cholecystokinin

Summary

Summary: A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.

Top Publications

  1. ncbi Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus
    Gregory M Sutton
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 146:3739-47. 2005
  2. doi Discovery of a cholecystokinin-gastrin-like signaling system in nematodes
    Tom Janssen
    Functional Genomics and Proteomics Unit, Department of Biology, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Endocrinology 149:2826-39. 2008
  3. ncbi Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates
    S Tanganelli
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy
    Peptides 22:1229-34. 2001
  4. ncbi Immunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala
    Franco Mascagni
    Department of Pharmacology, University of South Carolina School of Medicine, 29208, Columbia, SC, USA
    Brain Res 976:171-84. 2003
  5. pmc Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse
    Donna M Daly
    Departments of Medicine and Physiology, Gastrointestinal Diseases Research Unit GIDRU Wing, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, Canada K7L2V7
    J Physiol 589:2857-70. 2011
  6. doi Effect of age and frailty on ghrelin and cholecystokinin responses to a meal test
    Mateu Serra-Prat
    Unidad de Investigacion, Consorci Sanitari del Maresme and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Am J Clin Nutr 89:1410-7. 2009
  7. pmc Distinct subtypes of cholecystokinin (CCK)-containing interneurons of the basolateral amygdala identified using a CCK promoter-specific lentivirus
    Aaron M Jasnow
    Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Yerkes Research Center, Emory University School of Medicine, Atlanta, Georgia, USA
    J Neurophysiol 101:1494-506. 2009
  8. ncbi Two technetium-99m-labeled cholecystokinin-8 (CCK8) peptides for scintigraphic imaging of CCK receptors
    Peter Laverman
    Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Bioconjug Chem 15:561-8. 2004
  9. doi The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin
    Alice P Liou
    Digestive Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 140:903-12. 2011
  10. pmc Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex
    S M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 169:1651-61. 2010

Detail Information

Publications410 found, 100 shown here

  1. ncbi Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus
    Gregory M Sutton
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 146:3739-47. 2005
    ..phosphorylation of ERK1/2 in the solitary nucleus (NTS) is necessary for food intake suppression by exogenous cholecystokinin (CCK)...
  2. doi Discovery of a cholecystokinin-gastrin-like signaling system in nematodes
    Tom Janssen
    Functional Genomics and Proteomics Unit, Department of Biology, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Endocrinology 149:2826-39. 2008
    Members of the cholecystokinin (CCK)/gastrin family of peptides, including the arthropod sulfakinins, and their cognate receptors, play an important role in the regulation of feeding behavior and energy homeostasis...
  3. ncbi Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates
    S Tanganelli
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy
    Peptides 22:1229-34. 2001
    ....
  4. ncbi Immunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala
    Franco Mascagni
    Department of Pharmacology, University of South Carolina School of Medicine, 29208, Columbia, SC, USA
    Brain Res 976:171-84. 2003
    ..In the present study, immunohistochemical techniques were used to analyze neurons in the rat ABL that contain cholecystokinin (CCK)...
  5. pmc Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse
    Donna M Daly
    Departments of Medicine and Physiology, Gastrointestinal Diseases Research Unit GIDRU Wing, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, Canada K7L2V7
    J Physiol 589:2857-70. 2011
    ..Recordings from jejunal afferents demonstrated attenuated responses to the satiety mediators cholecystokinin (CCK, 100 nm) and 5-hydroxytryptamine (5-HT, 10 μm), as was the response to low intensity jejunal distension,..
  6. doi Effect of age and frailty on ghrelin and cholecystokinin responses to a meal test
    Mateu Serra-Prat
    Unidad de Investigacion, Consorci Sanitari del Maresme and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Am J Clin Nutr 89:1410-7. 2009
    Ghrelin and cholecystokinin (CCK) are among the peripheral signals that regulate hunger and satiety.
  7. pmc Distinct subtypes of cholecystokinin (CCK)-containing interneurons of the basolateral amygdala identified using a CCK promoter-specific lentivirus
    Aaron M Jasnow
    Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Yerkes Research Center, Emory University School of Medicine, Atlanta, Georgia, USA
    J Neurophysiol 101:1494-506. 2009
    ..b>Cholecystokinin (CCK) interneurons play critical roles in feedforward inhibition and behavioral fear responses...
  8. ncbi Two technetium-99m-labeled cholecystokinin-8 (CCK8) peptides for scintigraphic imaging of CCK receptors
    Peter Laverman
    Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Bioconjug Chem 15:561-8. 2004
    ..The present paper evaluates two (99m)Tc-labeled forms of the C-terminal octapeptide of cholecystokinin (CCK8): sulfated (s)CCK8, with high affinity for CCK1 and CCK2 receptors, and nonsulfated (ns)CCK8, with high ..
  9. doi The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin
    Alice P Liou
    Digestive Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 140:903-12. 2011
    ..I cells in the intestine secrete cholecystokinin (CCK), a peptide hormone that stimulates digestion of fat and protein, but these cells are rare and hard to ..
  10. pmc Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex
    S M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 169:1651-61. 2010
    ..which in rodents is heavily localized to the axon terminals of cortical GABA basket neurons that contain cholecystokinin (CCK)...
  11. pmc Synaptic cross talk between perisomatic-targeting interneuron classes expressing cholecystokinin and parvalbumin in hippocampus
    Miranda A Karson
    Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21210, USA
    J Neurosci 29:4140-54. 2009
    ..The prevalence of CCK and PV networks in other brain regions suggests that internetwork interactions could be generally important...
  12. pmc Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion
    Rashmi Chandra
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    J Clin Invest 123:3343-52. 2013
    b>Cholecystokinin (CCK) is a satiety hormone produced by discrete enteroendocrine cells scattered among absorptive cells of the small intestine...
  13. doi Defining the role of cholecystokinin in the lipid-induced human brain activation matrix
    Daniel J Lassman
    Gastrointestinal Sciences, University of Manchester, Salford Royal NHS Foundation Trust, Salford, United Kingdom
    Gastroenterology 138:1514-24. 2010
    In human beings, as in most vertebrates, the release of the intestinal peptide cholecystokinin (CCK) by ingested food plays a major role both in digestion and the regulation of further food intake, but the changes in brain function and ..
  14. pmc Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying
    Sara Janssen
    Department of Pathophysiology, Translational Research Center for Gastrointestinal Disorders, Catholic University of Leuven, 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 108:2094-9. 2011
    ..The delay in emptying, which was partially counteracted by ghrelin, was not mediated by cholecystokinin and GLP-1 but involved a direct inhibitory effect of T2R-agonists on gastric contractility...
  15. ncbi Peripheral interaction of ghrelin with cholecystokinin on feeding regulation
    Yukari Date
    Third Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Endocrinology 146:3518-25. 2005
    Ghrelin and cholecystokinin (CCK) are gastrointestinal hormones regulating feeding. Both transmitted via the vagal afferent, ghrelin elicits starvation signals, whereas CCK induces satiety signals...
  16. pmc Immune control of food intake: enteroendocrine cells are regulated by CD4+ T lymphocytes during small intestinal inflammation
    J R McDermott
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Gut 55:492-7. 2006
    ....
