progestins

Summary

Summary: Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.

Top Publications

  1. ncbi Progesterone improves acute recovery after traumatic brain injury in the aged rat
    Sarah M Cutler
    Department of Emergency Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Neurotrauma 24:1475-86. 2007
  2. pmc Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3
    Wendy Beguelin
    Instituto de Biologia y Medicina Experimental, CONICET, Vuelta de Obligado 2490, Buenos Aires C1428ADN, Argentina
    Mol Cell Biol 30:5456-72. 2010
  3. ncbi Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin
    R K Ross
    University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9181, USA
    J Natl Cancer Inst 92:328-32. 2000
  4. pmc Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids
    Tina R Hubler
    Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Cell Stress Chaperones 9:243-52. 2004
  5. ncbi Oral progestogens vs levonorgestrel-releasing intrauterine system for endometrial hyperplasia: a systematic review and metaanalysis
    Ioannis D Gallos
    Academic Unit of Obstetrics and Gynaecology, Birmingham Women s Hospital, Birmingham, UK
    Am J Obstet Gynecol 203:547.e1-10. 2010
  6. ncbi An update on the antiestrogenic effect of smoking: a literature review with implications for researchers and practitioners
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Menopause 11:104-9. 2004
  7. ncbi Glucocorticoid receptor mediates the effect of progesterone on uterine natural killer cells
    Wei Guo
    Immunology and Reproduction Biology Lab, Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, China
    Am J Reprod Immunol 67:463-73. 2012
  8. ncbi Oncologic and reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 adenocarcinoma: a systematic review
    Camille C Gunderson
    Johns Hopkins Hospital, Department of Gynecology and Obstetrics, 600 North Wolfe Street, Phipps 279, Baltimore, MD 21287, USA
    Gynecol Oncol 125:477-82. 2012
  9. pmc Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task
    Cheryl A Frye
    Department of Psychology, The University at Albany State University of New York, United States
    Neurobiol Learn Mem 88:208-16. 2007
  10. ncbi Risk of progression in complex and atypical endometrial hyperplasia: clinicopathologic analysis in cases with and without progestogen treatment
    L C Horn
    Institute of Pathology Gynecopathology, University of Leipzig, Liebigstrasse 26, D 04103 Leipzig, Germany
    Int J Gynecol Cancer 14:348-53. 2004

Detail Information

Publications295 found, 100 shown here

  1. ncbi Progesterone improves acute recovery after traumatic brain injury in the aged rat
    Sarah M Cutler
    Department of Emergency Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Neurotrauma 24:1475-86. 2007
    ..Thus, in aged male rats, treatment with 16 mg/kg progesterone improves short-term motor recovery and attenuates edema, secondary inflammation, and cell death after TBI...
  2. pmc Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3
    Wendy Beguelin
    Instituto de Biologia y Medicina Experimental, CONICET, Vuelta de Obligado 2490, Buenos Aires C1428ADN, Argentina
    Mol Cell Biol 30:5456-72. 2010
    ..Our findings reveal a novel therapeutic intervention for PR- and ErbB-2-positive breast tumors via the specific blockage of ErbB-2 nuclear translocation...
  3. ncbi Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin
    R K Ross
    University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9181, USA
    J Natl Cancer Inst 92:328-32. 2000
    ..Few data exist on the association between CHRT and breast cancer risk. We determined the effects of CHRT on a woman's risk of developing breast cancer in a population-based, case-control study...
  4. pmc Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids
    Tina R Hubler
    Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Cell Stress Chaperones 9:243-52. 2004
    Expression of FKBP51, a large molecular weight immunophilin, is strongly enhanced by glucocorticoids, progestins, and androgens. However, the activity of a 3...
  5. ncbi Oral progestogens vs levonorgestrel-releasing intrauterine system for endometrial hyperplasia: a systematic review and metaanalysis
    Ioannis D Gallos
    Academic Unit of Obstetrics and Gynaecology, Birmingham Women s Hospital, Birmingham, UK
    Am J Obstet Gynecol 203:547.e1-10. 2010
    ..To conduct a systematic review and metaanalysis of studies evaluating the regression rate of endometrial hyperplasia with oral progestogens and levonorgestrel-releasing intrauterine system...
  6. ncbi An update on the antiestrogenic effect of smoking: a literature review with implications for researchers and practitioners
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup, Denmark
    Menopause 11:104-9. 2004
    ..DESIGN Summary of own research and a MEDLINE search of English-language literature on the antiestrogenic effect of smoking in pre- and postmenopausal women published during the past two decades...
  7. ncbi Glucocorticoid receptor mediates the effect of progesterone on uterine natural killer cells
    Wei Guo
    Immunology and Reproduction Biology Lab, Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, China
    Am J Reprod Immunol 67:463-73. 2012
    ..Uterine natural killer cells (uNK) do not express progesterone receptor, but express glucocorticoid receptor (GR). So, we speculate that progesterone may regulate uNK cells through a GR-mediated process...
  8. ncbi Oncologic and reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 adenocarcinoma: a systematic review
    Camille C Gunderson
    Johns Hopkins Hospital, Department of Gynecology and Obstetrics, 600 North Wolfe Street, Phipps 279, Baltimore, MD 21287, USA
    Gynecol Oncol 125:477-82. 2012
    ..The objective of this review was to analyze published contemporary oncologic and reproductive outcomes in women with endometrial hyperplasia or cancer undergoing medical management with progestin therapy...
  9. pmc Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task
    Cheryl A Frye
    Department of Psychology, The University at Albany State University of New York, United States
    Neurobiol Learn Mem 88:208-16. 2007
    Steroid modulation of cognitive function has focused on estrogen (E(2)), but progestins naturally co-vary with E(2) and may also influence cognitive performance...
  10. ncbi Risk of progression in complex and atypical endometrial hyperplasia: clinicopathologic analysis in cases with and without progestogen treatment
    L C Horn
    Institute of Pathology Gynecopathology, University of Leipzig, Liebigstrasse 26, D 04103 Leipzig, Germany
    Int J Gynecol Cancer 14:348-53. 2004
    ..0001). Endometrial hyperplasia without atypia is likely to respond to hormonal treatment. Especially in postmenopausal situation, atypical hyperplasia should be treated with total hysterectomy...
  11. pmc 17-alpha-hydroxyprogesterone caproate for the prevention of preterm birth in women with prior preterm birth and a short cervical length
    Vincenzo Berghella
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
    Am J Obstet Gynecol 202:351.e1-6. 2010
    ..We sought to evaluate 17-alpha-hydroxyprogesterone caproate (17P) for prevention of preterm birth (PTB) in women with prior spontaneous PTB (SPTB) and cervical length (CL) <25 mm...
  12. ncbi Progestin-dependent progression of human breast tumor xenografts: a novel model for evaluating antitumor therapeutics
    Yayun Liang
    Dalton Cardiovascular Research Center, Veterinary Pathobiology, and Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Cancer Res 67:9929-36. 2007
    Recent clinical trials indicate that synthetic progestins may stimulate progression of breast cancer in postmenopausal women, a result that is consistent with studies in chemically-induced breast cancer models in rodents...
