neoplasm dna

Summary

Summary: DNA present in neoplastic tissue.

Top Publications

  1. ncbi Gene expression profiling predicts clinical outcome of breast cancer
    Laura J van 't Veer
    Division of Diagnostic Oncology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands
    Nature 415:530-6. 2002
  2. pmc Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    T Sørlie
    Department of Genetics, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 98:10869-74. 2001
  3. ncbi CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Nat Genet 38:787-93. 2006
  4. ncbi DNA methylation in cancer: too much, but also too little
    Melanie Ehrlich
    Human Genetics Program SL31, Department of Biochemistry, Tulane Medical School, New Orleans, Louisiana, LA 70122, USA
    Oncogene 21:5400-13. 2002
  5. pmc Analysis of repetitive element DNA methylation by MethyLight
    Daniel J Weisenberger
    Department of Surgery, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California Los Angeles, CA, USA
    Nucleic Acids Res 33:6823-36. 2005
  6. ncbi DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells
    S Jahr
    Department of Biology, Universitat Konstanz, Germany
    Cancer Res 61:1659-65. 2001
  7. pmc Circulating mutant DNA to assess tumor dynamics
    Frank Diehl
    The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 14:985-90. 2008
  8. ncbi Circulating nucleic acids (CNAs) and cancer--a survey
    M Fleischhacker
    Charite, Universitatsmedizin Berlin, Medizinische Klinik mS Onkologie u Hämatologie, CCM, Chariteplatz 1, 10117 Berlin, Germany
    Biochim Biophys Acta 1775:181-232. 2007
  9. ncbi Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    Toshimi Takano
    Division of Internal Medicine, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Clin Oncol 23:6829-37. 2005
  10. ncbi Cancer epigenomics: DNA methylomes and histone-modification maps
    Manel Esteller
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Rev Genet 8:286-98. 2007

Research Grants

  1. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
  2. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  3. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  4. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
  5. Colorectal Cancer Screening: Fecal Blood vs DNA
    David Ahlquist; Fiscal Year: 2004
  6. FSHD Syndrome: DNA Repeats, Methylation, & Chromatin
    Melanie Ehrlich; Fiscal Year: 2003
  7. Statistical Models in Epigenomics
    Kimberly Siegmund; Fiscal Year: 2007
  8. FSHD: Chromatin Structure, Looping, & Expression
    Melanie Ehrlich; Fiscal Year: 2009
  9. Flow Cytometry to Detect Human Tumor Cells in Body Fluid
    AWTAR GANJU KRISHAN; Fiscal Year: 2003
  10. Characterization of the Chromosome 17q23 Amplicon
    Fergus Couch; Fiscal Year: 2006

Detail Information

Publications317 found, 100 shown here

  1. ncbi Gene expression profiling predicts clinical outcome of breast cancer
    Laura J van 't Veer
    Division of Diagnostic Oncology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands
    Nature 415:530-6. 2002
    ..This gene expression profile will outperform all currently used clinical parameters in predicting disease outcome. Our findings provide a strategy to select patients who would benefit from adjuvant therapy...
  2. pmc Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    T Sørlie
    Department of Genetics, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 98:10869-74. 2001
    ....
  3. ncbi CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Nat Genet 38:787-93. 2006
    ..Sporadic cases of mismatch repair deficiency occur almost exclusively as a consequence of CIMP-associated methylation of MLH1 . We propose a robust new marker panel to classify CIMP+ tumors...
  4. ncbi DNA methylation in cancer: too much, but also too little
    Melanie Ehrlich
    Human Genetics Program SL31, Department of Biochemistry, Tulane Medical School, New Orleans, Louisiana, LA 70122, USA
    Oncogene 21:5400-13. 2002
    ..Inducing DNA hypomethylation may have short-term anticancer effects, but might also help speed tumor progression from cancer cells surviving the DNA demethylation chemotherapy...
  5. pmc Analysis of repetitive element DNA methylation by MethyLight
    Daniel J Weisenberger
    Department of Surgery, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California Los Angeles, CA, USA
    Nucleic Acids Res 33:6823-36. 2005
    ....
  6. ncbi DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells
    S Jahr
    Department of Biology, Universitat Konstanz, Germany
    Cancer Res 61:1659-65. 2001
    ..The data are consistent with the possibility that apoptotic and necrotic cells are a major source for plasma DNA in cancer patients...
  7. pmc Circulating mutant DNA to assess tumor dynamics
    Frank Diehl
    The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 14:985-90. 2008
    ..We suggest that this personalized genetic approach could be generally applied to individuals with other types of cancer...
  8. ncbi Circulating nucleic acids (CNAs) and cancer--a survey
    M Fleischhacker
    Charite, Universitatsmedizin Berlin, Medizinische Klinik mS Onkologie u Hämatologie, CCM, Chariteplatz 1, 10117 Berlin, Germany
    Biochim Biophys Acta 1775:181-232. 2007
    ..At the RNA level the overexpression of tumor-associated genes was shown. These observations laid the foundation for the development of assays for an early detection of cancer as well as for other clinical means...
  9. ncbi Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    Toshimi Takano
    Division of Internal Medicine, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Clin Oncol 23:6829-37. 2005
    ..To evaluate epidermal growth factor receptor (EGFR) mutations and copy number as predictors of clinical outcome in patients with non-small-cell lung cancer (NSCLC) receiving gefitinib...
  10. ncbi Cancer epigenomics: DNA methylomes and histone-modification maps
    Manel Esteller
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Rev Genet 8:286-98. 2007
    ..It is time to 'upgrade' cancer epigenetics research and put together an ambitious plan to tackle the many unanswered questions in this field using epigenomics approaches...
  11. ncbi The DNA methylation paradox
    P A Jones
    Department of Biochemistry and Molecular Biology, University of Southern, California Norris Comprehensive Cancer Center and Hospital, Los Angeles 90033 0800, USA
    Trends Genet 15:34-7. 1999
    ..The methylation paradox might be resolved if it is hypothesized that transcription through a CpG island facilitates de novo methylation...
  12. ncbi Identification of the breast cancer susceptibility gene BRCA2
    R Wooster
    Section of Molecular Carcinogenesis, Haddow Laboratories, Sutton Surrey, UK
    Nature 378:789-92. 1995
    ..Each mutation causes serious disruption to the open reading frame of the transcriptional unit. The results indicate that this is the BRCA2 gene...
