growth hormone

Summary

Summary: A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.

Top Publications

  1. pmc Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse
    Edward O List
    The Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701, USA
    Endocr Rev 32:356-86. 2011
  2. pmc Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver
    Yijing Zhang
    Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, Massachusetts, USA
    Mol Cell Biol 32:880-96. 2012
  3. ncbi Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells
    Enyi Huang
    School of Bioengineering, Chongqing University, Chongqing, China
    J Bone Miner Res 27:1566-75. 2012
  4. ncbi Dwarf mice and the ageing process
    H M Brown-Borg
    Nature 384:33. 1996
  5. pmc Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 8:77-83. 2008
  6. ncbi Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice
    Andrzej Bartke
    Departments of Physiology and Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794 9628, USA
    Neuroendocrinology 78:210-6. 2003
  7. pmc Growth hormone, insulin-like growth factors, and the skeleton
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Endocr Rev 29:535-59. 2008
  8. ncbi The somatomedin hypothesis: 2001
    D Le Roith
    Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocr Rev 22:53-74. 2001
  9. pmc Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
    Tong Jin Zhao
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:7467-72. 2010
  10. ncbi Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth
    F Lupu
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Dev Biol 229:141-62. 2001

Detail Information

Publications385 found, 100 shown here

  1. pmc Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse
    Edward O List
    The Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701, USA
    Endocr Rev 32:356-86. 2011
    ..We have attempted to present the findings in the context of current knowledge regarding GH action and, where applicable, to discuss how these mice compare to GH insensitivity syndrome in humans...
  2. pmc Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver
    Yijing Zhang
    Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, Massachusetts, USA
    Mol Cell Biol 32:880-96. 2012
    Sex-dependent pituitary growth hormone (GH) secretory patterns determine the sex-biased expression of >1,000 genes in mouse and rat liver, affecting lipid and drug metabolism, inflammation, and disease...
  3. ncbi Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells
    Enyi Huang
    School of Bioengineering, Chongqing University, Chongqing, China
    J Bone Miner Res 27:1566-75. 2012
    b>Growth hormone (GH) is usually released by somatotrophs in the anterior pituitary in response to the GH-releasing hormone and plays an important role in skeleton development and postnatal growth...
  4. ncbi Dwarf mice and the ageing process
    H M Brown-Borg
    Nature 384:33. 1996
  5. pmc Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 8:77-83. 2008
    Starvation blocks the actions of growth hormone (GH) and inhibits growth through mechanisms that are not well understood...
  6. ncbi Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice
    Andrzej Bartke
    Departments of Physiology and Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794 9628, USA
    Neuroendocrinology 78:210-6. 2003
    Overexpression of heterologous growth hormone (GH) in transgenic mice results in numerous phenotypic effects, including a drastically shortened life span...
  7. pmc Growth hormone, insulin-like growth factors, and the skeleton
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Endocr Rev 29:535-59. 2008
    ..GH and IGF-I secretion are decreased in aging individuals, and abnormalities in the GH/IGF-I axis play a role in the pathogenesis of the osteoporosis of anorexia nervosa and after glucocorticoid exposure...
  8. ncbi The somatomedin hypothesis: 2001
    D Le Roith
    Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocr Rev 22:53-74. 2001
    ..Thus, the normal postnatal growth and development in these animals may be due to normal free IGF-I levels (from as yet unidentified sources), although the role of autocrine/paracrine IGF-I has yet to be determined...
  9. pmc Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
    Tong Jin Zhao
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:7467-72. 2010
    ..to proghrelin, which is processed to ghrelin, an octanoylated peptide hormone that stimulates release of growth hormone (GH) from pituitary cells...
  10. ncbi Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth
    F Lupu
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Dev Biol 229:141-62. 2001
    To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing phenotypes manifested in mouse mutants lacking GH receptor, ..
  11. pmc Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy
    Clint Gray
    Liggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    PLoS ONE 8:e53505. 2013
    ..We have utilised a model of maternal undernutrition to examine the effects of pre-weaning growth hormone (GH) treatment on BP and vascular function in adulthood...
  12. ncbi Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study
    Jean Claude Carel
    Department of Pediatric Endocrinology and Diabetology, Institut National de la Santé et de la Recherche Mdicale CIE5, Paris, France
    J Clin Endocrinol Metab 97:416-25. 2012
    Little is known about the long-term health of subjects treated with GH in childhood, and Safety and Appropriateness of Growth hormone treatments in Europe (SAGhE) is a study addressing this question.
  13. ncbi Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children
    Pinchas Cohen
    Pediatric Endocrinology, Mattel Children s Hospital at University of California, Los Angeles, 10833 Le Conte Avenue, MDCC 22 315, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 95:2089-98. 2010
    ..We recently showed that, in IGF-based GH therapy, the IGF-I target chosen affects GH dose requirements, and higher IGF-I targets are associated with more robust growth parameters...
  14. pmc Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5
    Rosana D Meyer
    Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Mol Endocrinol 23:1914-26. 2009
    ..Bcl6 and STAT5 binding are thus inversely coordinated by the endogenous pulses of pituitary GH release, suggesting this male-specific transcriptional repressor modulates hepatic GH signaling to select STAT5 target genes...
  15. ncbi Effects of cadmium and zinc on plasma levels of growth hormone, insulin-like growth factor I, and insulin-like growth factor-binding protein 3
    Sebahat Turgut
    Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    Biol Trace Elem Res 108:197-204. 2005
    ..We also aimed to observe the effects of both Cd and Zn on the plasma levels of growth hormone (GH), insulin-like growth factor I (IGF-I), and insulin-like growth factor-binding protein 3 (IGFBP-3) in this ..
  16. pmc Insulin sensitivity as a key mediator of growth hormone actions on longevity
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Gerontol A Biol Sci Med Sci 64:516-21. 2009
    ..Here we report that in studies of calorie restriction (CR) effects in mutant (Prop1(df) and growth hormone receptor knockout [GHRKO]) and normal mice, insulin sensitivity was strongly associated with longevity...
  17. pmc Circulating levels of IGF-1 directly regulate bone growth and density
    Shoshana Yakar
    Section on Cellular and Molecular Physiology, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 110:771-81. 2002
    ....
  18. ncbi Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions
    David L Kleinberg
    Neuroendocrine Unit, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Endocr Rev 30:51-74. 2009
    ....
  19. pmc Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4679-84. 2004
    Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the pulsatile pattern of GH-release in the elderly, and increase lean but not fat mass in obese subjects...
  20. ncbi Growth hormone-induced alterations in the insulin-signaling system
    Fernando P Dominici
    Instituto de Química y Fisicoquímica Biológicas UBA CONICET, Facultad de Farmacia y Bioquimica, Junin 956 1113, Buenos Aires, Argentina
    Exp Biol Med (Maywood) 227:149-57. 2002
    b>Growth hormone (GH) counteracts insulin action on lipid and glucose metabolism. However, the sequence of molecular events leading to these changes is poorly understood...
