peptides

Summary

Summary: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

Top Publications

  1. ncbi A statistical model for identifying proteins by tandem mass spectrometry
    Alexey I Nesvizhskii
    Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103, USA
    Anal Chem 75:4646-58. 2003
  2. doi MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
    Jürgen Cox
    Department for Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Nat Biotechnol 26:1367-72. 2008
  3. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
  4. ncbi Prospective identification of tumorigenic prostate cancer stem cells
    Anne T Collins
    Yorkshire Cancer Research Unit, Department of Biology, University of York, York, United Kingdom
    Cancer Res 65:10946-51. 2005
  5. ncbi Identification and expansion of the tumorigenic lung cancer stem cell population
    A Eramo
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Cell Death Differ 15:504-14. 2008
  6. ncbi Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    Brinda Ravikumar
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Nat Genet 36:585-95. 2004
  7. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
  8. ncbi Trinucleotide repeat disorders
    Harry T Orr
    Institute of Human Genetics, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Neurosci 30:575-621. 2007
  9. pmc The immune epitope database 2.0
    Randi Vita
    La Jolla Institute for Allergy and Immunology, Center for Infectious Disease, Allergy and Asthma Research, 9420 Athena Circle, La Jolla, CA 92037, USA
    Nucleic Acids Res 38:D854-62. 2010
  10. pmc CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
    Sergey V Shmelkov
    Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, and Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 118:2111-20. 2008

Detail Information

Publications385 found, 100 shown here

  1. ncbi A statistical model for identifying proteins by tandem mass spectrometry
    Alexey I Nesvizhskii
    Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103, USA
    Anal Chem 75:4646-58. 2003
    A statistical model is presented for computing probabilities that proteins are present in a sample on the basis of peptides assigned to tandem mass (MS/MS) spectra acquired from a proteolytic digest of the sample...
  2. doi MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
    Jürgen Cox
    Department for Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Nat Biotechnol 26:1367-72. 2008
    ..MaxQuant automatically quantifies several hundred thousand peptides per SILAC-proteome experiment and allows statistically robust identification and quantification of >4,000 ..
  3. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
    ....
  4. ncbi Prospective identification of tumorigenic prostate cancer stem cells
    Anne T Collins
    Yorkshire Cancer Research Unit, Department of Biology, University of York, York, United Kingdom
    Cancer Res 65:10946-51. 2005
    ..The identification of a prostate cancer stem cell provides a powerful tool to investigate the tumorigenic process and to develop therapies targeted to the stem cell...
  5. ncbi Identification and expansion of the tumorigenic lung cancer stem cell population
    A Eramo
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Cell Death Differ 15:504-14. 2008
    ..Molecular and functional characterization of such a tumorigenic population may provide valuable information to be exploited in the clinical setting...
  6. ncbi Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    Brinda Ravikumar
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Nat Genet 36:585-95. 2004
    ..Our data provide proof-of-principle for the potential of inducing autophagy to treat Huntington disease...
  7. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
    ..Targeting DNA damage checkpoint response in cancer stem cells may overcome this radioresistance and provide a therapeutic model for malignant brain cancers...
  8. ncbi Trinucleotide repeat disorders
    Harry T Orr
    Institute of Human Genetics, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Neurosci 30:575-621. 2007
    ..It is exciting that within a span of 15 years, pathogenesis studies of this class of disorders are beginning to reveal pathways that are potential therapeutic targets...
  9. pmc The immune epitope database 2.0
    Randi Vita
    La Jolla Institute for Allergy and Immunology, Center for Infectious Disease, Allergy and Asthma Research, 9420 Athena Circle, La Jolla, CA 92037, USA
    Nucleic Acids Res 38:D854-62. 2010
    ..The database structure, as well as its querying, browsing and reporting interfaces, was completely redesigned for the IEDB 2.0 release, which became publicly available in early 2009...
  10. pmc CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
    Sergey V Shmelkov
    Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, and Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 118:2111-20. 2008
    ....
  11. ncbi Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search
    Andrew Keller
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Anal Chem 74:5383-92. 2002
    ..peptide assignments to spectra are correct based upon database search scores and the number of tryptic termini of peptides. Using SEQUEST search results for spectra generated from a sample of known protein components, we demonstrate ..
  12. ncbi A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations
    Yong Duan
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    J Comput Chem 24:1999-2012. 2003
    ..main-chain torsion parameters were obtained by fitting to the energy profiles of Ace-Ala-Nme and Ace-Gly-Nme di-peptides calculated using MP2/cc-pVTZ//HF/6-31G** quantum mechanical methods...
  13. ncbi The Paragon Algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass spectra
    Ignat V Shilov
    Applied Biosystems MDS Sciex, Foster City, CA 94404, USA
    Mol Cell Proteomics 6:1638-55. 2007
    The Paragon Algorithm, a novel database search engine for the identification of peptides from tandem mass spectrometry data, is presented...
  14. ncbi Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips
    Juri Rappsilber
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    Nat Protoc 2:1896-906. 2007
    Mass spectrometry (MS)-based proteomics measures peptides derived from proteins by proteolytic cleavage...
  15. ncbi Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
    Shao En Ong
    Protein Interaction Laboratory, University of Southern Denmark, Odense, Denmark
    Mol Cell Proteomics 1:376-86. 2002
    ..SILAC is a simple, inexpensive, and accurate procedure that can be used as a quantitative proteomic approach in any cell culture system...
  16. pmc Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
    Giulia Bertolini
    Molecular Cytogenetics Unit, Department of Experimental Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 106:16281-6. 2009
    ..The molecular features of these cells may provide the rationale for more specific therapeutic targeting and the definition of predictive factors in clinical management of this lethal disease...
  17. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
    ..The identification of a BTSC provides a powerful tool to investigate the tumorigenic process in the central nervous system and to develop therapies targeted to the BTSC...
  18. pmc Alzheimer's disease beta-amyloid peptides are released in association with exosomes
    Lawrence Rajendran
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 103:11172-7. 2006
    ..of Alzheimer's disease (AD) is a topic of debate, the consensus is that the accumulation of beta-amyloid (Abeta) peptides in the senile plaques is one of the hallmarks of the progression of the disease...
