thyrotropin

Summary

Summary: A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.

Top Publications

  1. ncbi Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone
    E Dale Abel
    Division of Endocrinology, University of Utah School of Medicine, 15 North 2030 East, Building 533, Room 3410B, Salt Lake City, Utah 84112, USA
    Mol Endocrinol 17:1767-76. 2003
  2. ncbi Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)
    Joseph G Hollowell
    Centers for Disease Control, National Center for Environmental Health, Division of Emergency and Environmental Services, Atlanta, Georgia 30341, USA
    J Clin Endocrinol Metab 87:489-99. 2002
  3. pmc Extreme longevity is associated with increased serum thyrotropin
    Gil Atzmon
    Department of MedicineDivision of Endocrinology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Endocrinol Metab 94:1251-4. 2009
  4. ncbi Subclinical thyroid disease: scientific review and guidelines for diagnosis and management
    Martin I Surks
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
    JAMA 291:228-38. 2004
  5. ncbi The clinical significance of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Endocr Rev 29:76-131. 2008
  6. ncbi Prospective evaluation of the natural course of idiopathic subclinical hypothyroidism in childhood and adolescence
    Malgorzata Wasniewska
    Department of Pediatrics, University of Messina, Messina, Italy
    Eur J Endocrinol 160:417-21. 2009
  7. pmc Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 41:460-4. 2009
  8. pmc Involvement of thyrotropin in photoperiodic signal transduction in mice
    Hiroko Ono
    Laboratory of Animal Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 105:18238-42. 2008
  9. ncbi Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism
    Martin I Surks
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York 10467, USA
    J Clin Endocrinol Metab 92:4575-82. 2007
  10. ncbi A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study
    J Parle
    School of Health and Population Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B152TT, United Kingdom
    J Clin Endocrinol Metab 95:3623-32. 2010

Research Grants

  1. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
  2. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
  3. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2009
  4. Developmental defects in serotonin neurons and the response to O2 and CO2
    George B Richerson; Fiscal Year: 2011
  5. Immunoglobulin Activation of Fibroblasts
    Terry J Smith; Fiscal Year: 2012
  6. Role of Oleylethanolamine in the Regulation of the HPT Axis
    Csaba Fekete; Fiscal Year: 2010
  7. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
  8. Neuroendocrine Control of Glucose Metabolism
    Gregory J Morton; Fiscal Year: 2013
  9. GENETIC SUSCEPTIBILITY TO GRAVES'-LIKE HYPERTHYROIDISM IN MICE
    Sandra M McLachlan; Fiscal Year: 2013
  10. TSH RECEPTOR MULTIMERIZATION
    TERRY FRANCIS DAVIES; Fiscal Year: 2013

Detail Information

Publications389 found, 100 shown here

  1. ncbi Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone
    E Dale Abel
    Division of Endocrinology, University of Utah School of Medicine, 15 North 2030 East, Building 533, Room 3410B, Salt Lake City, Utah 84112, USA
    Mol Endocrinol 17:1767-76. 2003
    ....
  2. ncbi Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)
    Joseph G Hollowell
    Centers for Disease Control, National Center for Environmental Health, Division of Emergency and Environmental Services, Atlanta, Georgia 30341, USA
    J Clin Endocrinol Metab 87:489-99. 2002
    ..A large proportion of the U.S. population unknowingly have laboratory evidence of thyroid disease, which supports the usefulness of screening for early detection...
  3. pmc Extreme longevity is associated with increased serum thyrotropin
    Gil Atzmon
    Department of MedicineDivision of Endocrinology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Endocrinol Metab 94:1251-4. 2009
    ..The distribution of serum TSH shifts progressively to higher concentrations with age...
  4. ncbi Subclinical thyroid disease: scientific review and guidelines for diagnosis and management
    Martin I Surks
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
    JAMA 291:228-38. 2004
    ..The necessity for further evaluation, possible treatment, and the urgency of treatment have not been clearly established...
  5. ncbi The clinical significance of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Endocr Rev 29:76-131. 2008
    ..the potential risk of progression to overt disease, and there is no consensus on the thyroid hormone and thyrotropin cutoff values at which treatment should be contemplated...
  6. ncbi Prospective evaluation of the natural course of idiopathic subclinical hypothyroidism in childhood and adolescence
    Malgorzata Wasniewska
    Department of Pediatrics, University of Messina, Messina, Italy
    Eur J Endocrinol 160:417-21. 2009
    ..To prospectively evaluate the course of subclinical hypothyroidism (SH) in children and adolescents with no underlying diseases and no risk factors, which might interfere with the progression of SH...
  7. pmc Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 41:460-4. 2009
    ..33 allele is associated with low concentration of thyroxin (T(4)) and high concentration of triiodothyronine (T(3))...
  8. pmc Involvement of thyrotropin in photoperiodic signal transduction in mice
    Hiroko Ono
    Laboratory of Animal Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 105:18238-42. 2008
    ..Taken together, our findings suggest that melatonin-dependent regulation of thyroid hormone levels in the MBH appears to involve TSH in mammals...
  9. ncbi Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism
    Martin I Surks
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York 10467, USA
    J Clin Endocrinol Metab 92:4575-82. 2007
    ..5 mIU/liter, increased progressively with age. Age-adjusted reference ranges would include many people with TSH greater than 4.5 mIU/liter...
  10. ncbi A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study
    J Parle
    School of Health and Population Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B152TT, United Kingdom
    J Clin Endocrinol Metab 95:3623-32. 2010
    ..Subclinical hypothyroidism (SCH) and cognitive dysfunction are both common in the elderly and have been linked. It is important to determine whether T4 replacement therapy in SCH confers cognitive benefit...
  11. ncbi TSH is a negative regulator of skeletal remodeling
    Etsuko Abe
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 115:151-62. 2003
    ..These studies define a role for TSH as a single molecular switch in the independent control of both bone formation and resorption...
  12. ncbi Obesity and thyroid function
    Thomas Reinehr
    Department of Paediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Mol Cell Endocrinol 316:165-71. 2010
    A moderate elevation of thyrotropin (TSH) concentrations, which is associated with triiodothyronine (T3) values in or slightly above the upper normal range, is frequently found in obese humans...
  13. pmc Subclinical hypothyroidism and the risk of coronary heart disease and mortality
    Nicolas Rodondi
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Bugnon 44, 1011 Lausanne, Switzerland
    JAMA 304:1365-74. 2010
    ..This might reflect differences in participants' age, sex, thyroid-stimulating hormone (TSH) levels, or preexisting cardiovascular disease...
  14. pmc Thyroid status, cardiovascular risk, and mortality in older adults
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    JAMA 295:1033-41. 2006
    ..Previous studies have suggested that subclinical abnormalities in thyroid-stimulating hormone levels are associated with detrimental effects on the cardiovascular system...
  15. ncbi Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation
    Sandra Mueller
    III Medical Department, University of Leipzig, Leipzig, Germany
    J Biol Chem 283:18048-55. 2008
    ..We demonstrate that the hinge region represents an extracellular intermediate connector for both hormone binding and signal transduction of the hTSHR...
  16. ncbi Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss
    M Nannipieri
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Int J Obes (Lond) 33:1001-6. 2009
    ....
