vasopressins

Summary

Summary: Octapeptide antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (chemical composition varies with species). They control water metabolism and balance by regulating LUNG; GILLS; KIDNEY; etc., and water loss, and also contract smooth muscle. They may also be NEUROTRANSMITTERS. Also included are synthetic vasopressin derivatives. Vasopressins are used pharmacologically as renal agents, vasoconstrictor agents, and hemostatics.

Top Publications

  1. ncbi Sniffing neuropeptides: a transnasal approach to the human brain
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Neurosci 5:514-6. 2002
  2. ncbi Dendritic peptide release and peptide-dependent behaviours
    Mike Ludwig
    Laboratory of Neuroendocrinology, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Nat Rev Neurosci 7:126-36. 2006
  3. ncbi Treatment of uncontrolled hemorrhagic shock after liver trauma: fatal effects of fluid resuscitation versus improved outcome after vasopressin
    Claus Raedler
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anesth Analg 98:1759-66, table of contents. 2004
  4. ncbi Population dynamics in vasopressin cells
    Gareth Leng
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
    Neuroendocrinology 88:160-72. 2008
  5. pmc Vasopressin: behavioral roles of an "original" neuropeptide
    Heather K Caldwell
    Section on Neural Gene Expression, NIMH, NIH, DHHS, Bethesda, MD 20892, United States
    Prog Neurobiol 84:1-24. 2008
  6. ncbi Neuroendocrine control of body fluid metabolism
    Jose Antunes-Rodrigues
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Physiol Rev 84:169-208. 2004
  7. pmc Modulation/physiology of calcium channel sub-types in neurosecretory terminals
    Jose R Lemos
    Department of Microbiology and Physiological Systems and Program in Neuroscience, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell Calcium 51:284-92. 2012
  8. ncbi Hyponatremia and inflammation: the emerging role of interleukin-6 in osmoregulation
    Reinout M Swart
    Department of Internal Medicine Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nephron Physiol 118:45-51. 2011
  9. ncbi Protein-enriched diet increases water absorption via the aquaporin-2 water channels in healthy humans
    Thomas Guldager Lauridsen
    Department of Medicine, Department of Medical Research, Regional Hospital Holstebro, Lagaardvej 12, Holstebro, Denmark
    Nephrol Dial Transplant 25:2502-10. 2010
  10. ncbi Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar States
    Sandrina Balanescu
    Clinic of Internal Medicine, Hospital Center, Vogelsang 84, CH 2501 Biel Bienne, Switzerland
    J Clin Endocrinol Metab 96:1046-52. 2011

Detail Information

Publications318 found, 100 shown here

  1. ncbi Sniffing neuropeptides: a transnasal approach to the human brain
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Neurosci 5:514-6. 2002
  2. ncbi Dendritic peptide release and peptide-dependent behaviours
    Mike Ludwig
    Laboratory of Neuroendocrinology, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Nat Rev Neurosci 7:126-36. 2006
    ....
  3. ncbi Treatment of uncontrolled hemorrhagic shock after liver trauma: fatal effects of fluid resuscitation versus improved outcome after vasopressin
    Claus Raedler
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anesth Analg 98:1759-66, table of contents. 2004
    ..01). We conclude that vasopressin, but not saline placebo or fluid resuscitation, significantly improves short-term survival during uncontrolled hemorrhagic shock...
  4. ncbi Population dynamics in vasopressin cells
    Gareth Leng
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
    Neuroendocrinology 88:160-72. 2008
    ..Here we explore the mechanisms that enable vasopressin cells to fulfill this function, and consider how coordination between the cells might distribute the secretory load across the population of vasopressin cells...
  5. pmc Vasopressin: behavioral roles of an "original" neuropeptide
    Heather K Caldwell
    Section on Neural Gene Expression, NIMH, NIH, DHHS, Bethesda, MD 20892, United States
    Prog Neurobiol 84:1-24. 2008
    ..In this review, we concentrate on the scientific progress that has been made in understanding the role of Avp in regulating these and other behaviors across species. We also discuss the implications for human behavior...
  6. ncbi Neuroendocrine control of body fluid metabolism
    Jose Antunes-Rodrigues
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Physiol Rev 84:169-208. 2004
    ..This review emphasizes the role played by brain ANP and its interaction with neurohypophysial hormones in the control of body fluid homeostasis...
