neoplasm rna

Summary

Summary: RNA present in neoplastic tissue.

Top Publications

  1. pmc The colorectal microRNAome
    Jordan M Cummins
    The Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 103:3687-92. 2006
  2. pmc Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    George Adrian Calin
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 99:15524-9. 2002
  3. ncbi Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism
    G J Peters
    Department of Medical Oncology, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Biochim Biophys Acta 1587:194-205. 2002
  4. ncbi Gene expression arrays in cancer research: methods and applications
    Ricardo R Brentani
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Crit Rev Oncol Hematol 54:95-105. 2005
  5. pmc Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid
    K Birkenkamp-Demtroder
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
    Gut 54:374-84. 2005
  6. pmc Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control
    A Seidel
    Institute of Hygiene, Faculty of Medicine, University of Leipzig, Liebigstrasse 27, D 04103 Leipzig, Germany
    Br J Cancer 94:1726-33. 2006
  7. pmc Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis
    Douglas R Hurst
    Department of Pathology, Comprehensive Cancer Center, and National Foundation for Cancer Research, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Cancer Res 69:1279-83. 2009
  8. ncbi Analysis of gene expression in stage I serous tumors identifies critical pathways altered in ovarian cancer
    Jeremy Chien
    Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gynecol Oncol 114:3-11. 2009
  9. ncbi AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon
    M J Zinda
    Cancer Research Division, Lilly Research Labs, Eli Lilly and Company, Lilly Corporate Center DC 0546, Indianapolis, IN 46285, USA
    Clin Cancer Res 7:2475-9. 2001
  10. ncbi BC200 RNA in invasive and preinvasive breast cancer
    Anna Iacoangeli
    Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Carcinogenesis 25:2125-33. 2004

Detail Information

Publications268 found, 100 shown here

  1. pmc The colorectal microRNAome
    Jordan M Cummins
    The Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 103:3687-92. 2006
    ..These studies suggest that the human genome contains many more miRNAs than currently identified and provide an approach for the large-scale experimental cloning of novel human miRNAs in human tissues...
  2. pmc Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    George Adrian Calin
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 99:15524-9. 2002
    ..Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority ( approximately 68%) of CLL cases...
  3. ncbi Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism
    G J Peters
    Department of Medical Oncology, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Biochim Biophys Acta 1587:194-205. 2002
    ..The clear retrospective relation between TS levels and response now forms the basis for a prospective study, in which TS levels are measured before treatment in order to determine the treatment protocol...
  4. ncbi Gene expression arrays in cancer research: methods and applications
    Ricardo R Brentani
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Crit Rev Oncol Hematol 54:95-105. 2005
    ..Hence, we shall also highlight some of the already available and promising applications of array technology on the day-to-day practice of oncology...
  5. pmc Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid
    K Birkenkamp-Demtroder
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
    Gut 54:374-84. 2005
    ..The aim of this study was to investigate differences in gene expression...
  6. pmc Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control
    A Seidel
    Institute of Hygiene, Faculty of Medicine, University of Leipzig, Liebigstrasse 27, D 04103 Leipzig, Germany
    Br J Cancer 94:1726-33. 2006
    ....
  7. pmc Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis
    Douglas R Hurst
    Department of Pathology, Comprehensive Cancer Center, and National Foundation for Cancer Research, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Cancer Res 69:1279-83. 2009
    ..These results further support the recent notion that modulating the levels of miR-146a or miR-146b could have a therapeutic potential to suppress breast cancer metastasis...
  8. ncbi Analysis of gene expression in stage I serous tumors identifies critical pathways altered in ovarian cancer
    Jeremy Chien
    Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gynecol Oncol 114:3-11. 2009
    ..The objective of this study was to characterize differentially expressed genes in high-grade stage I serous carcinoma of the ovary...
  9. ncbi AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon
    M J Zinda
    Cancer Research Division, Lilly Research Labs, Eli Lilly and Company, Lilly Corporate Center DC 0546, Indianapolis, IN 46285, USA
    Clin Cancer Res 7:2475-9. 2001
    ....
  10. ncbi BC200 RNA in invasive and preinvasive breast cancer
    Anna Iacoangeli
    Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    Carcinogenesis 25:2125-33. 2004
    ..The combined results demonstrate the potential of BC200 expression to serve as a molecular tool in the diagnosis and/or prognosis of breast cancer...
  11. ncbi MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
    Mark Bloomston
    Division of Surgical Oncology, James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, USA
    JAMA 297:1901-8. 2007
    ..While global microRNA (miRNA) expression patterns of many embryologic, physiologic, and oncogenic processes have been described, description of the role of miRNAs in ductal adenocarcinoma of the pancreas is lacking...
  12. pmc Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched
    Jose Miguel Garcia
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, E 28035 Madrid, Spain
    RNA 14:1424-32. 2008
    ....
  13. ncbi MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
    Scott A Armstrong
    Departments of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Genet 30:41-7. 2002
    ..Establishing that MLL is a unique entity is critical, as it mandates the examination of selectively expressed genes for urgently needed molecular targets...
  14. pmc Real-time expression profiling of microRNA precursors in human cancer cell lines
    Jinmai Jiang
    College of Pharmacy, Ohio State University, Columbus, OH, USA
    Nucleic Acids Res 33:5394-403. 2005
    ..Our study provides PCR primer sequences to all of the known human miRNA precursors as of December 2004 and provides a database of the miRNA precursor expression in many commonly used human cancer cell lines...
  15. ncbi MnSOD expression is less frequent in tumour cells of invasive breast carcinomas than in in situ carcinomas or non-neoplastic breast epithelial cells
    Y Soini
    Department of Pathology, University of Oulu and Oulu University Hospital, Oulu, Finland
    J Pathol 195:156-62. 2001
    ....
  16. ncbi mRNA markers of breast cancer nodal metastases: comparison between mammaglobin and carcinoembryonic antigen in 248 patients
    A Marchetti
    Department of Oncology and Neurosciences, University Gabriele D Annunzio, 66100 Chieti, Italy
    J Pathol 195:186-90. 2001
    ..The detection sensitivity of the mammaglobin RT-PCR is far superior to that of the CEA RT-PCR, allowing the diagnosis of occult metastases in nearly one-third of cases...