  21. ncbi The obese Göttingen minipig as a model of the metabolic syndrome: dietary effects on obesity, insulin sensitivity, and growth hormone profile
    T Johansen
    Novo Nordisk A/S, , , Denmark
    Comp Med 51:150-5. 2001
    ..to dual energy x-ray absorptiometry (DEXA) scanning, intravenous glucose tolerance testing (IVGTT), and 6-h growth hormone profile recording. After treatment, mean body weight of pigs of the LFE group was 21.0 +/- 0.4 kg, and was 26...
  22. ncbi Consequences of growth hormone (GH) overexpression and GH resistance
    A Bartke
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512, USA
    Neuropeptides 36:201-8. 2002
    ..These studies also provided novel and still-disputed evidence for involvement of somatotropic axis in the control of aging and life span and in mediating the actions of longevity genes...
  23. ncbi Growth hormone regulation of sex-dependent liver gene expression
    David J Waxman
    Department of Biology, Boston University, 5 Cummington Street, Boston, Massachusetts 02215, USA
    Mol Endocrinol 20:2613-29. 2006
    ....
  24. ncbi Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b
    Joachim Woelfle
    Molecular Medicine Division, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Biol Chem 278:22696-702. 2003
    Many of the effects of growth hormone (GH) are mediated by insulin-like growth factor-I (IGF-I), a secreted peptide whose gene transcription is induced by GH by unknown mechanisms...
  25. ncbi Computational alanine scanning of the 1:1 human growth hormone-receptor complex
    Shuanghong Huo
    Department of Pharmaceutical Chemistry, University of California, San Francisco 94143 0446, USA
    J Comput Chem 23:15-27. 2002
    The MM-PBSA (Molecular Mechanics-Poisson-Boltzmann surface area) method was applied to the human Growth Hormone (hGH) complexed with its receptor to assess both the validity and the limitations of the computational alanine scanning ..
  26. pmc Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice
    Kristina M Mueller
    Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria
    Hepatology 54:1398-409. 2011
    b>Growth hormone (GH)-activated signal transducer and activator of transcription 5 (STAT5) and the glucocorticoid (GC)-responsive glucocorticoid receptor (GR) are important signal integrators in the liver during metabolic and physiologic ..
  27. ncbi Final height in short children born small for gestational age treated with growth hormone
    Jovanna Dahlgren
    Goteborg Pediatric Growth Research Center, Institute for the Health of Women and Children, The Sahlgrenska Academy at Goteborg University, 416 85 Goteborg, Sweden
    Pediatr Res 57:216-22. 2005
    ..The younger, shorter, and lighter the child at the start of GH treatment, the better the response. Moreover, most of these SGA individuals treated with GH reach their target height...
  28. ncbi Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice
    Daniel G Blackmore
    Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
    Stem Cells 27:2044-52. 2009
    ..Importantly, and consistent with the demonstrated ability of growth hormone (GH) to increase NSC proliferation, and the elevated secretion of GH during exercise, exercise failed to ..
  29. ncbi A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
    Laura J Niedernhofer
    Center for Biomedical Genetics Medical Genetic Center Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Nature 444:1038-43. 2006
    ..mice indicate increased cell death and anti-oxidant defences, a shift towards anabolism and reduced growth hormone/insulin-like growth factor 1 (IGF1) signalling, a known regulator of lifespan...
  30. pmc Mapping the growth hormone--Stat5b--IGF-I transcriptional circuit
    Peter Rotwein
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Trends Endocrinol Metab 23:186-93. 2012
    b>Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert powerful influences on somatic growth, metabolism, and tissue repair, and have been implicated in aging and carcinogenesis...
  31. pmc SOCS2 negatively regulates growth hormone action in vitro and in vivo
    Christopher J Greenhalgh
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research WEHI and the Cooperative Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    J Clin Invest 115:397-406. 2005
    ..Here we show that the SOCS2-/- phenotype is dependent upon the presence of endogenous growth hormone (GH) and that treatment with exogenous GH induced excessive growth in mice lacking both endogenous GH and ..
  32. ncbi A receptor in pituitary and hypothalamus that functions in growth hormone release
    A D Howard
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Science 273:974-7. 1996
    Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release...
  33. pmc Defining the epigenetic actions of growth hormone: acute chromatin changes accompany GH-activated gene transcription
    Dennis J Chia
    Department of Pediatrics, Oregon Health and Science University, Portland Oregon 97239 3098, USA
    Mol Endocrinol 24:2038-49. 2010
    ..We conclude that GH actions induce rapid and dramatic changes in hepatic chromatin at target promoters and propose that the chromatin signature of Igf1 differs from other GH-and Stat5b-dependent genes...
  34. ncbi Signal transducer and activator of transcription (Stat) 5b-mediated inhibition of insulin-like growth factor binding protein-1 gene transcription: a mechanism for repression of gene expression by growth hormone
    Mitsuru Ono
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 Southwest Sam Jackson Road, Portland, Oregon 97239, USA
    Mol Endocrinol 21:1443-57. 2007
    ....
  35. ncbi Fatal outcome of sleep apnoea in PWS during the initial phase of growth hormone treatment. A case report
    Urs Eiholzer
    Foundation Growth Puberty Adolescence, Zurich, Switzerland
    Horm Res 58:24-6. 2002
    ....
  36. ncbi Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement
    A M Ahmad
    Department of Diabetes and Endocrinology, Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK
    Clin Endocrinol (Oxf) 54:709-17. 2001
    Adult growth hormone deficiency (AGHD) is characterized by abnormalities in body composition and a poor perceived quality of life (QoL)...
  37. pmc Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development
    Kristina M Mueller
    Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria
    Mol Cell Endocrinol 361:1-11. 2012
    b>Growth hormone (GH) and glucocorticoids (GCs) are involved in the control of processes that are essential for the maintenance of vital body functions including energy supply and growth control...
  38. ncbi Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action
    Jennifer Rieusset
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Endocrinol 18:2363-77. 2004
    ....
  39. pmc Growth hormone responsive neural precursor cells reside within the adult mammalian brain
    Daniel G Blackmore
    Queensland Brain Institute, The University of Queensland, Brisbane Queensland, 4072, Australia
    Sci Rep 2:250. 2012
    The detection of growth hormone (GH) and its receptor in germinal regions of the mammalian brain prompted our investigation of GH and its role in the regulation of endogenous neural precursor cell activity...
  40. ncbi Structure and regulation of the growth hormone secretagogue receptor
    S Petersenn
    Division of Endocrinology, Medical Center, University of Essen, Essen, Germany
    Minerva Endocrinol 27:243-56. 2002
    Synthetic growth hormone secretagogues (GHS) stimulate growth hormone release through binding to a recently cloned specific growth hormone secretagogue receptor (GHS-R)...