  17. pmc Defining structural and functional dimensions of the extracellular thyrotropin receptor region
    Gunnar Kleinau
    Department for Structural Biology, Leibniz Institut fur Molekulare Pharmakologie, D 13125 Berlin, Germany
    J Biol Chem 286:22622-31. 2011
    The extracellular region of the thyrotropin receptor (TSHR) can be subdivided into the leucine-rich repeat domain (LRRD) and the hinge region. Both the LRRD and the hinge region interact with thyrotropin (TSH) or autoantibodies...
  18. ncbi Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration
    K Boelaert
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
    J Clin Endocrinol Metab 91:4295-301. 2006
    ..Thyroid nodules and goiter are common, and fine-needle aspiration biopsy (FNAB) is the first investigation of choice in distinguishing benign from malignant disease...
  19. pmc Thyrotropin levels in a population with no clinical, autoantibody, or ultrasonographic evidence of thyroid disease: implications for the diagnosis of subclinical hypothyroidism
    Thomas E Hamilton
    Program in Epidermology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Clin Endocrinol Metab 93:1224-30. 2008
    ..The current debate regarding whether to decrease the upper limit for the TSH reference range to 2.5 microIU/ml has considerable potential impact on the diagnosis and treatment of subclinical hypothyroidism worldwide...
  20. pmc Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function
    Lisette Arnaud-Lopez
    Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA
    Am J Hum Genet 82:1270-80. 2008
    ..This would affect production of T4 and T3 and feedback to alter TSH release by the pituitary. PDE8B may thus provide a candidate target for the treatment of thyroid dysfunction...
  21. ncbi Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women
    G De Pergola
    Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Via Putignani 236, 70122 Bari, Italy
    Clin Endocrinol (Oxf) 67:265-9. 2007
    ..To examine whether obesity, body fat distribution and insulin resistance have an independent effect on serum TSH and free thyroid hormones (FT3 and FT4) in a cohort of euthyroid women, represented by overweight and obese patients...
  22. pmc Trimester-specific changes in maternal thyroid hormone, thyrotropin, and thyroglobulin concentrations during gestation: trends and associations across trimesters in iodine sufficiency
    O P Soldin
    Division of Cancer Genetics and Epidemiology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC 20057 1465, USA
    Thyroid 14:1084-90. 2004
    ..To describe the interrelationships of thyroid functions based on trimester-specific concentrations in healthy, iodine-sufficient pregnant women across trimesters, and postpartum...
  23. ncbi Narrow individual variations in serum T(4) and T(3) in normal subjects: a clue to the understanding of subclinical thyroid disease
    Stig Andersen
    Department of Endocrinology, Aalborg Hospital, Aalborg, Denmark DK 9000
    J Clin Endocrinol Metab 87:1068-72. 2002
    ..For the same degree of thyroid function abnormality, the diagnosis depends to a considerable extent on the position of the patient's normal set point for T(4) and T(3) within the laboratory reference range...
  24. ncbi The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects
    S J Bakker
    Department of Internal Medicine, University Hospital Groningen, 9700 RB Groningen
    J Clin Endocrinol Metab 86:1206-11. 2001
    ..Importantly, the effect-modification of the association of TSH with LDL-C by insulin sensitivity suggests that insulin-resistant subjects are most susceptible to this increased risk...
  25. pmc Congenital hypothyroidism
    Maynika V Rastogi
    Department of Pediatrics, Division of Endocrinology, Oregon Health and Science University, 707 SW Gaines Street, Portland, OR, USA
    Orphanet J Rare Dis 5:17. 2010
    ..Studies show that a lower neurocognitive outcome may occur in those infants started at a later age (> 30 days of age), on lower l-thyroxine doses than currently recommended, and in those infants with more severe hypothyroidism...
  26. ncbi A single recombinant human thyrotropin-stimulated serum thyroglobulin measurement predicts differentiated thyroid carcinoma metastases three to five years later
    Richard T Kloos
    Division of Endocrinology, Shands Hospital, 1600 SW Archer Road, P O Box 100226, Gainesville, Florida 32610 0226, USA
    J Clin Endocrinol Metab 90:5047-57. 2005
    ..Testing for residual differentiated thyroid carcinoma relies heavily upon recombinant human (rh)TSH-stimulated serum thyroglobulin (Tg) levels, but the positive predictive value is often low...
  27. ncbi The evidence for a narrower thyrotropin reference range is compelling
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, 110 Irving Street NW, Washington, D C 20010 2975, USA
    J Clin Endocrinol Metab 90:5483-8. 2005
    ..Recognition and establishment of a more precise and true normal range for TSH have important implications for both screening and treatment of thyroid disease in general and subclinical thyroid disease in particular...
  28. ncbi Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones
    Eniko Bodo
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Endocrinology 151:1633-42. 2010
    ..Intraepidermal TSH expression appears to be regulated by the classical endocrine controls that determine the systemic HPT axis...
  29. ncbi Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality
    Nicolas Ochs
    University of Lausanne, Lausanne, Switzerland
    Ann Intern Med 148:832-45. 2008
    ..Data on the association between subclinical thyroid dysfunction and coronary heart disease (CHD) and mortality are conflicting...
  30. ncbi Rapid regulation of thyroid sodium-iodide symporter activity by thyrotrophin and iodine
    Andrea C F Ferreira
    Laboratório de Fisiologia Endócrina, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Endocrinol 184:69-76. 2005
    ..Therefore, our data show that modulation of the thyroid NIS by TSH depends primarily on thyroid iodine content and, further, that the regulation of NIS activity is rapid...
  31. ncbi Children with congenital hypothyroidism: long-term intellectual outcome after early high-dose treatment
    Anastasia Dimitropoulos
    Child Development Center, University Children s Hospital Zurich, Zurich 8032, Switzerland
    Pediatr Res 65:242-8. 2009
    ..Those adolescents with athyreosis and lower SES are at particular risk for adverse outcome. Therefore, early detection of intellectual deficits is mandatory in children with CH...
  32. ncbi Role of ultrasonography in outcome prediction in subclinical hypothyroid patients treated with levothyroxine
    Dong Yeob Shin
    Endocrinology, Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Endocr J 57:15-22. 2010
    ..8% for TPOAb and 50.0% for TgAb) in the outcome prediction of SCH. Thyroid US may provide valuable information on the course of SCH, and DT pattern can serve as a prognostic factor when combined with other known parameters...
  33. pmc Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage
    Megan Rist Haymart
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Clin Endocrinol Metab 93:809-14. 2008
    ..TSH is a known thyroid growth factor, but the pathogenic role of TSH in thyroid oncogenesis is unclear...
  34. ncbi Natural history of mild subclinical hypothyroidism: prognostic value of ultrasound
    Pedro W S Rosário
    Department of Thyroid, Endocrinology Service, Santa Casa de Belo Horizonte, Minas Gerais, Brazil
    Thyroid 19:9-12. 2009
    ..Therefore, we sought to evaluate the natural history of this milder form of SCH (TSH < or =10 mIU/L with normal thyroid hormone levels) in adult women patients...
  35. ncbi Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population
    Nils Knudsen
    Endocrine Unit, Medical Clinic I, Bispebjerg Hospital, Copenhagen, Denmark
    J Clin Endocrinol Metab 90:4019-24. 2005
    ..Few data have been presented regarding an association between variations in thyroid function seen in the general population and body weight...