  17. ncbi C-fos protein expression in the nucleus of the solitary tract correlates with cholecystokinin dose injected and food intake in rats
    T T Zittel
    University Hospital, Department of General and Transplantation Surgery, Hoppe Seyler Str 3, University of Tubingen, Tubingen, Germany
    Brain Res 846:1-11. 1999
    C-fos protein expression was investigated in the nucleus of the solitary tract (NTS) in response to increasing cholecystokinin (CCK) doses and food intake in rats by counting the number of c-fos protein positive cells in the NTS...
  18. ncbi Anti-inflammatory effects of leptin and cholecystokinin on acetic acid-induced colitis in rats: role of capsaicin-sensitive vagal afferent fibers
    Ayhan Bozkurt
    Department of Physiology, School of Medicine, Marmara University, Haydarpasa, Istanbul, 34668, Turkey
    Regul Pept 116:109-18. 2003
    Leptin and cholecystokinin (CCK) have a synergistic interaction in the suppression of food intake, and afford similar gastroprotective activity...
  19. ncbi Parvalbumin, somatostatin and cholecystokinin as chemical markers for specific GABAergic interneuron types in the rat frontal cortex
    Yasuo Kawaguchi
    Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    J Neurocytol 31:277-87. 2002
    ..cells, (3) calretinin and/or vasoactive intestinal polypeptide (VIP) cells [partially positive for cholecystokinin (CCK)] and (4) large CCK cells (almost negative for VIP/calretinin)...
  20. doi Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion
    Svetlana Beglinger
    Division of Gastroenterology, University Hospital, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 95:879-86. 2010
    ..Glucagon-like peptide-1 (GLP-1) is produced by specialized cells in the gut and secreted in response to carbohydrates and lipids. The mechanisms regulating fat-stimulated GLP-1 release have, however, not been clarified in detail...
  21. ncbi Cholecystokinin
    Rashmi Chandra
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Endocrinol Diabetes Obes 14:63-7. 2007
    The hormone cholecystokinin was discovered in 1928 because of its ability to induce gallbladder contraction. Since then, cholecystokinin has been shown to possess multiple functions in the gastrointestinal tract and brain...
  22. ncbi Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion
    Guiyun Wang
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0725, USA
    Endocrinology 145:1342-8. 2004
    ..Additionally, the effect of apelin on cholecystokinin (CCK) secretion and the involvement of MAPK, protein kinase C, and changes in intracellular Ca(2+) in apelin-..
  23. pmc Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach
    Galina Burdyga
    Physiological Laboratory, School of Biomedical Sciences and School of Preclinical Veterinary Science, University of Liverpool, Liverpool, United Kingdom
    J Neurosci 28:11583-92. 2008
    ....
  24. pmc Presynaptic kainate receptor activation preserves asynchronous GABA release despite the reduction in synchronous release from hippocampal cholecystokinin interneurons
    Michael I Daw
    Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:11202-9. 2010
    ..Using paired recordings we show that KAR activation causes a decrease in presynaptic release from cholecystokinin (CCK)- but not parvalbumin-containing interneurons and that this decrease is observed when pyramidal cells, ..
  25. pmc Endogenous prolactin-releasing peptide regulates food intake in rodents
    Yuki Takayanagi
    Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Clin Invest 118:4014-24. 2008
    ..The peripheral satiety signal cholecystokinin is released from the gut following food intake and acts on fibers of the vagus nerve, which project to the ..
  26. ncbi Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome
    K Zwirska-Korczala
    Department of Physiology, Zabrze, Medical University of Silesia, Katowice, Poland
    J Physiol Pharmacol 58:13-35. 2007
    ..to analyze the plasma levels of total and acylated ghrelin, peptide YY(3-36) (PYY(3-36)), cholecystokinin (CCK), gastrin and insulin levels under basal conditions and in response to a standard mixed meal, and 2...
  27. doi Intestinal cholecystokinin controls glucose production through a neuronal network
    Grace W C Cheung
    Toronto General Research Institute, University Health Network, Toronto, Canada
    Cell Metab 10:99-109. 2009
    b>Cholecystokinin (CCK) is a peptide hormone that is released from the gut in response to nutrients such as lipids to lower food intake...
  28. ncbi Characterization of leptin-responsive neurons in the caudal brainstem
    Kate L J Ellacott
    Center for the Study of Weight Regulation and Associated Disorders and Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, 97239 3098, USA
    Endocrinology 147:3190-5. 2006
    ..recent studies have shown significant activation of NTS POMC-EGFP cells by the gut released satiety factor cholecystokinin (CCK)...
  29. ncbi Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor
    Natsuko Tsujino
    Department of Molecular Pharmacology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Neurosci 25:7459-69. 2005
    ..a total of 21 peptides and six other factors were examined) and found that a sulfated octapeptide form of cholecystokinin (CCK-8S), neurotensin, oxytocin, and vasopressin activate orexin neurons...
  30. ncbi Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin
    Galina Burdyga
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Neurosci 24:2708-15. 2004
    ..In the case of the satiety hormone cholecystokinin (CCK), these effects are mediated via vagal afferent neurons...
  31. pmc Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    Michael M Scott
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Clin Invest 121:2413-21. 2011
    ..Together, these data support a physiologically important role of direct leptin action in the hindbrain...
  32. ncbi Energy intake, ghrelin, and cholecystokinin after different carbohydrate and protein preloads in overweight men
    Jane Bowen
    Commonwealth Scientific and Industrial Research Organization, Human Nutrition, P O Box 10041 BC, Adelaide SA 5000, Australia
    J Clin Endocrinol Metab 91:1477-83. 2006
    ..Dietary proteins appear to be more satiating than carbohydrate. The mechanism and effect of protein and carbohydrate type are unclear...
  33. ncbi Interneuron Diversity series: Rhythm and mood in perisomatic inhibition
    Tamas F Freund
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, PO Box 67, H 1450, Hungary
    Trends Neurosci 26:489-95. 2003
    ..By contrast, a highly modifiable interneuron syncytium containing cholecystokinin carries information from subcortical pathways about the emotional, motivational and general physiological ..
  34. ncbi 5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons
    Isabelle Ferezou
    Laboratoire de Neurobiologie et Diversité Cellulaire, Centre National de la Recherche Scientifique, Unité Mixte de Rechérche 7637, Ecole Superieure de Physique et Chime Industrielles de la ville de Paris, 75005 Paris, France
    J Neurosci 22:7389-97. 2002
    ..The 5-HT3A receptor subunit was expressed selectively in a subset of GABAergic interneurons coexpressing cholecystokinin (CCK) and vasoactive intestinal peptide (VIP)...
  35. ncbi GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat
    Jozsef Somogyi
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, UK
    Eur J Neurosci 19:552-69. 2004
    ..The presumed amino acid substrate of VGLUT3 may act on presynaptic kainate or group II metabotropic glutamate receptors...
  36. ncbi Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus
    Suzanne M Appleyard
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 27:13292-302. 2007
    ..The satiety peptide, cholecystokinin, presynaptically facilitated glutamate transmission in one-half of NTS CA neurons...