  19. doi Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    Matilde Todaro
    Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, 90127 Palermo, Italy
    Cell Stem Cell 1:389-402. 2007
    ..Our data suggest that colon tumor growth is dictated by stem-like cells that are treatment resistant due to the autocrine production of IL-4...
  20. ncbi Identification of human brain tumour initiating cells
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada
    Nature 432:396-401. 2004
    ....
  21. doi Huntington's disease: from molecular pathogenesis to clinical treatment
    Christopher A Ross
    Departments of Psychiatry, Neurology, Pharmacology, and Neuroscience, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet Neurol 10:83-98. 2011
    ..Thus, Huntington's disease is also emerging as a model for strategies to develop therapeutic interventions, not only to slow progression of manifest disease but also to delay, or ideally prevent, its onset...
  22. pmc Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    Michael Elashoff
    Larry L Hillblom Islet Research Center at David Geffen School of Medicine and Department of Biomathematics, University of California, Los Angeles, California 90095 7073, USA
    Gastroenterology 141:150-6. 2011
    ..There are also concerns that dipeptidyl peptidase-4 inhibitors could cause cancer, given their effects on immune function...
  23. ncbi Antimicrobial peptides of multicellular organisms
    Michael Zasloff
    Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104 6059, USA
    Nature 415:389-95. 2002
    ..How is this accomplished? Both animals and plants possess potent, broad-spectrum antimicrobial peptides, which they use to fend off a wide range of microbes, including bacteria, fungi, viruses and protozoa...
  24. ncbi Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
    Ana Maria Fernandez-Escamilla
    Nat Biotechnol 22:1302-6. 2004
    ..Our algorithm accurately predicts the aggregation of a data set of 179 peptides compiled from the literature as well as of a new set of 71 peptides derived from human disease-related proteins, ..
  25. ncbi Identification and characterization of tumorigenic liver cancer stem/progenitor cells
    Stephanie Ma
    Department of Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Gastroenterology 132:2542-56. 2007
    ..The aim of this study is to identify, isolate, and characterize the CSC population that drives and maintains hepatocellular carcinoma (HCC) growth and metastasis...
  26. ncbi Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
    John Rush
    Cell Signaling Technology Inc, 166B Cummings Center, Beverly, Massachusetts 01915, USA
    Nat Biotechnol 23:94-101. 2005
    ..In general, global phosphoproteomic approaches reveal small numbers of peptides containing phosphotyrosine...
  27. ncbi Interpretation of shotgun proteomic data: the protein inference problem
    Alexey I Nesvizhskii
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Mol Cell Proteomics 4:1419-40. 2005
    The shotgun proteomic strategy based on digesting proteins into peptides and sequencing them using tandem mass spectrometry and automated database searching has become the method of choice for identifying proteins in most large scale ..
  28. ncbi ProPred: prediction of HLA-DR binding sites
    H Singh
    Bioinformatics Centre, Institute of Microbial Technology, Sector 39A, Chandigarh-160036, India
    Bioinformatics 17:1236-7. 2001
    ..AVAILABILITY: The server is available at http://www.imtech.res.in/raghava/propred/ CONTACT: raghava@imtech.res.in SUPPLEMENTARY INFORMATION: http://www.imtech.res.in/raghava/propred/page3.html..
  29. pmc Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells
    Yu Chih Chen
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 3:e2637. 2008
    ..Future research is warranted regarding the up-regulated expression of Oct-4 in LC-CD133(+) and malignant lung cancer...
  30. doi DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes
    Thomas Blevins
    Texas Diabetes and Endocrinology, 6500 North Mopac Expressway, Building 3, Suite 200, Austin, Texas 78731, USA
    J Clin Endocrinol Metab 96:1301-10. 2011
    ..We wanted to understand the effects of once-weekly vs. twice-daily glucagon-like peptide-1 receptor agonism for treatment of patients with type 2 diabetes...
  31. pmc AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
    Oscar Conchillo-Solé
    Institut de Biotecnologia i de Biomedicina IBB, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    BMC Bioinformatics 8:65. 2007
    ....
  32. pmc Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono)
    Vivian A Fonseca
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Diabetes Care 35:1225-31. 2012
    ..To assess efficacy and safety of lixisenatide monotherapy in type 2 diabetes...
  33. pmc Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
    Michelle Gray
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 28:6182-95. 2008
    ..In summary, the BACHD model constitutes a novel and robust in vivo paradigm for the investigation of HD pathogenesis and treatment...
  34. ncbi Identification and expansion of human colon-cancer-initiating cells
    Lucia Ricci-Vitiani
    Department of Hematology and Oncology, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Nature 445:111-5. 2007
    ..We conclude that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies...
  35. pmc PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides
    Pierre Thévenet
    INSERM, U973, MTI, Paris, France
    Nucleic Acids Res 40:W288-93. 2012
    In the context of the renewed interest of peptides as therapeutics, it is important to have an on-line resource for 3D structure prediction of peptides with well-defined structures in aqueous solution...
  36. ncbi CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    S Ma
    Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Oncogene 27:1749-58. 2008
    ..Targeting of this specific survival signaling pathway in CD133+ HCC CSCs may provide a novel therapeutic model for the disease...
  37. doi miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    Stephanie Ma
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Cell Stem Cell 7:694-707. 2010
    ..Silencing TP53INP1 in CD133⁻ cells enhanced both self renewal and tumorigenicity in vivo. Collectively, miR-130b regulates CD133(+) liver TICs, in part, via silencing TP53INP1...
  38. pmc Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)
    Y Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Diabetes Obes Metab 14:910-7. 2012
    ..To assess the efficacy and safety of once-daily lixisenatide versus placebo in Asian patients with type 2 diabetes insufficiently controlled on basal insulin ± sulfonylurea...
  39. ncbi How TCRs bind MHCs, peptides, and coreceptors
    Markus G Rudolph
    Department of Molecular Structural Biology, University of Gottingen, 37077 Gottingen, Germany
    Annu Rev Immunol 24:419-66. 2006
    ..Notwithstanding, the impressive array of self, foreign (microbial), and autoimmune TCR complexes have uncovered the diverse ways in which antigens can be specifically recognized by TCRs...
