase activity (ODQ) considerably reduced CORM-3-dependent relaxation, confirming that potassium channels ..
  68. pmc Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux
    Cynthia F Bartels
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Am J Hum Genet 75:27-34. 2004
    The homodimeric transmembrane receptor natriuretic peptide receptor B (NPR-B [also known as guanylate cyclase B, GC-B, and GUC2B]; gene name NPR2) produces cytoplasmic cyclic GMP from GTP on binding its extracellular ligand, C-type ..
  69. pmc Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans
    Elissa A Hallem
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 108:254-9. 2011
    ..function of BAG neurons requires TAX-2/TAX-4 cyclic nucleotide-gated ion channels and the receptor-type guanylate cyclase GCY-9...
  70. ncbi Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase
    A M Dizhoor
    Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, USSR
    Science 251:915-8. 1991
    ..Activation of guanylate cyclase by light-induced depletion of cytosolic calcium is a key event in this recovery process...
  71. ncbi Mutations in the retinal guanylate cyclase (RETGC-1) gene in dominant cone-rod dystrophy
    R E Kelsell
    Department of Molecular Genetics, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK
    Hum Mol Genet 7:1179-84. 1998
    ..The retinal-specific guanylate cyclase gene (RETGC-1), which maps to within this genetic interval and previously was implicated in Leber's ..
  72. ncbi Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction
    W A Gorczyca
    Department of Ophthalmology, University of Washington, Seattle 98195
    J Biol Chem 270:22029-36. 1995
    ....
  73. pmc GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice
    Kim A Howes
    Department of Ophthalmology, Moran Eye Center, University of Utah Health Science Center, Salt Lake City, UT 84112 5330, USA
    EMBO J 21:1545-54. 2002
    ..Ca(2+) regulates the activity of guanylate cyclase (GC) and the synthesis of cGMP by acting on a GC-activating protein (GCAP)...
  74. ncbi Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue
    Jesse M Gray
    Howard Hughes Medical Institute and Department of Anatomy, The University of California, San Francisco, California 94143 0452, USA
    Nature 430:317-22. 2004
    ..elegans requires the sensory cGMP-gated channel tax-2/tax-4 and a specific soluble guanylate cyclase homologue, gcy-35...
  75. ncbi Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension
    Joachim Mittendorf
    Bayer Schering Pharma AG, Medicinal Chemistry Wuppertal, 42096 Wuppertal, Germany
    ChemMedChem 4:853-65. 2009
    Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). Impairments of the NO-sGC signaling pathway have been implicated in the pathogenesis of cardiovascular and other diseases...
  76. ncbi Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus
    Angela Neitz
    Department of Neurophysiology, Medical School, Ruhr University Bochum, Germany
    Eur J Neurosci 33:1611-21. 2011
    ..In summary, we unravel a presynaptic role of NO/cGMP most likely in glutamate release and propose that HCN channels act as effectors for cGMP...
  77. ncbi Guanylate cyclases and associated activator proteins in retinal disease
    David M Hunt
    UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Mol Cell Biochem 334:157-68. 2010
    Two isoforms of guanylate cyclase, GC1 and GC2 encoded by GUCY2D and GUCY2F, are responsible for the replenishment of cGMP in photoreceptors after exposure to light...
  78. ncbi Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efficiency and Ca(2+)-sensitivity
    Ji Young Hwang
    Institut für Biologische Informationsverarbeitung 1, Forschungszentrum Julich, Julich, Germany
    Eur J Biochem 270:3814-21. 2003
    In rod phototransduction, cyclic GMP synthesis by membrane bound guanylate cyclase ROS-GC1 is under Ca(2+)-dependent negative feedback control mediated by guanylate cyclase-activating proteins, GCAP-1 and GCAP-2...