  36. pmc A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism
    J H Duncan Bassett
    Molecular Endocrinology Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, United Kingdom
    Mol Endocrinol 22:501-12. 2008
    ..Furthermore, TSH did not affect the differentiation or function of osteoblasts or osteoclasts in vitro. These data indicate the hypothalamic-pituitary-thyroid axis regulates skeletal development via the actions of T(3)...
  37. ncbi Thyroid hormone use, hyperthyroidism and mortality in older women
    Douglas C Bauer
    Division of General Internal Medicine, University of California, San Francisco, CA 94107, USA
    Am J Med 120:343-9. 2007
    ..We performed a prospective cohort study to examine the relationship among thyroid hormone use, previous hyperthyroidism, abnormal thyroid function, and mortality...
  38. pmc CD133+ anaplastic thyroid cancer cells initiate tumors in immunodeficient mice and are regulated by thyrotropin
    Susan Friedman
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 4:e5395. 2009
    ..Its rapid onset and resistance to conventional therapeutics contribute to a mean survival of six months after diagnosis and make the identification of thyroid-cancer-initiating cells increasingly important...
  39. ncbi Iodine status and thyroid function of pregnant, lactating women and infants (0-1 yr) residing in areas with an effective Universal Salt Iodization program
    Yanling Wang
    College of Earth and Environment Sciences, Lanzhou University, Lanzhou Gansu, China
    Asia Pac J Clin Nutr 18:34-40. 2009
    ..To assess the iodine nutrition and thyroid function of pregnant women, lactating women and infants residing in areas where the Universal Salt Iodization program is in place...
  40. ncbi Physiological relevance of thyroid stimulating hormone and thyroid stimulating hormone receptor in tissues other than the thyroid
    John R Klein
    Dental Branch, Department of Diagnostic Sciences, The University of Texas Health Science Center at Houston, Room 4 133, 6516 M D Anderson Blvd, Houston, TX 77030, USA
    Autoimmunity 36:417-21. 2003
    ....
  41. ncbi Thyroid physiology
    Nikolaos Stathatos
    Department of Medicine, Thyroid Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Med Clin North Am 96:165-73. 2012
    ..Such discoveries have significantly improved our understanding of thyroid physiology. As a result, new diagnostic and therapeutic approaches for the management of thyroid disorders are now available or in development...
  42. pmc Papillary thyroid carcinoma in an autonomous hyperfunctioning thyroid nodule: case report and review of the literature
    Hala M Tfayli
    Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    Thyroid 20:1029-32. 2010
    ..Discovery of a nodule in the context of hyperthyroidism is usually comforting due to the presumption that the nodule represents a benign toxic adenoma...
  43. pmc Longitudinal study of thyroid function in Down's syndrome in the first two decades
    P A Gibson
    Department of Paediatrics, Royal Lancaster Infirmary, Lancaster, UK
    Arch Dis Child 90:574-8. 2005
    ..4 years). At the second test two were hypothyroid and two with isolated raised thyroid stimulating hormone (IR-TSH) were receiving thyroxine...
  44. ncbi Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma
    Matteo Landriscina
    Dipartimento di Scienze Mediche e del Lavoro, Universita degli Studi di Foggia, Viale Pinto, 1 71100 Foggia, Italy
    J Clin Endocrinol Metab 90:5663-71. 2005
    ..Two nonnucleosidic RT inhibitors, efavirenz and nevirapine, currently used in HIV treatment, reversibly down-regulate tumor growth and induce differentiation in several human tumor cell models...
  45. ncbi Clinical effectiveness and cost-effectiveness of the use of the thyroxine/thyroxine-binding globulin ratio to detect congenital hypothyroidism of thyroidal and central origin in a neonatal screening program
    Caren I Lanting
    Department of Social Pediatrics and Child and Youth Health Care, Netherlands Organization of Applied Scientific Research Prevention and Health, PO Box 2215, 2301 CE Leiden, Netherlands
    Pediatrics 116:168-73. 2005
    ..Since the introduction of screening for congenital hypothyroidism (CH) in 1974, the optimal laboratory strategy has been the subject of debate...
  46. ncbi Serum Basal thyroglobulin measured by a second-generation assay correlates with the recombinant human thyrotropin-stimulated thyroglobulin response in patients treated for differentiated thyroid cancer
    Carole Spencer
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Thyroid 20:587-95. 2010
    Recombinant human thyrotropin (rhTSH) stimulation is frequently used to assess the disease status of patients treated for differentiated thyroid cancer (DTC) when basal (unstimulated) thyroglobulin (b-Tg) is below the assay sensitivity ..
  47. ncbi Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis
    Marco Centanni
    Endocrinology Unit, Department of Experimental Medicine and Pathology, University La Sapienza, Polo Pontino, Latina, Italy
    N Engl J Med 354:1787-95. 2006
    ..We determined whether there is an increased need for thyroxine in patients with euthyroid multinodular goiter and impaired secretion of gastric acid...
  48. ncbi Trends in incidence rates of congenital hypothyroidism related to select demographic factors: data from the United States, California, Massachusetts, New York, and Texas
    Cynthia F Hinton
    Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Pediatrics 125:S37-47. 2010
    ..In Massachusetts (1995-2007), low birth weight newborns or newborns who had a delayed rise in thyrotropin concentration accounted for the majority of the recent rate increase...
  49. pmc A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study
    Vijay Panicker
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia
    Am J Hum Genet 87:430-5. 2010
    ..Circulating concentrations of thyrotropin (TSH), thyroxine (T4) and triiodothyronine (T3) have a strong heritable component and are thought to be under ..
  50. ncbi Neonatal screening for congenital hypothyroidism in West Black Sea area, Turkey
    E Simsek
    Abant Izzet Baysal University, Duzce School of Medicine, Department of Pediatrics, Duzce, Turkey
    Int J Clin Pract 59:336-41. 2005
    ..Neonatal screening for CH was performed using blood specimens collected onto filter paper. Thyrotropin [thyroid-stimulating hormone (TSH)] was measured by radioimmunoassay, and a value >20 microU/ml was ..
  51. ncbi Assessment of the incremental value of recombinant thyrotropin stimulation before 2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography imaging to localize residual differentiated thyroid cancer
    S Leboulleux
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, Villejuif, France
    J Clin Endocrinol Metab 94:1310-6. 2009
    ....
  52. ncbi Thyrotropin serum concentrations in patients with papillary thyroid microcancers
    Marion Gerschpacher
    Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Thyroid 20:389-92. 2010
    Recent studies have shown that elevated serum thyrotropin (thyroid-stimulating hormone [TSH]) concentrations are associated with an increased risk of differentiated thyroid cancers in patients with nodular goiter...
  53. ncbi The Thyroid Epidemiology, Audit, and Research Study (TEARS): morbidity in patients with endogenous subclinical hyperthyroidism
    Thenmalar Vadiveloo
    Dundee Epidemiology and Biostatistics Unit, Division of Clinical and Population Sciences and Education, Mackenzie Building, Kirsty Semple Way, University of Dundee, Dundee, Scotland, DD2 4BF United Kingdom
    J Clin Endocrinol Metab 96:1344-51. 2011
    ..Our objective was to investigate the long-term outcomes for patients with endogenous subclinical hyperthyroidism (SH)...