  41. ncbi Withdrawal of long-term physiological growth hormone (GH) administration: differential effects on bone density and body composition in men with adult-onset GH deficiency
    B M Biller
    Neuroendocrine Unit and General Clinical Research Center, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    J Clin Endocrinol Metab 85:970-6. 2000
    ..Therefore, there is a critical differential response of the duration of GH action on different body composition compartments. Physiological GH administration has a persistent effect on bone mass 18 months after discontinuation of GH...
  42. ncbi Single nucleotide polymorphisms in the growth hormone-insulin-like growth factor axis in straightbred and crossbred Angus, Brahman, and Romosinuano heifers: population genetic analyses and association of genotypes with reproductive phenotypes
    P Luna-Nevarez
    Department of Animal and Range Sciences, New Mexico State University, Las Cruces 88003, USA
    J Anim Sci 89:926-34. 2011
    ....
  43. pmc Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2
    Brandon C Sos
    Cardiovascular Research Institute, UCSF, San Francisco, California 94158 9001, USA
    J Clin Invest 121:1412-23. 2011
    ..Mice with hepatocyte-specific disruption of growth hormone (GH) signaling develop fatty liver (FL), although the precise mechanism underlying this finding remains ..
  44. ncbi Comparative analysis of CNS populations in knockout mice with altered growth hormone responsiveness
    Mark I Ransome
    Neural Regeneration Laboratory, Centre for Neuroscience, University of Melbourne, Melbourne, Victoria 3010, Australia
    Eur J Neurosci 19:2069-79. 2004
    Recently we have shown that growth hormone (GH) inhibits neuronal differentiation and that this process is blocked by suppressor of cytokine signalling-2 (SOCS2)...
  45. ncbi Promoter shuffling has occurred during the evolution of the vertebrate growth hormone gene
    N A Chuzhanova
    Department of Computer Science, University of Wales, CF24 3XF, Cardiff, UK
    Gene 254:9-18. 2000
    ..study by using the novel technique of complexity analysis to identify modular components ('blocks') in the growth hormone (GH) gene promoter sequences of some 22 vertebrate species, from salmon to human...
  46. pmc Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models
    Darlene E Berryman
    School of Human and Consumer Sciences, College of Health and Human Services, Ohio University, Athens, OH 45701, United States
    Growth Horm IGF Res 18:455-71. 2008
    ..Consistently, two interventions, caloric restriction and repression of the growth hormone (GH)/insulin-like growth factor-1/insulin axis, have been shown to increase lifespan in both invertebrates and ..
  47. ncbi Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span
    Karen T Coschigano
    Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701, USA
    Endocrinology 144:3799-810. 2003
    ..Finally, life span was significantly extended for the GHR -/- mice but remained unchanged for GHA dwarfs. These results suggest that the degree of blockade of GH signaling can lead to dramatically different phenotypes...
  48. ncbi Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects
    M I Gallego
    Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Dev Biol 229:163-75. 2001
    ..We now demonstrate that not only Prl, but also growth hormone (GH) and epidermal growth factor (EGF), can activate Stat5 in mammary tissue...
  49. pmc Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood
    Claudia Sanchez-Cardenas
    Department of Endocrinology, Institute of Functional Genomics, 34094 Montpellier, France
    Proc Natl Acad Sci U S A 107:21878-83. 2010
    ..However, the recognition that growth hormone (GH) cells are arranged in functionally organized networks raises the possibility that the responses of the ..
  50. pmc Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion
    Susana Sangiao-Alvarellos
    Department of Medicine, School of Health Science, University of A Coruna, A Coruna, Spain
    Endocrinology 150:4562-74. 2009
    ....
  51. pmc LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice
    Thierry Touvier
    Universite Lille Nord de France, Lille, France
    J Clin Invest 119:3830-8. 2009
    b>Growth hormone (GH) is a major metabolic regulator that functions by stimulating lipolysis, preventing protein catabolism, and decreasing insulin-dependent glucose disposal...
  52. ncbi Cause of sudden, unexpected death of Prader-Willi syndrome patients with or without growth hormone treatment
    T Nagai
    Department of Pediatrics, Dokkyo University School of Medicine Koshigaya Hospital, Saitama, Japan
    Am J Med Genet A 136:45-8. 2005
    ..Since growth hormone (GH) treatment was applied to PWS patients worldwide, several cases of death have been reported...
  53. ncbi Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1
    Derek LeRoith
    Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Nat Clin Pract Endocrinol Metab 3:302-10. 2007
    ..IGF1 is a major gene target of growth hormone and its product mediates many of the actions of growth hormone on growth and development; however, IGF1 has ..
  54. ncbi Small for gestational age: short stature and beyond
    Paul Saenger
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Endocr Rev 28:219-51. 2007
    ..Recent data, however, suggest that long-term treatment with GH does not increase the risk of type 2 diabetes mellitus and the metabolic syndrome in young adults born SGA...
  55. pmc Use of a prolactin-Cre/ROSA-YFP transgenic mouse provides no evidence for lactotroph transdifferentiation after weaning, or increase in lactotroph/somatotroph proportion in lactation
    Emma Castrique
    Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Bristol, UK
    J Endocrinol 205:49-60. 2010
    ..This, in combination with a modest and non-cell type-specific estrogen-induced increase in mitotic activity, could account for pregnancy-induced changes in overall pituitary size...
  56. ncbi A dominant-negative human growth hormone-releasing hormone (GHRH) receptor splice variant inhibits GHRH binding
    Allison T McElvaine
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Endocrinology 147:1884-94. 2006
    ..The results support an important role for alternative splicing in mediating the effects of G protein-coupled receptors in general, and suggest that the GHRH receptor can form multimers, which may be important to its signaling properties...
  57. ncbi Effect of growth hormone (GH) treatment on bone in postpubertal GH-deficient patients: a 2-year randomized, controlled, dose-ranging study
    Stephen M Shalet
    Department of Endocrinology, Christie Hospital NHS Trust, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 88:4124-9. 2003
    ..Although there was a by-gender dose effect on IGF-I concentration, the treatment effect on bone was obtained in both males and females with the adult GH dose regimen...
  58. ncbi Childhood growth hormone deficiency, bone density, structures and fractures: scrutinizing the evidence
    Wolfgang Hogler
    Department of Endocrinology and Diabetes, Birmingham Children s Hospital, Birmingham, UK
    Clin Endocrinol (Oxf) 72:281-9. 2010
    Childhood-onset growth hormone deficiency (GHD) is frequently perceived to cause low bone density, fractures and osteoporosis. This article critically reviews the evidence behind these perceptions...
  59. ncbi Effect of nutritional rehabilitation on circulating ghrelin and growth hormone levels in patients with anorexia nervosa
    Muneki Tanaka
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, Sakuragaoka 8 35 1, Kagoshima City 890 8520, Japan
    Regul Pept 122:163-8. 2004
    Circulating ghrelin and growth hormone (GH) are up-regulated in anorexia nervosa (AN) as a consequence of prolonged starvation...
