protamine kinase

Summary

Summary: An aspect of protein kinase (EC 2.7.1.37) in which serine residues in protamines and histones are phosphorylated in the presence of ATP. EC 2.7.1.70.

Top Publications

  1. ncbi Mutagenic response of 2.45 GHz radiation exposure on rat brain
    Kavindra Kumar Kesari
    Bioelectromagnetic Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India
    Int J Radiat Biol 86:334-43. 2010
  2. pmc NHK-1 phosphorylates BAF to allow karyosome formation in the Drosophila oocyte nucleus
    Oscar M Lancaster
    The Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 179:817-24. 2007
  3. ncbi H3 phosphorylation: dual role in mitosis and interphase
    Beatriz Pérez-Cadahía
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, MB R3E0V9, Canada
    Biochem Cell Biol 87:695-709. 2009
  4. ncbi Phosphorylation of eukaryotic protein synthesis initiation factor 4E by insulin-stimulated protamine kinase
    A Makkinje
    Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Milton S Hershey Medical Center, Hershey 17033, USA
    J Biol Chem 270:14824-8. 1995
  5. pmc Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo
    Hitoshi Aihara
    Department of Biochemistry, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Genes Dev 18:877-88. 2004
  6. ncbi Histones and histone modifications
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 14:R546-51. 2004
  7. ncbi Proper chromatin condensation and maintenance of histone H3 phosphorylation during mouse oocyte meiosis requires protein phosphatase activity
    Jason E Swain
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 0617, USA
    Biol Reprod 76:628-38. 2007
  8. pmc The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster
    C Fiona Cullen
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 171:593-602. 2005
  9. pmc A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes
    Irena Ivanovska
    Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 19:2571-82. 2005
  10. ncbi Histone modifications and the chromatin scaffold for meiotic chromosome architecture
    Irena Ivanovska
    Whitehead Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Cell Cycle 5:2064-71. 2006

Scientific Experts

  • Paul J Converse
  • Kavindra K Kesari
  • Marten H Vos
  • Ann M Bode
  • Dorota Rybaczek
  • Christian Bronner
  • Lee H Wong
  • Hirofumi Yamauchi
  • A F Monroy
  • S Planchais
  • M Wilding
  • S Baatout
  • J Motlik
  • T Ohta
  • Craig Peterson
  • Takashi Ito
  • WILLIAM L KRAUS
  • Q M Chen
  • Michael B Reed
  • P Lefebvre
  • Erik T Yukl
  • Jeong Il Oh
  • Alexandra Ioanoviciu
  • Ha Yeon Cho
  • Beom Sik Kang
  • Ryan W Honaker
  • Young Min Kim
  • Paul R Ortiz de Montellano
  • Oscar M Lancaster
  • Jason E Swain
  • Ashwani Kumar
  • Hiroyuki Ohkura
  • C Fiona Cullen
  • Romain Loury
  • Irena Ivanovska
  • In Jeong Ko
  • Pierre Moenne-Loccoz
  • Hyo Je Cho
  • Amy L Brittle
  • Ha Na Lee
  • Hitoshi Aihara
  • PeiFu Zhou
  • Hongjun He
  • Chien Chih Lee
  • Hye Jin Song
  • Ashley Fallow
  • Min Ju Kim
  • Martin I Voskuil
  • Michiko M Nakano
  • Paolo Sassone-Corsi
  • B B Mull
  • D M Price
  • Matthew T Knuesel
  • Beatriz Pérez-Cadahía
  • Keiko Kawauchi
  • Jin Mok Lee
  • Juan Germán Rodriguez
  • Gary D Smith
  • Adrie J C Steyn
  • Jun Ding
  • V Swaminathan
  • Masaya Oki
  • Eduardo Henrique Silva Sousa
  • Kartik Viswanathan
  • Hao Li
  • Yukako Oda
  • Terry L Orr-Weaver
  • Fabian Oceguera-Yanez
  • Jun Dai
  • Sunita Sardiwal
  • Gargi Bagchi
  • Wan Sheng Lo
  • Angela Stephenson
  • Rebecca Kristeleit
  • Stephen S Lin
  • J G Yoo
  • Simona Saccani
  • David W McLay
  • Claudia Crosio
  • Kathrin Muegge
  • Bruno Lefebvre
  • Na On Lee
  • Si Wouk Kim
  • Yexin Zhou
  • Quanxin Long
  • Honghai Wang
  • Jianping Xie
  • Thomas C Zahrt
  • Yi Hsiung Lin
  • Renee M Penoske

Detail Information

Publications127 found, 100 shown here

  1. ncbi Mutagenic response of 2.45 GHz radiation exposure on rat brain
    Kavindra Kumar Kesari
    Bioelectromagnetic Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India
    Int J Radiat Biol 86:334-43. 2010
    ..To investigate the effect of 2.45 GHz microwave radiation on rat brain of male wistar strain...