  40. doi Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial
    Michaela Diamant
    Diabetes Centre, VU University Medical Centre, Amsterdam, Netherlands
    Lancet 375:2234-43. 2010
    ..We aimed to test the hypothesis that improvement in haemoglobin A(1c) (HbA(1c)) achieved with once weekly exenatide was superior to that achieved with insulin glargine titrated to glucose targets...
  41. doi Use of twice-daily exenatide in Basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial
    John B Buse
    University of North Carolina School of Medicine, Chapel Hill, 27599, USA
    Ann Intern Med 154:103-12. 2011
    ..Insulin replacement in diabetes often requires prandial intervention to reach hemoglobin A₁(c) (HbA₁(c)) targets...
  42. ncbi Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    G Xu
    Elliott P Joslin Research Laboratories, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Diabetes 48:2270-6. 1999
    ..Thus, GLP-I and analogs thereof hold promise as a novel therapy to stimulate beta-cell growth and differentiation when administered to diabetic individuals with reduced beta-cell mass...
  43. pmc Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    Masayuki Arakawa
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Diabetes 59:1030-7. 2010
    ..The aim of this study was to investigate the effects of GLP-1 on accumulation of monocytes/macrophages on the vascular wall, one of the earliest steps in atherosclerogenesis...
  44. ncbi Quantitative mass spectrometry in proteomics: a critical review
    Marcus Bantscheff
    Cellzome AG, Meyerhofstrasse 1, 69254, Heidelberg, Germany
    Anal Bioanal Chem 389:1017-31. 2007
    ..These mass tags can be introduced into proteins or peptides (i) metabolically, (ii) by chemical means, (iii) enzymatically, or (iv) provided by spiked synthetic peptide ..
  45. pmc LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 23:833-43. 2004
    ..Between them, these kinases may mediate the physiological effects of LKB1, including its tumour suppressor function...
  46. pmc Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    Emina H Huang
    Department of Surgery, University of Florida, Gainesville, Florida, USA
    Cancer Res 69:3382-9. 2009
    ..These findings also support our original hypothesis, derived previously from mathematical modeling of crypt dynamics, that progressive colonic SC overpopulation occurs during colon tumorigenesis and drives CRC development...
  47. pmc Cancerous stem cells can arise from pediatric brain tumors
    Houman D Hemmati
    Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 100:15178-83. 2003
    ..This finding may have important implications for treatment by means of specific targeting of stem-like cells within brain tumors...
  48. ncbi Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    S Davis
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1161-9. 1996
    ..However, its expression in close proximity with developing blood vessels implicates Angiopoietin-1 in endothelial developmental processes...
  49. doi Plant peptides govern terminal differentiation of bacteria in symbiosis
    Willem Van de Velde
    Institut des Sciences du Vegetal, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette Cedex, France
    Science 327:1122-6. 2010
    ..We demonstrated that these factors are nodule-specific cysteine-rich (NCR) peptides that are targeted to the bacteria and enter the bacterial membrane and cytosol...
  50. pmc Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor
    M Zasloff
    Proc Natl Acad Sci U S A 84:5449-53. 1987
    A family of peptides with broad-spectrum antimicrobial activity has been isolated from the skin of the African clawed frog Xenopus laevis...
  51. doi Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis
    Satoru Mochida
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
    Science 330:1670-3. 2010
    ..This converts Ensa into a potent and specific inhibitor of PP2A-B55δ. This pathway represents a previously unknown element in the control of mitosis...
  52. pmc PeptideAtlas: a resource for target selection for emerging targeted proteomics workflows
    Eric W Deutsch
    Institute for Systems Biology, 1441 N 34th Street, Seattle, Washington 98103, USA
    EMBO Rep 9:429-34. 2008
    ..The PeptideAtlas Project comprises a growing, publicly accessible database of peptides identified in many tandem mass spectrometry proteomics studies and software tools that allow the building of ..
  53. pmc The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
    James F Morley
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 99:10417-22. 2002
    ....
  54. pmc Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    Manish J Butte
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 27:111-22. 2007
    ..Our findings point to a substantial bidirectional inhibitory interaction between B7-1 and PD-L1 and add an additional dimension to immunoregulatory functions of the B7:CD28 family...
  55. pmc Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
    Janghoo Lim
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 452:713-8. 2008
    ..This model provides mechanistic insight into the molecular pathogenesis of SCA1 as well as other polyglutamine diseases...
  56. ncbi Assigning significance to peptides identified by tandem mass spectrometry using decoy databases
    LUKAS KALL
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 7:29-34. 2008
    Automated methods for assigning peptides to observed tandem mass spectra typically return a list of peptide-spectrum matches, ranked according to an arbitrary score...
  57. ncbi Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector
    Andrea L Szymczak
    Nat Biotechnol 22:589-94. 2004
    ..Here we used Picornavirus 'self-cleaving' 2A peptides, or 2A-like sequences from other viruses, to generate multicistronic retroviral vectors with efficient ..
  58. ncbi Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents
    Philip L Ross
    Applied Biosystems, Framingham, MA 01701, USA
    Mol Cell Proteomics 3:1154-69. 2004
    ..At the core of this methodology is a multiplexed set of isobaric reagents that yield amine-derivatized peptides. The derivatized peptides are indistinguishable in MS, but exhibit intense low-mass MS/MS signature ions that ..
  59. ncbi Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
    J S Steffan
    Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, California 92697, USA
    Nature 413:739-43. 2001
    ..These findings raise the possibility that therapy with HDAC inhibitors may slow or prevent the progressive neurodegeneration seen in Huntington's disease and other polyglutamine-repeat diseases, even after the onset of symptoms...
  60. pmc Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics
    Frederic Heitz
    Centre de Recherches de Biochimie Macromoleculaire, UMR 5237, CNRS, UM 1, UM 2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, Montpellier, France
    Br J Pharmacol 157:195-206. 2009
    ..technologies have been designed to improve cellular uptake of therapeutic molecules, including cell-penetrating peptides (CPPs). CPPs were first discovered based on the potency of several proteins to enter cells...
  61. doi Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha
    A Soeda
    Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Oncogene 28:3949-59. 2009
    ..This study illustrates the importance of the tumor microenvironment in determining cellular behavior...
