thyroid hormones

Summary

Summary: Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.

Top Publications

  1. ncbi Physiological and molecular basis of thyroid hormone action
    P M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Physiol Rev 81:1097-142. 2001
  2. pmc Molecular aspects of thyroid hormone actions
    Sheue yann Cheng
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Rev 31:139-70. 2010
  3. ncbi Trans-placental transfer of thirteen perfluorinated compounds and relations with fetal thyroid hormones
    Sunmi Kim
    School of Public Health, Seoul National University, Seoul 151 742, Korea
    Environ Sci Technol 45:7465-72. 2011
  4. ncbi Neurodevelopmental and neurophysiological actions of thyroid hormone
    G R Williams
    Molecular Endocrinology Group, Division of Medicine and MRC Clinical Sciences Centre, Imperial College, London, UK
    J Neuroendocrinol 20:784-94. 2008
  5. ncbi Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer
    Barbara Chaneton
    Cancer Research UK, The Beatson Institute for Cancer Research, Switchback Road, Glasgow, UK
    Trends Biochem Sci 37:309-16. 2012
  6. pmc Polybrominated diphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy
    Jonathan Chevrier
    Center for Children s Environmental Health Research, School of Public Health, University of California Berkeley, Berkeley, California 94704 7392, USA
    Environ Health Perspect 118:1444-9. 2010
  7. ncbi Thyroid hormone as a determinant of metabolic and contractile phenotype of skeletal muscle
    Warner S Simonides
    Laboratory for Physiology, Institute for Cardiovascular Research VU University Medical Center, Amsterdam, The Netherlands
    Thyroid 18:205-16. 2008
  8. ncbi Cell and molecular biology of transthyretin and thyroid hormones
    Samantha J Richardson
    UMR CNRS 5166, Evolution des Regulations Endocriniennes, Museum national d histoire naturelle, 75231 Paris, France
    Int Rev Cytol 258:137-93. 2007
  9. pmc Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age
    Elise Roze
    Division of Neonatology, Beatrix Children s Hospital, University Medical Center Groningen, The Netherlands
    Environ Health Perspect 117:1953-8. 2009
  10. ncbi Thyroid hormone homeostasis and action in the type 2 deiodinase-deficient rodent brain during development
    Valerie Anne Galton
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, New Hampshire 03756, USA
    Endocrinology 148:3080-8. 2007

Detail Information

Publications390 found, 100 shown here

  1. ncbi Physiological and molecular basis of thyroid hormone action
    P M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Physiol Rev 81:1097-142. 2001
    b>Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and physiological function of virtually all tissues...
  2. pmc Molecular aspects of thyroid hormone actions
    Sheue yann Cheng
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Rev 31:139-70. 2010
    ..The critical role of TRs is evident in that mutations of the TRbeta gene cause resistance to thyroid hormones to exhibit an array of symptoms due to decreasing the sensitivity of target tissues to T(3)...
  3. ncbi Trans-placental transfer of thirteen perfluorinated compounds and relations with fetal thyroid hormones
    Sunmi Kim
    School of Public Health, Seoul National University, Seoul 151 742, Korea
    Environ Sci Technol 45:7465-72. 2011
    ..the results of animal studies have shown that perfluorinated compounds (PFCs) can modulate concentrations of thyroid hormones in blood, limited information is available on relationships between concentrations of PFCs in human blood ..
  4. ncbi Neurodevelopmental and neurophysiological actions of thyroid hormone
    G R Williams
    Molecular Endocrinology Group, Division of Medicine and MRC Clinical Sciences Centre, Imperial College, London, UK
    J Neuroendocrinol 20:784-94. 2008
    For over 100 years, thyroid hormones have been known to be essential for neonatal neurodevelopment but whether they are required by the foetal brain remains a matter of controversy...
  5. ncbi Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer
    Barbara Chaneton
    Cancer Research UK, The Beatson Institute for Cancer Research, Switchback Road, Glasgow, UK
    Trends Biochem Sci 37:309-16. 2012
    ..In light of this knowledge, the potential therapeutic implications and strategies are critically discussed...
  6. pmc Polybrominated diphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy
    Jonathan Chevrier
    Center for Children s Environmental Health Research, School of Public Health, University of California Berkeley, Berkeley, California 94704 7392, USA
    Environ Health Perspect 118:1444-9. 2010
    ..Although thyroid hormone (TH) of maternal origin plays an essential role in normal fetal brain development, there is a paucity of human data regarding associations between exposure to PBDEs and maternal TH levels during pregnancy...
  7. ncbi Thyroid hormone as a determinant of metabolic and contractile phenotype of skeletal muscle
    Warner S Simonides
    Laboratory for Physiology, Institute for Cardiovascular Research VU University Medical Center, Amsterdam, The Netherlands
    Thyroid 18:205-16. 2008
    ..This review addresses the mechanisms by which TH may modulate fiber gene expression and discusses some of the implications of the TH-regulated changes in metabolic and contractile phenotype of skeletal muscle...
  8. ncbi Cell and molecular biology of transthyretin and thyroid hormones
    Samantha J Richardson
    UMR CNRS 5166, Evolution des Regulations Endocriniennes, Museum national d histoire naturelle, 75231 Paris, France
    Int Rev Cytol 258:137-93. 2007
    ..This review concentrates on TTR and its thyroid hormone binding, in development and during evolution, and summarizes what is currently known about TLPs and the role of TTR in diseases affecting the brain...
  9. pmc Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age
    Elise Roze
    Division of Neonatology, Beatrix Children s Hospital, University Medical Center Groningen, The Netherlands
    Environ Health Perspect 117:1953-8. 2009
    ..Organohalogen compounds (OHCs) are known to have neurotoxic effects on the developing brain...
  10. ncbi Thyroid hormone homeostasis and action in the type 2 deiodinase-deficient rodent brain during development
    Valerie Anne Galton
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, New Hampshire 03756, USA
    Endocrinology 148:3080-8. 2007
    ..This view is inadequate to explain the findings presented herein, and it is suggested that important compensatory mechanisms must be in play in the brain to minimize functional abnormalities in the absence of the D2...
  11. ncbi Minireview: thyroid hormone transporters: the knowns and the unknowns
    W Edward Visser
    Erasmus University Medical Center, Molewaterplein 50, Rotterdam, The Netherlands
    Mol Endocrinol 25:1-14. 2011
    ..The prospects of identifying other transporters and transporter-based syndromes promise an exciting future in the TH transporter field...
  12. pmc Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines
    Ruey Nan Chen
    Department of Biochemistry, Chang Gung University, 259 Wen hwa 1 Road, Taoyuan 333, Taiwan, Republic of China
    Endocrinology 149:3817-31. 2008
    ..Thus, T(3) regulates furin gene expression via a novel mechanism or in cooperation with TGF-beta to enhance tumor metastasis in vitro and in vivo...
  13. ncbi Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
    Edith C H Friesema
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3015 GE, The Netherlands
    J Biol Chem 278:40128-35. 2003
    ..Immunohistochemistry showed high expression in liver, kidney, brain, and heart. In conclusion, we have identified MCT8 as a very active and specific thyroid hormone transporter...
