oxytocin

Summary

Summary: A nonapeptide posterior pituitary hormone that causes UTERINE CONTRACTIONS and stimulates MILK EJECTION.

Top Publications

  1. ncbi Oxytocin increases trust in humans
    Michael Kosfeld
    University of Zurich, Institute for Empirical Research in Economics, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Nature 435:673-6. 2005
  2. ncbi Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, D 68159 Mannheim, Germany
    Nat Rev Neurosci 12:524-38. 2011
  3. ncbi Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Front Neuroendocrinol 25:150-76. 2004
  4. ncbi Oxytocin, vasopressin, and the neurogenetics of sociality
    Zoe R Donaldson
    Center for Behavioral Neuroscience, Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Science 322:900-4. 2008
  5. ncbi The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans
    Kai MacDonald
    Department of Psychiatry, University of California, San Diego, CA, USA
    Harv Rev Psychiatry 18:1-21. 2010
  6. ncbi Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients
    David Feifel
    Department of Psychiatry, University of California, San Diego Medical Center, San Diego, California 92103 8218, USA
    Biol Psychiatry 68:678-80. 2010
  7. ncbi The oxytocin receptor system: structure, function, and regulation
    G Gimpl
    Institut fur Biochemie, Johannes Gutenberg Universitat, Mainz, Germany
    Physiol Rev 81:629-83. 2001
  8. ncbi Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
    Thomas Baumgartner
    Center for the Study of Social and Neural Systems, Institute for Empirical Research in Economics, University of Zurich, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Neuron 58:639-50. 2008
  9. ncbi Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci 30:4999-5007. 2010
  10. pmc The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 65:768-79. 2010

Detail Information

Publications326 found, 100 shown here

  1. ncbi Oxytocin increases trust in humans
    Michael Kosfeld
    University of Zurich, Institute for Empirical Research in Economics, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Nature 435:673-6. 2005
    ..Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a ..
  2. ncbi Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
    Andreas Meyer-Lindenberg
    Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, D 68159 Mannheim, Germany
    Nat Rev Neurosci 12:524-38. 2011
    The neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are evolutionarily highly conserved mediators in the regulation of complex social cognition and behaviour...
  3. ncbi Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
    Rainer Landgraf
    Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Front Neuroendocrinol 25:150-76. 2004
    As exemplified particularly with vasopressin and oxytocin, release of neuropeptides within the brain occurs from dendrites, somata, and axons of neurosecretory neurons; mechanisms include activation of intracellular Ca2+ stores, changed ..
  4. ncbi Oxytocin, vasopressin, and the neurogenetics of sociality
    Zoe R Donaldson
    Center for Behavioral Neuroscience, Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Science 322:900-4. 2008
    There is growing evidence that the neuropeptides oxytocin and vasopressin modulate complex social behavior and social cognition...
  5. ncbi The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans
    Kai MacDonald
    Department of Psychiatry, University of California, San Diego, CA, USA
    Harv Rev Psychiatry 18:1-21. 2010
    b>Oxytocin is a neuropeptide involved in a wide variety of social behaviors in diverse species. Recent research on its effects in humans has generated an arresting picture of its role in the dynamic function of the social brain...
  6. ncbi Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients
    David Feifel
    Department of Psychiatry, University of California, San Diego Medical Center, San Diego, California 92103 8218, USA
    Biol Psychiatry 68:678-80. 2010
    Both human and animal studies suggest oxytocin may have antipsychotic properties. Therefore, we conducted a clinical trial to directly test this notion.
  7. ncbi The oxytocin receptor system: structure, function, and regulation
    G Gimpl
    Institut fur Biochemie, Johannes Gutenberg Universitat, Mainz, Germany
    Physiol Rev 81:629-83. 2001
    The neurohypophysial peptide oxytocin (OT) and OT-like hormones facilitate reproduction in all vertebrates at several levels...
  8. ncbi Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
    Thomas Baumgartner
    Center for the Study of Social and Neural Systems, Institute for Empirical Research in Economics, University of Zurich, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Neuron 58:639-50. 2008
    ..Recent behavioral evidence shows that the neuropeptide oxytocin increases trust among humans, thus offering a unique chance of gaining a deeper understanding of the neural ..
  9. ncbi Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci 30:4999-5007. 2010
    b>Oxytocin (OT) is becoming increasingly established as a prosocial neuropeptide in humans with therapeutic potential in treatment of social, cognitive, and mood disorders...
  10. pmc The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior
    Thomas R Insel
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 65:768-79. 2010
    ..This review follows the trail of research on oxytocin and vasopressin as an exemplar of one path for exploring the "dark matter" of social neuroscience...
  11. ncbi Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
    Nadine Striepens
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Front Neuroendocrinol 32:426-50. 2011
    There has been unprecedented interest in the prosocial effects of the neuropeptide oxytocin in humans over the last decade...
  12. pmc Peripheral oxytocin is associated with reduced symptom severity in schizophrenia
    Leah H Rubin
    Department of Psychiatry, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Schizophr Res 124:13-21. 2010
    Emerging evidence from clinical trials suggests that oral estrogen and intranasal oxytocin might reduce symptom severity in schizophrenia. Whether increases in endogenous hormones are similarly associated with improved symptoms is unknown...
  13. pmc Promoting social behavior with oxytocin in high-functioning autism spectrum disorders
    Elissar Andari
    Centre de Neuroscience Cognitive, Unité Mixte de Recherche 5229, Centre National de la Recherche Scientifique, 69675 Bron, France
    Proc Natl Acad Sci U S A 107:4389-94. 2010
    ..Recently, it has been suggested that oxytocin, a hormone known to promote mother-infant bonds, may be implicated in the social deficit of autism...
  14. ncbi Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
    Markus Heinrichs
    Department of Clinical Psychology, University of Zurich, Zurich, Switzerland
    Biol Psychiatry 54:1389-98. 2003
    ..Recent animal studies suggest that the neuropeptide oxytocin is implicated both in prosocial behavior and in the central nervous control of neuroendocrine responses to stress...
  15. ncbi Oxytocin modulates neural circuitry for social cognition and fear in humans
    Peter Kirsch
    Cognitive Neuroscience Group, Center for Psychiatry and Psychotherapy, Justus Liebig University, D 35385 Giessen, Germany
    J Neurosci 25:11489-93. 2005
    In non-human mammals, the neuropeptide oxytocin is a key mediator of complex emotional and social behaviors, including attachment, social recognition, and aggression...
  16. pmc Oxytocin: the great facilitator of life
    Heon Jin Lee
    Section on Neural Gene Expression, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
    Prog Neurobiol 88:127-51. 2009
    b>Oxytocin (Oxt) is a nonapeptide hormone best known for its role in lactation and parturition...
  17. pmc Oxytocin/vasopressin-related peptides have an ancient role in reproductive behavior
    Jennifer L Garrison
    Howard Hughes Medical Institute, Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA
    Science 338:540-3. 2012
    ..Vasopressin and oxytocin neuropeptides are strongly implicated in mammalian reproductive and social behaviors, yet rodent loss-of-function ..
  18. ncbi Neuromodulation by oxytocin and vasopressin
    Ron Stoop
    Centre for Psychiatric Neurosciences, Lausanne University Hospital Center, Lausanne, Switzerland
    Neuron 76:142-59. 2012
    b>Oxytocin (OT) and vasopressin (VP) are two closely related neuropeptides, widely known for their peripheral hormonal effects...
