Genomes and Genes
Summary: A member of the caspase family that is highly specific for interleukin-1beta (INTERLEUKIN-1). It plays a role in inflammation and mammalian APOPTOSIS. Interleukin-1beta converting enzyme is frequently abbreviated ICE. EC 184.108.40.206
Publications292 found, 100 shown here
- Gout-associated uric acid crystals activate the NALP3 inflammasomeFabio Martinon
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Nature 440:237-41. 2006..These findings provide insight into the molecular processes underlying the inflammatory conditions of gout and pseudogout, and further support a pivotal role of the inflammasome in several autoinflammatory diseases...
- Immunological and inflammatory functions of the interleukin-1 familyCharles A Dinarello
Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
Annu Rev Immunol 27:519-50. 2009....
- Cryopyrin activates the inflammasome in response to toxins and ATPSanjeev Mariathasan
Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 440:228-32. 2006..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
- Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasomeKiichi Nakahira
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Immunol 12:222-30. 2011..Our study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondrial integrity...
- The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaFabio Martinon
Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Mol Cell 10:417-26. 2002..Thus, the inflammasome constitutes an important arm of the innate immunity...
- Non-canonical inflammasome activation targets caspase-11Nobuhiko Kayagaki
Department of Physiological Chemistry, Genentech Inc, South San Francisco, California 94080, USA
Nature 479:117-21. 2011..These data highlight a unique pro-inflammatory role for caspase-11 in the innate immune response to clinically significant bacterial infections...
- Inflammasomes in health and diseaseTill Strowig
Department of Immunobiology, Yale University, Connecticut 06520, USA
Nature 481:278-86. 2012..We review the functions of the different inflammasome complexes and discuss how aberrations in them are implicated in the pathogenesis of human diseases...
- Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteriaEdward A Miao
Institute for Systems Biology, Seattle, Washington, USA
Nat Immunol 11:1136-42. 2010..This demonstrates that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system...
- AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCVeit Hornung
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 458:514-8. 2009..Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1...
- The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesisLuigi Franchi
Department of Pathology, Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nat Immunol 10:241-7. 2009..Thus, understanding inflammasome pathways may provide insight into disease pathogenesis that might identify potential targets for therapeutic intervention...
- Biologic basis for interleukin-1 in diseaseC A Dinarello
Department of Medicine, Tufts University, Boston, MA USA
Blood 87:2095-147. 1996..At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease...
- The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesVijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Immunol 11:395-402. 2010..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity...
- Differential activation of the inflammasome by caspase-1 adaptors ASC and IpafSanjeev Mariathasan
Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 430:213-8. 2004..Notably, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways...
- The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatusYue Zhao
Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Nature 477:596-600. 2011....
- Type I interferon inhibits interleukin-1 production and inflammasome activationGreta Guarda
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Immunity 34:213-23. 2011..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
- Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptorPablo Pelegrin
Department of Biomedical Science, University of Sheffield, Sheffield, UK
EMBO J 25:5071-82. 2006....
- Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via IpafEdward A Miao
Institute for Systems Biology, Seattle, Washington 98103, USA
Nat Immunol 7:569-75. 2006....
- Caspase-1-induced pyroptotic cell deathEdward A Miao
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Immunol Rev 243:206-14. 2011..We further review the importance of pyroptosis in vivo as a potent mechanism to clear intracellular pathogens...
- Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificityEric M Kofoed
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Nature 477:592-5. 2011..cytosolic multiprotein complexes that initiate innate immune responses to pathogenic microbes by activating the caspase 1 protease...
- Pyroptosis: host cell death and inflammationTessa Bergsbaken
Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
Nat Rev Microbiol 7:99-109. 2009..Pyroptosis, or caspase 1-dependent cell death, is inherently inflammatory, is triggered by various pathological stimuli, such as stroke, ..
- Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisD W Nicholson
Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
Nature 376:37-43. 1995..A potent peptide aldehyde inhibitor has been developed and shown to prevent apoptotic events in vitro, suggesting that apopain/CPP32 is important for the initiation of apoptotic cell death...
- Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophagesLuigi Franchi
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nat Immunol 7:576-82. 2006..Thus, detection of flagellin through Ipaf induces caspase-1 activation independently of Toll-like receptor 5 in salmonella-infected and lipopolysaccharide-tolerized macrophages...
- P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smokeSuffwan Eltom
Respiratory Pharmacology, Airway Disease Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
PLoS ONE 6:e24097. 2011..The aim of this study was to determine whether activation of the P2X7/caspase 1 pathway has a functional role in CS-induced airway inflammation...
- Glyburide inhibits the Cryopyrin/Nalp3 inflammasomeMohamed Lamkanfi
Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
J Cell Biol 187:61-70. 2009..Therefore, glyburide is the first identified compound to prevent Cryopyrin activation and microbial ligand-, DAMP-, and crystal-induced IL-1beta secretion...
- Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunityTao Ren
Genetics Department, Harvard Medical School, Boston, Massachusetts, USA
PLoS Pathog 2:e18. 2006..It thus appears that macrophages sense cytosolic flagellin via a TLR5-independent pathway that leads to rapid caspase-1-dependent cell death and provides defense against intracellular bacterial pathogens...
- NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorderLaetitia Agostini
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Immunity 20:319-25. 2004..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders...
- The pannexin 1 channel activates the inflammasome in neurons and astrocytesWilliam R Silverman
Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
J Biol Chem 284:18143-51. 2009..Thus, in contrast to macrophages and monocytes in which low intracellular K(+) has been suggested to trigger inflammasome activation, in neural cells, high extracellular K(+) activates caspase-1 probably through pannexin 1...
- Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defenceOlaf Gross
III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
Nature 459:433-6. 2009..Thus, our results demonstrate the molecular basis for IL-1beta production after fungal infection and identify a crucial function for the Nlrp3 inflammasome in mammalian host defence in vivo...
- Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processingPetr Broz
Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
Cell Host Microbe 8:471-83. 2010..Our results suggest the formation of spatially and functionally distinct inflammasomes complexes in response to bacterial pathogens...
- Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumorsFrancois Ghiringhelli
Institut National de la Sante et de la Recherche Medicale, U805, Villejuif, France
Nat Med 15:1170-8. 2009..These results indicate that the NLRP3 inflammasome links the innate and adaptive immune responses against dying tumor cells...
- Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspasesAlexander U Lüthi
Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland
Immunity 31:84-98. 2009..Thus, caspase-mediated proteolysis acts as a switch to dampen the proinflammatory properties of IL-33...
- Molecular mechanism of NLRP3 inflammasome activationChengcheng Jin
Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, TAC S 560, New Haven, CT 06520, USA
J Clin Immunol 30:628-31. 2010..Three signaling pathways involving potassium efflux, generation of reactive oxygen species, and cathepsin B release are discussed...
- A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion systemIgor E Brodsky
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Cell Host Microbe 7:376-87. 2010..These data demonstrate that a class of bacterial proteins interferes with cellular recognition of bacterial secretion systems and contributes to bacterial survival within host tissues...
- ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophagesCristiane M Cruz
School of Natural Sciences, University of California, Merced, California 95344, USA
J Biol Chem 282:2871-9. 2007....
- Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophagesSusan L Fink
Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA
Cell Microbiol 8:1812-25. 2006..This mechanism of caspase-1-mediated cell death provides additional experimental evidence supporting pyroptosis as a novel pathway of inflammatory programmed cell death...
- NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbetaFlorian R Greten
Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
Cell 130:918-31. 2007..These results unravel an unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production and highlight potential complications of long-term IKKbeta inhibition...
- The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infectionDario S Zamboni
Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536, USA
Nat Immunol 7:318-25. 2006..These results establish Birc1e as a nucleotide-binding oligomerization-leucine-rich repeat protein involved in the detection and control of intracellular L. pneumophila...
- Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1Olaf Gross
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
Immunity 36:388-400. 2012..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders...
- Active caspase-1 is a regulator of unconventional protein secretionMartin Keller
Institute of Cell Biology, Department of Biology, ETH Zurich, CH 8093 Zurich, Switzerland
Cell 132:818-31. 2008..By this mechanism, stress-induced activation of caspase-1 directly links inflammation to cytoprotection, cell survival, and regenerative processes...
- Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survivalLaure Gurcel
Department Microbiology and Molecular Medicine, University of Geneva, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
Cell 126:1135-45. 2006....
- Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophagesMihai G Netea
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
Blood 113:2324-35. 2009..We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation...
- Regulation of Legionella phagosome maturation and infection through flagellin and host IpafAmal Amer
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 281:35217-23. 2006..These results reveal that Ipaf restricts Legionella replication through the regulation of phagosome maturation, providing a novel function for NLR proteins in host defense against an intracellular bacterium...
- The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activityLuigi Franchi
Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
Eur J Immunol 38:2085-9. 2008..These results indicate that alum induces IL-1beta via the Nlrp3 inflammasome but this activity is dispensable for alum-mediated adjuvant activity...
- Inflammasome recognition of influenza virus is essential for adaptive immune responsesTakeshi Ichinohe
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
J Exp Med 206:79-87. 2009..These results demonstrate that in addition to the TLR pathways, ASC inflammasomes play a central role in adaptive immunity to influenza virus...
- Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophagesToshihiko Suzuki
Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
PLoS Pathog 3:e111. 2007..Furthermore, the absence of Ipaf or caspase-1, but not ASC, regulates pyroptosis and the induction of autophagy in Shigella-infected macrophages, providing a novel function for NLR proteins in bacterial-host interactions...
- Phosphorylation of NLRC4 is critical for inflammasome activationYan Qu
Department of Physiological Chemistry, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 490:539-42. 2012..typhimurium infection, so phosphorylation of NLRC4 S533 probably drives conformational changes necessary for NLRC4 inflammasome activity and host innate immunity...
- AIM2 activates the inflammasome and cell death in response to cytoplasmic DNATeresa Fernandes-Alnemri
Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Nature 458:509-13. 2009..This study identifies AIM2 as an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1...
- Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasomeFayyaz S Sutterwala
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
J Exp Med 204:3235-45. 2007..This study shows a key role for IPAF and capase-1 in innate immune responses to the pathogen P. aeruginosa, and also demonstrates that virulent ExoU-expressing strains of P. aeruginosa can circumvent this innate immune response...
- Mycobacterium tuberculosis prevents inflammasome activationSharon S Master
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Cell Host Microbe 3:224-32. 2008..Thus, we uncovered a previously masked role for IL-1beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1beta activation...
- Emerging inflammasome effector mechanismsMohamed Lamkanfi
Department of Biochemistry, Ghent University, Ghent, Belgium
Nat Rev Immunol 11:213-20. 2011b>Caspase 1 activation by inflammasome complexes in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) induces the maturation and secretion of the pro-inflammatory cytokines ..
- An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicansAmy G Hise
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106, USA
Cell Host Microbe 5:487-97. 2009..Therefore, in addition to sensing bacterial and viral pathogens, the NLRP3 inflammasome senses fungal pathogens and is critical in host defense against Candida...
- The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzymeJ Yuan
Program of Neurosciences, Harvard Medical School, Boston, Massachusetts 02115
Cell 75:641-52. 1993..We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals...
- Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammationKristiina Rajamäki
Wihuri Research Institute, Helsinki, Finland
PLoS ONE 5:e11765. 2010..As cholesterol crystals are abundant in atherosclerotic lesions, and IL-1beta has been linked to atherogenesis, we explored the possibility that cholesterol crystals promote inflammation by activating the inflammasome pathway...
- Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cellsRobin R Craven
Department of Medicine Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS ONE 4:e7446. 2009..aureus virulence factor to a specific host signaling pathway. The cellular events linked to inflammasome activity have clear relevance to the disease processes associated with CA-MRSA including tissue necrosis and inflammation...
- Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infectionSarah E Warren
Department of Immunology, University of Washington, Seattle WA 98195, USA
J Immunol 180:7558-64. 2008..Cytosolic L. monocytogenes activates caspase 1, resulting in post-translational processing of the cytokines IL-1beta and IL-18 as well as caspase 1-dependent ..
- Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signalingThirumala Devi Kanneganti
Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Immunity 26:433-43. 2007..These results provide evidence for cytosolic delivery and sensing of bacterial molecules as a unifying model for caspase-1 activation and position pannexin-1 as a mechanistic link between bacterial stimuli and the cryopyrin inflammasome...
- Substrate specificities of caspase family proteasesR V Talanian
BASF Bioresearch Corp, Worcester, Massachusetts 01605, USA
J Biol Chem 272:9677-82. 1997..The results also suggest the design of optimal peptidic substrates and inhibitors...
- Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivoKatrin D Mayer-Barber
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 184:3326-30. 2010..Together our findings reveal a major role for IL-1beta in host resistance to M. tuberculosis and indicate that during this infection the cytokine can be generated by a mechanism that does not require TLR signaling or caspase-1...
- Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagyNicolas Dupont
Cellular Microbiology and Infectious Pathogeny UMR8161 CNRS, 1 rue du Prof Calmette, F 59021 Lille, France
Cell Host Microbe 6:137-49. 2009....
- NLRs at the intersection of cell death and immunityJenny P Y Ting
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
Nat Rev Immunol 8:372-9. 2008....
- Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASCStephen B Willingham
Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Cell Host Microbe 2:147-59. 2007..While similar proteins mediate pathogen-induced cell death in plants, this report identifies cryopyrin as an important host regulator of programmed pathogen-induced necrosis in animals, a process we term pyronecrosis...
- NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defenseLuigi Franchi
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
Nat Immunol 13:449-56. 2012..Thus, NLRC4-dependent production of IL-1β by intestinal phagocytes represents a specific response that discriminates pathogenic bacteria from commensal bacteria and contributes to host defense in the intestine...
- Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infectionChang Chieh Chen
Green Energy and Environment Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu, Taiwan, Republic of China
PLoS ONE 7:e36292. 2012..Finally, the secreted IL-1β derived from caspase-1 activation was shown to restrict intracellular M. kansasii. These findings demonstrate a biological role for the NLRP3 inflammasome in host defense against M. kansasii...
- Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4Bo Hu
Department of Immunobiology, Section of Comparative Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 107:21635-40. 2010..We suggest a model in which the NLRC4 inflammasome is central to colonic inflammation-induced tumor formation through regulation of epithelial cell response to injury...
- Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICES Wang
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 92:501-9. 1998..Our data suggest that caspase-11 is a component of ICE complex and is required for the activation of ICE...
- Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymeraseM Tewari
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
Cell 81:801-9. 1995..Furthermore, CrmA blocked cleavage of PARP in cells undergoing apoptosis. We propose that Yama may represent an effector component of the mammalian cell death pathway and suggest that CrmA blocks apoptosis by inhibiting Yama...
- Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasomeChristine Juliana
Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 285:9792-802. 2010..Our results thus elucidate the molecular mechanism for the therapeutic anti-inflammatory activity of parthenolide and identify vinyl sulfones as a new class of potential therapeutics that target the NLRP3 inflammasome...
- Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophilaChristopher L Case
Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
Infect Immun 77:1981-91. 2009..pneumophila replication in mice. Thus, L. pneumophila-mediated caspase-1 activation involves the coordinate activities of inflammasomes differentially regulated by Ipaf and Asc...
- The role of potassium in inflammasome activation by bacteriaCecilia S Lindestam Arlehamn
Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow G12 8TA, Scotland, United Kingdom
J Biol Chem 285:10508-18. 2010..The inhibitory effect of raised extracellular K(+) on NLRC4 activation thus reflects a requirement for a decrease in intracellular K(+) for this inflammasome component as well as that described for NLRP3...
- A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytesN A Thornberry
Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
Nature 356:768-74. 1992..Selective inhibition of the enzyme in human blood monocytes blocks production of mature IL-1 beta, indicating that it is a potential therapeutic target...
- Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanismsSusan L Fink
Molecular and Cellular Biology Program, Departments of Microbiology and Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 105:4312-7. 2008....
- The inflammasomes: mechanisms of activation and functionEicke Latz
University of Massachusetts Medical School, Department of Infectious Diseases and Immunology, 364 Plantation St, Worcester, MA 01605, USA
Curr Opin Immunol 22:28-33. 2010..Recent work proposes that NLRP3 is activated indirectly by host factors that are generated in response to NLRP3 triggers...
- Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvantsStephanie C Eisenbarth
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 453:1122-6. 2008..This is likely to affect how we design effective, but safe, adjuvants in the future...
- Cell death in the host response to infectionK Labbe
Department of Microbiology and Immunology, McGill University, Montreal, Canada H3A 2B4
Cell Death Differ 15:1339-49. 2008..The pathways leading to cell death by infection are discussed with a focus on the role of pattern recognition receptors in the activation of survival and death effectors...
- Human ICE/CED-3 protease nomenclatureE S Alnemri
Cell 87:171. 1996
- Inflammasomes: too big to missAndrea Stutz
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Clin Invest 119:3502-11. 2009..We discuss the current knowledge of the mechanisms leading to the activation of cytoplasmic, multimolecular protein complexes, termed "inflammasomes," which regulate the activity of caspase-1 and the maturation and release of IL-1beta...
- Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous diseaseFrank L van de Veerdonk
Department of Medicine, Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation, and Immunity N4i, 6500 HB Nijmegen, The Netherlands
Proc Natl Acad Sci U S A 107:3030-3. 2010..The absence of ROS in CGD monocytes may explain the presence of an inflammatory phenotype characterized by granulomas and inflammatory bowel disease occurring in CGD patients...
- Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxinEric D Boyden
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 38:240-4. 2006....
- Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitmentMahtab Moayeri
Laboratory of Bacterial Diseases, Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Pathog 6:e1001222. 2010..These data confirm an inverse relationship between murine macrophage sensitivity to lethal toxin and mouse susceptibility to spore infection, and establish roles for Nlrp1b(S), caspase-1, and IL-1β in countering anthrax infection...
- Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptorJurgen Harder
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 183:5823-9. 2009..pyogenes peritoneal infection. These results indicate that caspase-1 activation in response to S. pyogenes infection requires NF-kappaB and the virulence factor streptolysin O, but proceeds independently of P2X7R and TLR signaling...
- Pseudomonas aeruginosa activates caspase 1 through IpafEdward A Miao
Institute for Systems Biology, Seattle, WA 98103, USA
Proc Natl Acad Sci U S A 105:2562-7. 2008The innate immune system encodes cytosolic Nod-like receptors (NLRs), several of which activate caspase 1 processing and IL-1beta and IL-18 secretion...
- Superoxide dismutase 1 regulates caspase-1 and endotoxic shockFelix Meissner
Department of Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
Nat Immunol 9:866-72. 2008..Our findings identify a physiological post-translational mechanism in the control of caspase-1-mediated inflammatory processes...
- An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophagesSonal Khare
Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Immunity 36:464-76. 2012..Our study therefore increases our currently limited understanding of NLR activation, inflammasome assembly, and maturation of IL-1β and IL-18 in human macrophages...
- Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane traffickingJianning Ge
National Institute of Biological Sciences, Beijing 102206, China
Proc Natl Acad Sci U S A 109:6193-8. 2012..Our data together suggest a possible link, mediated by the function of SdhA, between LCV trafficking/maturation and suppression of host innate immune detection...
- Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasomeKatherine Labbe
Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3G 0B1, Canada
Immunity 35:897-907. 2011..Our results describe a role for the cIAPs in innate immunity and further demonstrate the evolutionary conservation between cell death and inflammation mechanisms...
- Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1Jean Marie Bruey
Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Cell 129:45-56. 2007..The findings reveal an interaction of host defense and apoptosis machinery...
- Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinaseNajwane Saïd-Sadier
Health Sciences Research Institute and School of Natural Sciences, University of California Merced, Merced, California, USA
PLoS ONE 5:e10008. 2010....
- Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatisAli A Abdul-Sater
Health Sciences Research Institute and School of Natural Sciences, University of California, Merced, California 95343, USA
J Biol Chem 284:26789-96. 2009..Here we show that, in cervical epithelial cells, caspase-1 activation is required for optimal growth of the intracellular chlamydiae...
- NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responsesDenis Gris
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
J Immunol 185:974-81. 2010..Thus, NLRP3 plays a critical role in the induction of the EAE, likely through effects on capase-1-dependent cytokines which then influence Th1 and Th17...
- A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptideLi Chung Hsu
Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 105:7803-8. 2008..Thus, NOD2 plays a key role in the B. anthracis-induced inflammatory response by being a critical mediator of IL-1beta secretion...
- Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infectionBarbel Raupach
Department of Cellular Microbiology, Max Planck Institut für Infektionsbiologie, Schumannstrasse 21 22, 10117 Berlin, Germany
Infect Immun 74:4922-6. 2006..Thus, we show that Casp-1 is essential for host innate immune defense against S. enterica serovar Typhimurium and that Casp-1 substrates are required at distinct times and anatomical sites...
- Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shockP Li
BASF Bioresearch Corporation, Worcester, Massachusetts 01605 4314
Cell 80:401-11. 1995..ICE therefore plays a dominant role in the generation of mature IL-1 beta, a previously unsuspected role in production of IL-1 alpha, but has no autonomous function in apoptosis...
- Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous diseaseFelix Meissner
Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany
Blood 116:1570-3. 2010..Our results identify phagocyte oxidase defective monocytes as a source of elevated IL-1 and provide a potential therapeutic option to ameliorate inflammatory conditions associated with CGD...
- The AIM2 inflammasome is critical for innate immunity to Francisella tularensisTeresa Fernandes-Alnemri
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Nat Immunol 11:385-93. 2010..tularensis infection or the presence of cytoplasmic DNA. Our study identifies AIM2 as a crucial sensor of F. tularensis infection and provides genetic proof of its critical role in host innate immunity to intracellular pathogens...
- Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against SalmonellaPetr Broz
Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA, USA
J Exp Med 207:1745-55. 2010..typhimurium, mice lacking both NLRs were markedly more susceptible to infection. These results reveal unexpected redundancy among NLRs in host defense against intracellular pathogens in vivo...
- Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1Erin McElvania TeKippe
Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS ONE 5:e12320. 2010..These data demonstrate that PYCARD exerts a novel inflammasome-independent role during chronic Mtb infection by containing the bacteria in granulomas...
- An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasomeTilmann Burckstummer
Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Nat Immunol 10:266-72. 2009..Reconstitution of unresponsive HEK293 cells with AIM2, ASC, caspase-1 and interleukin 1beta showed that AIM2 was sufficient for inflammasome activation. Our data suggest that AIM2 is a cytoplasmic DNA sensor for the inflammasome...
- Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulationLuigi Franchi
University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
J Immunol 183:792-6. 2009..These results provide a mechanism by which danger signals and particulate matter mediate inflammation via the Nlrp3 inflammasome in the absence of microbial infection...
- The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytesLaurence Feldmeyer
Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
Curr Biol 17:1140-5. 2007..This supports the concept that keratinocytes are important immuno-competent cells under physiological and pathological conditions ...
- Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinasesMarina Tiemi Shio
Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
PLoS Pathog 5:e1000559. 2009..These findings not only identify one way by which the immune system is alerted to malarial infection but also are one of the first to suggest a role for tyrosine kinase signaling pathways in regulation of the NLRP3 inflammasome...
- Molecular cloning of the interleukin-1 beta converting enzymeD P Cerretti
Immunex Corporation, Seattle, WA 98101
Science 256:97-100. 1992..Sequence analysis indicated that the enzyme itself may undergo proteolytic processing. The gene encoding the protease was mapped to chromosomal band 11q23, a site frequently involved in rearrangement in human cancers...
- NIH Director's Pioneer AwardJunying Yuan; Fiscal Year: 2009..No Abstract provided ..
- Pulmonary Defenses Against Intracellular InfectionShawn J Skerrett; Fiscal Year: 2013....
- Sterile Hepatic InflammationWajahat Zafar Mehal; Fiscal Year: 2012..The knowledge gained from this project will therefore directly result in designing rational therapies for these conditions. ..
- Immunobiology of Acute Environmental AsthmaDavid B Peden; Fiscal Year: 2013..The inflammasome complex is required for procaspase 1 processing to mature caspase 1. In turn, caspase-1 is required for the processing of pro-IL-1 and pro-IL-18 to their mature forms...
- TARGETING FLIP FOR PROSTATE CANCER PREVENTIONAddanki P Kumar; Fiscal Year: 2012....
- Mechanistic study of the host defense functions of IL-32 in tuberculosisEdward D Chan; Fiscal Year: 2013..Additionally, enhancing the bioactivity of IL-32 should increase induction of PCD and MTB killing. ..
- Molecular mechanisms of pathogen recognition by the Nod-like receptor NLRC4Fayyaz S Sutterwala; Fiscal Year: 2012..iii) Determining if NLRC4 recognizes host plasma membrane components following their disruption by bacterial T3SS. ..