  13. ncbi DNA methylation, methyltransferases, and cancer
    K D Robertson
    Epigenetic Gene Regulation and Cancer Section, National Cancer Institute, NIH, Bldg. 41, 41 Library Dr, Bethesda, Maryland, MD 20892, USA
    Oncogene 20:3139-55. 2001
    ..These new findings will likely enhance our understanding of the myriad roles of DNA methylation in disease as well as point the way to novel therapies to prevent or repair these defects...
  14. ncbi Quantification of free circulating DNA as a diagnostic marker in lung cancer
    Gabriella Sozzi
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 21:3902-8. 2003
    ..This study was designed to assess the sensitivity and specificity of a quantitative molecular assay of circulating DNA to identify patients with lung cancer and monitor their disease...
  15. ncbi Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer
    Anna Bergamaschi
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Genes Chromosomes Cancer 45:1033-40. 2006
    ..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat..
  16. ncbi DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
    Ina Rhee
    The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 416:552-6. 2002
    ..Here we demonstrate that two enzymes cooperatively maintain DNA methylation and gene silencing in human cancer cells, and provide compelling evidence that such methylation is essential for optimal neoplastic proliferation...
  17. ncbi CGHcall: calling aberrations for array CGH tumor profiles
    Mark A van de Wiel
    Department of Pathology, VU University Medical Center, PO Box 7057, 1007MB Amsterdam, The Netherlands
    Bioinformatics 23:892-4. 2007
    ..By incorporating more than three classes, CGHcall improves detection of single copy gains and amplifications. Moreover, it allows effective inclusion of chromosome arm information...
  18. ncbi Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients
    P Anker
    Laboratoire de Biochimie et Physiologie Végétale, Pavillon des Isotopes, University of Geneva, Switzerland
    Cancer Metastasis Rev 18:65-73. 1999
    ..The results obtained in many different cancers have opened a new research area indicating that plasma DNA might eventually be a suitable target for the development of non-invasive diagnostic, prognostic and follow-up tests for cancer...
  19. pmc A multiplex PCR predictor for aCGH success of FFPE samples
    E H van Beers
    Division of Experimental Therapy, Netherlands Cancer Institute NKI AvL, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Br J Cancer 94:333-7. 2006
    ....
  20. ncbi Detection of aberrant methylation of four genes in plasma DNA for the detection of breast cancer
    Mohammad O Hoque
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Clin Oncol 24:4262-9. 2006
    ..In this study, we explored the hypothesis that blood-based biomarkers have potential for biomarkers for breast cancer...
  21. ncbi DNA methylation and gene silencing in cancer: which is the guilty party?
    Susan J Clark
    Sydney Cancer Centre, Kanematsu Laboratories, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia
    Oncogene 21:5380-7. 2002
    ....
  22. ncbi Large DNA palindromes as a common form of structural chromosome aberrations in human cancers
    Hisashi Tanaka
    Division of Basic Sciences, Fred Hitchinson Cancer Research Center, Seattle, Washington, USA
    Hum Cell 19:17-23. 2006
    ..A subset of loci containing palindromes is associated with gene amplification in Colo320DM, indicating that the location of palindromes in the cancer genome serves as a structural platform that supports subsequent gene amplification...
  23. ncbi Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis
    Brian T Ragel
    Department of Neurosurgery, University of Utah, Salt Lake City, UT 84132, USA
    Neurosurg Rev 30:181-7; discussion 187. 2007
    ..Future studies will focus on the hypothesis that Depp is up-regulated in an autocrine fashion by the AKR1C3 enzyme in U-251 glioma cells under hypoxic conditions...
  24. ncbi Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells
    Dolores C García-Olmo
    Experimental Research Unit, General University Hospital of Albacete, Albacete, Spain
    Cancer Res 70:560-7. 2010
    ..4 mum. Our results indicate that plasma from cancer patients is able to transform cultured cells oncogenically, supporting the previously proposed hypothesis of genometastasis...
  25. ncbi Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage
    G M Brodeur
    Science 224:1121-4. 1984
    ..Furthermore, N-myc amplification is highly correlated with advanced stages of disease (P less than 0.001) and with the ability to grow in vitro as an established cell line, both of which are associated with a poor prognosis...
  26. ncbi Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells
    Fenghuang Zhan
    Donna D and Donald M Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Blood 99:1745-57. 2002
    ..Thus, novel candidate MM disease genes have been identified using gene expression profiling and this profiling has led to the development of a gene-based classification system for MM...
  27. ncbi Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors
    Nada Al-Tassan
    Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Nat Genet 30:227-32. 2002
    ..Our findings link the inherited variants in MYH to the pattern of somatic APC mutation in family N and implicate defective base excision repair in predisposition to tumors in humans...
  28. ncbi DNA alterations in body fluids as molecular tumor markers for urological malignancies
    Carsten Goessl
    Department of Urology, Benjamin Franklin Medical School, Free University Berlin, Berlin, Germany
    Eur Urol 41:668-76. 2002
    ..Both cell-free tumor DNA circulating in plasma/serum and cellular tumor DNA are detectable by minimally invasive measures...
  29. ncbi p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine
    Hua Bai
    Department of Cancer Etiology, Peking University Health Science Center and Beijing Institute for Cancer Research, Da Hong Luo Chang Street, Western District, Beijing 100034, China
    Mutat Res 535:73-8. 2003
    ..These results suggest that CpG island hypermethylation may account for the silencing of p16 in rat stomach and is an early event whose accumulation will finally lead to gastric carcinogenesis...
  30. ncbi Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors
    A Koch
    Department of Neuropathology, University of Bonn Medical Center; Bonn, Germany
    Int J Cancer 93:445-9. 2001
    ..Our data indicate that inappropriate activation of the WNT/wingless signaling pathway by mutations of its components may contribute to the pathogenesis of a subset of PNETs...
  31. ncbi Influence of methylated p15 and p16 genes on clinicopathological features in colorectal cancer
    Atsushi Ishiguro
    First Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    J Gastroenterol Hepatol 21:1334-9. 2006
    ..We investigated p15(INK4b) methylation status in patients with colorectal cancer to verify the association between the methylation of p15(INK4b) and clinicopathological features compared with p16(INK4a)...