  62. pmc Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    Nitika Arora Gupta
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hepatology 51:1584-92. 2010
    ..Small interfering RNA against GLP-1R abolished the effects on PDK-1 and PKC-zeta. Treatment with exendin-4 quantitatively reduced triglyceride stores compared with control-treated cells...
  63. doi Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial
    Richard M Bergenstal
    International Diabetes Center at Park Nicollet, Minneapolis, MN 55416, USA
    Lancet 376:431-9. 2010
    ....
  64. ncbi Converting a peptide into a drug: strategies to improve stability and bioavailability
    Celine Adessi
    Serono Pharmaceutical Research Institute, Geneva, Switzerland
    Curr Med Chem 9:963-78. 2002
    ..implicated in vital biological functions of our organism has increased interest in therapeutic use of short peptides. However, the development of peptides as clinically useful drugs is greatly limited by their poor metabolic ..
  65. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
    ....
  66. pmc Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
    Andrew C Elden
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 466:1069-75. 2010
    ..Furthermore, these findings indicate that the TDP-43-ATXN2 interaction may be a promising target for therapeutic intervention in ALS and other TDP-43 proteinopathies...
  67. doi CD133 expression defines a tumor initiating cell population in primary human ovarian cancer
    Michael D Curley
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Stem Cells 27:2875-83. 2009
    ..Our data indicate that CD133 expression defines a NOD/SCID tumor initiating subpopulation of cells in human ovarian cancer that may be an important target for new chemotherapeutic strategies aimed at eliminating ovarian cancer...
  68. ncbi Glutamine repeats and neurodegeneration
    H Y Zoghbi
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Neurosci 23:217-47. 2000
    ..The review concludes with a model for pathogenesis that illuminates the unifying features of these polyglutamine disorders. This model may prove relevant to other neurodegenerative disorders as well...
  69. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
    ..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
  70. pmc Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
    Madhav D Sharma
    Department of Pediatrics, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Invest 117:2570-82. 2007
    ..We hypothesize that IDO+ pDCs create a profoundly suppressive microenvironment within tumor-draining LNs via constitutive activation of Tregs...
  71. pmc Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer
    A Lugli
    Institute of Pathology, University of Basel, Basel, Switzerland
    Br J Cancer 103:382-90. 2010
    ..The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer...
  72. ncbi The glucagon-like peptides
    T J Kieffer
    Department of Medicine, University of Alberta, Edmonton, Canada
    Endocr Rev 20:876-913. 1999
  73. pmc Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
    Marta Martinez-Vicente
    Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York, USA
    Nat Neurosci 13:567-76. 2010
    ..We propose that inefficient engulfment of cytosolic components by autophagosomes is responsible for their slower turnover, functional decay and accumulation inside HD cells...
  74. ncbi Substrate-specific activation of sirtuins by resveratrol
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:17038-45. 2005
    ..de Lys, a non-physiological fluorescent moiety, but has no effect on binding and deacetylation of acetylated peptides lacking the fluorophore...
  75. ncbi PEGylation, successful approach to drug delivery
    Francesco M Veronese
    Department of Pharmaceutical Sciences, Padua University, Italy
    Drug Discov Today 10:1451-8. 2005
    ..Thanks to these favorable properties, PEGylation now plays an important role in drug delivery, enhancing the potentials of peptides and proteins as therapeutic agents.
  76. pmc RNA toxicity is a component of ataxin-3 degeneration in Drosophila
    Ling Bo Li
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
    Nature 453:1107-11. 2008
    ..These studies reveal a role for the RNA in polyQ toxicity, highlighting common components in RNA-based and polyQ-protein-based trinucleotide repeat expansion diseases...
  77. doi Peptides and aptamers targeting HSP70: a novel approach for anticancer chemotherapy
    Anne Laure Rérole
    Inserm UMR 866, Faculty of Medicine and Pharmacy, Dijon, France
    Cancer Res 71:484-95. 2011
    ..Altogether, these data indicate that peptide aptamers or peptides that target HSP70 may be considered as novel lead compounds for cancer therapy.
  78. pmc Non-ATG-initiated translation directed by microsatellite expansions
    Tao Zu
    Department of Genetics Cell Biology and Development, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 108:260-5. 2011
    ..These results have implications for understanding fundamental mechanisms of gene expression. Moreover, these toxic, unexpected, homopolymeric proteins now should be considered in pathogenic models of microsatellite disorders...
  79. doi Conserved regulation of cardiac calcium uptake by peptides encoded in small open reading frames
    Emile G Magny
    School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 9QG, UK
    Science 341:1116-20. 2013
    Small open reading frames (smORFs) are short DNA sequences that are able to encode small peptides of less than 100 amino acids. Study of these elements has been neglected despite thousands existing in our genomes...
  80. ncbi Diseases of unstable repeat expansion: mechanisms and common principles
    Jennifer R Gatchel
    Department of Neuroscience, Medical Scientist Training Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Genet 6:743-55. 2005
    ..In all these diseases, the context of the expanded repeat and the abundance, subcellular localization and interactions of the proteins and RNAs that are affected have key roles in disease-specific phenotypes...
  81. ncbi Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
    Chad Vickers
    Department of Metabolic Disease, Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 277:14838-43. 2002
    ..ACE2 was screened for hydrolytic activity against a panel of 126 biological peptides, using liquid chromatography-mass spectrometry detection...
  82. pmc Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool
    Maya A Olshina
    Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia
    J Biol Chem 285:21807-16. 2010
    ....
  83. pmc PepX: a structural database of non-redundant protein-peptide complexes
    Peter Vanhee
    VIB Switch Laboratory, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium
    Nucleic Acids Res 38:D545-51. 2010
    ..Moreover, we provide an additional source of data for peptide design by annotating peptides with naturally occurring backbone variations using fragment clusters from the BriX database.
  84. pmc Integrin alpha 6 regulates glioblastoma stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Stem Cell 6:421-32. 2010
    ..Our results provide evidence that GSCs express high levels of integrin alpha6, which can serve not only as an enrichment marker but also as a promising antiglioblastoma therapy...
  85. pmc The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations
    Anna Dubrovska
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:268-73. 2009
    ....
  86. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
    ..These findings have implications for the design of T cell-based cancer immunotherapy...