  2. pmc NHK-1 phosphorylates BAF to allow karyosome formation in the Drosophila oocyte nucleus
    Oscar M Lancaster
    The Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 179:817-24. 2007
    ..We propose that BAF phosphorylation by NHK-1 disrupts anchorage of chromosomes to the nuclear envelope, allowing karyosome formation in oocytes. These data provide the first mechanistic insight into how the karyosome forms...
  3. ncbi H3 phosphorylation: dual role in mitosis and interphase
    Beatriz Pérez-Cadahía
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, MB R3E0V9, Canada
    Biochem Cell Biol 87:695-709. 2009
    ..The cellular contexts under which specific residues on H3 are phosphorylated in mitosis and interphase are known to some extent. However, the functional consequences of H3 phosphorylation are still unclear...
  4. ncbi Phosphorylation of eukaryotic protein synthesis initiation factor 4E by insulin-stimulated protamine kinase
    A Makkinje
    Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Milton S Hershey Medical Center, Hershey 17033, USA
    J Biol Chem 270:14824-8. 1995
    Insulin-stimulated protamine kinase (cPK) and protein kinase C (PKC) phosphorylated eukaryotic protein synthesis initiation factor 4E (eIF-4E) on serine and threonine residues located on an identical tryptic fragment as judged by two-..
  5. pmc Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo
    Hitoshi Aihara
    Department of Biochemistry, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Genes Dev 18:877-88. 2004
    ..These studies reveal that NHK-1-catalyzed phosphorylation of a conserved serine/threonine residue in H2A is a new component of the histone code that might be related to cell cycle progression...
  6. ncbi Histones and histone modifications
    Craig L Peterson
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 14:R546-51. 2004
  7. ncbi Proper chromatin condensation and maintenance of histone H3 phosphorylation during mouse oocyte meiosis requires protein phosphatase activity
    Jason E Swain
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 0617, USA
    Biol Reprod 76:628-38. 2007
    ..Furthermore, GSK3 inhibition results in aberrant chromatin condensation and appears to regulate phosphorylation of PPP1R2...
  8. pmc The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster
    C Fiona Cullen
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 171:593-602. 2005
    ..NHK-1 itself is phosphorylated in mitosis and female meiosis, suggesting that this kinase is part of the regulatory system coordinating progression of mitosis and meiosis...
  9. pmc A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes
    Irena Ivanovska
    Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 19:2571-82. 2005
    ..These studies reveal a critical role for histone modifications in chromosome dynamics in meiosis and mitosis...
  10. ncbi Histone modifications and the chromatin scaffold for meiotic chromosome architecture
    Irena Ivanovska
    Whitehead Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Cell Cycle 5:2064-71. 2006
    ..A meiotic mutation in the Drosophila histone kinase, NHK-1, uncovered a critical requirement for histone modifications in chromosome architecture, underscoring the power of this approach...
  11. ncbi Role of histone phosphorylation in chromatin dynamics and its implications in diseases
    Masaya Oki
    Department of Biochemistry, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki, Nagasaki 852 8523, Japan
    Subcell Biochem 41:319-36. 2007
    ..However, definitive roles for this modification in these processes have not yet been elucidated. In this review, we discuss recent progress in studies of histone phosphorylation...
  12. ncbi Small molecule modulators in epigenetics: implications in gene expression and therapeutics
    V Swaminathan
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, P O, Bangalore 560064, India
    Subcell Biochem 41:397-428. 2007
    ..modifying enzymes involved in gene regulation, their connection to disease manifestation and focuses on the role of small molecule modulators in understanding enzyme function and also the design and the evolution of chromatin therapeutics..
  13. ncbi Histone phosphorylation: how to proceed
    Romain Loury
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, B P 10142, Illkirch, Strasbourg 67404, France
    Methods 31:40-8. 2003
    ..These powerful approaches are important as identification of the signaling transduction routes leading to chromatin remodeling is critical to an understanding of all cellular processes...
  14. ncbi cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF
    D Arion
    CNRS, Roscoff, France
    Cell 55:371-8. 1988
    ..Since this protein is also a subunit of the M-phase promoting factor (MPF) of Xenopus oocytes, we suggest that H1K and MPF are the same entity, and that histone H1 is likely to be one substrate of the pleiotropic MPF...
  15. ncbi Nuclear receptor-dependent transcription with chromatin. Is it all about enzymes?
    W Lee Kraus
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Eur J Biochem 269:2275-83. 2002
    ..In this paper, we will present a brief overview of these enzymes, their activities, and how they assist NRs in the repression or activation of transcription in the context of chromatin...
  16. pmc O2- and NO-sensing mechanism through the DevSR two-component system in Mycobacterium smegmatis
    Jin Mok Lee
    Department of Microbiology, Pusan National University, 609 735 Busan, South Korea
    J Bacteriol 190:6795-804. 2008
    ..The three-dimensional structure of the putative GAF-B domain revealed that it has a GAF folding structure without cyclic nucleotide binding capacity...
  17. pmc Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases
    Claudia Crosio
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch Strasbourg, France
    Mol Cell Biol 22:874-85. 2002
    ..Since Aurora-A and Aurora-B are known to be overexpressed in a variety of human cancers, our findings provide an attractive link between cell transformation, chromatin modifications and a specific kinase system...