  79. pmc Activation and inhibition of photoreceptor guanylyl cyclase by guanylyl cyclase activating protein 1 (GCAP-1): the functional role of Mg2+/Ca2+ exchange in EF-hand domains
    Igor V Peshenko
    Hafter Research Laboratories, Pennsylvania College of Optometry, Elkins Park, PA 19027, USA
    J Biol Chem 282:21645-52. 2007
    ....
  80. pmc A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration
    Koji M Nishiguchi
    Ocular Molecular Genetics Institute, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Invest Ophthalmol Vis Sci 45:3863-70. 2004
    To identify pathogenic mutations in the guanylate cyclase-activating protein 1 (GCAP1) and GCAP2 genes and to characterize the biochemical effect of mutation on guanylate cyclase (GC) stimulation.
  81. pmc The Arabidopsis thaliana brassinosteroid receptor (AtBRI1) contains a domain that functions as a guanylyl cyclase in vitro
    Lusisizwe Kwezi
    Department of Biotechnology, University of the Western Cape, Bellville, South Africa
    PLoS ONE 2:e449. 2007
    ..Cyclic GMP has been implicated in an increasing number of plant processes, including responses to abiotic stresses such as dehydration and salt, as well as hormones...
  82. pmc Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1
    Margot Thome
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cold Spring Harb Perspect Biol 2:a003004. 2010
    ..Here, we summarize these findings and give an outlook on interesting open issues that need to be addressed in the future...
  83. pmc An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation
    Zhiqiang Chen
    Department of Medicine and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:12159-64. 2005
    ..that bioconversion by mitochondria of clinically relevant concentrations of GTN results in activation of guanylate cyclase, production of cGMP, vasodilation in vitro, and lowered blood pressure in vivo, which are eliminated by ..
  84. pmc Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors
    A Mendez
    The Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles 90089 9112, USA
    Proc Natl Acad Sci U S A 98:9948-53. 2001
    ..One mechanism thought to participate in sensitivity adjustments is Ca(2+) regulation of guanylate cyclase (GC) by guanylate cyclase-activating proteins (GCAPs)...
  85. pmc Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation
    Kazuhiro Ishiguro
    Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cell Biol 26:5497-508. 2006
    ..These results provide a novel function for CaMKII in TCR signaling and CARMA1-induced NF-kappaB activation...
  86. pmc Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor
    L R Potter
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 18:2164-72. 1998
    ..We conclude that phosphorylation of the KHD is absolutely required for hormone-dependent activation of NPR-A...
  87. ncbi Constitutive activation of photoreceptor guanylate cyclase by Y99C mutant of GCAP-1. Possible role in causing human autosomal dominant cone degeneration
    A M Dizhoor
    Department of Ophthalmology Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 273:17311-4. 1998
    ..At Ca2+ concentrations below 100 nM, characteristic of light-adapted photoreceptors, guanylate cyclase-activating protein (GCAPs) activate RetGC, and at free Ca2+ concentrations above 500 nM, characteristic of ..
  88. pmc NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle
    Johannes Peter Stasch
    Institute of Cardiovascular Research, Bayer AG, Germany
    Br J Pharmacol 136:773-83. 2002
    ..7. This novel type of sGC activator is a valuable research tool and may offer a new approach for treating cardiovascular diseases...
  89. ncbi Identification of a novel Arabidopsis thaliana nitric oxide-binding molecule with guanylate cyclase activity in vitro
    Takalani Mulaudzi
    Department of Biotechnology, University of the Western Cape, Bellville, South Africa
    FEBS Lett 585:2693-7. 2011
    ....
  90. ncbi Dysregulation of the endothelial nitric oxide synthase-soluble guanylate cyclase pathway is normalized by insulin in the aorta of diabetic rat
    Michela Zanetti
    Department of Clinical, Morphological and Technological Sciences DSCMT, Clinica Medica, University of Trieste, Italy
    Atherosclerosis 181:69-73. 2005
    Antiatherogenic effects of nitric oxide (NO) are mediated by activation of soluble guanylate cyclase (sGC) and are impaired by diabetes in animals and humans...