  54. ncbi Presence of thyrotropin receptor in hepatocytes: not a case of illegitimate transcription
    Wei Zhang
    Department of Endocrinology, Provincial Hospital affiliated to Shandong University, Jinan, People s Republic of China
    J Cell Mol Med 13:4636-42. 2009
    The function of thyrotropin (TSH) in the thyroid gland is mediated by thyrotropin receptor (TSHR)...
  55. ncbi A mathematical model of pituitary--thyroid interaction to provide an insight into the nature of the thyrotropin--thyroid hormone relationship
    Melvin Khee Shing Leow
    Department of Endocrinology, Division of Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
    J Theor Biol 248:275-87. 2007
    The mathematical model proposed focuses on the description of the behavior of the interaction between thyrotropin (i.e...
  56. pmc The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor
    Sandra Mueller
    III Medical Department, University of Leipzig, Philipp Rosenthal Strasse 27, D 04103 Leipzig, Germany
    J Biol Chem 284:16317-24. 2009
    ..Moreover, the simultaneous localization of binding components in the glycoprotein hormone molecule and the receptor hinge region permits important reevaluation of interacting hormone receptor domains...
  57. ncbi Spontaneous normalization of thyrotropin concentrations in patients with subclinical hypothyroidism
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera Colmenar km 9, 28034 Madrid, Spain
    J Clin Endocrinol Metab 90:4124-7. 2005
    ..Patients with subclinical hypothyroidism may revert to normal TSH values...
  58. ncbi Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: a comparative structural study of protein-protein interactions
    R Nunez Miguel
    FIRS Laboratories, RSR Ltd, Parc Ty Glas, Llanishen, Cardiff, UK
    J Mol Endocrinol 42:381-95. 2009
    ..Furthermore, the surface area formed by TSHR residues N208, Q235, R255, and N256 has been identified as a candidate target region for small molecules which might selectively block binding of autoantibodies to the TSHR...
  59. pmc Endogenous thyrotropin and triiodothyronine concentrations in individuals with thyroid cancer
    Jacqueline Jonklaas
    Division of Endocrinology, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
    Thyroid 18:943-52. 2008
    ..Recently higher baseline thyrotropin (TSH) levels have been found to be associated with a postoperative diagnosis of differentiated thyroid cancer...
  60. ncbi Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body composition
    Gerasimos E Krassas
    Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece
    Eur J Endocrinol 153:217-21. 2005
    ..To date, very few studies have reported on resistin concentrations in hyperthyroid patients, and they present controversial results...
  61. ncbi Elevated risk of papillary thyroid cancer in Korean patients with Hashimoto's thyroiditis
    Kyung Won Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Head Neck 33:691-5. 2011
    ..The purpose of this study was whether HT was related to the risk of PTC over TSH...
  62. ncbi Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity
    Sabine Costagliola
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, ULB, 808 Lennik Street, B 1070 Brussels, Belgium
    Mol Endocrinol 18:3020-34. 2004
    ..Delineation of the conformational epitopes of these stimulating antibodies opens the way to the identification of the molecular mechanisms implicated in the activation of the TSHr...
  63. ncbi Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation
    Susanne Neumann
    III Medical Department, University of Leipzig, Germany
    Eur J Endocrinol 152:625-34. 2005
    ....
  64. pmc Evidence that the thyroid-stimulating hormone (TSH) receptor transmembrane domain influences kinetics of TSH binding to the receptor ectodomain
    Chun Rong Chen
    Thyroid Autoimmune Disease Unit, Cedars Sinai Research Institute and the David Geffen School of Medicine, UCLA, Los Angeles, California 90048, USA
    J Biol Chem 286:6219-24. 2011
    ..Our data provide the first evidence that the wild-type TSHR TMD influences ligand binding affinity for the ECD, possibly by altering the conformation of the closely associated hinge region that contributes to the TSH-binding site...
  65. pmc TNFalpha mediates the skeletal effects of thyroid-stimulating hormone
    Hidenori Hase
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:12849-54. 2006
    ..The results suggest that TNFalpha is the critical cytokine mediating the downstream antiresorptive effects of TSH on the skeleton...
  66. ncbi Serum thyrotropin concentration as a biochemical predictor of thyroid malignancy in patients presenting with thyroid nodules
    Stergios A Polyzos
    Department of Endocrinology, Hippokratio General Hospital, Thessaloniki, Greece
    J Cancer Res Clin Oncol 134:953-60. 2008
    Serum thyrotropin (TSH) is a well-established growth factor for thyroid nodules and suppression of TSH concentrations by administering exogenous thyroxine may interfere with the growth of established nodules as well as the formation of ..
  67. ncbi Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney
    Cornelia Schmutzler
    Institut für Experimentelle Endokrinologie und Endokrinologisches Forschungszentrum EnForCé, Charite, Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Toxicology 205:95-102. 2004
    ..b>Thyrotropin (TSH) and thyroid hormone (T4, T3) serum levels were altered, but not in a way consistent with known mechanisms ..
  68. pmc Age and the thyrotropin response to hypothyroxinemia
    Rebecca Over
    Division of Endocrinology, Georgetown University Medical Center, Suite 232, Building D, and Washington Hospital Center, 4000 Reservoir Road, NW, Washington, DC 20007, USA
    J Clin Endocrinol Metab 95:3675-83. 2010
    ..Some studies suggest altered pituitary functioning and TSH production with aging...
  69. ncbi Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination
    Randa M Abdulrahman
    Department of Endocrinology, C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 95:3758-62. 2010
    ..Decreased serum thyroid hormone levels during tyrosine kinase inhibitors are also observed in athyreotic patients with thyroid carcinoma. We therefore hypothesized that tyrosine kinase inhibitors may influence thyroid hormone metabolism...
  70. ncbi Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromsø Study
    A Iqbal
    Department of Cardiology, University Hospital of North Norway, Tromsø, Norway
    J Intern Med 260:53-61. 2006
    ..To evaluate the relation between serum thyroid-stimulating hormone (TSH) and lipids...
  71. pmc Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma
    Changxue Lu
    Laboratory of Molecular Biology, National Cancer Institute, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892 4264, USA
    Endocrinology 151:1929-39. 2010
    ..These in vivo findings provide new insights in understanding carcinogenesis of the human thyroid...
  72. ncbi The relationship between serum thyrotropin and components of metabolic syndrome
    Yaxin Lai
    Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No 155 Nanjing Bei Street, Heping, Shenyang, China
    Endocr J 58:23-30. 2011
    To explore the relationship between serum thyrotropin and components of metabolic syndrome in a Chinese cohort...
  73. ncbi Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment
    Rolf Jorde
    Institute of Clinical Medicine R J, K W, University of Tromsø, 9037 Tromsø, Norway
    J Clin Endocrinol Metab 91:145-53. 2006
    ..5-10.0 mIU/liter and normal serum free T4 and free T3 levels, and to study the effect of T4 supplementation...
  74. pmc TSH stimulates adipogenesis in mouse embryonic stem cells
    Min Lu
    Department of Medicine, Mount Sinai School of Medicine, Box 1055, One Gustave L Levy Place, New York, New York 10029, USA
    J Endocrinol 196:159-69. 2008
    ..It further highlights the potential of ES cells as a model system for use in the study of TSH's role in the regulation of physiologically relevant adipose tissue...