  18. ncbi The ability to develop an activity that transfers histones onto sperm chromatin is acquired with meiotic competence during oocyte growth
    David W McLay
    Department of Biology, McGill University, Montreal, Canada
    Dev Biol 241:195-206. 2002
    ....
  19. ncbi Direct interaction of p21 with p50, the small subunit of human DNA polymerase delta
    Hao Li
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 5:428-36. 2006
    ..Our results suggested that p50 might target or anchor p21 to pol delta complex upon certain DNA damage such as adriamycin treatment...
  20. ncbi Differential regulation of p34cdc2 and p33cdk2 by transforming growth factor-beta 1 in murine mammary epithelial cells
    M P Fautsch
    Thoracic Diseases Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Cell Biochem 58:517-26. 1995
    ..Thus, it appears that TGF-beta decreases the kinase activity of both cdc2 and cdk2 by distinct mechanisms...
  21. ncbi Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2
    J Pines
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, San Diego, California 92138
    Cell 58:833-46. 1989
    ..In G2/M phase, cyclin is associated with p34cdc2, the human homolog of the fission yeast gene cdc2+, and this complex has histone H1 kinase activity...
  22. pmc Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae
    S I Reed
    Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 87:5697-701. 1990
    ..The dual role of the Cdc28 protein kinase in the S. cerevisiae cell cycle thus parallels that demonstrated for the cdc2 protein kinase of the fission yeast Schizosaccharomyces pombe...
  23. ncbi A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem
    Sunita Sardiwal
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Mol Biol 353:929-36. 2005
    ..We propose that the activation of the DosS sensor is controlled through the haem binding of molecular oxygen or nitric oxide...
  24. ncbi snf1lk encodes a protein kinase that may function in cell cycle regulation
    Angela Stephenson
    Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, Room 370, Indianapolis, IN 46202, USA
    Genomics 83:1105-15. 2004
    ..We show data that indicate that SNF1LK does not share functional homology with other SNF1-related kinases, but represents a new subclass with novel molecular activities...
  25. ncbi Low temperature perception in plants: effects of cold on protein phosphorylation in cell-free extracts
    A F Monroy
    Department of Biology, McGill University, Montreal, Quebec, Canada
    FEBS Lett 410:206-9. 1997
    ....
  26. ncbi Nicotinamide alters the calcium release pattern and the degradation of MPF activity after fertilisation in ascidian oocytes
    M Wilding
    Stazione Zoologica Anton Dohrn, Naples, Italy
    Zygote 7:255-60. 1999
    ..The data demonstrate that NN metabolism is involved in calcium signalling through CICR and further suggest that a NN metabolite acts as a messenger connecting MPF activity to the formation of the meiotic apparatus...
  27. ncbi Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc
    H Karsunky
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Virchowstrasse 173, D 45122 Essen, Germany
    Oncogene 18:7816-24. 1999
    ..This would be consistent with our previous finding that cyclin E and Ha-Ras cooperate in focus formation assays in rat embryo fibroblasts...
  28. ncbi Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
    R H Chen
    Department of Physiology, University of California, San Francisco, 94143, USA Chapel Hill, NC 27599, USA
    Science 274:242-6. 1996
    ..This study furthers understanding of the mechanism of cell cycle checkpoints in metazoa and provides a marker for studying the role of the spindle assembly checkpoint in the genetic instability of tumors...
  29. ncbi Purification and characterization of a novel protamine kinase in HL60 cells
    Y Soh
    Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA
    J Biochem 127:95-103. 2000
    A protamine kinase from HL60 cells was purified to near homogeneity by DEAE-Sephacel, protamine-agarose, Hydroxylapatite, and S-200 chromatography. It was purified by 75.8-fold through four chromatographic steps, and 0...
  30. ncbi Reconstitution of cyclin-dependent cdc2 and cdk2 kinase activities in vitro
    Z Q Pan
    Graduate Program in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 268:20433-42. 1993
    ..Thus, cdk2 and cyclin A proteins are components that assemble to yield a kinase complex that catalyzes the phosphorylation of histone H1...
  31. pmc Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae
    C S Stueland
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037
    Mol Cell Biol 13:3744-55. 1993
    ..However, the active complexes in checkpoint-arrested cells are smaller than those in cycling cells, suggesting that assembly of mitosis-inducing complexes requires additional steps following histone H1 kinase activation...
  32. pmc The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2
    B Faha
    Massachusetts General Hospital Cancer Center, Charlestown 02129
    J Virol 67:2456-65. 1993
    ..Although the architecture of such interactions remains unclear, it is likely that by targeting such complexes, adenovirus is affecting some aspect of cell cycle control...
  33. ncbi Association of proliferating cell nuclear antigen with cyclin-dependent kinases and cyclins in normal and transformed human T lymphocytes
    A Szepesi
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Blood 84:3413-21. 1994
    ....
