adenosine triphosphate

Summary

Summary: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.

Top Publications

  1. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
  2. ncbi Molecular physiology of P2X receptors
    R Alan North
    Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield, United Kingdom
    Physiol Rev 82:1013-67. 2002
  3. ncbi ATP mediates rapid microglial response to local brain injury in vivo
    Dimitrios Davalos
    Molecular Neurobiology Program, Department of Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 8:752-8. 2005
  4. pmc Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding
    Stephen G Aller
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, CB105, La Jolla, CA 92037, USA
    Science 323:1718-22. 2009
  5. ncbi Mitochondrial dysfunction and type 2 diabetes
    Bradford B Lowell
    Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Harvard Medical School, Boston, MA 02215, USA
    Science 307:384-7. 2005
  6. ncbi Cellular motility driven by assembly and disassembly of actin filaments
    Thomas D Pollard
    Department of Cellular, Molecular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 112:453-65. 2003
  7. ncbi Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
  8. ncbi The failing heart--an engine out of fuel
    Stefan Neubauer
    Department of Cardiovascular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom
    N Engl J Med 356:1140-51. 2007
  9. ncbi BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    Jeffrey A M Coull
    Division de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    Nature 438:1017-21. 2005
  10. pmc Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
    Michael R Elliott
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 461:282-6. 2009

Detail Information

Publications364 found, 100 shown here

  1. ncbi Cryopyrin activates the inflammasome in response to toxins and ATP
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 440:228-32. 2006
    ..Therefore, cryopyrin is essential for inflammasome activation in response to signalling pathways triggered specifically by ATP, nigericin, maitotoxin, S. aureus or L. monocytogenes...
  2. ncbi Molecular physiology of P2X receptors
    R Alan North
    Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield, United Kingdom
    Physiol Rev 82:1013-67. 2002
    ..In the last case, P2X7 receptor activation stimulates cytokine release by engaging intracellular signaling pathways...
  3. ncbi ATP mediates rapid microglial response to local brain injury in vivo
    Dimitrios Davalos
    Molecular Neurobiology Program, Department of Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 8:752-8. 2005
    ..Thus, extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglial response towards injury...
  4. pmc Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding
    Stephen G Aller
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, CB105, La Jolla, CA 92037, USA
    Science 323:1718-22. 2009
    ..The inward-facing conformation represents an initial stage of the transport cycle that is competent for drug binding...
  5. ncbi Mitochondrial dysfunction and type 2 diabetes
    Bradford B Lowell
    Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Harvard Medical School, Boston, MA 02215, USA
    Science 307:384-7. 2005
    ..Emerging evidence supports the potentially unifying hypothesis that both of these prominent features of type 2 diabetes are caused by mitochondrial dysfunction...
  6. ncbi Cellular motility driven by assembly and disassembly of actin filaments
    Thomas D Pollard
    Department of Cellular, Molecular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 112:453-65. 2003
    ..Profilin catalyzes the exchange of ADP for ATP, refilling the pool of ATP-actin monomers bound to profilin, ready for elongation...
  7. ncbi Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
    ..These metabolic alterations provide a mechanistic explanation for the growth advantage and apoptotic resistance of tumor cells...
  8. ncbi The failing heart--an engine out of fuel
    Stefan Neubauer
    Department of Cardiovascular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom
    N Engl J Med 356:1140-51. 2007
  9. ncbi BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    Jeffrey A M Coull
    Division de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    Nature 438:1017-21. 2005
    ..Blocking this microglia-neuron signalling pathway may represent a therapeutic strategy for treating neuropathic pain...
  10. pmc Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
    Michael R Elliott
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 461:282-6. 2009
    ....
  11. ncbi Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
    Simon A Hawley
    Division of Molecular Physiology University of Dundee, Dundee, Scotland, United Kingdom
    Cell Metab 2:9-19. 2005
    ..Our results suggest a potential Ca(2+)-dependent neuroprotective pathway involving phosphorylation and activation of AMPK by CaMKKbeta...
  12. ncbi p53 regulates mitochondrial respiration
    Satoaki Matoba
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 312:1650-3. 2006
    ..That SCO2 couples p53 to mitochondrial respiration provides a possible explanation for the Warburg effect and offers new clues as to how p53 might affect aging and metabolism...
  13. pmc Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    Wenwei Hu
    Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Proc Natl Acad Sci U S A 107:7455-60. 2010
    ..These results demonstrated that as a unique p53 target gene, GLS2 is a mediator of p53's role in energy metabolism and antioxidant defense, which can contribute to its role in tumor suppression...
  14. pmc Structure, function, and evolution of bacterial ATP-binding cassette systems
    Amy L Davidson
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Microbiol Mol Biol Rev 72:317-64, table of contents. 2008
    ..These advances are also important for elucidating the mechanism of action of eukaryotic ABC proteins, because functional defects in many of them are responsible for severe human inherited diseases...
  15. ncbi Cooperation and competition in the evolution of ATP-producing pathways
    T Pfeiffer
    Friedrich Miescher Institute, Post Office Box 2543, CH-4002 Basel, Switzerland, , D-13092 Berlin, Germany
    Science 292:504-7. 2001
    Heterotrophic organisms generally face a trade-off between rate and yield of adenosine triphosphate (ATP) production...
  16. ncbi Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization
    Ahmet Yildiz
    Center for Biophysics and Computational Biology, University of Illinois, Urbana Champaign, IL 61801, USA
    Science 300:2061-5. 2003
    ..that moves processively on actin, with the center of mass moving approximately 37 nanometers for each adenosine triphosphate hydrolyzed...
  17. pmc Neuromodulation by extracellular ATP and P2X receptors in the CNS
    Baljit S Khakh
    Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1751, USA
    Neuron 76:51-69. 2012
    ....
  18. pmc SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    Matthew D Hirschey
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    Nature 464:121-5. 2010
    ..These findings identify acetylation as a novel regulatory mechanism for mitochondrial fatty-acid oxidation and demonstrate that SIRT3 modulates mitochondrial intermediary metabolism and fatty-acid use during fasting...