  32. ncbi Circulating plasma DNA as diagnostic biomarker in non-small cell lung cancer
    Massimiliano Paci
    Division of Thoracic Surgery, Azienda Ospedaliera Santa Maria Nuova, Viale Risorgimento 80, 42100 Reggio Emilia, Italy
    Lung Cancer 64:92-7. 2009
    ..A second aim of this work is the sensibility and specificity evaluation of such method for future applications...
  33. pmc E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers
    G Berx
    Laboratory of Molecular Biology, University of Ghent, Belgium
    EMBO J 14:6107-15. 1995
    ..These findings offer a molecular explanation for the typical scattered tumour cell growth in infiltrative lobular breast cancer...
  34. ncbi Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer
    W M Grady
    Department of Medicine, Ireland Cancer Center, Case Western Reserve University, University Hospitals of Cleveland, Ohio 44106, USA
    Cancer Res 61:900-2. 2001
    ..This assay offers a potential means for the serum-based detection and/or monitoring of microsatellite unstable colon cancers...
  35. pmc Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylation
    T E Skvortsova
    Institute of Chemical Biology and Fundamental Medicine, SD RAS, Lavrentiev Ave, Novosibirsk 630090, Russia
    Br J Cancer 94:1492-5. 2006
    ....
  36. ncbi Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia
    Cumhur G Ekmekci
    Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey
    Am J Hematol 77:233-40. 2004
    ..FAB M3 demonstrated a higher extent of methylation than M2/M4. This study provides an impetus for larger studies to define if the extent and pattern of methylation in subgroups of AML are clinically relevant...
  37. ncbi Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation
    Xinyu S Fu
    Cancer Biology Program, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Prostate 63:215-21. 2005
    ..Although HIF-1alpha stabilization appears to be the molecular basis for VHL-associated cancers, stabilizing mutations in HIF-1alpha have not been reported...
  38. ncbi Prevalence and importance of internal tandem duplications in exons 11 and 12 of c-kit in mast cell tumors of dogs
    Sue Downing
    Veterinary Cancer Referral Group, 1044 South Robertson Blvd, Los Angeles, CA 90035, USA
    Am J Vet Res 63:1718-23. 2002
    ..To determine the prevalence of activating internal tandem duplications (ITDs) in exons 11 and 12 of c-kit in mast cell tumors (MCTs) of dogs and to correlate these mutations with prognosis...
  39. ncbi Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-small-cell lung cancer
    Hideharu Kimura
    Shien Lab, Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Clin Cancer Res 12:3915-21. 2006
    ..These results suggest that patients with EGFR mutations seem to have better outcomes with gefitinib treatment, in terms of progression-free survival, overall survival, and response, than those patients without EGFR mutations...
  40. ncbi Widespread and nonrandom distribution of DNA palindromes in cancer cells provides a structural platform for subsequent gene amplification
    Hisashi Tanaka
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nat Genet 37:320-7. 2005
    ..Genome-wide analysis of palindrome formation is a new approach to identify structural chromosome aberrations associated with cancer...
  41. ncbi Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors
    Noralane M Lindor
    Department of Medical Genetics, Mayo Foundation, Rochester, MN 55905, USA
    J Clin Oncol 20:1043-8. 2002
    ..To compare microsatellite instability (MSI) testing with immunohistochemical (IHC) detection of hMLH1 and hMSH2 in colorectal cancer...
  42. ncbi Methylation of serum DNA is an independent prognostic marker in colorectal cancer
    Maike Wallner
    Department of Medicine II, University Hospital Grosshadern, University of Munich, Munich, Germany
    Clin Cancer Res 12:7347-52. 2006
    ..This study was designed to identify methylation targets with prognostic significance in the serum of patients with colorectal cancer...
  43. ncbi Telomere dysfunction: a potential cancer predisposition factor
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 95:1211-8. 2003
    ..Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between telomere length and cancer risk in four ongoing case-control studies...
  44. ncbi Inhibition of hsp90 compromises the DNA damage response to radiation
    Hideaki Dote
    Molecular Radiation Therapeutics and Radiation Oncology Branches, National Cancer Institute, Bethesda, Maryland
    Cancer Res 66:9211-20. 2006
    ..These data indicate that Hsp90 can contribute to the DNA damage response to radiation affecting both DNA repair and cell cycle checkpoint activation...
  45. ncbi Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance
    Emmanuelle Gormally
    Université Catholique de Lyon, 25 rue du Plat, 69288 Lyon Cedex 02, France
    Mutat Res 635:105-17. 2007
    ..Testing these hypotheses will require well-designed studies, assessing multiple markers with quantitative and sensitive methods, with adequate follow-up of subjects, and we provide recommendations for the development of such studies...
  46. ncbi DNA hypermethylation in tumorigenesis: epigenetics joins genetics
    S B Baylin
    The Johns Hopkins Oncology Center, 1650 East Orleans Street, Baltimore, MD 21231, USA
    Trends Genet 16:168-74. 2000
    ..Methylation changes constitute potentially sensitive molecular markers to define risk states, monitor prevention strategies, achieve early diagnosis, and track the prognosis of cancer...
  47. ncbi DNA methylation, chromatin inheritance, and cancer
    M R Rountree
    The Johns Hopkins Oncology Center, Tumor Biology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21231, USA
    Oncogene 20:3156-65. 2001
    ....
  48. ncbi Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 7076, Rockville, MD 20952 7234, USA
    Hum Genet 119:376-88. 2006
    ..Evaluation of potential underlying gene-gene interactions or associations in population subgroups will require even larger sample sizes...
  49. ncbi Contributions of ATM mutations to familial breast and ovarian cancer
    Yvonne R Thorstenson
    Stanford Genome Technology Center, Palo Alto, California 94304 1103, USA
    Cancer Res 63:3325-33. 2003
    ..This study indicates that there is a significant prevalence of ATM mutations in breast and ovarian cancer families and adds to a growing body of evidence that ATM mutations confer increased susceptibility to breast cancer...
  50. ncbi Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs
    D Zemke
    Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA
    Vet Pathol 39:529-35. 2002
    ..A significant association was found between the presence of a mutation and a higher grade of tumor but not between breed and grade or between breed and the presence of a mutation...