  19. ncbi Social effects of oxytocin in humans: context and person matter
    Jennifer A Bartz
    Mount Sinai School of Medicine, Seaver Autism Center, Department of Psychiatry, New York, New York, 10029, USA
    Trends Cogn Sci 15:301-9. 2011
    Building on animal research, the past decade has witnessed a surge of interest in the effects of oxytocin on social cognition and prosocial behavior in humans...
  20. pmc Oxytocin and the development of parenting in humans
    Ilanit Gordon
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel Gonda Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    Biol Psychiatry 68:377-82. 2010
    The nonapeptide oxytocin (OT) has been repeatedly implicated in processes of parent-infant bonding in animal models; yet, its role in the development of human parenting has received less attention and no research has addressed the ..
  21. ncbi The contributions of oxytocin and vasopressin pathway genes to human behavior
    Richard P Ebstein
    Department of Psychology, National University of Singapore, Singapore
    Horm Behav 61:359-79. 2012
    Arginine vasopressin (AVP) and oxytocin (OXT) are social hormones and mediate affiliative behaviors in mammals and as recently demonstrated, also in humans...
  22. ncbi Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Sydney, NSW 2050, Australia
    Biol Psychiatry 67:692-4. 2010
    ..Deficits in the ability to recognize the emotions of others are believed to contribute to this. There is currently no effective treatment for these problems...
  23. ncbi The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans
    Carsten K W De Dreu
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
    Science 328:1408-11. 2010
    ..Here, we have linked oxytocin, a neuropeptide produced in the hypothalamus, to the regulation of intergroup conflict...
  24. ncbi Oxytocin, vasopressin, and human social behavior
    Markus Heinrichs
    Department of Psychology, University of Freiburg, Freiburg i Br, Germany
    Front Neuroendocrinol 30:548-57. 2009
    There is substantial evidence from animal research indicating a key role of the neuropeptides oxytocin (OT) and arginine vasopressin (AVP) in the regulation of complex social cognition and behavior...
  25. ncbi Effects of intranasal oxytocin on emotional face processing in women
    Gregor Domes
    Department of Psychology, University of Freiburg, D 79104 Freiburg, Germany
    Psychoneuroendocrinology 35:83-93. 2010
    The neuropeptide oxytocin (OXT) has previously been found to reduce amygdala reactivity to social and emotional stimuli in healthy men...
  26. ncbi Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders
    Eric Hollander
    Department of Psychiatry, Seaver Autism Research Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 28:193-8. 2003
    ..There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, in autism spectrum patients...
  27. pmc Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression
    Marta Skrundz
    sesam Swiss Etiological Study of Adjustment and Mental Health National Centre of Competence in Research, Faculty of Psychology, University of Basel, Basel, Switzerland
    Neuropsychopharmacology 36:1886-93. 2011
    Postpartum depression (PPD) affects up to 19% of all women after parturition. The non-apeptide oxytocin (OXT) is involved in adjustment to pregnancy, maternal behavior, and bonding...
  28. ncbi Oxytocin modulates amygdala, insula, and inferior frontal gyrus responses to infant crying: a randomized controlled trial
    Madelon M E Riem
    Centre for Child and Family Studies, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
    Biol Psychiatry 70:291-7. 2011
    b>Oxytocin facilitates parental caregiving and mother-infant bonding and might be involved in responses to infant crying...
  29. pmc Oxytocin can hinder trust and cooperation in borderline personality disorder
    Jennifer Bartz
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1230, New York, NY 10029, USA
    Soc Cogn Affect Neurosci 6:556-63. 2011
    We investigated the effects of intranasal oxytocin (OXT) on trust and cooperation in borderline personality disorder (BPD), a disorder marked by interpersonal instability and difficulties with cooperation...
  30. ncbi Sharing secrets: oxytocin and trust in schizophrenia
    Szabolcs Keri
    Department of Psychiatry and Psychotherapy, Semmelweis University, Balassa u 6, Budapest H1083, Hungary
    Soc Neurosci 4:287-93. 2009
    Previous studies indicated that oxytocin plays an important role in human trust, which is impaired in patients with severe mental disorders...
  31. ncbi Maternal and paternal plasma, salivary, and urinary oxytocin and parent-infant synchrony: considering stress and affiliation components of human bonding
    Ruth Feldman
    Department of Psychology and the Gonda Brain Sciences Center, Bar Ilan University, Israel
    Dev Sci 14:752-61. 2011
    Studies in mammals have implicated the neuropeptide oxytocin (OT) in processes of bond formation and stress modulation, yet the involvement of OT in human bonding throughout life remains poorly understood...
  32. ncbi Oxytocin and cooperation under conditions of uncertainty: the modulating role of incentives and social information
    Carolyn H Declerck
    University of Antwerp, Faculty of Applied Economics, Antwerpen, Belgium
    Horm Behav 57:368-74. 2010
    The neuropeptide Oxytocin (OT) has been implicated in many aspects of mammalian social behavior. This study investigates how OT interacts with two well-studied determinants of cooperative behavior: incentives and social information...
  33. pmc Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits
    Morris Goldman
    Department of Psychiatry, University of Chicago, 5841 South Maryland, Chicago, IL 60637 USA
    Schizophr Res 98:247-55. 2008
    ..Neuroanatomic and electrophysiologic studies indicate oxytocin activity in PHS patients should also be affected...
  34. pmc Adult attachment predicts maternal brain and oxytocin response to infant cues
    Lane Strathearn
    Department of Pediatrics, The Meyer Center for Developmental Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, TX 77030, USA
    Neuropsychopharmacology 34:2655-66. 2009
    ..b>Oxytocin, a neurohormone of attachment, promotes maternal care in animals, although its role in human maternal behavior is ..
  35. ncbi Oxytocin improves "mind-reading" in humans
    Gregor Domes
    Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany
    Biol Psychiatry 61:731-3. 2007
    ..The neuropeptide oxytocin plays a central role in social approach behavior in nonhuman mammals.
  36. ncbi CD38 is critical for social behaviour by regulating oxytocin secretion
    Duo Jin
    Kanazawa University 21st Century COE Program on Innovative Brain Science on Development, Learning and Memory, Kanazawa 920 8640, Japan
    Nature 446:41-5. 2007
    ..Consistently, the plasma level of oxytocin (OT), but not vasopressin, was strongly decreased in CD38-/- mice...
  37. pmc Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder
    Izelle Labuschagne
    School of Psychology and Psychiatry, Monash University, Melbourne, Australia
    Neuropsychopharmacology 35:2403-13. 2010
    ..The neuropeptide oxytocin (OXT) decreases anxiety and stress, facilitates social encounters, and attenuates amygdala reactivity to ..
  38. pmc Oxytocin increases generosity in humans
    Paul J Zak
    Center for Neuroeconomics Studies and Department of Economics, Claremont Graduate University, Claremont, California, United States of America
    PLoS ONE 2:e1128. 2007
    ..In this study, participants were infused with 40 IU oxytocin (OT) or placebo and engaged in a blinded, one-shot decision on how to split a sum of money with a stranger that ..