  75. ncbi Triiodothyronine levels in athyreotic individuals during levothyroxine therapy
    Jacqueline Jonklaas
    Division of Endocrinology, Georgetown University Medical Center, Washington, DC, USA
    JAMA 299:769-77. 2008
    ..However, trials evaluating therapy with combined LT4 and T3 have failed to demonstrate any consistent advantage of combination therapy...
  76. ncbi The association between serum TSH concentration and thyroid cancer
    Kristien Boelaert
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, IBR Building 2nd Floor, Birmingham, UK
    Endocr Relat Cancer 16:1065-72. 2009
    ..4 muU/ml) was associated with a reduction in the risk of papillary thyroid carcinoma. In this commentary, the evidence regarding the association between serum TSH and thyroid cancer is discussed placing these new findings into context...
  77. ncbi Recombinant human thyrotropin stimulation of fluoro-D-glucose positron emission tomography uptake in well-differentiated thyroid carcinoma
    Bennett B Chin
    Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 89:91-5. 2004
    ..02 for both). rTSH stimulation improves the detectability of occult thyroid metastases with FDG PET, compared with scans performed on TSH suppression...
  78. ncbi Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?
    Z Efstathiadou
    Division of Endocrinology, University of Ioannina School of Medicine, University Hospital of Ioannina, Ioannina, Greece
    Eur J Endocrinol 145:705-10. 2001
    ..The present study aimed to assess the association of SH with lipid abnormalities and to quantify the effect of L-thyroxine therapy on serum lipid profiles...
  79. pmc Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor
    Gunnar Kleinau
    Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
    PLoS ONE 5:e9745. 2010
    ..The thyrotropin receptor (TSHR) binds G-proteins promiscuously and activates both Gs (cAMP) and Gq (IP)...
  80. ncbi Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study
    Tuija Männistö
    Department of Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland
    J Clin Endocrinol Metab 94:772-9. 2009
    ..There are only a few large prospective studies involving evaluation of the effect of maternal thyroid dysfunction on offspring and observations are inconsistent...
  81. ncbi Comparative evaluation of therapy with L-thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism
    Malgorzata Wasniewska
    Department of Pediatrics, University of Messina, Messina, Italy
    Horm Res Paediatr 77:376-81. 2012
    ..The question of whether children with subclinical hypothyroidism (SH) should be treated or not is controversial due to the lack of studies on outcomes of SH children treated with L-thyroxine (L-T(4)) versus those receiving no therapy...
  82. ncbi Maternal hypothyroidism in early and late gestation: effects on neonatal and obstetric outcome
    Iskandar Idris
    Department of Diabetes and Endocrinology, Nottingham City Hospital, UK
    Clin Endocrinol (Oxf) 63:560-5. 2005
    ..The effects of thyroxine dose requirement during pregnancy and serum concentrations of TSH within such clinic settings are still not known...
  83. ncbi Lower neonatal screening thyroxine concentrations in down syndrome newborns
    A S P van Trotsenburg
    Department of Pediatric Endocrinology, Emma Children s Hospital AMC, 1105 AZ Amsterdam, The Netherlands
    J Clin Endocrinol Metab 88:1512-5. 2003
    ..The question remains whether this contributes to the brain maldevelopment...
  84. ncbi Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids
    Thomas Reinehr
    Vestische Kinder und Jugendklinik, University of Witten Herdecke, Dr F Steiner Strasse 5, 45711 Datteln, Germany
    J Clin Endocrinol Metab 91:3088-91. 2006
    ..There is some controversy whether T(4) treatment is indicated in obese humans with hyperthyrotropinemia...
  85. ncbi Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey
    Ravinder Goswami
    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India
    Br J Nutr 102:382-6. 2009
    ..Further studies in vitamin D-sufficient populations with wider range of serum 25(OH)D levels are required to substantiate the findings of the current study...
  86. ncbi Exposure to bisphenol A is associated with recurrent miscarriage
    Mayumi Sugiura-Ogasawara
    Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan
    Hum Reprod 20:2325-9. 2005
    ..Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities...
  87. ncbi Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism
    Erik K Alexander
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 351:241-9. 2004
    ..In this prospective study we attempted to identify precisely the timing and amount of levothyroxine adjustment required during pregnancy...
  88. ncbi Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy
    Beverley M Shields
    Peninsula National Institute for Health Research Clinical Research Facility, Peninsula Medical School, Exeter University, Exeter EX2 5DW, United Kingdom
    J Clin Endocrinol Metab 94:4608-12. 2009
    ..We aimed to assess whether genetic variation in TSH due to the rs4704397 genotype affects the number of individuals classified as having subclinical hypothyroidism in pregnancy...
  89. ncbi Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms
    Gunnar Kleinau
    Leibniz Institut fur Molekulare Pharmakologie, Berlin, Germany
    Endocr Rev 30:133-51. 2009
    ..Finally, we address the issue of structural implications and suggest a refined scenario for the initial signaling process on GPHRs...
  90. ncbi Thyrotropin suppression by metformin
    Robert A Vigersky
    Endocrinology Service, Walter Reed, Army Medical Center, Washington, DC 20307, USA
    J Clin Endocrinol Metab 91:225-7. 2006
    ..Metformin has been available in the United States for 9 yr and elsewhere for many years, but as of yet there are no reports that the drug modifies thyroid hormone economy...
  91. ncbi The role of thyroid autoimmunity in fertility and pregnancy
    Kris Poppe
    Thyroid Clinic, University Hospital, UZ Brussel, Brussels, Belgium
    Nat Clin Pract Endocrinol Metab 4:394-405. 2008
    ..Systematic screening for thyroid disorders in pregnant women remains controversial but might be advantageous in women at high risk, particularly infertile women...
  92. pmc A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine
    Vijay Panicker
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Clin Endocrinol Metab 93:3075-81. 2008
    ..We aimed to thoroughly examine the role of common variation across the three deiodinase genes in relation to thyroid hormones...
  93. ncbi Two novel mutations in the thyrotropin (TSH) receptor gene in a child with resistance to TSH
    R J Clifton-Bligh
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    J Clin Endocrinol Metab 82:1094-100. 1997
    ..Our findings indicate that a single normal TSH receptor allele is sufficient for normal thyroid function, but that the compound abnormality in the proband leads to TSH resistance...
  94. ncbi Longitudinal study of thyroid function in children with mild hyperthyrotropinemia at neonatal screening for congenital hypothyroidism
    Daniela Leonardi
    Endocrinologia Università di Catania, Ospedale Garibaldi Nesima, Via Palermo 636, Catania, Italy
    J Clin Endocrinol Metab 93:2679-85. 2008
    ..0 +/- 0.7 yr of age). In these children a high prevalence (50%) of subclinical hypothyroidism in early childhood (2.8 +/- 0.5 yr) had already been described...
  95. ncbi Association between thyroid dysfunction and total cholesterol level in an older biracial population: the health, aging and body composition study
    Alka M Kanaya
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, 1701 Divisadero St, Suite 554, San Francisco, CA 94143 1732, USA
    Arch Intern Med 162:773-9. 2002
    ..Thyroid dysfunction increases with age. Less is known about the prevalence of thyroid disease in older black adults and whether an association between thyroid function and serum cholesterol level exists, as in older white adults...