  60. pmc Role of growth hormone in regulating lipolysis, proteolysis, and hepatic glucose production during fasting
    Alla A Sakharova
    Division of Metabolism, Endocrinology, and Diabetes, 3920 Taubman Center, University of Michigan Medical Center, Ann Arbor, MI 48109 5354, USA
    J Clin Endocrinol Metab 93:2755-9. 2008
    ..Fasting is associated with suppressed insulin and augmented GH secretion. The involvement of each mechanism in the regulation of fuel mobilization during fasting is unknown...
  61. ncbi Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function
    Raul M Luque
    Section of Endocrinology and Metabolism, Department of Medicine, University of Illinois at Chicago, Illinois, USA
    Endocrinology 147:2754-63. 2006
    ....
  62. ncbi Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes
    Jorg Kotzka
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich Heine University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Duesseldorf, Germany
    Atherosclerosis 213:156-65. 2010
    ..In the regulation of lipid content of cells and tissues the SREBPs play a dominant role as transcription factors...
  63. ncbi Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression
    Ying Wang
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Biol Chem 280:10955-63. 2005
    b>Growth hormone (GH) regulates insulin-like growth factor-I (IGF-I) gene expression through signal transducer and activator of transcription 5b (STAT5b) and STAT5a...
  64. ncbi Effects of gonadotrophins, growth hormone, and activin A on enzymatically isolated follicle growth, oocyte chromatin organization, and steroid secretion
    Safiriyu Idowu Ola
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Mol Reprod Dev 75:89-96. 2008
    ..We conclude that the present standard follicle culture system does not produce optimum proportion of developmentally competent oocytes...
  65. ncbi Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus
    Patricia Pennisi
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Betheda, MD 20892, USA
    Endocrinology 147:2619-30. 2006
    ..Also, these results suggest that a functional IGF-I receptor in skeletal muscle is required for IGF-I to improve insulin sensitivity in this mouse model of type 2 DM...
  66. ncbi The role of STAT proteins in growth hormone signaling
    J Herrington
    Department of Physiology, University of Michigan Medical School, Ann Arbor, Michigan, MI 48109 0622, USA
    Oncogene 19:2585-97. 2000
    b>Growth hormone (GH) has long been known to be the body's primary regulator of body growth and a regulator of metabolism, yet the mechanisms by which GH regulates the transcription of specific genes required for these processes are just ..
  67. ncbi Growth hormone, the insulin-like growth factor axis, insulin and cancer risk
    Peter E Clayton
    Manchester Academic Health Sciences Centre, University of Manchester, Paediatric Endocrinology, Royal Manchester Children s Hospital, Oxford Road, Manchester, UK
    Nat Rev Endocrinol 7:11-24. 2011
    b>Growth hormone (GH), insulin-like growth factor (IGF)-I and insulin have potent growth-promoting and anabolic actions. Their potential involvement in tumor promotion and progression has been of concern for several decades...
  68. ncbi Consensus statement on the standardization and evaluation of growth hormone and insulin-like growth factor assays
    David R Clemmons
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7170, USA
    Clin Chem 57:555-9. 2011
    b>Growth hormone (GH) and insulin-like growth factor I (IGF-I) measurements are widely used in the diagnosis of disorders of GH secretion, evaluation of children with short stature from multiple causes, management of disorders that lead to ..
  69. ncbi The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    Yukari Date
    Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Gastroenterology 123:1120-8. 2002
    ..Ghrelin, a peptide primarily produced in the stomach, stimulates both feeding and growth hormone (GH) secretion. How stomach-derived ghrelin exerts these central actions is still unknown...
  70. ncbi The rapid activation of protein synthesis by growth hormone requires signaling through mTOR
    Amanda A Hayashi
    Institute of Food Nutrition and Human Health, Massey University, and Metabolism and Microbial Genomics Section, AgResearch Limited, Palmerston North, New Zealand
    Am J Physiol Endocrinol Metab 292:E1647-55. 2007
    An important function of growth hormone (GH) is to promote cell and tissue growth, and a key component of these effects is the stimulation of protein synthesis...
  71. pmc Insulin-like growth factor 1 (IGF-1): a growth hormone
    Z Laron
    Endocrinology and Diabetes Research Unit, WHO Collaborating Center for the Study of Diabetes in Youth, Schneider Children s Medical Center, Tel Aviv University, 14 Kaplan Street, Petah Tikva 49202, Tel Aviv, Israel
    Mol Pathol 54:311-6. 2001
    To contribute to the debate about whether growth hormone (GH) and insulin-like growth factor 1 (IGF-1) act independently on the growth process.
  72. ncbi Genes that prolong life: relationships of growth hormone and growth to aging and life span
    A Bartke
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512, USA
    J Gerontol A Biol Sci Med Sci 56:B340-9. 2001
    Mutant mice with a combined deficiency of growth hormone (GH), prolactin, and thyrotropin, and knockout mice with GH resistance, live longer than their normal siblings...
  73. pmc Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes
    Wei Chen
    Department of Geriatrics, Hua Shan Hospital, Fudan University, Shanghai 200040, China
    J Biol Chem 286:34559-66. 2011
    Fibroblast growth factor (FGF) 21 and growth hormone (GH) are metabolic hormones that play important roles in regulating glucose and lipid metabolism...
  74. ncbi The endocrine regulation of aging by insulin-like signals
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 299:1346-51. 2003
    ..In mammals, the order in which the hormones act is unresolved because insulin, insulin-like growth factor-1, growth hormone, and thyroid hormones are interdependent...
  75. pmc Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism
    Myunggi Baik
    Laboratory of Genetics and Physiology, National Institutes of Health, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1229:29-37. 2011
    The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5)...
  76. ncbi Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration
    Yongzhi Cui
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892 0822, USA
    Hepatology 46:504-13. 2007
    b>Growth hormone controls many facets of a cell's biology through the transcription factors Stat5a and Stat5b (Stat5)...
  77. ncbi Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958-2003
    Zvi Laron
    Endocrinology and Diabetes Research Unit, Schneider Children s Medical Center, World Health Organization Collaborating Center for the Study of Diabetes in Youth, Tel Aviv University, Tel Aviv 49202, Israel
    J Clin Endocrinol Metab 89:1031-44. 2004
    ..This review presents the personal experience gained from the study follow-up and treatment of the 60 patients followed up for many years in the Israeli cohort...
  78. ncbi Adult height after long-term, continuous growth hormone (GH) treatment in short children born small for gestational age: results of a randomized, double-blind, dose-response GH trial
    Yvonne van Pareren
    Department of Pediatrics, Division of Endocrinology, Sophia Children s Hospital Erasmus Medical Center, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:3584-90. 2003
    ..In conclusion, long-term continuous GH treatment in short children born SGA without signs of persistent catch-up growth leads to a normalization of AH, even with a GH dose of 3 IU/m(2).d ( approximately 0.033 mg/kg.d)...