  14. ncbi Impact of monocarboxylate transporter-8 deficiency on the hypothalamus-pituitary-thyroid axis in mice
    Marija Trajkovic-Arsic
    Leibniz Institute for Age Research Fritz Lipmann Institute e V, Beutenbergstr 11, D 07745 Jena, Germany
    Endocrinology 151:5053-62. 2010
    ....
  15. ncbi Deiodinases: the balance of thyroid hormone: local impact of thyroid hormone inactivation
    Monica Dentice
    Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Endocrinol 209:273-82. 2011
    ..It summarizes the intriguing evidence that D3 plays a pivotal role in defining local TH concentration in the developing fetus and in several conditions in adult life...
  16. ncbi Thermogenic mechanisms and their hormonal regulation
    J Enrique Silva
    Baystate Medical Education and Research Foundation, Department of Medicine, Division of Endocrinology, Baystate Medical Center, Tufts University Medical School, Springfield, Massachusetts, USA
    Physiol Rev 86:435-64. 2006
    ..Thermogenesis has a very high energy cost. Cold adaptation and food availability may have been conflicting selection pressures accounting for the variability of thermogenesis in humans...
  17. ncbi Action of thyroid hormone in brain
    J Bernal
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientfficas, Universidad Autonoma de Madrid, Spain
    J Endocrinol Invest 25:268-88. 2002
    ..The resolution of this paradox is essential to understand the role of thyroid hormone and its receptors in brain development and function...
  18. ncbi Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice
    Alexandra M Dumitrescu
    Department of Medicine, University of Chicago, MC 3090, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA
    Endocrinology 147:4036-43. 2006
    ..We conclude that cell-specific differences in intracellular TH content due to differences in contribution of the various TH transporters are responsible for the unusual clinical presentation of this defect, in contrast to TH deficiency...
  19. pmc Birth delivery mode modifies the associations between prenatal polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) and neonatal thyroid hormone levels
    Julie B Herbstman
    Columbia Center for Children s Environmental Health, Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, New York 10032, USA
    Environ Health Perspect 116:1376-82. 2008
    ..Developing infants may be especially sensitive to hormone disruption from chemicals including polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs)...
  20. pmc Associations between polybrominated diphenyl ether (PBDE) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Health Perspect 119:1454-9. 2011
    ..Polybrominated diphenyl ethers (PBDEs) are chemical additives used as flame retardants in commercial products. PBDEs are bioaccumulative and persistent and have been linked to several adverse health outcomes...
  21. ncbi Thyroid hormone action at the cellular, genomic and target gene levels
    Paul M Yen
    Department of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue Rm B114, Baltimore, MD, USA
    Mol Cell Endocrinol 246:121-7. 2006
    ....
  22. pmc Minireview: Defining the roles of the iodothyronine deiodinases: current concepts and challenges
    Donald L St Germain
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Endocrinology 150:1097-107. 2009
    As is typical of other hormone systems, the actions of the thyroid hormones (TH) differ from tissue to tissue depending upon a number of variables...
  23. ncbi Role of thyroid hormone during early brain development
    Gabriella Morreale de Escobar
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas CSIC y Universidad Autonoma de Madrid UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    Eur J Endocrinol 151:U25-37. 2004
    ....
  24. pmc Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats
    Warner S Simonides
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Invest 118:975-83. 2008
    ..These results suggest a mechanism of metabolic regulation during hypoxic-ischemic injury in which HIF-1 reduces local thyroid hormone signaling through induction of D3...
  25. pmc Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice
    Elisavet Vasilopoulou
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e65402. 2013
    ..In mice, Mct8 knockout has subtle effects upon fetoplacental growth and does not significantly affect placental cell viability probably due to compensatory mechanisms in vivo...
  26. pmc PPARγ contributes to PKM2 and HK2 expression in fatty liver
    Ganna Panasyuk
    INSERM, U845, Paris 75015, France
    Nat Commun 3:672. 2012
    ....
  27. ncbi Thyroid physiology
    Nikolaos Stathatos
    Department of Medicine, Thyroid Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Med Clin North Am 96:165-73. 2012
    ..Such discoveries have significantly improved our understanding of thyroid physiology. As a result, new diagnostic and therapeutic approaches for the management of thyroid disorders are now available or in development...
  28. ncbi General background on the hypothalamic-pituitary-thyroid (HPT) axis
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 37:11-53. 2007
    ..For example, it describes the thyroid gland, its structure and development, how thyroid hormones are synthesized and regulated, the role of iodine in thyroid hormone synthesis, and finally how the thyroid ..
  29. ncbi Thyroid hormones and their effects: a new perspective
    A J Hulbert
    Metabolic Research Centre and Department of Biological Sciences, University of Wollongong, NSW, Australia
    Biol Rev Camb Philos Soc 75:519-631. 2000
    The thyroid hormones are very hydrophobic and those that exhibit biological activity are 3',5',3,5-L-tetraiodothyronine (T4), 3',5,3-L-triiodothyronine (T3), 3',5',3-L-triiodothyronine (rT3) and 3,5',-L-diiothyronine (3,5-T2)...
  30. ncbi The pathophysiological consequences of thyroid hormone transporter deficiencies: Insights from mouse models
    Heike Heuer
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    Biochim Biophys Acta 1830:3974-8. 2013
    ..Most surprisingly, Mct8 ko mice do not show any neurological symptoms but fully replicate the abnormal serum thyroid state...
  31. ncbi Serum concentrations of major perfluorinated compounds among the general population in Korea: dietary sources and potential impact on thyroid hormones
    Kyunghee Ji
    School of Public Health, Seoul National University, Seoul, 151 742, Republic of Korea
    Environ Int 45:78-85. 2012
    ..The result of this study will provide information useful for developing public health and safety management measures for PFCs...
  32. pmc A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism
    J H Duncan Bassett
    Molecular Endocrinology Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, United Kingdom
    Mol Endocrinol 22:501-12. 2008
    ..of two mouse models of congenital hypothyroidism in which the normal reciprocal relationship between thyroid hormones and TSH was intact or disrupted...
  33. ncbi Thyroid hormone receptor β mediates thyroid hormone effects on bone remodeling and bone mass
    Laurent Emmanuel Monfoulet
    INSERM, U577, and University Victor Segalen, Bordeaux, France
    J Bone Miner Res 26:2036-44. 2011
    ..These data shed new light on the respective roles of TRs in the control of bone metabolism by TH...
  34. pmc The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans
    Anders Berkenstam
    Karo Bio AB, Novum Research Park, S 141 57 Huddinge, Sweden
    Proc Natl Acad Sci U S A 105:663-7. 2008
    ..Thus, selective thyromimetics deserve further study as agents to treat dyslipidemia and other risk factors for atherosclerosis...