  17. pmc Gene expression patterns in human liver cancers
    Xin Chen
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA
    Mol Biol Cell 13:1929-39. 2002
    ..Some features of the gene expression patterns were associated with specific phenotypic and genotypic characteristics of the tumors, including growth rate, vascular invasion, and p53 overexpression...
  18. ncbi Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells
    Ala Eddin Al Moustafa
    Lady Davis Institute for Medical Research of the Sir Mortimer B Davis Jewish General Hospital, Department of Medicine, McGill Center for Translational Research in Cancer, 3755, Ch de la Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Oncogene 21:2634-40. 2002
    ..These findings provide a large body of information regarding gene expression profiles associated with head and neck carcinogenesis, and also represent a source of potential targets for HNSCC prevention and/or therapeutics...
  19. ncbi Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer
    P Gazzaniga
    Dipartimento di Medicina Sperimentale e Patologia, Universita degli Studi di Roma La Sapienza, Rome
    Ann Oncol 14:85-90. 2003
    ..No data are available concerning the significance of LIVIN in the progression of bladder tumors...
  20. pmc Molecular detection of micrometastatic breast cancer in histopathology-negative axillary lymph nodes correlates with traditional predictors of prognosis: an interim analysis of a prospective multi-institutional cohort study
    William E Gillanders
    Department of Surgery, Medical University of South Carolina, Charleston, SC, USA
    Ann Surg 239:828-37; discussion 837-40. 2004
    ..We sought to establish the clinical relevance of micrometastatic disease detected by reverse transcription polymerase chain reaction (RT-PCR) in axillary lymph nodes (ALN) of breast cancer patients...
  21. ncbi Cytokine expression and dendritic cell density in melanoma sentinel nodes
    Rafael Botella-Estrada
    Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain
    Melanoma Res 15:99-106. 2005
    ..However, the presence of certain immunosuppressive molecules, such as IL-10 and COX-2, could block their maturation and their ability to become efficient antigen presenters...
  22. pmc Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues
    Heidi J Peltier
    Asuragen, Inc, Austin, Texas 78744, USA
    RNA 14:844-52. 2008
    ..These findings constitute the first report describing the rigorous normalization of miRNA qRT-PCR data and have important implications for proper experimental design and accurate data interpretation...
  23. ncbi Prognostic relevance of a novel semiquantitative classification of Bcl2 immunohistochemical expression in human infiltrating ductal carcinomas of the breast
    D Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Italy
    Ann Oncol 18:1004-14. 2007
    ..In the present study, we evaluated the clinical relevance of a novel, semiquantitative classification of the Bcl2 immunostaining based on both the distribution and the intensity of the staining reaction...
  24. ncbi A simple method for RNA isolation from formalin-fixed and paraffin-embedded lymphatic tissues
    Tajana Körbler
    Laboratory of Cellular and Molecular Immunology, Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb, Croatia
    Exp Mol Pathol 74:336-40. 2003
    ..Although quantitative analysis of RNA isolated from archival tissue is probably not feasible due to the unpredictable degree of RNA isolation varying from sample to sample, we show here that screening analysis is possible and simple...
  25. ncbi Expression profiling of microdissected matched prostate cancer samples reveals CD166/MEMD and CD24 as new prognostic markers for patient survival
    Glen Kristiansen
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    J Pathol 205:359-76. 2005
    ..7, p = 0.006) in a Cox regression model, and was also superior to conventional markers. This combination of molecular markers thus appears to allow improved prediction of patient prognosis, but should be validated in larger studies...
  26. ncbi Differential gene expression identifies subgroups of ovarian carcinoma
    Amy P N Skubitz
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minn 55455, USA
    Transl Res 148:223-48. 2006
    ..In addition, the genes identified as over-expressed in each set of serous ovarian carcinoma compared with normal tissues may represent potential biomarkers and/or targets for therapy...
  27. ncbi Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas
    William Vermi
    Department of Pathology, University of Brescia, Brescia, 25124 Brescia, Italy
    J Pathol 200:255-68. 2003
    ..These results may explain why melanoma cells grow despite the presence of infiltrating immune cells...
  28. ncbi Expression of ADAM-9 mRNA and protein in human breast cancer
    Caroline O'Shea
    Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, Ireland
    Int J Cancer 105:754-61. 2003
    ..05) and correlated positively with HER-2/neu protein levels (r = 0.313, p = 0.016). This is the first report to describe expression of any ADAM in a large number of human carcinomas...
  29. ncbi Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma
    Youn Soo Lee
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Cancer Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 11:1059-64. 2005
    ..Such arrest may lead to autocrine stimulation, cell proliferation, and renal tumor development, similar to tumorigenesis of VHL disease-associated hemangioblastomas...
  30. ncbi Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer
    David Agudo
    Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avenida de Atenas s n, E 28922 Alcorcón, Madrid, Spain
    Int J Cancer 109:717-20. 2004
    ..Indeed, analysis of Nup107 (which is a limiting component of the nuclear pore complex) under the same conditions in the same tumors did not yield comparable results...
  31. ncbi Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach
    S Tozlu
    Centre Rene Huguenin, FNCLCC, St Cloud F 92210, France
    Endocr Relat Cancer 13:1109-20. 2006
    ..Some of the genes identified here could be useful for diagnosis or for predicting endocrine responsiveness, and could form the basis for novel therapeutic strategies...
  32. pmc A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma
    B Van den Eynde
    Ludwig Institute for Cancer Research, Brussels Branch, Belgium
    J Exp Med 182:689-98. 1995
    ..About 50% of melanoma patients carry on their tumor at least one of the presently defined antigens encoded by the MAGE, BAGE, and GAGE genes...
  33. ncbi Potential molecular marker for detecting transitional cell carcinoma
    Allen W Chiu
    Department of Surgery Division of Urology, Chi Mei Foundation Medical Center, Yung Kang City, Tainan, Taiwan
    Urology 60:181-5. 2002
    ....
  34. ncbi Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas
    J Reifenberger
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Virchows Arch 436:487-93. 2000
    ..Our findings corroborate that loss of heterozygosity on chromosome 10 is a frequent aberration in malignant melanomas and implicate PTEN as a tumour suppressor gene inactivated by somatic mutation in a fraction of these tumours...
