cyclic amp

Summary

Summary: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.

Top Publications

  1. pmc Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
    Russell A Miller
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 494:256-60. 2013
  2. pmc CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
    Judith Y Altarejos
    Sanford Burnham Medical Research Institute at Lake Nona, 6400 Sanger Road, Orlando, Florida 32827, USA
    Nat Rev Mol Cell Biol 12:141-51. 2011
  3. doi Epac: defining a new mechanism for cAMP action
    Martijn Gloerich
    Department of Physiological Chemistry, University Medical Center, Utrecht, The Netherlands
    Annu Rev Pharmacol Toxicol 50:355-75. 2010
  4. ncbi An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations
    Satoshi Sawai
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 433:323-6. 2005
  5. pmc Signal transduction cascades regulating fungal development and virulence
    K B Lengeler
    Departments of Genetics, Pharmacology and Cancer Biology, Microbiology, and Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Microbiol Mol Biol Rev 64:746-85. 2000
  6. pmc Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria
    P W Postma
    E C Slater Institute, University of Amsterdam, The Netherlands
    Microbiol Rev 57:543-94. 1993
  7. ncbi Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
    J de Rooij
    Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands
    Nature 396:474-7. 1998
  8. ncbi G protein signaling events are activated at the leading edge of chemotactic cells
    C A Parent
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 95:81-91. 1998
  9. ncbi Novel single chain cAMP sensors for receptor-induced signal propagation
    Viacheslav O Nikolaev
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacherstrasse 9, D 97078 Wurzburg, Germany
    J Biol Chem 279:37215-8. 2004
  10. pmc Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans
    K Shimizu
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, TX 77843 2132, USA
    Genetics 157:591-600. 2001

Research Grants

  1. GPCRs: Evolving Concepts and Drug Discovery
    Paul Insel; Fiscal Year: 2004
  2. CARDIOVASCULAR CELL GENE TRANSFER OF ADENYLYL CYCLASE
    Paul Insel; Fiscal Year: 2003
  3. Adrenergic and Purinergic Regulation of Target Cells
    Paul A Insel; Fiscal Year: 2010
  4. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
  5. Beta-Adrenergic Receptors of S49 Lymphoma Cells
    Paul Insel; Fiscal Year: 2005
  6. COX-2 Inhibitors, APC and Colon Cancer Prevention
    Kotha Subbaramaiah; Fiscal Year: 2009
  7. GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREE
    GIANFRANCO D ALPINI; Fiscal Year: 2010
  8. Central betal adrenergic receptors and behavior
    Han Ting Zhang; Fiscal Year: 2004
  9. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2008
  10. GENETIC ANALYSIS OF DOPAMINERGIC REWARD MECHANISMS
    Marc Caron; Fiscal Year: 2005

Detail Information

Publications280 found, 100 shown here

  1. pmc Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
    Russell A Miller
    Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 494:256-60. 2013
    ..leads to the accumulation of AMP and related nucleotides, which inhibit adenylate cyclase, reduce levels of cyclic AMP and protein kinase A (PKA) activity, abrogate phosphorylation of critical protein targets of PKA, and block ..
  2. pmc CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
    Judith Y Altarejos
    Sanford Burnham Medical Research Institute at Lake Nona, 6400 Sanger Road, Orlando, Florida 32827, USA
    Nat Rev Mol Cell Biol 12:141-51. 2011
    The cyclic AMP-responsive element-binding protein (CREB) is phosphorylated in response to a wide variety of signals, yet target gene transcription is only increased in a subset of cases...
  3. doi Epac: defining a new mechanism for cAMP action
    Martijn Gloerich
    Department of Physiological Chemistry, University Medical Center, Utrecht, The Netherlands
    Annu Rev Pharmacol Toxicol 50:355-75. 2010
    ..Advances in the understanding of the activation mechanism of Epac and its regulation by diverse anchoring mechanisms have helped to elucidate the means by which cAMP fulfills these functions via Epac...
  4. ncbi An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations
    Satoshi Sawai
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 433:323-6. 2005
    ..amoebae aggregate to form a multicellular structure by chemotaxis, moving towards propagating waves of cyclic AMP that are relayed from cell to cell...
  5. pmc Signal transduction cascades regulating fungal development and virulence
    K B Lengeler
    Departments of Genetics, Pharmacology and Cancer Biology, Microbiology, and Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Microbiol Mol Biol Rev 64:746-85. 2000
    ..two conserved signal transduction cascades: a mitogen-activated protein kinase cascade and a G-protein regulated cyclic AMP signaling pathway...
  6. pmc Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria
    P W Postma
    E C Slater Institute, University of Amsterdam, The Netherlands
    Microbiol Rev 57:543-94. 1993
    ..In gram-positive bacteria, it has been demonstrated that HPr can be phosphorylated by ATP on a serine residue and this modification may perform a regulatory function...
  7. ncbi Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
    J de Rooij
    Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, The Netherlands
    Nature 396:474-7. 1998
    ..At least three different second messengers, namely diacylglycerol, calcium and cyclic AMP, are able to activate Rap1 by promoting its release of the guanine nucleotide GDP and its binding to GTP...
  8. ncbi G protein signaling events are activated at the leading edge of chemotactic cells
    C A Parent
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 95:81-91. 1998
    ....
  9. ncbi Novel single chain cAMP sensors for receptor-induced signal propagation
    Viacheslav O Nikolaev
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacherstrasse 9, D 97078 Wurzburg, Germany
    J Biol Chem 279:37215-8. 2004
    ..The developed indicators could be ubiquitously applied to studying cAMP, its physiological role and spatio-temporal regulation...
  10. pmc Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans
    K Shimizu
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, TX 77843 2132, USA
    Genetics 157:591-600. 2001
    ..These data provide genetic evidence that the FlbA/FadA signaling pathway regulating ST production and morphological development is partially mediated through PkaA...