  7. pmc Modulation/physiology of calcium channel sub-types in neurosecretory terminals
    Jose R Lemos
    Department of Microbiology and Physiological Systems and Program in Neuroscience, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell Calcium 51:284-92. 2012
    ..We conclude by proposing a model that can explain how purinergic and/or opioid feedback modulation during bursts can mediate differences in the control of neurohypophysial AVP vs. OT release...
  8. ncbi Hyponatremia and inflammation: the emerging role of interleukin-6 in osmoregulation
    Reinout M Swart
    Department of Internal Medicine Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nephron Physiol 118:45-51. 2011
    ....
  9. ncbi Protein-enriched diet increases water absorption via the aquaporin-2 water channels in healthy humans
    Thomas Guldager Lauridsen
    Department of Medicine, Department of Medical Research, Regional Hospital Holstebro, Lagaardvej 12, Holstebro, Denmark
    Nephrol Dial Transplant 25:2502-10. 2010
    ....
  10. ncbi Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar States
    Sandrina Balanescu
    Clinic of Internal Medicine, Hospital Center, Vogelsang 84, CH 2501 Biel Bienne, Switzerland
    J Clin Endocrinol Metab 96:1046-52. 2011
    ..However, it is unknown to date how circulating copeptin and vasopressin levels correlate at different plasma osmolalites...
  11. ncbi Vasopressin, but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs
    Karl H Stadlbauer
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Anesthesiology 98:699-704. 2003
    ..The authors compared the effects of vasopressin fluid resuscitation on survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs...
  12. ncbi Toward understanding how early-life social experiences alter oxytocin- and vasopressin-regulated social behaviors
    Alexa H Veenema
    Neurobiology of Social Behavior Laboratory, Department of Psychology, Boston College, 140 Commonwealth Avenue, McGuinn 522, Chestnut Hill, MA 02467, USA
    Horm Behav 61:304-12. 2012
    ..This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior...
  13. ncbi Mechanisms of rhythmogenesis: insights from hypothalamic vasopressin neurons
    Colin H Brown
    Centre for Neuroendocrinology and Department of Physiology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand
    Trends Neurosci 29:108-15. 2006
    ..Many other neurons across the CNS release neurotransmitters from their dendrites; therefore, vasopressin cells provide an insight into the potential mechanisms that support neuronal activity patterning across the CNS...
  14. pmc The involvement of voltage-operated calcium channels in somato-dendritic oxytocin release
    Vicky A Tobin
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e25366. 2011
    ..These results suggest that the expression, location or availability of N-type Ca(2+) channels is altered when required for high rates of somato-dendritic peptide release...
  15. ncbi Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala
    Daniel Huber
    Department of Cellular Biology and Morphology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland
    Science 308:245-8. 2005
    ..Through this network, the expression and endogenous activation of vasopressin and oxytocin receptors may regulate the autonomic expression of fear...
  16. ncbi The vasopressin system--from antidiuresis to psychopathology
    Elisabeth Frank
    Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Eur J Pharmacol 583:226-42. 2008
    ..The capability of both responding to stressful stimuli and mediating genetic polymorphisms makes the vasopressin system a key mediator for converging (i.e., environmentally and genetically driven) behavioral regulation...
  17. pmc Neurotransmitters and peptides: whispered secrets and public announcements
    Gareth Leng
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    J Physiol 586:5625-32. 2008
    ..However, very large amounts of peptide are released by these infrequent events, consistent with their likely role as neurohormonal messengers...
  18. ncbi Successful resuscitation of a traumatic cardiac arrest victim in hemorrhagic shock with vasopressin: a case report and brief review of the literature
    Thorsten Haas
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    J Trauma 57:177-9. 2004
  19. ncbi Brain cell volume regulation in hyponatremia: role of sex, age, vasopressin, and hypoxia
    Juan Carlos Ayus
    Renal Consultants of Houston, 2412 Westgate Street, Houston, TX 77019, USA
    Am J Physiol Renal Physiol 295:F619-24. 2008
    ..The hypoxemia further impairs brain adaptation. Hyponatremic encephalopathy leads to brain damage when brain adaptation is impaired and is a consequence of both cerebral hypoxia and peptide hormones...
  20. ncbi Morphological and electrophysiological classification of hypothalamic supraoptic neurons
    W E Armstrong
    Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163, USA
    Prog Neurobiol 47:291-339. 1995
    ..The membrane properties of OT and VP neurons are generally similar in vitro, but the range of tests has not been extensive. The depolarizing afterpotential is more often exhibited by, but is not exclusive to, VP neurons...