  39. ncbi Oxytocin is associated with human trustworthiness
    Paul J Zak
    Center for Neuroeconomics Studies, Claremont Graduate University, Claremont, CA 91711 6165, USA
    Horm Behav 48:522-7. 2005
    Human beings exhibit substantial interpersonal trust-even with strangers. The neuroactive hormone oxytocin facilitates social recognition in animals, and we examine if oxytocin is related to trustworthiness between humans...
  40. pmc Oxytocin promotes human ethnocentrism
    Carsten K W De Dreu
    Department of Psychology, University of Amsterdam, 1018 WB, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 108:1262-6. 2011
    ..within-group trust, cooperation, and coordination, we conjecture that ethnocentrism may be modulated by brain oxytocin, a peptide shown to promote cooperation among in-group members...
  41. ncbi Evoked axonal oxytocin release in the central amygdala attenuates fear response
    H Sophie Knobloch
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany
    Neuron 73:553-66. 2012
    The hypothalamic neuropeptide oxytocin (OT), which controls childbirth and lactation, receives increasing attention for its effects on social behaviors, but how it reaches central brain regions is still unclear...
  42. ncbi Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes
    Katsuhisa Matsuura
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    J Biol Chem 279:11384-91. 2004
    ..A fraction of Sca-1+ cells stuck to the culture dish and proliferated slowly. When treated with oxytocin, Sca-1+ cells expressed genes of cardiac transcription factors and contractile proteins and showed sarcomeric ..
  43. ncbi Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes
    Ruth Feldman
    Department of Psychology and the Gonda Brain Sciences Center, Bar Ilan University, Ramat Gan, Israel
    Biol Psychiatry 72:175-81. 2012
    Research in mammals has demonstrated the involvement of oxytocin (OT) in social bond formation; yet, its role in human bonding remains unclear...
  44. ncbi A critical review of the influence of oxytocin nasal spray on social cognition in humans: evidence and future directions
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, 2050, Australia
    Horm Behav 61:410-8. 2012
    The past eight years of research has demonstrated that oxytocin nasal spray has a significant impact on human social cognition...
  45. pmc Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity
    Predrag Petrovic
    Wellcome Trust Functional Imaging Laboratory, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 28:6607-15. 2008
    Social relations between humans critically depend on our affective experiences of others. Oxytocin enhances prosocial behavior, but its effect on humans' affective experience of others is not known...
  46. pmc Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
    Matthias Gamer
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 107:9400-5. 2010
    The neuropeptide oxytocin enhances the processing of positive social stimuli and improves the capacity to effectively attend the eye region of conspecifics...
  47. pmc Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
    Suma Jacob
    Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, 1747 West Roosevelt Road, Chicago, IL 60608, USA
    Neurosci Lett 417:6-9. 2007
    The oxytocin receptor gene (OXTR) has been studied in autism because of the role of oxytocin (OT) in social cognition. Linkage has also been demonstrated to the region of OXTR in a large sample...
  48. ncbi More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women
    Kathleen C Light
    Department of Psychiatry, University of North Carolina, CB 7175 Medical Building A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 69:5-21. 2005
    In animals, ventral stroking for >5 days increases oxytocin (OT) activity and decreases blood pressure (BP), but related human studies are few...
  49. ncbi Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research
    Adam J Guastella
    Brain and Mind Research Institute, University of Sydney, Sydney 2006, Australia
    Psychoneuroendocrinology 38:612-25. 2013
    A series of studies have reported on the salubrious effects of oxytocin nasal spray on social cognition and behavior in humans, across physiology (e.g., eye gaze, heart rate variability), social cognition (e.g...
  50. pmc Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome
    Scott S Hall
    Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA 94305 5795, USA
    Psychoneuroendocrinology 37:509-18. 2012
    ..We investigated whether oxytocin (OT), a hormone with prosocial and anxiolytic effects, could alleviate symptoms of social anxiety in this ..
  51. ncbi Complex effects of imatinib on spontaneous and oxytocin-induced contractions in human non-pregnant myometrium
    S M Cretoiu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Acta Physiol Hung 98:329-38. 2011
    ..aim of this study was to investigate the effects of imatinib as a c-kit receptor antagonist on the spontaneous or oxytocin (OT) induced contractions of human non-pregnant myometrium in vitro...
  52. ncbi Integrative approaches utilizing oxytocin to enhance prosocial behavior: from animal and human social behavior to autistic social dysfunction
    Hidenori Yamasue
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Neurosci 32:14109-17. 2012
    ..the topics covered in our 2012 Society for Neuroscience Mini-Symposium entitled "Integrative Approaches Using Oxytocin to Enhance Prosocial Behavior: From Animal and Human Social Behavior to ASD's Social Dysfunction...
  53. ncbi Oxytocin and social affiliation in humans
    Ruth Feldman
    Department of Psychology and the Gonda Brain Sciences Center, Bar Ilan University, Ramat Gan 52900, Israel
    Horm Behav 61:380-91. 2012
    ..Studies across multiple attachments throughout life are presented and demonstrate that the extended oxytocin (OT) system provides the neurohormonal substrate for parental, romantic, and filial attachment in humans; that ..
  54. pmc Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics
    M Manning
    Biochemistry and Cancer Biology, University of Toledo College of Medicine, Toledo, OH 43614 2598, USA
    J Neuroendocrinol 24:609-28. 2012
    ..agonists and antagonists for the V(1a), V(1b) and V(2) receptors for arginine vasopressin (AVP) and the oxytocin receptor for oxytocin (OT)...
  55. pmc Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta)
    Steve W C Chang
    Department of Neurobiology, Duke University School of Medicine, Durham, NC 27701, USA
    Proc Natl Acad Sci U S A 109:959-64. 2012
    ..b>Oxytocin (OT), a neurosecretory hormone synthesized by hypothalamic neurons in the mammalian brain, can enhance ..
  56. pmc Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E1898-908. 2012
    Animal data suggest that oxytocin is a satiety hormone...
  57. ncbi Oxytocin plasma concentrations after single intranasal oxytocin administration - a study in healthy men
    A Gossen
    Department of Psychiatry, RWTH Aachen University, and JARA Translational Brain Medicine, Aachen, Germany
    Neuropeptides 46:211-5. 2012
    The neuropeptide oxytocin has become a subject of great interest in studies investigating human social cognition...
  58. ncbi Oxytocin increases autonomic cardiac control: moderation by loneliness
    Greg J Norman
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Biol Psychol 86:174-80. 2011
    The current study examined the role of perceived social isolation in moderating the effects of oxytocin on cardiac autonomic control in humans...
  59. ncbi Plasma oxytocin distributions in a large cohort of women and men and their gender-specific associations with anxiety
    Omri Weisman
    Department of Psychology and the Gonda Brain Sciences Center Bar Ilan University, Ramat Gan 52900, Israel
    Psychoneuroendocrinology 38:694-701. 2013
    Research has consistently addressed the relations between plasma oxytocin (OT) - a nonapeptide implicated in mammalian social bonding - and psychological distress, but the direction of the association remains unclear...
  60. ncbi Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
    Inga D Neumann
    Department of Behavioral and Molecular Neurobiology, University of Regensburg, Regensburg, Germany
    Trends Neurosci 35:649-59. 2012
    b>Oxytocin and vasopressin are regulators of anxiety, stress-coping, and sociality...