  34. pmc The meiotic recombination checkpoint suppresses NHK-1 kinase to prevent reorganisation of the oocyte nucleus in Drosophila
    Oscar M Lancaster
    The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 6:e1001179. 2010
    ..Therefore we propose that NHK-1 is a crucial regulator of meiosis and that the meiotic checkpoint suppresses NHK-1 activity to prevent oocyte nuclear reorganisation until DNA breaks are repaired...
  35. pmc Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C
    I Dominguez
    Medicina y Cirugia Experimental, Hospital General Gregorio Maranon, Madrid, Spain
    EMBO J 10:3215-20. 1991
    ..Therefore, we identify GAP as a further step required for signalling through PC-PLC, and necessary for the control of oocyte maturation in response to ras p21/insulin but not to progesterone...
  36. ncbi Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase
    B Baratte
    CNRS, Station Biologique, Roscoff, France
    Anticancer Res 12:873-80. 1992
    ..The simplicity, speed and possible extensive automation of this assay using an essential cell cycle-regulating component provide a highly specific mechanism-based screen for antimitotic drugs discovery...
  37. ncbi Involvement of the catalytically important Asp54 residue of Mycobacterium smegmatis DevR in protein-protein interactions between DevR and DevS
    Ha Na Lee
    Department of Microbiology, Pusan National University, Busan, Korea
    FEMS Microbiol Lett 343:26-33. 2013
    ..However, the K104A mutation in DevR only slightly affected protein-protein interactions between DevR and DevS...
  38. ncbi Protein kinase in cultured plant cells
    N Nakaya
    Biochim Biophys Acta 410:273-8. 1975
    ..It was thermolabile and completely dependent on the presence of Mg2+ or Mn2+ for activity. p-Chloromercuribenzoate inactivated this enzyme and this inactivation was overcome by mercaptoethanol...
  39. ncbi The "Epigenetic Code Replication Machinery", ECREM: a promising drugable target of the epigenetic cell memory
    Christian Bronner
    CNRS UMR 7175, Département de Pharmacologie et Pharmacochimie des Interactions cellulaires et moléculaires, Faculte de Pharmacie, 74 route du Rhin, B P 60024, 67401 Illkirch, France
    Curr Med Chem 14:2629-41. 2007
    ..ECREM, thus, appears to be an interesting complex to be investigated in order to find new drugs for cancer, metabolic, neuro-degenerative and inflammatory diseases therapy...
  40. ncbi Mycobacterium tuberculosis two-component systems and implications in novel vaccines and drugs
    PeiFu Zhou
    Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco Enviroment and Bio Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, China
    Crit Rev Eukaryot Gene Expr 22:37-52. 2012
    ..This review focuses on the physiological roles of TCSs and the network of M.tb TCSs from a systems biology perspective. The implications of TCSs for better vaccine and new drug targets against tuberculosis are also examined...
  41. ncbi Association of G1/S-phase and late S-phase checkpoints with regulation of cyclin-dependent kinases in Chinese hamster ovary cells
    J A D'Anna
    Life Sciences Division, Los Alamos National Laboratory, New Mexico 87545, USA
    Radiat Res 148:260-71. 1997
    ....
  42. pmc Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis
    Marten H Vos
    Laboratory for Optics and Biosciences, CNRS Ecole Polytechnique, 91128 Palaiseau, France
    Biochemistry 51:159-66. 2012
    ..The distal tyrosine, present in both proteins, plays an important role in these processes...
  43. pmc Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells
    Chien Chih Lee
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    BMC Cancer 11:58. 2011
    ..We selected aurora B and MSK1 as representatives for testing various compounds and drugs, and found that squamocin, a bis-tetrahydrofuran annonaceous acetogenin, exerted a potent effect on histone H3 phosphorylation...
  44. pmc Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants
    Ashley Fallow
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    J Bacteriol 192:2228-38. 2010
    ..Our data serve to highlight the evolutionary pressure that exists among distinct M. tuberculosis lineages to maintain tight control over DosR regulon expression...
  45. pmc A nonproteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M phase
    A Nishiyama
    Laboratory of Cell and Developmental Biology, Graduate School of Biosciences, Tokyo Institute of Technology, Midori ku, Yokohama 226 8501, Japan
    Genes Dev 14:2344-57. 2000
    ..As a result, cyclin B levels decrease on exit from M phase but Cdc2 levels remain constant...
  46. ncbi Rv3134c/devR/devS operon of Mycobacterium bovis BCG is differentially transcribed under "in vitro" stress conditions
    Juan Germán Rodriguez
    Corporación Corpogen, Carrera 5 No 66A 34, Bogota, Colombia
    Tuberculosis (Edinb) 88:273-82. 2008
    ..Our results indicate that Rv3134c/devR/devS of M. bovis BCG constitutes an operon with complex regulation that participates in bacterial response against a wide range of stresses...
  47. pmc Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models
    Paul J Converse
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Infect Immun 77:1230-7. 2009
    ..Our analyses reveal that the dosR and dosS genes are required for full virulence and that there may be differences in the patterns of attenuation of this mutant between the animal models studied...