  87. doi Identification of cross-linked peptides from complex samples
    Bing Yang
    College of Biological Sciences, China Agricultural University, Beijing, China
    Nat Methods 9:904-6. 2012
    ..We show that it is a robust tool for protein-structure and protein-protein-interaction studies...
  88. ncbi Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS
    Andrew Thompson
    Proteome Sciences, Coveham House, Downside Bridge Road, Cobham, Surrey, KT11 3EP, UK
    Anal Chem 75:1895-904. 2003
    ..using isotopomer labels, referred to as "tandem mass tags" (TMTs), for the accurate quantification of peptides and proteins is described...
  89. pmc A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress
    Onn Brandman
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 151:1042-54. 2012
    ..Our work reveals the range of stresses Hsf1 monitors and elucidates a conserved cotranslational protein quality control mechanism...
  90. doi iAMP-2L: a two-level multi-label classifier for identifying antimicrobial peptides and their functional types
    Xuan Xiao
    Computer Department, Jing De Zhen Ceramic Institute, Jing De Zhen 333403, China
    Anal Biochem 436:168-77. 2013
    Antimicrobial peptides (AMPs), also called host defense peptides, are an evolutionarily conserved component of the innate immune response and are found among all classes of life...
  91. ncbi A receptor that mediates the post-mating switch in Drosophila reproductive behaviour
    Nilay Yapici
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 451:33-7. 2008
    ..SPR is highly conserved across insects, opening up the prospect of new strategies to control the reproductive and host-seeking behaviours of agricultural pests and human disease vectors...
  92. ncbi Self-assembly and mineralization of peptide-amphiphile nanofibers
    J D Hartgerink
    Department of Materials Science and Engineering, Medical School, Northwestern University, 2225 North Campus Drive, Evanston, IL 60208, USA
    Science 294:1684-8. 2001
    ..This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone...
  93. ncbi Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
    Rong Wang
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840, USA
    Nat Med 13:1510-4. 2007
    ..Here we describe a class of secreted staphylococcal peptides that have a remarkable ability to recruit, activate and subsequently lyse human neutrophils, thus eliminating the ..
  94. pmc Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry
    John E P Syka
    Engineering Physics Program, University of Virginia, Charlottesville, VA 22901, USA
    Proc Natl Acad Sci U S A 101:9528-33. 2004
    ..Singly charged anthracene anions transfer an electron to multiply protonated peptides in a radio frequency quadrupole linear ion trap (QLT) and induce fragmentation of the peptide backbone along ..
  95. pmc Prediction of antimicrobial peptides based on sequence alignment and feature selection methods
    Ping Wang
    Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
    PLoS ONE 6:e18476. 2011
    Antimicrobial peptides (AMPs) represent a class of natural peptides that form a part of the innate immune system, and this kind of 'nature's antibiotics' is quite promising for solving the problem of increasing antibiotic resistance...
  96. ncbi Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
    Jesper V Olsen
    Center for Experimental Bioinformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense, Denmark
    Cell 127:635-48. 2006
    ..The dynamic phosphoproteome provides a missing link in a global, integrative view of cellular regulation...
  97. doi The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A
    Aicha Gharbi-Ayachi
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Science 330:1673-7. 2010
    ..Although both proteins can inhibit PP2A, endogenous Arpp19, but not α-Endosulfine, is responsible for PP2A inhibition at mitotic entry in Xenopus egg extracts...
  98. pmc A helix propensity scale based on experimental studies of peptides and proteins
    C N Pace
    Department of Medical Biochemistry and Genetics, Texas A and M University, College Station, Texas 77843 1114, USA
    Biophys J 75:422-7. 1998
    ..The scale is based on measurements of helix propensity in 11 systems, including both proteins and peptides. Alanine has the highest helix propensity, and, excluding proline, glycine has the lowest, approximately 1 kcal/..
  99. pmc PDZ domain binding selectivity is optimized across the mouse proteome
    Michael A Stiffler
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Science 317:364-9. 2007
    ..polarization to characterize the binding selectivity of 157 mouse PDZ domains with respect to 217 genome-encoded peptides. We then trained a multidomain selectivity model to predict PDZ domain-peptide interactions across the mouse ..
  100. doi Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis
    T Kondo
    Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology NIBB, National Institutes of Natural Sciences, 5 1 Myodaiji Higashiyama, Okazaki 444 8787, Japan
    Science 329:336-9. 2010
    ..Recent findings suggest, however, that some sORFs encode small bioactive peptides. Here, we show that peptides of 11 to 32 amino acids encoded by the polished rice (pri) sORF gene control ..
  101. pmc Production of lantipeptides in Escherichia coli
    Yanxiang Shi
    Howard Hughes Medical Institute, Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Am Chem Soc 133:2338-41. 2011
    Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing thioether cross-links...

Research Grants84

  1. DnaK Protein Inhibitor Antimicrobials
    Michael Sturgess; Fiscal Year: 2003
    The activity spectrum and mode of action of native antibacterial peptides represent some of the most exciting subjects of the Millennium, mostly because of the rapid increase of bacteria that become resistant to conventional antibiotics, ..
  2. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  3. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..Proteolytic processing of Chga gives rise to biologically active peptides such as the dysglycemic hormone pancreastatin, vasodilator vasostatin, and the catecholamine release inhibitory ..
  4. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..While many food intake inhibitory peptides are released in the gastrointestinal tract, only one peptide, ghrelin, elicits feed-forward characteristics...
  5. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..In this proposal Aim 1 seeks to examine whether chitosan and HKP can be modified with transdermal peptides while maintaining their siRNA carrying capability...
  6. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..proposal seeks support for 'proof of principle" experiments that chelators, conjugated to ferritin binding peptides, will increase iron removal from cultured cells...
  7. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..However, since CD4 and CD8 12 T cells recognize these peptides bound to MHC molecules in an MHC-restricted fashion, immunotherapy with 12 T cells needs to be individualized for ..
  8. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..we have shown that antennapedia (AP), a Drosophila transcription factor that facilitates uptake of peptides and oligonucleotides into mammalian cells, when complexed with PLGA nanoparticles (AP-PLGA) adheres effectively ..
  9. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..On the other hand, DQ8 can present native and de-amidated peptides thus generating a robust immune response to an antigen...