- ROS, Inflammation, and Cardioprotection in Type 2 DiabetesRakesh C Kukreja; Fiscal Year: 2013..Overall, the proposed studies will pave the way to a potentially novel pharmacotherapy against inflammation and cardiac injuries resulting from T2D conditions. ..
- Role of Interleukin-1 in mediating epithelial-dendritic cell crosstalk in the lunBART N contact LAMBRECHT; Fiscal Year: 2010..This project will help unravel how individuals become allergic when exposed to house dust mite allergen. ..
- Regulation of caspase-1 by Sod2 in the heartKumuda C Das; Fiscal Year: 2010..The outcome of these studies may help in the therapeutic use of MnSOD or substances that induce MnSOD in the protection of myocardial injury in heart failure, endothelial dysfunction or other cardiovascular diseases. ..
- Neutrophil Accumulation in Bacterial PneumoniaSamithamby Jeyaseelan; Fiscal Year: 2013....
- Inflammasome Activation in Complex Regional Pain SyndromeWade S Kingery; Fiscal Year: 2013....
- Inflammasome activation by a respiratory virusChristopher M Wiethoff; Fiscal Year: 2010....
- Gender-Specific Role of Aim2 in Inflammation and AutoimmunityDivaker Choubey; Fiscal Year: 2011..Moreover, our studies will help in the rational design of new therapies and treatments for chronic inflammatory diseases, including systemic lupus erythematosus (SLE). ..
- ERK Signaling in Inflammatory Bone LossFrancis Young In Lee; Fiscal Year: 2013..Overall impact is high in that we expect to unravel novel anti-osteoclastogenic mechanisms and therapeutic promise of rhCRG in the context of inflammatory osteolysis. ..
- Cryopyrin/NLRP3 Signaling in Inflammation and Innate ImmunityGabriel Nunez; Fiscal Year: 2013..These studies may lead to better understanding of mechanisms that control host defense against human pathogens and the pathogenesis of inflammatory disease. ..
- Inflammasomes in pathogenesis of mesotheliomaArti Shukla; Fiscal Year: 2013..The goal of these studies will be to demonstrate the role of inflammasomes in MM development and may help in designing future therapeutic strategies for patients. ..
- Detection &Use of Novel Therapeutics to Stimulate NLRP3 Activity in the ElderlyHEATHER WINONA STOUT-DELGADO; Fiscal Year: 2013....
- Caspase-1 and Inflammasome Activation in Traumahemorrhagic ShockMelanie J Scott; Fiscal Year: 2013..Understanding these novel pathways of inflammatory activation and function in individual cell types and organs may help us find new ways to treat and prevent MOF in trauma patients in the future. ..
- MECHANISMS OF ACTIVATION OF ICE-LIKE CYSTEINE PROTEASESEmad S Alnemri; Fiscal Year: 2012..The results of this research will help in the design and discovery of effective therapeutics to treat inflammation associated with aging, auto-inflammatory disease and chronic inflammatory diseases. ..
- IL-1 beta Signaling in Diabetic RetinopathySusanne Mohr; Fiscal Year: 2010..These studies will clarify if the caspase-1/interleukin-1beta signaling pathway is essential for the development of diabetes-induced retinal pathology. ..
- How can caspases control intracellular pulmonary pathogensAmal O Amer; Fiscal Year: 2010..This project will help understand how bacteria establish infection, and how the host cell responds to this intracellular pathogen. Therefore, our aims will lead to better management of intracellular infections. ..
- Nlrp3 inflammasome signaling in immune responses to Candida albicansFayyaz S Sutterwala; Fiscal Year: 2013..In addition the information gained from the proposed studies will also shed light on the pathogenesis of other fungal organisms. ..
- Tim3 and Mycobacterium tuberculosisSamuel M Behar; Fiscal Year: 2013..Does IL-1 and its downstream mediators activate human MX to kill Mtb? 7 Aim 3. How does the Tim3/Gal9 interaction modulate immunity to tuberculosis in vivo? ..
- Innate Immune Activation in MalariaDouglas T Golenbock; Fiscal Year: 2013..Gallego spends in South America will increase, with the ultimate goal of exporting cutting edge technology and expertise to the scientific community in Colombia. ..
- Development of inlammasome inhibitors to be used as anti-inflammatory agentsShyam Biswal; Fiscal Year: 2013..Successful completion of the proposed study will yield novel compounds that inhibit the inflammasome in cell-based systems. ..
- Effects of a chlamydial ATP-consuming enzyme on the inflammasomeMARIA LUISA AVILA; Fiscal Year: 2010..Investigate the ability of cNdk to modulate the activity of the Nalp3/Cryopyrin inflammasome in cells stimulated with microbial products. ..
- Cysteine Proteases in ApoptosisEmad S Alnemri; Fiscal Year: 2012..The results of this research will help in the design and discovery of effective therapeutics to treat autoinflammatory diseases. ..