  37. ncbi Effect of a high-protein breakfast on the postprandial ghrelin response
    Wendy A M Blom
    TNO Quality of Life, Zeist, Netherlands
    Am J Clin Nutr 83:211-20. 2006
    ..The most satiating macronutrient appears to be dietary protein. Few studies have investigated the effects of dietary protein on ghrelin secretion in humans...
  38. pmc Functional characteristics of parvalbumin- and cholecystokinin-expressing basket cells
    Marlene Bartos
    Physiologisches Institut I, Albert Ludwigs Universitat Freiburg, Hermann Herder Straße 7, 79104 Freiburg, Germany
    J Physiol 590:669-81. 2012
    ..the signalling properties of two major types of perisomatic inhibitory interneurons, the parvalbumin- and the cholecystokinin-containing basket cells...
  39. ncbi Free fatty acids induce cholecystokinin secretion through GPR120
    Toshiki Tanaka
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto, 606 8501, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:523-7. 2008
    The ingestion of fat induces secretion of the gut peptide hormone cholecystokinin (CCK); however, the mechanism responsible for lipid-induced CCK release remains unknown...
  40. pmc Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of ΔFosB
    Vincent Vialou
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, Department of Physiology, Michigan State University, Lansing, Michigan 48824, Department of Pharmacology and Toxicology, University of Buffalo, Buffalo, New York 14214, Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada, Department of Psychiatry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, and Institut National de la Sante et de la Recherche Medicale, U1130, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8246, and Universite Pierre et Marie Curie, UM CR18, Sorbonne Université, Paris, France
    J Neurosci 34:3878-87. 2014
    ..FosB produced these effects partly through induction of the cholecystokinin (CCK)-B receptor: CCKB blockade in mPFC induces a resilient phenotype, whereas CCK administration into mPFC ..
  41. pmc Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability
    Pan Yue Deng
    Department of Pharmacology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58203, USA
    J Neurosci 30:5136-48. 2010
    b>Cholecystokinin (CCK), a neuropeptide originally discovered in the gastrointestinal tract, is abundantly distributed in the mammalian brains including the hippocampus...
  42. doi Cardiovascular and inflammatory response to cholecystokinin during endotoxemic shock
    Rafael Simone Saia
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirao Preto, Sao Paulo, Brazil
    Shock 39:104-13. 2013
    b>Cholecystokinin (CCK) was first described as a gastrointestinal hormone, but its receptors have been located in cardiac and vascular tissues, as well as in immune cells...
  43. pmc Gastric expression of plasminogen activator inhibitor (PAI)-1 is associated with hyperphagia and obesity in mice
    Susan Kenny
    Departments of Cell and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Endocrinology 154:718-26. 2013
    ..In the latter, food intake was inhibited by cholecystokinin (CCK)8s, but PAI-1-H/Kβ mice were insensitive to the satiating effects of CCK8s...
  44. ncbi Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion
    Yan Bi
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA
    Am J Physiol Gastrointest Liver Physiol 289:G561-70. 2005
    ....
  45. doi Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men
    Ixchel M Brennan
    University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
    Am J Physiol Gastrointest Liver Physiol 303:G129-40. 2012
    ..In conclusion, HP meals suppress energy intake in lean and obese subjects, an effect potentially mediated by CCK and ghrelin, while obese individuals appear to be less sensitive to the satiating effects of fat...
  46. ncbi Cholecystokinin and gastrin receptors
    Marlene Dufresne
    Institut National de la Santé et de la Recherche Médicale U 531, Institut Louis Bugnard, Centre Hospitalier Universitaire Rangueil, France
    Physiol Rev 86:805-47. 2006
    b>Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled receptors that have been the subject of intensive research in the last 10 years with corresponding advances in the understanding of their functioning and ..
  47. ncbi Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus
    L Rinaman
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Physiol 277:R582-90. 1999
    ..These results suggest that GLP-1 neurons are uniquely activated in situations of interoceptive stress, and may participate in adaptive hypothalamic stress responses...
  48. pmc Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti-inflammatory effect of cholecystokinin
    Satoshi Miyamoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Diabetes 61:897-907. 2012
    Inflammatory process is involved in the pathogenesis of diabetic nephropathy. In this article, we show that cholecystokinin (CCK) is expressed in the kidney and exerts renoprotective effects through its anti-inflammatory actions...
  49. pmc Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats
    Guillaume de Lartigue
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e32967. 2012
    The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size and duration by activating CCK1 receptors on vagal afferent neurons (VAN)...
  50. pmc Effects of cholecystokinin in the supraoptic nucleus and paraventricular nucleus are negatively modulated by leptin in 24-h fasted lean male rats
    C Caquineau
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    J Neuroendocrinol 22:446-52. 2010
    b>Cholecystokinin (CCK) and leptin are two important satiety factors that are considered to act in synergy to reduce meal size...
  51. ncbi Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis
    Anna S Gukovskaya
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and the UCLA, Los Angeles, California 90073, USA
    J Biol Chem 277:22595-604. 2002
    ..Many characteristics of pancreatitis can be studied in vitro in pancreatic acini treated with high doses of cholecystokinin (CCK)...
  52. ncbi Elevated plasma cholecystokinin at high altitude: metabolic implications for the anorexia of acute mountain sickness
    D M Bailey
    Health and Exercise Sciences Research Laboratory, School of Applied Sciences, University of Glamorgan, Pontypridd, United Kingdom
    High Alt Med Biol 1:9-23. 2000
    The aims of the present study were to measure the satiety neuropeptide cholecystokinin (CCK) in humans at terrestrial high altitude to investigate its possible role in the pathophysiology of anorexia, cachexia, and acute mountain ..
  53. pmc Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y
    Mallory E Bowers
    Center for Behavioral Neuroscience, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States
    Physiol Behav 107:699-710. 2012
    ..The cholecystokinin (CCK) system initially led to much excitement through its potential role in panic disorder...
  54. ncbi Prolactin-releasing Peptide mediates cholecystokinin-induced satiety in mice
    David A Bechtold
    Faculty of Life Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Endocrinology 147:4723-9. 2006
    ..Here we examine the effects of PrRP and cholecystokinin (CCK) on feeding in mice, including PrRP receptor gene knockout animals (GPR10(-/-))...
  55. pmc Molecular and electrophysiological characterization of GFP-expressing CA1 interneurons in GAD65-GFP mice
    Corette J Wierenga
    Department of Cellular and Systems Neurobiolgy, Max Planck Institute of Neurobiology, Martinsried, Germany
    PLoS ONE 5:e15915. 2010
    ..can be subdivided according to the (partially overlapping) expression of neuropeptide Y (42±3%), cholecystokinin (25±3%), calbindin (20±2%) or calretinin (20±2%)...
  56. ncbi Cholecystokinin affects gastric emptying and stomach motility in the rainbow trout Oncorhynchus mykiss
    C Olsson
    Department of Zoophysiology, University of Goteborg, Box 463, S 405 30 Goteborg, Sweden and Department of Radiation Physics, Sahlgrenska Hospital, Goteborg, Sweden
    J Exp Biol 202:161-70. 1999
    ..Using these methods, we investigated the effects of the sulphated octapeptide of cholecystokinin (CCK8) on gastric emptying and on stomach motility in vivo and in vitro...