  35. ncbi Effect of supplementation of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats
    S S Awaisheh
    Department of Food Science, Al Balqa Applied University, 19117, Salt, Jordan
    J Dairy Sci 96:9-15. 2013
    ..of probiotics and phytosterols alone or in combination on serum and hepatic lipid profiles and thyroid hormones of hypercholesterolemic rats...
  36. ncbi Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population
    Nils Knudsen
    Endocrine Unit, Medical Clinic I, Bispebjerg Hospital, Copenhagen, Denmark
    J Clin Endocrinol Metab 90:4019-24. 2005
    ..Few data have been presented regarding an association between variations in thyroid function seen in the general population and body weight...
  37. ncbi Maternal thyroid hormones early in pregnancy and fetal brain development
    Gabriella Morreale de Escobar
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas CSIC y Universidad Autonoma de Madrid UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    Best Pract Res Clin Endocrinol Metab 18:225-48. 2004
    During the last few decades our understanding of the possible role of thyroid hormones during brain development has increased and contributed to resolve previously discordant hypotheses, although much remains to be clarified...
  38. pmc Thyroxine is a potential endogenous antagonist of macrophage migration inhibitory factor (MIF) activity
    Yousef Al-Abed
    Centers for Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 108:8224-7. 2011
    Abnormally low plasma concentrations of thyroid hormones during sepsis often occur in the absence of thyroidal illness; however, the mechanisms involved in the "euthyroid sick syndrome" remain poorly understood...
  39. ncbi Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie und Endokrinologisches Forschungszentrum EnForCé, Charite, Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Toxicology 205:95-102. 2004
    ....
  40. ncbi Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4alpha
    David M Selva
    Child and Family Research Institute, British Columbia, Canada
    J Mol Endocrinol 43:19-27. 2009
    b>Thyroid hormones increase hepatic sex hormone-binding globulin (SHBG) production, which is also regulated by hepatocyte nuclear factor-4alpha (HNF-4alpha) in response to changes in the metabolic state of the liver...
  41. ncbi Plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones
    Alfonso Troisi
    Department of Neurosciences, University of Rome Tor Vergata, Rome, Italy
    Neuroendocrinology 81:259-66. 2005
    ..between plasma ghrelin concentrations, eating patterns, and circulating concentrations of cortisol and thyroid hormones in women with anorexia nervosa, bulimia nervosa, and binge-eating disorder...
  42. ncbi Effects of low mercury vapour exposure on the thyroid function in chloralkali workers
    D G Ellingsen
    National Institute of Occupational Health, PO Box 8149 Dep, N 0033 Oslo, Norway
    J Appl Toxicol 20:483-9. 2000
    ..The study could indicate a slight effect of low mercury vapour exposure on the function of the enzyme type I iodothyronine deiodinase, possibly modified by comparatively low urinary iodine concentrations...
  43. ncbi Effects of temperature on photoperiodically induced reproductive development, circulating plasma luteinizing hormone and thyroid hormones, body mass, fat deposition and molt in mountain white-crowned sparrows, Zonotrichia leucophrys oriantha
    John C Wingfield
    Department of Zoology, Box 351800, University of Washington, Seattle, WA 98195, USA
    Gen Comp Endocrinol 131:143-58. 2003
    ..on short days (9L 15D) had no effect on body mass, fat, or plasma levels of luteinizing hormone (LH) and thyroid hormones. Curiously there was no effect of temperature on photoperiodically induced rises in LH in either sex despite ..
  44. ncbi Thyroid hormone and the cardiovascular system
    Sara Danzi
    Department of Biological Sciences and Geology, Queensborough Community College, Bayside, NY 11364, USA
    Med Clin North Am 96:257-68. 2012
    ..The characteristic changes in cardiovascular hemodynamics and metabolism that accompany thyroid disease states can then be best understood at the cellular level...
  45. ncbi Distinct modulatory roles for thyroid hormone receptors TRalpha and TRbeta in SREBP1-activated ABCD2 expression
    Isabelle Weinhofer
    Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Eur J Cell Biol 87:933-45. 2008
    ..These findings show that TRalpha and TRbeta differentially modulate SREBP1-activated ABCD2 expression at overlapping SRE/DR-4 elements, suggesting a novel mode of cross-talk between TR and SREBP in gene regulation...
  46. ncbi Subclinical thyroid disease
    David S Cooper
    Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Lancet 379:1142-54. 2012
    ..Large-scale randomised trials are urgently needed to inform how to best care for individuals with subclinical thyroid disease...
  47. ncbi Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heart
    M Lopez-Torres
    Department of Animal Biology II Animal Physiology, Faculty of Biology, Complutense University, 28040, Madrid, Spain
    Mol Cell Endocrinol 168:127-34. 2000
    ..The lack of increase in H(2)O(2) production per unit of mitochondrial protein will protect mitochondria themselves against self-inflicted damage during hyperthyroidism...
  48. pmc Signaling mechanisms in thyroid hormone-induced cardiac hypertrophy
    Kaie Ojamaa
    The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Vascul Pharmacol 52:113-9. 2010
    ..The present review examines these molecular mechanisms and intracellular signaling pathways activated in thyroid hormone-induced cardiac hypertrophy that support its therapeutic potential in the treatment of heart disease...
  49. ncbi Structure and function of the type 3 deiodinase gene
    Arturo Hernandez
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Thyroid 15:865-74. 2005
    b>Thyroid hormones (TH) are essential for normal growth and development in vertebrates, and are important for the maintenance of normal metabolic activity in most tissues of the body...
  50. ncbi Iodine deficiency and brain development in the first half of pregnancy
    Gabriella Morreale de Escobar
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC and UAM, Calle Arturo Duperier, 4, 28029 Madrid, Spain
    Public Health Nutr 10:1554-70. 2007
    ....
  51. ncbi Adaptive activation of thyroid hormone and energy expenditure
    Antonio C Bianco
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, HIM Bldg 643, Massachusetts, Boston, MA 02115, USA
    Biosci Rep 25:191-208. 2005
    ..This article reviews current biological knowledge about D2 and adaptive T3 production and their roles in energy expenditure...
  52. ncbi Long-day suppressed expression of type 2 deiodinase gene in the mediobasal hypothalamus of the Saanen goat, a short-day breeder: implication for seasonal window of thyroid hormone action on reproductive neuroendocrine axis
    Shinobu Yasuo
    Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Endocrinology 147:432-40. 2006
    ..However, the molecular basis for seasonal reproduction in short-day breeders remains unclear. Because thyroid hormones are also known to be involved in short-day breeders, we examined the effect of an artificial long-day ..
  53. ncbi The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations
    Heike Heuer
    Institute of Molecular Biotechnology, Beutenbergstrasse 11, D 07745 Jena, Germany
    Endocrinology 146:1701-6. 2005
    ....
  54. ncbi Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones
    Luigi Fontana
    Washington University School of Medicine, 4566 Scott Avenue, Campus Box 8113, St Louis, MO 63110, USA
    J Clin Endocrinol Metab 91:3232-5. 2006
    ..Caloric restriction (CR) retards aging in mammals. It has been hypothesized that a reduction in T(3) hormone may increase life span by conserving energy and reducing free-radical production...