  21. pmc Bench-to-bedside review: Vasopressin in the management of septic shock
    James A Russell
    Critical Care Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Crit Care 15:226. 2011
    ..The interaction of vasopressin infusion and corticosteroid treatment in septic shock requires further study...
  22. ncbi Vasopressin compared with norepinephrine augments the decline of plasma cytokine levels in septic shock
    James A Russell
    James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 188:356-64. 2013
    ..Changes in plasma cytokine levels may predict mortality, and therapies (vasopressin versus norepinephrine) could change plasma cytokine levels in early septic shock...
  23. ncbi Employing vasopressin as an adjunct vasopressor in uncontrolled traumatic hemorrhagic shock. Three cases and a brief analysis of the literature
    A C Krismer
    Department of Anesthesiology and Critical Care Medicine, Medical University, Innsbruck, Austria
    Anaesthesist 54:220-4. 2005
    ..The patient underwent multiple surgical procedures, developed multi-organ failure, but was finally discharged from the critical care unit without neurological damage...
  24. ncbi Loss of calcineurin Aalpha results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus
    Jennifer L Gooch
    Department of Medicine Nephrology, Emory University, Atlanta, GA 30322, USA
    J Cell Sci 119:2468-76. 2006
    ..These experiments demonstrate that, CnAalpha is required for normal intracellular trafficking of AQP2 and loss of calcineurin protein or activity disrupts AQP2 function...
  25. ncbi Evidence for suprachiasmatic vasopressin neurones innervating kisspeptin neurones in the rostral periventricular area of the mouse brain: regulation by oestrogen
    B Vida
    Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    J Neuroendocrinol 22:1032-9. 2010
    ..Altogether, our results are consistent with the hypothesis that KP neurones located in the mouse AVPV/PeN receive circadian information from the SCN via a vasopressinergic monosynaptic pathway, which is enhanced by oestrogen...
  26. ncbi Cell-specific expression and subcellular localization of neurophysin-CAT-fusion proteins expressed from oxytocin and vasopressin gene promoter-driven constructs in transgenic mice
    S W Jeong
    Laboratory of Neurochemistry, NINDS, Bethesda, Maryland 20892-4130, USA
    Exp Neurol 171:255-71. 2001
    ....
  27. pmc The role of the actin cytoskeleton in oxytocin and vasopressin release from rat supraoptic nucleus neurons
    Vicky A Tobin
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    J Physiol 582:1337-48. 2007
    ..TG-induced priming of somato/dendritic release was also blocked by jasplakinolide and latrunculin, suggesting that priming involves changes in actin remodelling...
  28. pmc Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans
    Caroline F Zink
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 30:7017-22. 2010
    ....
  29. pmc Phasic firing in vasopressin cells: understanding its functional significance through computational models
    Duncan J Macgregor
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Comput Biol 8:e1002740. 2012
    ..These findings show large differences in information coding between the populations, and apparent functional advantages of asynchronous phasic firing...
  30. pmc The neurophysiology of neurosecretory cells
    William E Armstrong
    Department of Anatomy and Neurobiology, Neuroscience Institute, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    J Physiol 585:645-7. 2007
  31. pmc Marital behavior, oxytocin, vasopressin, and wound healing
    Jean Philippe Gouin
    Department of Psychology, The Ohio State University, Columbus, OH 43210 1228, USA
    Psychoneuroendocrinology 35:1082-90. 2010
    ..These data confirm and extend prior evidence implicating oxytocin and vasopressin in couples' positive and negative communication behaviors, and also provide further evidence of their role in an important health outcome, wound healing...
  32. ncbi Chronic hypoosmolality induces a selective decrease in magnocellular neurone soma and nuclear size in the rat hypothalamic supraoptic nucleus
    B Zhang
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neuroendocrinol 13:29-36. 2001
    ..Our results therefore support the concept of global alterations in the synthetic activity of magnocellular OT and AVP neurones in response to extracellular osmolality...
  33. ncbi Autonomic and neuroendocrine responses to a psychosocial stressor in adults with autistic spectrum disorder
    Lucres M C Jansen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    J Autism Dev Disord 36:891-9. 2006
    ..However, in contrast to previous findings in low functioning autistic children, ASD adults showed increased basal oxytocin levels, which may be related to developmental factors...
  34. pmc Regulation of activity-dependent dendritic vasopressin release from rat supraoptic neurones
    Mike Ludwig
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    J Physiol 564:515-22. 2005
    ..Vasopressin itself is effective in inducing dendritic vasopressin release, but it is ineffective in producing priming...