  91. ncbi The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion
    Joseph C Ayoob
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:6639-49. 2004
    ..Our results support a model in which cGMP production by Gyc76C facilitates Sema-1a-plexin A-mediated defasciculation of motor axons, allowing for the generation of neuromuscular connectivity in the developing Drosophila embryo...
  92. ncbi The cloning of a Caenorhabditis elegans guanylyl cyclase and the construction of a ligand-sensitive mammalian/nematode chimeric receptor
    E J Baude
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 75235 9050, USA
    J Biol Chem 272:16035-9. 1997
    ..elegans that align closely with the catalytic domain of GCY-X1, and thus an equally large number of different regulatory ligands may exist...
  93. ncbi Regulation of nitric oxide-sensitive guanylyl cyclase
    Andreas Friebe
    Abteilung für Pharmakologie, Medizinische Fakultat, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Circ Res 93:96-105. 2003
    ..Finally, regulation of GC expression and a possible modulation of GC activity by other factors are discussed...
  94. ncbi Transmembrane guanylate cyclase in intestinal pathophysiology
    Kris A Steinbrecher
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Curr Opin Gastroenterol 27:139-45. 2011
    Production of cyclic guanosine monophosphate (cGMP) by guanylate cyclase is of critical importance to gastrointestinal physiology...
  95. pmc A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans
    D A Birnby
    Department of Genetics, University of Washington, Seattle, Washington 98195 7360, USA
    Genetics 155:85-104. 2000
    ..These results demonstrate that cGMP is a prominent second messenger in C. elegans chemosensory transduction and suggest a previously unknown role for Hsp90 in regulating cGMP levels...
  96. pmc Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice
    Emmanuel S Buys
    Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 122:2316-25. 2012
    ..Male mice deficient in a NO receptor component, the α1 subunit of soluble guanylate cyclase (sGCα1), are prone to hypertension in some, but not all, mouse strains, suggesting that additional genetic ..
  97. pmc PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
    Hisaaki Shinohara
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    J Exp Med 202:1423-31. 2005
    ..Hence, our data suggest that phosphorylation of CARMA1, mediated by PKCbeta, brings two key protein kinases, TAK1 and IKK, into close proximity, thereby allowing TAK1 to phosphorylate IKK...
  98. ncbi A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma
    Gehong Dong
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Clin Cancer Res 17:1440-51. 2011
    ..We investigated the genetic abnormalities of CARD11, A20, and ABIN-1/2/3 (the A20 binding inhibitor of NF-κB) and their clinicopathologic correlation in gastrointestinal DLBCL...
  99. pmc Effects of stimulation of soluble guanylate cyclase on diabetic nephropathy in diabetic eNOS knockout mice on top of angiotensin II receptor blockade
    Ina M Ott
    Institute for Nutritional Science, University of Potsdam, Potsdam, Germany
    PLoS ONE 7:e42623. 2012
    ..Novel approaches include the stimulation of soluble guanylate cyclase (sGC) as it is reported to have beneficial effects on cardiac and renal damage...
  100. pmc Functional and behavioral restoration of vision by gene therapy in the guanylate cyclase-1 (GC1) knockout mouse
    Shannon E Boye
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 5:e11306. 2010
    Recessive mutations in guanylate cyclase-1 (Gucy2d) are associated with severe, early onset Leber congenital amaurosis-1(LCA1)...
  101. ncbi Autosomal dominant cone and cone-rod dystrophy with mutations in the guanylate cyclase activator 1A gene-encoding guanylate cyclase activating protein-1
    S M Downes
    Moorsfield Eye Hospital, London, England
    Arch Ophthalmol 119:96-105. 2001
    To describe the phenotype in 3 families with dominantly inherited cone and cone-rod dystrophy with mutations in guanylate cyclase activator 1A (GUCA1A), the gene-encoding guanylate cyclase activator protein-1 (GCAP-1).