  11. ncbi Chemotaxis in the absence of PIP3 gradients
    Oliver Hoeller
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Biol 17:813-7. 2007
    ..A signaling pathway from receptor to cytoskeleton able to guide cells independently of polarized PIP3 and type-1 phosphoinositide 3-kinases must exist...
  12. pmc Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 206:535-48. 2009
    ..In human purified naive T cells, PGE2 acts via prostaglandin receptor EP2- and EP4-mediated signaling and cyclic AMP pathways to up-regulate IL-23 and IL-1 receptor expression...
  13. ncbi The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector
    Robert A Screaton
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 119:61-74. 2004
    ..Our results illustrate how a phosphatase/kinase module connects two signaling pathways in response to nutrient and hormonal cues...
  14. ncbi Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
    G A Gonzalez
    Clayton Foundation Laboratory for Peptide Biology, Salk Institute, La Jolla, California 92037
    Cell 59:675-80. 1989
    ....
  15. ncbi Structural basis for modulation and agonist specificity of HCN pacemaker channels
    William N Zagotta
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, Box 357290, University of Washington School of Medicine, Seattle, Washington 98195 7290, USA
    Nature 425:200-5. 2003
    ..On the basis of amino acid sequence similarity to HCN channels, the cyclic nucleotide-gated, and eag- and KAT1-related families of channels are probably related to HCN channels in structure and mechanism...
  16. pmc Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression
    Tobias Bopp
    Institute for Immunology, Johannes Gutenberg University, 55131 Mainz, Germany
    J Exp Med 204:1303-10. 2007
    ..Hence, naturally occurring T reg cells unexpectedly may control the immune regulatory network by a well-known mechanism based on the intercellular transport of cAMP via gap junctions...
  17. ncbi Heterotrimeric G protein signaling in filamentous fungi
    Liande Li
    Department of Plant Pathology and Microbiology, University of California, Riverside, California 92521, USA
    Annu Rev Microbiol 61:423-52. 2007
    ..This review provides a comparative analysis of G protein pathways in several filamentous species, with discussion of both unifying themes and important unique signaling paradigms...
  18. ncbi Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
    B Thorens
    Department of Pharmacology and Toxicology, University of Lausanne, Switzerland
    Diabetes 42:1678-82. 1993
    ..Because GLP-1 has been proposed as a potential agent for treatment of NIDDM, our present data will contribute to the characterization of the receptor binding site and the development of new agonists of this receptor...
  19. ncbi Epac proteins: multi-purpose cAMP targets
    Johannes L Bos
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Trends Biochem Sci 31:680-6. 2006
    ..In most of these processes, cAMP signaling through protein kinase A (PKA) is also involved, stressing the interconnectivity between Epac- and PKA-mediated signaling...
  20. doi HCN channels: structure, cellular regulation and physiological function
    C Wahl-Schott
    Center for Integrated Protein Science CIPSM and Zentrum für Pharmaforschung, Department Pharmazie, Pharmakologie für Naturwissenschaften, Ludwig Maximilians Universitat Munchen, Butenandtstr 5 13, 81377 Munchen, Germany
    Cell Mol Life Sci 66:470-94. 2009
    ..In this review we give an overview on structure, function and regulation of HCN channels. Particular emphasis will be laid on the complex roles of these channels for neuronal function and cardiac rhythmicity...
  21. pmc Reversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's-derived fibroblasts
    Latha Satish
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    BMC Musculoskelet Disord 12:113. 2011
    ..We propose that increasing the activation of the cyclic AMP (cAMP)/protein kinase A signaling pathway will inhibit transforming growth factor-beta1 (TGF-β1)-induced ECM ..
  22. pmc The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans
    Rebecca A Hall
    School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Eukaryot Cell 10:1034-42. 2011
    ..Hyphal development is regulated through modulation of the cyclic AMP (cAMP)/protein kinase A (PKA) signaling pathway, and it has been postulated that quorum-sensing molecules can ..
  23. pmc The onset of collective behavior in social amoebae
    Thomas Gregor
    Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153 8902, Japan
    Science 328:1021-5. 2010
    ..A quantitative analysis showed that stochastic pulsing of individual cells below the threshold concentration of extracellular cAMP plays a critical role in the onset of collective behavior...
  24. ncbi Transcriptional regulation by the phosphorylation-dependent factor CREB
    B Mayr
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 2:599-609. 2001
    The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory...
  25. ncbi Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
    J A Ballesteros
    Novasite Pharmaceuticals, Inc, San Diego, California 92121, USA
    J Biol Chem 276:29171-7. 2001
    ..49), Arg(3.50), and Glu(6.30) may constitute a common switch governing the activation of many rhodopsin-like G-protein-coupled receptors...
  26. ncbi Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma
    K Kitamura
    Department of First Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 192:553-60. 1993
    ..These data suggest that adrenomedullin is a new hormone participating in blood pressure control. Occurrence of adrenomedullin indicates the possible existence of a novel system for circulation control...
  27. pmc Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae
    S Colombo
    Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Flanders, Belgium
    EMBO J 17:3326-41. 1998
    ..Interaction of Ras2(val19) with adenylate cyclase apparently prevents its activation by both agonists...
  28. ncbi Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants
    V Asghari
    Department of Psychiatry, University of Toronto, Ontario, Canada
    J Neurochem 65:1157-65. 1995
    ..stimulation of the D4 receptors resulted in a concentration-dependent inhibition of the forskolin-stimulated cyclic AMP (cAMP) levels. The potency of dopamine to inhibit cAMP formation was about twofold reduced for D4...
  29. pmc Integrated allosteric model of voltage gating of HCN channels
    C Altomare
    Dipartimento di Fisiologia e Biochimica Generali, Via Celoria 26, , Via Celoria 16, 20133 Milano, Italy
    J Gen Physiol 117:519-32. 2001
    ..HCN voltage gating thus involves two processes: voltage sensor gating and allosteric opening/closing...
  30. pmc Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
    H E Parker
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Diabetologia 52:289-98. 2009
    ..The aim of this study was to generate transgenic mice with fluorescently labelled GIP-secreting K cells and to use these to investigate pathways by which K cells detect nutrients...