  61. pmc Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner
    Tiffany M Love
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Biol Psychiatry 72:198-206. 2012
    b>Oxytocin, classically involved in social and reproductive activities, is increasingly recognized as an antinociceptive and anxiolytic agent, effects which may be mediated via oxytocin's interactions with the dopamine system...
  62. pmc No laughing matter: intranasal oxytocin administration changes functional brain connectivity during exposure to infant laughter
    Madelon M E Riem
    Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands
    Neuropsychopharmacology 37:1257-66. 2012
    ..The neuropeptide oxytocin might enhance the incentive salience of infant laughter by modulating neural circuits related to the perception ..
  63. pmc Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men
    James K Rilling
    Department of Anthropology, Emory University, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 37:447-61. 2012
    ..In this double-blind, placebo-controlled study, we investigate the impact of intranasally administered oxytocin (OT) and vasopressin (AVP) on behavior and brain activity among men in the context of an iterated Prisoner's ..
  64. ncbi Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
    James E Blevins
    VA Puget Sound Health Care System, Research Service 151 1660 S Columbian Wy, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 287:R87-96. 2004
    Hindbrain projections of oxytocin neurons in the parvocellular paraventricular nucleus (pPVN) are hypothesized to transmit leptin signaling from the hypothalamus to the nucleus of the solitary tract (NTS), where satiety signals from the ..
  65. ncbi Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
    Markus Heinrichs
    Department of Psychology, Clinical Psychology and Psychobiology, University of Zurich, Zurich, Switzerland
    Prog Brain Res 170:337-50. 2008
    ..In non-human mammals, the neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are key mediators of complex social behaviours, including attachment, social ..
  66. pmc The oxytocin system in drug discovery for autism: animal models and novel therapeutic strategies
    Meera E Modi
    Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Horm Behav 61:340-50. 2012
    ..Both genotype and phenotype based models have implicated the neuropeptide oxytocin (OT) in the regulation of social behavior...
  67. ncbi Oxytocin selectively gates fear responses through distinct outputs from the central amygdala
    Daniele Viviani
    Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital Center, University of Lausanne, CH 1015 Lausanne, Switzerland
    Science 333:104-7. 2011
    ..neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular ..
  68. ncbi Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent-infant contact
    Ruth Feldman
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Psychoneuroendocrinology 35:1133-41. 2010
    Animal studies have demonstrated that the neuropeptide oxytocin (OT) plays a critical role in processes of parent-infant bonding through mechanisms of early parental care, particularly maternal grooming and contact...
  69. ncbi Oxytocin modulates cooperation within and competition between groups: an integrative review and research agenda
    Carsten K W De Dreu
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, The Netherlands
    Horm Behav 61:419-28. 2012
    The author reviews evidence that hypothalamic release (or infusion) of the neuropeptide oxytocin modulates the regulation of cooperation and conflict among humans because of three reasons...
  70. ncbi Intranasal oxytocin administration attenuates the ACTH stress response in monkeys
    Karen J Parker
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94305 5485, USA
    Psychoneuroendocrinology 30:924-9. 2005
    ..Recent evidence suggests that oxytocin (OT), a neuropeptide involved in social bond formation, may play a role...
  71. ncbi Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade
    Kazuhito Tomizawa
    Department of Physiology, Okayama University Graduate School of Medicine and Dentistry, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Nat Neurosci 6:384-90. 2003
    b>Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood...
  72. pmc Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams
    M S McMurray
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Stress 11:398-410. 2008
    ..and decreased aggression in the cocaine-treated dams are correlated with either decreased or increased levels of oxytocin in the amygdala, respectively...
  73. ncbi Intranasal oxytocin reduces psychotic symptoms and improves Theory of Mind and social perception in schizophrenia
    Cort A Pedersen
    Department of Psychiatry CB 7160, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
    Schizophr Res 132:50-3. 2011
    b>Oxytocin has numerous prosocial and antipsychotic-like effects in animals. Prosocial effects of acute intranasal oxytocin administration have also been reported in human subjects...
  74. pmc No stress please! Mechanisms of stress hyporesponsiveness of the maternal brain
    David A Slattery
    Department of Behavioural and Molecular Neuroendocrinology, Institute of Zoology, University of Regensburg, Universitatsstrasse 31, D 93053 Regensburg, Germany
    J Physiol 586:377-85. 2008
    ..be a consequence of an increased activity of brain systems with inhibitory effects on the HPA axis (such as the oxytocin and prolactin systems) and of a reduced activity of excitatory pathways (noradrenaline (norepinephrine), ..
  75. ncbi Dendritic peptide release and peptide-dependent behaviours
    Mike Ludwig
    Laboratory of Neuroendocrinology, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Nat Rev Neurosci 7:126-36. 2006
    Neuropeptides that are released from dendrites, such as oxytocin and vasopressin, function as autocrine or paracrine signals at their site of origin, but can also act at distant brain targets to evoke long-lasting changes in behaviour...
  76. ncbi Oxytocin attenuates amygdala responses to emotional faces regardless of valence
    Gregor Domes
    Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
    Biol Psychiatry 62:1187-90. 2007
    b>Oxytocin is known to reduce anxiety and stress in social interactions as well as to modulate approach behavior. Recent studies suggest that the amygdala might be the primary neuronal basis for these effects.
  77. pmc Modulating social behavior with oxytocin: how does it work? What does it mean?
    Patricia S Churchland
    Philosophy Department, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0119, USA
    Horm Behav 61:392-9. 2012
    Among its many roles in body and brain, oxytocin influences social behavior...
  78. ncbi Divergent effects of two different doses of intranasal oxytocin on facial affect discrimination in schizophrenic patients with and without polydipsia
    Morris B Goldman
    Department of Psychiatry, Northwestern University, 446 East Ontario Suite 7 100, Chicago, IL 60611, USA
    Psychopharmacology (Berl) 216:101-10. 2011
    ..facial emotions has been linked to core features of schizophrenia and to diminished levels of the closely related hormone, oxytocin, in the polydipsic subset. Intranasal oxytocin enhances facial affect discrimination in healthy subjects.
  79. ncbi Two genetic variants of CD38 in subjects with autism spectrum disorder and controls
    Toshio Munesue
    Kanazawa University 21st Century Center of Excellence COE Program on Innovative Brain Science on Development, Learning and Memory, Kanazawa 920 8640, Japan
    Neurosci Res 67:181-91. 2010
    ..Given the role of CD38 in social recognition through oxytocin (OT) release, we hypothesized that CD38 may play a role in the etiology of ASD...
  80. ncbi Oxytocin administration attenuates stress reactivity in borderline personality disorder: a pilot study
    D Simeon
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine and Beth Israel Medical Center, 317 East 17th Street, New York, NY, USA
    Psychoneuroendocrinology 36:1418-21. 2011
    b>Oxytocin has known stress-reducing and attachment-enhancing effects. We thus hypothesized that oxytocin would attenuate emotional and hormonal responses to stress in borderline personality disorder (BPD)...
  81. ncbi Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans
    Isabel Beets
    Department of Biology, Functional Genomics and Proteomics Unit, KU Leuven, 3000 Leuven, Belgium
    Science 338:543-5. 2012
    Vasopressin- and oxytocin-related neuropeptides are key regulators of animal physiology, including water balance and reproduction...