  13. ncbi Progestogen for treating threatened miscarriage
    Hayfaa A Wahabi
    Chair of Evidence Based Healthcare and Knowledge Translation, King Saud University, Riyadh, Saudi Arabia, 11451
    Cochrane Database Syst Rev 12:CD005943. 2011
    ..Inadequate secretion of progesterone in early pregnancy has been linked to the aetiology of miscarriage and progesterone supplementation has been used as a treatment for threatened miscarriage to prevent spontaneous pregnancy loss...
  14. ncbi Progestin effects on long-term growth, death, and Bcl-xL in breast cancer cells
    M R Moore
    Department of Biochemistry and Molecular Biology, Marshall University School of Medicine, Huntington, West Virginia, 25704, USA
    Biochem Biophys Res Commun 277:650-4. 2000
    The effect of progestins on proliferation of breast cancer has been a controversial area. We have consistently reported progestin stimulation of proliferation in the progesterone receptor-rich human breast cancer cell line T47D...
  15. ncbi The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents
    C A Frye
    Department of Psychology, Biological Sciences and The Center for Neuroscience Research, The University at Albany, SUNY, Albany, NY 12222, USA
    Brain Res Brain Res Rev 37:201-22. 2001
    b>Progestins and androgens modulate sexual receptivity in rodents, in part through mechanisms independent of traditional intracellular steroid receptors...
  16. ncbi Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury
    Florencia Labombarda
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, CONICET, Buenos Aires, Argentina
    Glia 57:884-97. 2009
    ..Thus, progesterone effects on oligodendrogenesis and myelin proteins may constitute fundamental steps for repairing traumatic injury inflicted to the spinal cord...
  17. ncbi Role of progesterone in endometrial cancer
    J Julie Kim
    Department Obstetrics and Gynecology, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    Semin Reprod Med 28:81-90. 2010
    ..This review highlights what is known thus far regarding the efficacy of progestin therapy in the clinic and the role of progesterone in endometrial cancer cell behavior and gene regulation...
  18. ncbi National use of postmenopausal hormone therapy: annual trends and response to recent evidence
    Adam L Hersh
    Stanford Prevention Research Center, Program on Prevention Outcomes and Practices, Stanford University School of Medicine, Stanford, Calif 94305, USA
    JAMA 291:47-53. 2004
    ..Recent evidence from randomized trials published in July 2002 demonstrated adverse cardiovascular disease events and other risks with hormone therapy in the form of oral estrogen combined with progestin...
  19. pmc Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
    Daniel Schramek
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
    Nature 468:98-102. 2010
    ..In particular, synthetic progesterone derivatives (progestins) such as medroxyprogesterone acetate (MPA), used in millions of women for hormone replacement therapy and ..
  20. ncbi Increased risk of breast cancer following different regimens of hormone replacement therapy frequently used in Europe
    Claudia Stahlberg
    Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Int J Cancer 109:721-7. 2004
    ..The aim of this study was to investigate whether different treatment regimens or the androgenecity of progestins influence the risk of breast cancer differently...
  21. ncbi Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort
    Agnes Fournier
    Equipe E3N, Institut National de la Sante et de la Recherche Medicale INSERM, Villejuif, France
    Int J Cancer 114:448-54. 2005
    ..The risk was significantly greater (p <0.001) with HRT containing synthetic progestins than with HRT containing micronized progesterone, the RRs being 1.4 [1.2-1.7] and 0.9 [0.7-1.2], respectively...
  22. pmc Progestins in hormone replacement therapies reactivate cancer stem cells in women with preexisting breast cancers: a hypothesis
    Kathryn B Horwitz
    Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 93:3295-8. 2008
    Why does hormone replacement therapy (HRT) with estrogens plus progestins increase the risk of breast cancer? First, experimental estrogen receptor-positive (ER+) and progesterone receptor-positive (PR+) human breast cancers contain a ..
  23. pmc The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study
    A Van Hylckama Vlieg
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 P, PO Box 9600, NL 2300 RC Leiden, Netherlands
    BMJ 339:b2921. 2009
    ..To assess the thrombotic risk associated with oral contraceptive use with a focus on dose of oestrogen and type of progestogen of oral contraceptives available in the Netherlands...
  24. ncbi Follow-up examinations of bitches after conservative treatment of pyometra with the antigestagen aglepristone
    K Trasch
    Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals, Justus Liebig University, Giessen, Germany
    J Vet Med A Physiol Pathol Clin Med 50:375-9. 2003
    ..The presented data show that treatment of pyometra by aglepristone results in a high healing rate. The recurrence rate can be minimized by the selection of bitches without ovarian cysts and cystic endometrial hyperplasia...
  25. pmc Progestin therapy of complex endometrial hyperplasia with and without atypia
    Susan D Reed
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98115, USA
    Obstet Gynecol 113:655-62. 2009
    ..To assess the likelihood of histologic persistence/progression of complex hyperplasia and atypical hyperplasia among women treated with progestin compared with those not treated, with attention to type, dose, and duration...
  26. ncbi A novel immortalized human endometrial stromal cell line with normal progestational response
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    Endocrinology 145:2291-6. 2004
    ..In summary, an immortalized HESC line has been developed that is karyotypically, morphologically, and phenotypically similar to the primary parent cells, and it is a powerful and consistent resource for in vitro work...
  27. ncbi Age-related pregnancy results and further examination of bitches after aglepristone treatment of pyometra
    P Jurka
    Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland
    Reprod Domest Anim 45:525-9. 2010
    ..It seems necessary to mate bitches in the first or second oestrus after finishing treatment. The efficacy of treatment can be measured by the after-treatment pregnancy rate...
  28. ncbi Relationship between long durations and different regimens of hormone therapy and risk of breast cancer
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    JAMA 289:3254-63. 2003
    ..Women using combined estrogen and progestin hormone replacement therapy (CHRT) have an increased risk of breast cancer; however, data on use for long durations and on risk associated with patterns of use are lacking...
  29. ncbi Progestins inhibit expression of MMPs and of angiogenic factors in human ectopic endometrial lesions in a mouse model
    Verena Mönckedieck
    Institute of Molecular Biology, University Hospital Essen, 45122 Essen, Germany
    Mol Hum Reprod 15:633-43. 2009
    b>Progestins are successfully used in the treatment of endometriosis; however, the exact mechanisms of their action are still unsolved...
  30. ncbi Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways
    Romina P Carnevale
    Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires C1428ADN, Argentina
    Mol Endocrinol 21:1335-58. 2007
    Accumulating evidence indicates that progestins are involved in controlling mammary gland tumorigenesis. Here, we assessed the molecular mechanisms of progestin action in breast cancer models with different phenotypes...