  31. ncbi beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor
    Sudha K Shenoy
    Howard Hughes Medical Institute at Duke University Medical Center, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 281:1261-73. 2006
    ..These findings demonstrate that the beta2AR can signal to ERK via a GRK5/6-beta-arrestin-dependent pathway, which is independent of G protein coupling...
  32. pmc Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide
    S Chen
    Department of Pharmacology, ColumbiaUniversity, New York, New York 10032, USA
    J Gen Physiol 117:491-504. 2001
    ..Finally, differences in Ih channel properties recorded in cell-free patches versus intact oocytes are shown to be due, in part, to modulation of Ih by basal levels of cAMP in intact cells...
  33. doi Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
    Oleg Dyachok
    Department of Medical Cell Biology, Uppsala University, Biomedical Centre, Box 571, SE 751 23 Uppsala, Sweden
    Cell Metab 8:26-37. 2008
    b>Cyclic AMP (cAMP) and Ca(2+) are key regulators of exocytosis in many cells, including insulin-secreting beta cells...
  34. ncbi A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
    Jorrit M Enserink
    Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584CG Utrecht, The Netherlands
    Nat Cell Biol 4:901-6. 2002
    ..Moreover, in cell lines in which cAMP activates ERK, inhibition of PKA and Ras, but not Rap1, abolished cAMP-mediated ERK activation. We conclude that cAMP-induced regulation of ERK and activation of Rap1 are independent processes...
  35. ncbi Transcriptional regulation by cyclic AMP
    M Montminy
    Department of Cell Biology, Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Annu Rev Biochem 66:807-22. 1997
    ..The second messenger cyclic AMP, for example, regulates a striking number of physiologic processes, including intermediary metabolism, cellular ..
  36. pmc Cyclic AMP-mediated cyst expansion
    Darren P Wallace
    Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA
    Biochim Biophys Acta 1812:1291-300. 2011
    ..This article is part of a Special Issue entitled: Polycystic Kidney Disease...
  37. pmc Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging
    Orie T Shafer
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Neuron 58:223-37. 2008
    ..Specifically, it experimentally confirms the longstanding hypothesis that PDF is a direct modulator of most neurons in the Drosophila clock network...
  38. pmc PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model
    Ming Du
    Department of Microbiology and Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 105:2064-9. 2008
    ....
  39. pmc Interplay of cellular cAMP levels, {sigma}S activity and oxidative stress resistance in Escherichia coli
    Evelyn Barth
    Department Chemie, Biotechnologie, Technische Universitat Munchen, Lichtenbergstrasse 4, 85747 Garching, Germany
    Microbiology 155:1680-9. 2009
    ..Our results demonstrate the close regulatory interplay between cellular cAMP levels, sigma(S) activity and oxidative stress resistance in E. coli...
  40. ncbi Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
    R Gauss
    Institut für Biologische Informationsverarbeitung, Forschungszentrum Julich, Germany
    Nature 393:583-7. 1998
    ..sperm through chemotactic peptides, which evoke complex changes in membrane voltage and in the concentrations of cyclic AMP, cyclic GMP and Ca2+ ions The intracellular signalling pathways and their cellular targets are largely unknown...
  41. pmc Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt
    T Kitamura
    Second Department of Internal Medicine, Kobe University School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Mol Cell Biol 19:6286-96. 1999
    ..phosphodiesterase (PDE) is an important regulator of the cellular concentrations of the second messengers cyclic AMP (cAMP) and cGMP...
  42. doi Interdependence of receptor activation and ligand binding in HCN2 pacemaker channels
    Jana Kusch
    Institut fur Physiologie II, Universitatsklinikum Jena, Jena, Germany
    Neuron 67:75-85. 2010
    ....
  43. pmc Expression cloning of a human corticotropin-releasing-factor receptor
    R Chen
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 90:8967-71. 1993
    ..We also describe an alternatively spliced form of the receptor which includes an insert of 29 amino acids in the first intracellular loop...
  44. pmc Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells
    Ronald Y Kwon
    Bone and Joint Rehabilitation R and D Center, Department of Veterans Affairs, Palo Alto, California, USA
    FASEB J 24:2859-68. 2010
    ..The signaling events identified provide important details of a novel early mechanosensing mechanism in bone and advances our understanding of how signal transduction occurs at the primary cilium...
  45. ncbi Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway
    Matthew C Wolfgang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 4:253-63. 2003
    ..Transcriptome analysis of mutants lacking the ability to synthesize cAMP or the cAMP binding protein Vfr implicated this pathway in the global regulation of host-directed virulence determinants, including the TTSS...
  46. ncbi Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    Edward J Filardo
    Department of Surgery, Rhode Island Hospital, and Brown University, Providence, Rhode Island 02903, USA
    Mol Endocrinol 16:70-84. 2002
    ....
  47. ncbi cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction
    Ning Zhong
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, California 9472, USA
    J Neurosci 25:208-14. 2005
    ..Epac also mediates the enhancement of tagged synapses. Thus, the cAMP-dependent enhancement of transmission is mediated by two separate pathways, neither of which involves protein kinase A...
  48. ncbi Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation
    Philip J S Stork
    Vollum Institute and the Dept of Cell and Developmental Biology, Oregon Health and Science University, Portland, OR 97201, USA
    Trends Cell Biol 12:258-66. 2002
    ..Emerging new data suggest that one of these mechanisms might involve the activation of the GTPase Rap1, which can activate or inhibit ERK signaling in a cell-specific manner...
  49. doi How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels
    Jana Kusch
    Institut fur Physiologie II, Universitatsklinikum Jena, Friedrich Schiller Universitat Jena, Jena, Germany
    Nat Chem Biol 8:162-9. 2012
    ..The channels are primarily activated by voltage but are receptors as well, binding the intracellular ligand cyclic AMP. The molecular mechanism of channel activation is still unknown...
  50. pmc In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia
    Marie Claude Guillemin
    CNRS UPR 9051, Laboratoire Associé au Comité de Paris de la Ligue contre le Cancer, affilié à l Université de ParisVII, France
    J Exp Med 196:1373-80. 2002
    ....