  96. ncbi Molecular cloning of the thyrotropin receptor
    M Parmentier
    Institut de Recherche Interdisciplinaire, Faculte de Medecine, Universite Libre de Bruxelles, Belgium
    Science 246:1620-2. 1989
    The pituitary hormone thyrotropin, or thyroid-stimulating hormone (TSH), is the main physiological agent that regulates the thyroid gland...
  97. ncbi Four families with loss of function mutations of the thyrotropin receptor
    N de Roux
    INSERM U 135 and Laboratoire d Hormonologie et Biologie Moléculaire Hôpital de Bicêtre, Le Kremlin, France
    J Clin Endocrinol Metab 81:4229-35. 1996
    ..The Phe525 Leu substitution also markedly impaired adenylate cyclase activation, underlining the importance of the second intracellular loop in receptor signaling...
  98. ncbi Circulating thyroid hormone concentrations and placental thyroid hormone receptor expression in normal human pregnancy and pregnancy complicated by intrauterine growth restriction (IUGR)
    M D Kilby
    Department of Fetal Medicine, University of Birmingham, Edgbaston, United Kingdom
    J Clin Endocrinol Metab 83:2964-71. 1998
    ....
  99. ncbi TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study)
    C Meier
    Division of Endocrinology, Department of Central Laboratories, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    J Clin Endocrinol Metab 86:4860-6. 2001
    ..An important risk reduction of cardiovascular mortality of 9-31% can be estimated from the observed improvement in low density lipoprotein cholesterol...
  100. pmc Do traditional symptoms of hypothyroidism correlate with biochemical disease?
    G J Canaris
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198 3331, USA
    J Gen Intern Med 12:544-50. 1997
    ..To determine the relation between symptoms and biochemical disease, we assessed symptoms and serum thyroid function tests, concurrently, for patients with and without hypothyroidism...
  101. pmc Impact of smoking and thiocyanate on perchlorate and thyroid hormone associations in the 2001-2002 national health and nutrition examination survey
    Craig Steinmaus
    Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, California 94612, USA
    Environ Health Perspect 115:1333-8. 2007
    ..Decreases in thyroid hormone seen with perchlorate exposure could be even greater in people with concomitant exposure to agents such as thiocyanate that may affect the thyroid by mechanisms similar to those of perchlorate...

Research Grants65

  1. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS), my research has focused on the regulation of thyrotropin-releasing hormone (TRH) expression in the paraventricular nucleus of the hypothalamus (PVH) by both thyroid ..
  2. ANIMAL MODELS OF HYPERTHYROIDISM
    Sandra M McLachlan; Fiscal Year: 2012
    ..Graves'disease, a common disorder, has an unusual etiology: the immune system targets one molecule, the thyrotropin receptor (TSHR), autoantibodies mediate disease, and the target organ is stimulated not destroyed...
  3. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2009
    ..One very important energy expenditure regulator Thyrotropin Releasing Hormone (TRH) is produced in the paraventricular nucleus (PVN) of the hypothalamus...
  4. Developmental defects in serotonin neurons and the response to O2 and CO2
    George B Richerson; Fiscal Year: 2011
    ..Finally, using in vivo, perfused brain and brain slice preparations, we will determine whether serotonin or thyrotropin releasing hormone can restore normal breathing in adult Lmxlb conditional knockout mice...
  5. Immunoglobulin Activation of Fibroblasts
    Terry J Smith; Fiscal Year: 2012
    ..and environmental factors where the thyroid becomes overactive because antibodies (TSI) directed against the thyrotropin receptor (TSHR) drive excess hormone production...
  6. Role of Oleylethanolamine in the Regulation of the HPT Axis
    Csaba Fekete; Fiscal Year: 2010
    ..to fasted rats on the gene expression of feeding-related peptides in the hypothalamic arcuate nucleus and on thyrotropin-releasing hormone (TRH) mRNA levels in the hypothalamic paraventricular nucleus (PVN) using semiquantitative in ..
  7. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
    b>Thyrotropin-releasing hormone (TRH) produced by neurons in the hypothalamic paraventricular nucleus (PVN) has an important role in the regulation of energy homeostasis by establishing circulating levels of thyroid hormone under normal ..
  8. Neuroendocrine Control of Glucose Metabolism
    Gregory J Morton; Fiscal Year: 2013
    ..Moreover, we hypothesize that leptin-induced activation of a subset of thyrotropin-releasing hormone (TRH) neurons in the paraventricular nucleus (PVN) stimulates glucose uptake, and thereby ..
  9. GENETIC SUSCEPTIBILITY TO GRAVES'-LIKE HYPERTHYROIDISM IN MICE
    Sandra M McLachlan; Fiscal Year: 2013
    ..by applicant): Graves'hyperthyroidism is caused by thyroid stimulating autoantibodies (TSAb) to the thyrotropin receptor (TSHR)...
  10. TSH RECEPTOR MULTIMERIZATION
    TERRY FRANCIS DAVIES; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The thyrotropin receptor (TSHR), expressed on the plasma membrane of thyroid epithelial cells as well as a variety of extra-thyroidal sites, is central to the regulation of thyroid growth and ..
  11. Sim1 Neurons and Body Weight Regulation
    Qingchun Tong; Fiscal Year: 2013
    ....
  12. REGULATION OF RETROOCULAR CONNECTIVE TISSUE
    Terry J Smith; Fiscal Year: 2013
    ..Unexpectedly we found that fibrocytes and orbit-infiltrating CD34+ fibroblasts express thyrotropin receptor (TSHR), the central autoantigen in GD...
  13. RAPIDLY-ACTING TREATMENTS FOR TREATMENT-RESISTANT DEPRESSION (RAPID)
    Maurizio Fava; Fiscal Year: 2011
    ..other than Ketamine Hydrochloride), allosteric modulators of AMPA receptors, 5HT4 receptor compounds, Thyrotropin-Releasing Hormone (TRH)) or non-pharmacologic interventions other than sleep deprivation (e.g., TMS, ECT, MST)...
  14. THE THYROTHROPIN RECEPTOR IN HEALTH AND DISEASE
    Basil Rapoport; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PROJECT SUMMARY The thyrotropin receptor (TSHR) plays a vital role in thyroid physiology and pathophysiology...
  15. Sensory processing of social and defensive chemosignals
    Catherine G Dulac; Fiscal Year: 2013
    ..the responses of two complementary populations of neurons expresing either the enzyme aromatase (Ar) or thyrotropin-releasing hormone (TRH that are located in distinct areas of the MeA reported to drive mating and defensive ..
  16. New Targets of Thyroid Hormone Action
    Anthony N Hollenberg; Fiscal Year: 2013
    ..Remarkably, TH action in humans is determined almost exclusively by the use of the thyrotropin (TSH) assay which depends only upon TH action at the level of the hypothalamus and pituitary...
  17. Subclinical Hypothyroidism: Mood, Cognition and the effect of L-thyroxine treatme
    Robert A Stern; Fiscal Year: 2012
    Abstract Subclinical hypothyroidism is a biochemical diagnosis characterized by elevated thyrotropin (TSH) levels with normal circulating thyroxine (T4) and triiodothyronine (T3) levels...
  18. Planning a Multi-center Trial of Subclinical Hypothyroidism in Older Adults
    Douglas C Bauer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Overt hypothyroid is defined as an elevated pituitary thyrotropin (TSH) and corresponding low thyroid hormone levels, while the much more common entity, subclinical hypothyroidism (SCH), is defined ..