  19. ncbi Structure and mechanism of helicases and nucleic acid translocases
    Martin R Singleton
    Macromolecular Structure and Function Laboratory, The London Research Institute, London WC2A 3PX, United Kingdom
    Annu Rev Biochem 76:23-50. 2007
    ..As a result, each superfamily is subdivided, where appropriate, on the basis of mechanistic understanding, which we hope will provide a framework for classification of new superfamily members as they are discovered and characterized...
  20. pmc Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis
    Faraaz B Chekeni
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 467:863-7. 2010
    ..Collectively, these data identify PANX1 as a plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechanism of PANX1 activation by caspases...
  21. pmc Molecular mechanism of ATP binding and ion channel activation in P2X receptors
    Motoyuki Hattori
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Nature 485:207-12. 2012
    ..The structural delineation of the ATP-binding site and the ion channel pore, together with the conformational changes associated with ion channel gating, will stimulate development of new pharmacological agents...
  22. ncbi SNAP receptors implicated in vesicle targeting and fusion
    T Sollner
    Rockefeller Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Nature 362:318-24. 1993
    ....
  23. ncbi Astrocytic purinergic signaling coordinates synaptic networks
    Olivier Pascual
    Department of Neuroscience, Conte Center for Integration at the Tripartite Synapse, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 310:113-6. 2005
    ..By releasing adenosine triphosphate, which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission, thereby enhancing ..
  24. ncbi Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa
    Toru Sengoku
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    Cell 125:287-300. 2006
    ..This mechanism, which differs from those for canonical translocating helicases, may enable the targeted modulation of intricate RNA structures...
  25. ncbi AMPK is a direct adenylate charge-regulated protein kinase
    Jonathan S Oakhill
    Department of Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia
    Science 332:1433-5. 2011
    ..AMPK is an αβγ heterotrimer activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations...
  26. pmc Structure of mammalian AMPK and its regulation by ADP
    Bing Xiao
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 472:230-3. 2011
    ..From our biochemical and structural data we develop a model for how the energy status of a cell regulates AMPK activity...
  27. pmc A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
    Bong Hyun Ahn
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:14447-52. 2008
    ..These results implicate protein acetylation as an important regulator of Complex I activity and demonstrate that Sirt3 functions in vivo to regulate and maintain basal ATP levels...
  28. ncbi Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c
    X Liu
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cell 86:147-57. 1996
    ..Cells undergoing apoptosis in vivo showed increased release of cytochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c...
  29. ncbi Purine and pyrimidine receptors
    G Burnstock
    Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK
    Cell Mol Life Sci 64:1471-83. 2007
    ..P2Y receptors are G protein-coupled receptors, and eight subtypes have been cloned and characterised to date...
  30. ncbi Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
    M J L Bours
    Maastricht University, Department of Epidemiology, Nutrition and Toxicology Research Institute Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Pharmacol Ther 112:358-404. 2006
    ..Purinergic signaling thus contributes to the fine-tuning of inflammatory and immune responses in such a way that the danger to the host is eliminated efficiently with minimal damage to healthy tissues...
  31. ncbi Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses
    R Rizzuto
    Department of Biomedical Sciences and the National Research Council Center for the Study of Biomembranes, University of Padova, Via Colombo 3, 35121 Padova, Italy
    Science 280:1763-6. 1998
    ..These results emphasize the importance of cell architecture and the distribution of organelles in regulation of Ca2+ signaling...
  32. ncbi The AMP-activated protein kinase pathway--new players upstream and downstream
    D Grahame Hardie
    Division of Molecular Physiology, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK
    J Cell Sci 117:5479-87. 2004
    ....
  33. pmc Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
    Simon A Hawley
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Cell Metab 11:554-65. 2010
    ..Our approaches distinguish at least six different mechanisms for AMPK activation and confirm that the widely used antidiabetic drug metformin activates AMPK by inhibiting mitochondrial respiration...
  34. pmc Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor
    Amy E Palmer
    Department of Pharmacology and Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0647, USA
    Proc Natl Acad Sci U S A 101:17404-9. 2004
    ....
  35. ncbi DNA topoisomerases: harnessing and constraining energy to govern chromosome topology
    Allyn J Schoeffler
    Department of Molecular and Cell Biology, California Institute for Quantitative Biology, University of California Berkeley, Berkeley, CA, USA
    Q Rev Biophys 41:41-101. 2008
    ....
  36. ncbi Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures
    Zhucheng Chen
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 453:489-4. 2008
    ..The underwound, stretched filament conformation probably evolved to destabilize the donor duplex, freeing the complementary strand for homology sampling...
  37. ncbi Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
    Giovanna Borsellino
    Laboratory of Neuroimmunology, Fondazione Santa Lucia, Rome, Italy
    Blood 110:1225-32. 2007
    ..Thus, in humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease...
  38. ncbi KATP channels as molecular sensors of cellular metabolism
    Colin G Nichols
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 440:470-6. 2006
    ..In parallel, the uncovering of disease-causing mutations of K(ATP) has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function...
  39. ncbi ATP drives lamina propria T(H)17 cell differentiation
    Koji Atarashi
    Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nature 455:808-12. 2008
    ..These observations highlight the importance of commensal bacteria and ATP for T(H)17 differentiation in health and disease, and offer an explanation of why T(H)17 cells specifically present in the intestinal lamina propria...
  40. ncbi Structure of a bacterial multidrug ABC transporter
    Roger J P Dawson
    Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    Nature 443:180-5. 2006
    ....
  41. pmc A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice
    Annette Nicke
    Department of Neurochemistry, Max Planck Institute MPI for Brain Research, Deutschordenstrasse 46, Frankfurt 60528, Germany
    J Biol Chem 284:25813-22. 2009
    ..Its presence in one of the P2X7(-/-) strains has important implications for our understanding of the role of this receptor in health and disease...
  42. ncbi ATP signaling is crucial for communication from taste buds to gustatory nerves
    Thomas E Finger
    Rocky Mountain Taste and Smell Center, Aurora CO 80045, USA
    Science 310:1495-9. 2005
    ..Finally, stimulation of taste buds in vitro evokes release of ATP. Thus, ATP fulfils the criteria for a neurotransmitter linking taste buds to the nervous system...