  35. pmc Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1
    Mohd W Nasser
    Department of Molecular and Cellular Biochemistry and Pathology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:33394-405. 2008
    ..Thus, miR-1 has potential therapeutic application against lung cancers...
  36. pmc The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
    Yong Sun Lee
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Genes Dev 21:1025-30. 2007
    ....
  37. ncbi Identifying distinct classes of bladder carcinoma using microarrays
    Lars Dyrskjøt
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Nat Genet 33:90-6. 2003
    ..006). Furthermore, gene expression profiles characterizing each stage and subtype identified their biological properties, producing new potential targets for therapy...
  38. ncbi Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer
    U Lehmann
    Institute of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    J Pathol 214:17-24. 2008
    ..8). In conclusion, this study demonstrates that various microRNA genes are also affected by epigenetic inactivation due to aberrant hypermethylation and that this is an early and frequent event in breast cancer development...
  39. ncbi Changes in gene expression associated with response to neoadjuvant chemotherapy in breast cancer
    Juliane Hannemann
    Division of Experimental Therapy, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Clin Oncol 23:3331-42. 2005
    ..We investigated whether gene expression profiles of the primary tumor could be used to predict treatment response to either of those chemotherapy regimens...
  40. ncbi Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance
    A Stathopoulou
    Laboratory of Tumor Cell Biology and Department of Biostatistics, School of Medicine, University of Crete, Greece
    J Clin Oncol 20:3404-12. 2002
    ....
  41. pmc Quantitative gene expression analysis in microdissected archival formalin-fixed and paraffin-embedded tumor tissue
    K Specht
    Institute of Pathology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Am J Pathol 158:419-29. 2001
    ....
  42. ncbi Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance
    M Andrianifahanana
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 984525 Nebraska Medical Center, Omaha, NE 68198 4525, USA
    Clin Cancer Res 7:4033-40. 2001
    ..In a search for a unique and reliable marker(s) specific for pancreatic adenocarcinoma, we investigated the expression of different MUC genes in pancreatic tumors and tumor cell lines, in chronic pancreatitis, and in the normal pancreas...
  43. ncbi let-7 microRNA functions as a potential growth suppressor in human colon cancer cells
    Yukihiro Akao
    Department of Genetic Diagnosis, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Biol Pharm Bull 29:903-6. 2006
    ..These findings suggest the involvement of let-7 miRNA in the growth of colon cancer cells. Thus, miRNAs might provide a basis for novel RNA anti-cancer agents...
  44. pmc Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis
    T Tsurusaki
    Department of Urology, Nagasaki University School of Medicine, Japan
    Br J Cancer 80:309-13. 1999
    ..These results suggest that the expression of VEGF-C in prostatic carcinoma cells is implicated in the lymph node metastasis...
  45. ncbi Global gene expression changes during neoadjuvant chemotherapy for human breast cancer
    Thomas A Buchholz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer J 8:461-8. 2002
    ..The purpose of this study was to analyze global gene expression changes in serial tumor core biopsy specimens taken during neoadjuvant chemotherapy for primary breast cancer...
  46. ncbi Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas
    T Tsuji
    Department of Cell Biology, Okayama University Graduate School of Medicine and Dentistry, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 289:257-63. 2001
    ..We determined the REIC/Dkk-3 locus on chromosome 11p15, where loss of heterozygosity has frequently been observed in human tumors. These findings indicate that REIC/Dkk-3 may function as a tumor suppressor...
  47. ncbi Mammaglobin a in breast cancer: existence of multiple molecular forms
    Neil A O'Brien
    Department of Nuclear Medicine, St Vincent s University Hospital, Dublin, Ireland
    Int J Cancer 114:623-7. 2005
    ..As expression of MGA is almost breast specific, it is a promising marker for breast cancer. Its most immediate use is likely to be in detecting micrometastases from breast cancer...
  48. ncbi Characterization of sarcomas by means of gene expression
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Lab Clin Med 144:78-91. 2004
    ..In addition, distinct clusters were observed that contained only MFH and NOS samples. We conclude that gene-expression patterns may be useful in helping further classify subtypes of sarcomas...
  49. ncbi Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine endometrial cancers
    W S Sun
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan
    Ann Oncol 14:898-906. 2003
    ..The aim of the present study was to test for the presence of Gas6 and its receptors Axl and Sky, related to specific growth in uterine endometrial cancers, and to evaluate their plausible growth potential and mechanism...
  50. pmc Molecular diagnosis of clear cell sarcoma: detection of EWS-ATF1 and MITF-M transcripts and histopathological and ultrastructural analysis of 12 cases
    Cristina R Antonescu
    Department of Patholog, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Mol Diagn 4:44-52. 2002
    ..These data confirm that EWS-ATF1 detection can be used as a highly sensitive diagnostic test for CCS and that CCS expresses the melanocyte-specific form of the MITF transcript, further supporting its genuine melanocytic differentiation...
  51. ncbi Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses
    Matthew Ellis
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20007, USA
    Clin Cancer Res 8:1155-66. 2002
    ..We wished to develop optimal tissue acquisition, processing, and analysis procedures for exploring the gene expression profiles of breast core needle biopsies representing cancer and noncancer tissues...
  52. pmc Measurement of gene expression in archival paraffin-embedded tissues: development and performance of a 92-gene reverse transcriptase-polymerase chain reaction assay
    Maureen Cronin
    Genomic Health Incorporated, Redwood City, California 94063, USA
    Am J Pathol 164:35-42. 2004
    ..These findings support the development of RT-PCR analysis of FPE tissue RNA as a platform for multianalyte clinical diagnostic tests...
  53. ncbi Evaluation and optimization of procedures for target labeling and hybridization of cDNA microarrays
    Jindan Yu
    Departments of Ophthalmology and Visual Sciences, Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
    Mol Vis 8:130-7. 2002
    ..Standardized protocols that consistently produce low background and high intensity hybridization with small amounts of starting RNA are needed to extract differentially expressed genes from a pool of thousands of unaltered genes...
  54. pmc Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer
    Anthony R Dallosso
    CLIC Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    RNA 13:2287-99. 2007
    ..These results show that WT1 encodes conserved antisense RNAs that may have an important regulatory role in WT1 expression via RNA:RNA interactions, and which can become deregulated by a variety of mechanisms in cancer...