  57. pmc Cocaine- and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons
    Guillaume de Lartigue
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    Gastroenterology 138:1479-90. 2010
    b>Cholecystokinin (CCK) acts on vagal afferent neurons to inhibit food intake and gastric emptying; it also increases expression of the neuropeptide cocaine- and amphetamine-regulated transcript (CART), but the significance of this is ..
  58. pmc EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons
    Guillaume de Lartigue
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    Endocrinology 151:3589-99. 2010
    ..Food intake is regulated by signals from peripheral organs, but the way these are integrated remains uncertain. Cholecystokinin (CCK) from the intestine and leptin from adipocytes interact to inhibit food intake...
  59. doi Cholecystokinin
    Graham J Dockray
    Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
    Curr Opin Endocrinol Diabetes Obes 19:8-12. 2012
    b>Cholecystokinin (CCK) controls nutrient delivery to the small intestine by inhibiting food intake and gastric emptying. This review deals with recent work shedding new light on how and when.
  60. pmc Mechanisms of CCK signaling from gut to brain
    Helen E Raybould
    Department of Vet Med Anatomy, Physiology and Cell Biology APC, UC Davis School of Veterinary Medicine, Davis, CA 95616, USA
    Curr Opin Pharmacol 7:570-4. 2007
    ..In addition, new evidence showing the importance of the action of CCK at the level of the vagus nerve in the regulation of food intake, body weight, and in activation of an anti-inflammatory pathway will be reviewed...
  61. ncbi Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations
    Supornpim Chearskul
    Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Am J Clin Nutr 87:1238-46. 2008
    ..Weight regain after weight loss may not be due primarily to voluntary return to social habits but may be explained by changes in peripheral hormonal signals activating hunger and encouraging feeding behavior...
  62. doi Cholecystokinin and gut-brain signalling
    Graham J Dockray
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown St, Liverpool L69 3BX, UK
    Regul Pept 155:6-10. 2009
    ..The intestinal hormone cholecystokinin (CCK) stimulates vagal afferent neuron discharge and also controls the expression of both G-protein coupled ..
  63. pmc Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network
    Wen Hu
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
    Neuropsychopharmacology 35:1693-707. 2010
    ..and network function focusing on two perisomatic interneurons, the parvalbumin (PV)- and the cholecystokinin (CCK)-positive neurons...
  64. ncbi Delta-opioid receptor-mediated increase in cortical extracellular levels of cholecystokinin-like material by subchronic morphine in rats
    C Becker
    INSERM U 288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, C H U Pitiè Salpêtrière, Paris, France
    Neuropharmacology 39:161-71. 2000
    Numerous pharmacological data indirectly support the idea that interactions between cholecystokinin (CCK) and opioids participate in the development of tolerance to morphine...
  65. pmc Cholecystokinin facilitates neuronal excitability in the entorhinal cortex via activation of TRPC-like channels
    Shouping Wang
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA
    J Neurophysiol 106:1515-24. 2011
    b>Cholecystokinin (CCK) is one of the most abundant neuropeptides in the brain, where it interacts with two G protein-coupled receptors (CCK-1 and CCK-2)...
  66. pmc Cholinergic modulation amplifies the intrinsic oscillatory properties of CA1 hippocampal cholecystokinin-positive interneurons
    Christian A Cea-Del Rio
    Program in Developmental Neurobiology, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, Bethesda, MA 20892, USA
    J Physiol 589:609-27. 2011
    ..We show that two types of cholecystokinin-positive local circuit inhibitory interneuron, the so-called 'basket cells' and 'Schaffer collateral-..
  67. ncbi Cholecystokinin antagonists: pharmacological and therapeutic potential
    Rosario Herranz
    Instituto de Quimica Medica CSIC, Juan de la Cierva 3, E 28006 Madrid, Spain
    Med Res Rev 23:559-605. 2003
    b>Cholecystokinin (CCK) is a regulatory peptide hormone, predominantly found in the gastrointestinal tract, and a neurotransmitter present throughout the nervous system...
  68. ncbi Neural basis for the hyperalgesic action of cholecystokinin in the rostral ventromedial medulla
    Mary M Heinricher
    Dept Neurological Surgery, L 472, Oregon Health and Science Univ, Portland, OR 97239, USA
    J Neurophysiol 92:1982-9. 2004
    The analgesic actions of opioids can be modified by endogenous "anti-opioid" peptides, among them cholecystokinin (CCK)...
  69. ncbi Cholecystokinin is necessary for the expression of morphine conditioned place preference
    Jennifer M Mitchell
    Department of Neurology, Box 0114, University of California at San Francisco, San Francisco, CA 94143, USA
    Pharmacol Biochem Behav 85:787-95. 2006
    There is evidence that the neuropeptide cholecystokinin (CCK) is important for the rewarding effects of drugs of abuse. However, less is known regarding the role of CCK in drug seeking and craving...
  70. pmc Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats
    Josimari M Desantana
    Department of Physical Therapy, Federal University of Sergipe, Av Marechal Rondon, S N, Jardim Rosa Elze, Sao Cristovao, Sergipe CEP 49100 000, Aracaju, Brazil
    Pain 148:84-93. 2010
    ..Prior pharmacological studies show that blockade of cholecystokinin (CCK) receptors systemically and spinally prevents the development of analgesic tolerance to repeated doses ..
  71. doi Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men
    Jessica E Stewart
    University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, Australia
    Am J Clin Nutr 93:703-11. 2011
    ..Both orosensory stimulation and feedback from the gastrointestinal tract contribute to energy intake regulation...
  72. ncbi Cholecystokinin and peptide Y in yellowtail (Seriola quinqueradiata): molecular cloning, real-time quantitative RT-PCR, and response to feeding and fasting
    Koji Murashita
    Faculty of Agriculture, Kochi University, B200 Monobe, Nankoku, Kochi 783 8502, Japan
    Gen Comp Endocrinol 145:287-97. 2006
    In fish, the peptide hormones cholecystokinin (CCK) and peptide Y (PY) may be involved in pancreatic exocrine secretion, as found with mammalian CCK and peptide YY (PYY); CCK stimulates, whereas PYY inhibits, pancreatic exocrine ..
  73. pmc Role of endogenous cholecystokinin on growth of human pancreatic cancer
    Gail L Matters
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 38:593-601. 2011
    b>Cholecystokinin (CCK) and gastrin stimulate growth of pancreatic cancer. Although down-regulation of gastrin inhibits growth of pancreatic cancer, the contribution of endogenous CCK to tumor growth is unknown...
  74. doi Ghrelin, cholecystokinin, and peptide YY in Atlantic salmon (Salmo salar): molecular cloning and tissue expression
    Koji Murashita
    Tohoku National Fisheries Research Institute, Fisheries Research Agency, Shiogama, Miyagi, Japan
    Gen Comp Endocrinol 160:223-35. 2009
    Gastrointestinal (GI) peptide hormones, ghrelin (GHRL), cholecystokinin (CCK), and peptide YY (PYY) genes were identified in Atlantic salmon, Salmo salar...
  75. ncbi Cholecystokinin and GABA interaction in the dorsal hippocampus of rats in the elevated plus-maze test of anxiety
    Mehdi Rezayat
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Physiol Behav 84:775-82. 2005
    ..In conclusion, it seems that both CCK and GABAergic systems not only play a part in the modulation of anxiety in the dorsal hippocampus of rats but also have demonstrated a complex interaction as well...