  31. ncbi Characteristics and metabolic effects of estrogen and progestins contained in oral contraceptive pills
    Regine Sitruk-Ware
    Population Council and Rockefeller University, New York, NY 10065, USA
    Best Pract Res Clin Endocrinol Metab 27:13-24. 2013
    Estrogen and progestins have been used by millions of women as effective combined oral contraceptives...
  32. ncbi A prospective study of different types of hormone replacement therapy use and the risk of subsequent breast cancer: the women's health in the Lund area (WHILA) study (Sweden)
    Helena Jernstrom
    Department of Oncology, The Jubileum Institute, Lund University Hospital, S 221 85 Lund, Sweden
    Cancer Causes Control 14:673-80. 2003
    ..Reports suggest that combined estrogen plus progestin hormone replacement therapy (HRT) confers a higher breast cancer risk than estrogen alone. We aimed to establish whether breast cancer risk depends on the type of HRT formula...
  33. ncbi Progestins and breast cancer
    Jorge R Pasqualini
    Hormones and Cancer Research Unit, Institut de Puériculture et de Périnatalogie, Paris, France
    Gynecol Endocrinol 23:32-41. 2007
    b>Progestins exert their progestational activity by binding to the progesterone receptor (form A, the most active and form B, the less active) and may also interact with other steroid receptors (androgen, glucocorticoid, mineralocorticoid, ..
  34. pmc The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention
    Andrea R Daniel
    University of Minnesota Cancer Center, 420 Delaware Street SE, MMC 806, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 24:2126-38. 2010
    ..In sum, the PR hinge region is multifunctional. Understanding the ability of this region to couple acetylation, phosphorylation, and nuclear entry may provide clues to mechanisms of altered hormone responsiveness...
  35. pmc Biological characterization of non-steroidal progestins from botanicals used for women's health
    M F Toh
    Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60607, USA
    Steroids 77:765-73. 2012
    Progesterone plays a central role in women's reproductive health. Synthetic progestins, such as medroxyprogesterone acetate (MPA) are often used in hormone replacement therapy (HRT), oral contraceptives, and for the treatment of ..
  36. ncbi Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells
    Jeffrey D Bray
    Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    J Steroid Biochem Mol Biol 97:328-41. 2005
    ..b>Progestins are compounds that demonstrate progesterone-like activity and are used in oral contraception, hormone therapy, ..
  37. pmc Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2
    Lisa K Pierson-Mullany
    University of Minnesota Cancer Center, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Mol Cell Biol 24:10542-57. 2004
    ..PR phospho-Ser400-specific antibodies revealed regulated phosphorylation of Ser400 in response to progestins and mitogens, and this correlated with increased CDK2 levels and activity...
  38. ncbi Several synthetic progestins with different potencies adversely affect reproduction of fish
    Tamsin J Runnalls
    Institute for the Environment, Brunel University, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, UK
    Environ Sci Technol 47:2077-84. 2013
    Synthetic progestins are widely used as a component in both contraceptives and in hormone replacement therapy (HRT), both on their own and in combination with EE2...
  39. ncbi Progestin regulation of vascular endothelial growth factor in human breast cancer cells
    S M Hyder
    Department of Integrative Biology, Pharmacology and Physiology, University of Texas Health Sciences Center Houston, 77225, USA
    Cancer Res 58:392-5. 1998
    ..This effect is blocked by the antiprogestin RU 486. In addition to progesterone, a number of synthetic progestins used in oral contraceptives (e.g...
  40. pmc Mechanisms of cyclin-dependent kinase inactivation by progestins
    E A Musgrove
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Mol Cell Biol 18:1812-25. 1998
    ..In breast cancer cells the predominant effect of synthetic progestins is long-term growth inhibition and arrest in G1 phase...
  41. ncbi Dienogest
    R H Foster
    Adis International Limited, Auckland, New Zealand
    Drugs 56:825-33; discussion 834-5. 1998
    ..The drug does not produce androgenic adverse effects and has little clinically significant effect on metabolic, lipid and haemostatic parameters...
  42. ncbi Progestin regulated miRNAs that mediate progesterone receptor action in breast cancer
    Dawn R Cochrane
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Denver, USA
    Mol Cell Endocrinol 355:15-24. 2012
    Progesterone receptors (PRs) mediate response to progestins in the normal breast and breast cancer...
  43. ncbi Influence of different hormonal regimens on endometrial microvascular density and VEGF expression in women suffering from breakthrough bleeding
    P A W Rogers
    Centre for Women s Health Research, Clinic, Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Hum Reprod 20:3341-7. 2005
    ....
  44. ncbi Overview on the effects of progestins on bone
    Jos H H Thijssen
    Endocrinological Laboratory, University Medical Center Utrecht KE 03 139 2, P O Box 85090, 3508 AB Utrecht, The Netherlands
    Maturitas 46:S77-87. 2003
    ..An overview of the effects of progestins on bone is given...
  45. ncbi Anti-progestins suppress the growth of established tumors induced by 7,12-dimethylbenz(a)anthracene: comparison between RU486 and a new 21-substituted-19-nor-progestin
    Ronald D Wiehle
    Repros Therapeutics Inc, The Woodlands, TX 77380, USA
    Oncol Rep 18:167-74. 2007
    ..Anti-progestins resulted in the regression in the size of the existing tumors, and in the suppressed development of new tumors ..
  46. ncbi Progesterone and progestins: neuroprotection and myelin repair
    Michael Schumacher
    UMR 788 Inserm and University Paris Sud 11, Kremlin Bicetre, France
    Curr Opin Pharmacol 8:740-6. 2008
    ..of its beneficial effects on the nervous system also suggests novel therapeutic benefits for some synthetic progestins derived from progesterone, currently used for contraception or in postmenopausal hormone replacement therapies (..
  47. pmc Progestin and thrombin regulate tissue factor expression in human term decidual cells
    C J Lockwood
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 94:2164-70. 2009
    ..The identity and potential regulation of TF-expressing cells at the human maternal-fetal interface that confers hemostatic protection during normal and preterm delivery is unclear...
  48. ncbi Dydrogesterone support in threatened miscarriage
    Mazen Y El-Zibdeh
    Department of Obstetrics and Gynaecology, Islamic Hospital, Amman, Jordan
    Maturitas 65:S43-6. 2009
    ..The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage...
  49. ncbi Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis
    Jane E Norman
    Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
    Lancet 373:2034-40. 2009
    ..We investigated the use of progesterone for prevention of preterm birth in twin pregnancy...
  50. ncbi Endogenous levels of 5 alpha-reduced progestins and androgens in fetal vs. adult rat brains
    C K Kellogg
    Department of Brain and Cognitive Sciences, Room 186 Meliora Hall, University of Rochester, Rochester, NY 14627, USA
    Brain Res Dev Brain Res 115:17-24. 1999
    ..steroid metabolites may have an impact during development, endogenous levels of 5 alpha-reduced androgens and progestins and their parent hormones were measured in male and female fetal brains over the last 5 days of gestation...