  19. MOLECULAR MECHANISMS OF THYROID HORMONE ACTION
    Fredric E Wondisford; Fiscal Year: 2013
    ..central regulation of the hypothalamic- pituitary-thyroid axis (HPT axis) by thyroid hormones (T4 and T3) and thyrotropin-releasing hormone (TRH)...
  20. MULTIDIMENSIONAL HORMONAL ASSESSMENT OF PTSD
    Sheila Wang; Fiscal Year: 1999
    ..study will employ a group comparison design with six dependent measures: total T3, free T3, total T4, free T4, thyrotropin (TSH), and thyroxine-binding globulin (TBG)...
  21. MOLECULAR BASIS FOR ETHANOL-INDUCED HYPOTHYROIDISM
    Robert Zoeller; Fiscal Year: 1993
    ..However, cellular levels of mRNA encoding thyrotropin-releasing hormone (TRH) in neurons of the paraventricular nucleus ...
  22. MECHANISM OF TRH EFFECTS IN FETAL LUNG DEVELOPMENT
    UDAY DEVASKAR; Fiscal Year: 1999
    HMD and BPD remain the major causes of neonatal mortality and norbidity. Maternal Thyrotropin Releasing Hormone (TRH) treatment enhances fetal lung maturation, but inhibits antioxidant enzyme (AOE)...
  23. Thyrotropin Receptor Autoantibodies in Graves'Ophthalmopathy
    Rebecca S Bahn; Fiscal Year: 2012
    ..Our laboratory has recently established a role for thyrotropin receptor (TSHR) autoantibodies in the initiation of these changes...
  24. TRH in mediating the bradycardia of caloric restriction
    Steven Swoap; Fiscal Year: 2005
    ..The following specific aims will address important questions in cardiovascular biology concerning the roles of thyrotropin releasing hormone, thyroid hormones, the parasympathetic nervous system, and the sympathetic nervous system in ..
  25. BRAIN REGULATING GASTRIC ACID FUNCTION BY NEUROPEPTIDES
    YVETTE TACHE; Fiscal Year: 2000
    b>Thyrotropin-releasing hormone (TRH) and somatostatin are among the peptides which induce a vagal-dependent stimulation of gastric function when injected into the dorsal motor nucleus (DMN) of the vagus...
  26. Hypothalamic Type 2 Deiodinase in Metabolism Regulation
    Sabrina Diano; Fiscal Year: 2005
    ..region with minimal activity in the paraventricular nucleus where the central thyroid-regulating neurons, the thyrotropin releasing hormone (TRH)-containing cells are located...
  27. MOLECULAR ENDOCRINOLOGY OF THE UTERUS
    Elizabeth Stewart; Fiscal Year: 2001
    ..of a family of dimeric hormones including luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyrotropin (TSH), that share a common alpha subunit and have unique beta-subunits...
  28. CENTRAL RESISTANCE TO THYROID HORMONE
    JOSHUA SAFER; Fiscal Year: 2000
    ..Patients with generalized resistance (GRTH) display inappropriate secretion of thyrotropin (TSH) from the anterior pituitary and abnormal peripheral tissue response to thyroid hormone...
  29. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD LECHAN; Fiscal Year: 2007
    The long term goals of this program are to elucidate mechanisms of control of thyrotropin-releasing hormone (TRH)-producing neurons in the hypothalamic paraventricular nucleus (PVN) that comprise a critical component of the hypothalamic-..
  30. OPHTHALMOPATHY OF GRAVES DISEASE
    Juan Jaume; Fiscal Year: 2001
    ..The primary goal of the project is to test the hypothesis that the human thyrotropin receptor (TSHR) is the elusive antigenic target of the immune response in Graves' ophthalmopathy...
  31. Thyrotrope Proliferation by Thyroid Hormone
    ELI RIDGWAY; Fiscal Year: 2006
    ..The thyrotrope cell represents one of the cells in the anterior pituitary and its function is to produce thyrotropin which is secreted into the circulation and regulates the growth and function of the thyroid gland which ..
  32. HORMONAL REGULATION OF THYROGLOBULIN GENE IN THYROIDS
    Chi Bom Chae; Fiscal Year: 1991
    ..The differentiated functions of the thyroid gland are regulated mainly by the pituitary gland hormone, thyrotropin (TSH)...
  33. G Protein-Coupled Receptors with Leucine-Rich Repeats
    Aaron Hsueh; Fiscal Year: 2002
    ..Among this group of proteins, the thyrotropin and gonadotropin receptors represent a subfamily with important functions in thyroid and gonads, respectively...
  34. TRH AND GLUCOCORTICOID ACTIONS ON THE FETAL LUNG
    Peter Nathanielsz; Fiscal Year: 2000
    ..7 GA). Animal studies, mostly sheep and rabbits, suggest that combined therapies with thyrotropin releasing hormone (TRH) and GC may be of benefit at 0.7 GA...
  35. STRUCTURE/FUNCTION RELATIONSHIPS OF HUMAN THYROTROPIN
    Bruce Weintraub; Fiscal Year: 2000
    The objective of this proposal is the elucidation of the structure- function relationships of human thyrotropin (hTSH) and its receptor by developing and characterizing the action of novel analogs with enhanced binding affinity, in vitro ..
  36. PIT-1T AND THYROTROPIN BETA SUBUNIT GENE EXPRESSION
    BRYAN HAUGEN; Fiscal Year: 1999
    ....
  37. IN VIVO ANALYSIS OF THYROID HORMONE ACTION
    EVAN ABEL; Fiscal Year: 2001
    ..are tightly regulated via a feedback loop involving thyroid stimulating hormone (TSH) from the pituitary and thyrotropin releasing hormone (TRH) from the hypothalamus; increasing levels of thyroid hormone will inhibit the production ..
  38. Role of Carbohydrate in the Sorting of LH and FSH
    Irving Boime; Fiscal Year: 2006
    The human pituitary, hormones lutropin (LH), follitropin (FSH) and thyrotropin constitute a family of glycoprotein heterodimers comprised of a common alpha-subunit and a hormone-specific beta-subunit...
  39. MOLECULAR BASIS OF CONGENITAL THYROTROPIN DEFICIENCY
    JOHN FYFE; Fiscal Year: 2001
    ..has been no animal model of pituitary CH from which one might gain insight into such issues as the loss of thyrotropin-releasing hormone (TRH)-mediated functions in organs other than the pituitary gland...
  40. CHARACTERIZATION OF HYPOTHALAMO-LYMPHO--THYROID AXIS
    LEE NIEN CHAN; Fiscal Year: 1992
    ..b>Thyrotropin (TSH) is a pituitary molecule regulated positively by thyrotropin releasing hormone (TRH) and negatively by ..
  41. HYPOTHYROXINEMIA OF PREMATURITY AND NEURODEVELOPMENT
    MARY REUSS; Fiscal Year: 1993
    ..Hypothyroxinemia, associated with normal or low thyrotropin levels, occurs in 15-80% of premature infants, depending on the gestational age(1-8)...
  42. GLYCOPROTEIN HORMONE OLIGOSACCHARIDES
    JACQUES BAENZIGER; Fiscal Year: 2006
    ..We have previously demonstrated that the N-linked carbohydrates on the glycoprotein hormones lutropin (LH) and thyrotropin (TSH) from all vertebrate species terminate with this unique sulfated structure...