  55. ncbi Characterization of a zinc-finger protein and its association with apoptosis in prostate cancer cells
    G T Chang
    Department of Endocrinology and Reproduction, Josephine Nefkens Institute, Erasmus University Rotterdam, The Netherlands
    J Natl Cancer Inst 92:1414-21. 2000
    ..Physiologic levels (0.1 nM:) of androgens repress expression of GC79 messenger RNA (mRNA) in LNCaP-FGC cells. To determine the role of GC79, we cloned its complementary DNA (cDNA) and functionally characterized its product...
  56. ncbi Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
    P M O'Connor
    Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 57:4285-300. 1997
    ..This information also allows for the large-scale analysis of the more than 60,000 compounds tested against these lines for novel agents that might exploit defective p53 function as a means of preferential toxicity...
  57. ncbi Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors
    F K Rae
    Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Mol Carcinog 32:44-53. 2001
    ..The upregulation of this gene in several solid tumors indicated that it may play an important role in tumorigenesis...
  58. ncbi Global gene expression profiling of circulating tumor cells
    Denis A Smirnov
    Immunicon Corporation, Huntingdon Valley, Pennsylvania 19006, USA
    Cancer Res 65:4993-7. 2005
    ..Genes such as AGR2, S100A14, S100A16, FABP1, and others were found useful for detection of CTCs in peripheral blood of advanced cancer patients...
  59. ncbi A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    P van der Bruggen
    Ludwig Institute for Cancer Research, Brussels, Belgium
    Science 254:1643-7. 1991
    ..Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample...
  60. ncbi Splice variants as cancer biomarkers
    Brigitta M N Brinkman
    ExonHit Therapeutics, Paris, France
    Clin Biochem 37:584-94. 2004
    ..This review discusses the basic mechanism of alternative splicing, alternative splicing in cancer-associated genes, tools to identify splice variants, and the development of clinical tests based on alternatively spliced biomarkers...
  61. ncbi Identification of gene signatures for invasive colorectal tumor cells
    Anja H Wiese
    Institut für allgemeine Pathologie und pathologische Anatomie, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Cancer Detect Prev 31:282-95. 2007
    ..Gene signatures of sporadic colorectal carcinoma tissues and microdissected colorectal tumor cells were analyzed to identify stromal and tumor cell-specific markers, respectively...
  62. ncbi Salivary transcriptome diagnostics for oral cancer detection
    Yang Li
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California, USA
    Clin Cancer Res 10:8442-50. 2004
    ..The purpose of this study is to evaluate the diagnostic value of this new approach by using oral squamous cell carcinoma (OSCC) as the proof-of-principle disease...
  63. ncbi EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival
    Zhenhe Suo
    Department of Pathology, The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Oslo, Norway
    J Pathol 196:17-25. 2002
    ..However, c-erbB-4 antagonizes the c-erbB-2 effect on clinical course in breast carcinomas. To achieve best results with immunotherapy against the c-erbB-2 receptor, clarifying the status of c-erbB-4 expression may be of significance...
  64. ncbi Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas
    Amy L McDoniels-Silvers
    Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Clin Cancer Res 8:1127-38. 2002
    ....
  65. ncbi DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer
    Daphne Hessels
    Department of Experimental Urology, Nijmegen Center for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 44:8-15; discussion 15-6. 2003
    ..DD3(PCA3) is the most prostate cancer-specific gene described to date. To assess the clinical utility of DD3(PCA3) a time-resolved fluorescence-based, quantitative RT-PCR analysis for DD3(PCA3) was developed...
  66. pmc Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster
    Michael Dews
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 38:1060-5. 2006
    ..Notably, miR-17-92-transduced cells formed larger, better-perfused tumors. These findings establish a role for microRNAs in non-cell-autonomous Myc-induced tumor phenotypes...
  67. pmc CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature
    Zhenhua Miao
    ChemoCentryx, Inc, Mountain View, CA 94043, USA
    Proc Natl Acad Sci U S A 104:15735-40. 2007
    ..Taken together, these data suggest that CXCR7 has key functions in promoting tumor development and progression...
  68. pmc Differential expression of the eukaryotic release factor 3 (eRF3/GSPT1) according to gastric cancer histological types
    J Malta-Vacas
    Escola Superior de Tecnologia da Saúde de Lisboa, 1990 096 Lisboa, Portugal
    J Clin Pathol 58:621-5. 2005
    ..There are now several lines of evidence to suggest that protein synthesis and translation factors are involved in the regulation of cell proliferation and cancer development...
  69. ncbi Differential expression of alternatively spliced mRNA forms of the insulin-like growth factor 1 receptor in human neuroendocrine tumors
    Lorenza Vitale
    Dipartimento di Istologia, Embriologia e Biologia Applicata, Universita di Bologna, I 40126 Bologna, Italy
    Oncol Rep 15:1249-56. 2006
    ..This study highlights the relevance of IGF1R mRNA expression in neuroendocrine tumor cells, and the constant presence of 'subtle' alternative splicing for the IGF1R locus...
  70. ncbi MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Gifu 504 0838, Japan
    Oncol Rep 16:845-50. 2006
    ..These findings indicate that the miRNAs 143 and 145 could become good tumor markers and provide an important clue in the study of the mechanism of oncogenesis involving miRNAs...
  71. ncbi Detection of epithelial messenger RNA in the plasma of breast cancer patients is associated with poor prognosis tumor characteristics
    J M Silva
    Department of Medical Oncology, Clinica Puerta de Hierro, E-28035 Madrid, Spain
    Clin Cancer Res 7:2821-5. 2001
    ..CONCLUSIONS: We conclude that epithelial tumor RNA is detectable in plasma from breast cancer patients and that this finding is associated with a probable poor prognosis and circulating tumor cells...
  72. ncbi The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours
    Jenita Rauta
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Breast Cancer Res Treat 95:257-63. 2006
    ..Taken together, our findings substantiate an important role for PPM1D in breast cancer...
  73. ncbi PRAME, a gene encoding an antigen recognized on a human melanoma by cytolytic T cells, is expressed in acute leukaemia cells
    N van Baren
    Cellular Genetics Unit, Universite Catholique de Louvain, Brussels, Belgium
    Br J Haematol 102:1376-9. 1998
    ..Approximately 25% of the acute leukaemia samples were positive. Remarkably, all acute myeloblastic leukaemias that carried the chromosomal translocation t(8;21), which fuses the genes AML1 and ETO, expressed PRAME at a high level...