  10. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..extracellular senile plaques in the brain primarily composed of 40-42 amino acid length amyloid beta (A(1-40, 42) peptides. Strategies targeting the clearance of A( plaques or neutralization of the precursor soluble or oligomeric forms ..
  11. Phage Display for Improved Peptide-based Tumor Targeting and Imaging Agents
    Susan L Deutscher; Fiscal Year: 2013
    ..Radiolabeled antibodies and peptides are currently being explored as diagnostic cancer imaging agents...
  12. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..The discovery that small BVR-based peptides can effectively intervene in the MAPK pathway at several key junctions is a highly relevant finding toward the ..
  13. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..Most of the critical peptides involved in the regulation of energy homeostasis have been colocalized with the inhibitory transmitter GABA in ..
  14. Tissue-specific delivery of probes by control of membrane trafficking of endoprot
    Blake Peterson; Fiscal Year: 2010
    ..N-alkyl- 3[unreadable]-cholesterylamines to dramatically enhance the volume of distribution (Vd) of linked peptides, drugs, and probes in vivo...
  15. TARGETING THE MARCKS-FAMILY PROTEINS TO INHIBIT NEUTROPHIL MIGRATION
    Mary K Sheats; Fiscal Year: 2013
    ..In these experiments, MARCKS or MARCKSL1 inhibition will be accomplished using: cell permeant peptides identical to the 24 amino acids of the N-terminus of each protein, transgenic expression of a truncated ..
  16. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..terminate pancreatic inflammation by examining the role of metalloendopeptidases that degrade proinflammatory peptides on the cell surface and in endosomes...
  17. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..we propose to optimize the in vitro potency and in vivo safety of C5A by creating a second generation of peptides using the parental C5A peptide as the archetype...
  18. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..One component of innate immunity is the production of antibiotic peptides such as - defensins...
  19. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013
    ..By glyco-engineering technology, capsular polysaccharides are conjugated to known protective peptides without denaturing the protein carrier, thus conserving B cell epitopes...
  20. Novel Reagents and Methods for Rapid and High Throughput Detection of Aflatoxin C
    ALAN AI PING WEI; Fiscal Year: 2013
    ..S. patents on peptide and DNA beacons. Many AF-mimetic peptides have been discovered and reported in the literature that specifically competes with AF in antibody binding...
  21. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..These professional antigen presenting cells (APC) also endocytose HIV-1 and present viral peptides to responding T cells in association with HLA class I and class II proteins...
  22. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..Recent data reveals that GLP-1 and its homologue improve insulin resistance. These peptides have pleotropic effects including stimulating growth of b cells of the pancreas and action on adipocytes...
  23. Regulation of Islet Beta-Cell Function via Islet-Derived VGF Peptides
    SAMUEL BRANDON STEPHENS; Fiscal Year: 2013
    ..Pro-VGF is differentially cleaved by the hormone processing enzymes PC1/3 and PC2;VGF peptides are stored in dense core granules and secreted via the regulated secretory pathway...
  24. Role of beta-endorphin in cancer therapy induced fatigue
    David E Fisher; Fiscal Year: 2013
    ..In turn, POMC is cleaved into several peptides, one of which, Melanocyte Stimulating Hormone, activates pigmentation...
  25. Robust Peptide-Based Diagnostics of Botulinum Toxins
    John E Mueller; Fiscal Year: 2012
    ..Long term, we envisage the incorporation of short, high-affinity peptides into a highly-sensitive, label-free, multiplexed electrical detection platform, premised on silicon nanowire ..
  26. Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome Risk
    PEI AN SHIH; Fiscal Year: 2013
    ..associations are difficult to identify due to the intermixed neuronal and hormonal functions of PP-fold peptides and their ability to bind both receptors...
  27. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2011
    ..Wenyuan Shi at University of California in Los Angeles who has developed specifically targeted anti-microbial peptides (STAMPs)...
  28. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..The results would open a new field of study and point the way to new avenues of investigation for pharmacological agents to treat diarrhea and/or constipation. ..
  29. Neuropeptide modulation of biogenic amine function and aggression in a crustacean
    Maria A Sosa; Fiscal Year: 2013
    ..OA) have on aggressive behavior of dominant and submissive freshwater prawns are modulated by neuroactive peptides. Adult male prawns develop through three morphotypes, corresponding with the animal's status in a dominance ..
  30. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..in important mediators of pulmonary transition at birth such as nitric oxide, beta adrenergic agents, natriuretic peptides and prostaglandins secondary to antenatal glucocorticoid use...
  31. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..elastase derived elastin fragments as foreign antigen and that individuals with stronger response to elastin peptides, have more advanced emphysema...
  32. Beta Cell Adaptation to Stress in Baboon Pancreas After Partial Pancreatectomy
    FRANCO BATTISTA FOLLI; Fiscal Year: 2010
    ..Recent evidence suggests that [unreadable]-cell toxicity of amyloidogenic peptides results, not in the deposits visible by light microscopy, but rather from intracellular fibril aggregates and ..
  33. Mechanisms of Diabetic Hyperphagia and Insulin Resistance
    Michael W Schwartz; Fiscal Year: 2012
    ..ARC neuronal subsets activated in uDM are those that express orexigenic (or 'food intake-stimulatory') peptides such as neuropeptide Y (NPY) and agouti-related peptide (AgRP), whereas adjacent anorexigenic, melanocortin-..
  34. Comparative Effectiveness of Medical Therapy vs. Bariatric Surgery for Obese T2DM
    DAVID BRADLEY contact LAUTZ; Fiscal Year: 2010
    ..Differences may be due to mild malabsorption or alterations in gut peptides that regulate appetite and facilitate sustained weight loss, and/or to changes in incretins that may improve [..
  35. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MARITA MIETTINEN; Fiscal Year: 2010
    ..FPR binds bacterial peptides with high affinity and results in neutrophil chemotaxis and bacterial killing through activation of the NADPH ..
  36. Neuropilin and semaphorin, anti-angiogenesis activities and mechanisms
    Michael Klagsbrun; Fiscal Year: 2009
    ..mechanisms by which semaphorins inhibit tumor angiogenesis;2) To develop NRP2 B domain mutants and VEGF exon 7/8 peptides as VEGF antagonists and inhibitors of angiogenesis;3) To discover novel functions of NRP2 and its ligand, SEMA3F...