  76. ncbi Cooperative activation of cultured vagal afferent neurons by leptin and cholecystokinin
    J H Peters
    Department of Veterinary and Comparative Anatomy, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 6520, USA
    Endocrinology 145:3652-7. 2004
    ..previously reported, about 35% of vagal afferents increase cytosolic calcium in response to the gut-peptide cholecystokinin (CCK)...
  77. ncbi Adaptation to a high-fat diet leads to hyperphagia and diminished sensitivity to cholecystokinin in rats
    David M Savastano
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, University Park, 16802 6504, USA
    J Nutr 135:1953-9. 2005
    ..1%, LF = 68.1%, P = 0.29). Finally, we examined the effect of intraperitoneal NaCl or cholecystokinin (CCK)-8 (100 and 250 ng/kg) injection on 1-h food intake...
  78. ncbi Physiological phenotyping of cholecystokinin-responsive rat taste receptor cells
    Shao gang Lu
    Section of Oral Biology, College of Dentistry, The Ohio State University, 305 West 12th Avenue, Columbus, OH 43210, USA
    Neurosci Lett 351:157-60. 2003
    The recent discovery that subsets of rat taste receptor cells (TRCs) express the peptide cholecystokinin (CCK) and that subsets of TRCs respond to CCK with altered potassium currents or elevated intracellular calcium via CCK-A receptor ..
  79. doi Stabilized (111)in-labeled sCCK8 analogues for targeting CCK2-receptor positive tumors: synthesis and evaluation
    Susan Roosenburg
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    Bioconjug Chem 21:663-70. 2010
    Radiolabeled cholecystokinin-8 (CCK8) peptide analogues can be used for peptide receptor radionuclide imaging and therapy for tumors expressing CCK2/gastrin receptors...
  80. ncbi Appetite regulatory hormone responses to various dietary proteins differ by body mass index status despite similar reductions in ad libitum energy intake
    Jane Bowen
    Department of Human Nutrition, Commonwealth Scientific and Industrial Research Organisation, Adelaide SA 5000, Australia
    J Clin Endocrinol Metab 91:2913-9. 2006
    ..Although dietary protein produces higher acute satiety relative to carbohydrate, the influence of protein source and body mass index (BMI) has not been clearly described...
  81. ncbi Sex-specific patterns of galanin, cholecystokinin, and substance P expression in neurons of the principal bed nucleus of the stria terminalis are differentially reflected within three efferent preoptic pathways in the juvenile rat
    Eva K Polston
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Comp Neurol 465:551-9. 2003
    ..The neuropeptides galanin (GAL), cholecystokinin (CCK), and substance P (SP) are highly expressed in BSTp neurons and are differentially regulated by sex ..
  82. doi Differential feeding behavior and neuronal responses to CCK in obesity-prone and -resistant rats
    T D Swartz
    Interdepartmental Graduate Degree Program in Physiology, Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Brain Res 1308:79-86. 2010
    ..One such satiation signal is cholecystokinin (CCK), whose effects on food intake are diminished in animals adapted to a high fat diet...
  83. pmc Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy
    Megan S Wyeth
    Departments of Neurobiology and Neurology and Physiology, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:8993-9006. 2010
    ..Two major subclasses of CA1 basket cells can be identified based on their expression of either cholecystokinin (CCK) or parvalbumin...
  84. ncbi Activation of CB1 cannabinoid receptors in rat hippocampal slices inhibits potassium-evoked cholecystokinin release, a possible mechanism contributing to the spatial memory defects produced by cannabinoids
    M C Beinfeld
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Neurosci Lett 301:69-71. 2001
    Cannabinoid use is known to disrupt learning and memory in a number of species. cholecystokinin (CCK) release and CCK receptors have been implicated in spatial memory processes in rodents...
  85. ncbi Characterization of mice lacking the gene for cholecystokinin
    Chun Min Lo
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Genome Research Institute, 2120 E Galbraith Rd, Bldg A, ML 0507, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 294:R803-10. 2008
    ..We conclude that CCK is involved in metabolic rate and is important for memory and exploration. CCK is intimately involved in multiple processes related to cognitive function and food intake regulation...
  86. ncbi Expression of the leptin receptor in rat and human nodose ganglion neurones
    G Burdyga
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Neuroscience 109:339-47. 2002
    There is evidence for interactions between leptin and cholecystokinin in controlling food intake. Since cholecystokinin acts on vagal afferent neurones, we asked whether the leptin receptor was also expressed by these neurones...
  87. ncbi TRPA1 channel activation induces cholecystokinin release via extracellular calcium
    A K Purhonen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    FEBS Lett 582:229-32. 2008
    ..of STC-1 cells with AITC increased intracellular calcium ([Ca(2+)](i)) and significantly stimulated cholecystokinin secretion by 6.7-fold...
  88. ncbi Cholecystokinin, glucose dependent insulinotropic peptide and glucagon-like peptide 1 secretion in children with anorexia nervosa and simple obesity
    Przemyslaw J Tomasik
    Department of Clinical Biochemistry, University Children s Hospital, Jagiellonian University, Krakow, Poland
    J Pediatr Endocrinol Metab 17:1623-31. 2004
    b>Cholecystokinin (CCK), glucose dependent insulinotropic peptide (GIP), and glucagon-like peptide 1 (GLP-1) regulate satiety as enterogastrons and incretins. They also directly affect the satiety centers...
  89. ncbi Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance
    Jennifer Y Xie
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    J Neurosci 25:409-16. 2005
    ..Here, we investigate the possibility that cholecystokinin (CCK), a pronociceptive peptide, may drive such descending facilitation from the RVM during continuous opioid ..
  90. pmc Persistently active cannabinoid receptors mute a subpopulation of hippocampal interneurons
    Attila Losonczy
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony Street, 1083, Budapest, Hungary
    Proc Natl Acad Sci U S A 101:1362-7. 2004
    ..In paired recordings between cholecystokinin-immunopositive, mossy fiber-associated INs, and their target CA3 pyramidal cells, no postsynaptic currents ..
  91. pmc The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight
    A S Kopin
    Department of Medicine, GRASP Digestive Disease Center, Tupper Research Institute, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Clin Invest 103:383-91. 1999
    ..To elucidate the contribution of the endogenous peptide cholecystokinin, mice lacking functional cholecystokinin-A receptors were generated by targeted gene disruption...
  92. ncbi Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin
    C Becker
    Faculte de Medecine Pierre et Marie Curie, UMR 713 INSERM UPMC, Douleurs et Stress, Paris Cedex, France
    Mol Psychiatry 13:1079-92. 2008
    b>Cholecystokinin (CCK) involvement in depression-like disorders is poorly documented...
  93. ncbi Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans
    Christine Feinle
    University of Adelaide Department of Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
    Am J Physiol Gastrointest Liver Physiol 284:G798-807. 2003
    ..05). In conclusion, lipase inhibition attenuates the effects of duodenal fat on antropyloroduodenal motility, appetite, and CCK and glucagon-like peptide-1 secretion...