  43. ncbi Signaling at purinergic P2X receptors
    Annmarie Surprenant
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Annu Rev Physiol 71:333-59. 2009
    ..We review our current understanding of the molecular properties of P2X receptors, including how this understanding is informed by the identification of distantly related P2X receptors in simple eukaryotes...
  44. ncbi Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
    Annett Hahn-Windgassen
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 60607, USA
    J Biol Chem 280:32081-9. 2005
    ..We propose that the activation of mTOR by Akt-mediated cellular energy and inhibition of AMPK is the predominant pathway by which Akt activates mTOR in vivo...
  45. ncbi ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors
    Yu Chen
    Department of Surgery, University of California San Diego, San Diego, CA 92103, USA
    Science 314:1792-5. 2006
    ..We find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of the cell surface to amplify chemotactic signals and direct cell orientation ..
  46. pmc ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages
    Cristiane M Cruz
    School of Natural Sciences, University of California, Merced, California 95344, USA
    J Biol Chem 282:2871-9. 2007
    ....
  47. pmc SLP-2 is required for stress-induced mitochondrial hyperfusion
    Daniel Tondera
    Department of Cell Biology, University of Geneva, Geneva, Switzerland
    EMBO J 28:1589-600. 2009
    ..In the absence of SLP-2, L-OPA1 is lost and SIMH is prevented. SIMH is accompanied by increased mitochondrial ATP production and represents a novel adaptive pro-survival response against stress...
  48. ncbi Liaisons dangereuses: P2X(7) and the inflammasome
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Via Borsari, 46, Ferrara, Italy
    Trends Pharmacol Sci 28:465-72. 2007
    ....
  49. pmc Crystal structure of the ATP-gated P2X(4) ion channel in the closed state
    Toshimitsu Kawate
    Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Oregon 97239, USA
    Nature 460:592-8. 2009
    ..We define the location of three non-canonical, intersubunit ATP-binding sites, and suggest that ATP binding promotes subunit rearrangement and ion channel opening...
  50. ncbi Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku and National Public Health Institute, Turku, Finland
    Biochim Biophys Acta 1783:673-94. 2008
    ..This review summarizes recent advances in this rapidly evolving field, with particular emphasis on the nucleotide-releasing and purine-converting pathways in the vasculature...
  51. ncbi Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation
    Yan Qu
    Physiological Chemistry Department, Genentech, Inc, South San Francisco, CA 94080, USA
    J Immunol 186:6553-61. 2011
    ..These data are consistent with pannexin-1 liberating ATP and other yet to be defined "find me" signals necessary for macrophage recruitment to apoptotic cells...
  52. pmc Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity
    Felix C Weber
    Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, D 79104 Freiburg, Germany
    J Exp Med 207:2609-19. 2010
    ..In this study, we demonstrate that mice lacking the adenosine triphosphate (ATP) receptor P2X(7) are resistant to contact hypersensitivity (CHS)...
  53. ncbi The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity
    S P Crouch
    Medical Research Centre, City Hospital, Nottingham, UK
    J Immunol Methods 160:81-8. 1993
    b>Adenosine triphosphate (ATP) bioluminescence was used to determine whether there was a linear relationship between cultured cell number and measured luminescence using the luciferin-luciferase reaction...
  54. pmc Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase
    Patrizia Pellegatti
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy
    PLoS ONE 3:e2599. 2008
    ....
  55. ncbi Molecular biology of adenosine triphosphate-sensitive potassium channels
    L Aguilar-Bryan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocr Rev 20:101-35. 1999
    ....
  56. pmc Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins
    Frédéric Legros
    Institut National de la Santé et de la Recharche Médicale U523, Institut de Myologie, Groupe Hospitalier Pitie Salpetriere, 75651 Paris, France
    Mol Biol Cell 13:4343-54. 2002
    ..These results show that human mitochondria represent a single cellular compartment whose exchanges and interconnectivity are dynamically regulated by the balance between continuous fusion and fission reactions...
  57. ncbi Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels
    Ursula Schenk
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Sci Signal 1:ra6. 2008
    ..receptor (TCR) stimulation results in the influx of Ca(2+), which is buffered by mitochondria and promotes adenosine triphosphate (ATP) synthesis...
  58. pmc ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way
    Alessandra Piccini
    Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 105:8067-72. 2008
    ..Thus, stimuli acting on different pathogen-sensing receptors converge on a common pathway where ATP externalization is the first step in the cascade of events leading to inflammasome activation and IL-1beta and IL-18 secretion...
  59. ncbi Ischemia opens neuronal gap junction hemichannels
    Roger J Thompson
    Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Science 312:924-7. 2006
    ..Both the current and dye flux were blocked by inhibitors of hemichannels. Therefore, hemichannel opening contributes to the profound ionic dysregulation during stroke and may be a ubiquitous component of ischemic neuronal death...
  60. ncbi ABC transporters: from microorganisms to man
    C F Higgins
    Imperial Cancer Research Fund Laboratories, University of Oxford, John Radcliffe Hospital, England
    Annu Rev Cell Biol 8:67-113. 1992
  61. pmc Astrocytes control breathing through pH-dependent release of ATP
    Alexander V Gourine
    Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, UK
    Science 329:571-5. 2010
    ..responded to physiological decreases in pH with vigorous elevations in intracellular Ca2+ and release of adenosine triphosphate (ATP)...
  62. pmc Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy
    Saroj P Mathupala
    Department of Neurological Surgery and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, United States
    Semin Cancer Biol 19:17-24. 2009
    ..This leads to very rapid ATP depletion and tumor destruction without harm to the animals. This review focuses on the multiple roles played by HK-2 in cancer and its potential as a metabolic target for complete cancer destruction...
  63. ncbi Caspase activation by anticancer drugs: the caspase storm
    Zhimin Tao
    Department of Chemistry, Syracuse University, 1 014 CST, Syracuse, New York 13244, USA
    Mol Pharm 4:583-95. 2007
    ..Exposure of the cells to all of the drugs studied led to impaired cellular respiration and decreased cellular ATP, concomitant with caspase activation. Thus, the mitochondria are rapidly targeted by active caspases...