Research Grants62

  1. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..which encode proteins involved in proliferation (Neurofibromin 1) and apoptosis (Nore1, Fap1 and a soluble guanylate cyclase component)...
  2. Redox Regulation of Vascular cGMP Signaling in Neonatal Lungs
    Kathryn N Farrow; Fiscal Year: 2013
    ..Potential key targets for ROS-mediated dysregulation in the pulmonary vasculature are soluble guanylate cyclase (sGC) and phosphodiesterase 5 (PDE5)...
  3. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism
    Jeffrey A Kline; Fiscal Year: 2013
    ..In experimental PE, if guanylate cyclase is stimulated, the PVR can be normalized, and intracardiac hemolysis prevented...
  4. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2013
    ..Finally, cargo is assembled for intraflagellar transport. Based on our previous results with guanylate cyclase knockouts, we postulate that some peripheral membrane-associated proteins (PMPs) of the phototransduction ..
  5. Golgi-associated NO-cGMP Signaling Defect in Muscular Dystrophy
    Gail D Thomas; Fiscal Year: 2013
    ..Furthermore, we find that soluble guanylate cyclase (sGC), which is activated by NO, and cGMP-activated protein kinase G (PKG) are colocalized with nNOS2 on the ..
  6. Open Angle Glaucoma in Soluble Guanylate Cyclase Alpha 1 Deficient Mice
    Emmanuel S Buys; Fiscal Year: 2013
    ..Our preliminary data establish mice deficient in the nitric oxide (NO) receptor soluble guanylate cyclase ?1 (sGC??1 -/-) as a new animal model for OAG, and identify sGC??1 -/- mice as a unique model to study the ..
  7. Femtosecond Coherence Spectroscopy &Ultrafast Kinetic Study of Heme Proteins
    Paul M Champion; Fiscal Year: 2012
    ..and dynamics of heme proteins such as cytochrome P450, mammalian peroxidases, nitric oxide synthase, soluble guanylate cyclase, nitrophorin, and cytochrome c...
  8. CARDIOPROTECTIVE EFFECTS OF PDE-5 INHIBITORS
    Rakesh C Kukreja; Fiscal Year: 2013
    ..We will test the following new hypotheses: 1: Modulation of cGMP with PDE-5 inhibitors and novel soluble guanylate cyclase (sGC) activator protect against myocardial infarction, apoptosis, remodeling and insulin resistance in the ..
  9. Improving Outcomes in Cardiac Arrest/CPR with Inhaled Nitric Oxide
    Fumito Ichinose; Fiscal Year: 2013
    ..the salutary effect of inhaled NO on 10-day survival after CA/CPR was abolished in mice deficient in soluble guanylate cyclase (sGC), a NO receptor...
  10. NO-independent cGMP regulation of vascular remodeling
    David A Tulis; Fiscal Year: 2012
    ..Nitric oxide (NO) and carbon monoxide (CO) operate as soluble guanylate cyclase (sGC)-activating ligands for cGMP synthesis; however, limitations of NO and CO signaling warrant study into ..
  11. Genetic Mechanisms of Retinal Degenerative Disease
    JANIS LEM GEE; Fiscal Year: 2010
    ..However, low intracellular calcium can also stimulate guanylate cyclase activity to synthesize cGMP...
  12. Toward mechanism- and gene-based therapies for retinal degeneration
    Stephen H Tsang; Fiscal Year: 2012
    ..Aim 1. Establish if lower than normal PDE6 activity, combined with normal guanylate cyclase activity, results in elevated cGMP levels in Pde6bH620Qmutant mouse. Aim 2...
  13. Role of cGKII in AMPA Receptor Transport
    Edward B Ziff; Fiscal Year: 2013
    ..receptor through NMDAR activation of nNOS, leading to the production of nitric oxide, activation of soluble guanylate cyclase and production of cGMP, which induces cGKII. The Aims of this project are: Aim 1...