  94. pmc Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independent
    Michael I Daw
    Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:11112-22. 2009
    ..Here, we show that three classes of depolarization-induced suppression of inhibition-expressing, cholecystokinin (CCK)-containing, hippocampal interneurons show highly asynchronous release in response to trains of action ..
  95. ncbi Gastrointestinal satiety signals II. Cholecystokinin
    Timothy H Moran
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205, USA
    Am J Physiol Gastrointest Liver Physiol 286:G183-8. 2004
    ..CCK plays a variety of roles in coordinating gastrointestinal activity and has been demonstrated to be an important mediator for the control of meal size...
  96. ncbi Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids
    Suzanne M Appleyard
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 25:3578-85. 2005
    ..Intraperitoneal administration of cholecystokinin (CCK) induced c-fos gene expression in NTS POMC-EGFP neurons, suggesting that they are activated by afferents ..
  97. ncbi PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
    M F Offield
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 122:983-95. 1996
    ..These results offer additional insight into the role of pdx-1 in the determination and differentiation of the posterior foregut, particularly regarding the proliferation and differentiation of the pancreatic progenitors...
  98. ncbi Deficits in E2-dependent control of feeding, weight gain, and cholecystokinin satiation in ER-alpha null mice
    N Geary
    Bourne Behavioral Research Laboratory, Department of Psychiatry, New York Presbyterian Hospital Weill Medical College of Cornell University, White Plains, New York 10605, USA
    Endocrinology 142:4751-7. 2001
    ..Because an increase in the potency of the peripheral cholecystokinin (CCK) satiation-signaling system mediates part of E2's influence on feeding in rats, the influence of ip ..
  99. doi Oat beta-glucan increases postprandial cholecystokinin levels, decreases insulin response and extends subjective satiety in overweight subjects
    Eleanor J Beck
    School of Health Sciences, University of Wollongong, Wollongong, Australia
    Mol Nutr Food Res 53:1343-51. 2009
    ..Blood was collected to measure glucose, insulin, ghrelin and cholecystokinin, and visual analogue scales measured subjective satiety...
  100. pmc The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism
    Francesco Rubino
    IRCAD EITS, Strasbourg, France
    Ann Surg 240:236-42. 2004
    ..We speculated that if the mechanism of action of the RYGB involves an endocrine effect, then hormonal changes should occur early after surgery, prior to substantial body weight changes...
  101. ncbi Plasma hormone levels and central c-Fos expression in ferrets after systemic administration of cholecystokinin
    I Billig
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1243-55. 2001
    ....

Research Grants64

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. In vivo targeted gene silencing, a novel method
    WILLIAM ANTHONY TRUITT; Fiscal Year: 2012
    ..represent a subpopulation of BLA-interneurons that contain the neuropeptides somatostatin (Sst) and cholecystokinin (Cck), and although these cells appear to be pivotal in the regulation of anxiety-like responses, the ..
  3. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..the influence of these specific neuropeptides (vasoactive intestinal peptide (VIP), substance P (SP), and cholecystokinin (CCK)) on synaptic transmission in thalamocortical circuits...
  4. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..The work will focus on pyramidal cells, PV+ cells, cholecystokinin-expressing (CCK+) cells and somatostatin-containing (SOM+) interneurons...
  5. Regulation of Hepatic Uptake of Endogenous Signaling Molecules and Xenobiotics
    Ivan Csanaky; Fiscal Year: 2013
    ..important endogenous molecules, such as unconjugated hydrophilic bile acids, bilirubin, a peptide hormone cholecystokinin-8, and prostaglandin E2 (PGE2)...
  6. Cholecystokinin - Role in postprandial gastric motility
    Helen E Raybould; Fiscal Year: 2013
    ....
  7. Physiology and regulation of T2R bitter taste receptors in enteroendocrine cells
    Timothy F Osborne; Fiscal Year: 2013
    ..showed that activation of intestinal T2R signaling leads to an increase in secretion of polypeptide hormones cholecystokinin (CCK) and glucagon-like-peptide-1 (GLP-1) from enteroendocrine cells and two major actions of CCK are to ..
  8. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
    ..determine the influence of these neuropeptides (vasoactive intestinal peptide (VIP), substance P (SP), and cholecystokinin (CCK)) on synaptic transmission in thalamocortical circuits...
  9. Live imaging of brain circuitry in mouse models of PTSD
    Elaine L Bearer; Fiscal Year: 2013
    ..To reveal whether SERT mutants affect a common neural network, cholecystokinin knock-out mice with a behavioral phenotype similar to SERT mutants will be imaged and analyzed in parallel...
  10. Intralumental Effect on Cholesterol Absorption/Synthesis
    James Heubi; Fiscal Year: 2009
    ..are related to changes in pool size and intestinal transit or meal stimulated gall bladder emptying or plasma cholecystokinin levels...
  11. In Vivo Brain Dialysis of Neuropeptides and Neuroimmune Signaling Proteins
    Julie A Stenken; Fiscal Year: 2012
    ..MIP-12], CCL5 [RANTES], KC/GRO, IL-1b, IL-6, IL-10, and TNF-a} and neuropeptides {angiotensin IV, 2-amyloid, cholecystokinin, corticotropin releasing hormone, and neuropeptide Y)...
  12. Regulation of Cholinergic Transmission and Theta Rhythms by Endocannabinoids
    DANIEL ALAN NAGODE; Fiscal Year: 2012
    ..Prior evidence shows that GABAergic interneurons in the hippocampus that co-express the neuropeptide cholecystokinin (CCK+ interneurons), also highly express cholinergic receptors, can release endocannabinoids, and may be ..
  13. Regulation of Food Intake and Body Weight by GLP-1
    ROGER REIDELBERGER; Fiscal Year: 2010
    ..anorexigenic GLP-1 form(s) act synergistically with other putative satiety and adiposity regulatory factors [cholecystokinin, amylin, oxyntomodulin, peptide YY(3-36), leptin] to reduce food intake...
  14. Receptor Regulation of CCK Cell Function
    Rodger A Liddle; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cholecystokinin (CCK) is a major gastrointestinal hormone that is produced by discrete enteroendocrine cells (known as I cells) that are scattered throughout the intestine...
  15. RENAL DOPAMINE-1 RECEPTOR DEFECT IN HYPERTENSION
    Pedro A Jose; Fiscal Year: 2013
    ..a meal with Na+ gastrin is released into the circulation, and taken up by renal tubules where it acts on cholecystokinin B receptors (CCKBRs) to decrease Na+ transport...
  16. Brainstem LepRb neurons in the control of metabolism
    JONATHAN NICHOLAS FLAK; Fiscal Year: 2013
    ..We found that many PAG/lPBN LepRb neurons contain the neuropeptide, cholecystokinin (CCK), and that the distribution of these LepRbCCK neurons is restricted to the brainstem...
  17. Novel Nanoparticle Therapy for Pancreatic Cancer
    Mark Kester; Fiscal Year: 2013
    ..We have identified a membrane bound growth receptor in human pancreatic cancer cells called the cholecystokinin or CCK- receptor...
  18. Endocannabinoid and Cholecystokinin Interactions Mediating Extinction Learning
    Mallory Bowers; Fiscal Year: 2013
    ..In a separate study in or laboratory, the neuropeptide cholecystokinin (CCK) also seems to be involved in extinction learning, as animals treated with the CCK-B receptor agonist, ..