  74. ncbi Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling
    M Soulez
    Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
    J Mol Endocrinol 27:259-74. 2001
    ..Further analysis of this set of markers will provide alternative approaches to the investigation of the mitogenicity of oestrogens in breast cancer cells...
  75. ncbi Visualizing chromosomes as transcriptome correlation maps: evidence of chromosomal domains containing co-expressed genes--a study of 130 invasive ductal breast carcinomas
    Fabien Reyal
    Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Paris, France
    Cancer Res 65:1376-83. 2005
    ..Transcription correlation maps are a new way of visualizing transcriptome data. They will help to identify new genes involved in tumor progression and new mechanisms of gene regulation in tumors...
  76. ncbi Frequent occurrence of uniparental disomy in colorectal cancer
    Claus Lindbjerg Andersen
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby DK 8200, Aarhus N, Denmark
    Carcinogenesis 28:38-48. 2007
    ..In conclusion, we demonstrate that uniparental disomy is frequent in CRC, and identify genomic alterations associated with TP53 inactivation and lymph node status...
  77. ncbi Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays
    Anirban Maitra
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Clin Cancer Res 9:5988-95. 2003
    ..Global expression microarrays can document abnormal pathways that impact on tumorigenesis and disease progression...
  78. ncbi Real-time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the lightcycler system
    Aliki Stathopoulou
    Laboratory of Analytical Chemistry, University of Athens, Athens, Greece
    Clin Cancer Res 9:5145-51. 2003
    ....
  79. ncbi Comparative proteomic analysis of esophageal squamous cell carcinoma
    Yijun Qi
    Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou, China
    Proteomics 5:2960-71. 2005
    ..These data may suggest that these proteins contribute to the multistage process of carcinogenesis, tumor progression, and invasiveness of ESCC...
  80. ncbi Trastuzumab administration can effectively target chemotherapy-resistant cytokeratin-19 messenger RNA-positive tumor cells in the peripheral blood and bone marrow of patients with breast cancer
    Vassiliki Bozionellou
    Department of Medical Oncology, University General Hospital of Heraklion, Crete, Greece
    Clin Cancer Res 10:8185-94. 2004
    ..Since a high proportion of these cells express the HER-2 receptor, we evaluated the effectiveness of the anti-HER-2 antibody trastuzumab (Herceptin) administration to eliminate them...
  81. ncbi Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation
    Zhiqiang Zou
    Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Rockville, Maryland 20852, USA
    Clin Cancer Res 8:1172-7. 2002
    ..The objective of this study is to investigate Maspin expression in prostate tumor specimens and explore the mechanisms of hormonal regulation of Maspin expression in prostate tumors...
  82. ncbi Overexpression of human Dickkopf-1, an antagonist of wingless/WNT signaling, in human hepatoblastomas and Wilms' tumors
    Oliver Wirths
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Lab Invest 83:429-34. 2003
    ..The overexpression of the inhibitor Dkk-1 may therefore be related to uncontrolled wingless/WNT signaling and may represent a negative feedback mechanism. hDkk-1 expression represents a novel marker for HBs and Wilms' tumors...
  83. pmc Specific detection of cytokeratin 20-positive cells in blood of colorectal and breast cancer patients by a high sensitivity real-time reverse transcriptase-polymerase chain reaction method
    Giuliana Giribaldi
    Universita di Torino, Dipartimento di Genetica, Biologia e Biochimica, Via Santena 5 bis, 10126 Torino, Italy
    J Mol Diagn 8:105-12. 2006
    ..026) but not colorectal cancer patients (P = 0.361). Negativity of all 150 healthy controls examined confers diagnostic potential to the method...
  84. ncbi Clinical evaluation of a new molecular method for detection of micrometastases in head and neck squamous cell carcinoma
    Carol G Shores
    Department of Otolaryngology Head and Neck Surgery, Neurosciences Hospital, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Arch Otolaryngol Head Neck Surg 130:937-42. 2004
    ..To better detect occult cervical metastases...
  85. ncbi Tumor suppressor PTEN is mutated in canine osteosarcoma cell lines and tumors
    R A Levine
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Pathol 39:372-8. 2002
    ..These results indicate that PTEN is mutated or downregulated in a high percentage of canine OS cell lines and tumors and likely plays an important role in the pathogenesis of the disease...
  86. ncbi MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets
    Raffaele Baffa
    Department of Urology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
    J Pathol 219:214-21. 2009
    ..Our results suggest that specific miRNAs may be directly involved in cancer metastasis and that they may represent a novel diagnostic tool in the characterization of metastatic cancer gene targets...
  87. ncbi Small is beautiful: microRNAs and breast cancer-where are we now?
    E T Verghese
    Leeds Teaching Hospital NHS Trust, UK
    J Pathol 215:214-21. 2008
    ..Here we present an overview of our current understanding of miRNA in breast cancer...
  88. pmc Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung
    Julien D F Licchesi
    Cancer Biology Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Carcinogenesis 29:895-904. 2008
    ....
  89. pmc MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer
    Jian Jun Zhao
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 283:31079-86. 2008
    ....
  90. pmc Evaluation of the similarity of gene expression data estimated with SAGE and Affymetrix GeneChips
    Fred van Ruissen
    Department of Neurogenetics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    BMC Genomics 6:91. 2005
    ..This study evaluates these overall measures and introduces the between-ratio difference as a concordance measure pergene...
  91. ncbi MicroRNAs and hematopoietic differentiation
    A Fatica
    Institute Pasteur Cenci Bolognetti, Department of Genetics and Molecular Biology and I B P M, University of Rome La Sapienza, Rome, Italy
    Cold Spring Harb Symp Quant Biol 71:205-10. 2006
    ..An interesting interplay between miRNAs and lineage-specific transcriptional factors has been found, and this can help us to understand how terminal differentiation is accomplished...
  92. pmc A robust method for the amplification of RNA in the sense orientation
    Nicholas F Marko
    The George Washington University Medical Center, USA
    BMC Genomics 6:27. 2005
    ..Alternatives lack extensive validation and are often confounded by problems with bias or yield attributable to their greater biological and technical complexity...