  79. pmc Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice
    Mahendra D Mavalli
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Invest 120:4007-20. 2010
    Skeletal muscle development, nutrient uptake, and nutrient utilization is largely coordinated by growth hormone (GH) and its downstream effectors, in particular, IGF-1...
  80. ncbi Adult growth hormone treatment reduces hypertension and obesity induced by an adverse prenatal environment
    M H Vickers
    The Liggins Institute for Medical Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Endocrinol 175:615-23. 2002
    ..Our data demonstrated that GH treatment reduces hypertension and improves cardiovascular function in animals exposed to adverse environmental conditions during fetal or postnatal life...
  81. pmc Regulation of muscle mass by growth hormone and IGF-I
    C P Velloso
    King s College London, Division of Applied Biomedical Research, London, UK
    Br J Pharmacol 154:557-68. 2008
    b>Growth hormone (GH) is widely used as a performance-enhancing drug. One of its best-characterized effects is increasing levels of circulating insulin-like growth factor I (IGF-I), which is primarily of hepatic origin...
  82. ncbi In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver
    Oscar M Vidal
    Department of Molecular Medicine and Surgery, Karolinska Institutet 17176 Stockholm, Sweden
    Mol Endocrinol 21:293-311. 2007
    ..In summary, we demonstrate the power of combining transcript profiling with phylogenetic sequence analysis to define novel regulatory paradigms...
  83. ncbi Growth hormone and insulin-like growth factors in fish: where we are and where to go
    Manfred Reinecke
    Division of Neuroendocrinology, Institute of Anatomy, University of Zurich, CH 8057 Zurich, Switzerland
    Gen Comp Endocrinol 142:20-4. 2005
    ..This communication summarizes viewpoints, discussion, perspectives, and questions, put forward at a workshop on "Growth hormone and insulin-like growth factors in fish" held on September 7th, 2004, at the 5th International Symposium on ..
  84. ncbi Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons
    Dana I Briggs
    Department of Physiology, Monash University, Building 13F, Clayton Campus, Wellington Road, Clayton, Victoria 3183, Australia
    Endocrinology 151:4745-55. 2010
    ..Ghrelin resistance in DIO is not confined to the NPY/AgRP neurons, because ghrelin did not stimulate growth hormone secretion in DIO mice...
  85. ncbi Pasireotide (SOM230): development, mechanism of action and potential applications
    Herbert A Schmid
    Novartis Institutes for BioMedical Research, Oncology Research, Novartis Pharma AG, Basel, Switzerland
    Mol Cell Endocrinol 286:69-74. 2008
    ....
  86. ncbi The influence of gender on the short and long-term effects of growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults: a 5-year study
    W M Drake
    Department of Endocrinology, St Bartholomew's Hospital, London UK
    Clin Endocrinol (Oxf) 54:525-32. 2001
    ..of this study were to investigate the effects of GH replacement therapy in hypopituitary adults with growth hormone deficiency (GHD) on activation of bone remodelling during dose titration and on BMD over a median of 58 months ..
  87. ncbi A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone
    Christine Dos Santos
    U561 INSERM, Saint Vincent de Paul Hospital, Paris V University, 82 avenue Denfert Rochereau, 75014 Paris, France
    Nat Genet 36:720-4. 2004
    b>Growth hormone is used to increase height in short children who are not deficient in growth hormone, but its efficacy varies largely across individuals. The genetic factors responsible for this variation are entirely unknown...
  88. ncbi Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance
    Juan Pablo Del Rincon
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Diabetes 56:1638-46. 2007
    ..Adipose tissue plays a critical role in the antagonistic effects of growth hormone (GH) on insulin actions on carbohydrate and lipid metabolism through changes in gene transcription...
  89. pmc Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice
    Yingjie Wu
    Division of Endocrinology, Diabetes, and Bone Disease, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Endocrinology 150:4395-403. 2009
    ..Furthermore, we show that tissue IGF-I is necessary for the development of the female reproductive system and cannot be compensated by elevated levels of serum IGF-I...
  90. ncbi Transsphenoidal surgery and adjuvant gamma knife treatment for growth hormone-secreting pituitary adenoma
    H Ikeda
    Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan
    J Neurosurg 95:285-91. 2001
    The results of combined transsphenoidal surgery and adjuvant gamma knife surgery (GKS) for growth hormone (GH)-secreting adenoma were investigated using biochemical cure criteria for surgery and biological cure criteria for adjuvant GKS.
  91. pmc Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice
    Shoshana Yakar
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda Maryland 20892 1758, USA
    J Clin Invest 113:96-105. 2004
    ..LID) mice have a 75% reduction in circulating IGF-1 levels and, as a result, a fourfold increase in growth hormone (GH) secretion. To block GH action, LID mice were crossed with GH antagonist (GHa) transgenic mice...
  92. ncbi Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity
    S Yakar
    Cellular Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Diabetes 50:1110-8. 2001
    ..The LID mice show a marked reduction (approximately 75%) in circulating IGF-I and elevated growth hormone (GH) levels. Interestingly, LID mice show a fourfold increase in serum insulin levels (2.2 vs. 0...
  93. ncbi Mental and motor development before and during growth hormone treatment in infants and toddlers with Prader-Willi syndrome
    D A M Festen
    Dutch Growth Foundation, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 68:919-25. 2008
    ..GH treatment improves growth velocity and body composition. Research on the effects of GH on psychomotor development in infants with PWS is limited...
  94. ncbi The regulation of fatty acid synthase by STAT5A
    Jessica C Hogan
    Louisiana State University, Department of Biological Sciences, 202 Life Sciences Bldg, Baton Rouge, LA 70803, USA
    Diabetes 54:1968-75. 2005
    b>Growth hormone (GH) diminishes adipose tissue mass in vivo and decreases expression and activity of fatty acid synthase (FAS) in adipocytes...
  95. ncbi The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins
    S F Ahmed
    Developmental Endocrinology Research Group, Division of Developmental Medicine, Department of Child Health, Royal Hospital for Sick Children, University of Glasgow, Yorkhill, Glasgow G3 8SJ, UK
    J Endocrinol 206:249-59. 2010
    ..Chronic inflammation is associated with altered growth and skeletal development, and it is possible that SOCS proteins may have an important role to play in mediating these effects...
  96. ncbi GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism
    Johanna L Barclay
    Institute for Molecular Bioscience, University of Queensland, Woolloongabba 4102, Australia
    Endocrinology 152:181-92. 2011
    ..These results raise the possibility of low-dose GH treatment for nonalcoholic fatty liver disease...
  97. ncbi Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents
    Katsuya Dezaki
    Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Kawachi, Tochigi, Japan
    Diabetes 53:3142-51. 2004
    Ghrelin, isolated from the human and rat stomach, is the endogenous ligand for the growth hormone (GH) secretagogue receptor, which is expressed in a variety of tissues, including the pancreatic islets...