  64. ncbi The 2.8 Å crystal structure of the dynein motor domain
    Takahide Kon
    Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nature 484:345-50. 2012
    ..We also identify a long-range allosteric communication pathway between the primary ATPase and the microtubule-binding sites. Our work provides a framework for understanding the mechanism of dynein-based motility...
  65. pmc Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators
    Hiromi Imamura
    Precursory Research for Embryonic Science, Japan Science and Technology Agency, 5 Sanbancho, Chiyoda ku, Tokyo 102 0075, Japan
    Proc Natl Acad Sci U S A 106:15651-6. 2009
    ..This was also confirmed by an experiment using oligomycin A, an inhibitor of F(o)F(1)-ATP synthase. In addition, it was demonstrated that HeLa cells change ATP-generating pathway in response to changes of nutrition in the environment...
  66. pmc Pannexin 1 in erythrocytes: function without a gap
    Silviu Locovei
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, P O Box 016430, Miami, FL 33101, USA
    Proc Natl Acad Sci U S A 103:7655-9. 2006
    ..Furthermore, under conditions of ATP release, erythrocytes took up fluorescent tracer molecules permeant to gap junction channels...
  67. ncbi P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia
    Elena Adinolfi
    Department of Experimental and Diagnostic Medicine, Section of Medical Genetics and General Pathology, University of Ferrara, Italy
    Blood 99:706-8. 2002
    ..Finally, incubation in the presence of extracellular adenosine triphosphate decreased spontaneous proliferation of lymphocytes from patients affected with the evolutive variant but ..
  68. pmc Probenecid, a gout remedy, inhibits pannexin 1 channels
    William Silverman
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33101, USA
    Am J Physiol Cell Physiol 295:C761-7. 2008
    ..Probenecid did not affect channels formed by connexins. Thus probenecid allows for discrimination between channels formed by connexins and pannexins...
  69. pmc Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility
    M F Carlier
    Dynamique du Cytosquelette, Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    J Cell Biol 136:1307-22. 1997
    ..In conclusion, the function of ADF is not to sequester G-actin. ADF uses ATP hydrolysis in actin assembly to enhance filament dynamics...
  70. pmc Immune cell regulation by autocrine purinergic signalling
    Wolfgang G Junger
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Rev Immunol 11:201-12. 2011
    ..This Review focuses on the roles of autocrine purinergic signalling in the regulation of both innate and adaptive immune responses and discusses the potential of targeting purinergic receptors for treating immune-mediated disease...
  71. ncbi Amyloid β-induced death in neurons involves glial and neuronal hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago 6513677, Chile
    J Neurosci 31:4962-77. 2011
    ..Consequently, this work opens novel avenues for alternative treatments that target glial cells and neurons to maintain neuronal survival in the presence of Aβ...
  72. pmc Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria
    Ian N Watt
    The Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge, CB2 0XY, UK
    Proc Natl Acad Sci U S A 107:16823-7. 2010
    ..Therefore, in about 50,000 vertebrate species, and probably in many or all of the two million invertebrate species, 2.7 protons are required by the F-ATPase to make each ATP molecule...
  73. ncbi Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
    P D Jeffrey
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 376:313-20. 1995
    ..These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft...
  74. ncbi DNA replication in eukaryotic cells
    Stephen P Bell
    Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA
    Annu Rev Biochem 71:333-74. 2002
    ..We emphasize recent progress in determining the function of the different replication factors once they have been assembled at the origin...
  75. pmc Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase
    Kambiz N Alavian
    Department of Internal Medicine, Yale University, New Haven, Connecticut 06520, USA
    Nat Cell Biol 13:1224-33. 2011
    ..Our findings indicate that increased mitochondrial efficiency contributes to the enhanced synaptic efficacy found in Bcl-x(L)-expressing neurons...
  76. pmc Crystal structure of the dynein motor domain
    Andrew P Carter
    Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Science 331:1159-65. 2011
    ..The arrangement of these elements provides clues as to how adenosine triphosphate-driven conformational changes might be transmitted across the motor domain.
  77. ncbi Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits
    M L Phelan
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Mol Cell 3:247-53. 1999
    ..The addition of INI1, BAF155, and BAF170 to BRG1 increases remodeling activity to a level comparable to that of the whole hSWI/SNF complex. These data define the functional core of the hSWI/SNF complex...
  78. pmc Connexin 43 hemichannels are permeable to ATP
    Jian Kang
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 28:4702-11. 2008
    ..Furthermore, a putative Cx43 hemichannel with characteristics identical to the Cx43 hemichannel in C6 cells was identified in the membrane of hippocampal astrocytes in acutely prepared slices...
  79. pmc The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells
    Zhongyan Zhang
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Biol Cell 22:2235-45. 2011
    ..Consequently, mice lacking Opa1 in beta cells develop hyperglycemia. The data suggest that the function of Opa1 in the maintenance of the electron transport chain is physiologically relevant in beta cells...
  80. pmc Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia
    X Zhang
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Proc Natl Acad Sci U S A 104:9864-9. 2007
    ..These results also suggest that, contrary to the conventional view, neuronal somata have a significant role in cell-cell signaling...
  81. ncbi ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors
    Ursula Schenk
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Sci Signal 4:ra12. 2011
    Extracellular nucleotides are pleiotropic regulators of mammalian cell function. Adenosine triphosphate (ATP) released from CD4(+) helper T cells upon stimulation of the T cell receptor (TCR) contributes in an autocrine manner to the ..
  82. pmc ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 118:826-40. 2011
    ....
  83. ncbi CNS energy metabolism as related to function
    A Ames
    Neurosurgical Service, Massachusetts General Hospital, Boston, MA, USA
    Brain Res Brain Res Rev 34:42-68. 2000
    ..It seems probable that the supply of energy may impose a limit on the activity of a neuron under normal conditions. A number of mechanisms have evolved to reduce activity when energy levels are diminished...