  51. ncbi Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas
    Sheng Zhong
    Department of Clinical Oncology, Sir Y K Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong SAR, China
    Clin Cancer Res 8:1087-92. 2002
    ....
  52. ncbi Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
    Manel Esteller
    Division of Cancer Biology, The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
    J Natl Cancer Inst 94:26-32. 2002
    ..MGMT promoter hypermethylation is a favorable prognostic marker in patients with brain tumors treated with alkylating agents...
  53. pmc Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
    S Ziemin-van der Poel
    Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637
    Proc Natl Acad Sci U S A 88:10735-9. 1991
    ..We have named this gene MLL (myeloid/lymphoid, or mixed-lineage, leukemia...
  54. ncbi Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
    S Markowitz
    Department of Medicine, University Hospitals of Cleveland, OH, USA
    Science 268:1336-8. 1995
    ..RII mutation, by inducing the escape of cells from TGF-beta-mediated growth control, links DNA repair defects with a specific pathway of tumor progression...
  55. ncbi Detection of hypermethylated genes in women with and without cervical neoplasia
    Qinghua Feng
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    J Natl Cancer Inst 97:273-82. 2005
    ..We examined whether DNA methylation changes might be used as markers of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC)...
  56. ncbi Promoter methylation and silencing of PTEN in gastric carcinoma
    Young Hwa Kang
    Cancer Research Institute, Seoul National University College of Medicine and BK21 Project for Medicine, Dentistry and Pharmacy, Seoul, Korea
    Lab Invest 82:285-91. 2002
    ..The abnormalities of the PTEN gene are associated with tumor progression, metastasis, and survival...
  57. ncbi Quantitative analysis of circulating plasma DNA as a tumor marker in thoracic malignancies
    Luis J Herrera
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Chem 51:113-8. 2005
    ..The objectives of this study were to develop a controlled, quantitative PCR (QPCR) assay to measure plasma DNA and then evaluate plasma DNA concentrations as a tumor marker in patients with thoracic malignancies...
  58. ncbi Principle and applications of digital PCR
    Gudrun Pohl
    Department of Pathology, 418 North Bond Street, B 315, Baltimore, MD 21231, USA
    Expert Rev Mol Diagn 4:41-7. 2004
    ..The scope of this article is to review the principles of digital PCR and its practical applications in cancer research and in the molecular diagnosis of cancer...
  59. ncbi PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer
    M G Ghosh
    Department of Surgery, Stanford University, California 94305, USA
    Cancer Res 60:6367-75. 2000
    ..5-fold, respectively. GREB1 was also induced by beta-estradiol in the ER-positive endometrial cell line ECC-1. The pattern of expression suggests a critical role for these two genes in the response of tissues and tumors to beta-estradiol...
  60. ncbi Gene promoter methylation in plasma and sputum increases with lung cancer risk
    Steven A Belinsky
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Clin Cancer Res 11:6505-11. 2005
    ..The prevalence for methylation of seven and three genes was examined in DNA from sputum and plasma, respectively, from women at different risk for lung cancer...
  61. ncbi Characterization of amplicons in neuroblastoma: high-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes
    Anne Fix
    INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Genes Chromosomes Cancer 47:819-34. 2008
    ..Finally, our results suggest that the presence of amplicons localized outside of chromosome 2, in addition to MYCN amplification, may be linked to a particularly severe outcome in neuroblastoma patients...
  62. ncbi Delineation of prognostic biomarkers in prostate cancer
    S M Dhanasekaran
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 412:822-6. 2001
    ..Thus, the integration of cDNA microarray, high-density tissue microarray, and linked clinical and pathology data is a powerful approach to molecular profiling of human cancer...
  63. ncbi Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification
    Richard Simon
    Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:14-8. 2003
  64. ncbi RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression
    Manish Mani Subramaniam
    Oncology Research Institute, National University of Singapore, Singapore, Republic of Singapore
    Breast Cancer Res Treat 113:113-21. 2009
    ..Here, we hypothesize that inactivation of RUNX3 occurring in ductal carcinoma in situ (DCIS) represent early event in breast carcinogenesis...
  65. ncbi Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients
    G Sozzi
    Department of Experimental Oncology, Unit of Immunohematology, Istituto Nazionale Tumori, 20133 Milan, Italy
    Cancer Res 61:4675-8. 2001
    ....
  66. pmc Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma
    M Pufulete
    Nitritional Sciences Research Division, Department of Nutrition and Dietetics, King s College London, Franklin Wilkins Building, 150 Stamford St, London SE1 9NH, UK
    Gut 54:648-53. 2005
    ....
  67. ncbi Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes
    Lenora W M Loo
    Division of Human Biology, Division of Public Health Sciences, and Genomics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:8541-9. 2004
    ..These results indicate that array comparative genomic hybridization can identify significant differences in the genomic alterations between subtypes of breast cancer...
  68. ncbi Promoter methylation of p16, DAPK, CDH1, and TIMP-3 genes in cervical cancer: correlation with clinicopathologic characteristics
    D H Jeong
    Department of Obstetrics and Gynecology, Paik Institute for Clinical Research, and Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, 633 165 Gaegum Dong, Busanjin Gu, Busan 614 735, South Korea
    Int J Gynecol Cancer 16:1234-40. 2006
    ..0061). The promoter methylation of the p16 gene is a frequent event in cervical carcinogenesis and may have potential clinical application as a marker for the progression and prognosis of cancer...
  69. ncbi Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR
    Nirosha Suraweera
    INSERM U434, Centre d Etudes du Polymorphisme Humain, Paris, France
    Gastroenterology 123:1804-11. 2002
    ..Analysis of BAT-26 is sufficient for detecting the MSI phenotype in most, but not all, cases. Additional results with dinucleotide markers can sometimes lead to incorrect classification of MSI tumors...
  70. pmc Genome-wide analysis of allelic imbalance in prostate cancer using the Affymetrix 50K SNP mapping array
    N Tørring
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Skejby Sygehus, Aarhus University Hospital, Brendstrupgaardsvej 100, DK 8200 Aarhus, Denmark
    Br J Cancer 96:499-506. 2007
    ..In conclusion, patterns of allelic imbalance were discovered in PCa, consisting allelic loss as an early event in tumour development, and distinct patterns of allelic amplification related to tumour progression and poor differentiation...