  48. ncbi Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation
    Keiko Kawauchi
    Department of Molecular Oncology, Institute of Gerontology, Nippon Medical School, Kosugi cho 1 396, Nakahara ku, Kawasaki shi, Kanagawa 211 8533, Japan
    Biochem Biophys Res Commun 372:137-41. 2008
    ..Thus, activated p53 may suppress transcriptional activity of NF-kappaB through inhibition of IKK and histone H3 kinase on DNA, suggesting a novel p53-mediated suppression system for tumorigenesis...
  49. ncbi Down regulation of p53 with HPV E6 delays and modifies cell death in oxidant response of human diploid fibroblasts: an apoptosis-like cell death associated with mitosis
    Qin M Chen
    Department of Pharmacology, University of Arizona, College of Medicine, 1501 N Campbell Avenue, Tucson, Arizona, AZ 85724, USA
    Oncogene 21:5313-24. 2002
    ..Our data indicate that expression of HPV E6 causes a delay and morphological modification of cell death induced by oxidants. E6 cells die at mitosis, which can be inhibited by bcl-2 overexpression or caspase inhibition...
  50. ncbi Efficient production of cloned bovine embryos using cdc2 kinase inhibitor
    J G Yoo
    College of Veterinary Medicine, Gyeongsang National University, Chinju, Korea
    Reprod Domest Anim 38:444-50. 2003
    ..05) than in Group 2. It can be concluded that the use of SPP with ionomycin reduces greatly the incidence of chromosomal abnormalities, and may be applicable for the activation of nuclear transplant bovine embryos...
  51. ncbi Insulin-like growth factor-I extends in vitro replicative life span of skeletal muscle satellite cells by enhancing G1/S cell cycle progression via the activation of phosphatidylinositol 3'-kinase/Akt signaling pathway
    M V Chakravarthy
    Department of Integrative Biology, University of Texas Medical School, Houston, Texas 77030, USA
    J Biol Chem 275:35942-52. 2000
    ..These observations provide a more complete dissection of molecular events by which increased local expression of a growth factor in mature skeletal muscle fibers extends replicative life span of primary stem cells than previously known...
  52. ncbi Interaction between the cell-cycle-control proteins p34cdc2 and p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2
    L Azzi
    CNRS, Station Biologique, Roscoff, France
    Eur J Biochem 203:353-60. 1992
    ..The implications of the existence of two cooperative p34cdc2-binding domains in p9CKShs2 on the structure of the active M-phase-specific kinase is discussed...
  53. ncbi Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities
    Z Q Pan
    Graduate Program in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 268:20443-51. 1993
    ..The cyclin-activated cdc2 family kinases may target their cellular substrates through cyclin-mediated protein-protein interactions...
  54. pmc The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2
    R Y Poon
    Imperial Cancer Research Fund, Clare Hall Laboratories, Potters Bar, Herts, UK
    EMBO J 12:3123-32. 1993
    ..We conclude that p40MO15 corresponds to CAK (cdc2/cdk2 activating kinase) and speculate that, like p33cdk2 and p34cdc2, p40MO15 requires activation by phosphorylation and association with a companion subunit...
  55. pmc Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins
    M Tyers
    Cold Spring Harbor Laboratory, NY 11724
    EMBO J 12:1955-68. 1993
    ..Given the large number of known cyclins, such cyclin cascades may be a common theme in cell cycle control...
  56. ncbi HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A
    M Tommasino
    Department of Pathology, University of Cambridge, UK
    Oncogene 8:195-202. 1993
    ..The interaction appears to be via cyclin A, since probing of similar immunoblots showed a 50 kDa band corresponding to cyclin A. The association of E7 with cyclin A appeared to be direct, not involving Rb 1 or other proteins...
  57. ncbi The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5
    T Moll
    Institute for Molecular Pathology, Vienna, Austria
    Cell 66:743-58. 1991
    ..As all three serines are phosphorylated by purified CDC28-dependent H1 kinase activity in vitro, we propose a model in which the CDC28 kinase acts directly to control nuclear entry of SWI5...
  58. ncbi Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A
    A Giordano
    Freeman Laboratory of Cancer Cell Biology, Cold Spring Harbor Laboratory, NY 11724
    Science 253:1271-5. 1991
    ..This E1A complex displayed histone H1-specific kinase activity; the kinase activity was modulated during the cell division cycle, and association of pRb with E1A apparently was not required for this activity...
  59. ncbi Cyclin is a component of maturation-promoting factor from Xenopus
    J Gautier
    Department of Pharmacology, School of Medicine, University of Colorado, Denver 80262
    Cell 60:487-94. 1990
    ..Protein kinase activity against cyclin oscillates in maturing oocytes and activated eggs with the same kinetics as p34cdc2 kinase activity. These data indicate that B-type cyclin is the other component of MPF besides p34cdc2...
  60. pmc Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins
    M R Gerber
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Proc Natl Acad Sci U S A 92:4651-5. 1995
    ..cdc37-1 mutants also exhibit a defect in the binding and activation of Cdc28 by the mitotic cyclin Clb2. Thus Cdc37 may be a regulator that is required for the association of Cdc28 with multiple cyclins...