  35. pmc Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia
    David G Harper
    Geriatric Psychiatry Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Brain 131:1609-17. 2008
    ....
  36. pmc The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy
    W S Young
    Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 49, Room 5A56, Bethesda, MD 20892 4483, USA
    Neuroscience 143:1031-9. 2006
    ..Finally, ISHH and RT-PCR showed expression of the Avpr1b gene in the rat and human hippocampi as well. We suggest that the CA2 field may form or retrieve associations (memories) between olfactory cues and social encounters...
  37. ncbi The effects of vasopressin on acute kidney injury in septic shock
    Anthony C Gordon
    Intensive Care Unit, Charing Cross Hospital, Imperial College NHS Trust, Fulham Palace Road, London W6 8RF, UK
    Intensive Care Med 36:83-91. 2010
    ..To compare the effects of vasopressin versus norepinephrine infusion on the outcome of kidney injury in septic shock...
  38. ncbi Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation
    G Aguilera
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bldg 10, Rm 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892 1862, USA
    Regul Pept 96:23-9. 2000
    ..The data suggest that vasopressinergic regulation of the HPA axis is critical for sustaining corticotroph responsiveness in the presence of high circulating glucocorticoid levels during chronic stress...
  39. ncbi Copeptin, a stable peptide derived from the vasopressin precursor, is elevated in serum of sepsis patients
    Joachim Struck
    Department of Research, BRAHMS Aktiengesellschaft, Neuendorfstr 25, D 16761 Hennigsdorf, Germany
    Peptides 26:2500-4. 2005
    ....
  40. ncbi The vasopressin system: physiology and clinical strategies
    Tanja A Treschan
    Klinik für Anästhesiologie und Intensivmedizin, Germany
    Anesthesiology 105:599-612; quiz 639-40. 2006
    ..The side effects of vasopressin and its analogs must be further characterized...
  41. ncbi Antidiuretic action of vasopressin: quantitative aspects and interaction between V1a and V2 receptor-mediated effects
    L Bankir
    INSERM Unité 367, 17 Rue du Fer a Moulin, 75005, Paris, France
    Cardiovasc Res 51:372-90. 2001
    ..4) Most likely, the different effects of VP require different levels of VP concentration to occur and are thus recruited successively with progressive rise in VP secretion...
  42. pmc Oxytocin, vasopressin and pair bonding: implications for autism
    Elizabeth A D Hammock
    Department of Psychiatry and Behavioural Sciences, Centre for Behavioural Neuroscience, Yerkes National Primate Research Centre, Emory University, Atlanta, GA 30329, USA
    Philos Trans R Soc Lond B Biol Sci 361:2187-98. 2006
    ....
  43. ncbi Alterations in forearm vascular reactivity in patients with septic shock
    P Kienbaum
    Klinik für Anaesthesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen, Germany
    Anaesthesia 63:121-8. 2008
    ..These findings exclude a generalised impairment of vasomotor activity in patients with septic shock and provide a rationale for vasopressin administration...
  44. ncbi Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats
    Karl Ebner
    Max Planck Institut fur Psychiatrie, Munchen, Germany
    Eur J Neurosci 15:384-8. 2002
    ..Taken together with previous findings the results of the present study suggest that AVP is released within septum and amygdala to balance the behavioural response during forced swimming...
  45. ncbi Endocrine effects of vasopressin in critically ill patients
    Tarek Sharshar
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Best Pract Res Clin Anaesthesiol 22:265-73. 2008
    ..The absence of endocrine effects of vasopressin during critical illness is unclear and may relate to an already maximal hormonal stimulation or to down-regulation of vasopressin receptors...
  46. ncbi C-terminal provasopressin (copeptin) in patients with community-acquired pneumonia--influence of antibiotic pre-treatment: results from the German competence network CAPNETZ
    Stefan Kruger
    Medical Clinic I, University Clinic RWTH Aachen, Germany
    J Antimicrob Chemother 64:159-62. 2009
    ..Recently, C-terminal provasopressin (copeptin) turned out to be predictive for mortality in community-acquired pneumonia (CAP). The aim of this study was to evaluate the influence of antibiotic pre-treatment on copeptin levels in CAP...