  51. ncbi Menopause, estrogens, progestins, or their combination on body weight and anthropometric measures
    Angelo Cagnacci
    Department of Obstetrics Gynecology and Pediatrics, University of Modena, Modena, Italy
    Fertil Steril 88:1603-8. 2007
    ..To evaluate modification in body weight and anthropometric indexes in women at the time of menopause...
  52. ncbi Unique biphasic progestagen profile in parturient and non-parturient giant pandas (Ailuropoda melanoleuca) as determined by faecal hormone monitoring
    David C Kersey
    Smithsonian Conservation Biology Institute, Center for Species Survival, Front Royal, Virginia 22630, USA
    Reproduction 140:183-93. 2010
    ..However, progestagen excretion patterns throughout this period could not be used to discriminate among non-pregnant, pregnant or pseudopregnant states...
  53. pmc The role of glucocorticoids and progestins in inflammatory, autoimmune, and infectious disease
    A Sasha Tait
    National Institute of Mental Health NIH, Rockville, MD 20852, USA
    J Leukoc Biol 84:924-31. 2008
    ....
  54. pmc Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse
    Cheryl A Frye
    Department of Psychology, Centers for Neuroscience and Life Sciences Research, The University at Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:209-19. 2007
    ..Recent findings from our laboratory which demonstrate that progestins can enhance approach to novel stimuli, conditioning, and reinforcement are reviewed...
  55. ncbi Progesterone, BDNF and neuroprotection in the injured CNS
    Teresa Coughlan
    Department of Infection and Immunity, Academic Unit of Pathology, The Medical School, University of Sheffield, Sheffield, UK
    Int J Neurosci 119:1718-40. 2009
    ..Both the effects of progesterone and the expression of BDNF can clearly vary following stroke-like injuries, however we found no evidence for a neuroprotective relationship between progesterone and BDNF...
  56. pmc Development of an animal experimental model to study the effects of levonorgestrel on the human endometrium
    M L Alvarez Gonzalez
    Laboratory of Tumor and Development Biology, GIGA Research, B23, University de Liège, Sart Tilman, B 4000 Liege, Belgium
    Hum Reprod 24:697-704. 2009
    ..This study was designed to develop an animal model to test the response of endometrium to local progestin delivery...
  57. pmc Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo
    Lifei Liu
    Program in Neuroscience, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, California 90033, USA
    Endocrinology 151:5782-94. 2010
    ..Here, we report the efficacy of seven clinically relevant progestins alone or in combination with 17β-estradiol (E(2)) on adult rNPC proliferation and hippocampal cell viability in ..
  58. ncbi Estradiol and progestins differentially modulate leukocyte infiltration after vascular injury
    Dongqi Xing
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, UAB Station, Birmingham, AL 35294, USA
    Circulation 109:234-41. 2004
    ..This study tested the hypothesis that E2 inhibits the migration of inflammatory cells, particularly granulocytes, into the rat carotid arteries after acute endoluminal injury and that MPA blocks this effect...
  59. pmc Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways
    Cheryl A Frye
    Department of Psychology, The University at Albany, SUNY, Albany, NY 12222, USA
    Steroids 73:906-13. 2008
    In the ventral tegmental area (VTA), progestins facilitate lordosis via rapid actions at membrane dopamine Type 1-like (D(1)) and/or GABA(A) receptors (GBRs), rather than via cognate, intracellular progestin receptors (PRs)...
  60. ncbi Menopausal hormone replacement therapy and risk of ovarian cancer
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, MSC 7234, Rockville, MD 20852, USA
    JAMA 288:334-41. 2002
    ..The association between menopausal hormone replacement therapy and ovarian cancer is unclear...
  61. pmc Multimodal regulation of E2F1 gene expression by progestins
    Hilary E Wade
    Duke University Medical Center, Department of Pharmacology and Cancer Biology, Durham, NC 27710, USA
    Mol Cell Biol 30:1866-77. 2010
    ..which can bind to GC-rich DNA within the E2F1 promoter, is required for maximal induction of E2F1 expression by progestins. Taken together, these results suggest a new paradigm for multimodal regulation of target gene expression by PR.
  62. pmc Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease
    Miguel A Hernán
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Epidemiology 19:766-79. 2008
    ..Observational studies had previously suggested reduced CHD risk in hormone users...
  63. ncbi Carcinogenicity of combined oestrogen-progestagen contraceptives and menopausal treatment
    Vincent Cogliano
    Lancet Oncol 6:552-3. 2005
  64. ncbi Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases
    Andrew Skildum
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, MMC 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 19:327-39. 2005
    b>Progestins induce proliferation of breast cancer cells and are implicated in the development of breast cancer...
  65. ncbi Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancer
    Stephen N Birrell
    Dame Roma Mitchell Cancer Research Laboratories, The University of Adelaide, Hanson Institute, PO Box 14, Rundle Mall, South Australia, 5000, Australia
    FASEB J 21:2285-93. 2007
    There is now considerable evidence that using a combination of synthetic progestins and estrogens in hormone replacement therapy (HRT) increases the risk of breast cancer compared with estrogen alone...
  66. pmc Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study
    Agnes Fournier
    Institut National de la Sante et de la Recherche Medicale, ERI 20, Institut Gustave Roussy, Villejuif, France
    Breast Cancer Res Treat 107:103-11. 2008
    ..69 (1.50-1.91) for estrogen combined with other progestagens. This latter category involves progestins with different physiologic activities (androgenic, nonandrogenic, antiandrogenic), but their associations with ..
  67. pmc Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors
    Emily J Faivre
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 22:823-37. 2008
    ..Our data demonstrate the therapeutic potential for PR-targeted breast cancer treatment by exploiting multiple nodes along the PR signaling pathway, including PR-B, EGFR, c-Src, MAPK, or Sp1...
  68. doi Oral contraceptives and individual variability of circulating levels of ethinyl estradiol and progestins
    Joseph W Goldzieher
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 78212, USA
    Contraception 78:4-9. 2008
  69. pmc Progesterone induction of the 11beta-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase tracking
    Alicia Subtil-Rodríguez
    Centre de Regulacio Genomica, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E 08003 Barcelona, Spain
    Mol Cell Biol 28:3830-49. 2008
    ..This is not unique to this promoter, as AG490 also alters the expression of other progesterone-regulated genes...
  70. pmc A prospective study of postmenopausal hormone use and ovarian cancer risk
    K N Danforth
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Br J Cancer 96:151-6. 2007
    ..53, 95% CI 1.20-1.94). Recency of use was not significantly associated with ovarian cancer risk, but statistical power was limited here...
  71. pmc Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells
    Cecilia Proietti
    Instituto de Biología y Medicina Experimental IBYME, CONICET, Buenos Aires 1428, Argentina
    Mol Cell Biol 25:4826-40. 2005
    ..In the present study, we explored the capacity of progestins to modulate Stat3 transcriptional activation in an experimental model of hormonal carcinogenesis in which the ..