  84. pmc Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress
    X Liu
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cell Death Differ 18:1561-72. 2011
    ..Thus, the metabolic stress during hypoxia-reoxygenation alters mitochondrial morphology by inducing distinct patterns of mitochondrial dynamics, which includes processes that could aid mitochondrial adaptation and functional recovery...
  85. ncbi The P-glycoprotein multidrug transporter
    Frances J Sharom
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    Essays Biochem 50:161-78. 2011
    ..Details of the steps involved in the drug-transport process, and how it is coupled to ATP hydrolysis, remain the object of intensive study...
  86. pmc Structural interpretation of P2X receptor mutagenesis studies on drug action
    Richard J Evans
    Cell Physiology and Pharmacology, University of Leicester, Leicester, UK
    Br J Pharmacol 161:961-71. 2010
    ..These studies are discussed with reference to the crystal to provide a structural interpretation of the molecular basis of drug action...
  87. pmc P2X1 receptor mobility and trafficking; regulation by receptor insertion and activation
    Ulyana Lalo
    Department of Cell Physiology and Pharmacology, Henry Wellcome Building, University of Leicester, Leicester, UK
    J Neurochem 113:1177-87. 2010
    ..In functional studies both brefeldin A and dynasore increased the recovery time from desensitisation. Taken together these studies demonstrate for the first time an important role of receptor recycling on P2X1 receptor responsiveness...
  88. ncbi Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
    Issam Ben Sahra
    Faculte de Medecine, Universite de Nice Sophia Antipolis, Institut Signalisation et Pathologies, Institut National de la Sante et de la Recherche Medicale, U895, Nice, France
    Cancer Res 70:2465-75. 2010
    ..Our study reinforces the growing interest of metabolic perturbators in cancer therapy and highlights the potential use of the combination of metformin and 2DG as an anticancerous treatment...
  89. ncbi The ADP and ATP transport in mitochondria and its carrier
    Martin Klingenberg
    Institut Physiologische Chemie der Universität München, Germany
    Biochim Biophys Acta 1778:1978-2021. 2008
    ..Being a snapshot of an extreme abortive "c-state" the actual mechanism still remains a conjecture...
  90. ncbi ABC transporters: physiology, structure and mechanism--an overview
    C F Higgins
    MRC Clinical Sciences Centre, Imperial College, London, UK
    Res Microbiol 152:205-10. 2001
    ..The family is described and a general overview of the structure and function of these transporters is presented...
  91. ncbi Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis
    Anil Koul
    Departments of Antimicrobial Research and Functional Genomics, Johnson and Johnson, Turnhoutseweg 30, B 2340 Beerse, Belgium
    J Biol Chem 283:25273-80. 2008
    ....
  92. ncbi Glucose-stimulated signaling pathways in biphasic insulin secretion
    Susanne G Straub
    Cornell University, Ithaca, New York, USA
    Diabetes Metab Res Rev 18:451-63. 2002
    ..In the former, enhanced glucose metabolism increases the cellular adenosine triphosphate/adenosine diphosphate (ATP/ADP) ratio, closes KATP channels and depolarizes the cell...
  93. ncbi P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis
    Carlos Matute
    Departamento de Neurociencias, Universidad del Pais Vasco, 48940 Leioa, Spain
    J Neurosci 27:9525-33. 2007
    ..Thus, P2X(7) receptor antagonists may be beneficial for the treatment of MS...
  94. ncbi Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling
    Jan P Erzberger
    Division of Biochemistry and Molecular Biology, Molecular and Cell Biology Department, 327B Hildebrand Hall 3206, University of California, Berkeley, California 94720, USA
    Nat Struct Mol Biol 13:676-83. 2006
    ..Eukaryotic and archaeal initiators also have the structural elements that promote open-helix formation, indicating that a spiral, open-ring AAA+ assembly forms the core element of initiators in all domains of life...
  95. ncbi Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
    Eva Pebay-Peyroula
    Institut de Biologie Structurale, UMR 5075 CEA CNRS Université Joseph Fourier, 41 rue Jules Horowitz, F 38027, Grenoble Cedex 1, France
    Nature 426:39-44. 2003
    ..Our structure, together with earlier biochemical results, suggests that transport substrates bind to the bottom of the cavity and that translocation results from a transient transition from a 'pit' to a 'channel' conformation...
  96. ncbi Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase
    John C W Randell
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell 21:29-39. 2006
    ..Importantly, these coordinated yet distinct functions of ORC and Cdc6 ensure the correct temporal and spatial regulation of pre-RC formation...
  97. ncbi Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    Ira E Clark
    Nature 441:1162-6. 2006
    ..The role of the pink1-parkin pathway in regulating mitochondrial function underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis...
  98. ncbi Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins
    Ivar Ilves
    Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 37:247-58. 2010
    ..The onset of DNA replication and unwinding may thus occur through allosteric changes in MCM2-7 affected by the association of these ancillary factors...
  99. pmc Structural basis of HIV-1 resistance to AZT by excision
    Xiongying Tu
    Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA
    Nat Struct Mol Biol 17:1202-9. 2010
    ..Thus, the resistance mutations create a high-affinity ATP-binding site. The structure of the site provides an opportunity to design inhibitors of AZT-monophosphate excision...
  100. ncbi Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells
    Paolo Salerno
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, 80131 Naples, Italy
    J Clin Endocrinol Metab 95:450-5. 2010
    ..The V600E mutation accounts for the vast majority of thyroid carcinoma-associated BRAF mutations...
  101. pmc Ca(2+) transfer from the ER to mitochondria: when, how and why
    Rosario Rizzuto
    Dept Biomedical Sciences, University of Padua, Via Colombo 3, Padua 35121, Italy
    Biochim Biophys Acta 1787:1342-51. 2009
    ..Despite the rapid progress carried out in the latest years, a deeper molecular understanding is still needed to unlock the secrets of Ca(2+) signaling machinery...

Research Grants64

  1. Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant Depression
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..These include beta-nucleoside triphosphate (!-NTP;largely adenosine triphosphate, or ATP) and phosphocreatine (PCr)...