  61. pmc Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A
    H Guo
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    Proc Natl Acad Sci U S A 90:2500-4. 1993
    ..of protein phosphatase 2A2 (PP2A2) by about 80% with the autophosphorylation-activated protein kinase, protamine kinase, and 32P-labeled myelin basic protein as substrates. Analysis of incubations performed in the presence of 0...
  62. ncbi Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes
    W G Morice
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905
    J Biol Chem 268:22737-45. 1993
    ..The inhibitory effects of RAP on the activation of cyclin E- and cyclin A-associated cyclin-dependent kinases suggest that one or both events participate in the regulation of T cell entry into S-phase...
  63. ncbi Molecular cloning and identification of two types of hamster cyclin-dependent kinases: cdk2 and cdk2L
    E Noguchi
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 197:1524-9. 1993
    ..Immunoblotting analysis suggested that these two types of cdk2 protein exist in mammalian cells. The cdk2hm has the activity of protein kinase, while the cdk2Lhm does not, however, both bind with cyclin E...
  64. ncbi Influence of parthenogenetic activation on nuclear maturation of canine oocytes
    Hye Jin Song
    Gyeongsang National University, Jinju, Republic of Korea
    J Vet Med Sci 72:887-92. 2010
    ..These results indicated that ionomycin treatment at 48 hr of in vitro maturation had a positive influence on oocyte progression to the metaphase II stage...
  65. pmc The yeast SRM1 protein and human RCC1 protein share analogous functions
    K L Clark
    Institute of Molecular Biology, University of Oregon, Eugene 97403
    Cell Regul 2:781-92. 1991
    ..Finally, like RCC1, SRM1 is a nuclear protein. Together, these data imply that SRM1 and RCC1 have a common role in their respective organisms...
  66. ncbi The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae
    U Surana
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 65:145-61. 1991
    ..Our results are consistent with CDC28 function being required in both G1 and mitosis. Its mitotic role, we believe, involves interaction with a family of at least four G2-specific cyclins...
  67. pmc Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon
    Ashwani Kumar
    Department of Microbiology, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Biol Chem 283:18032-9. 2008
    ..We conclude that CO, a previously unrecognized host factor, is a physiologically relevant Mtb signal capable of inducing the Dos regulon, which introduces a new paradigm for understanding the molecular basis of Mtb persistence...
  68. pmc Crystallization and preliminary crystallographic analysis of the second GAF domain of DevS from Mycobacterium smegmatis
    Ha Yeon Cho
    School of Life Science and Biotechnology, Kyungpook National University, Daegu 702 701, Republic of Korea
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:274-6. 2008
    ..The asymmetric unit contains one molecule, corresponding to a packing density of 2.5 A(3) Da(-1). The selenium substructure was determined by the single anomalous dispersion method and structure refinement is in progress...
  69. pmc Regulation of spindle and chromatin dynamics during early and late stages of oocyte maturation by aurora kinases
    Jason E Swain
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Hum Reprod 14:291-9. 2008
    ..These data suggest a ZM-sensitive AURK may be an oocyte histone-H3 kinase capable of regulating chromatin remodeling throughout oocyte meiosis, both pre- and post-MI...
  70. pmc Transforming growth factor beta 1 (TGF beta 1) reduces cellular levels of p34cdc2, and this effect is abrogated by adenovirus independently of the E1A-associated pRB binding activity
    S E Abraham
    Cold Spring Harbor Laboratory, New York 11724
    Mol Biol Cell 3:655-65. 1992
    ..Overall our results suggest that TGF beta 1 acts by signaling changes at the level of control of G1 gene expression, not at the level of posttranslational modification of p34cdc2 or its substrates...
  71. pmc Components of the Rv0081-Rv0088 locus, which encodes a predicted formate hydrogenlyase complex, are coregulated by Rv0081, MprA, and DosR in Mycobacterium tuberculosis
    Hongjun He
    Department of Microbiology and Molecular Genetics, Center for Infectious Disease Research, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    J Bacteriol 193:5105-18. 2011
    ..Based on this and other published information, a model is proposed detailing Rv0081-Rv0088 expression by these transcription factors within particular growth environments...
  72. ncbi Association of cdk2 kinase with the transcription factor E2F during S phase
    M Pagano
    European Molecular Biology Laboratory, Heidelberg, Germany
    Science 255:1144-7. 1992
    ..These data suggest that the interaction between cdk2 and E2F requires an active kinase that has cyclin A as a targeting component...
  73. pmc DNA metabolism gene CDC7 from yeast encodes a serine (threonine) protein kinase
    R E Hollingsworth
    Department of Biochemistry, Biophysics, and Genetics, University of Colorado Health Sciences Center, Denver 80262
    Proc Natl Acad Sci U S A 87:6272-6. 1990
    ..Because Cdc7 kinase acts downstream of Cdc28/cdc2 kinase function at "start," the transition from G1 to S phase in the cell cycle may be the result of a cascade of protein phosphorylation...