  47. ncbi Overview of cellular electrophysiological actions of vasopressin
    Mario Raggenbass
    Department of Basic Neurosciences, University Medical Center, CH 1211 Geneva 4, Switzerland
    Eur J Pharmacol 583:243-54. 2008
    ..Further progress will probably require the introduction of new techniques, such as targeted in vivo whole-cell recording, large-scale recordings from neuronal ensembles or in vivo imaging in small animals...
  48. ncbi Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock
    I Tsuneyoshi
    Division of Intensive Care Medicine, Kagoshima University Hospital, Kagoshima, Japan
    Crit Care Med 29:487-93. 2001
    ..To investigate the physiologic effects of exogenous vasopressin as a potential alternative to traditional high-dose catecholamine therapy for septic patients with vascular hyporeactivity to catecholamines...
  49. pmc Temporal and spatial expression patterns of canonical clock genes and clock-controlled genes in the suprachiasmatic nucleus
    Toshiyuki Hamada
    Department of Psychology, Columbia University, 1190 Amsterdam Avenue, New York, NY 10027, USA
    Eur J Neurosci 19:1741-8. 2004
    ..The results suggest that not only is the SCN organized into light-responsive and rhythmic regions but also that the rhythmic region of the SCN itself has an ordered arrangement of SCN oscillator cells...
  50. ncbi Central nitric oxide blocks vasopressin, oxytocin and atrial natriuretic peptide release and antidiuretic and natriuretic responses induced by central angiotensin II in conscious rats
    Wagner Luis Reis
    Laboratory of Neuroendocrinology, Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Exp Physiol 92:903-11. 2007
    ..Thus, the central nitrergic system can act to inhibit AVP, OT and ANP secretion and the antidiuretic and natriuretic effects in response to Ang II...
  51. ncbi State-dependent plasticity in vasopressin neurones: dehydration-induced changes in activity patterning
    V Scott
    Centre for Neuroendocrinology and Department of Physiology, Otago School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
    J Neuroendocrinol 22:343-54. 2010
    ..We review recent advances in our understanding of the physiological regulation of vasopressin neurone activity patterning and the mechanisms by which this is altered to cope with the increased secretory demands of dehydration...
  52. ncbi Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus
    Joris H Robben
    Department of Physiology, Nijmegen Centre for Molecular Life Sciences and Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 291:F257-70. 2006
    ..Also, the increased understanding of these cellular defects in NDI has opened exciting initiatives in the development of novel therapies for NDI, which are extensively discussed in this review...
  53. ncbi Dopamine inhibits vasopressin action in the rat inner medullary collecting duct via alpha(2)-adrenoceptors
    R M Edwards
    Department of Renal Urology Biology, GlaxoSmithKline, King of Prussia, Pennsylvania 19406 0939, USA
    J Pharmacol Exp Ther 298:1001-6. 2001
    ..We conclude that the inhibitory effects of dopamine on AVP-induced Pf and cAMP accumulation in the rat IMCD are mediated via alpha(2)-adrenoceptors...
  54. ncbi Survival with full neurologic recovery after prolonged cardiopulmonary resuscitation with a combination of vasopressin and epinephrine in pigs
    Karl H Stadlbauer
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    Anesth Analg 96:1743-9, table of contents. 2003
    ..In conclusion, in this porcine model of prolonged CPR, repeated vasopressin/epinephrine administration, but not epinephrine or saline placebo alone, ensured long-term survival with full neurologic recovery...
  55. ncbi Bistability with hysteresis in the activity of vasopressin cells
    N Sabatier
    Centre for Integrative Physiology, University of Edinburgh College of Medical and Veterinary Sciences, Edinburgh, UK
    J Neuroendocrinol 19:95-101. 2007
    ..We note that these filtering characteristics are the opposite of the filtering characteristics that are typically associated with neurones...
  56. ncbi The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho
    Grazia Tamma
    Forschungsinstitut fur Molekulare Pharmakologie, Campus Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin, Germany
    J Cell Sci 116:3285-94. 2003
    ..The data suggest that the signaling pathway underlying the diuretic effects of PGE2 and probably those of other diuretic agents include cAMP- and Ca2+-independent Rho activation and F-actin formation...
  57. ncbi Water transport across mammalian cell membranes
    A S Verkman
    Department of Medicine, University of California, San Francisco 94143, USA
    Am J Physiol 270:C12-30. 1996
    ..Further work should be directed at elucidation of the role of water channels in normal physiology and disease, molecular analysis of regulatory mechanisms, and water channel structure determination at atomic resolution...