  2. PET Imaging of Myocardial Oxidative Stress in T2DM
    KOORESH ISAAC SHOGHI; Fiscal Year: 2013
    ..using [11]C-palmitate) with PET;myocardial energetics as defined by the phosphocreatine and adenosine triphosphate concentrations and their ratio and creatine kinase flux using [31]P-MRS;and left ventricular structure/ ..
  3. Testing the efficacy of PGC-1alpha as a therapeutic target for Parkinson's diseas
    HANS BUELER; Fiscal Year: 2010
    ..detoxifying reactive oxygen species, protecting cells against death caused by chronic reductions in adenosine triphosphate (ATP) synthesis and oxidative stress...
  4. Study of Energy and Aging
    Steven Cummings; Fiscal Year: 2009
    ..Studies of mitochondrial function and adenosine triphosphate (ATP) energy production have been, to date, too small to understand the relative roles of the various ..
  5. In vivo Studies of Creatine Kinase Kinetics by 31P Magnetization Transfer MRS
    Adil Bashir; Fiscal Year: 2013
    ..Heart uses chemical energy in the form of adenosine triphosphate (ATP) to support systolic and diastolic function...
  6. Intraocular pressure regulation via ATP-sensitive potassium channels
    Michael F Romero; Fiscal Year: 2013
    ..abstract_text> ..
  7. A NEW TECHNIQUE FOR TREATING HEMORRHAGIC SHOCK
    Sufan Chien; Fiscal Year: 2013
    ..is a hypovolemic condition in which oxygen delivery to the body is inadequate for the generation of the adenosine triphosphate (ATP) and adenosine diphosphate (ADP) necessary to maintain the function and structural integrity of ..
  8. Regulation of Muscle ATP Synthase Beta Subunit Metabolism in Obesity
    Christos S Katsanos; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obesity is associated with reduced adenosine triphosphate (ATP) turnover in skeletal muscle...
  9. MAGNETIZATION TRANSFER MRS IN METHAMPHETAMINE USERS RESUBMISSION
    Young Hoon Sung; Fiscal Year: 2013
    ..dysfunction related to creatine kinase (CK), the enzyme that is directly involved in regeneration of adenosine triphosphate (ATP) from PCr...
  10. MICROTUBULE MOTORS STUDIED ON A MOLECULAR SCALE
    Steven M Block; Fiscal Year: 2010
    ..The largest class of motor proteins is fueled by adenosine triphosphate (ATP) and includes members of the myosin, dynein, and kinesin "superfamilies" of proteins...
  11. Energy-based cold tolerance in genetically tractable eukaryotic systems
    Daniel H Shain; Fiscal Year: 2010
    ..e., ATP;5'adenosine triphosphate), in an apparent mechanism to off-set inherent reductions in molecular motion (and thus lethargy and death)..
  12. Purinergic Mechanisms in Homeostatic Sleep Control
    Radhika Basheer; Fiscal Year: 2013
    ..The purine nucleotide adenosine triphosphate (ATP) is released into extracellular space as a co-transmitter and via gliotransmission during neuronal ..
  13. Noninvasive Study of Cerebral ATP Metabolism, Bioenergetics and Brain Function
    Wei Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Energy metabolism is a fundamental process of life. Adenosine triphosphate (ATP) provides energy for most cellular activities in resting and activated brain...
  14. Multiscale Interaction of Pulmonary Gas Flow and Lung Tissue Mechanics
    Ching Long Lin; Fiscal Year: 2013
    ..motivating this work is that lung diseases alter mechanical force, which then alters stress-mediated adenosine triphosphate nucleotide release, disturbs periciliary liquid (PCL) water homeostasis, and weakens the integrated airway ..
  15. Mechanisms of Endothelial Cell Hyperpolarization
    Sean P Marrelli; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Adenosine triphosphate (ATP) is a potent regulator of vascular tone in the cerebral circulation...
  16. INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDS
    Sufan Chien; Fiscal Year: 2010
    ..Our central hypoth- esis is that wound tissue hypoxia results in depletion of adenosine triphosphate (ATP), which is the fundamental cause of non-healing chronic wounds, and a direct intracellular ATP ..
  17. EXPLOITATION OF THE KATP CHANNEL OPENER DIAZOXIDE DURING CARDIAC SURGERY
    Jennifer S Lawton; Fiscal Year: 2013
    ..These structural and functional derangements may be eliminated by the addition of an adenosine triphosphate -sensitive potassium (KATP) channel opener diazoxide which is known to mimic ischemic preconditioning and ..
  18. Univ of Maryland Baltimore Interdisciplinary Research Center in Benign Urology
    SUSAN F KEAY; Fiscal Year: 2011
    ..polyamines, expression of tight junction proteins, and cellular mechanosensitivity measured by adenosine triphosphate (ATP) release in response to hypo-osmotic and chemical stimuli...
  19. The adenosine system in viral reservoir persistence
    Jay Rappaport; Fiscal Year: 2013
    ..b>Adenosine triphosphate (ATP) is a potent immune stimulant, acting via P2-type receptors on immune cells...
  20. Molecular Modulation of Catalytic Sites of Escherichia coli F1Fo ATP Synthase
    Zulfiqar Ahmad; Fiscal Year: 2009
    ..means of cell energy production in animals, plants, and almost all microorganisms in the form of adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate (Pi)...
  21. Structural mechanics of MsbA family ABC transporters
    John Hunt; Fiscal Year: 2009
    ..most commonly employed by cells to drive the active transport of solutes across membranes using adenosine triphosphate (ATP) as an energy source...
  22. Role of ABCA7 in iNKT development and function and its impact on atherosclerosis
    Heba Nowyhed; Fiscal Year: 2013
    ..ABCA7, an adenosine triphosphate binding cassette transporter, has been shown to be upregulated in immune cells in response to statins...
  23. Gap Junction and Bone Cell Responses to Physical Signals
    Henry J Donahue; Fiscal Year: 2010
    ..We propose that gap junctional intercellular communication and release of nucleotides, specifically adenosine triphosphate (ATP), from osteocytic or osteoblastic cells, are both essential to maximize bone cell response to the ..