  51. pmc A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration
    Pascale G Charest
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0380, USA
    Dev Cell 18:737-49. 2010
    ..Thus, our study uncovered a molecular mechanism whereby RasC activity and the spatiotemporal activation of TORC2 are tightly controlled at the leading edge of chemotaxing cells...
  52. ncbi cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension
    Anne E Christensen
    Department of Anatomy and Cell Biology, University of Bergen, 5009 Bergen, Norway
    J Biol Chem 278:35394-402. 2003
    ..We therefore conclude that cAMP-induced neurite outgrowth is mediated by both Epac and cAPK...
  53. pmc Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
    Tadao Shibasaki
    Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, Hyogo 650 0017, Japan
    Proc Natl Acad Sci U S A 104:19333-8. 2007
    ..Taken together, these data indicate that Epac2/Rap1 signaling is essential in regulation of insulin granule dynamics by cAMP, most likely by controlling granule density near the plasma membrane...
  54. pmc Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion
    Yuko Nakagawa
    Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    PLoS ONE 4:e5106. 2009
    ..Sweet taste receptor is expressed in the taste buds and enteroendocrine cells acting as a sugar sensor. We investigated the expression and function of the sweet taste receptor in MIN6 cells and mouse islets...
  55. pmc Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
    X Fang
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:11960-5. 2000
    ....
  56. pmc Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit
    Qiang Ni
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Chem Biol 7:34-40. 2011
    ..Here, we show that protein kinase A (PKA), Ca(2+) and cyclic AMP (cAMP) oscillate in sync in insulin-secreting MIN6 beta cells, forming a highly integrated oscillatory circuit...
  57. ncbi cAMP signaling in Aspergillus fumigatus is involved in the regulation of the virulence gene pksP and in defense against killing by macrophages
    B Liebmann
    Institut fur Mikrobiologie, Universitat Hannover, Am Schneiderberg 50, 30167 Hannover, Germany
    Mol Genet Genomics 269:420-35. 2003
    ..Taken together, these findings suggest that cAMP triggers a system that protects A. fumigatus from the effects of immune effector cells of the host...
  58. pmc Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa
    Manuela Stierl
    Experimental Biophysics, Humboldt Universitat zu Berlin, Invalidenstrasse 42, D 10115 Berlin, Germany
    J Biol Chem 286:1181-8. 2011
    ..bPAC seems a perfect optogenetic tool for light modulation of cAMP in neuronal cells and tissues and for studying cAMP-dependent processes in live animals...
  59. pmc Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics
    Bernard Masri
    Departments of Cell Biology, Medicine and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:13656-61. 2008
    ..Thus, selective targeting of D2(L)R/beta-arrestin 2 interaction and related signaling pathways may provide new opportunities for antipsychotic development...
  60. ncbi DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
    J Kirsty Millar
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK
    Science 310:1187-91. 2005
    ..We propose a mechanistic model whereby DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP...
  61. ncbi Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor
    Y Chen
    Department of Pharmacology, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 289:625-8. 2000
    ..sAC is also expressed in other bicarbonate-responsive tissues, which suggests that bicarbonate regulation of cAMP signaling plays a fundamental role in many biological systems...
  62. ncbi Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
    Hilary A Overton
    OSI Prosidion, Windrush Court, Watlington Road, Oxford OX4 6LT, UK
    Cell Metab 3:167-75. 2006
    ..GPR119 therefore represents a novel and attractive potential target for the therapy of obesity and related metabolic disorders...
  63. ncbi Identification of the platelet ADP receptor targeted by antithrombotic drugs
    G Hollopeter
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
    Nature 409:202-7. 2001
    ..Cloning of the P2Y12 receptor should facilitate the development of better antiplatelet agents to treat cardiovascular diseases...
  64. pmc The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans
    Anne Lafon
    Unité Postulante Biologie et Pathogénicité Fongiques, INRA USC2019, Institut Pasteur, Paris, France
    Genetics 171:71-80. 2005
    ..Furthermore, GanB may function in sensing various carbon sources and subsequent activation of downstream signaling for germination...
  65. ncbi Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae
    J M Thevelein
    Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Kardinaal Mercierlaan 92, B 3001 Leuven Heverlee, Flanders, Belgium
    Mol Microbiol 33:904-18. 1999
    ..Cln3 appears to play a crucial role in the connection between the availability of certain nutrients and Cdc28 kinase activity, but it remains to be clarified which nutrient-controlled pathways control Cln3 levels...
  66. ncbi Cyclic nucleotide research -- still expanding after half a century
    Joseph A Beavo
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    Nat Rev Mol Cell Biol 3:710-8. 2002
    Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown...
  67. pmc Cyclic AMP: master regulator of innate immune cell function
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health, System, Ann Arbor, Michigan, USA
    Am J Respir Cell Mol Biol 39:127-32. 2008
    ..This article reviews the anatomy of the cAMP axis, the mechanisms by which it controls phagocyte immune function, microbial strategies to dysregulate it, and its clinical relevance...
  68. doi Store-operated cyclic AMP signalling mediated by STIM1
    Konstantinos Lefkimmiatis
    VA Boston Healthcare System and the Department of Surgery, Brigham and Women s Hospital and Harvard Medical School, West Roxbury, Massachusetts 02132, USA
    Nat Cell Biol 11:433-42. 2009
    ..We propose the existence of a pathway (store-operated cAMP signalling or SOcAMPS) in which the content of internal Ca(2+) stores is directly connected to cAMP signalling through a process that involves STIM1...
  69. doi Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins
    Guillaume Pidoux
    Biotechnology Centre of Oslo and Centre for Molecular Medicine, Nordic EMBL Partnership, University of Oslo, PO Box 1125, Blindern, N 0317 Oslo, Norway
    J Mol Endocrinol 44:271-84. 2010
    ....
  70. pmc Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells
    Kazuomi Noda
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    Mol Biol Cell 21:584-96. 2010
    ....