  58. ncbi Modelling the in vivo spike activity of phasically-firing vasopressin cells
    T F Clayton
    Institute of Integrated Micro and Nano Systems, University of Edinburgh, Edinburgh, UK
    J Neuroendocrinol 22:1290-300. 2010
    ..In the model, the long-term behaviour (phasic characteristics) of cells is largely independent of the short-term behaviour (interspike intervals)...
  59. pmc X-chromosome dosage affects male sexual behavior
    Paul J Bonthuis
    Neuroscience Graduate Program and Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Horm Behav 61:565-72. 2012
    ..We speculate that expression levels of a yet to be discovered gene(s) on the X-chromosome may affect sexual behavior in mice and perhaps in other mammals...
  60. ncbi Identification of cell-specific messenger ribonucleic acids in oxytocinergic and vasopressinergic magnocellular neurons in rat supraoptic nucleus by single-cell differential hybridization
    Mitsuo Yamashita
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 143:4464-76. 2002
    ....
  61. pmc Performance, properties and plasticity of identified oxytocin and vasopressin neurones in vitro
    W E Armstrong
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Neuroendocrinol 22:330-42. 2010
    ..In conclusion, the differences in VP and OT neuronal function are underlain by differences in both membrane and synaptic properties, and differentially modulated by reproductive state...
  62. ncbi Low-dose vasopressin infusion in patients with severe vasodilatory hypotension after prolonged hemorrhage during general anesthesia
    Isao Tsuneyoshi
    Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Anesth 19:170-3. 2005
    ..During vasodilatory shock after prolonged and severe hemorrhage, VP seems to be effective in reversing hypotension and decreasing the need for exogenous cathecholamines while preserving cardiac function and critical organ blood flow...
  63. pmc Vasopressin and epinephrine in the treatment of cardiac arrest: an experimental study
    Konstantinos Stroumpoulis
    University of Athens, Medical School, Department of Experimental Surgery and Surgical Research, Agiou Thoma Street, Athens, Greece
    Crit Care 12:R40. 2008
    ..The aim of the present study is to assess whether the combination of vasopressin and epinephrine, given their different mechanisms of action, provides better results than epinephrine alone in cardiopulmonary resuscitation...
  64. ncbi Opposite potentiality of hypothalamic coexpressed neuropeptides, apelin and vasopressin in maintaining body-fluid homeostasis
    Catherine Llorens-Cortes
    INSERM, U 691, Paris, France
    Prog Brain Res 170:559-70. 2008
    ....
  65. pmc Phasic spike patterning in rat supraoptic neurones in vivo and in vitro
    Nancy Sabatier
    School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK
    J Physiol 558:161-80. 2004
    ..Despite superficial similarities in the phasic firing patterns observed in vivo and in vitro, there are thus fundamental differences in the underlying mechanisms...
  66. ncbi [Vasopressin]
    W Schummer
    Anaesthesist 54:707-8. 2005
  67. ncbi Selective gene expression in magnocellular neurons in rat supraoptic nucleus
    Noriko Mutsuga
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:7174-85. 2004
    ....
  68. ncbi Vasopressin in hemorrhagic shock
    Ram M Sharma
    Department of Anaesthesiology and Critical Care, Armed Forces Medical College, Pune 411040, India
    Anesth Analg 101:833-4, table of contents. 2005
    ..The possible role of small-dose infusions of vasopressin in fluid- and catecholamine-resistant hemorrhagic shock is discussed...
  69. ncbi Infusion of low-dose vasopressin improves left ventricular function during separation from cardiopulmonary bypass: a double-blind randomized study
    Ahmed Said Elgebaly
    Department of Anesthesia and SICU, Faculty of Medicine, Tanta University, Egypt
    Ann Card Anaesth 15:128-33. 2012
    ....
  70. ncbi AHP's, HAP's and DAP's: how potassium currents regulate the excitability of rat supraoptic neurones
    Peter Roper
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Comput Neurosci 15:367-89. 2003
    ..We then show how these currents regulate the excitability of these cells and consequently shape their discharge pattern...
  71. ncbi EGFP-tagged vasopressin precursor protein sorting into large dense core vesicles and secretion from PC12 cells
    Bing Jun Zhang
    Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, NIH, Bethesda, Maryland 20892, USA
    Cell Mol Neurobiol 25:581-605. 2005
    ..These data are consistent with the view that routing of the precursor to LDCVs requires the amino acids that encode the intravesicular chaperone, neurophysin...