  93. ncbi Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Cancer Res 67:6092-9. 2007
    ..These results indicate that cyclin G1 is a target of miR-122a and expand our knowledge of the molecular alterations involved in HCC pathogenesis and of the role of miRNAs in human cancer...
  94. ncbi Reliable gene expression measurements from degraded RNA by quantitative real-time PCR depend on short amplicons and a proper normalization
    Janine Antonov
    Department of Clinical Research, University of Bern, Bern, Switzerland
    Lab Invest 85:1040-50. 2005
    ..We demonstrate that the relative abundance of gene expression can be based on FFPE material even when the amount of RNA in the sample and the extent of fragmentation are not known...
  95. ncbi Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma
    Christine H Chung
    Division of Hematology Oncology, Department of Medicine, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
    Cancer Res 66:8210-8. 2006
    ..The 75-gene list can be used as a prognostic biomarker of recurrence, and our data suggest that the molecular determinants of EMT and NF-kappaB activation can be targeted as the novel therapy in the identified high-risk patients...
  96. pmc Genome-wide estimation of transcript concentrations from spotted cDNA microarray data
    Arnoldo Frigessi
    Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Norway
    Nucleic Acids Res 33:e143. 2005
    ..It can be applied broadly, facilitating the construction of the transcriptome, continuously updating it by integrating future data...
  97. ncbi Evaluation of expression based markers for the detection of breast cancer cells
    Nicholas M Brown
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Breast Cancer Res Treat 97:41-7. 2006
    ..These two novel markers were compared with two other candidate markers, Mammaglobin and Cytokeratin 19 (CK19)...
  98. ncbi Identification of a gene signature for rapid screening of oral squamous cell carcinoma
    Amy F Ziober
    Department of Otorhinolaryngology Head and Neck Surgery, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 12:5960-71. 2006
    ..e., practitioner's or dentist's office) by minimally trained personnel...
  99. ncbi Quantitative expression profiling of highly degraded RNA from formalin-fixed, paraffin-embedded breast tumor biopsies by oligonucleotide microarrays
    Maria Ravo
    Dipartimento di Patologia generale and Centro Grandi Apparecchiature, Seconda Universita degli Studi di Napoli, Napoli, Italy
    Lab Invest 88:430-40. 2008
    ..The method proved itself sensitive, reproducible and accurate, when compared to results obtained by microarray analysis of RNA extracted from snap-frozen tissue of the same tumor...
  100. ncbi Identification of gene expression profiles that segregate patients with childhood leukemia
    Philip J Moos
    Center for Children at the Huntsman Cancer Institute and Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Clin Cancer Res 8:3118-30. 2002
    ....
  101. ncbi Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma
    Jie Zhang
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, 734 8551, Hiroshima, Japan
    Virchows Arch 442:563-8. 2003
    ..Our results support an idea that increased TSP-1 expression may be associated with an angiogenic phenotype in gastric carcinoma and suggest that TSP-1 may play diverse roles in each organ...

Research Grants74

  1. Real-time PCR expression profiling of microRNA
    Thomas Schmittgen; Fiscal Year: 2006
    ..The unparallel sensitivity and specificity of real-time PCR as applied to this new and exciting class of regulatory RNAs should propel the field into new directions not only in cancer but in other areas of human health. ..
  2. Micro RNA Expression and Cancer
    Thomas Schmittgen; Fiscal Year: 2005
    ..Assays developed with this research may help to identify the function of a new class of genes in humans. ..
  3. Retrospective validation of putative breast cancer predictive molecular markers
    Indira Poola; Fiscal Year: 2008
    ..Detection at the precancerous stage and treatment could lead to fewer incidences of breast cancer and deaths from it. [unreadable] [unreadable] [unreadable]..
  4. Diagnosis and prognosis of lung cancer using gene ratios
    GAVIN GORDON; Fiscal Year: 2004
    ..Specific Aim 4. To develop software for the expression ratio test and to design a form summarizing the results of the diagnostic test kit to clinicians and health care personnel. ..
  5. Tumor drug delivery systems based on polymalic acid
    Julia Y Ljubimova; Fiscal Year: 2010
    ..Aim 4. Evaluation of the effects of lead compounds on animal survival, tumor size, vascularity, apoptosis, and expression of their molecular targets, EGFR and laminin-8, in xenotransplanted human tumors. ..
  6. Cell Sorting and Molecular Analysis for Minimal Disease Detection
    Barbara Zehentner; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  7. Hedgehog signaling in pancreatic neoplasia
    Anirban Maitra; Fiscal Year: 2006
    ..Specifically, it will be determined whether Hh misexpression can generate a phenotype of multistep progression of pancreatic cancer that resembles the cognate human condition. [unreadable] [unreadable]..
  8. Use of RNAi to investigate cullin-5 function in breast cancer
    Michael Fay; Fiscal Year: 2006
    ..A better understanding of cancer-related genes, such as Cul5, is expected to lead to better therapies for patients. [unreadable] [unreadable] [unreadable] [unreadable]..
  9. Prognostic markers for ovarian cancer
    Samuel Mok; Fiscal Year: 2006
    ..abstract_text> ..
  10. A Phase 1 Study of CCI-779 in Combination with Imatnib *
    RANDALL HOLCOMBE; Fiscal Year: 2006
    ..Since deregulated kinase activity is known to contribute to a wide range of malignancies, these studies will have applicability to cancer therapy in general. [unreadable] [unreadable]..
  11. 5th International Symposium on Hormonal Carcinogenesis
    Jonathan Li; Fiscal Year: 2006
    ..Area 4: Hormone Dependency and Independency. e) In prostate, breast and uterine cancer, Session 6. As in the past, a book will be published of the presentations. [unreadable] [unreadable] [unreadable] [unreadable]..
  12. Examination of FLT3 Mutations in Acute Myeloid Leukemia
    Derek Stirewalt; Fiscal Year: 2006
    ..Together, the research proposal and educational program provide Dc Stirewalt with the skills to become an independent clinical investigator. ..
  13. Pharmacogenomics of Neoadjuvant Gemcitabine-Pemetrexed *
    Gerold Bepler; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  14. Integrin Activation in Breast Cancer Metastasis
    Brunhilde Felding Habermann; Fiscal Year: 2006
    ....