  14. Inhibition of NO Dependent Splanchnic Hyperemia Improves CFS/POTS
    ANTHONY JAMES OCON; Fiscal Year: 2012
    ..3) We will test the hypothesis that the guanylate cyclase inhibitor methylene blue versus phenylephrine differentially decreases splanchnic pooling in CFS/POTS ..
  15. Membrane-targeting calcium sensors in vision
    James B Ames; Fiscal Year: 2013
    ..Our studies will focus on retinal recoverin, involved in cancer-associated retinopathy;guanylate cyclase activating proteins (GCAPs);linked to autosomal dominant cone dystrophy;centrins, that control protein ..
  16. sGCa1-deficient mice: a novel murine model of elevated IOP and glaucoma
    Bruce R Ksander; Fiscal Year: 2012
    ..Our preliminary data show that mice deficient in the a1 subunit of soluble guanylate cyclase (sGCa1-/- mice) spontaneously develop high IOP and glaucoma, characterized by loss of RGC's...
  17. REGULATION OF CYCLIC GMP SYNTHESIS IN PHOTORECEPTORS
    Alexander M Dizhoor; Fiscal Year: 2013
    ..By completing these specific aims, we expect to overcome some critical barriers in understanding of RetGC regulation and its role in normal photoreceptor physiology and in retinal diseases. ..
  18. GC-C Agonists: Specific Probes for the Detection of Colorectal Tumors
    Kunwar Shailubhai; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Uroguanylin (UG) and guanylin (GN) are endogenous agonists of the guanylate cyclase C (GC-C) receptor that were discovered as natriuretic hormones based on their structural similarity to bacterial ..
  19. Nitrite and Hypoxia Increase Mitochondrial Biogenesis and Insulin Sensitivity
    CHRISTOPHER P O'DONNELL; Fiscal Year: 2013
    ..Furthermore, we will examine the contribution of the constitutive NO-soluble guanylate cyclase (sGC) pathway versus non-sGC pathways in mediating increases in insulin sensitivity and muscle glucose ..
  20. cGMP Metabolism in Resistance to Bacterial Infection
    Kris Steinbrecher; Fiscal Year: 2013
    ..and uroguanylin are peptides that are expressed at mucosal surfaces and bind to the transmembrane receptor guanylate cyclase C (GC-C)...
  21. S-Nitrosation in Nitric Oxide Signaling
    William R Montfort; Fiscal Year: 2010
    ..biochemical and molecular genetics investigations of three key proteins: thioredoxin, soluble guanylate cyclase and glutathione S-nitroso reductase (GSNOR)...
  22. Physiologic profiling of sGC genetic variants
    CHRISTOPHER HOLMES NEWTON-CHEH; Fiscal Year: 2013
    ..pressure was identified at the GUCY1A3/GUCY1B3 locus, which encodes the alpha1 and beta1 subunit of soluble guanylate cyclase, an enzyme which synthesizes cGMP when activated by nitric oxide and which is abundantly expressed in the ..
  23. Reconsolidation and extinction processes in the treatment of drug addiction
    Yossef Itzhak; Fiscal Year: 2010
    ..The second aim will test the hypothesis that inhibition of nNOS and soluble guanylate cyclase (sGC) impairs extinction of cocaine CPP...
  24. Mechanisms and Therapeutic Treatments for Inherited Retinal Degenerative Diseases
    Robert S Molday; Fiscal Year: 2013
    ..and Leber Congenital Amaurosis Type 12 (LCA12) linked to mutations in RD3, a novel protein essential for guanylate cyclase expression in photoreceptor cells...
  25. Epsilon-sarcoglycan in LGMD Type 2D
    Kevin Campbell; Fiscal Year: 2009
    ..Analysis of mouse models treated with nitric oxide-independent guanylate cyclase activators as well as genetic deletion of soluble guanylate cyclase and PDE5A will test this hypothesis...