  74. pmc Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor
    Ashwani Kumar
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11568-73. 2007
    ..We conclude that Mtb has evolved finely tuned redox and hypoxia-mediated sensing strategies for detecting O2, NO, and CO. Data presented here establish a paradigm for understanding the mechanism of bacilli persistence...
  75. pmc DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis
    Eduardo Henrique Silva Sousa
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Protein Sci 16:1708-19. 2007
    ..They also explain why exposure of M. tuberculosis to NO donors under aerobic conditions can give results identical to hypoxia, i.e., NO saturates DosT, preventing O(2) binding and yielding an active kinase...
  76. pmc A distal tyrosine residue is required for ligand discrimination in DevS from Mycobacterium tuberculosis
    Erik T Yukl
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, 20000 NW Walker Road, Beaverton, Oregon 97006 8921, USA
    Biochemistry 47:12532-9. 2008
    ..This mechanistic model is consistent with Tyr171 being required for distal ligand discrimination, but nonessential for autophosphorylation activity...
  77. pmc Nitric oxide dioxygenation reaction in DevS and the initial response to nitric oxide in Mycobacterium tuberculosis
    Erik T Yukl
    Division of Environmental and Biomolecular Systems, Oregon Health and Science University, 20000 Northwest Walker Road, Beaverton, Oregon 97006 8921, United States
    Biochemistry 50:1023-8. 2011
    ....
  78. ncbi Etoposide induces TRP53-dependent apoptosis and TRP53-independent cell cycle arrest in trophoblasts of the developing mouse placenta
    Hirofumi Yamauchi
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biol Reprod 80:813-22. 2009
    ..Our study demonstrated that etoposide injection induced TRP53-dependent apoptosis and TRP53-independent cell cycle arrest in labyrinthine trophoblasts, providing insights into the molecular pathway of placental disorders...
  79. ncbi Microwave exposure affecting reproductive system in male rats
    Kavindra Kumar Kesari
    Bioelectromagnetic Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India
    Appl Biochem Biotechnol 162:416-28. 2010
    ..019). We conclude that these radiations may have a significant effect on reproductive system of male rats, which may be an indication of male infertility...
  80. ncbi Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase
    L H Tsai
    Massachusetts General Hospital Cancer Center, Charlestown 02129
    Nature 353:174-7. 1991
    ..As p33cdk2 is bound to cyclin A and is targeted by the viral E1A protein, we suggest that the p33cdk2/cyclin A complex has a unique role in cell-cycle regulation of vertebrate cells...
  81. pmc Different roles of DosS and DosT in the hypoxic adaptation of Mycobacteria
    Min Ju Kim
    Department of Microbiology, Pusan National University, Busan 609 735, Republic of Korea
    J Bacteriol 192:4868-75. 2010
    ....
  82. pmc Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
    Ryan W Honaker
    University of Colorado Denver, Department of Microbiology, Aurora, CO 80045, USA
    Infect Immun 77:3258-63. 2009
    ..Thus, M. tuberculosis has evolved a system whereby it responds to hypoxic conditions in a stepwise fashion as it enters an anaerobic state...
  83. pmc DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy
    Alexandra Ioanoviciu
    Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158 2517, USA
    Biochemistry 48:5839-48. 2009
    ..Our results indicate that DevS is a gas sensor in vivo rather than a redox sensor and that the stability of its ferrous-oxy complex is enhanced by interdomain interactions...
  84. pmc DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon
    Ryan W Honaker
    Department of Microbiology, University of Colorado Denver, School of Medicine, P18 9115, 12800 East 19th Avenue, PO Box 6511, Aurora, Colorado 80045, USA
    J Bacteriol 192:6447-55. 2010
    ..Although this report demonstrates that DosS responds to a reduced ETS, it does not rule out a role for oxygen in silencing signaling...
  85. ncbi Post-translational modification and stability of low molecular weight cyclin E
    B B Mull
    Department of Experimental Radiation Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 28:3167-76. 2009
    ..The stability of low molecular weight cyclin E may have implications for both tumorigenesis and treatment of tumors expressing them...
  86. ncbi Effects of radiofrequency electromagnetic wave exposure from cellular phones on the reproductive pattern in male Wistar rats
    Kavindra Kumar Kesari
    Bioelectromagnetic Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India
    Appl Biochem Biotechnol 164:546-59. 2011
    ..It is concluded that radiofrequency electromagnetic wave from commercially available cell phones might affect the fertilizing potential of spermatozoa...
  87. pmc Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells
    Lee H Wong
    Chromosome and Chromatin Research Laboratory, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville 3052, Victoria, Australia
    Genome Res 19:404-14. 2009
    ..The distinctive changes in H3.3 distribution suggests the existence of a unique and functionally essential telomere chromatin in ES cells that undergoes dynamic differentiation-dependent remodeling during the process of differentiation...
  88. ncbi Nocturnal activation of aurora C in rat pineal gland: its role in the norepinephrine-induced phosphorylation of histone H3 and gene expression
    D M Price
    Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Endocrinology 150:2334-41. 2009
    ..This phenomenon suggests that activation of this mitotic kinase can be induced by extracellular signals to participate in the transcriptional induction of a subset of genes in the rat pineal gland...