  19. STUDIES IN GASTROINTESTINAL ENDOCRINOLOGY
    Mark R Hellmich; Fiscal Year: 2010
    ..In Project 2, we will continue our studies on the signal mechanisms that regulate intestinal cholecystokinin (CCK) secretion by studies on the recently discovered peptide, apelin...
  20. NEURAL SUBSTRATES OF PEPTIDE INDUCED SATIETY
    Robert C Ritter; Fiscal Year: 2012
    ..goal of this work is to define the neural mechanisms through which gastrointestinal hormones, especially cholecystokinin (CCK) and glucagon-related peptide (CCK), control food intake and to appreciate how these substrates are ..
  21. Role of Oxytocin Signaling in the Pathogenesis of Diet-Induced Obesity
    JAMES ERNEST BLEVINS; Fiscal Year: 2013
    ..the behavioral effects and hindbrain neuronal activation produced by meal-related satiety signals, such as cholecystokinin (CCK), are altered in states of diet-induced obesity (DIO)...
  22. NUCLEUS TRACTUS SOLITARIUS MELANOCORTIN SIGNALING IN THE CONTROL OF FOOD INTAKE
    SCOTT EDWARD KANOSKI; Fiscal Year: 2012
    ..MC4-R ligands, and that caudal brainstem MC4-R signaling is required for food intake suppression by exogenous cholecystokinin (CCK), the intestinally-derived satiation hormone...
  23. Physiological correlates of endogenous pain modulation in healthy individuals and
    Christopher D King; Fiscal Year: 2013
    ..e., endogenous opioids, cholecystokinin) and psychological (i.e., catastrophizing) responses to pain...
  24. Mechanisms Regulating Gastrointestinal Hormone Secretion
    Rodger A Liddle; Fiscal Year: 2013
    ..b>Cholecystokinin (CCK) is a prototypical gastrointestinal hormone that regulates gallbladder contraction, pancreatic enzyme ..
  25. Integration of Peripheral and Central Appetite Signals by Brainstem Neurons
    Suzanne M Appleyard; Fiscal Year: 2013
    ..catecholamines (NTS-CA neurons) disrupts control of food intake by several hormones, including ghrelin and cholecystokinin (CCK)...
  26. Regulation of synaptic plasticity by eCBs in adult and aged mammalian cortex
    Karen L Montey; Fiscal Year: 2012
    ..CBIRs are localized to presynaptic terminals of cholecystokinin-(CCK) expressing basket cells, a class of GABAergic interneurons...
  27. Food intake and energy metabolism regulated by apo AIV and CCK
    Chunmin C Lo; Fiscal Year: 2013
    Apolipoprotein AIV (apo AIV) and cholecystokinin (CCK) are gut peptides secreted from the small intestine in response to dietary lipids, and each reduces food intake...
  28. CALCIUM AND PANCREATIC STIMULUS-SECRETION COUPLING
    John A Williams; Fiscal Year: 2013
    ..GTPliganded form) of Rab27B andRap1 on zymogen granules and is it increased by secretagogues such as cholecystokinin (CCK) and acetylcholine? Is Rap1important for secretion as has been shown for RabSD and 27B? Does Rap1 ..
  29. Type A CCK Receptor Structure, Function &Regulation
    Laurence J Miller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The cholecystokinin (CCK) receptor is a family A peptide-binding G protein-coupled receptor that has multiple important physiologic functions supporting nutritional homeostasis, including the ..
  30. Brain integration of adiposity and satiety signals in the control of food intake
    Diana Williams; Fiscal Year: 2009
    ..neural circuitry that integrates input from the adiposity hormone leptin and the gut-derived satiety signals cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), and the physiological relevance of the interactions between these ..
  31. Developmental Trajectories of Prefrontal Cortical GABA Neurons and Schizophrenia
    Gil D Hoftman; Fiscal Year: 2013
    ..9-THC), activates cannabinoid 1 receptors (CB1r) that are highly concentrated on the axon terminals of cholecystokinin-expressing basket cells (CB1r/CCK cells) in the primate dorsolateral prefrontal cortex (DLPFC), a region ..
  32. Neural Substrates of Electroacupuncture in Cardiovascular Control
    STEPHANIE CHEE YEE TJEN-A-LOOI; Fiscal Year: 2013
    ..in the rVLM and arcuate during repetitive stimulation in EA's action to lower BP in CI-HTN rats and 4) cholecystokinin neuromodulation of opioid activity in the PVN of animals unresponsive to the actions of EA...
  33. Gastric dysreflexia after spinal cord injury
    Gregory M Holmes; Fiscal Year: 2013
    ..For example, SCI results in 1) diminished postprandial serum expression of cholecystokinin (CCK);2) diminished NTS activation following peripheral sulfated CCK (CCK-8s);3) diminished gastroinhibition ..
  34. Determinants of gestational weight gain in obese pregnant women
    LEANNE MAREE REDMAN; Fiscal Year: 2013
    ..determinants of energy intake including fasting concentrations of leptin, total ghrelin, peptide YY, cholecystokinin and determinants of energy expenditure including urinary epinephrine and norepinephrine, fasting ..
  35. CCK CELL FUNCTION
    Rodger A Liddle; Fiscal Year: 2010
    b>Cholecystokinin (CCK) is produced by discrete enteric endocrine cells (I cells) of the proximal small intestine and secreted into the blood upon ingestion of food. However, the exact nature by which the CCK cell is regulated is unknown...
  36. Type A CCK Receptor Structure Function and Regulation
    Laurence J Miller; Fiscal Year: 2010
    this This proposal to examine the molecular basis of cholecystokinin (CCK) receptor structure, function, and regulation supports the long-term goal of understanding the roles of this gastrointestinal hormone in health and disease...
  37. Brain integration of adiposity and satiety signals in the control of food intake
    Diana L Williams; Fiscal Year: 2011
    ..neural circuitry that Integrates input from the adiposity hormone leptin and the gut-derived satiety signals cholecystokinin (CCK) and glucagon-like peptlde-1 (GLP-1), and the physiological relevance ofthe interactions between these ..
  38. Cannabis and Adolescent Brain Development
    David A Lewis; Fiscal Year: 2012
    ..In primates, the DLPFC is densely innervated by CB1R-immunoreactive (CB1R-IR) axons that arise from the cholecystokinin (CCK)-containing class of GABA basket neurons and that synapse on the soma of pyramidal neurons...
  39. GABA Deficits and Vulnerability to Cannabinoid-Induced Psychosis
    DEEPAK CYRIL D apos SOUZA; Fiscal Year: 2010
    ..CB1 receptors (CB1-Rs) are present on the axon terminals of cholecystokinin (CCK) containing GABA neurons that target pyramidal cells...
  40. Low ph alters intracellular and extracellular communication in the acinar cell
    ANAMIKA MARAGRET REED; Fiscal Year: 2013
    ..and increases oscillation amplitude in isolated acini treated with physiologic concentrations of the cholecystokinin orthologue, cerulein...