- Inflammasome Danger Signaling:A Novel Target to Prevent Debris Induced OsteolysisNadim James Hallab; Fiscal Year: 2013..e. from initial lysosomal destabilization and NADPH oxidase induction of ROS, to NALP3-ASC oligomerization, and Caspase 1 conversion of pro-IL-1 to IL-1...
- Role of the inflammasome in hepatitis C virus pathogenesisGulam Waris; Fiscal Year: 2012..In addition, it is expected that the results will fundamentally advance the fields of liver inflammation and lipid metabolism mediated by HCV-infection. ..
- Impact of CR on inflammasome driven immune-metabolic interactions.Vishwa Deep Dixit; Fiscal Year: 2013....
- Inflammasome regulation after spinal cord injuryRobert W Keane; Fiscal Year: 2012..The development of new treatments that can be given in the first hours after SCI may prevent or reverse much of the spinal cord damage resulting from SCI with a goal of restoring normal functioning in behavior. ..
- Inflammasome Response to Bacterial InfectionEdward A Miao; Fiscal Year: 2013..Our results will be instructive for designing live attenuated vaccines as well as vaccine adjuvants. The general mechanisms revealed by these studies will also facilitate the understanding of inflammatory disease. ..
- Innate Immune Sensing of Bacterial SugarsDavid M Underhill; Fiscal Year: 2013..In aim three well will explor how the Gram-positive peptidoglycan recycling system can be manipulated to influence signaling by this pathway in immune cells and alter microbial pathogenesis. ..
- Macrophage Inflammasome RegulationMARK DAMIAN WEWERS; Fiscal Year: 2013..If confirmed, these novel hypotheses will change our concepts about IL-1[unreadable] regulation and provide new treatment options for inflammatory lung disorders. ..
- The Role of Inflammasomes in Mucosal Immunity to Intestinal Bacterial PathogensGabriel Nunez; Fiscal Year: 2013..coli, two enteric bacterial pathogens. These studies may lead to better understanding of mechanisms that control host defense against human pathogens and the pathogenesis of inflammatory disease in the intestine. ..
- Innate Immunity and Pathogen mediated Acceleration in Vascular InflammationShuang Chen; Fiscal Year: 2013..These studies thus may provide potential novel molecular targets to prevent infection-mediated disease progression. ..
- RIP2 caspase-1 signaling in macrophagesMARK DAMIAN WEWERS; Fiscal Year: 2013..abstract_text> ..
- DNA sensors and associated signaling pathways in the innate immune responseKatherine A Fitzgerald; Fiscal Year: 2013..This project will increase our understanding of how the innate immune system senses pathogens, leading to novel therapeutic targets. ..
- Modulation of Inflammasome Activation by YersiniaIgor E Brodsky; Fiscal Year: 2013..Third, we will test te hypothesis that inflammasome activation in vivo controls Yersinia infection via production of caspase-1 dependent cytokines that induce activation of specific immune cell subsets that promote bacterial clearance. ..
- Role of Mast cells in NLRP3-mediated Skin InflammationGabriel Nunez; Fiscal Year: 2013..We will use genetic and functional approaches to understand the regulation and activation of the NLRP3 inflammasome in MCs and the role of MCs in the pathogenesis of autoinflammatory disease caused by NLRP3 mutations. ..
- Regulation of Caspase-1 Signaling and Inflammation by the P2X7 ATP ReceptorGeorge R Dubyak; Fiscal Year: 2013..These studies will provide mechanistic insights that may facilitate development of adjuvant purinergic receptor-based therapies which increase the efficacy of immunogenic anti-tumor responses to primary cancer chemotherapeutic agents. ..
- Manipulation of inflammasomes and NF-kB signaling in human myeloid cells by MyxomGrant McFadden; Fiscal Year: 2013..regulate the inflammasome and NF-?B signaling pathways and test these M013 constructs in an in vivo caspase 1- dependent rat transplant vascular disease model: We will generate M013 mutants that selectively inhibit either ..
- NOD-Like Receptor Signaling is Critical to Secondhand Smoke-Induced Immunity andSanjay Batra; Fiscal Year: 2013..Unique resources include NALP12 knockout mice and human alveolar macrophages. The R15 mechanism will help to train undergraduates including minority students in the field of emerging and devastating lung diseases such as COPD/Emphysema. ..
- Pulmonary Pathogen-Recognition Pathways in MelioidosisTIMOTHY EOIN WEST; Fiscal Year: 2013..The findings may also be applicable to other respiratory infections - leading causes of death and disability worldwide that disproportionately impact the poor. ..
- NLRP1 activation induces deletion of hematopoietic progenitor cellsBEN ADAM CROKER; Fiscal Year: 2013..C. characterise the role of NLRP1 in hematopoietic stem and progenitor cells during hematopoietic stress induced by infection and chemotherapy, to understand beneficial and pathological roles for NLRP1 activation ..
- PATHOGENESIS OF FEVER IN HUMANSCHARLES ANTHONY DINARELLO; Fiscal Year: 2013..The project seeks to understand how inflammation caused by cytokines is controlled. This information will result in a better understanding of disease severity and possibly new anti-inflammatory therapies. ..