  82. ncbi Preconditioning of stem cells by oxytocin to improve their therapeutic potential
    Nicolas Noiseux
    Centre de Recherche, Department of Medicine, Universite de Montreal, Quebec, Canada
    Endocrinology 153:5361-72. 2012
    ..We investigated the mechanism of preconditioning of mesenchymal stem cells (MSCs) with oxytocin (OT), which has been proposed as a novel strategy for enhancing therapeutic potential of these cells in ischemic ..
  83. pmc Oxytocin increases heart rate variability in humans at rest: implications for social approach-related motivation and capacity for social engagement
    Andrew H Kemp
    School of Psychology, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 7:e44014. 2012
    b>Oxytocin (OT) plays a key regulatory role in human social behaviour...
  84. ncbi A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder
    Adam J Guastella
    School of Psychology, University of New South Wales, Sydney, Australia
    Psychoneuroendocrinology 34:917-23. 2009
    In humans, oxytocin nasal administration reduces social-threat perception and improves processes involved in communication and the encoding of positive social cues...
  85. ncbi Plasma oxytocin levels and anxiety in patients with major depression
    G Scantamburlo
    Department of Psychiatry, University of Liege, Psychoneuroendocrinology Unit, CHU of Liege, B35, B 4000 Liege, Belgium
    Psychoneuroendocrinology 32:407-10. 2007
    Cerebrospinal fluid and plasmatic levels of oxytocin (OT) have been found to change in mood disorders. In post-mortem studies, the numbers of OT-expressing neurons in the paraventricular nucleus have been reported to be increased...
  86. ncbi Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding
    Ruth Feldman
    Department of Psychology and the Gonda Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    Psychol Sci 18:965-70. 2007
    Although research on the neurobiological foundation of social affiliation has implicated the neuropeptide oxytocin in processes of maternal bonding in mammals, there is little evidence to support such links in humans...
  87. ncbi Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system
    Robert Kumsta
    Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, D 79104 Freiburg, Germany
    Curr Opin Neurobiol 23:11-6. 2013
    The neuropeptide oxytocin has had key roles throughout mammalian evolution in the regulation of complex social cognition and behaviors, such as attachment, parental care, pair-bonding, as well as social exploration and recognition...
  88. pmc Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes
    Marta Busnelli
    Consiglio Nazionale delle Ricerche Institute of Neuroscience, Via Vanvitelli 32, Milan 20143, Italy
    J Biol Chem 287:3617-29. 2012
    ..a bioluminescence resonance energy transfer biosensor to screen for functional selective ligands of the human oxytocin (OT) receptor...
  89. pmc An obligate role of oxytocin neurons in diet induced energy expenditure
    Zhaofei Wu
    Brown Foundation Institute of Molecular Medicine, University of Texas Medical School at Houston, Houston, Texas, USA
    PLoS ONE 7:e45167. 2012
    b>Oxytocin neurons represent one of the major subsets of neurons in the paraventricular hypothalamus (PVH), a critical brain region for energy homeostasis...
  90. ncbi The acute effects of intranasal oxytocin administration on endocrine and sexual function in males
    Andrea Burri
    Department of Psychology, Clinical Psychology and Psychobiology, University of Zurich, Binzmuhlestrasse 14, 8050 Zurich, Switzerland
    Psychoneuroendocrinology 33:591-600. 2008
    The role of the neuropeptide oxytocin (OT) ranges from the modulation of neuroendocrine physiological effects to the establishment of complex social and bonding behaviours...
  91. ncbi Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment
    Saliha Ozsoy
    Erciyes University School of Medicine, Department of Psychiatry, Kayseri, Turkey
    Psychiatry Res 169:249-52. 2009
    ..This study aimed to investigate serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment on these levels...
  92. ncbi The herding hormone: oxytocin stimulates in-group conformity
    Mirre Stallen
    Rotterdam School of Management, Erasmus University Rotterdam
    Psychol Sci 23:1288-92. 2012
    ..Here, we examined whether conformity toward one's in-group is altered by oxytocin, a neuropeptide often implicated in social behavior...
  93. ncbi Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery
    Roman Tyzio
    Institut de Neurobiologie de la Mediterranee, INSERM U29, Universite de la Mediterranee, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France
    Science 314:1788-92. 2006
    ..These events were triggered by oxytocin, an essential maternal hormone for labor...
  94. ncbi Roles of oxytocin neurones in the control of stress, energy metabolism, and social behaviour
    T Onaka
    Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Shinotsuke shi, Tochigi ken, Japan
    J Neuroendocrinol 24:587-98. 2012
    b>Oxytocin neurones are activated by stressful stimuli, food intake and social attachment...
  95. ncbi Soothing music can increase oxytocin levels during bed rest after open-heart surgery: a randomised control trial
    Ulrica Nilsson
    Department of Cardiothoracic Surgery and Centre for Health Care Sciences, Orebro University Hospital and School of Health, Orebro University, P O Box 1324, Orebro SE 70113, Sweden
    J Clin Nurs 18:2153-61. 2009
    ..To evaluate the effect of bed rest with music on relaxation for patients who have undergone heart surgery on postoperative day one...
  96. ncbi Acute cocaine alters oxytocin levels in the medial preoptic area and amygdala in lactating rat dams: implications for cocaine-induced changes in maternal behavior and maternal aggression
    J C Elliott
    Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
    Neuropeptides 35:127-34. 2001
    ..A growing body of evidence suggests that cocaine may alter oxytocin levels leading to impairments in maternal behavior and aggression...
  97. ncbi A neurobiological basis of social attachment
    T R Insel
    Yerkes Primate Center, Emory University, Atlanta, GA 30322, USA
    Am J Psychiatry 154:726-35. 1997
    ..The primary purpose of this article is to describe a novel approach to the neurobiology of attachment...
  98. pmc Social vocalizations can release oxytocin in humans
    Leslie J Seltzer
    Departmentsof Psychology, University of Wisconsin Madison, Madison, WI 53705, USA
    Proc Biol Sci 277:2661-6. 2010
    ..The neurohormone oxytocin (OT) partly governs a number of biological and social processes critical to fitness, such as attachment between ..
  99. ncbi Oxytocin increases gaze to the eye region of human faces
    Adam J Guastella
    School of Psychology, University of New South Wales, Kensington, Sydney, Australia
    Biol Psychiatry 63:3-5. 2008
    In nonhuman mammals, oxytocin has a critical role in peer recognition and social approach behavior. In humans, oxytocin has been found to enhance trust and the ability to interpret the emotions of others...
  100. pmc Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat
    Dara K Shahrokh
    Sackler Program for Epigenetics and Psychobiology at McGill University, Douglas Mental Health University Institute, McGill University, Montreal, Canada
    Endocrinology 151:2276-86. 2010
    Variations in maternal behavior among lactating rats associate with differences in estrogen-oxytocin interactions in the medial preoptic area (mPOA) and in dopamine levels in the nucleus accumbens (nAcc)...
  101. ncbi Oxytocin increases retention of social cognition in autism
    Eric Hollander
    Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 61:498-503. 2007
    b>Oxytocin dysfunction might contribute to the development of social deficits in autism, a core symptom domain and potential target for intervention...

Research Grants76

  1. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..Conversely, depression is linked to decreased function of the central oxytocin (OT) system, which has been also shown to attenuate stress response...