  26. Theoretical Investigations of Interactions of Ligands with Various Hemoproteins
    John D Watts; Fiscal Year: 2011
    ..kinetic parameter for the binding of XO molecules (X = O, C, N) to Mb;(2) The ligand selectivity of soluble guanylate cyclase (sGC)-like heme domains;(3) The structure and energetics of the active intermediates in the catalytic cycle ..
  27. Mapping The Domain Architecture And Conformations of Soluble Guanylate Cyclase
    ERIC STEVEN UNDERBAKKE; Fiscal Year: 2012
    ..Soluble guanylate cyclase (sGC) is the primary receptor of NO...
  28. Endothelial dysfunction in the cerebral circulation
    Zvonimir S Katusic; Fiscal Year: 2013
    ..mice including eNOS, nNOS-, and iNOS-deficient mice, [unreadable]1 or [unreadable]1 isoform of soluble guanylate cyclase-deficient mice, and endothelial specific PPAR[unreadable]-defcient mice...
  29. HORMONAL REGULATION OF ENERGY METABOLISM
    Tarun Patel; Fiscal Year: 1993
    ..biological process which can attach significance to the presence of atriopeptin receptors and particulate guanylate cyclase in this tissue...
  30. Mechanism of Cone Degeneration Resulting from CNG Channel Deficiency
    Xi Qin Ding; Fiscal Year: 2013
    ..We will test the ability of guanylate cyclase (GC) inhibitors to reduce cone degeneration in the channel-deficient mice...
  31. Measurement of nitric-oxide-modified proteins by cavity ring-down spectroscopy
    Kevin K Lehmann; Fiscal Year: 2013
    ..Nitric oxide synthase products signal through interactions with heme centers in metalloproteins, such as guanylate cyclase and through covalent reactions with protein cysteine thiols...
  32. Intracelllar Pathways That Silence the Fetal Globin Gene
    Tohru Ikuta; Fiscal Year: 2006
    ..We recently showed that an intracellular pathway comprising soluble guanylate cyclase (sGC) and cGMP-dependent protein kinase (PKG) plays an important role in gamma-globin gene expression in ..
  33. BIOLOGY OF ATRIAL NATRIURETIC FACTOR AND ITS RECEPTORS
    Thomas Maack; Fiscal Year: 2000
    ..GCA receptors, mutants will be constructed with: i) truncations of the total intracellular, kinase-like and guanylate cyclase domains; and ii) deletion and substitutions of amino acids in the kinase domain that may determine its ..
  34. GC-C agonists for colitis-induced CRC
    Kunwar Shailubhai; Fiscal Year: 2009
    ..UG) and guanylin (GN) are peptide hormones produced in the lumen of the GI tract where they bind to Guanylate Cyclase C (GC-C), resulting in enhanced production of cyclic guanosine monophosphate (cGMP) and activation of cystic ..
  35. SECOND MESSENGER FUNCTION IN EXOCRINE GLANDS
    Thomas Hurley; Fiscal Year: 1993
    ..control second messenger concentration: high affinity CaATPase and active Ca2+ translocation, adenylate and guanylate cyclase activities and cAMP and cGMP phosphodiesterase activities; and (2) characterize the kinetic properties of ..
  36. MULTIPLE FORMS OF HEME OXYGENASE--REGULATION BY TOXINS
    MAHIN MAINES; Fiscal Year: 2001
    ..Hemoproteins, such as NO synthase, guanylate cyclase, cytochrome P450s, and others are vital to cellular functions...
  37. Nitric Oxide Signaling and Soluble Guanylate Cyclase
    Michael A Marletta; Fiscal Year: 2010
    ..Activation and deactivation of soluble guanylate cyclase (sGC) is of central importance in nitric oxide (NO) signaling...
  38. Cyclic Nucleotides and Fetal Globin Gene Expression
    Tohru Ikuta; Fiscal Year: 2004
    ..cells as well as in primary erythroblasts by activating an intracellular pathway comprising soluble guanylate cyclase (sGC) and cGMP-dependent protein kinase (PKG)...