  72. ncbi Hormone therapy and ovarian cancer
    Lina Steinrud Mørch
    Gynaecological Clinic, Rigshospitalet, Copenhagen University, 2100 Copenhagen, Denmark
    JAMA 302:298-305. 2009
    ..Studies have suggested an increased risk of ovarian cancer among women taking postmenopausal hormone therapy. Data are sparse on the differential effects of formulations, regimens, and routes of administration...
  73. ncbi Overlapping but distinct gene regulation profiles by glucocorticoids and progestins in human breast cancer cells
    Yihong Wan
    Department of Pathology and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Endocrinol 16:1204-14. 2002
    Glucocorticoids and progestins bind to receptors that share many structural and functional similarities, including virtually identical DNA recognition specificity. Nonetheless, the two hormones mediate very distinct biological functions...
  74. ncbi Progesterone for preterm birth prevention: an evolving intervention
    Alan Thevenet N Tita
    Center for Women s Reproductive Health, Maternal Fetal Medicine Division, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Obstet Gynecol 200:219-24. 2009
    ..In some women, progesterone reduces the risk of PTB. Further study is required to identify appropriate candidates and optimal formulations...
  75. ncbi Limited knowledge on progestogen-only contraception and risk of venous thromboembolism
    Annica Bergendal
    Department of Medicine, Centre for Pharmacoepidemiology, Karolinska Institutet, Solna, 17176 Stockholm, Sweden
    Acta Obstet Gynecol Scand 88:261-6. 2009
    ..To assess the current knowledge concerning progestogen-only contraception (POC) and risks of venous thromboembolism (VTE)...
  76. ncbi Progestins and place preference conditioning after paced mating
    Oscar Gonzalez-Flores
    Centro de Investigacion en Reproduccion Animal, CINVESTAV Universidad Autónoma de Tlaxcala, Mexico
    Horm Behav 46:151-7. 2004
    ..b>Progestins were dissolved in propylene glycol and intravenously (iv) injected through an indwelling jugular catheter before ..
  77. ncbi Effects of hormone replacement therapy regimens on mammographic breast density: the role of progestins
    Naile Bolca Topal
    Department of Radiology, Faculty of Medicine, Uludag University, Bursa, Turkey
    J Obstet Gynaecol Res 32:305-8. 2006
    ..To evaluate the effects of different regimens of hormone replacement therapy (HRT) on mammographic breast density...
  78. ncbi Pharmacological and endogenous progestins induce vascular endothelial growth factor expression in human breast cancer cells
    S M Hyder
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center Houston, Houston, TX 77030, USA
    Int J Cancer 92:469-73. 2001
    ..in a number of systems, including T47-D human breast cancer cells in which VEGF protein levels are elevated by progestins. In the present study, we investigated the effect of progestins on VEGF mRNA levels in human breast cancer cells...
  79. ncbi The risk of breast cancer linked to menopausal hormone therapy
    Sarah Sæther
    Department of Community Medicine, University of Tromsø, Norway
    Tidsskr Nor Laegeforen 132:1330-4. 2012
    ..The population attributable risk was 27 %. In a nested case-control study we have updated the risk estimates for hormone replacement therapy in post-menopausal women since 2002...
  80. ncbi Proliferation of endothelial and tumor epithelial cells by progestin-induced vascular endothelial growth factor from human breast cancer cells: paracrine and autocrine effects
    Yayun Liang
    Dalton Cardiovascular Research Center and Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Endocrinology 146:3632-41. 2005
    ..We have previously shown that natural and synthetic progestins, including those used in hormone replacement therapy and oral contraception, induce the synthesis and secretion ..
  81. ncbi Treatment of non-atypic endometrial hyperplasia using thermal balloon endometrial ablation therapy
    Ilkka Y Järvelä
    Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland
    Gynecol Obstet Invest 59:202-6. 2005
    Traditionally endometrial hyperplasias have been treated with progestins. Unfortunately, quite often hyperplasias are resistant to treatment, or they recur after therapy...
  82. ncbi Upregulation of protein S by progestins
    Q Hughes
    Department of Haematology, Royal Perth Hospital, Perth, WA, Australia
    J Thromb Haemost 5:2243-9. 2007
    ..This contrasts with the reduction in PS levels observed in users of combined oral contraceptives, which contain both a progestin and an estrogen...
  83. ncbi Oral contraceptives vs injectable progestin in their effect on sexual behavior
    Jonathan A Schaffir
    Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Am J Obstet Gynecol 203:545.e1-5. 2010
    ..We sought to compare sexual function and hormone concentrations in combined oral contraceptive (COC) and injectable progestin users...
  84. ncbi Relation of androgen receptor sensitivity and mood to sexual desire in hormonal contraception users
    Els Elaut
    Department of Sexology and Gender Problems, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Contraception 85:470-9. 2012
    ....
  85. pmc Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins
    H Ma
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Proc Natl Acad Sci U S A 96:11161-6. 1999
    ..By contrast, 20alpha-HSD catalyzes the inactivation of progestins in the ovary and placenta by converting progesterone to 20alpha-hydroxyprogesterone, where progesterone is ..
  86. ncbi Use of oral contraceptives and breast cancer risk: The Norwegian-Swedish Women's Lifestyle and Health Cohort Study
    Merethe Kumle
    Institute of Community Medicine, University of Tromsoe, 9037 Tromsoe, Norway
    Cancer Epidemiol Biomarkers Prev 11:1375-81. 2002
    ..005). Current/recent use of OCs is associated with an increased breast cancer risk. Use of combined OCs and progestin-only pills seem to increase the risk at the same level...
  87. ncbi RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis
    Eva Gonzalez-Suarez
    Department of Hematology Oncology Research, Amgen Inc, Seattle, Washington 98119, USA
    Nature 468:103-7. 2010
    ..The current study highlights a potential role for RANKL inhibition in the management of proliferative breast disease...
  88. ncbi Interaction of progestins with the human multidrug resistance-associated protein 2 (MRP2)
    Heike Lindenmaier
    Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany
    Drug Metab Dispos 33:1576-9. 2005
    b>Progestins are widely used as oral contraceptives and hormone replacement therapy. Recently it has been demonstrated that many progestins are inhibitors of P-glycoprotein, possibly explaining gender differences in drug actions...
  89. ncbi Progestin therapy for endometrial cancer: the potential of fourth-generation progestin (review)
    Kouji Banno
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
    Int J Oncol 40:1755-62. 2012
    ..in vitro of endometrial cancer-derived cell lines which failed to respond to other progestins such as medroxyprogesterine acetate (MPA)...
  90. ncbi Up-regulation of nuclear receptor corepressor (NCoR) in progestin-induced growth suppression of endometrial hyperplasia and carcinoma
    Hiroyasu Kashima
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Anticancer Res 29:1023-9. 2009
    Although progestins have been used for the treatment of endometrial neoplasias, the mechanisms of progestin-induced growth suppression remain undetermined.