  15. Novel Molecular Profiling of Prostate Cancer Signatures
    Shao Yao Ying; Fiscal Year: 2006
    ..These results may pave the way for a precise gene-chip diagnosis of stage-specific markers of human prostate cancer. ..
  16. Novel Method for Isolating Actively Translated mRNAs
    Jingfang Ju; Fiscal Year: 2007
    ..3.) Identify potential translationally regulated genes that are responsible for determining chemosensitivity during 5- fluorouracial (5-FU) treatment from human colon cancer samples. [unreadable] [unreadable] [unreadable]..
  17. Genomic Instability and Etiology of Estrogen Oncogenesis
    Jonathan Li; Fiscal Year: 2007
    ..abstract_text> ..
  18. Preoperative chemotherapy for breast cancer
    Lajos Pusztai; Fiscal Year: 2007
    ..We expect that our work will lead to the development of microarray-based clinical tests to personalize chemotherapy selection for an individual with newly diagnosed breast cancer. ..
  19. Neurochemistry/physiology of proopiomelancortin neurons
    Malcolm Low; Fiscal Year: 2008
    ..The techniques involved are aggregation chimera formation and Cre recombinase mediated reactivation of POMC expression from a neuron-specific and reversibly silenced POMC allele. ..
  20. AGING AND ENDOTHELIAL CELL FUNCTION
    May Reed; Fiscal Year: 2009
    ..The elucidation of mechanisms that regulate MMP activity in aged cells and tissues will assist the development of therapies to improve wound repair and revascularization of ischemic organs. ..
  21. BI-1, A Regulator of ER-Stress Pathways Linked to Apoptosis
    John Reed; Fiscal Year: 2009
    ..Altogether, these studies will improve understanding of how damage to the ER is linked to apoptosis, and will potentially reveal strategies for neuronal preservation in stroke and neurodegenerative diseases. ..
  22. High Throughput Screening Assays for NOD1 and NOD2 Inhibitors
    John Reed; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. A unique murine model for human aging
    Lea Harrington; Fiscal Year: 2008
    ..abstract_text> ..
  24. Society of Gynecologic Investigation Annual Meeting
    Andrew Berchuck; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. BLys inhibition using TACI-Fc in patients with B-bell non-Hodgkins' Lymphoma
    Stephen Ansell; Fiscal Year: 2008
    ..abstract_text> ..
  26. Chemical Inhibitors of ER Stress
    John Reed; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  27. Exisulind for Chemoprevention of Lung Cancer
    Gerold Bepler; Fiscal Year: 2007
    ..The data generated by these investigations will be important for future decisions on large-scale chemoprevention trials using disease incidence and mortality as endpoints. ..
  28. ER Reporter Genes To Predict Response To Endocrine Therapy
    WILLIAM SYMMANS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. Metabolomics and metabolic compartmentation in the brain
    Julian Griffin; Fiscal Year: 2006
    ..To correlate NMR observable metabolite changes with transcriptional changes. Our data will provide proof-of principle for this methodology, and establish a means for exploring other neurolodegenerative disorders. ..
  30. Development of Survivin as a Vaccine Target for Pancreatic Cancer
    Laszlo Radvanyi; Fiscal Year: 2007
    ..The epitope identification technology used in this project will also be critical in defining other future potential PC antigens. [unreadable] [unreadable] [unreadable]..
  31. A novel set of molecular markers to measure metastatic neuroblastoma
    Nai Kong Cheung; Fiscal Year: 2007
    ..Armed with the tools to collect samples expeditiously and to measure MRD accurately, the paradigm of treating subclinical NB can then be tested in multicenter randomized studies. [unreadable] [unreadable]..
  32. Regulation of Lung Epithelial Fibrinolysis by Urokinase
    Sreerama Shetty; Fiscal Year: 2005
    ..This information could hasten the development of new, mechanism-based interventions for lung disorders, including acute lung injury or lung neoplasia. ..
  33. Beta glucan enhances antibody therapy for neuroblastoma
    Nai Kong Cheung; Fiscal Year: 2003
    ..These findings will have general implications for antibody and vaccine strategies in human cancer models, and the role of polysaccharides as complementary/herbal medicine in immune-based therapies. ..
  34. Operant Responding in Opioid-Deficient Mice
    Malcolm Low; Fiscal Year: 2004
    ..abstract_text> ..
  35. CHARACTERIZATION AND SORTING OF ZYMOGEN GRANULE PROTEINS
    ANSON LOWE; Fiscal Year: 2004
    ..The model we propose to generate will provide important information on GP2 biology and may also provide potential models for human acute and chronic pancreatic diseases. ..
  36. Retinal Circadian Signaling in a Transgenic Model
    Allan Wiechmann; Fiscal Year: 2004
    ..Discovering the molecular mechanisms of melatonin action may therefore provide a greater understanding of the role of circadian signals in environmentally- and genetically- induced photoreceptor degenerations. ..
  37. CED-4 FAMILY PROTEINS
    John Reed; Fiscal Year: 2003
    ..The information provided by these investigations may provide insights into human diseases where dysregulation of programmed cell death is known to occur and may lead to new strategies for therapeutic intervention. ..
  38. MECHANISMS OF DIETARY MODULATION OF MELANOMA INVASION
    GARY MEADOWS; Fiscal Year: 2003
    ..abstract_text> ..
  39. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2008
    ..In this fashion we hope to establish whether Myc-induced genomic instability merits wider exploration in human neoplasm. [unreadable] [unreadable] [unreadable] [unreadable]..
  40. Prevention of Breast Cancer-Targeting COX-2 & PPARgamma
    ALAA BADAWI; Fiscal Year: 2003
    ..abstract_text> ..
  41. Workshop On Experimental Models from Bursa of Fabricius
    Paul Neiman; Fiscal Year: 2002
    ..This workshop will serve to stimulate further development and application, and to educate interested young scientists to the opportunities presented. ..
  42. NEUROPEPTIDES AND SMALL CELL CARCINOMA
    WILLIAM NORTH; Fiscal Year: 2002
    ..The information obtained is expected to result in effective chemotherapeutic and immunotherapeutic interventions for all patients with limited and extensive SCCL. ..