  55. ncbi Influence of thyroid hormones on maturation of rat cerebellar astrocytes
    Jimena Manzano
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    Int J Dev Neurosci 25:171-9. 2007
    ..Astrocytes express thyroid hormone receptor alpha and beta subtypes suggesting that astrocytes are direct target cells of thyroid hormones.
  56. ncbi Triiodothyronine levels in athyreotic individuals during levothyroxine therapy
    Jacqueline Jonklaas
    Division of Endocrinology, Georgetown University Medical Center, Washington, DC, USA
    JAMA 299:769-77. 2008
    ..However, trials evaluating therapy with combined LT4 and T3 have failed to demonstrate any consistent advantage of combination therapy...
  57. ncbi Translational implications of nongenomic actions of thyroid hormone initiated at its integrin receptor
    Paul J Davis
    Signal Transduction Laboratory, Ordway Research Institute, Albany, NY 12208, USA
    Am J Physiol Endocrinol Metab 297:E1238-46. 2009
    ..Discussed here are the implications of translating these nongenomic mechanisms of thyroid hormone analogs into clinical cancer cell biology, tumor-related angiogenesis, and modulation of angiogenesis that is not related to cancer...
  58. ncbi Establishment of reference range for thyroid hormones in normal pregnant Indian women
    R K Marwaha
    Division of Endocrinology and Thyroid Research, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
    BJOG 115:602-6. 2008
    ..While India has become iodine sufficient after two decades of salt iodisation, there is no normative data for thyroid function from healthy pregnant women of this country...
  59. ncbi Medicinal values of fruit peels from Citrus sinensis, Punica granatum, and Musa paradisiaca with respect to alterations in tissue lipid peroxidation and serum concentration of glucose, insulin, and thyroid hormones
    Hamendra Singh Parmar
    School of Life Sciences, Devi Ahilya University, Indore, MP, India
    J Med Food 11:376-81. 2008
    ..were investigated for their effects on tissue lipid peroxidation (LPO) and on the concentration of thyroid hormones, insulin, and glucose in male rats...
  60. ncbi POP levels in breast milk and maternal serum and thyroid hormone levels in mother-child pairs from Uppsala, Sweden
    P O Darnerud
    National Food Administration, PO Box 622, 751 26 Uppsala, Sweden
    Environ Int 36:180-7. 2010
    In experimental studies, it has frequently been observed that the homeostasis of thyroid hormones (THs) is affected by exposure to persistent organic pollutants (POPs), such as dioxins and PCBs...
  61. pmc Rapid nongenomic actions of thyroid hormone
    Yukio Hiroi
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:14104-9. 2006
    ....
  62. ncbi Thyroid hormone and uncoupling proteins
    A Lanni
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100, Caserta, Italy
    FEBS Lett 543:5-10. 2003
    ....
  63. ncbi Vascular and renal function in experimental thyroid disorders
    Felix Vargas
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Granada, E 18012 Granada, Spain
    Eur J Endocrinol 154:197-212. 2006
    This review focuses on the effects of thyroid hormones in vascular and renal systems...
  64. pmc Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes
    Mark D Miller
    Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, California 94612, USA
    Environ Health Perspect 117:1033-41. 2009
    ..between exposure to specific environmental chemicals and perturbations in levels of critically important thyroid hormones (THs)...
  65. pmc Stepping backward to improve assessment of PCB congener toxicities
    L G Hansen
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    Environ Health Perspect 106:171-89. 1998
    ..A more comprehensive list of PCB congeners is proposed that would provide more adequate data upon which to base associations with adverse outcomes...
  66. pmc Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8
    Anita Kinne
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    J Biol Chem 285:28054-63. 2010
    ..The MCT8 model allows us to rationalize potential interactions of amino acids including those mutated in patients with Allan-Herndon-Dudley syndrome...
  67. ncbi The Colorado thyroid disease prevalence study
    G J Canaris
    Department of Medicine, University of Nebraska Medical Center, Omaha 68198 3331, USA
    Arch Intern Med 160:526-34. 2000
    ..Systemic effects of abnormal thyroid function have not been fully delineated, particularly in cases of mild thyroid failure. Also, the relationship between traditional hypothyroid symptoms and biochemical thyroid function is unclear...
  68. pmc Thyroid hormone action: a binding contract
    Mitchell A Lazar
    University of Pennsylvania School of Medicine, 611 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Invest 112:497-9. 2003
    b>Thyroid hormones are critical for differentiation, growth, and metabolism...
  69. pmc Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa machi Maebashi, Gunma, Japan
    Endocrinology 150:3417-24. 2009
    ..This novel observation indicates that TH fine-tunes hepatic lipogenesis via regulating SREBP-1c and ChREBP gene expression reciprocally...
  70. pmc A dominant-negative thyroid hormone receptor blocks amphibian metamorphosis by retaining corepressors at target genes
    Daniel R Buchholz
    Unit on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, National Institute for Child Health and Human Development, Bethesda, Maryland 20892 5431, USA
    Mol Cell Biol 23:6750-8. 2003
    ....
  71. pmc Epithelial-connective tissue interactions induced by thyroid hormone receptor are essential for adult stem cell development in the Xenopus laevis intestine
    Takashi Hasebe
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Stem Cells 29:154-61. 2011
    ....
  72. pmc Cardiac hypertrophy and thyroid hormone signaling
    Wolfgang Dillmann
    University of California, San Diego, USA
    Heart Fail Rev 15:125-32. 2010
    ..The failing heart may develop a "hypothyroid" status contributing to diminished cardiac contractile function...
  73. pmc Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes
    Monica Dentice
    Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, 80131 Naples, Italy, and Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:14466-71. 2007
    ..This previously unrecognized functional cross-talk between Shh/Gli2 and thyroid hormone in keratinocytes is a pathway by which Shh produces its proliferative effects and offers a potential therapeutic approach to BCC...
  74. pmc Subclinical thyroid disorders and cognitive performance among adolescents in the United States
    Tiejian Wu
    Department of Public Health, East Tennessee State University, Johnson City, TN 37614, USA
    BMC Pediatr 6:12. 2006
    ..The purpose of the study was to examine the relationships between the status of subclinical thyroid conditions and cognition among adolescents in the United States...
  75. ncbi Dual mechanisms governing muscle cell death in tadpole tail during amphibian metamorphosis
    Keisuke Nakajima
    Division of Embryology and Genetics, Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, Higashihiroshima, Japan
    Dev Dyn 227:246-55. 2003
    ....
  76. ncbi The Duisburg birth cohort study: influence of the prenatal exposure to PCDD/Fs and dioxin-like PCBs on thyroid hormone status in newborns and neurodevelopment of infants until the age of 24 months
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstr 150, 44801 Bochum, Germany
    Mutat Res 659:83-92. 2008
    ..6-52.4 pg/glipid base (median: 19.7 pg/glipid base). Multiple regression analysis showed no decrease of thyroid hormones related to WHO 2005 TEQ in blood and milk of mothers and their newborns...