  91. ncbi Chronic hypoxia impairs gamete maturation in Atlantic croaker induced by progestins through nongenomic mechanisms resulting in reduced reproductive success
    Peter Thomas
    University of Texas at Austin, Marine Science Institute, 750 Channel View Drive, Port Aransas, Texas 78373, USA
    Environ Sci Technol 43:4175-80. 2009
    ..The results suggestthat nongenomic progestin signaling controlling the final stages of the reproductive cycle in fish is impaired under hypoxic conditions...
  92. ncbi Concentrations of progesterone and the 5 alpha-reduced progestins, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one, in luteal tissue and circulating blood and their relationship to luteal function in the African elephant, Loxodonta
    J K Hodges
    Department of Reproductive Biology, German Primate Centre, Gottingen, Germany
    Biol Reprod 56:640-6. 1997
    ..5 alpha-DHP) and 3 alpha-hydroxy-5 alpha-pregnan-20-one (5 alpha-P-3 alpha-OH) are the principal progestins biosynthesized by the African elephant corpus luteum...
  93. ncbi Managing cancer-related anorexia/cachexia
    G Mantovani
    Department of Medical Oncology, University of Cagliari, Italy
    Drugs 61:499-514. 2001
    ..There is an ongoing need for quality of life questionnaires which specifically address the most significant symptoms present in patients with CAC...
  94. ncbi Progesterone induces apoptosis in TRAIL-resistant ovarian cancer cells by circumventing c-FLIPL overexpression
    Viqar Syed
    Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Biochem 102:442-52. 2007
    ..In the present study, we evaluated the prospect of utilizing progestins in combination with TRAIL to enhance cell death in TRAIL-sensitive (OVCA 420, OVCA 429, and OVCA 433) and -..
  95. ncbi Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas
    M E Balañá
    Instituto de Biología y Medicina Experimental IBYME, Buenos Aires, Argentina
    Oncogene 18:6370-9. 1999
    ..These results provide the first evidence of interactions between progestins and HRB/ErbB signal transduction pathways in mammary cancer and the first demonstration that IGF-IR is required ..
  96. ncbi Subchorionic hemorrhage treatment with dydrogesterone
    Dimitrie Pelinescu-Onciul
    Clinica de Obstetrica Ginecologie, Filantropia University Hospital, Bucharest, Romania
    Gynecol Endocrinol 23:77-81. 2007
    ..In conclusion, the marked immunomodulatory effect of dydrogesterone in maintaining a T helper-2 cytokine balance means that it is a good choice for preventing abortion in women suffering from subchorionic hemorrhage...
  97. ncbi The antiproliferative effects of progestins in T47D breast cancer cells are tempered by progestin induction of the ETS transcription factor Elf5
    H N Hilton
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    Mol Endocrinol 24:1380-92. 2010
    ..prolactin-induced ETS transcription factor that specifies the mammary secretory cell lineage, is also induced by progestins in breast cancer cells via a direct mechanism...
  98. ncbi Pharmacokinetics and potency of progestins used for hormone replacement therapy and contraception
    Frank Z Stanczyk
    Department of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Rev Endocr Metab Disord 3:211-24. 2002
  99. ncbi Postmenopausal estrogen and progestin use in relation to breast cancer risk
    Polly A Newcomb
    University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53706, USA
    Cancer Epidemiol Biomarkers Prev 11:593-600. 2002
    ..09; 95% CI, 1.07-4.07 for ever use versus nonuse). Estrogen-progestin use, both sequential and continuous, appears to be more strongly associated with risk of breast cancer than use of estrogen alone...
  100. ncbi Dydrogesterone in threatened miscarriage: a Malaysian experience
    Ramachandhiran Udayar Pandian
    Department of Obstetrics and Gynaecology, Seberang Jaya Hospital, Seberang Jaya, Penang, Malaysia pandian
    Maturitas 65:S47-50. 2009
    ..Threatened miscarriage is a common problem during pregnancy...

Research Grants63

  1. INTERACTION OF THE ESTROGEN RECEPTOR WITH DNA
    ANN NARDULLI; Fiscal Year: 2013
    ..and apurinic endonuclease 1 (APE1) in the cerebral cortex of C57BL/6 mice, (2) define whether estrogens and/or progestins alter the expression of oxidative stress proteins in the cerebral cortex using organotypic brain slice cultures, ..
  2. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..Currently only estrogens alone or in combination with progestins or androgens are available to treat these conditions, including natural or surgical menopause...
  3. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..Current therapies include estrogen or hormone (estrogens + progestins) therapies (ERT and HRT), clonidine, the selective serotonin and/or norepinephrine reuptake inhibitors, and ..
  4. PROGESTIN AND GROWTH FACTOR CROSS-TALK IN BREAST CANCER
    CAROL ANN LANGE; Fiscal Year: 2010
    ..association of unliganded PRs and greatly potentiates PR transcriptional activity in the absence and presence of progestins. Paradoxically, these events are also required for nuclear export and rapid downregulation of liganded PRs by ..
  5. Mechanisms for the evolution of novel DNA specificity in a transcription factor f
    Joseph W Thornton; Fiscal Year: 2013
    ..The resulting structure-function knowledge will facilitate efforts to engineer TFs with new DNA-binding specificities in synthetic biology and biomedicine. ..
  6. Cellular Mechanisms for the hormonal Modulation of Sleep
    Jessica Mong; Fiscal Year: 2009
    ..Studies from a number of different species, including humans, suggest that sex hormones (estrogens, progestins and androgens) influence the physiology and pathology of sleep...
  7. Impact of Pregnancy on Drug Absorption, Disposition and End Organ Response
    Steve N Caritis; Fiscal Year: 2013
    ..In this application, we propose to study the pharmacology of vaginal progestins used in pregnant women with a short cervix...
  8. GHSU/WSU Cooperative Reproductive Medicine Network
    Michael Peter Diamond; Fiscal Year: 2013
    ..dramatically decreased conception and live birth rates, compared to anovulatory women not treated with progestins. In view of this clear-cut observation, an innovative studv has been designed to capitalize on it...
  9. Regulation of CD4+ T cell responses by a progesterone receptor
    Grant Hughes; Fiscal Year: 2013
    ..Natural and synthetic progestins bind with variable affinities to these 2 receptors...
  10. Role of Phospho-Progesterone Receptors (PR) in Hormone Refractory Breast Cancer
    CAROL ANN LANGE; Fiscal Year: 2013
    ..is transcriptionally hyperactive and remarkably, targets genes that are not sensitive to progesterone or progestins;IRS-1 is an example of a ligand-independent phospho-PR gene...
  11. Rat Models for Sex Steroid Action
    Michael J Soares; Fiscal Year: 2013
    ..Estrogens and progestins are key hormones affecting the physiology of the entire organism...
  12. Fetal Brain Damage: A Placental Disorder
    ANNA PENN; Fiscal Year: 2009
    ..Both established hormones, such as progestins and oxytocin, and hormones that we have recently identified as neuromodulators made by the placenta, such as ..
  13. NEURAL REGULATION OF PREPARTUM CERVICAL RIPENING
    Steven M Yellon; Fiscal Year: 2013
    ....