  24. Role and Mechanism of ATP Hydrolysis in Actin
    Isaiah Sumner; Fiscal Year: 2012
    ..Actin binds to adenosine triphosphate (ATP) and will also catalyze its hydrolysis to adenosine diphosphate (ADP)...
  25. ONTOGENY AND HORMONAL CONTROL OF CARDIAC NADH SHUTTLES
    Thomas Scholz; Fiscal Year: 2001
    Substrates for myocardial adenosine triphosphate (ATP) production shift from glucose and lactate to fatty acids in the developing heart...
  26. Noninvasive Sensors of Metabolic Activity
    John Miller; Fiscal Year: 2009
    ..The chemical currency of energy and metabolism is adenosine triphosphate (ATP), produced by enzyme complexes within mitochondria...
  27. STUDIES ON ADENOSINE TRIPHOSPHATE TRANSPHOSPHORYLASES
    THOMAS ALBER; Fiscal Year: 1990
    ....
  28. MR Studies of Myocardial Creatine Kinase Metabolism
    PAUL BOTTOMLEY; Fiscal Year: 2007
    ..spectroscopy (MRS) with phosphorus (31P) is uniquely able to noninvasively assess key metabolites, adenosine triphosphate (ATP) and phosphocreatine (PCr), in the heart...
  29. PHOSPHORUS MRS OF NORMAL HUMAN MASSETER MUSCLE
    Octavia Plesh; Fiscal Year: 1991
    ..aims of the proposed study are: 1) to obtain normative data on high-energy phosphorus metabolites such as adenosine triphosphate (ATP), phosphocreatine (PCr), and inorganic phosphate (Pi) as well as pH in healthy human masseter muscles ..
  30. Role of Erythrocytes in Circulatory Control
    Randy Sprague; Fiscal Year: 2004
    ..nitric oxide (NO) synthesis in the lung and that mechanical deformation of RBCs results in the release of adenosine triphosphate (ATP), a stimulus for endothelial NO synthesis, suggested a novel mechanism for the control of vascular ..
  31. [Ca2+]i and Secretory Dynamics in Parotid Acinar Cells
    David Yule; Fiscal Year: 2007
    ..Ca2+ signals can also be generated by an alternative, largely independent ionotropic process following adenosine triphosphate (ATP) activation of the P2X class of Ca2+ permeable ion channels...
  32. ATP DEGRADATION SYSTEM IN ACUTE TISSUE INJURY
    Cyril Grum; Fiscal Year: 1991
    ..One system likely to play a role in acute tissue injury is the adenosine triphosphate (ATP) degradation cascade and its associated enzyme xanthine oxidase...
  33. Diagnosis of Cardiac Viability by Functional Ultrasound
    Marek Belohlavek; Fiscal Year: 2005
    ..The accepted measures are a) adenosine triphosphate turnover, b) creatine phosphate/ inorganic phosphate ratio, and c) creatine kinase activity...
  34. Host Cell Killing by EPEC: Central Role in Pathogenesis
    JOHN CRANE; Fiscal Year: 2005
    ..One of the non-apoptotic features of EPEC-mediated killing is release of adenosine triphosphate (ATP) from the host cell. Once released, ATP is broken down to other adenine nucleotides and adenosine...
  35. NONINVASIVE HIGH ENERGY PHOSPHATE IMAGING
    PAUL BOTTOMLEY; Fiscal Year: 1999
    ..spectroscopy (MRS) is unique in its ability to provide non-invasive access to key HEP metabolites such as adenosine triphosphate (ATP), the body's essential energy currency, and phosphocreatine (PCr), a key energy reserve...
  36. MECHANISM OF THE NA, K- ION TRANSPORT ATPASE
    Robert Post; Fiscal Year: 1990
    ..of the enzyme will be monitored either by the reactivity of the phosphoenzyme intermediate formed from adenosine triphosphate or by the fluorescence intensity of a fluorescent probe covalently bound to the enzyme at a specific ..
  37. MECHANISM OF KINESIN ATPASE
    David Hackney; Fiscal Year: 2002
    ..The energy that drives the movement of kinesin is provided by the hydrolysis of adenosine triphosphate (ATP)...
  38. STRUCTURE/FUNCTION STUDIES OF LYS2P OF CANDIDA ALBICANS
    J Bhattacharjee; Fiscal Year: 1999
    ..These mutants will be employed in in vivo transformation experiments and in vitro enzyme assays to determine the specific physiological roles of the mutated amino acid residues in the complex AAR reaction. ..
  39. ANESTHETICS AND CARDIOPROTECTIVE SIGNAL TRANSDUCTION
    Judy Kersten; Fiscal Year: 2001
    ..The role of adenosine triphosphate-regulated potassium (KATP) channels, adenosine receptors and protein kinase C activation by volatile ..
  40. ETHANOL EFFECTS ON ISCHEMIC MYOCARDIUM
    PAUL PAGEL; Fiscal Year: 2000
    The long-term objective of this developmental proposal is to determine the role of adenosine triphosphate-regulated potassium (K-ATP) channels in the antiischemic actions of chronic, modest ethanol exposure in canine models of ischemia ..
  41. TZD Treatment of Cocaine Toxicity
    Guy Weinberg; Fiscal Year: 2005
    ..such as lidocaine, impair function of mitochondria, the intracellular organelles that synthesize adenosine triphosphate (ATP), the molecule that serves cells' energy needs...
  42. REGULATION OF MEMBRANE MEDIATED MUSCLE DEGENERATION
    Syamal Bhattacharya; Fiscal Year: 1992
    ....
  43. Depression, Epinephrine, Serotonin, & Platelet Function
    Dominique Musselman; Fiscal Year: 2005
    ..platelet autocrine "feed forward" pathways via: platelet serotonin (5HT) and 5HT2 receptors, platelet adenosine triphosphate (ATP) release, and urinary excretion of 11-dehydrothromboxane beta2: (1) under controlled basal conditions,..