  72. ncbi New determinants of firing rates and patterns of vasopressinergic magnocellular neurons: predictions using a mathematical model of osmodetection
    Louis Nadeau
    Neurosciences and Université Laval, Centre de Recherche du CHUQ CHUL, Quebec, G1V 4G2, Canada
    J Comput Neurosci 31:441-51. 2011
    ..027 Hz/Hz [IPSP]). The use of the realistic MCN model developed here allows for an improved understanding of the determinants driving the firing patterns and spiking frequencies of vasopressinergic magnocellular neurons...
  73. ncbi Endogenous activation of supraoptic nucleus kappa-opioid receptors terminates spontaneous phasic bursts in rat magnocellular neurosecretory cells
    Colin H Brown
    Centre for Neuroendocrinology and Department of Physiology, School of Medical Sciences, University of Otago, P O Box 913, Dunedin, New Zealand
    J Neurophysiol 95:3235-44. 2006
    ..By contrast, dendritic dynorphin release does not greatly influence the membrane potential between bursts and evidently does not influence the timing of burst initiation...
  74. ncbi Aquaporin-2 urinary excretion in preterm infants: relationship to diuresis and vasopressin
    S Iacobelli
    Department of Paediatrics, University Hospital of Dijon, France
    Acta Physiol (Oxf) 200:339-45. 2010
    ....
  75. ncbi Muscarinic receptor modulation of slow afterhyperpolarization and phasic firing in rat supraoptic nucleus neurons
    Masoud Ghamari-Langroudi
    Centre for Research in Neuroscience, Montreal General Hospital and McGill University, Montreal, Quebec H3G 1A4, Canada
    J Neurosci 24:7718-26. 2004
    ..Muscarinic inhibition of the sAHP provides an effective mechanism for promoting phasic firing in MNCs...
  76. ncbi Immunohistochemical localization of the vasopressin V1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin
    F Hernando
    Section of Molecular Science, Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, 3584 CG Utrecht, The Netherlands
    Endocrinology 142:1659-68. 2001
    ..These data suggest that the V1bR mediates different physiological functions of VP in the brain...
  77. ncbi In vivo modulation of post-spike excitability in vasopressin cells by kappa-opioid receptor activation
    C H Brown
    Department of Biomedical Sciences, University Medical School, Edinburgh, UK
    J Neuroendocrinol 12:711-4. 2000
    ....
  78. ncbi Survival with full neurologic recovery and no cerebral pathology after prolonged cardiopulmonary resuscitation with vasopressin in pigs
    V Wenzel
    Department of Anesthesiology and Critical Care Medicine, The Leopold Franzens University of Innsbruck, Austria
    J Am Coll Cardiol 35:527-33. 2000
    ..We sought to determine the effects of vasopressin and saline placebo in comparison with epinephrine on neurologic recovery and possible cerebral pathology in an established porcine model of prolonged cardiopulmonary resuscitation (CPR)...
  79. ncbi Aquaporin-2 water channels in spontaneously hypertensive rats
    Michele Buemi
    Nephrology, Department of Internal Medicine, University of Messina, Messina, Italy
    Am J Hypertens 17:1170-8. 2004
    ..The PAVP appeared to be higher in OPC-treated rats from both strains. These findings suggest that AVP and the AQP2 are involved in the pathogenesis of hypertension in SHR...
  80. ncbi The identification of a cis-acting element involved in cyclic 3',5'-adenosine monophosphate regulation of bovine vasopressin gene expression
    K Pardy
    Neuropeptide Laboratory, National University of Singapore
    J Biol Chem 267:21746-52. 1992
    ..These data demonstrate that cAMP regulates bovine VP gene expression in vitro via a cis-acting element within the VP promoter, and this activation may be mediated by members of the AP1/ATF/CREB family of transcription factors...
  81. ncbi Vasopressin and its immune effects in septic shock
    James A Russell
    Heart and Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada
    J Innate Immun 2:446-60. 2010
    ..Vasopressin plus corticosteroid treatment may decrease mortality compared to corticosteroids plus norepinephrine. Potential mechanisms are that vasopressin plus corticosteroids beneficially alter immunity in septic shock...
  82. ncbi Arginine-vasopressin mediates central and peripheral glucose regulation in response to carotid body receptor stimulation with Na-cyanide
    Sergio Montero
    CUIB, Universidad de Colima, Ave 25 de Julio s n, Colima, Col 28045, Mexico
    J Appl Physiol (1985) 100:1902-9. 2006
    ..These results suggest that AVP is a mediator of the hyperglycemic reflex and cerebral glucose retention following CBR stimulation. We propose that hepatic activation of AVP V1a receptors is essential for this hyperglycemic response...