  98. ncbi Influences of the environment on the endocrine and paracrine fish growth hormone-insulin-like growth factor-I system
    M Reinecke
    Division of Neuroendocrinology, Institute of Anatomy, University of Zurich, Winterthurerstr 190, 8057 Zurich, Switzerland
    J Fish Biol 76:1233-54. 2010
    ..The primary stimulus for synthesis and release of IGF-I is growth hormone (GH) from the anterior pituitary. Thus, in analogy to mammals, it is usual to speak of a fish 'GH-IGF-I axis'...
  99. pmc Domestication and growth hormone transgenesis cause similar changes in gene expression in coho salmon (Oncorhynchus kisutch)
    Robert H Devlin
    Fisheries and Oceans Canada, 4160 Marine Drive, West Vancouver, BC, Canada V7V 1N6
    Proc Natl Acad Sci U S A 106:3047-52. 2009
    ..More recently, transgenesis of growth factor genes [primarily growth hormone (GH)] has also been explored as a rapid approach to accelerating performance of agricultural species...
  100. ncbi Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone
    K L Williams
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Gastroenterology 120:925-37. 2001
    b>Growth hormone (GH) is used as therapy for inflammatory bowel disease (IBD), but the specific effects on intestine are unknown...
  101. ncbi Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    P Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:1738-45. 2001
    ..In conclusion, this study provides the first demonstration of specific GHS binding sites, other than GHS-R1, in breast cancer. These receptors probably mediate growth inhibitory effects on breast carcinoma cells in vitro...

Research Grants71

  1. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    ..acute lymphoblastic leukemia (manuscript under review), and a second study examining skeletal complications of growth hormone therapy in cancer survivors after radiation compared to children treated with growth hormone for idiopathic ..
  2. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..However, definitive diagnosis of growth hormone deficiency (GHD) and secondary adrenal insufficiency (sAI) typically requires the use of provocative testing...
  3. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
    ..First, the co-localization of the ghrelin receptor [growth hormone secretagogue receptor-1a (GHS-R1a)] mRNA with the SNS outflow to BAT and to WAT will be tested using the ..
  4. The Somatotropic Axis and Health Aging: A Search for Mechanisms
    Andrzej Bartke; Fiscal Year: 2013
    ..The long-term goal of the proposed research is to identify mechanisms responsible for the effects of growth hormone (GH) signaling on aging and longevity in mammals...
  5. Growth Hormone Regulation of SH2B1
    Christin Carter-Su; Fiscal Year: 2013
    ..to that of SH2B1-/- mice) is consistent with SH2B1 being a signaling molecule for multiple ligands, including growth hormone (GH), leptin, and insulin...
  6. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..bone density and bone marrow composition, including adrenal and gonadal steroids, insulin-like growth factors, growth hormone, and ghrelin, adiponectin, and leptin...
  7. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Growth hormone (GH) is produced by somatotropes of the anterior pituitary gland and is released into the general circulation where it stimulates the production of insulin-like growth factor I (IGF-I) ..
  8. IGF-1, bone turnover and response to teriparatide in premenopausal women with IOP
    Adi Cohen; Fiscal Year: 2013
    ..formation that is related to deficient insulin-like growth factor 1 (IGF-1), a hormone produced in response to growth hormone (GH) that is anabolic to the bone-forming osteoblast...
  9. Epigenetic Regulation Of Sex-dependent Liver Cancer
    Arlin B Rogers; Fiscal Year: 2012
    ..Liver masculinization is enacted by pulsatile growth hormone from the pituitary...
  10. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ..Multiple factors cause the wasting including resistance to or deficiency of anabolic hormones such as growth hormone (GH) and insulin-like growth factor 1 (IGF-1)...
  11. Developmental Origins of Phenotypic Characteristics that Predict Longevity
    Andrzej Bartke; Fiscal Year: 2012
    ..To determine the effects of treating long-lived hypopituitary Prop1df (Ames dwarf) mice with growth hormone (GH) or with a combination of hormones starting at one week, two weeks or two months of age on oxygen ..
  12. The Role of Estradiol and Sex in the Effects of Ghrelin on Meal Patterns and Fos-
    PETER BUTERA; Fiscal Year: 2009
    ..a peptide hormone synthesized principally in the stomach that binds to a receptor in the brain and regulates growth hormone secretion...
  13. A PANHYPOPITUITARY MOUSE MUTATION
    Sally A Camper; Fiscal Year: 2013
    ..Prop1 deficiency causes pituitary hypoplasia and lack three cell types, including those that produce growth hormone. Gain of function alleles cause transient hypogonadism, delayed puberty, and increased risk of pituitary ..
  14. Cell Specific Expression in the Pituitary Gland
    Sally A Camper; Fiscal Year: 2013
    ..Treatment involves hormone replacement therapy, which can involve daily injections of recombinant growth hormone at great expense per patient...
  15. Transferrin Conjugates for Oral Protein Drug Delivery
    Wei Chiang Shen; Fiscal Year: 2013
    ..e., granulocyte colony-stimulating factor (G-CSF), human growth hormone (hGH) and proinsulin (ProINS)...
  16. The regulation and activation of STATs in adipocytes
    Jacqueline M Stephens; Fiscal Year: 2013
    ..b>Growth hormone, a potent inducer of STAT 5 proteins is well known to have effects that are lipolytic, anti-lipogenic and ..
  17. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..gene (Lepr) will be created by crossing founders carrying the Cre- recombinase transgene driven by the rat growth hormone promoter (rGHp-Cre) or the rat luteinizing hormone- 2 promoter (rLH2p-GFP-Cre) with mice carrying the Ob-R ..
  18. Growth Hormone Regulation of SH2-B1
    Christin Carter Su; Fiscal Year: 2009
    Identification of JAK family tyrosine kinases as receptor-associated signaling molecules for growth hormone (GH) receptors (GHR) and the many other members of the cytokine receptor superfamily was a major step forward in our understanding ..
  19. New Approaches to the Evaluation and Treatment of Acromegaly
    Pamela U Freda; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Acromegaly, a rare disease due to a growth hormone producing pituitary tumor, is associated with increased morbidity and mortality...
  20. NOVEL APPROACHES FOR REGULATION OF IGF-1 LEVELS THROUGHOUT THE LIFESPAN
    William Edmund Sonntag; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Previous studies have provided compelling evidence that the Growth Hormone (GH)-IGF-1 axis is a conserved pathway important for determination of both healthspan and lifespan in diverse organisms...
  21. Developmental Regulation of Drug Processing Genes
    Xiao bo Zhong; Fiscal Year: 2013
    ..essential for normal development, including hepatocyte nuclear factor 11 (HNF11), farnesoid X receptor (FXR), growth hormone (GH) signaling, and epigenetic influences...
  22. Identification of Central Targets of Ghrelin
    Jeffrey M Zigman; Fiscal Year: 2010
    ..Ghrelin, the endogenous ligand for the growth hormone secretagogue receptor (GHSR, ghrelin receptor) has emerged as one of these potentially key metabolic signals...