  71. doi Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase
    Nisheeth Agarwal
    Department of Medicine, Johns Hopkins School of Medicine, CRB2, Room 1 08, 1550 Orleans Street, Baltimore, Maryland 21231 1044, USA
    Nature 460:98-102. 2009
    ..Although infection by various mycobacterial species produces a cyclic AMP burst within macrophages that influences cell signalling, the underlying mechanism for the cAMP burst remains ..
  72. pmc A G protein-coupled receptor is essential for Schwann cells to initiate myelination
    Kelly R Monk
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 325:1402-5. 2009
    ..We propose that Gpr126 drives the differentiation of promyelinating Schwann cells by elevating cAMP levels, thereby triggering Oct6 expression and myelination...
  73. ncbi A family of hyperpolarization-activated mammalian cation channels
    A Ludwig
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Germany
    Nature 393:587-91. 1998
    ..Hormones and neurotransmitters that induce a rise in cyclic AMP levels increase Ih by a mechanism that is independent of protein phosphorylation, and which involves direct ..
  74. ncbi Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents
    Claire Lugnier
    CNRS UMR, 7034, Pharmacologie et Physicochimie des Interactions Moléculaires et Cellulaires, Faculte de Pharmacie, Universite Louis Pasteur de Strasbourg, 74 route du Rhin, BP 60024, 67401 Illkirch, France
    Pharmacol Ther 109:366-98. 2006
    ....
  75. ncbi Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes
    Wu Yin
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    J Biol Chem 278:43074-80. 2003
    ..These data indicate that there exists a novel pathway by which cAMP can lead to the activation of AMPK, and in adipocytes, this is required for maximal activation of lipolysis...
  76. ncbi Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans
    E Leberer
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Quebec H4P 2R2, Canada
    Mol Microbiol 42:673-87. 2001
    ..albicans cells through the induction of polarized morphogenesis. These findings elucidate a new medically relevant role for Ras in cellular morphogenesis and virulence in an important human infectious disease...
  77. pmc Differentiation-inducing factor-1 and -2 function also as modulators for Dictyostelium chemotaxis
    Hidekazu Kuwayama
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan
    PLoS ONE 4:e6658. 2009
    ....
  78. doi Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules
    Frans G M Russel
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 26, 6525 GA, Nijmegen, The Netherlands
    Trends Pharmacol Sci 29:200-7. 2008
    ..This review focuses on recent insights into the versatile transport function of MRP4 and its potential as a new therapeutic target to modulate various pathophysiological signalling processes...
  79. pmc Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
    D J Drucker
    Proc Natl Acad Sci U S A 84:3434-8. 1987
    ..These results indicate that glucagon-like peptide I may be a physiologic modulator of insulin gene expression...
  80. ncbi Glycogen synthase kinase 3beta is activated by cAMP and plays an active role in the regulation of melanogenesis
    Mehdi Khaled
    INSERM U385, Biologie et Physiopathologie de la Peau, IFR 50, 28 Avenue de Valombrose, 06107 Nice Cedex 2, France
    J Biol Chem 277:33690-7. 2002
    ....
  81. pmc The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization
    Kenneth C Hess
    Department of Pharmacology, Joan and Sanford Weill Medical College, Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Dev Cell 9:249-59. 2005
    ..This inhibitor revealed that capacitation is defined by separable events: induction of protein tyrosine phosphorylation and motility are sAC dependent while acrosomal exocytosis is not dependent on sAC...
  82. pmc Glucose- and hormone-induced cAMP oscillations in α- and β-cells within intact pancreatic islets
    Geng Tian
    Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden
    Diabetes 60:1535-43. 2011
    ..cAMP is a critical messenger for insulin and glucagon secretion from pancreatic β- and α-cells, respectively. Dispersed β-cells show cAMP oscillations, but the signaling kinetics in cells within intact islets of Langerhans is unknown...
  83. pmc A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability
    Marjetka Podobnik
    Laboratory for Biosynthesis and Biotransformation, National Institute of Chemistry of Slovenia, Hajdrihova 19, 1000 Ljubljana, Slovenia
    J Biol Chem 284:32846-57. 2009
    ..Rv0805 may therefore play a key role in the pathogenicity of mycobacteria, not only by hydrolyzing bacterial cAMP, but also by moonlighting as a protein that can alter cell wall functioning...
  84. pmc The myriad roles of cyclic AMP in microbial pathogens: from signal to sword
    Kathleen A McDonough
    Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, PO Box 22002, Albany, New York, New York 12201 2002, USA kathleen mcdonough wadsworth org
    Nat Rev Microbiol 10:27-38. 2012
    ..One such nucleotide is cyclic AMP, a universal second messenger that is used by diverse forms of life, including mammals, fungi, protozoa and ..
  85. pmc cAMP-regulated protein lysine acetylases in mycobacteria
    Subhalaxmi Nambi
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
    J Biol Chem 285:24313-23. 2010
    b>Cyclic AMP synthesized by Mycobacterium tuberculosis has been shown to play a role in pathogenesis...
  86. pmc p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
    Wenhong Cao
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:3057-67. 2004
    ..well established that catecholamine-stimulated thermogenesis in brown fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene...
  87. doi Mechanisms of protein kinase A anchoring
    Philipp Skroblin
    Leibniz Institute for Molecular Pharmacology, Berlin, Germany
    Int Rev Cell Mol Biol 283:235-330. 2010
    ..In addition, alternative PKA anchoring mechanisms employed by noncanonical AKAPs and PKA catalytic subunit-interacting proteins are illustrated...
  88. pmc The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus
    Burghard Liebmann
    Institut fur Mikrobiologie, Universitat Hannover, Schneiderberg 50, D 30167 Hannover, Germany
    Infect Immun 72:5193-203. 2004
    ..To determine the importance of the cyclic AMP (cAMP) signaling pathway for virulence, the pkaC1 gene encoding a protein kinase A (PKA) catalytic subunit was ..