  2. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..Other PVN neuropeptides, such as vasopressin (AVP) and oxytocin (OT), modulate activity of CRH neurons at the level of the PVN as well as enhancing CRH secretogogue activity at ..
  3. Neuropeptide regulation of neurohypophyseal function
    Francis W Flynn; Fiscal Year: 2012
    ..Bodily osmolarity is maintained in a narrow physiological range through the release of vasopressin (VP) and oxytocin (OT) into the blood where the hormones act to promote water retention and sodium excretion...
  4. Epithelial Sodium Channels in the Supraoptic Vasopressin and Oxytocin Neurons
    Ryoichi Teruyama; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The neurohypophysial hormones vasopressin (VP) and oxytocin (OT) are synthesized in the magnocellular neurons (MNCs) located within the paraventricular nucleus (PVN) and the supraoptic nucleus (SON) ..
  5. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ..by examining receptor/hormone expression) shown to be altered in Aim 2);and 4) uterine sensitivity to oxytocin- induced contractions, and cervical dilatability using an ex vivo organ bath system established from mice ..
  6. Transcranial Magnetic Stimulation in Pregnant Women with Depressive Disorder
    Deborah Kim; Fiscal Year: 2013
    ..derived neurotrophic factor (BDNF) and correlate it with levels of estradiol, progesterone, allopregnanolone, oxytocin and corticotrophin-releasing hormone (CRH) levels pre and post-rTMS...
  7. Epithelial Sodium Channels in Vasopressin and Oxytocin Synthesizing Magnocellular
    Ryoichi Teruyama; Fiscal Year: 2013
    ..and proteins for all three ENaC subunits were demonstrated in the rat brain including in vasopressin (VP) and oxytocin (OT) synthesizing magnocellular cells (MNCs) in the hypothalamic supraoptic (SON) and paraventricular (PVN) ..
  8. Sex Differences in the Roles of Oxytocin and Vasopressin in Social Withdrawal
    Michael Q Steinman; Fiscal Year: 2013
    ..Female but not male California mice exposed to social stress spend less time engaging in social interactions. Oxytocin (OT) and arginine vasopressin (AVP) are related neuroproteins that play important roles in social interactions...
  9. DEPOLARIZATION-SECRETION COUPLING IN NERVE TERMINALS
    Jose R Lemos; Fiscal Year: 2012
    ..Vasopressin (AVP) and oxytocin (OT) are synthesized by magnocellular neurons of the hypothalamus and secreted from neurohypophysial (NH) ..
  10. Young Development of a Novel PET Ligand for Detecting Oxytocin Receptors in Brain
    Larry J Young; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Oxytocin (OT) is a neuropeptide that has been implicated in the regulation of social cognition and social behavior both in animal models and in humans...
  11. Genes Influencing Social Behaviors
    DONALD WELLS PFAFF; Fiscal Year: 2010
    A classical view claims that oxytocin (OT) fosters affiliative behaviors and arginine vasopressin (VP) enhances aggression. But a lot of data conflict with this...
  12. ELECTROPHYSIOLOGICAL CORRELATES OF VASOPRESSIN RELEASE
    William E Armstrong; Fiscal Year: 2011
    ..system of the hypothalamus, where neurons in the supraoptic and paraventricular nuclei synthesizing VP and oxytocin (OT) send axons to the posterior pituitary gland to terminate in the neurohemal contact zone...
  13. Climate Change and Health: Assessing the Risk of Preterm Delivery
    Rupa Basu; Fiscal Year: 2013
    ..which could result in decreased uterine blood flow and increased pituitary secretion of anti-diuretic hormone and oxytocin to induce labor...
  14. STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
    YVETTE FRANCE TACHE; Fiscal Year: 2013
    ..delineate the role of key components of the stress response, the brain corticotropin releasing factor (CRF) and oxytocin signaling pathways...
  15. NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIOR
    Harvey J Grill; Fiscal Year: 2013
    ..and neurophysiological experiments targeting LepRbEYFP neurons to determine whether descending hypothalamic oxytocin (OT) and orexin (ORX) projections to mNTS influence food intake by amplifying (ORX) or attenuating (OT) the mNTS ..
  16. Mechanisms of Stress-Enhanced Aversive Conditioning
    Jelena Radulovic; Fiscal Year: 2013
    ..The glutamatergic and oxytocinergic systems, acting via metabotropic glutamate receptors 5 (mGluR5) and oxytocin receptors (Oxtr), respectively, are potently activated during social interactions and co-regulate social behavior...
  17. Fetal Brain Damage: A Placental Disorder
    ANNA PENN; Fiscal Year: 2009
    ..Both established hormones, such as progestins and oxytocin, and hormones that we have recently identified as neuromodulators made by the placenta, such as secretin, will be ..
  18. Molecular Biology of Marfan Syndrome
    Harry C Dietz; Fiscal Year: 2013
    ..The temporal association between release of oxytocin to mediate delivery and lactation (via activation of ERK) and the timing of predisposition has implicated ..
  19. Oxytocin Receptors and Social Behavior
    Larry J Young; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Oxytocin (OT) is a neuropeptide that plays an important role in regulating many aspects of social behavior, including maternal nurturing, social information processing, and social attachment...
  20. Neuropeptide Modulation of Taste Signals
    Nirupa Chaudhari; Fiscal Year: 2010
    ..b>Oxytocin is a potent anorexigenic peptide that plays a key role at hypothalamic and hindbrain centers that regulate ..
  21. Identifying Genetic Risk for Maternal Insensitivity and Infant Dysregulation
    Esther M Leerkes; Fiscal Year: 2013
    ..D2 and D4, dopamine transporter DAT-1, catechol-O- methyltransferase -COMT, serotonin transporter- 5-HTTPR, and oxytocin receptor-OXTR)...
  22. Maternal Brain and Behavioral Responses to Infant Cues in Cocaine Exposed Mothers
    Lane Strathearn; Fiscal Year: 2013
    ..Maternal behavior is strongly influenced my oxytocin, an important neuromodulator and hormone, which may also be modulated by maternal cocaine abuse...
  23. Early experience and emotional development in free-ranging primates
    Karen J Parker; Fiscal Year: 2013
    ..suppression test, metyrapone test, ACTH challenge);and c) assessment of stress-induced CSF concentrations of CRF, oxytocin, and monoamine metabolites...
  24. Neuroendocrine-modulated epithelial HCO3- transport
    Bruce D Schultz; Fiscal Year: 2013
    ..Norepinephrine and adenosine stimulate PKA whereas oxytocin stimulates PKC to achieve anion secretion...
  25. Social attachment and reproductive regulation
    HEATHER ELIZABETH WATTS; Fiscal Year: 2010
    ..Vasopressin and oxytocin are important in pair-bond formation induced by mating, but less is known about their role in the formation of ..
  26. Assessing the Influence of Oxytocin on Postpartum Depression Using Brain Imaging
    Julia R Heiman; Fiscal Year: 2010
    ..The neuropeptide oxytocin is known to decrease neural activation in the limbic system (Kirsch et al...
  27. Design & Synthesis of Novel CNS-Active Oxytocin and Vasopressin Receptor Ligands
    Edward Roberts; Fiscal Year: 2010
    The cyclic nonapeptides hormones vasopressin and oxytocin regulate many important mammalian functions...