  41. Hippocampal inhibitory neuronal circuit organization
    Xiangmin Xu; Fiscal Year: 2013
    ..input to the most numerous inhibitory cell types including parvalbumin-expressing (PV+) basket cells, cholecystokinin- expressing (CCK+) basket cells, axo-axonic cells, and somatostatin-expressing (SOM+) oriens-lacunosum ..
  42. Apolipoprotein AIV regulates CCK secretion and potentiates CCK-induced satiation
    Chunmin C Lo; Fiscal Year: 2013
    ..Apolipoprotein AIV (apo AIV) and cholecystokinin (CCK) are each satiating signals secreted from the small intestine in response to dietary lipids, and the ..
  43. SURGICAL STUDIES ON METABOLISM OF G. I. HORMONES
    James Thompson; Fiscal Year: 1993
    ..We plan to characterize cholecystokinin (CCK), NT, bombesin, and peptide YY (PYY) by HPLC...
  44. The Role of Glutamate in the Control of Food Intake
    Robert C Ritter; Fiscal Year: 2013
    ..NMDAr in the NTS is required for CCK-evoked MAPK signaling and consequent reduction of food intake by cholecystokinin (CCK), the archetypical GI satiation peptide...
  45. NEUROENDOCRINE ETIOLOGY OF DIABETIC GASTROPATHY
    Thomas Nowak; Fiscal Year: 1999
    ..Although neuropeptides such as vasoactive intestinal polypeptide (VIP) and cholecystokinin (CCK) have been shown to influence neuromuscular transmission, the role of endocrine factors in the ..
  46. CALCIUM REGULATION IN ORAL HEALTH
    Rodrigo S Lacruz; Fiscal Year: 2013
    ..Recent work by the PI indicates that Stim1, Orai1 as well as well as the Ca2+ signaling cholecystokinin (Cck) and the Cck inhibitor Rcan1 were identified as being significantly up-regulated in maturation...
  47. Intrinsic Anatomy of the Circadian Rhythm System
    LAWRENCE MORIN; Fiscal Year: 2005
    ..immunoreactive to GAGA, substance P, calbindin, calretinin, vasoactive intestinal polypeptide, vasopressin, cholecystokinin, and gastrin releasing peptide...
  48. CCK MODULATION OF ANXIETY AND THE HPA AXIS
    James Abelson; Fiscal Year: 1999
    b>Cholecystokinin (CCK) is the most abundant peptide neurotransmitter in the brain and its known distribution, interactions, and functions make it of great interest to psychiatry, but it has been little studied in humans...
  49. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 1993
    ..The aim of this proposal is to establish a role for cholecystokinin (CCK) in mediating changes in motility and emptying in response to duodenal stimulation, and investigate its ..
  50. Fibroblast Growth Factor Regulation in the Pancreas
    Sam Holmstrom; Fiscal Year: 2009
    ..The hormonal control of the exocrine pancreas has been well-studied in regards to cholecystokinin (CCK)-induced stimulation of the digestive enzyme secretions...
  51. Studies of a Novel CCK-B/Gastrin Receptor Splice Variant
    MARK HELLMICH; Fiscal Year: 2005
    ..The investigators have identified and isolated the cDNA for a novel splice variant of the human cholecystokinin-B/gastrin receptor (CCK-BR), a member of the G protein-coupled receptor (GPCR) superfamily...
  52. Cholecystokinin is a Physiological Regulator of Intermeal Interval
    Joseph R Reeve; Fiscal Year: 2013
    ..interdisciplinary proposal is to determine the roles and mechanisms of action of large molecular forms of cholecystokinin (CCK) in prolonging the length of the postprandial intermeal interval (IMI) during normal feeding...
  53. FEEDBACK REGULATION OF PANCREATIC SECRETION
    Gary Green; Fiscal Year: 2000
    A cholecystokinin-releasing peptide, termed Luminal CCK-Releasing Factor (LCRF), has been purified from rat intestinal secretions...
  54. Food Rheology and Exercise in Aging Humans
    WAYNE CAMPBELL; Fiscal Year: 2009
    ..appetitive response, differential changes in glucose, insulin and leptin (and possibly neuropeptide Y and cholecystokinin) (each regulators of appetite), and an increase in food intake at the next meal, compared to eating a solid ..
  55. NEURONAL INTERACTIONS IN THE SRI TREATMENT OF PANIC
    Andrew Goddard; Fiscal Year: 2000
    ..system and two other transmitter systems implicated in the pathophysiology of PD, the norepinephrine (NE) and cholecystokinin/peptide (CCK) systems, in relation to the SRI treatment of PD...
  56. PHYSIOLOGY AND PATHOPHYSIOLOGY--SECRETIN, CHOLECYSTOKINI
    William Chey; Fiscal Year: 1999
    The objective of this proposal is to study the mechanisms of secretion and action of secretin (S) and cholecystokinin (CCK)...
  57. NEURAL CONTROL OF THE GALLBLADDER
    Gary Mawe; Fiscal Year: 1992
    ..Although the musculature of the gallbladder responds to hormones, such as cholecystokinin (CCK), there is also a prominent ganglionated neural plexus in the gallbladder wall...
  58. ALTERED ACINAR CELL FUNCTION DURING ACUTE PANCREATITIS
    Robert Powers; Fiscal Year: 1992
    The in vivo administration of the cholecystokinin analogue, caerulein (CER) in excess of the concentration required to induce maximal secretion (hyperstimulation) leads to the rapid formation of acute pancreatitis in mice as defined by ..
  59. CNS CCK IN APPETITIVE AND CONSUMMATORY FOOD MOTIVATION
    ELIOT STELLAR; Fiscal Year: 1991
    The purpose of the proposed studies is to determine the behavioral and biological bases of the effects of cholecystokinin octapeptide (CCK-8) on the rat's responses to food...
  60. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2004
    ..seeks to understand the interactions between pancreatic acinar cells and receptors for bombesin (Bn) and cholecystokinin (CCKA) or gastrin (CCKB)...
  61. CHOLECYSTOKININ EFFECT ON PANCREATIC GROWTH & TUMORS
    Thomas Adrian; Fiscal Year: 1992
    ..that the pancreatic growth in response to feeding raw soya in the rat is accompanied by a rise in plasma cholecystokinin (CCK). Infusion of CCK at a dose which mimics this response causes similar pancreatic growth...
  62. TRANSCRIPTIONAL CONTROL IN NEUROHYPOPHYSIAL NEURONS
    JOSEPH MCCABE; Fiscal Year: 2001
    ..This project will focus upon the regulation of four neuropeptides: vasopressin oxytocin, cholecystokinin, and galanin, in the hypothalamo- neurohypophysial system (NHS) of the CNS...
  63. Mixed Opioid Agonists / Cholecystokinin Antagonists for Treatment of Pain
    Edward Roberts; Fiscal Year: 2011
    ..One prominent neuropeptide that shows enhanced expression in these abnormal pain states is cholecystokinin (CCK)...
  64. NUTRIENT INDUCED GASTRIC PROTECTION--ROLE OF CCK
    David Mercer; Fiscal Year: 2000
    b>Cholecystokinin (CCK) is a gut peptide produced by CCK cells located in the duodenum and proximal jejunum. The major dietary intestinal stimuli for its release are intact proteins and fatty acids...