  23. Impact of Exercise on Body Composition in Premature Infants: New Approaches
    Dan M Cooper; Fiscal Year: 2013
    ..activity intervention on the balance between circulating anabolic mediators (insulin-like growth factor-I and growth hormone binding protein) and inflammation-associated cytokines (interleukin-6, and interleukin-1 receptor antagonist), ..
  24. Growth and Carcinogenic Potential in the Postnatal Mammary Gland
    Demetri D Spyropoulos; Fiscal Year: 2010
    ..Paracrine estrogen receptor (ER1) stimulation elevates growth hormone-induced production and release of insulin-like growth factor 1 (IGF-I) and thereby induces an epithelial ..
  25. THE TEMPORAL AND SPATIAL REGULATION OF BONE ACQUISITION BY SERUM IGF-1
    Shoshana Yakar; Fiscal Year: 2012
    ..model: 1- IGF-I deficiency starts from birth;and 2- there is a profound and perpetual secondary increase in growth hormone. Thus, the developmental sequences and the anatomical changes in the skeleton of the growing and adult animal ..
  26. Epigenetic Changes with Age in Hematopoietic Stem Cells
    Gretchen J Darlington; Fiscal Year: 2010
    ..role of the IGF1 pathway in chromatin modification, we will examine the HSC from a long lived mouse model, the growth hormone releasing hormone receptor mutant, the Little mouse...
  27. Regulated Retrotransposon Elements in Neuroendocrine System
    Janusz Puc; Fiscal Year: 2009
    ..Preliminary data indicates that an insulator element exists within a distal regulatory region of the mouse growth hormone gene locus that may act to establish independent domains of differential chromatin modifications...
  28. The geriatric surgical patient: stress, anesthetics, and functional outcomes
    Stacie Deiner; Fiscal Year: 2012
    ..response as evidenced by serum cortisol, lower plasma levels of norepinephrine (NE), epinephrine (E), and growth hormone (GH), and lesser heart rate variability (HRV)...
  29. Genetic Epidemiology of Osteosarcoma
    Logan G Spector; Fiscal Year: 2010
    ..will employ the case-parent triad design to study main effects of genes in the insulin-like growth factor/growth hormone axis and estrogen metabolism pathways, which relate to bone growth, and two genes involved in DNA integrity (..
  30. Interrelationship between the GH-axis and metabolism
    Rhonda D Kineman; Fiscal Year: 2013
    ..In that the liver is a major target of growth hormone (GH), coupled with the fact that developmental- and disease-associated changes in GH secretion/action are ..
  31. CELL BIOLOGY OF BIOACTIVE PEPTIDE SECRETION
    Richard E Mains; Fiscal Year: 2013
    ..Using lentiviruses or mating with mice in which expression of Cre recombinase is driven by the POMC or growth hormone promoter, Kalirin expression in corticotropes or somatotropes will be eliminated...
  32. Structure and Regulation of Ghrelin in Obesity
    Jonathan Q Purnell; Fiscal Year: 2010
    ..Ghrelin is a recently described gut hormone originally discovered as an endogenous ligand for the growth hormone secretagogue receptor...
  33. Peptidergic Control of Appetitive Ingestive Behaviors
    TIMOTHY JON BARTNESS; Fiscal Year: 2013
    ..Ghrelin stimulates neurons bearing ghrelin receptors [growth hormone secretagogue (GHSR)]...
  34. GH Receptor Proteolysis and Shedding
    Stuart J Frank; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Growth hormone (GH) is a pituitary-derived peptide hormone with potent somatogenic and metabolic actions...
  35. Growth Hormone, Mitochondria, and Cardio-metabolic Complications of Obesity
    Hideo Makimura; Fiscal Year: 2013
    ..b>Growth hormone (GH), a pituitary gland derived anabolic hormone which stimulates lipolysis, is reduced in association with ..
  36. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina V Zhdanova; Fiscal Year: 2013
    ..and those encoding for the melatonin receptors, dopamine transporter, cyclin-dependent kinases, cyclin A and growth hormone will be evaluated throughout development and maturation...
  37. GROWTH HORMONE RECEPTORS AND ACTIONS
    Christin Carter Su; Fiscal Year: 2010
    One of the most exciting advances in understanding the molecular actions of growth hormone (GH) was the identification of the tyrosine (Tyr) kinase JAK2 as a receptor-associated signaling molecule for the GH receptor (GHR)...
  38. Growth Hormone Receptor Dimerization &Disulfide Linkage
    Stuart J Frank; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Growth hormone (GH), derived largely from the anterior pituitary, regulates postnatal growth and metabolism in vertebrates in an endocrine fashion...
  39. Long lasting ghrelin derivatives for the treatment of cancer cachexia
    TARIK SOLIMAN; Fiscal Year: 2013
    ..Ghrelin also stimulates the release of growth hormone, resulting in increased muscle mass, and ghrelin is reported to have anti-inflammatory activity...
  40. Regulation of Sex Differences in Liver Metabolism
    David J Waxman; Fiscal Year: 2013
    ..This application focuses on the genomic and epigenomic actions of growth hormone (GH), a pituitary polypeptide hormone and major regulator of liver metabolic functions, in particular those ..
  41. Regulation of Age-Related Inflammation in Septic Shock
    Ping Wang; Fiscal Year: 2010
    ..A low dose of growth hormone (GH) upregulates ghrelin receptor in aged rats, suggesting that GH is a ghrelinsensitizing agent...
  42. A Novel Compound for Alcoholism Treatment: a Translational Strategy
    Lorenzo Leggio; Fiscal Year: 2013
    ..It is an endogenous ligand for the growth hormone secretagogue receptor (GHSR1a)...
  43. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    NIR J BARZILAI; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Growth hormone/IGF-1 axis is central in aging and longevity, and controversial and it's translation to treatment...
  44. CNS Pathways Regulating Ghrelin Effects on Body Weight
    Joel K Elmquist; Fiscal Year: 2012
    ..past grant period, we sought to delineate the neural substrates through which ghrelin and its receptor, the growth hormone secretagouge receptor (GHSR;ghrelin receptor) selectively regulate food intake and body weight...
  45. Overcoming Disparities in Growth Evaluations
    Adda Grimberg; Fiscal Year: 2012
    ..In 2003, the Food and Drug Administration approved growth hormone (GH) treatment for idiopathic short stature, the first indication that emphasizes height rather than ..
  46. Augmenting Pulsatile Growth Hormone: Metabolic Effects in HIV-Infection
    TAKARA LEAH STANLEY; Fiscal Year: 2013
    ..novel strategy to decrease abdominal fat and reduce metabolic risk in HIV- infection by augmenting endogenous growth hormone (GH) secretion through the use of growth hormone releasing hormone (GHRH1-44)...
  47. Metabolic Syndrome Following Transplant for Leukemia
    KEVIN S BAKER; Fiscal Year: 2010
    ..of age with longer follow-up after HCT, b) specific HCT treatment exposures will be associated with growth hormone deficiency and higher degrees of IR, c) allogeneic HCT will be associated with higher levels of inflammatory ..