  28. Administrative Supplement: MBSR and Anxiety: Therapeutic and Neuroendocrine Effec
    Elizabeth A Hoge; Fiscal Year: 2013
    ..threat, and that this decrease will be associated with increases in the pro-approach pro-trust neuropeptide oxytocin. Oxytocin increases trust in humans and increases approach behavior to novel stimuli and reduces anxiety in a ..
  29. Oxytocin and Oxytocin Neurons in the Hypothalamic Regulation of Feeding
    Bassil M Kublaoui; Fiscal Year: 2012
    ..We found that Sim1 mice have a profound deficiency in Oxytocin (Oxt) in the paraventricular nucleius (PVN) and Supraoptic Nucleus (SON)...
  30. Stress Responses, Psychosocial Stress and Pain Perception in African Americans
    Susan S Girdler; Fiscal Year: 2010
    ..responses of the hypothalamic-pituitary-adrenal (HPA) and sympathetic nervous system axes (SNS), and also lower oxytocin (OT) and allopregnanolone (AP), and the absence of relationship to pain sensitivity during activation of these ..
  31. Optical Study of Secretion in Mammalian Nerve Terminals
    BRIAN MATTHEW SALZBERG; Fiscal Year: 2013
    ..and terminate in the neurohypophysis, a quasi-pure collection of nerve terminals, where the neuropeptides oxytocin and vasopressin are released into the circulation...
  32. Receptor Selective Spinal Analgesia
    James Eisenach; Fiscal Year: 2013
    ..it is performed at the time of delivery, and preliminary studies suggest this is due to release of the hormone, oxytocin, into the spinal cord by nerves which descend from the hypothalamus...
  33. Role of Sim1 in Hyperphagic Obesity
    Bassil M Kublaoui; Fiscal Year: 2010
    ..We will use Sim1 GFP mice to examine colocalization of Sim1, MTII induced c-fos, and oxytocin. We will use various molecules to attempt to rescue the Sim1 obesity phenotype...
  34. Long-term benefits of dog ownership: Effects on stress and social behavior
    Kristen Jacobson; Fiscal Year: 2013
    ..However, a number of research questions remain unanswered. First, do biological mechanisms (e.g., oxytocin) associated with HAI in previous studies mediate relationships between HAI and prosocial behavior and stress? ..
  35. Sim1 Function in Feeding Regulation
    Andrew R Zinn; Fiscal Year: 2013
    ..final aim tests whether Sim1 regulates feeding behavior by acting in specific subsets of PVN neurons expressing oxytocin, Trh, or Crh...
  36. The role of vasopressin in the social deficits of autism
    Karen J Parker; Fiscal Year: 2013
    ..A large body of research has shown that the closely related neuropeptides arginine-vasopressin (AVP) and oxytocin (OT) play critical roles in adaptive social functioning...
  37. Role of the PVN in Chronic Intermittent Hypoxia-Induced Cardiorespiratory Changes
    Prabha Kc; Fiscal Year: 2012
    ..However, hypothalamic paraventricular (PVN) neurons containing vasopressin and/or oxytocin, also receive inputs from the NTS...
  38. Training in translational social neuroscience
    Lisa A Parr; Fiscal Year: 2013
    ..This will include training in how to determine drug doses and delivery methods for administering oxytocin to primates...
  39. Mood, mother and infant: The psychobiology of impaired dyadic development
    Alison M Stuebe; Fiscal Year: 2013
    ..Recent work implicates reductions in oxytocin, a neuropeptide that plays a central role in mothering and social behavior, in the pathophysiology of this ..
  40. Caspase-3 Maintains Uterine Quiescence in a PR and NF-Kappa B Dependent Manner
    Jennifer C Condon; Fiscal Year: 2013
    ..The priming of the pregnant uterus for contraction is associated with increased oxytocin receptors, increased gap junctions and cervical ripening...
  41. Oxytocin regulation of social buffering following stress
    ADAM STEVEN SMITH; Fiscal Year: 2012
    ..of social support following a stressful experience, particularly the mediating effects of the neuropeptide oxytocin (OT)...
  42. Molecular Mechanism of Allosteric Modulation of the Oxytocin Receptor by Sterols
    VADIM GENNADYEVICH CHEREZOV; Fiscal Year: 2013
    ..provided by applicant): This proposal is focused on the X-ray structure determination of a complex between the oxytocin receptor (OXTR), a member of the G Protein-Coupled Receptor (GPCR) family, and cholesterol, a ubiquitous lipid in ..
  43. Sim1 Neurons and Body Weight Regulation
    Qingchun Tong; Fiscal Year: 2013
    ..g. corticotrophin-releasing hormone, thyrotrophin-releasing hormone and oxytocin)...
  44. Oxytocin Modulation of CRF Neurons in the BNST: Implications for Anxiety
    SARAH ELIZABETH DEWITT; Fiscal Year: 2013
    ..stria terminalis (BNST) is a region of the extended amygdala in which multiple neuropeptide systems, including oxytocin and corticotropin releasing factor (CRF), have the potential to interact and regulate anxiety-like behaviors...
  45. Central amygdala input circuits control stress-induced anxiety after chronic ETOH
    Garret D Stuber; Fiscal Year: 2013
    ..CRF, other inputs that synapse on CeA neurons are glutamate (GLU) terminals from the basolateral amygdala (BLA), oxytocin (OXY) terminals from the hypothalamus, and vasopressin (VP ) terminals...
  46. Sex-specific regulation of social behavior: Focus on oxytocin and neural circuits
    Kelly M Dumais; Fiscal Year: 2013
    ..I will focus on the role of the oxytocin (OT) system in the brain as OT is an evolutionarily highly conserved neuropeptide, plays a key role in the ..
  47. Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor
    Chad A Grotegut; Fiscal Year: 2013
    ..With increasing labor induction rates comes the likelihood of increased numbers of women receiving prolonged oxytocin infusions...
  48. Role of Oxytocin Signaling in the Pathogenesis of Diet-Induced Obesity
    JAMES ERNEST BLEVINS; Fiscal Year: 2013
    ..A circuit of oxytocin neurons in the hypothalamic parvocellular paraventricular nucleus (pPVN) that project to the nucleus of the ..
  49. Prenatal Cocaine, Smoking And Oxytocin In Humans
    Karen M Grewen; Fiscal Year: 2010
    ..This new line of inquiry is based on animal studies that identify the neuropeptide, oxytocin (OT) as essential for establishment of normal maternal behaviors in mammals, and that describe the disruptions in ..
  50. Oxytocin's novel antianxiety effect
    Jeffrey B Rosen; Fiscal Year: 2012
    ..background anxiety, for common symptoms of anxiety, depression, schizophrenia and autism disorders, and 2) oxytocin, a hormone which selectively diminishes background anxiety...
  51. Motherhood, Oxytocin and the Medial Prefrontal Cortex
    BENEDETTA J LEUNER; Fiscal Year: 2013
    ..The neuropeptide oxytocin has been shown to buffer stress hormone effects on the brain and behavior and may play a role in protecting mPFC ..
  52. Neuroendocrine Control of Paternal Care in the Common Marmoset
    Toni Elaine Ziegler; Fiscal Year: 2010
    ..We will examine changes in prolactin, oxytocin, vasopressin and dopamine with steroid stimulation in both central and peripheral samples...