  89. pmc Concerted action of Aurora B, Polo and NHK-1 kinases in centromere-specific histone 2A phosphorylation
    Amy L Brittle
    The Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK
    Exp Cell Res 313:2780-5. 2007
    ..Epistasis analysis indicated that Polo functions upstream of the H2A kinase NHK-1 but parallel to Aurora B. Therefore, multiple mitotic kinases work together to specify the spatial and temporal pattern of H2A T119 phosphorylation...
  90. ncbi Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis
    A O Morla
    Department of Biology, University of California, La Jolla, San Diego 92093
    Cell 58:193-203. 1989
    ..Tyrosine dephosphorylation of cdc2 may be one of a number of obligatory steps in the mitotic activation of the kinase...
  91. ncbi Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF
    G Draetta
    Cold Spring Harbor Laboratory, New York 11724
    Cell 56:829-38. 1989
    ..We suggest that in addition to the cdc2 protein kinase, the cyclins are further components of the M phase promoting factor and that cyclin proteolysis provides the mechanism of MPF inactivation and thus exit from mitosis...
  92. ncbi Histone modification enzymes: novel targets for cancer drugs
    Rebecca Kristeleit
    Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, UK
    Expert Opin Emerg Drugs 9:135-54. 2004
    ..It is likely that many of the enzymes involved in the control of histone modification will provide therapeutic opportunities for the treatment of cancer, including histone methyltransferases and Aurora kinases...
  93. ncbi Analysis of histone phosphorylation: coupling intracellular signaling to chromatin remodeling
    Romain Loury
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 67404 Illkirch, Strasbourg, France
    Methods Enzymol 377:197-212. 2004
  94. ncbi Histone modification patterns during gene activation
    Wan Sheng Lo
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Methods Enzymol 377:130-53. 2004
  95. pmc Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle
    H J Yoon
    Braun Laboratories, California Institute of Technology, Pasadena 91125
    Mol Biol Cell 4:195-208. 1993
    ..Cdc7 protein carrying a serine to alanine change in the consensus recognition site for Cdc28 kinase shows an altered phosphopeptide map, suggesting that this site is important in determining the overall Cdc7 phosphorylation pattern...
  96. ncbi Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing
    Stephen S Lin
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:13390-7. 2003
    ....
  97. pmc Phosphorylation of histone H3 is functionally linked to retinoic acid receptor beta promoter activation
    Bruno Lefebvre
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO Rep 3:335-40. 2002
    ..Since such post-translational modifications were not observed at several other promoters, we conclude that histone H3 phosphorylation may be a molecular signature of the activated, retinoid-controlled mRARbeta2 gene promoter...
  98. pmc Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
    A Yamamoto
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    J Cell Biol 133:99-110. 1996
    ..Therefore, in the DNA-damage checkpoint, Pds1p is required for the inhibition of cytokinesis and DNA replication as well as anaphase. The role of Pds1 protein in anaphase inhibition and general cell cycle regulation is discussed...
  99. ncbi Preparing the target for the bullet
    Kathrin Muegge
    Nat Immunol 3:16-7. 2002
  100. ncbi p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment
    Simona Saccani
    Institute for Research in Biomedicine, Via Vela 6, CH 6501, Bellinzona, Switzerland
    Nat Immunol 3:69-75. 2002
    ..These results show that p38 plays an additional role in the induction of the inflammatory and immune response: the regulation of NF-kappa B recruitment to selected chromatin targets...
  101. ncbi A conditional lethal mutant in the fission yeast 26 S protease subunit mts3+ is defective in metaphase to anaphase transition
    C Gordon
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, Scotland, United Kingdom
    J Biol Chem 271:5704-11. 1996
    ..The deduced amino acid sequences of both mts3+ and NIN1 show homology to peptide sequences obtained from subunit 14 of the 26 S protease purified from bovine or human cells...

Research Grants5

  1. Translational Control of Oxidative Stress in Myocardial Infarction
    Qin M Chen; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This grant proposes to study the mechanism of Nrf2 protein translation in cardiomyocytes and in the myocardium following oxidative stress. ..
  2. MOLECULAR MECHANISMS OF OXIDANT TOXICITY
    Qin Chen; Fiscal Year: 2004
    ..We have a unique finding of premature senescence with oxidative stress and will combine in vitro and in vivo approaches to uncover the trigger of unwanted effects of aging. ..
  3. Analysis of SWI1, SWI2, amd SWI3 proteins
    Craig Peterson; Fiscal Year: 2005
    ..This aim also describes a conditional degron strategy to define the role(s) of individual SWI/SNF subunits for both in vivo and in vitro functions ..
  4. Steroid As Cytoprotectants against Oxidative Toxicity
    Qin Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. The Role of PARP-1 in Hormone-Regulated Transcription
    William Kraus; Fiscal Year: 2007
    ..Given the roles of PARP-1 and ERa in human disease, our studies could also lead to new ways to exploit these factors as therapeutic targets. ..