  71. ncbi In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco 94143 0560, USA
    Blood 99:3801-5. 2002
    ....
  72. ncbi Prediction of breast tumor progression by integrity of free circulating DNA in serum
    Naoyuki Umetani
    Department of Molecular Oncology and the Joyce Eisenberg Breast Center, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    J Clin Oncol 24:4270-6. 2006
    ..Serum DNA integrity, the ratio of longer fragments to total DNA, may be clinically useful for detecting breast cancer progression...
  73. pmc Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma
    Ying Hao
    Department of Medicine, Stanford University, Stanford, California 94305 5187, USA
    Gastroenterology 131:925-33. 2006
    ....
  74. ncbi Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer
    Xin Lin
    Departments of Epidemiology and Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 12:5720-5. 2006
    ..We hypothesized that the expression of these genes would have significant predictive value for cancer development and prognosis...
  75. ncbi The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis
    Reiko Dehari
    Department of Pathology, Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 31:1007-12. 2007
    ..The above results suggest that the majority of high-grade and low-grade carcinomas develop independently but in rare cases, a high-grade serous carcinoma may arise from an atypical proliferative serous (borderline) tumor...
  76. ncbi c-KIT mutation analysis for diagnosis of gastrointestinal stromal tumors in fine needle aspiration specimens
    Carlynn Willmore-Payne
    ARUP Laboratories, Salt Lake City, Utah 84108, USA
    Cancer 105:165-70. 2005
    ..Antigen retrieval may be the cause of this spurious positivity. Recently, the demonstration of KIT and PDGFRA mutations has been shown to be more reliable in establishing the diagnosis of GIST than IHC...
  77. ncbi Reliable high-throughput genotyping and loss-of-heterozygosity detection in formalin-fixed, paraffin-embedded tumors using single nucleotide polymorphism arrays
    Esther H Lips
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Cancer Res 65:10188-91. 2005
    ..These data show that genome-wide genotyping of FFPE tissue with the BeadArray gives reliable results and is a powerful technique for LOH analysis...
  78. ncbi Evidence for a novel gene associated with low tumor metastatic potential
    P S Steeg
    Division of Cancer Biology and Diagnosis, National Cancer Institute, Bethesda, MD 20892
    J Natl Cancer Inst 80:200-4. 1988
    ..The predicted carboxy-terminal protein sequence encoded by the pNM23 cDNA clone is novel compared with Genebank animal, bacterial, and viral sequences...
  79. ncbi Cancer epigenetics
    Richard L Momparler
    Département de pharmacology, Universite de Montreal, Centre de Recherche, Hopital Sainte Justine, 3175 Côte Ste Catherine Montreal, Que H3T 1C5, Canada
    Oncogene 22:6479-83. 2003
    ....
  80. ncbi MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group
    Naji Aldosari
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Arch Pathol Lab Med 126:540-4. 2002
    ..Data on these tumors indicate that the frequency of MYCC amplification is 5% to 10%. Fluorescence in situ hybridization is a powerful tool for investigating these features on archival material...
  81. ncbi Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma
    Sokbom Kang
    Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Republic of Korea
    Int J Cancer 118:2168-71. 2006
    ..0% vs. 33.3%, p = 0.001). In conclusion, the existence of these unique methylation patterns in these cancers suggests that their tumorigenesis may involve different epigenetic mechanisms...
  82. pmc Monitoring of circulating tumour-associated DNA as a prognostic tool for oral squamous cell carcinoma
    K Hamana
    Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Br J Cancer 92:2181-4. 2005
    ..Thus, our results suggest that the assessment of microsatellite status in the serum DNA could be a useful predictive tool to monitor disease prognosis...
  83. ncbi Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    Michael C Heinrich
    R and D 19 3710 SW US Veterans Hospital Rd, Portland, OR 97207, USA
    J Clin Oncol 21:4342-9. 2003
    ..The relationship between mutations in these kinases and clinical response to imatinib was examined in a group of patients with advanced GIST...
  84. ncbi MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells
    Tibor Rauch
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Cancer Res 66:7939-47. 2006
    ..The results support the hypothesis that cancer-associated DNA methylation events do not occur randomly throughout the genome but at least some are targeted by specific mechanisms...
  85. ncbi Circulating fragmented nucleosomal DNA and caspase-3 mRNA in patients with lymphoma and myeloma
    Ugur Deligezer
    Department of Basic Oncology, Oncology Institute, Istanbul University, Capa, Istanbul 34390, Turkey
    Exp Mol Pathol 80:72-6. 2006
    ..These findings suggest that nucleosomal DNA fragmentation is not correlated with elevated levels of apoptosis and circulating caspase-3 mRNA in circulating tumor cells...
  86. ncbi Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays
    Mitchell Stark
    Oncogenomics Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Cancer Res 67:2632-42. 2007
    ....
  87. ncbi Detection of EGFR- and HER2-activating mutations in squamous cell carcinoma involving the head and neck
    Carlynn Willmore-Payne
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Mod Pathol 19:634-40. 2006
    ..HRMAA could serve as a screening method to easily and rapidly identify these patients...
  88. ncbi Methylated DNA as a possible screening marker for neoplastic disease in several body fluids
    Hannes M Müller
    Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria
    Expert Rev Mol Diagn 3:443-58. 2003
    ..Due to the ubiquity of DNA methylation changes and the possibility to detect methylated DNA in several body fluids, this specifically altered DNA may serve as a potential new screening marker for neoplastic disease...
  89. ncbi The effect of human tissue factor pathway inhibitor-2 on the growth and metastasis of fibrosarcoma tumors in athymic mice
    Hitendra Singh Chand
    Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Blood 103:1069-77. 2004
    ..Our collective data demonstrate that secretion of inhibitory TFPI-2 by a highly metastatic tumor cell markedly inhibits its growth and metastasis in vivo by regulating pericellular extracellular matrix (ECM) remodeling and angiogenesis...
  90. pmc Multiple mutation analyses in single tumor cells with improved whole genome amplification
    W Dietmaier
    Institute of Pathology, The Department of Surgery, University of Regensburg, Germany
    Am J Pathol 154:83-95. 1999
    ....