  89. pmc Cyclic AMP negatively regulates prodigiosin production by Serratia marcescens
    Eric J Kalivoda
    Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, Pittsburgh, PA 15213, USA
    Res Microbiol 161:158-67. 2010
    ..Previous reports suggest that cyclic AMP (cAMP) is a positive regulator of prodigiosin production...
  90. ncbi A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose
    L Kraakman
    Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Institute of Botany and Microbiology
    Mol Microbiol 32:1002-12. 1999
    ..This appears to be the first example of a GPCR system activated by a nutrient in eukaryotic cells. Hence, a subfamily of GPCRs might be involved in nutrient sensing...
  91. pmc Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS)
    Sheng Li
    Department of Medicine and Biomedical Sciences Graduate program, University of California, San Diego, La Jolla, California 92093 0656, USA
    J Biol Chem 286:17889-97. 2011
    ....
  92. doi Adenylyl cyclase regulates heavy metal sensitivity, bikaverin production and plant tissue colonization in Fusarium proliferatum
    Gabor Kohut
    Agricultural Biotechnology Center, Mycology Group of the Hungarian Academy of Sciences, Institute of Plant Protection, Szent Istvan University, Godollo, Hungary
    J Basic Microbiol 50:59-71. 2010
    ..This finding provides further evidence of the role of the cAMP-PKA pathway in regulating bikaverin production...
  93. pmc Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling
    Yun Feng Li
    Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
    J Neurosci 31:172-83. 2011
    ..These novel findings will aid in the development of PDE4 subtype- or variant-selective inhibitors for treatment of disorders involving impaired cognition, including Alzheimer's disease...
  94. pmc 8-Chloro-cyclic AMP and protein kinase A I-selective cyclic AMP analogs inhibit cancer cell growth through different mechanisms
    Simona Lucchi
    Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, Milan, Italy
    PLoS ONE 6:e20785. 2011
    b>Cyclic AMP (cAMP) inhibits the proliferation of several tumor cells. We previously reported an antiproliferative effect of PKA I-selective cAMP analogs (8-PIP-cAMP and 8-HA-cAMP) on two human cancer cell lines of different origin...
  95. ncbi Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline
    Brian P Ramos
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 40:835-45. 2003
    ..These data demonstrate that PKA inhibition, rather than activation, is the appropriate strategy for restoring prefrontal cortical cognitive abilities in the elderly...
  96. ncbi Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells
    Eduard Stefan
    Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
    J Am Soc Nephrol 18:199-212. 2007
    ..Taken together, a novel, compartmentalized, and physiologically relevant cAMP-dependent signal transduction module on AQP2-bearing vesicles, comprising anchored PDE4D, AKAP18delta, and PKA, has been identified...
  97. ncbi Regulating gene transcription in response to cyclic AMP elevation
    William A Sands
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Cell Signal 20:460-6. 2008
    ....
  98. ncbi The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism
    H Zhong
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cell 89:413-24. 1997
    ..Therefore, this pathway represents a novel mechanism for the cAMP-independent activation of PKA and the regulation of NF-kappaB activity...
  99. pmc Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling
    Carmen W Dessauer
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Mol Pharmacol 76:935-41. 2009
    ..The ability of AKAPs to assemble intricate feedback loops to control spatiotemporal aspects of cAMP signaling adds yet another dimension to the classic cAMP pathway...
  100. ncbi Identification of the cpdA gene encoding cyclic 3',5'-adenosine monophosphate phosphodiesterase in Escherichia coli
    R Imamura
    Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto, Kumamoto 862, Japan
    J Biol Chem 271:25423-9. 1996
    ..Our results suggested that regulation of intracellular concentration of cAMP is dependent not only on synthesis of cAMP but also on hydrolysis of cAMP by cAMP phosphodiesterase...
  101. doi Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation
    Viacheslav O Nikolaev
    Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Science 327:1653-7. 2010
    ..Thus, the redistribution of beta(2)ARs in heart failure changes compartmentation of cAMP and might contribute to the failing myocardial phenotype...

Research Grants72

  1. GPCRs: Evolving Concepts and Drug Discovery
    Paul Insel; Fiscal Year: 2004
    ..Attendees will thus have the chance to learn and discuss new cutting edge topics regarding GPCRs. ..
  2. CARDIOVASCULAR CELL GENE TRANSFER OF ADENYLYL CYCLASE
    Paul Insel; Fiscal Year: 2003
    ..is designed to test hypotheses related to gene transfer of adenylyl cyclases to modulate agonist-specific cyclic AMP generation of cardiovascular cells...
  3. Adrenergic and Purinergic Regulation of Target Cells
    Paul A Insel; Fiscal Year: 2010
    ....
  4. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  5. Beta-Adrenergic Receptors of S49 Lymphoma Cells
    Paul Insel; Fiscal Year: 2005
    ..which to characterize the role of particular components in this pathway in which BAR increase cellular levels of cyclic AMP (cAMP), activate protein kinase A (PKA), and trigger events that ultimately lead to growth arrest and death of ..
  6. COX-2 Inhibitors, APC and Colon Cancer Prevention
    Kotha Subbaramaiah; Fiscal Year: 2009
    ..These studies will enhance our understanding of the mechanistic link between COX-2 and colorectal cancer and potentially assist us in optimizing the use of selective COX-2 inhibitors as therapy. ..
  7. GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREE
    GIANFRANCO D ALPINI; Fiscal Year: 2010
    ..It is our firm belief that the results of these studies will provide information that will not only allow us to better understand cholangiocyte pathobiology but will also lead to treatments for cholestatic liver diseases. ..
  8. Central betal adrenergic receptors and behavior
    Han Ting Zhang; Fiscal Year: 2004
    ..This will lead to the better understanding of pathophysiology and pharmacotherapy of depression. ..
  9. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2008
    ..abstract_text> ..
  10. GENETIC ANALYSIS OF DOPAMINERGIC REWARD MECHANISMS
    Marc Caron; Fiscal Year: 2005
    ..This should allow identification of genes involved in stable alterations of the CNS associated with chronic drug exposure. ..