  37. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..The work described in this proposal focuses on elucidating mechanisms to support the use of caveolin proteins as novel therapeutic targets for heart failure patients and is of relevance to the VA patient care mission. ..
  38. CTL response to AAV Vector
    Richard J Samulski; Fiscal Year: 2013
    ..Many viruses (For example herpes, EB) evade host immune response by synthesizing small peptides called viral proteins interfering with antigen presentation (VIPR), we propose that integration of VIPR into AAV ..
  39. Validation of a Novel NF-kB Inhibitor in Inflammatory Bowel Disease
    Anthony Blikslager; Fiscal Year: 2013
    ..have been at the forefront of NF??B research and hold intellectual property pertaining to novel NF??B inhibitor peptides including TLX1423...
  40. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2013
    ..Wenyuan Shi at University of California in Los Angeles who has developed specifically targeted anti-microbial peptides (STAMPs)...
  41. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..Human airways are lined by a thin layer of liquid, airway surface liquid (ASL) that contains many antibacterial peptides which play an important role in innate immunity. The antibacterial activity of ASL is NaCI (salt) sensitive...
  42. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..At lower dosages, the peptides will be assessed for inhibition of pro-inflammatory factor expressions in RA-FLS, and inhibition of several ..
  43. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Veena Taneja; Fiscal Year: 2013
    ..On the other hand, DQ8 can present native and de-amidated peptides derived from synovial proteins generating a robust autoimmune response...
  44. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    ..Several peptides and two isomeric small molecules that we identified antagonize EphA4-ephrin binding and are much more selective ..
  45. Localization and characterization of the Clostridium difficile biofilm
    Adam Driks; Fiscal Year: 2013
    ..only facilitate attachment to the mucosa but also exclude critical host-defense molecules such as antimicrobial peptides and antibodies, and avoid recognition by the immune system. A C...
  46. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..important neuroendocrine component of the sympathetic nervous system that release a cocktail of catecholamines, peptides, and others transmitters to ensure coordinated physiological responses, for example during the "fight-or-flight" ..
  47. Proteomic signatures of an early life asthma-protective exposure
    Serrine S Lau; Fiscal Year: 2010
    ..MS is the method of choice for sequencing peptides and proteins with limited amounts of available sample, targeting low abundance proteins and detecting low rates ..
  48. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David R Brown; Fiscal Year: 2010
    ..In Specific Aim 2, we will compare the morphological interrelationships between opioid receptors and opioid peptides in epithelial cells, neurons and leukocytes of Peyer's patch and absorptive mucosae by immunocytochemical ..
  49. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    ..of several omptin proteases, including inhibition of the degradation of alpha-2- antiplasmin and antimicrobial peptides, as well as inhibition of invasion of cultured cells by Y. pestis...
  50. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..Thus, there is a profound need for designing delivery vehicles for vaccine peptides. Current nanocarriers mainly consist of liposomes and polymers, which are larger in size (>100nm in diameter) ..
  51. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..unique molecular markers that provide a specific molecular "zip" code defined by phage display screen of binding peptides. These peptides can be used for cell specific diagnostic imaging using molecular nanoplatforms with phage-..
  52. Molecular Determinants of DNA Sliding and Hopping by a DNA Repair Glycosylase
    MENG MENG ROWLAND; Fiscal Year: 2013
    ..Fusion proteins between hUNG and short, positively charged peptides will be constructed using expressed protein ligation technology (EPL) and/or chemical ligation...
  53. Multiplexed DNA Origami-Based Biomarker Detection Assay for Early Dx of Arthritis
    John E Mueller; Fiscal Year: 2013
    ..Phase I, we will evaluate the feasibility of performing DNA origami selections against the CTX-II, CTX-I and C2C peptides to identify DNA sequences that we will develop as probes in an assay to specifically diagnose AR...
  54. RYGB Improves Metabolism by Interrupting the Gastric Adipose Tissue Axis
    Naji N Abumrad; Fiscal Year: 2013
    ..ii) Ex vivo studies will assess mechanistic aspects of stomach-derived peptides on markers of oxidative stress and inflammation in adipose tissue explants...
  55. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2013
    ..The proposed research focuses on disruption of the MLL-PAFc interaction with the use of peptides and small chemical compounds...
  56. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2012
    ..The proposed research focuses on disruption of the MLL-PAFc interaction with the use of peptides and small chemical compounds...
  57. VASODEPRESSOR MECHANISMS IN HYPERTENSION
    Carlos M Ferrario; Fiscal Year: 2013
    ..are: Project 1 tests the hypothesis that Ang-( 1-12) constitutes an alternate precursor of angiotensin peptides in the heart and that its regulation and expression from angiotensinogen critically influences the cellular ..
  58. Roles of the mammalian CST complex in DNA replication and chromosome cohesion
    JASON AARON STEWART; Fiscal Year: 2013
    ..be used as an unbiased approach to gain insight into CST function through the identification of novel interacting peptides. This proposed work is innovative because: 1) it addresses the unexpected non-telomere functions of CST;2) it ..
  59. Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia
    Andrew Napper; Fiscal Year: 2012
    ..A recent study showed that peptides containing as few as 10 amino acids derived from the AF9 binding site in AF4 bind to AF9 with low nanomolar ..
  60. ANP Receptor: Molecular approach of signaling mechanisms
    Kailash N Pandey; Fiscal Year: 2013
    ..of pathogenesis whereby malregulation of receptor-mediated cardiac hormones;atrial and brain natriuretic peptides (ANP, BNP) bioactivity could result in abnormalities of fluid volume regulation and blood pressure homeostasis...
  61. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..response, while "high" energy HIFU would be used to ablate the local tumor and release tumor-derived HSPs and peptides for an in situ auto-vaccination...
  62. Effect of Maspin on Corneal Heme-and lymph- angiogenesis
    Sally S Twining; Fiscal Year: 2013
    ..that the phosphorylated form of the N-terminal and/or C-terminal region of maspin inhibits angiogenesis, with peptides of these regions more potent than the intact molecule, and to develop maspin peptides that have potential as anti-..