  91. ncbi Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers
    Susan H Wei
    Department of Pathology and Anatomical Sciences, Ellis Fischel Cancer Center, University of Missouri, Columbia, Missouri 65203, USA
    Clin Cancer Res 8:2246-52. 2002
    ..The purpose of this study was to profile methylation alterations of CpG islands in ovarian tumors and to identify candidate markers for diagnosis and prognosis of the disease...
  92. ncbi Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survival
    Jose M Silva
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, E 28035 Madrid, Spain
    Clin Cancer Res 8:3761-6. 2002
    ..We examine prospectively whether the presence of plasma DNA with tumor characteristics before mastectomy is a predictive factor related to recurrence and disease-free survival (DFS)...
  93. ncbi Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients
    S L Rosas
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21206-2198, USA
    Cancer Res 61:939-42. 2001
    ..Long-term longitudinal studies are needed to evaluate this approach for early detection of head and neck cancer in at-risk populations...
  94. ncbi Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma
    Kazuhiro Ogi
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Sapporo, Japan
    Clin Cancer Res 8:3164-71. 2002
    ..71; 95% confidence interval, 1.25-26.07). Analysis of DNA methylation is a useful approach to evaluation of the biological characteristics of oral cancers and may be a useful diagnostic indicator of patient prognosis...
  95. pmc Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays
    Go Yamamoto
    Departments of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Hum Genet 81:114-26. 2007
    ..In conclusion, AsCNAR should substantially improve our ability to dissect the complexity of cancer genomes and should contribute to our understanding of the genetic basis of human cancers...
  96. ncbi Quantification of circulating plasma DNA fragments as tumor markers in patients with esophageal cancer
    Haruhisa Tomita
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Anticancer Res 27:2737-41. 2007
    ..The quantity and quality of circulating DNA fragments was analyzed by quantitative real-time polymerase chain reactions (qPCR) in plasma from patients with esophageal carcinomas, in order to assess their diagnostic value...
  97. pmc Methylation mediated silencing of TMS1/ASC gene in prostate cancer
    Partha M Das
    Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA
    Mol Cancer 5:28. 2006
    ..We also examined the prevalence of TMS1/ASC gene methylation in prostate cancer tissue samples in an effort to correlate race and clinico-pathological features with TMS1/ASC gene methylation...
  98. pmc Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA)
    H Kimura
    Department of Respiratory Medicine, Kanazawa University Hospital, Takara machi 13 1, Kanazawa, Ishikawa, Japan
    Br J Cancer 97:778-84. 2007
    ..044, in serum samples). The results suggest that it is feasible to use serum DNA to detect EGFR mutation, and that it's potential as a predictor of response to, and survival on gefitinib is worthy of further evaluation...
  99. ncbi MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells
    Norishige Yamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
    Cancer Res 68:2708-16. 2008
    ..An understanding of the epigenetic changes of MUC1 may be of importance for diagnosis of carcinogenic risk and prediction of outcome for cancer patients...
  100. ncbi Universal linkage system: an improved method for labeling archival DNA for comparative genomic hybridization
    J C Alers
    Department of Pathology, Erasmus University Rotterdam, The Netherlands
    Genes Chromosomes Cancer 25:301-5. 1999
    ..We conclude that ULS is an excellent labeling method for performing CGH on small-fragment-sized DNA...
  101. ncbi Clonality and stability of the p53 gene in human astrocytic tumor cells: quantitative analysis of p53 gene mutations by yeast functional assay
    M Tada
    Department of Neurosurgery, University of Hokkaido School of Medicine, Sapporo, Japan
    Int J Cancer 67:447-50. 1996
    ..Our results demonstrate the utility of the p53 functional assay for studies of clonality and support the hypothesis of clonal progression of brain tumors in vivo...

Research Grants72

  1. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  2. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  3. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  4. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  5. Colorectal Cancer Screening: Fecal Blood vs DNA
    David Ahlquist; Fiscal Year: 2004
    ..If the DNA-based test proves to have greater screening accuracy than fecal blood testing, this could translate into more effective cancer control and more efficient use of our limited health care resources. ..
  6. FSHD Syndrome: DNA Repeats, Methylation, & Chromatin
    Melanie Ehrlich; Fiscal Year: 2003
    ..The proposed research should help elucidate the molecular etiology of the enigmatic FSHD syndrome. ..
  7. Statistical Models in Epigenomics
    Kimberly Siegmund; Fiscal Year: 2007
    ..4. Apply the methods to DNA methylation patterns observed in primary tumors of the colon and distant metastasis in humans and in mice. [unreadable] [unreadable] [unreadable] [unreadable]..
  8. FSHD: Chromatin Structure, Looping, & Expression
    Melanie Ehrlich; Fiscal Year: 2009
    ..The proposed research should elucidate new aspects of long-distance control of gene expression as well as lending clinically useful insights into this currently intractable disease. ..
  9. Flow Cytometry to Detect Human Tumor Cells in Body Fluid
    AWTAR GANJU KRISHAN; Fiscal Year: 2003
    ..3. Compare data collected from flow cytometric analysis with that obtained from cytopathology and immunocytochemistry routinely performed on these specimens for diagnostic purpose. ..
  10. Characterization of the Chromosome 17q23 Amplicon
    Fergus Couch; Fiscal Year: 2006
    ..Thus, the project may involve a complete transition from benchtop to bedside. Finally, the amplified and overexpressed genes may prove useful as important targets of gene, pharmacological, and immunological therapy in the future. ..
  11. P21 INDUCTION BY BRCA2
    Fergus Couch; Fiscal Year: 2002
    ....
  12. Voice-preserving Treatment of Larynegeal Papilloma
    Zhi Wang; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  13. Effects of Loss of TGF-Beta Rll in the Liver
    William Grady; Fiscal Year: 2006
    ..abstract_text> ..
  14. Array-based methylation analysis using anti-5mC antibody
    Fumiichiro Yamamoto; Fiscal Year: 2007
    ..We will evaluate the sensitivity, specificity, and reproducibility of the method, using BAG clone microarrays, DNA fragment microarrays, and oligonucleotide microarrays. [unreadable] [unreadable] [unreadable]..
  15. Biology of Breast Cancers Arising in Older Women
    Christopher Benz; Fiscal Year: 2007
    ..abstract_text> ..