  39. CONFORMATIONAL ASPECTS OF VISUAL EXCITATION
    LUBERT STRYER; Fiscal Year: 1993
    ..5) We have recently found that guanylate cyclase is activated by small decreases in the concentration of Ca2+ in the vicinity of 10-7 M...
  40. STRUCTURE AND FUNCTION OF THE E. COLI STB ENTEROTOXIN
    LAWRENCE DREYFUS; Fiscal Year: 2000
    ..STa is an 18- or 19-mer acidic peptide which binds to and activates guanylate cyclase C (GCC), a unique intestinal form of membrane guanylate cyclase...
  41. MECHANISMS UNDERLYING THE CIRCADIAN RHYTHM OF IOP
    Douglas Gregory; Fiscal Year: 1999
    ..receptor control of adenylate cyclase, (3) natriuretic peptide control of cGMP, and (4) soluble guanylate cyclase, nitric oxide synthase modulation of cGMP in control of the circadian rhythms of intraocular pressure and ..
  42. PATHOGENESIS OF DIARRHEA:PROTEIN KINASE C & SECRETAGOGUE
    CYNTHIA SEARS; Fiscal Year: 1993
    ..our studies demonstrate that PKC activation potentiates the physiologic and biochemical responses to the guanylate cyclase-activating heat stable enterotoxin of Escherichia coli (STa). The specific aims of this proposal are: I...
  43. Cloning, expression and purification of uroguanylin
    Kunwar Shailubhai; Fiscal Year: 2002
    ..Although the precise mechanism is still not clear, we believe UG binds to guanylate cyclase receptors (GC-C) and stimulates intracellular production of cyclic guanosine monophosphate (cGMP), resulting ..
  44. Agonists of guanylate cyclase receptor for colon cancer
    Kunwar Shailubhai; Fiscal Year: 2002
    ..Although the precise mechanism is still not clear, we believe uroguanylin binds to guanylate cyclase C (GC-C) and stimulates intracellular production of cyclic guanosine monophosphate (cGMP), resulting in ..
  45. ETHANOL, NITRIC OXIDE AND CORONARY HEART DISEASE
    EUGENE DEMASTER; Fiscal Year: 2002
    ..According to our mechanism, protection by ethanol occurs via an enhancement of the NO activation of guanylate cyclase by products of ethanol metabolism...
  46. AI ADENOSINE RECEPTOR IN CULTURED HEART CELLS
    Bruce Liang; Fiscal Year: 1993
    ..1) A1AR are coupled to the various potential effectors such as the adenylate cyclase, phosphodiesterase, guanylate cyclase or the potassium channel, and we will study the role of these potential effectors in mediating the ..
  47. EFFECTS OF PROSTAGLANDINS ON MYOMETRIAL METABOLISM
    CLARISSA BEATTY; Fiscal Year: 1980
    ..e., oxytocin, epinephrine, etc.) sensitivity of the enzymes involved in the synthesis (adenylate and guanylate cyclase) and degradation (cAMP- and cGMP-phosphodiesterase) of the cyclic nucleotides during the follicular and ..
  48. ANP RECEPTOR-MEDIATED OF FUNCTIONS IN GLOMERULAR CELLS
    BARBARA BALLERMANN; Fiscal Year: 1992
    ..As a functional correlate to the binding data, studies are proposed to delineate ANP effects on guanylate cyclase activity, mesangial cell sodium and calcium metabolism and intracellular PH regulation...
  49. NITRIC OXIDE & GUANYLATE CYCLASE IN LUNG CIRCULATION
    Don Nakayama; Fiscal Year: 2000
    ..The relationship between iNOS expression and cytotoxicity will be established by antisense inhibition to iNOS and GTP-CH expression. ..
  50. NO, GUANYLATE CYCLASE AND IMMUNOTHERAPY OF CANCER
    Paul Shami; Fiscal Year: 2000
    ..NO acts as a potent vasodilator by activating the soluble guanylate cyclase (sGC) and cGMP production in vascular smooth muscle cells...