  63. Crystalline Endolysin Treatment for Tuberculosis in TB/HIV co-infected patients
    BHAMI C SHENOY; Fiscal Year: 2012
    ..tuberculosis resides in macrophages. Cell penetrating peptides (CPP), either engineered in-frame or adsorbed/bound non-covalently to protein substrates, have been used to ..
  64. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2012
    ..Antimicrobial peptides (APs) are key components of the innate immune system, providing first-line inactivation of microbes on the vast ..
  65. GENETIC ANALYSIS OF LUPUS AUTOIMMUNITY
    Judith James; Fiscal Year: 2000
    ..D., Ph.D., have recently demonstrated that normal rabbits immunized with specific short peptides derived from the Sm autoantigen develop high levels of both anti-Sm and anti-nRNP antibodies; the peptides used ..
  66. Bioactive Peptides for Mitigation of AGS and Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2010
    ..Compared to the native GFs, the well-designed peptides with GF binding domain could possess similar activity with attractive properties of peptides being more stable, ..
  67. Role of endogenous opioid peptides in opioid addiction
    LEON TSENG; Fiscal Year: 2005
    DESCRIPTION: (provided by applicant) The endogenous opioid peptides appear to play an important role in modulating the bi-directional motivational effects of opioids...
  68. Developing acid-activated antimicrobial peptides to control dental caries
    Maxwell Anderson; Fiscal Year: 2009
    ..To achieve this goal, we propose to create and perfect a novel set of acid-activated antimicrobial peptides that will only exhibit antimicrobial activity against acid-producing bacteria through activation by the local low ..
  69. Bone Targeting Peptides for the Prevention and Treatment of Infection
    HANNE GRON; Fiscal Year: 2009
    ..proposed Phase I research program, we will therefore attempt to use Affinergy's core technology to identify peptides capable of binding bone, to be used as a component in our bifunctional peptide delivery systems...
  70. REGULATION OF N ARGININE DIBASIC CONVERTASE
    Eva Csuhai; Fiscal Year: 2000
    DESCRIPTION: (Applicant's Abstract) Opioid peptides are a family of endogenous peptides including dynorphins, enkephalins and endorphins. They cause naloxone-sensitive analgesic effects mediated through opiate receptors...
  71. Cone snail venom peptides that modulate zebrafish spinal motor activity
    Joseph Schulz; Fiscal Year: 2009
    The goal of this AREA proposal is to identify the arsenal of peptides the fish- hunting cone snail, Conus catus utilizes to subdue its prey through the rapid modulation of spinal motor activity...
  72. BOMBESIN RECEPTORS IN NORMAL AND NEOPLASTIC TISSUES
    Eliot Spindel; Fiscal Year: 1993
    The bombesin-like peptides are a large family of peptides initially characterized in frog skin, but later found to have wide distribution and potent physiologic effects in mammals...
  73. Stress stimulated peptides in forced use neuroprotection
    Amanda Smith; Fiscal Year: 2003
    ..Stimulation of the HPA axis results in the release of peptides (e.g...
  74. 8th International Symposium for VIP, PACAP & Related Peptides
    Victor May; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The 8th International Symposium on VIP, PACAP, and Related Peptides is planned for September 3 - 8, 2007 at The Equinox Spa and Resort in Manchester, Vermont...
  75. Identification of Novel Alpha Amidated Peptide Hormones
    ANGELO CONSALVO; Fiscal Year: 2007
    ..The identification of novel a-amidated peptides from a biological source has been significantly hindered by lack of a specific assay for this class of bioactive ..
  76. MYELIN BASIC PROTEIN PEPTIDES IN BODY FLUIDS
    JOHN WHITAKER; Fiscal Year: 1993
    The present proposal is to continue research based on the premises that small peptides of myelin basic protein originating from damaged central nervous system myelin enter cerebrospinal fluid, blood and urine of persons with multiple ..
  77. REGULATION OF SECRETION OF POMC PEPTIDES IN BRAIN
    LEONARD KAPCALA; Fiscal Year: 1991
    ..and neuromodulatory effects have been produced in brain by ACTH, alpha-MSH, beta- endorphin, and related peptides derived from processing of their precursor, pro-opiomelanocortin (POMC), which is synthesized by neurons...
  78. A novel peptide therapy for treatment of herpetic stromal keratitis
    Partha S Bhattacharjee; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Two small mimetic peptides derived from two receptor binding regions of the human gene apolipoprotein E (apoE) have been shown, in a few limited studies, to have anti-viral and anti-inflammatory ..
  79. Improved Orthopedic Implant Surface Coatings
    Paul Hamilton; Fiscal Year: 2007
    ..In phase I, we used phage display to identify peptides that bound to titanium with high affinity...
  80. Novel Ovarian Cancer Detection Agents from Phage Display
    SUSAN DEUTSCHER; Fiscal Year: 2009
    ..We previously developed novel in vivo phage display screening techniques to identify peptides that target numerous types of cancers including those of the breast and prostate...
  81. Urinary peptide excretion and onset of puberty
    Stephen Barnes; Fiscal Year: 2009
    ..are relatively short (days-weeks), the proteins in them are subjected to turnover and will appear in blood as peptides. In addition, because of the large-scale redistribution of the body during puberty, peptides from proteins in non-..
  82. Improved Peptide-based Tumor Targeting Agents Using Phage Display
    Susan L Deutscher; Fiscal Year: 2010
    ..Many radiolabeled peptides and small proteins have shown good tumor-targeting propensity in vivo, however their translation into clinically ..
  83. Nanoscale patterning that promotes cell adhesion
    HEATHER MAYNARD; Fiscal Year: 2006
    ..UV) irradiation to selectively chemically transform programmable polymer surfaces to micropattern cell adhesion peptides. A second objective is to translate the technology using low intensity electron beam (e-beam) radiation to ..
  84. OPIATE RECEPTORS EEG SPECTRA TOLERANCE & DEPENDENCE
    Gerald Young; Fiscal Year: 1992
    Dynorphin fragments, mu/delta ligands, delta ligands and certain nonopioid peptides regulate in vivo morphine-induced and beta-endorphin-induced effects...