  16. Genetics/microsatellite instability in tumor suppressors
    Hanlee Ji; Fiscal Year: 2007
    ..To accomplish this goal, I will screen a cDNA library derived from normal colon tissue for new genes which are susceptible to microsatellite instability mutations. ..
  17. Prognostic Significance of DNA and Histone Methylation
    Chandrika Piyathilake; Fiscal Year: 2007
    ..Investigator talent, equipment, facilities and access to study subjects at UAB are ideal for conducting this study. ..
  18. Protein Profiling in Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..abstract_text> ..
  19. Melanoma NRAS/BRAF Mutations: A Population-Based Study
    Nancy Thomas; Fiscal Year: 2007
    ..This study is also expected to lead to identification of new hemotherapeutic targets and more efficient testing of inhibitors for NRAS and BRAF signaling, which have recently been developed. ..
  20. Regulation of the von Hippel-Lindau Protein
    Paul Corn; Fiscal Year: 2007
    ..abstract_text> ..
  21. Soyfood, gene polymorphisms and endometrial cancer risk
    Xiao Ou Shu; Fiscal Year: 2010
    ..abstract_text> ..
  22. Genomic Analysis of Tumor Context Vulnerabilities in Human Metastatic Melanoma
    Jeffrey M Trent; Fiscal Year: 2010
    ..The proposed research aims to identify genetic vulnerabilities acquired by metastatic melanoma cells that may be exploited to improve the effectiveness of clinical intervention in this disease. ..
  23. Meningioma: Risk Factors and Quality of Life
    JOSEPH LEO WIEMELS; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  24. Epigenetic regulation of cancer/germ-line antigen gene expression
    Adam R Karpf; Fiscal Year: 2010
    ..Furthermore, this study will provide key information relevant for understanding the outcome and improving the future design of clinical vaccine trials for the treatment of ovarian cancer. ..
  25. TUMOR SUPPRESSOR GENE METHYLATION IN LUNG ADENOCARCINOMA
    Steven A Belinsky; Fiscal Year: 2010
    ..Transient transfection of minimized promoters into cell lines with an endogenously active or silenced gene will be used to elucidate the sequence of changes involved in repression of promoter activity. REVISED: July 7, 2005 ..
  26. Mitochondrial Gene Expression Changes Related to a Symptom Cluster in Prostate Ca
    Joachim Voss; Fiscal Year: 2009
    ..The parent trial will also collect self-report fatigue data at baseline and at the end of treatment in both groups. Gene expression studies will be conducted by the PI at the UW. ..
  27. A Novel Inhibitor of Stat3 for Prostate Cancer Therapy
    Naijie Jing; Fiscal Year: 2009
    ..abstract_text> ..
  28. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2008
    ..In this fashion we hope to establish whether Myc-induced genomic instability merits wider exploration in human neoplasm. [unreadable] [unreadable] [unreadable] [unreadable]..
  29. HU/JHU Head and Neck Cancer Translational Research and *
    Joseph Califano; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  30. Soy Food and Coronary Heart Disease in Women
    Xiao Ou Shu; Fiscal Year: 2008
    ....
  31. Clinical application of multispectral imaging flow cytometry
    Hans Minderman; Fiscal Year: 2008
    ..The aim of the proposed studies is to determine necessary adjustments to this instrument's hardware and analysis software to accurately and efficiently use it in a clinical research setting. ..
  32. Zebrafish Peripheral Sympathetic Nervous System Development and Neuroblastoma
    RANI GEORGE; Fiscal Year: 2008
    ..Insight into the proteins encoded by such modifier genes may lead to the discovery of genes that could serve as novel drug targets for the treatment of older children with advanced disease. [unreadable] [unreadable]..
  33. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009
    ..abstract_text> ..
  34. Modeling Folate, One-Carbon Metabolism & DNA Methylation
    Cornelia Ulrich; Fiscal Year: 2007
    ..We plan to make the model generally available to the research community, and anticipate that it will become a useful tool that can be used as an adjunct to experimental investigations and as an aid to study design. ..
  35. P53 in BBD and Breast Cancer Risk: A Multicenter Cohort
    Thomas Rohan; Fiscal Year: 2006
    ..Furthermore, establishment of our international, multi-disciplinary group will create a unique forum in which to undertake not only this study but also further investigations of the molecular pathogenesis of breast cancer. ..
  36. CHARACTERIZATION AND SORTING OF ZYMOGEN GRANULE PROTEINS
    ANSON LOWE; Fiscal Year: 2004
    ..The model we propose to generate will provide important information on GP2 biology and may also provide potential models for human acute and chronic pancreatic diseases. ..
  37. 2003 Genetic Toxicology Gordon Conference
    Penny Jeggo; Fiscal Year: 2003
    ..We particularly air to obtain funding to support applications from minority groupings and younger scientists. We have already identified a significant participation of women amongst our list of speakers. ..
  38. DNA Methylation in Patients with Non-Hodgkin's Lymphoma
    Victor Levenson; Fiscal Year: 2003
    ..When the assay is optimized for disease detection in patient's plasma we will also address the issue of residual disease detection and monitoring of treatment efficacy. ..
  39. DNA REPAIR GENE POLYMORPHISMS AND BREAST CANCER RISK
    TIMOTHY JORGENSEN; Fiscal Year: 2003
    ..abstract_text> ..
  40. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2003
    ..Finally, we plan to develop a model for integrating information on genetic variability at multiple points in this metabolic pathway. ..
  41. REGULATION OF ANDROGEN RECEPTOR ACTIVITY IN THE PROSTATE
    Michael Garabedian; Fiscal Year: 2003
    ..abstract_text> ..
  42. Workshop On Experimental Models from Bursa of Fabricius
    Paul Neiman; Fiscal Year: 2002
    ..This workshop will serve to stimulate further development and application, and to educate interested young scientists to the opportunities presented. ..
  43. Imprinted PEG3 domain at 19q13.4 and carcinogenesis
    Susan Murphy; Fiscal Year: 2002
    ..These studies will help clarify the role of the human PEG3 isoforms in the control of cellular growth, and may further contribute potential diagnostic and therapeutic targets for ovarian cancer. ..