  53. Serotonin Reuptake Inhibitors and 5-HT1A Receptors
    George Battaglia; Fiscal Year: 2009
    ..serotonin-selective reuptake inhibitors (SSRIs) desensitize 5-HT1A activation of plasma hormones such as ACTH and oxytocin. The long-term objective of this proposal is to develop better treatment strategies by understanding the ..
  54. Exploring sex differences in the neural correlates of PTSD: Impact of oxytocin
    MARGARET M MORAN-SANTA MARIA; Fiscal Year: 2013
    ..b>Oxytocin (OT) is a neuropeptide that promotes social bonding, trust and calmness...
  55. Psychological stress, associate biologic mediators, and ovarian cancer risk
    Shelley S Tworoger; Fiscal Year: 2013
    ..Further, a number of biologic mediators of the stress response have been identified, including MMP-2, prolactin, oxytocin, and telomere length...
  56. Affective and Genomic Mediators of Sustained Behavior Change
    BARBARA LEE FREDRICKSON; Fiscal Year: 2013
    ..e., oxytocin, respiratory sinus arrhythmia, blood pressure, and C-reactive protein) and inflammation-related genetic ..
  57. Neurodevelopmental Mechanisms of Social Behavior
    PAT R LEVITT; Fiscal Year: 2011
    ..In Aims 1 and 2, experiments will investigate the interactions of the oxytocin (OXT) and arginine-vasopressin (AVP) neuropeptide systems with ?-aminobutyric acid-synthesizing (GABA) ..
  58. Reproductive Plasticity in Oxytocin Neurons
    William E Armstrong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Oxytocin (OT) functions as a hormone in labor and lactation and as a neuromodulator in the brain. OT receptors are present on OT neurons, which they autoregulate during somatodendritic OT release...
  59. Autism: neuropeptide hormones and potential pathway genes
    Suma Jacob; Fiscal Year: 2012
    ..clinical phenotype, neurochemical measures and genetic associations of related neuropeptide hormones, including oxytocin (OT) which is currently under trial for ASD treatment...
  60. Is Ecstasy an Empathogen? Effects of MDMA on Social and Emotional Processing
    Harriet de Wit; Fiscal Year: 2010
    ..a history of ecstasy use will be tested with MDMA and two active control drugs, methamphetamine (MA;20mg) and oxytocin (OT, 20 IU)...
  61. Cardiovascular disease, depression, and oxytocin
    MELISSA SCOTTI; Fiscal Year: 2013
    ..However, the mechanisms underlying this relationship are not well understood. Oxytocin (OT) is thought to be involved in this association as it plays a role in both emotion/mood and cardiovascular ..
  62. The protective effect of oxytocin on social isolation: physiological mechanisms
    JASON RICHARD YEE; Fiscal Year: 2011
    ..The hypothesis to be examined suggests that oxytocin (OT) plays a central role in buffering against emotional and autonomic reactivity, including stress and anxiety ..
  63. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
    ..In the magnocellular neuroendocrine system, IL-1beta is contained in secretory granules separate from oxytocin (OT) and vasopressin (VP) indicative of independent release...
  64. Neuropeptide Regulation Vasopressin/Oxytocin Secretion
    CELIA SLADEK; Fiscal Year: 2006
    Vasopressin (VP) and oxytocin (OT) secretion from the posterior pituitary occurs as a result of a variety of neurotransmitters and neuropeptide afferents to the supraoptic and paraventricular nuclei in the hypothalamus...
  65. COCAINE & MATERNAL AGGRESSION--OXYTOCINERGIC MECHANISMS
    JOSEPHINE JOHNS; Fiscal Year: 2005
    ..has been shown to increase aggression towards an intruder (maternal aggression) and reduce the levels of oxytocin (OXY) in the amygdala of rats on postpartum days (PPD) 6-10...
  66. COCAINE AND MATERNAL NEGLECT: INTERGENERATIONAL EFFECTS
    JOSEPHINE JOHNS; Fiscal Year: 2003
    ..Recently, lower levels of oxytocin and cocaine use during pregnancy have also been associated with general feelings of anger and hostility and ..
  67. RENAL FUNCTION AND BLOOD PRESSURE CONTROL IN PREGNANCY
    Edmond Quillen; Fiscal Year: 2000
    ..We hypothesize that estrogen is involved in the enhancement of ANF secretion and that oxytocin may be a necessary intermediate factor in this response...
  68. CYTOKINE REGULATION OF UTERINE OXYTOCIN RECEPTOR
    PHILLIP RAUK; Fiscal Year: 2001
    ..b>Oxytocin, however, clearly plays a role in the maintenance if not initiation of both term and preterm labor...
  69. OXYTOCIN REGULATION BY NEUROSTEROIDS & GABA-A RECEPTOR
    Janet Amico; Fiscal Year: 2003
    b>Oxytocin(OT) is a nonapeptide that functions as both a hormone and a neuropeptide during certain reproductive processes and behaviors...
  70. Spike After-Potentials of Oxytocin Cells in Lactation
    Ryoichi Teruyama; Fiscal Year: 2005
    ..The oxytocin (OT) neuron in the supraoptic nucleus (SON) of the hypothalamus is one of the best models to study such ..
  71. Oxytocin enhances afferent synaptic transmission within the NTS.
    JAMES PETERS; Fiscal Year: 2009
    ..Two prototypic neuropeptides, arginine vasopressin (AVP) and oxytocin (OT), are synthesized in the PVN and contained in axons terminating within NTS...
  72. REPRODUCTIVE EFFECTS OF OXYTOCIN DEFICIENCY
    CHRISTINA LUEDKE; Fiscal Year: 2001
    DESCRIPTION (Taken from the applicant's Abstract) Oxytocin is a peptide hormone, produced in the hypothalamus and in various reproductive organs, that is proposed to be a major regulator of reproductive physiology and behavior...
  73. SYSTEMIC AND LOCAL REGULATION OF MYOMETRIAL ACTIVITY
    Jorge Figueroa; Fiscal Year: 1993
    This proposal addresses the interactions between the sympathoadrenal system (SAS), prostaglandins (PG) and oxytocin (OT) in regulating myometrial activity in sheep...
  74. CENTRAL OXYTOCIN STIMULATION OF LHRH AND LH RELEASE
    Craig Johnston; Fiscal Year: 1991
    ..of this research project is to characterize the nature, manner, mechanisms and site(s) of action by which central oxytocin (OXY) neurons regulate the release of luteinizing hormone releasing hormone (LHRH) and luteinizing hormone (LH) ..
  75. BRAIN OXYTOCIN RECEPTORS--FUNCTION AND STRUCTURE
    LORETTA FLANAGAN CATO; Fiscal Year: 2001
    ..Previous studies have shown that oxytocin receptors (OTRs) in the hypothalamus facilitate female sexual behavior after pretreatment with estradiol and ..
  76. TRANSCRIPTIONAL CONTROL IN NEUROHYPOPHYSIAL NEURONS
    JOSEPH MCCABE; Fiscal Year: 2001
    ..This project will focus upon the regulation of four neuropeptides: vasopressin oxytocin, cholecystokinin, and galanin, in the hypothalamo- neurohypophysial system (NHS) of the CNS...