  11. OPIOID AND ALCOHOL REGULATED IMMUNE FUNCTION
    DIPAK SARKAR; Fiscal Year: 2002
    ....
  12. Dopamine Receptors: Characterization and Regulation
    Marc Caron; Fiscal Year: 2007
    ..abstract_text> ..
  13. Preclin. model for prevention of NSCLC in former smokers
    HILDEGARD SCHULLER; Fiscal Year: 2006
    ....
  14. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  15. The Novel Role for Adenosine Receptor Agonists in Acquired Neonatal Tolerance
    Peter Ernst; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Antioxidant Defense System and Leydig Cell Aging
    Haolin Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Renin regulation by nitric oxide
    WILLIAM BEIERWALTES; Fiscal Year: 2007
    ..These studies should reveal the dual pathways by which NO can either inhibit or stimulate renin secretion. ..
  18. Mechanisms of Leptin Signaling in the Hypothalamus
    Abhiram Sahu; Fiscal Year: 2007
    ..PDE3B, PDE3A, PDE4, PKB, PI3K activity will be measured by enzyme assays. Cyclic AMP levels will be measured by RIA...
  19. Molecular determinants of ACTH receptor for ligand binding
    Yingkui Yang; Fiscal Year: 2006
    ..The information will serve to establish a foundation on which to build a comprehensive understanding of the signaling events that regulate ACTH mediated adrenal function in physiologic and diseased states. ..
  20. SWITCHING IN THE ORAL COMMENSAL CANDIDA GLABRATA
    David Soll; Fiscal Year: 2006
    ..abstract_text> ..
  21. Signal Transduction Mechanisms in Suicide Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..abstract_text> ..
  22. Functional characterization of FSHR alternatively spliced variants
    Maria Lalioti; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Epigenetic Regulation of Transcriptional Repression by Drugs of Abuse
    ANNE ELIZABETH WEST; Fiscal Year: 2010
    ..The identification of epigenetic mechanisms involved in regulation of gene expression by drugs of abuse may reveal new targets for therapies in treatment of drug addiction. ..
  24. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  25. The Role of Neuronal Integration in Working Memory
    Eric R Kandel; Fiscal Year: 2010
    ..How does HCN1 knockout affect the physiological properties of circuits involved in short-term memory both in the prefrontal cortex? 3) Does HCN1 influence the 'on-line'neural representation of information during working memory? ..
  26. mAKAP-orchestrated phosphorylation events: regulation of PDE4D3
    Kimberly L Dodge Kafka; Fiscal Year: 2010
    ..This study will further our understanding of the molecular mechanism of cardiac hypertrophy and help to identify novel targets for drug design to aid in the treatment of hypertrophy. ..
  27. ELECTROPHYSIOLOGY OF TASTE TRANSDUCTION
    Sue Kinnamon; Fiscal Year: 2009
    ....
  28. Ion transport and motility in larval mosquito stomach
    David F Moffett; Fiscal Year: 2010
    ..Analyses of peristalsis and its regulation with electrophysiological techniques and image analyses. The results of this project will provide information about specific targets for the development of mosquito control agents. ..
  29. Studies on the Eppin family of proteins on chromosome 20
    MICHAEL G O apos RAND; Fiscal Year: 2010
    ..This aim will test the hypothesis that anti-Eppin antibodies disrupt Eppin's modulation of PSA activity. ..
  30. Regulation of BDNF Expression by Calcium-stimulated Protein Kinases
    Hongbing Wang; Fiscal Year: 2010
    ....
  31. NICOTINE EFFECTS ON THE ADRENAL MEDULLA AND BRAIN
    ARNOLD TANK; Fiscal Year: 2009
    ..3) To test whether PCBP and the polyC-rich sequence to which it binds in the 3'UTR of TH mRNA participate in the stabilization of TH mRNA in response to the activation of signaling pathways that mediate the response to nicotine. ..
  32. Calmodulin-Activated Adenylyl Cyclase Toxins
    Wei Jen Tang; Fiscal Year: 2009
    Adenylyl cyclase is the enzyme that converts ATP to cyclic AMP (cAMP). cAMP is an intracellular second messenger that controls diverse physiological responses. Several human pathogens secrete highly active adenylyl cyclase toxins...
  33. Synergistic activation of PTGS2 and CXCL8 by Ni and microbial stimuli
    Kelly Brant; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Dissection of Ethanol Actions on Cholinergic Nerve Endings
    TIMOTHY SEARL; Fiscal Year: 2008
    ..Our preliminary data with botulinums toxins demonstrate that the synaptic vesicle protein synaptobrevin is an important target for the effects of ethanol. [unreadable] [unreadable] [unreadable] [unreadable]..
  35. Genetic Screening:Oncogene RAS-Based Inhibi*(RMI)
    Xiaodong Cheng; Fiscal Year: 2005
    ....
  36. Notch Signaling in Olfactory Progenitor Cell Fate
    TIMOTHY HENION; Fiscal Year: 2004
    ..The results obtained from these preliminary studies will provide important information on the mechanisms which regulate cell diversity in the olfactory system, and potentially other neurogenic tissues. ..
  37. Web-Based System for Research Protocol Submission
    Roberto Gomez; Fiscal Year: 2003
    ..We will try to reach small institutions by annoucements and demonstrations at local, regional and national meetings of the Society for Research Administration, International. ..
  38. P2U(P2Y2)-PURINOCEPTOR AND WATER TRANSPORT IN RAT KIDNEY
    BELLAMKONDA KISHORE; Fiscal Year: 2004
    ..Successful completion of these studies will lead to significant insights into the AVP-independent mechanisms of regulation of collecting duct water permeability. ..
  39. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  40. Gene transfer to the kidney using lentiviral vectors
    Frank Park; Fiscal Year: 2004
    ..abstract_text> ..
  41. ROLE OF UROCORTIN IN MAMMALIAN BRAIN AND PITUITARY
    AUDREY SEASHOLTZ; Fiscal Year: 2004
    ....