  43. BRAIN TARGETING OF THYROTROPIN RELEASING HORMONE ANALOGS
    Laszlo Prokai; Fiscal Year: 2002
    b>Thyrotropin-releasing hormone (TRH) analogues offer potential treatment of various maladies of the central nervous system (associated mainly with cholinergic hypofunction due to motorneuron diseases, Alzheimer's disease, ..
  44. MOLECULAR BASIS OF HYPOPITUITARISM IN MAN
    LAURIE COHEN; Fiscal Year: 1999
    ..Pit-1 is also important for hormonal regulation of the Prl and thyrotropin beta subunit (TSH-beta) genes by thyrotropin-releasing hormone (TSH-beta) and cyclic AMP (cAMP)...
  45. THE ROLE OF PREPROTRH PEPTIDES IN COCAINE ACTION
    Kevin Sevarino; Fiscal Year: 2004
    ..In the proposed studies, these behavioral endpoints are used to characterize the role of the peptide thyrotropin-releasing hormone (TRH), and other peptides derived from the TRH precursor, in rat models of cocaine addiction...
  46. INHALED NO IN PREVENTION OF CHRONIC LUNG DISEASE
    Scott Lorch; Fiscal Year: 2004
    ..A number of other approaches, including antenatal thyrotropin releasing hormone in conjunction with corticosteroids, postnatal steroid administration, as well as ..
  47. THYROID FUNCTION IN THE FETUS AND NEWBORN
    Delbert Fisher; Fiscal Year: 1993
    ..for human precocial development; specifically we study 1) the ontogenesis, metabolism, and role of extraneural thyrotropin releasing hormone (TRH) in fetal thyroid function, 2) the ontogenesis of thyroid hormone receptors and ..
  48. TRH AND TRH-RELATED PEPTIDES AND TESTIS
    Pei Feng; Fiscal Year: 1999
    b>Thyrotropin-releasing hormone (TRH) from hypothalamus is the major regulator of TSH synthesis and secretion. Most recently, TRH and ppTRH mRNA have been identified in rat testis...
  49. MULTIPONTENTIAL DRUG TREATMENT STRATEGIES IN NEUROTRAMA
    ALAN FADEN; Fiscal Year: 2002
    ..The tripeptide, thyrotropin releasing hormone (TRH), modulates multiple components of the secondary injury cascade and treatment with TRH ..
  50. DEVELOPMENT OF BRAINSTEM NEUROTRANSMITTER SYSTEMS
    DOUGLAS BAYLISS; Fiscal Year: 1999
    ..To this end, the effects on HMs of three transmitters synthesized by raphe cells [i.e., serotonin (5-HT), thyrotropin-releasing hormone (TRH), and substance P (SP)] are determined during postnatal development and correlated with ..
  51. MECHANISM OF TRH SIGNALING PATHWAYS MEDIATED BY PIT-1
    Fredric Wondisford; Fiscal Year: 2000
    This proposal addresses the molecular mechanism of thyrotropin-releasing hormone TRH, acting through its cell membrane receptor, modulates the phosphorylation state of a pituitary-specific transcription factor, Pit-I...
  52. METABOLIC SIMILARITIES IN LONG LIVED MODELS
    Gretchen Darlington; Fiscal Year: 1999
    ..These mutant mice have pituitary insufficiency leading to reduced growth hormone, prolactin, and thyrotropin. The df mouse model has a dramatically extended life span--the greatest extension of any mammalian model (Brown-..
  53. THYROTROPIN RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
    Xin Yun Huang; Fiscal Year: 2003
    ..define at the molecular level the mechanism(s) and regulation of signal transduction by the two receptors for thyrotropin-releasing hormone (TRH-R1 and TRH-2)...
  54. CELL AND MOLECULAR BIOLOGY OF THE TRH RECEPTOR
    Thomas Graves; Fiscal Year: 2001
    The pituitary receptor for the hypothalamic peptide thyrotropin releasing hormone (TRH) is a G-protein coupled, calcium-mobilizing receptor...
  55. THYROTROPIN BETA SUBUNIT GENE TRANSCRIPTION FACTORS
    ELI RIDGWAY; Fiscal Year: 2006
    b>Thyrotropin (TSH) is the pituitary glycoprotein hormone, which controls the growth and function of the thyroid gland. It is produced solely by thyrotrope cells, one of five terminally differentiated pituitary cell types...
  56. NEUROCHEMICAL INTEGRATION OF RESPIRATION IN THE NTS
    Scott Manaker; Fiscal Year: 1993
    Serotonin (5HT), thyrotropin releasing hormone (TRH) and substance P (SP) are three neurotransmitters with important central effects upon the control of respiration...
  57. PROTRH DERIVED PEPTIDES DURING OPIATE WITHDRAWAL
    RONALD LECHAN; Fiscal Year: 1999
    ..region of the midbrain periaqueductal gray (PAG) show a marked increase (approximately 500%) in pro-thyrotropin-releasing hormone (proTRH) gene expression during opiate withdrawal...
  58. TRH METABOLISM IN GERIATRIC DEPRESSION
    GABRIEL TSUBOYAMA; Fiscal Year: 1999
    ..Specifically, Dr. Tsuboyama will investigate both the thyrotropin (TSH) response to thyrotropin-releasing hormone (TRH) and the metabolism of TRH in geriatric depressed patients...
  59. SECRETION OF TRH & OTHER NEURAL PEPTIDES
    Ivor Jackson; Fiscal Year: 1991
    ....
  60. THYROTROPIN-RELEASING HORMONE--STUDY OF GENE EXPRESSION
    Anthony Hollenberg; Fiscal Year: 1999
    Our work on the hormonal regulation of the human thyrotropin-releasing hormone (TRH) gene has identified a novel thyroid hormone response element through which thyroid hormone inhibits TRH production at the transcriptional level...
  61. SIGNIFICANCE OF THE TRH IN EPILEPSY
    MICHAEL KUBEK; Fiscal Year: 1990
    The long-term objective of this research program is to define the role of thyrotropin-releasing hormone (TRH) in the pathophysiology of epilepsy...
  62. CROSSTALK BETWEEN CAMP AND RAS IN ENDOCRINE CELLS
    Judy Meinkoth; Fiscal Year: 2001
    ..In thyrocytes, pituitary somatotrophs and other cells, cAMP stimulates proliferation. We discovered that thyrotropin (TSH) stimulates proliferation through a novel pathway involving both Ras and the cAMP-dependent protein kinase,..
  63. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2007
    ..Pearce's career as an independent academic clinical investigator with a focus on thyroid disease and epidemiology. ..
  64. Mentored Patient-Oriented Research Career Development Award
    Jacqueline Jonklaas; Fiscal Year: 2006
    ..A new sustained release product, which results in steady triiodothyronine levels, will furnish more physiologic replacement. This will be tested against treatment with levothyroxine, and levothyroxine and triiodothyronine. ..
  65. Thyrotropin Receptor Auto Antibodies in Graves' Ophthalmopathy
    Rebecca S Bahn; Fiscal Year: 2010
    ..investigations in this proposal is to determine mechanisms involved in the stimulation of adipogenesis by thyrotropin receptor (TSHR)-directed autoantibodies (TRAb) in GO orbital preadipocytes...