  44. DNA DAMAGE IN MOUSE TUMORS EVAL BY IR SPECTROSCOPY
    DONALD MALINS; Fiscal Year: 2002
    ..Third, we shall evaluate how two chemotherapeutic drugs with different modes of action affect detectable DNA lesions, using the FT-IR technology, and attempt to correlate this with their activity in tumor formation. ..
  45. GPX1 ENZYME REGULATION BY OXIDATIVE XENOBIOTICS
    Michael Kelner; Fiscal Year: 2002
    ..These studies will provide critical information regarding cellular response to oxidative stress and aid in determining if a common regulatory mechanism exists for GSH-dependent enzymes. ..
  46. BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISK
    Maria Worsham; Fiscal Year: 2001
    ....
  47. TELOMERASE ASSAY FOR OVARIAN CANCER DETECTION
    Louis Dubeau; Fiscal Year: 2004
    ..The potential influence of these agents on the sensitivity of testing for telomerase as a means of detecting ovarian cancer cells will be examined. ..
  48. INHERITED MSH6 MUTATIONS IN DIVERSE COLORECTAL CANCERS
    Sapna Syngal; Fiscal Year: 2004
    ..Evidence that MSH6 is a moderately penetrant, later-onset hereditary colorectal cancer gene would imply the existence of similar genes for other common cancers that await discovery. ..
  49. COORDINATED REGULATION OF ANTIOXIDANT ENZYMES
    Michael Kelner; Fiscal Year: 2005
    ..abstract_text> ..
  50. Biofilm Chemoprevention of Head/Neck Skin Cancer
    Zhi Wang; Fiscal Year: 2005
    ..This is the first study to use polymer biofilm technique for NMSC chemoprevention on head/neck region. We believe that a successful study will greatly benefit patients. ..
  51. The Role of Telomeres and Telomerase in Cancer
    Jerry Shay; Fiscal Year: 2005
    ..abstract_text> ..
  52. DNA Damage as Women Age: Implications for Breast Cancer
    DONALD MALINS; Fiscal Year: 2005
    ....
  53. RAS/BRAF Melanoma Mutations: Precursors, Risk, Prognosis
    Nancy Thomas; Fiscal Year: 2004
    ..This study is also expected to lead to identification of new chemotherapeutic targets and more efficient testing of inhibitors for NRAS and BRAF signaling, which have recently been developed. ..
  54. Systematic Integration POR into Clinical Pathway of HCC
    Myron Schwartz; Fiscal Year: 2006
    ..This program provides a truly remarkable opportunity to make meaningful progress in understanding, preventing and treating HCC, while in the process providing fertile training ground for young physician-scientists. ..
  55. The Effect of Black Cohosh Extract on the Human Breast
    Edward Sauter; Fiscal Year: 2004
    ..The findings should allow us to design a high quality R01 submission involving a larger, randomized study of longer duration which should provide some answers on the potential role of BCE in breast cancer. ..
  56. Molecular Basis of Young Onset Colorectal Cancer
    Lisa Boardman; Fiscal Year: 2006
    ..Following achievement of these goals, I am confident that I will be ready to continue my career as a successful independent investigator committed to colerectal cancer prevention and control. ..
  57. A NOVEL CANCER MODEL--VACCINE ASSOCIATED SARCOMA
    Elizabeth McNiel; Fiscal Year: 2005
    ..I intend to apply the techniques and data acquired from this work to establish a center for animal tumor cytogenetics and genomic to study the role of genetics in the pathogenesis of cancer. ..
  58. A Pilot Trial of Oral Melatonin Supplementation in Breast Cancer Survivors
    Eva Schernhammer; Fiscal Year: 2007
    ..This pilot data could lay the groundwork for a large scale trial to assess the chemopreventive potential of melatonin in women, both with and without a personal history of breast cancer. [unreadable] [unreadable] [unreadable]..
  59. Effects of Light at Night on Circadian System in Nurses
    Eva Schernhammer; Fiscal Year: 2008
    ..abstract_text> ..
  60. Clock Genes, Night Work, and Breast Cancer Risk
    Eva Schernhammer; Fiscal Year: 2008
    ..The results from this study could help identify individuals who are more susceptible to night work than others, based on their genetic profile. ..
  61. Anti-Leukemic Activity of the Novel Triterpeniod CDDO
    Michael Andreeff; Fiscal Year: 2004
    ..The long-term goal of our proposed mechanistic and efficacy studies is to determine the potential of CDDO as a novel anti-leukemia and anti-tumor agent. ..
  62. LETHAL MUTAGENESIS OF HIV BY DEOXYNUCLEOSIDE ANALOGS
    LAWRENCE LOEB; Fiscal Year: 2002
    ....
  63. Luminal Lipid Exposure, Genetics and Colon Cancer Risk
    Ikuko Kato; Fiscal Year: 2006
    ..In addition, accumulated dietary data and biological specimens will serve as an important resource for future research on other nutrient-gene interactions. ..
  64. Whole genome amplification and DNA pooling strategies
    Immaculata DeVivo; Fiscal Year: 2004
    ..Results from the pooling experiments will determine whether this method may be sensitive enough for use in nested case-control studies where a small difference in allele frequency is expected. ..
  65. Tumor suppressor adenomatous polyposis coli and breast carcinogenesis
    Satya Narayan; Fiscal Year: 2007
    ....
  66. CHROMOSOME ALTERATIONS IN BARRETT'S ESOPHAGUS
    THOMAS PAULSON; Fiscal Year: 2005
    ..The results from these analyses will be of interest to both clinical and basic researchers in studying EA and other cancers. ..
  67. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 2001
    ..Therefore, novel therapeutic strategies may emerge with respect to potential new targets for chemotherapeutic intervention in colon cancer. ..
  68. CORI: Consortium Expansion and Database Enhancement
    David Lieberman; Fiscal Year: 2004
    ....
  69. Screening for colortectal cancer in an Asian Community Center
    David Lieberman; Fiscal Year: 2008
    ..This is a new paradigm for screening, which takes advantage of the trust and cultural awareness that exists at the community center and does not rely on the primary care provider. [unreadable] [unreadable] [unreadable] [unreadable]..
  70. Environmental Mutagen Society, 34th Annual Meeting
    LAWRENCE LOEB; Fiscal Year: 2003
    ..Awards will be made to US speakers whose major area of interest is in carcinogenesis. ..