  77. pmc Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells
    Beatriz C G Freitas
    Laboratory of Molecular Endocrinology, Division of Endocrinology, Department of Medicine, Federal University of Sao Paulo, Sao Paulo SP, Brazil
    J Clin Invest 120:2206-17. 2010
    ....
  78. pmc Multigenic control of thyroid hormone functions in the nervous system
    Jacques Nunez
    National Institutes of Health, NIDDK, Clinical Endocrinology Branch, Bethesda, MD 20892 1772, USA
    Mol Cell Endocrinol 287:1-12. 2008
    ..Overall, TH coordinates this variety of events in both central and sensory systems to promote the function of the nervous system as a complete entity...
  79. ncbi Thyroid hormone transport in and out of cells
    W Edward Visser
    Department of Internal Medicine, Erasmus University Medical Centre, Dr Molewaterplein 50, Rotterdam, The Netherlands
    Trends Endocrinol Metab 19:50-6. 2008
    ..The exact pathophysiological mechanisms in MCT8 patients remain to be elucidated fully. Future research will probably identify novel TH transporters and disorders based on TH transporter defects...
  80. ncbi Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism
    Jose C Moreno
    Department of Pediatric Endocrinology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam
    N Engl J Med 347:95-102. 2002
    ....
  81. ncbi The effect of freezing, thawing, and short- and long-term storage on serum thyrotropin, thyroid hormones, and thyroid autoantibodies: implications for analyzing samples stored in serum banks
    Tuija Männistö
    Clin Chem 53:1986-7. 2007
  82. ncbi Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism
    Maria Izabel Chiamolera
    Department of Pediatrics, Division of Metabolism, Johns Hopkins University Medical School, Baltimore, Maryland 21287, USA
    Endocrinology 150:1091-6. 2009
    ..These results are summarized in the review...
  83. pmc Thyroid hormone may regulate mRNA abundance in liver by acting on microRNAs
    Hongyan Dong
    Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, Ontario, Canada
    PLoS ONE 5:e12136. 2010
    ..However, very little is known about the role of miRNAs in mediating the action of thyroid hormones (TH)...
  84. ncbi Local activation and inactivation of thyroid hormones: the deiodinase family
    J Kohrle
    Abteilung für Molekulare Innere Medizin und Klinische Forschergruppe der Medizinischen Poliklinik der Universität Würzburg, Germany
    Mol Cell Endocrinol 151:103-19. 1999
    ..Local thyroid hormone availability is further modulated by conjugation reactions of the phenolic 4'-OH-group of iodothyronines, which also inactivate the thyroid hormones.
  85. ncbi Iodine deficiency
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Schmelzbergstrasse 7, LFV E19, CH 8092 Zurich, Switzerland
    Endocr Rev 30:376-408. 2009
    ....
  86. ncbi XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development
    M Brannon
    Department of Biochemistry, Howard Hughes Medical Institute, Center for Developmental Biology, University of Washington School of Medicine, Seattle, Washington 98195 7350, USA
    Development 126:3159-70. 1999
    ..Our data support a role for XCtBP as a co-repressor throughout Xenopus development and indicate that XCtBP/G4A will be a useful tool in determining how XCtBP functions in various developmental processes...
  87. ncbi Avian thyroid development and adaptive plasticity
    F M Anne McNabb
    Department of Biological Sciences, Virginia Tech, Blacksburg, 24061 0406, USA
    Gen Comp Endocrinol 147:93-101. 2006
    ..Our knowledge is greatest for precocial galliform birds although the organismal picture of thyroid development has been investigated in several altricial avian species...
  88. ncbi Effects of thyroid hormone on the cardiovascular system
    Serafino Fazio
    Department of Clinical Medicine and Cardiovascular Sciences, University of Naples Federico II School of Medicine, 80131, Naples, Italy
    Recent Prog Horm Res 59:31-50. 2004
    ....
  89. pmc Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo
    Nobuyuki Shibusawa
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC1027, Chicago, Illinois 60637, USA
    J Clin Invest 112:588-97. 2003
    ..Inner ear development, although not completely normal, can occur in the absence of TR DNA-binding, suggesting that an alternative and perhaps novel thyroid hormone-signaling pathway may mediate these effects...
  90. ncbi Thyroid hormones states and brain development interactions
    Osama M Ahmed
    Zoology Department, Faculty of Science, Beni Suef University, Egypt
    Int J Dev Neurosci 26:147-209. 2008
    The action of thyroid hormones (THs) in the brain is strictly regulated, since these hormones play a crucial role in the development and physiological functioning of the central nervous system (CNS)...
  91. pmc Deletion of the thyroid hormone receptor alpha 1 prevents the structural alterations of the cerebellum induced by hypothyroidism
    Beatriz Morte
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 99:3985-9. 2002
    ..Our data indicate that thyroid hormone has a permissive effect on cerebellar granule cell migration through derepression by the TRalpha1 isoform...
  92. ncbi The role of thyroid hormone in blood pressure homeostasis: evidence from short-term hypothyroidism in humans
    Enza Fommei
    National Council of Research, University of Pisa, Italy
    J Clin Endocrinol Metab 87:1996-2000. 2002
    ..02, P < 0.036, and P < 0.024, respectively). In conclusion, our data show that thyroid hormones participate in the control of systemic arterial blood pressure homeostasis in normotensive subjects...
  93. ncbi Selective thyroid hormone receptor modulators
    Hikari A I Yoshihara
    Departments of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143 2280, USA
    Curr Top Med Chem 3:1601-16. 2003
    ..This review will provide an introduction to thyroid hormone biology, and will discuss the chemistry and pharmacology of the first generation STRMs...
  94. ncbi Impact of flavonoids on thyroid function
    Maria Carolina de Souza Dos Santos
    Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, RJ, Brazil
    Food Chem Toxicol 49:2495-502. 2011
    ..Experimental data have shown that many flavonoids could inhibit thyroperoxidase activity, decreasing thyroid hormones levels thus increasing TSH and causing goiter...
  95. ncbi Thyroid hormone signaling and homeostasis during aging
    J Bowers
    Museum national d histoire naturelle, Laboratoire de Physiologie Generale et Comparee, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 7221, 75231 Paris Cedex 5, France
    Endocr Rev 34:556-89. 2013
    ..We propose the hypothesis that constraints on TH signaling at certain life stages, notably during maturity, are advantageous for optimal aging. ..
  96. ncbi Upregulation of Slc39a10 gene expression in response to thyroid hormones in intestine and kidney
    Kaler Pawan
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Biochim Biophys Acta 1769:117-23. 2007
    ..Present study documents the impact of thyroid hormones on the expression of Zip10 encoded by Slc39a10 gene in rat model of hypo and hyperthyroidism...
  97. ncbi Regulation of fibroblast growth factor receptor-1 (FGFR1) by thyroid hormone: identification of a thyroid hormone response element in the murine Fgfr1 promoter
    Patrick J O'Shea
    Gene Regulation Section, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Endocrinology 148:5966-76. 2007
    ..Thus, in addition to indirect regulation of FGFR1 expression by T(3) reported previously, T(3) also activates the Fgfr1 promoter directly via a thyroid hormone response element located at positions -279/-264...