  44. NPY Induced Regulation of Sympathetic Neurotransmission
    THOMAS WESTFALL; Fiscal Year: 2006
    Neuropeptide Y (NPY) is known to be co-localized, with norepinephrine (NE) and adenosine triphosphate (ATP) in vascular sympathetic neurons where it is thought to play a role as a co-transmitter/co-modulator...
  45. MUSCLE REFLEX CONTROL OF THE CIRCULATION
    Lawrence Sinoway; Fiscal Year: 2006
    ..The short-range goal of this proposal is to examine the role adenosine triphosphate (ATP) plays in evoking and modulating the pressor response to muscle contraction...
  46. Partial-Thickness Wound Healing via Topical ATP Delivery
    William Ehringer; Fiscal Year: 2005
    ..Ultimately the oxygen, and some of the nutrients, are used to produce adenosine triphosphate (ATP)...
  47. RADIAL AND LONGITUDINAL MICROVASCULAR COMMUNICATION
    Hans Dietrich; Fiscal Year: 2000
    ..The significance of NO in the propagation will be demonstrated by supplementing NO in eNOS deficient mouse arterioles. ..
  48. Interstitial Norepinephrine and Heart Failure
    Jianhua Li; Fiscal Year: 2007
    ..The first and second specific aims are to examine the mechanisms for the rise in interstitial NE (NEi) and adenosine triphosphate (ATPi) in exercising muscle...
  49. Effects of Stretch on IC and Normal Urothelia
    Toby Chai; Fiscal Year: 2005
    ..heparin binding epidermal growth factor-like growth factor (HB-EGF), antiproliferative activity (APF), and adenosine triphosphate (ATP), they propose to test these hypotheses: 1...
  50. Development of a Direct Cellular Energy Delivery System
    William Ehringer; Fiscal Year: 2003
    ..b>Adenosine triphosphate (ATP) is the immediate source of energy that is constantly synthesized and metabolized in the body to ..
  51. Development of a Direct Cellular Energy Delivery System
    William Ehringer; Fiscal Year: 2006
    b>Adenosine triphosphate (ATP) is the universal energy currency of the body and is made in large amounts by cells using substrate and oxygen...
  52. METABOLIC MAINTENANCE & GROWTH OF MYCOBACTERIUM LEPRAE
    Scott Franzblau; Fiscal Year: 1992
    ..bacillus using the following combination of sensitive metabolic assays: a) quantitation of intracellular adenosine triphosphate (ATP), b) incorporation of 14C-palmitate into PGL-1, c) measurement of the rate of 14CO2 released from 14C-..
  53. LX MULTI-NUCLEAR SPECTROSCOPY PACKAGE
    Russell Richardson; Fiscal Year: 2000
    ..capacity and state of the muscle as indicated by variables such as phosphocreatine, inorganic phosphate, adenosine triphosphate concentrations and pH...
  54. Physiology of ATP Release in Chronic Pain
    Yoshizo Matsuka; Fiscal Year: 2005
    ..However, the identity of the chemical mediator of cross-excitation is unknown. Adenosine triphosphate (ATP) is released within sensory ganglia following neuronal activation and was shown to activate receptors ..
  55. Linking functions of the FOF1 ATP Synthase
    Robert Nakamoto; Fiscal Year: 2005
    ..term goal of this project is to understand how the catalytic reaction of the hydrolysis or synthesis of adenosine triphosphate is coupled to the transport of protons across the membrane in the multi-subunit FOF 1 ATP synthase...
  56. TOPOLOGY OF THE ATP SYNTHASE
    Roderick Capaldi; Fiscal Year: 1990
    The universal fuel of cellular processes is adenosine triphosphate or ATP. In some bacteria, algae and plants, the energy stored in ATP comes from photosynthesis...
  57. ILEAL ABSORPTION OF BILE SALTS AND VITAMIN B-12
    ROBERT BEESLEY; Fiscal Year: 1980
    ..The effects of ions, ion gradients, adenosine triphosphate, temperature, pH, sulfhydryl transport of bile salts and vitamine B-12 will be ascertained...
  58. REDOX CHEMISTRY & BIOCHEMISTRY OF ORGANOSULFUR COMPOUNDS
    Richard Glass; Fiscal Year: 1992
    ..The energy produced in biological oxidations is used to drive the synthesis of adenosine triphosphate (ATP), which is the major energy source for heart muscle contraction and active ion transport...
  59. TC-99M ADENINE NUCLEOTIDE POLYPHOSPHATE IMAGING AGENTS
    John Babich; Fiscal Year: 2000
    ..Previously, we reported that 99mTc-Ap4A (diadenosine 5', 5", P1, P4-tetraphosphate and 99mTc-ATP (adenosine triphosphate) accumulate in tumors...
  60. HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLS
    Steven Deem; Fiscal Year: 2002
    ..In addition, the purines adenosine and adenosine triphosphate (ATP) may play a role in modulation of pulmonary vascular tone by RBCs...
  61. Proteomics to screen for a protein kinase that uses PEP
    GERALD CARLSON; Fiscal Year: 2006
    ..Phosphorylation is catalyzed by protein kinases, which for all known examples in eukaryotes use adenosine triphosphate (ATP) as the phosphoryl donor...
  62. RNA APTAMER COMPLEXES--STRUCTURES AND INTERACTIONS
    Dinshaw Patel; Fiscal Year: 1999
    ..Preliminary NMR data are presented on RNA aptamers complexed to flavin mononucleotide, adenosine triphosphate and the aminoglycoside antibiotic tobramycin that exhibit extremely well resolved spectra and are amenable ..
  63. THE NADH SHUTTLES AND METABOLIC ADAPTATION OF THE HEART
    Thomas Scholz; Fiscal Year: 2005
    ..activation of several fetal pathways that allow the heart to more efficiently utilize glucose and enhance adenosine triphosphate (ATP) production...
  64. VACCINIA VIRUS TRANSCRIPTION
    STEVEN BROYLES; Fiscal Year: 1999
    ..VETF is a unique promoter binding transcription activator that hydrolyzes adenosine triphosphate for an essential but undefined step in the initiation of RNA synthesis...