  43. HIV as a key regulator of c-MYB in human cells
    Robert Ramsay; Fiscal Year: 2004
    ..We hypothesize that Tat activates c-MYB in macrophages and that a thorough understanding of this process will advance our goal of blocking HIV transcription. ..
  44. Mechanisms of MMP-3 Action in Acute Lung Injury
    James Varani; Fiscal Year: 2005
    ..These studies will provide an overall understanding of the mechanism(s) by which MMP-3 contributes to acute lung injury. ..
  45. Non-viral Cutaneous Gene Delivery
    Mohammed Kashani Sabet; Fiscal Year: 2005
    ..We will determine whether efficient expression of the XPC gene in mice will alter the response to UV-mediated DNA damage. ..
  46. Quantitative RT-PCR: Prediction Lymphoma Transformation
    Kojo Elenitoba Johnson; Fiscal Year: 2005
    ....
  47. Microarray Analysis of HNSCC as a Predictor of Treatment
    Carol Shores; Fiscal Year: 2005
    ..In addition, microarray analysis will shed light on the molecular basis of cisplatin and radiation resistance in HNSCC. The arrays will also shed light on the molecular mechanism of resistance to therapy and control of apoptosis. ..
  48. Wnt Signaling in IBD-Related Colon Cancer
    RANDALL HOLCOMBE; Fiscal Year: 2005
    ..The precise effects of FIPs on Wnt signaling will be defined in vitro, with attention to the potentially disparate responses of different, specific, Fz receptor subtypes. ..
  49. Trk receptor mediated apoptosis of medulloblastoma cells
    Paul Mischel; Fiscal Year: 2005
    ..This team of internationally recognized mentors is committed to helping Dr. Mischel meet all of the aims of this proposal, and to ensure that he develops into an outstanding independent investigator. ..
  50. LINOLEIC ACID METABOLISM AND COLON CARCINOGENESIS
    Imad Shureiqi; Fiscal Year: 2005
    ..This work will set the stage for future animals and clinical studies of LA alternative pathway modulation as means of colon cancer chemoprevention. ..
  51. Inland Northwest Cancer Conference
    GARY MEADOWS; Fiscal Year: 2004
    ..The 2004 conference entitled "Bridging the Gap, Breakthroughs in Cancer Care and Research" will be held on November 12th and 13th at the Davenport Hotel in Spokane, WA. ..
  52. MOLECULAR CLASSIFICATION OF B-CELL LYMPHOMA
    Wing Chan; Fiscal Year: 2004
    ..The insights gained from this project may also identify novel targets for preventive and therapeutic interventions. ..
  53. TUMOR ANTIGEN PRESENTATION BY MICROGLIA
    HASSAN FATHALLAH SHAYKH; Fiscal Year: 2002
    ....
  54. GRSA Proteins in the Diagnosis of Breast Cancer
    WILLIAM NORTH; Fiscal Year: 2002
    ..These methods could be applicable to all patients with breast cancer or suspected breast cancer. ..
  55. SQUAMOUS EPITHELIAL CELL INVASION IN ORGAN CULTURE
    James Varani; Fiscal Year: 2001
    ..abstract_text> ..
  56. FSHD: Chromatin Structure, Looping, & Expression
    Melanie Ehrlich; Fiscal Year: 2009
    ..The proposed research should elucidate new aspects of long-distance control of gene expression as well as lending clinically useful insights into this currently intractable disease. ..
  57. Mechanisms on metastasis and survival in alcoholic mice
    Gary G Meadows; Fiscal Year: 2010
    ..Flow cytometric and ELISA assays will be used to determine lymphocyte populations, surface and intracellular marker expression, cytokine producing cells, and cytokine concentrations. ..
  58. Human RNA Binding Protein as a Cancer Marker
    Jeffrey Ross; Fiscal Year: 2003
    ..They might also stimulate future studies to evaluate the CRD-BP as a therapeutic target. ..
  59. Chemical Antagonists of IAP-Family Anti-Apoptotic Proteins
    John Reed; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. A Molecular Signature of Early Cervical Carcinoma
    Concepcion Diaz Arrastia; Fiscal Year: 2007
    ..I propose to identify a genomic and proteomic signature of cervical cancer that will predict the aggressive behavior of the tumor and function clinically to develop molecular-based treatment plans. ..
  61. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
    ..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
  62. Role of ornithine decarboxylase in Ras transformation
    Lisa Shantz; Fiscal Year: 2006
    ..Keratinocytes from D1/AZ mice will also be used to analyze direct interactions of AZ with cyclin D1, to test whether other properties of AZ are important for deregulation of cell proliferation in tumor development. ..
  63. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar E Bulun; Fiscal Year: 2010
    ..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..
  64. The Role of Chfr In Tumorigenesis
    Zheng Fu; Fiscal Year: 2007
    ..abstract_text> ..
  65. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2009
    ..Consequently, these aims are highly relevant to the vision statement of the NEI, and they address several major program goals and objectives of the Retinal Diseases Program. ..
  66. INHIBITION OF BREAST TUMORIGENICITY BY C MYC PO RNA
    SCOTT BLUME; Fiscal Year: 2002
    ..3. Assess the degree to which artificial manipulation of the PO 5'-untranslated sequence alters the inherent tumorigenic, invasive, and metastatic potential of human breast carcinoma xenografts in immunocompromised mice. ..
  67. Luminal Lipid Exposure, Genetics and Colon Cancer Risk
    Ikuko Kato; Fiscal Year: 2006
    ..In addition, accumulated dietary data and biological specimens will serve as an important resource for future research on other nutrient-gene interactions. ..
  68. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2008
    ..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
  69. Microarrays and Their Use To Study Mammalian Development
    Geoffrey Childs; Fiscal Year: 2004
    ..The approach we are using should implicate functional roles for a huge number of new genes for us and others to study in greater detail. ..
  70. Genetic Susceptibility to Infection Related Cancer
    Ikuko Kato; Fiscal Year: 2005
    ..Secondary aims include to examine histopathological correlates of these polymorphisms and to determine whether selected environmental factors modify the above associations. ..
  71. PixCell II Laser Capture Microdissection Instrument
    Geoffrey Childs; Fiscal Year: 2003
    ..abstract_text> ..
  72. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..