  98. pmc Identification of thyroid hormone receptor binding sites and target genes using ChIP-on-chip in developing mouse cerebellum
    Hongyan Dong
    Hazard Identification Division, EHSRB, Health Canada, Ottawa, Ontario, Canada
    PLoS ONE 4:e4610. 2009
    ..These findings provide mechanistic insight into impaired neurodevelopment resulting from TH deficiency and a rich bioinformatics resource for developing a better understanding of TR binding...
  99. ncbi The brain dopaminergic system as an important center regulating liver cytochrome P450 in the rat
    Jacek Wojcikowski
    Department of Pharmacokinetics and Drug Metabolism, Institute of Pharmacology, Krakow, Poland
    Expert Opin Drug Metab Toxicol 5:631-45. 2009
    ....
  100. ncbi Molecular characterization of myocardial fibrosis during hypothyroidism: evidence for negative regulation of the pro-alpha1(I) collagen gene expression by thyroid hormone receptor
    W J Chen
    First Cardiovascular Division, Chang Gung Memorial Hospital, Taiwan
    Mol Cell Endocrinol 162:45-55. 2000
    ..The TR-DNA binding assays demonstrated binding of the human TRbeta1 to a fragment containing a proposed TRE located between position -35 and +115 in the 5'-flanking region of the rat pro-alphal(I) collagen gene...
  101. ncbi Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms
    Outi M Hyyti
    Division of Cardiology, Department of Pediatrics, University of Washington, Seattle, USA
    Am J Physiol Endocrinol Metab 290:E372-9. 2006
    ..T3 also moderates forward glutamine flux, possibly by increasing the overall activity of GS...

Research Grants64

  1. Flame Retardant and Adverse Perinatal Outcome (FRAPO)
    Morgan R Peltier; Fiscal Year: 2013
    ..There is emerging evidence that thyroid hormones have anti-inflammatory properties, improving survival and reducing the production of proin- flammatory ..
  2. Site-directed Chemotherapy for Breast Cancer using Novel Angiogenesis Inhibitor
    Shaker A Mousa; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Recent evidence has been provided that thyroid hormones may also play a role in carcinogenesis, and pioneering investigations in this area have demonstrated that the thyroid hormones such as 3,5,3&..
  3. Human developmental toxicity of metal mixture exposure from e-waste recycling
    Aimin Chen; Fiscal Year: 2010
    ..birth weight, small for gestational age [SGA], birth length, head circumference, anogenital distance [AGD]), thyroid hormones (TSH, T4, T3), and infant neurodevelopment (Bayley Scales of Infant Development-2 [BSID-2]) will be examined...
  4. Optimal Selective Thyroid Hormone Analogs for Metabolic Syndrome
    John D Baxter; Fiscal Year: 2010
    ..b>Thyroid hormones (THs) and their cognate nuclear receptors (TRs 1 and 2) are master regulators of metabolism...
  5. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2009
    ..The function of the thyroid gland is to produce the thyroid hormones, triiodothyronine (T3) and thyroxine (T4), which regulate transcription of numerous important genes through ..
  6. Effect of Polybrominated Diphenal Ether Flame Retardant Exposure on Osteogenesis
    Deena J Small; Fiscal Year: 2010
    ..These compounds are endocrine disrupting chemicals with a structure very similar to thyroid hormones, although the molecular mechanism(s) by which PBDE modifies thyroid hormone function is (are) not clear...
  7. PERCHLORATE AND THYROID HORMONES IN PREGNANCY AND INFANTS IN SOUTHERN CALIFORNIA
    Craig M Steinmaus; Fiscal Year: 2013
    ..cord blood in 857 mother-infant pairs will also be used to measure perchlorate, thiocyanate, iodide, and thyroid hormones. All of these measurements will be used to investigate associations between perchlorate and thyroid hormones ..
  8. PHAHs and Thyroid Cancer Risk in DoDSR Cohort
    Yawei Zhang; Fiscal Year: 2013
    ..coding for enzymes involved in the regulation, metabolism, or functional activities of PHAHs and endogenous thyroid hormones. The proposed study will be conducted using PRE-DIAGNOSTIC sera from the Department of Defense Serum ..
  9. Deiodinase Activity as a Biomarker of Response to Brominated Flame Retardants
    Heather M Stapleton; Fiscal Year: 2012
    ..that PBDE levels in pregnant women are significantly associated with increased circulating levels of maternal thyroid hormones, decreases in birth weight, and reductions in head circumference in infants...
  10. PCBs, PBDEs, Hearing Loss & Attention/Impulsivity: Mechanistic Studies in Animals
    Susan L Schantz; Fiscal Year: 2010
    ..and the extent to which these effects are mediated indirectly through PCB or PBDE effects on circulating thyroid hormones. A second major goal is to understand the mechanisms through which PCBs damage the cohclea and produce ..
  11. The role of Type 3 deiodinase in Brain Sexual Differentiation
    Arturo Hernandez; Fiscal Year: 2010
    ..b>Thyroid hormones (TH) are known to exert profound effects in the developing brain as well as to antagonize in this tissue the ..
  12. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2012
    ..Ultimately, endocytosis and proteolytic digestion allows for release of active thyroid hormones to the bloodstream while deiodination of iodotyrosines reclaims iodide for future Tg iodination...
  13. Thyroid Hormone Action
    Thomas Scanlan; Fiscal Year: 2009
    ..chemical structure, T1AM shares striking similarities in production level, distribution, and actions with the thyroid hormones T4 and T3...
  14. Thyroid hormone regulation of vasculature in adult myocardium
    Anthony Martin Gerdes; Fiscal Year: 2010
    ..This proposal will test the overall hypothesis that thyroid hormones promote myocardial angiogenesis by sprouting angiogenesis and intussusceptive angiogenesis via an Akt ..
  15. Physiological Factors Driving Maturation of Neonatal Beta Cells
    Susan Bonner-Weir; Fiscal Year: 2013
    ..of the adult provides the landscape of these changes: at P1 blood glucose levels are low, as are levels of thyroid hormones (T3 and T4), of corticosterone (the main glucocorticoid of the rat) and of prolactin, and the diet is only ..
  16. Early-life phthalate exposure, thyroid function and child cognitive development
    ROBIN MARJORIE WHYATT; Fiscal Year: 2013
    ..b>Thyroid hormones during pregnancy and early childhood are critical to brain development, and even modest reductions in hormone ..
  17. TSH and Bone
    Mone Zaidi; Fiscal Year: 2013
    ..euthyroid TSHR mice had an equally profound phenotype suggested that the effects of TSH were independent of thyroid hormones. Nonetheless, it remains unclear whether TSHR activation by stimulating antibodies in Graves'disease ..
  18. Subclinical thyroid dysfunction in the elderly
    Anne R Cappola; Fiscal Year: 2013
    ..b>Thyroid hormones are the seventh most commonly prescribed drugs in the US, and frequently are not appropriately monitored...