  14. Sex Differences in Protective Immunity Against Influenza A Viruses
    Sabra L Klein; Fiscal Year: 2011
    ..If protective heterosubtypic immunity is elevated in females compared with males, then estrogens and/or progestins may enhance and androgens may suppress adaptive immunity against heterosubtypic influenza A virus challenge...
  15. TRANSPORTERS IN METFORMIN TREATMENT OF ENDOMETRIAL HYPERPLASIA
    Dhiren R Thakker; Fiscal Year: 2013
    ..However, side effects of progestins include increased appetite and weight gain which are particularly detrimental in a population prone to obesity ..
  16. Identification of novel phytoprogestins from hops and red clover
    Joanna E Burdette; Fiscal Year: 2011
    ..Considerable evidence now indicates that the addition of synthetic progestins to HRT increases the risk of breast cancer as well as many other deleterious side effects...
  17. Gonadotropins &Cox-2 in Ovarian Cancer Prevention
    XIANGXI MIKE XU; Fiscal Year: 2013
    ..ovarian cancer etiology related to reproductive factors and the roles and mechanisms of Cox-1, Cox-2, uPA, and progestins (oral contraceptives), which are potential preventive targets/agents for ovarian cancer...
  18. Hormones and Tumor Initiating Cells in Human Breast Cancers
    CAROL ANN SARTORIUS; Fiscal Year: 2013
    ..The latter cells are negative for estrogen and progesterone receptors, and increase several fold in number with progestins, used in birth control and hormone therapy...
  19. Examining the cell cycle-dependence of progesterone receptor activity
    LINDSEY STARR TREVINO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Recent studies have suggested that progestins play a role in the etiology of breast cancer;however, the mechanisms by which progestins promote tumor formation/progression have not been defined...
  20. Oral contraceptive use by formulation and breast cancer risk by subtype
    DIANA SM BUIST; Fiscal Year: 2010
    ..changes in OC formulations over time including a reduction in estrogen dose and the inclusion of new synthetic progestins. Given the varying estrogenic, progestational, and androgenic activities of different synthetic progestins, it ..
  21. Biochemical and pharmacological studies of human membrane progesterone receptors
    Stephen G Chamberlin; Fiscal Year: 2013
    ..Molecules that mimic or modulate the effects of progesterone (progestins and antiprogestins) in biological systems are of significant pharmaceutical importance, being most commonly used ..
  22. Progestin Effects on Uterine Hemostatis &Angiogenesis
    Charles Lockwood; Fiscal Year: 2011
    ..will be studied in endometrial stromal cell and endothelial cell cultures and co-cultures exposed to progestins with or without hypoxia, ROS or thrombin...
  23. Effect of sex hormones on HIV infection of cervical and rectal mucosal tissue
    Natalia Teleshova; Fiscal Year: 2013
    ..We hypothesize that increased progestins/progesterone levels are associated with increased susceptibility of ecto-, endocervical and rectosigmoid mucosa ..
  24. Role of Allopregnanolone in Mediating the Adverse Effects of Psychosocial Stress
    Vasiliki Michopoulos; Fiscal Year: 2010
    ..Studying the mechanisms by which psychosocial stress disrupts the actions of ovarian hormones will speak to the development of anxiety-based psychopathology in women. ..
  25. Mechanisms of Progesterone Receptor Action
    Kathryn B Horwitz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This renewal continues research on estrogens (E) and progestins (P) in luminal, estrogen (ER) and progesterone (PR) receptor-positive human breast cancer...
  26. Mechanisms of Prevention of Ovarian Cancer by Oral Contraceptives
    Malcolm C Pike; Fiscal Year: 2013
    ..Exposure to progestins is higher while on OCs than in normal cycling and this could explain the protective effect...
  27. Evaluation of the immunologic and genital tract changes among Malawian women
    Jennifer Tang; Fiscal Year: 2013
    ..Understanding the potential association between progestins (such as medroxyprogesterone or levonorgestrel) and HIV acquisition is currently a critical research priority ..
  28. Progestins' non-genomic actions for socio-sexual behavior
    Cheryl Frye; Fiscal Year: 2009
    ..abstract_text> ..
  29. Dietary and Environmental Exposure to Cadmium and the Risk of Endometrial Cancer
    Rudolph P Rull; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Exposure to high levels of circulating estrogens unopposed by progestins is the primary cause of endometrial cancer...
  30. Cooperative Contraceptive Research Center: New Contraceptives with Dual Benefits
    REGINE SITRUK WARE; Fiscal Year: 2013
    ..We will: SA3: evaluate the mechanism of action of MENT when combined with progestins;SA4: evaluate the protective effect of MENT on Leydig Cells;SA5: confirm protective effects of MENT on bone when ..
  31. Kinetic and structural analysis of human steroid 5beta-reductase (AKR1D1)
    Mo Chen; Fiscal Year: 2012
    ..AKR1D1 also inactivates androgens, progestins and glucocorticoids and initiates steroid hormone clearance...
  32. Novel Mechanistic Targets of Steroid Hormones in the Brain
    Meharvan Singh; Fiscal Year: 2013
    ..to steroid hormones, suggesting the concept of a finite therapeutic window of opportunity for estrogens and/or progestins. During the first period (4 years) of funding, this Program Project sought to identify and characterize new and ..
  33. ER-Negative, Basal Cells Persist in Luminal Cancers: Are They Cancer Stem Cells?
    James M Haughian; Fiscal Year: 2011
    ..These studies also provide a plausible explanation for why women taking progestins in hormone replacement therapy (HRT) were at a higher risk of getting breast cancer...
  34. Influence of AKT pathway on progesterone receptor function in endometrial cancer
    JI YONG JULIE KIM; Fiscal Year: 2013
    ..However, the effectiveness of progestins for women with endometrial cancer is less clear...
  35. Uterine Leiomyoma Research Center Program
    Serdar E Bulun; Fiscal Year: 2013
    ..Project I (Bulun) will be pursued to understand the mechanisms as to how antl-progestins such as RU486 reduce tumor size...
  36. CHEMICAL SYNTHESIS FACILITY
    Bashir Kaskar; Fiscal Year: 2012
    ..abstract_text> ..
  37. CHEMICAL SYNTHESIS FACILITY
    Bashir Kaskar; Fiscal Year: 2013
    ..abstract_text> ..
  38. The pharmacological actions of antiprogestins in uterine fibroids
    Donald P McDonnell; Fiscal Year: 2010
    ..to evaluate the role(s) of specific coactivators and corepressors in mediating the biological responses to progestins and antiprogestins in cellular models of uterine fibroids and relate these findings to the biology of fibroids...
  39. BRAIN MECHANISMS OF REPRODUCTIVE BEHAVIOR
    Donald W Pfaff; Fiscal Year: 2012
    ..For the first time in mice, the relative importance of estrogens (E), progestins (P) and their combination will be explored...