  51. NO/CGMP SIGNAL TRANSDUCTION IN ACUTE PULMONARY INJURY
    KENNETH BLOCH; Fiscal Year: 1999
    ..NO acts, at least in part, by stimulating soluble guanylate cyclase (sGC), a heterodimer, to produce the intracellular second messenger cGMP...
  52. REGULATION OF CYCLIC NUCLEOTIDE FORMATION AND ACTION
    Ferid Murad; Fiscal Year: 1991
    ..proposal are to determine the mechanisms of hormone, autocoid and drug regulation of the isoenzyme forms of guanylate cyclase and cyclic GMP synthesis...
  53. TRANSDUCTION IN VERTEBRATE PHOTORECEPTORS
    Shaul Hestrin; Fiscal Year: 1991
    ..3. Determination of the specific effects of cytoplasmic calcium on guanylate cyclase in detached rod outer segments...
  54. VISUAL TRANSDUCTION IN RETINAL PHOTORECEPTORS
    King Wai Yau; Fiscal Year: 2002
    ..a) any change in the cGMP-gated channel's selectivity for Ca++ in background light, b) the relation between guanylate cyclase (the cGMP-synthesizing enzyme) and Ca++ under near-physiological conditions, c) any residual background ..
  55. GUANYLATE CYCLASE TRANSDUCTION SYSTEMS IN RETINA
    Rameshwar Sharma; Fiscal Year: 2002
    ..The foundation of the project is the cloning the native rod outer segment membrane guanylate cyclase (ROS-GC), the enzyme pivotal to both the transduction processes of vision and also to the retinal neuronal ..
  56. Specificity and Control of Signaling by S-Nitrosation
    Michael A Marletta; Fiscal Year: 2010
    ..The best studied pathway is through binding to the enzyme, soluble guanylate cyclase (sGC)...
  57. NITRIC OXIDE AND HEPATIC FUNCTION IN SEPSIS AND TRAUMA
    Timothy Billiar; Fiscal Year: 2002
    ..By activating soluble guanylate cyclase, NO inhibits the activation of the caspase cascade by TNFalpha, and via S-nitrosylation NO directly inhibits ..
  58. TOXICOLOGY OF VASCULAR NITRIC OXIDE SYNTHASES
    JOHN CATRAVAS; Fiscal Year: 1999
    ..process of iNOS (microtubules, PTK, PKC, NF-kappaB), as well as mechanisms of NO-mediated control of soluble guanylate cyclase, the enzyme responsible for mediating most of the actions of NO. Recently, we also cloned 5...
  59. CYCLIC GMP-REGULATED ION CHANNELS IN VASCULAR CELLS
    Yan Zhu; Fiscal Year: 2000
    ..Nitric oxide and related nitrovasodilators act by stimulating guanylate cyclase and elevating cyclic GMP (cGMP), but the mechanism by which increased cGMP leads to vasodilation is not ..
  60. ATP Regulation of Membrane Guanylate Cyclase
    Teresa Duda; Fiscal Year: 2003
    ..Therefore, understanding the basic steps of the molecular machinery of ANF-RGC will contribute in developing therapy for hypertension and other heart-related diseases. ..
  61. MOLECULAR MECHANISMS OF GUANYLATE CYCLASE ACTIVATION
    Chung Ho Chang; Fiscal Year: 2001
    ..the Applicant's Abstract) This is a revised proposal to investigate the involvement of a protein called the guanylate cyclase regulatory protein (GCRP) in the regulation of ANF-stimulated guanylate cyclase activity...
  62. NO/CGMP SIGNAL TRANSDUCTION SYSTEM IN VASCULAR INJURY
    KENNETH BLOCH; Fiscal Year: 2002
    ..NO acts, in part, by stimulating soluble guanylate cyclase (sGC), a heterodimer composed of alpha and beta subunits, to produce cGMP leading to activation of cGMP-..