- ??PK mediated melanoma stem cell oncolysis through non-redundant programmed cellARIC G COLUNGA; Fiscal Year: 2011..The working hypothesis is that PCD induction by delta PK is augmented by autophagy and pyroptosis and delta PK infects and kills melanoma stem cells through one or more of these pathways. ..
- Cytosolic sensing of intracellular Brucella infectionRenee M Tsolis; Fiscal Year: 2013..abstract_text> ..
- Role of PISA;a PYHIN Family Member in Intracellular DNA RecognitionEicke Latz; Fiscal Year: 2013..Elucidation of molecular details of PISA activation could lead to novel strategies of pharmacological interference for diseases based on intracellular DNA recognition. ..
- Innate immune responses in keratinocytes during viral skin infectionsLiselotte E Jensen; Fiscal Year: 2013..The gained knowledge may explain mechanisms of action of therapeutic agents and will inform future drug development, including IL-36? as a novel wound healing agent. ..
- Mechanisms of CD36 Signal Transduction - Resubmission - 1Kathryn J Moore; Fiscal Year: 2013....
- Role of caspases in Legionella pneumophila pulmonary infectionAmal O Amer; Fiscal Year: 2013..This will represent a novel approach to the treatment and management of infection and inflammation in the lung. ..
- Repression of inflammasome by Francisella tularensisMeenakshi Malik; Fiscal Year: 2013..This proposal is a step ahead in understanding the immunopathogenesis of tularemia. ..
- The Role of Caspases in Warm and Cold IschemiaALKESH HARIHAR JANI; Fiscal Year: 2010..Reduced MHC expression is associated with decreased kidney graft immunogenicity and has important implications for the deleterious effect of DGF on both short and long-term allograft function. ..
- Role of PSTPIP1 in a Mouse Model of PAPA SyndromeDonghai Wang; Fiscal Year: 2012..It is thought that mutant PSTPIP1 multimerizes spontaneously, subsequently binds PYRIN, and activates caspase 1 via the adapter ASC...
- Annexin A2 and Protein p11 in Endotoxemia and SepsisKATHERINE AMBERSON HAJJAR; Fiscal Year: 2013....
- Regulation of Innate Immunity by Pyrin ProteinsJonathan A Harton; Fiscal Year: 2012..3) Establish the in vivo role of POP2 in modulating inflammatory innate immune responses. ..
- Mechanisms of Caspase-1 Mediated Schwannoma RegressionGARY JAY BRENNER; Fiscal Year: 2013....
- Inflammasomes and the mechanism of thymic demise in agingVishwa Deep Dixit; Fiscal Year: 2013..The overall goal of this project is to identify basic mechanism of thymic demise that are amenable for future clinical intervention to delay or even reverse thymic involution in middle-aged or elderly people. ..
- Inflammasome activation by cholesterol crystalsEicke Latz; Fiscal Year: 2013..abstract_text> ..
- Mechanisms of Inflammasome Inhibition by SalmonellaIgor E Brodsky; Fiscal Year: 2013..These studies will provide novel insight into a critical aspect of Salmonella-host interactions, and are likely to provide novel therapeutic targets. ..
- Phase III Trial of Minocycline in ALS:I-Clinical CenterPaul Gordon; Fiscal Year: 2007..P.I. Dr. Robert Miller). ..
- CRITICAL ROLE OF THE ASC/CASPASE-1 PATHWAY IN TICK-BORNE RICKETTSIOSESJOAO PEDRA; Fiscal Year: 2009..To accomplish these goals, Dr. Pedra will have free access to the modern facilities present at Yale University and will make use of the most current techniques available in immunobiology, microbial pathogenesis and proteomics. ..
- The role of macrophages and natural killer cells in cisplatin-induced acute renalLawrence Lu; Fiscal Year: 2007..Better understanding of the underlying inflammatory mechanisms may lead to improved preventative and treatment strategies. [unreadable] [unreadable] [unreadable]..
- Innate immune resistance to intracellular bacterial pathogensRUSSELL VANCE; Fiscal Year: 2007..Such knowledge should contribute to rational approaches to designing novel antibacterial therapies. [unreadable] [unreadable] [unreadable]..
- Viral PYRIN-only proteins as suppressors of the host immune responseChristian Stehlik; Fiscal Year: 2007..The here proposed work extends our long-term goal to define pathogen-host interactions and their effect on the immune response. [unreadable] [unreadable]..
- REGULATION OF MACROPHAGE INTERLEUKIN-1 BETA PRODUCTIONMARK WEWERS; Fiscal Year: 2006..We hypothesize that MAIL, a novel protein homologue of I-kBalpha that we discovered by yeast two-hybrid screening negatively regulates prolL-1beta processing and release. ..
- The Human Colorectal InstabilitomeStephen Meltzer; Fiscal Year: 2007..genes on protein expression and signal transduction, including phosphorylated and total SMAD2, total SMAD4, caspase 1, and TTK; 2.b...
- Interleukin-18 and Intestinal Barrier Function Following Alcohol and Burn InjuryMashkoor Choudhry; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..