  48. Stress and Memory Formation Across the Female Lifespan
    Tracey Shors; Fiscal Year: 2009
    ..are designed to explore a potential relationship between sex differences in learning and the expression of growth hormone (GH) in the hippocampus, a gene that is preferentially induced by learning (Donahue et al., 2002)...
  49. Ghrelin Regulation: Implications for Understanding Obesity
    Michael O Thorner; Fiscal Year: 2012
    ..provided by applicant): Ghrelin is a gut-derived acylated peptide hormone that stimulates secretion of growth hormone and ACTH, as well as orexigenesis...
  50. Transgenic Approaches to Evaluate IGF-I Role in Peak BMD
    Subburaman Mohan; Fiscal Year: 2013
    ..To this end, our studies involving genetic mouse models that are deficient in thyroid hormone (TH) and/or growth hormone (GH) action have provided unequivocal evidence that there is an important window of time, prior to puberty, ..
  51. Suppression of tadpole limbs: a model for organ size regulation
    RICHARD ELINSON; Fiscal Year: 2009
    Body size can be altered by pituitary growth hormone, with the largest and smallest nonobese humans varying by about 10-fold in body mass...
  52. The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes.
    Jenny Tong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ghrelin is a gut hormone that stimulates growth hormone secretion, promotes food intake and adiposity...
  53. pH Sensitive Complex Hydrogels for Protein Drug Release
    Nicholas A Peppas; Fiscal Year: 2013
    ..designated as P (MAA-g-EG), have shown extreme promise as oral delivery vehicles for insulin, calcitonin, and growth hormone. Prior studies have established that these systems are promising candidates for oral delivery of insulin...
  54. Production &Crystallization of Membrane Protein for 3D Structure
    Lawrence J Delucas; Fiscal Year: 2013
    ..protein, CFTR), two GPCRs (chemokine receptor-1, CCR1 and sphingosine- 1 phosphate receptor, S1P) and growth hormone receptor, GHR...
  55. Opposing Effects of Chronic Stress on Amygdala and Hippocampus
    Ki Ann Goosens; Fiscal Year: 2013
    ..Third, we will determine the contribution of growth hormone, a gene that is oppositely regulated in the hippocampus and amygdala after chronic stress, to stress- induced ..
  56. The role of central IGF- 1 feedback in the regulation of growth and metabolism
    CHRISTOPHER JOSEPH ROMERO; Fiscal Year: 2013
    ..provided by applicant): The role of insulin-like growth factor 1 (IGF-1) in the negative regulation of growth hormone (GH) expression and release is demonstrated by in vitro and in vivo models;however, the targets and mechanisms ..
  57. Mechanism and Prevention of Female Stress Urinary Incontinence
    Tom F Lue; Fiscal Year: 2013
    ..In an attempt to develop preventive measures for SUI, we noted that early administration of growth hormone significantly reduced the incontinence rate in our animal model...
  58. Natural history of bone disease and the impact of growth hormone treatment in MPS
    LYNDA ELIZABETH POLGREEN; Fiscal Year: 2013
    ..Polgreen will pursue the following specific aims: 1) To determine the impact of 24 months of recombinant human growth hormone therapy versus no therapy on bone development and growth in 34 children with MPS I, II, and VI and short ..
  59. Cross-talk between growth hormone and inflammation pathways in kidney damage
    Karen T Coschigano; Fiscal Year: 2010
    ..We have been studying kidney damage in mouse models with different levels of growth hormone (GH) signaling ranging from over-expression to complete lack of GH signaling...
  60. Growth hormone signaling and lipid metabolism in fatty liver disease
    ETHAN WEISS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The effects of growth hormone (GH) on lipid metabolism are varied. Among these, GH mobilizes energy from fat cells in the form of plasma free fatty acids...
  61. Determinants of breast tissue composition in young women
    Johanna M Rommens; Fiscal Year: 2013
    ..We also found that blood levels of growth hormone and sex hormone binding globulin in all subjects were associated with breast water content...
  62. Mechanisms of Growth Hormone Resistance in Sepsis
    Robert N Cooney; Fiscal Year: 2010
    ..An improved understanding of how cytokines and growth factors regulate protein catabolism is important to provide better care for these patients. ..
  63. Long-acting Growth Hormone for Treating HIV-Associated Adipose Redistribution Syn
    George Cox; Fiscal Year: 2009
    ..BBT-031 that has a significantly increased circulating half-life and superior efficacy in animal models of growth hormone deficiency compared to GH...
  64. PEDIATRIC NEPHROLOGY TRAINING GRANT
    Harry Koo; Fiscal Year: 2003
    ..J. Chan, Scheinman; growth failure and growth hormone secretion and female reproductive functions in uremia (Drs. Krieg, J...
  65. REGULATION OF SKELETAL GROWTH IN RENAL FAILURE
    CHERYL SANCHEZ; Fiscal Year: 2003
    ..Calcitriol and recombinant human growth hormone are widely utilized to improve liner growth in children, but large intermittent doses of calcitriol have been ..
  66. ENDOCHONDRAL BONE FORMATION IN RENAL FAILURE
    ISIDRO SALUSKY; Fiscal Year: 1999
    ..Growth retardation occurs invariably in children with chronic renal failure; renal osteodystrophy and growth hormone resistance are considered to be major factors contributing to impaired skeletal growth...
  67. TNF ALPHA REG OF THE GROWTH HORMONE/IGF-1 AXIS WITH AGE
    William Sonntag; Fiscal Year: 2000
    ..of studies clearly suggest that a general decline in signal transduction and, specifically, a decline in growth hormone signal transduction, are critical aspects of biological aging but the specific etiology of these changes are ..
  68. Tyrosine Phosphyorylation and Growth Hormone Signaling
    STUART FRANK; Fiscal Year: 2005
    b>Growth hormone (GH) and prolactin (PRL) interact with GH and prolactin receptors (GHR; PRLR), both cytokine receptors, causing activation of the GHR- and PRLR-associated tyrosine kinase, JAK2, and the STATS and ERK pathways...
  69. HPA Axis in Depression and Anxiety
    Elizabeth Young; Fiscal Year: 2005
    ..Panic Disorder, is accompanied by abnormalities of the central noradrenergic system, as reflected by a blunted growth hormone response to clonidine...
  70. Growth Hormone, IGF-1 and Age-related Pathogenesis
    William Sonntag; Fiscal Year: 2003
    ..In this application, we propose that growth hormone and IGF- I have the potential to regulate age-related pathogenesis through their well-known actions on cell ..
  71. Growth Hormone & IGF-1 in CNS and Cerebrovascular Aging
    William Edmund Sonntag; Fiscal Year: 2010
    ..provided by applicant): This application is a competing continuation of a Program Project entitled 'Growth Hormone &IGF-1 in CNS and Cerebrovascular Aging'...