  42. Structure-Function Analysis of the D3 Dopamine Receptor
    Eldo Kuzhikandathil; Fiscal Year: 2003
    ..In doing so, ti study will make significant contributions toward ongoing efforts to define the role of D3 receptor neurological disorders such as schizophrenia. ..
  43. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003
    ..This may provide insight into the mechanisms leading to infertility (e.g., leuteinized unruptured follice syndrome) and support the developoment of PG synthesis inhibitors of PG synthesis inhibitors for use as contraceptives. ..
  44. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  45. ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINS
    Ira Goldberg; Fiscal Year: 2003
    ..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..
  46. OLFACTORY ELECTROPHYSIOLOGY IN CAENORHABDITIS ELEGANS
    STEVEN KLEENE; Fiscal Year: 2003
    ..The work proposed here will advance understanding of the molecular and cellular processes which subserve sensory function. ..
  47. TH GENE REGULATION IN HEALTHY AND LESIONED MIDBRAIN
    ARNOLD TANK; Fiscal Year: 2003
    ..These studies will shed light on the molecular mechanisms regulating the TH gene in the midbrain and may lead to new therapeutic strategies for the treatment of Parkinson's disease. ..
  48. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  49. 26th Annual Meeting of the North Am. Section of the ISHR
    Francisco Villarreal; Fiscal Year: 2004
    ..Partial support is requested to defray travel costs of invited participants, and to permit a registration fee low enough to encourage participation by junior faculty, postdoctoral fellows and students. ..
  50. Adenosine Mediated Modulation of Cardiac Fibrosis
    Francisco Villarreal; Fiscal Year: 2005
    ..We will assess for adenosine A2b receptor mediated induced inhibition of CF function and for the role of intracellular cAMP and/or cGMP in mediating ADO induced alterations in CF function. ..
  51. Switching and Candida Pathogenesis-A Molecular Analysis
    David Soll; Fiscal Year: 2005
    ..The first three aims have been formulated so that they provide several independent starting points for a reverse genetic approach for elucidating switch loci and the switching mechanism. ..
  52. Cardiovascular Stiffening in Aged Patients with CHF
    David Kass; Fiscal Year: 2005
    ..This could lead to new therapeutic approaches to this difficult clinical problem that affects a growing aged patient population. ..
  53. Gordon Research Conference on Calcium Signaling
    Colin Taylor; Fiscal Year: 2005
    ..abstract_text> ..
  54. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2005
    ..dependent regulation of natriuretic peptide receptors and to use this knowledge as a stepping stone towards the development of effective therapeutic agents for the treatment of cardiovascular diseases. ..
  55. Polycyclic Hydrocarbons and CYP1B1 in Breast Cancer
    Colin Jefcoate; Fiscal Year: 2005
    ..The correlation with CYP1B 1 expression and activity will provide insight into the relationship of the mouse model to human breast cancer. ..
  56. NNK, Beta-Adrenergic AA Release and Lung Cancer
    HILDEGARD SCHULLER; Fiscal Year: 2005
    ..2. To determine which products of the AA cascade are formed in untreated cells and in response to NNK, which of these products stimulate DNA synthesis, and what downstream effectors are activated by these products. ..
  57. Functional Genomics of Dictyostelium Development
    William Loomis; Fiscal Year: 2005
    ..Predictions derived from such networks will be tested when microarray analyses are extended to include further developmental mutants. ..
  58. Role of Stretch to Endothelial Pulse-Perfusion Response
    David Kass; Fiscal Year: 2005
    ..abstract_text> ..
  59. Sympathetic Modulation of the Immune System in Aging
    Denise Bellinger; Fiscal Year: 2005
    ..Specific Aim 3 explores possible mechanisms responsible for the age-related differences in sympathetic innervation of secondary lymphoid organs from these two rat strains. ..
  60. Cytokine Responses to H. pylori Infection, Immunization
    Peter Ernst; Fiscal Year: 2006
    ..pylori infection. 2). Identify T cell markers that are correlates of immunity. 3). Define mechanisms of host defense attributed to "protective" Th cells. ..
  61. Colonic Crypt HCO3 Secretion
    HENRY BINDER; Fiscal Year: 2006
    ..to perform microperfusion of isolated rat and mice colonic crypts (the site for secretory processes) in which cyclic AMP-dependent and Ca-dependent agonists induce HCO3 secretion...
  62. Regulation and role of CEACAM6 in the lung alveolus
    Philip L Ballard; Fiscal Year: 2011
    ..The studies of this project will examine expression and function of the protein in normal lung and its role in response to lung injury and infection. ..
  63. Education Program for Digestive Health Research
    Peter Ernst; Fiscal Year: 2008
    ..The trainees will be exposed to an enjoyable experience and long-term personal contacts that will be influential in encouraging them to pursue a career in biomedical research that will improve digestive health. ..
  64. The Role of Adenosine Receptors in Th Cell Development and Function
    Peter Ernst; Fiscal Year: 2008
    ..abstract_text> ..
  65. COLONIC CRYPT CELL FUNCTION
    HENRY BINDER; Fiscal Year: 2001
    ..We plan to establish the cellular model and the regulatory control of agonist-induced colonic bicarbonate secretion. These studies should define the cellular mechanisms of Na/C1/HCO/3 absorption and secretion in the colonic crypt. ..
  66. Modulation of intestinal inflammation by A2b receptor
    Vasantha Kolachala; Fiscal Year: 2007
    ..Thus, studies on the A2bR will lead not only to the understanding of intestinal inflammation but may lead to novel therapies for intestinal inflammatory disorders. ..
  67. Human Subjects Research Enhancements Programs
    William Rosner; Fiscal Year: 2002
    ..All such monthly reviews and quizzes will be archived for review. All of the above activities will be designed to be continued after the completion of the initial year of support. ..
  68. CYTOPROTECTIVE ROLE OF HEAT SHOCK PROTEINS IN IBD
    Eugene Chang; Fiscal Year: 2007
    ..unreadable] [unreadable]..