  40. Prevention of HIV transmission/acquisition through informed contraceptive choice
    Danny J Schust; Fiscal Year: 2013
    ..Accordingly, we seek an improved knowledge of the effects of contraceptive progestins on HIV-1 transmission...
  41. ENDOMETRIAL VEGF: ENDOCRINE REGULATION OF ANGIOGENESIS
    Robert Taylor; Fiscal Year: 1999
    ..normal menses, which is triggered by spiral artery constriction, irregular bleeding associated with parenteral progestins is thought to originate from the subepithelial capillary plexus...
  42. MOLECULAR STRUCTURE OF STEROIDS
    William Duax; Fiscal Year: 2001
    ..model for steroid hormone receptor binding and activity, revealed unanticipated conformations of the most potent progestins, estrogens and corticoids, and produced 164 manuscripts, 34 chapters and two volumes of the Atlas of Steroid ..
  43. MECHANISMS OF INFERTILITY IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2002
    ..resistance in endometriosis, which is also confirmed clinically by resistance of this disease to treatment with progestins. Results of our preliminary findings, however, can only be interpreted with caution, since the models used were ..
  44. EVALUATION OF THE PHARMACOKINETIC PROFILE, EFFECTS ON THE MECHANISMS
    ERIN ALLEN; Fiscal Year: 2013
    ..has had the longest and widest history of providing effective contraception in a variety of formulations, newer progestins such as desogestrel and Nestorone may provide safe and effective contraception with improved bleeding patterns ..
  45. RECEPTOR MEDIATED RADIATION ONCOLOGY
    WILLIAM BLOOMER; Fiscal Year: 1991
    ..We will synthesize position specific, carrier-free 125-I-labeled estrogens and progestins with high receptor affinity, prolonged nuclear retention time and low non-specific binding...
  46. ECTOPY, HORMONAL CONTRACEPTION AND STD'S IN ADOLESCENTS
    Ligia Peralta; Fiscal Year: 2004
    ..the transformation zone (T zone) in sexually active adolescents, 2) the impact of DMPA and a combined estrogen-progestins (OC) over time on cervical ectopy/T zone; 3) the relation between the size of the area of ectopy/T zone and STD ..
  47. PSYCHOBIOLOGY OF ESTROGEN RECEPTOR MODULATORS
    Mark Wilson; Fiscal Year: 2003
    ..in hypo- estrogenic women, such treatments may adversely affect the breast uterus, despite co-treatment with progestins. Consequently, non-steroidal estrogens have been developed with specific targeted effects as E2 agonists in some ..
  48. Progestin Actions in the Primate Breast and Uterus
    Charles Wood; Fiscal Year: 2009
    ..women's health at this time is whether these adverse effects are specific to MPA or characteristic of all progestins. Given the diverse and in some cases opposing cellular actions of different progestin types, it is likely that ..
  49. RISK FACTORS FOR INTRACRANIAL MENINGIOMA
    Wt Longstreth; Fiscal Year: 1999
    ..increased by exposure to ionizing radiation (chiefly dental x-rays), to endogenous and exogenous estrogens and progestins, and to prior head trauma...
  50. HORMONAL CONTROL OF FEMALE REPRODUCTIVE TRACT GROWTH
    Robert Bigsby; Fiscal Year: 1991
    ..In two models of estrogen-independent uterine epithelial growth, progestins and glucocorticoids inhibit DNA synthesis...
  51. Progesterone Treatment for Cocaine-Dependent Women
    Suzette Evans; Fiscal Year: 2009
    ..Oral micronized progesterone, as opposed to synthetic progestins, has a high safety profile and can be administered to women for prolonged periods, with the most common side ..
  52. METABOLIC TRANSFORMATION OF STEROIDS IN BREAST CELLS
    Rajeshwari Mehta; Fiscal Year: 1992
    ..Tissue levels of steroids (estrogen, progestins, androgen) and the factors produced by malignant tumor cells appear to regulate the local interconversion of ..
  53. GENETIC DISSECTION OF PROGESTERONE RECEPTOR FUNCTION
    Donald McDonnell; Fiscal Year: 2004
    The classical models of progesterone action held that the biological activities of progestins and antiprogestins are mediated through a specific high-affinity receptor protein located in the nuclei of target cells...
  54. ANDROGEN BIOLOGY TO FETAL LUNG DEVELOPMENT
    John Torday; Fiscal Year: 1999
    ..anti- androgen progesterone to reverse the inhibition of glucocorticoid- stimulated surfactant production, since progestins can safely be used in human pregnancy...
  55. Sex Hormone Regulation of Innate Immunity in Women & Men
    Charles Wira; Fiscal Year: 2006
    The overall objective of this Program Project is to define the role of sex hormones (androgens, estrogens and progestins) in regulating the innate immune system as it functions systemically and at mucosal surfaces...
  56. Hormone Replacement and Cerebral Glucose Metabolism
    John Woodard; Fiscal Year: 2000
    ..serum estradiol levels have been associated with better memory performance, although there is also evidence that progestins may actually attenuate or reverse many cognitive benefits of estrogens...
  57. Progestin Levels and Inflammation in Postmenopause
    Peifeng Hu; Fiscal Year: 2007
    ..progestin to coronary heart disease and has not accounted for the post-treatment variability in serum levels of progestins resulting from medication compliance or differences in medication absorption and metabolism...
  58. HORMONE-ACTION AND CYTOKINE REGULATION OF DECIDUA CELLS
    CHARLES CHAFFIN; Fiscal Year: 2003
    ..Our goal is to lower the threshold for apoptosis by ovariectomy (Ovx), administration of anti-progestins and phorbol esters by enhancing PKC activity...
  59. STEROID DYNAMICS IN ENDOCRINOLOGY
    ERLIO GURPIDE; Fiscal Year: 1991
    ..Hormonal regulation of endometrial prostaglandin (PG production and the mechanisms by which estrogens, progestins and glucocorticoids exert their actions on PGF2 output will be studied by comparing responses of epithelial and ..
  60. Female Sex Hormones and Spinal Injury
    David Fuller; Fiscal Year: 2006
    ..Although endogenous estrogens and progestins promote recovery following traumatic brain injury, their impact on motor recovery after SCI is unknown...
  61. Endocrine and Growth Factor Regulation in the Pituitary
    PAMELA MELLON; Fiscal Year: 2005
    ..cell lines that express FSH, LH, activin, follistatin, and the receptors for GnRH, activin, androgens, progestins, and glucocorticoids...
  62. INHIBITION OF PROGESTIN-DEPENDENT ANGIOGENESIS IN BREAST CANCER
    CANDACE CARROLL; Fiscal Year: 2009
    ..an intact uterus are prescribed combined hormone replacement therapy (HRT), consisting of both estrogens and progestins, to diminish menopausal symptoms;progestins negate the proliferative effects of estrogens in the uterus, which ..
  63. Interaction of FOXO1 and Progesterone Receptor in Endometrial Cancer
    Ji Yong Kim; Fiscal Year: 2009
    ..However, the effectiveness of progestins for women with endometrial cancer, is less clear...