  19. Thyroid regulation of cardiomyocyte maturation
    KENT L R THORNBURG; Fiscal Year: 2013
    ..Because maternal thyroid hormones cross the placenta and influence fetal levels, maternal thyroid disease may seriously affect heart ..
  20. HUMAN CYTOSOLIC SULFOTRANSFERASES
    Charles N Falany; Fiscal Year: 2013
    ..Sulfation is a major conjugation reaction for many endogenous sterols, catecholamines, bile acids and thyroid hormones as well as xenobiotics and therapeutic drugs...
  21. Metabolism During Mechanical Circulatory Support in the Developing Heart
    Michael A Portman; Fiscal Year: 2013
    ..Substantial abnormalities in hormonal homeostasis, such as decreases in circulating levels of thyroid hormones, occur during both shorter term cardiopulmonary bypass (CPB) and longer term ECMO...
  22. Longitudinal study of exposure to PBDEs and PFCs and child neurobehavior
    Kimberly Yolton; Fiscal Year: 2013
    ..specific aims are to: 1) investigate the associations between prenatal and postnatal exposures to PBDEs and thyroid hormones and child neurobehavior;2) examine the associations between prenatal and postnatal exposures to PFCs and ..
  23. Development of an HTS assay to identify FXR antagonists
    Thomas P Burris; Fiscal Year: 2010
    ..applicant): Members of the human nuclear hormone receptor (NR) superfamily serve as receptors for steroids, thyroid hormones, retinoids, oxysterols, fatty acids, and bile acids...
  24. Perinatal Depression &Anxiety: Relationships with Late Pregnancy Thyroid Status
    CORT ANDREW PEDERSEN; Fiscal Year: 2012
    ..low (but normal range) thyroid hormone levels during late pregnancy but then have higher levels of other thyroid hormones after giving birth...
  25. Selective modulation of thyroid hormone receptors to promote remyelination
    Peter A Calabresi; Fiscal Year: 2013
    ..b>Thyroid hormones (THs) play a critical role in developmental myelination, however their role in remyelination has not yet been ..
  26. SNRP Program at UCC
    Maria Bykhovskaia; Fiscal Year: 2012
    ..Three new scientists will address the issues of oxidative damage in Huntington disease, direct effects of thyroid hormones on the nAChR and on synapse remodelling, and modulation of potassium channels by spermine...
  27. PBDE Body Burdens, House Dust Concentrations and Associations with Thyroid Hormon
    Lyndsey Darrow; Fiscal Year: 2012
    ..in a cohort of 80 children between 2 and 5 years, (c) explore associations between serum levels of PBDEs and thyroid hormones in young children, and (d) explore correlations between PBDEs concentrations in house dust and PBDE serum ..
  28. Lipid acceleration of transthyretin amyloidosis
    Irit Rappley; Fiscal Year: 2012
    ..This protein normally functions as a homotetramer to transport thyroid hormones and holo- retinol binding protein in the blood and cerebrospinal fluid...
  29. MOLECULAR MECHANISMS OF THYROID HORMONE ACTION
    Fredric E Wondisford; Fiscal Year: 2013
    ..a better understanding of the central regulation of the hypothalamic- pituitary-thyroid axis (HPT axis) by thyroid hormones (T4 and T3) and thyrotropin-releasing hormone (TRH)...
  30. Developmental Neuroendocrine Effects of PCBs and PBDEs: Parallels with ADHD
    RICHARD FIELD SEEGAL; Fiscal Year: 2010
    ..that developmental exposure to PCBs and PBDEs, due to their ability to alter central catecholamines and/or thyroid hormones during critical periods of development, are etiologic factors responsible for the contaminant induced ..
  31. Nutritional and Hormonal Pathways for Reduction of ApoB-lipoproteins
    Li Shin Huang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Thyroid hormones reduce cholesterol and have been proposed to function as a hormonal and nutritional therapy for hypercholesterolemia...
  32. Pre- and Postnatal PBDE Exposure, Thyroid Hormones, and Neurodevelopment
    JULIE BETH HERBSTMAN; Fiscal Year: 2013
    ..of brain development (from gestation through adolescence);and 2) determine the impact of PBDE exposure on thyroid hormones as an independent effect or mediator of PBDE-induced neurotoxicity throughout childhood...
  33. MOLECULAR BASIS FOR ETHANOL-INDUCED HYPOTHYROIDISM
    Robert Zoeller; Fiscal Year: 1993
    ..b>Thyroid hormones are important regulators of body temperature...
  34. CFTR regulation of thyroid transport
    Peying Fong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Thyroid hormones function in diverse and important physiological roles throughout the life an organism, ranging from the development of multiple organ systems to the regulation of metabolic rate...
  35. Neuropsychological & Thyroid Effects of Perfluorinated Compounds in Older Adults
    Edward Fitzgerald; Fiscal Year: 2009
    ..Remaining serum was archived and analyzed in 2005-06 for PBDEs, DLCs, and thyroid hormones. A total of 174 persons still have archived serum available...
  36. HEMOSTATIC DEFECTS AND THYROID HORMONE THERAPY
    WINIFRED DODDS; Fiscal Year: 1990
    ..The longterm objectives of this proposal are to establish the clinical efficacy and mechanism(s) of action of thyroid hormones in the treatment of hereditary and/or acquired hemostatic defects...
  37. CARDIAC MUSCLE CELL DEVELOPMENT AND NUCLEAR PROTEINS
    JASWANT BHORJEE; Fiscal Year: 1990
    ..in culture exhibit the developmentally regulated profiles of the myosin isoenzymes in the presence of thyroid hormones. We will examine the in vitro and in vivo development stage-specific distribution of the metabolically ..
  38. NUCLEAR HORMONE ACTION--ROLE OF UBIQUITIN PATHWAYS
    Zafar Nawaz; Fiscal Year: 2003
    Steroids, vitamins, retinoids, and thyroid hormones exert profound effects on cell growth, development, differentiation, homeostasis and tumorigenesis through their cognate nuclear receptors which make up a superfamily of structurally ..
  39. BIO-ORGANIC CHEMISTRY OF OXIDATIVE PHENOLIC COUPLING
    CHARLES SIH; Fiscal Year: 2001
    ..Many heterocyclic products, including alkaloids, cyclic peptides, thyroid hormones, and glycopeptide antibiotics are biosynthesized via enzyme-catalyzed oxidative coupling...
  40. Levodopa Pharmokinetic Optimization by Metal Coordination
    Thomas Piccariello; Fiscal Year: 2009
    ..In rat studies, MCPs have been proven to favorably impact the PK of thyroid hormones (T3 and T4), furosemide and now, levodopa...
  41. THYROID HORMONE, EPILEPSY, AND CNS MATURATION
    SIENYAO CHOW; Fiscal Year: 1992
    ..The aim of this project is to assess the role of thyroid hormones in altering susceptibility of the brain to experimentally- induced seizures and to determine the site and ..
  42. TRH in mediating the bradycardia of caloric restriction
    Steven Swoap; Fiscal Year: 2005
    ..address important questions in cardiovascular biology concerning the roles of thyrotropin releasing hormone, thyroid hormones, the parasympathetic nervous system, and the sympathetic nervous system in the bradycardia of caloric ..
  43. Thyrotrope Proliferation by Thyroid Hormone
    ELI RIDGWAY; Fiscal Year: 2006
    ..secreted into the circulation and regulates the growth and function of the thyroid gland which produces the thyroid hormones. Thyrotrope cell function is, in turn, regulated by hypothalamic hormones (TRH and SRIF) and the circulating ..
  44. HORMONAL REGULATION OF THYROGLOBULIN GENE IN THYROIDS
    Chi Bom Chae; Fiscal Year: 1991
    ..cell metabolism including the synthesis of thyroglobulin (TG), the key precursor in the biosynthesis of thyroid hormones. In some thyroid tumors as well as in one thyroid rat cell line (FRTL-5R), the normal regulatory mechanism is ..
  45. Basic mechanisms of antidepressant augmentation
    Michael Newman; Fiscal Year: 2003
    ..Several agents including the thyroid hormones triiodothyronine (T3) and thyroxine (T4) have been used to reduce the lag period of ADs and augment their ..
  46. CATECHOLAMINE MODULATION OF THYROID HORMONE METABOLISM
    Harvey Katzeff; Fiscal Year: 1992
    ..The maintenance of muscle mass during weight loss is thought to be beneficial for long-term weight control. Thyroid hormones are important regulators of protein synthesis and catabolism and are themselves regulated by both diet and ..
  47. CABP GENE INTERACTION WITH VITAMIN D3 RECEPTOR
    Barry Komm; Fiscal Year: 1991
    The family of steroid and thyroid hormones has become one of the most intensely investigated group of ligands because of their nuclear localization and demonstratable impact on gene transcription...
  48. NORMAL AND DISORDERED THYROID HORMONE ECONOMY
    Jorge Silva; Fiscal Year: 1990
    ..Studies are planned in four major area of investigation: 1) the peripheral metabolism of thyroid hormones; 2) the mechanism of action of thyroid hormones; 3) regulation of thyroid cell grwoth; and 4) the ..
  49. GLYCOPROTEIN HORMONE ALPHA SUBUNIT & GENE TRANSCRIPTION
    PAMELA MELLON; Fiscal Year: 1992
    ..Thyroid stimulating hormone (TSH) stimulates the production of thyroid hormones which are involved in development and maintenance of metabolic stability...
  50. Neuroendocrine Consequences of Two Animal Models of Active Behavioral Coping
    DANA HELMREICH; Fiscal Year: 2009
    ..is little previous work examining the impact of active behavioral coping on acute stress-induced decreases in thyroid hormones. Interestingly we have preliminary evidence that acute inescapable stress can cause a decrease in peripheral ..
  51. THYROID HORMONE CONTROL OF BEHAVIOR & GENE EXPRESSION
    Stuart Stein; Fiscal Year: 1991
    b>Thyroid hormones (T3, T4) play a critical but only partially understood role in the development and maintenance of normal peripheral and central nervous system function, behavior, and learning...
  52. Thyroid Hormone (thyroxine) Function in Adult Human RPE
    RITA GETZ; Fiscal Year: 2003
    b>Thyroid hormones; thyroxine (T4) and triiodothyronine (T3), function in many body tissues to influence growth and metabolism, but little is known about thyroid hormone function in human retinal pigment epithelium (HRPE)...
  53. CHARACTERIZATION OF HYPOTHALAMO-LYMPHO--THYROID AXIS
    LEE NIEN CHAN; Fiscal Year: 1992
    ..by thyrotropin releasing hormone (TRH) and negatively by feedback from the thyroid gland in the form of thyroid hormones, T3 and T4...
  54. TRANSPORT AND ACTION OF THYROID HORMONES
    PATRICIA HINKLE; Fiscal Year: 1990
    ..This application addresses the specific question of how the thyroid hormones promote cell growth...
  55. SULFOTRANSFERASE EXPRESSION IN EPITHELIA AND CARCINOMAS
    THOMAS DOOLEY; Fiscal Year: 2001
    ..The preferred substrates for STP1, STP2, and STM, and the SULT1B2 gene products are phenolic drugs, thyroid hormones, and catecholamines...
  56. GENE REGULATION BY THYROID HORMONE RECEPTOR BETA
    MILAN BAGCHI; Fiscal Year: 2003
    The long-term goal of this proposal is to explore how the nuclear receptors of thyroid hormones regulate the expression of specific cellular genes. There are two major types of thyroid hormone receptors, TRalpha and TRbeta...
  57. REGULATION OF THYROID HORMONE METABOLISM
    Donald St Germain; Fiscal Year: 2003
    ..has occurred during the past decade in our understanding of the processes responsible for the production of thyroid hormones (TH), and the mechanisms whereby they exert their profound effects on cellular processes...
  58. GENETICS OF THYROID HORMONES IN MEXICAN AMERICANS
    PAUL SAMOLLOW; Fiscal Year: 2001
    DESCRIPTION: (Adapted from Investigator's Abstract) Thyroid hormones play major roles in the regulation of protein synthesis, basal metabolism, and lipolysis and lipogenesis...
  59. DIRECTED AXON GROWTH--HORMONAL CONTROL & GENE EXPRESSION
    Sally Hoskins; Fiscal Year: 1991
    ..Hormones are one such type of regulatory molecule, and for thyroid hormones, interaction with a chromatin-associated receptor molecule is the first step in the regulation of specific ..
  60. Gene discovery in a putative mouse model of ADHD
    Michael McDonald; Fiscal Year: 2004
    ..syndrome is a heritable condition caused by mutations in the TRbeta gene that typically result in elevated thyroid hormones, short stature, and tachycardia...
  61. HORMONAL REGULATION OF MAMMALIAN GENE EXPRESSION
    Ronald Evans; Fiscal Year: 1999
    ..to the identification of a superfamily of regulatory proteins that include receptors for steroid hormones, thyroid hormones and the vertebrate morphogen retinoic acid...
  62. REGULATION OF LIPOGENESIS BY THYROID HORMONES AND DIET
    Hedley Freake; Fiscal Year: 1993
    ..b>Thyroid hormones and dietary carbohydrate are two important regulators, interacting with each other to achieve the level of ..
  63. Rapid action of thyroid hormone on embryonic zebrafish neurons.
    Marc Yonkers; Fiscal Year: 2009
    DESCRIPTION (supplied by applicant) Thyroid hormones (THs) and neuronal excitability are both essential for fetal neurodevelopment. In vitro experiments suggest THs may regulate excitability during embryonic and neonatal stages...
  64. MEMBRANOGENESIS IN CRETINISM AND HYPERTHYROIDISM
    Paola Timiras; Fiscal Year: 1980
    ..directions, each a direct continuation of our original research: 1) to investigate the regulatory role of thyroid hormones on brain development and behavior by studying the effects of these hormones on number and characteristics of ..