  83. pmc Dehydration-induced modulation of kappa-opioid inhibition of vasopressin neurone activity
    Victoria Scott
    Department of Physiology, University of Otago, Dunedin 9054, New Zealand
    J Physiol 587:5679-89. 2009
    ....
  84. ncbi Vasopressin or epinephrine for out-of-hospital cardiac arrest
    Peter C Wyer
    Emergency Medicine Residency Program, New York Presbyterian Hospital, New York, NY, USA
    Ann Emerg Med 48:86-97. 2006
    ..We performed an evidence-based emergency medicine review of evidence comparing vasopressin to epinephrine in structured cardiac arrest protocols...
  85. ncbi C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study
    Sohail Q Khan
    University of Leicester, Department of Cardiovascular Sciences, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Circulation 115:2103-10. 2007
    ..We compared the prognostic value of copeptin and an established marker, N-terminal pro-B-type natriuretic peptide (NTproBNP), after acute myocardial infarction...
  86. ncbi Synthesis, transport, and release of posterior pituitary hormones
    M J Brownstein
    Science 207:373-8. 1980
    ..The precursors seem to be processed into smaller, biologically active molecules while they are being transported along the axon...
  87. ncbi A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation
    Volker Wenzel
    Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
    N Engl J Med 350:105-13. 2004
    ..Vasopressin is an alternative to epinephrine for vasopressor therapy during cardiopulmonary resuscitation, but clinical experience with this treatment has been limited...
  88. pmc A comprehensive description of the transcriptome of the hypothalamoneurohypophyseal system in euhydrated and dehydrated rats
    Charles Hindmarch
    The Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, England
    Proc Natl Acad Sci U S A 103:1609-14. 2006
    ..We suggest that these differentially expressed genes represent candidate regulators and effectors of HNS activity and remodeling...
  89. pmc Science review: Vasopressin and the cardiovascular system part 1--receptor physiology
    Cheryl L Holmes
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Crit Care 7:427-34. 2003
    ..In part 2 of the review we discuss the effects of vasopressin on vascular smooth muscle and the heart, and we summarize clinical studies of vasopressin in shock states...
  90. ncbi Regulation of gene expression in magnocellular neurons in rat supraoptic nucleus during sustained hypoosmolality
    Noriko Mutsuga
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 146:1254-67. 2005
    ..These results indicate that the hypoosmolar state is accompanied by a global, but selective, increase in expression of a wide variety of regulatory genes in the SON...
  91. ncbi Terlipressin: vasopressin analog and novel drug for septic shock
    Adam B Pesaturo
    Department of Pharmacy Services, Saint Joseph HealthCare, Inc, Lexington, KY, USA
    Ann Pharmacother 40:2170-7. 2006
    ..To review and assess available literature on chemistry, pharmacology, pharmacodynamics, pharmacokinetics, clinical studies, adverse events, drug interactions, and dosing and administration of terlipressin in septic shock...
  92. ncbi Regulatory domains in the intergenic region of the oxytocin and vasopressin genes that control their hypothalamus-specific expression in vitro
    Raymond L Fields
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 23:7801-9. 2003
    ..Alignment of the DNA sequences in the 178 and 430 bp domains reveals four common sequences (motifs) that may be candidates for the putative enhancers in the IGR that regulate OT and VP gene hypothalamic-specific expression...
  93. ncbi ATP elicits inward currents in isolated vasopressinergic neurohypophysial terminals via P2X2 and P2X3 receptors
    Thomas K Knott
    Department of Physiology and Program in Neuroscience, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Pflugers Arch 450:381-9. 2005
    ..We speculate that the characteristics of these types of receptors reflect the function of co-released ATP in the terminal compartment of these and other CNS neurons...
  94. ncbi Epinephrine and vasopressin during cardiopulmonary resuscitation
    Jing Quan Zhong
    Department of Medicine, University of Toronto and Division of Cardiology, St Michael s Hospital, 30 Bond St, 6 027 Queen Wing, Toronto, Ont, Canada M5B 1W8
    Resuscitation 66:263-9. 2005
    ..The combination of epinephrine and vasopressin may be effective, but has been incompletely studied. Clinical trials of vasopressor agents, which minimize direct myocardial effects are needed...
  95. ncbi Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis
    Lucinda K Barrett
    Wolfson Institute for Biomedical Research, and the Department of Medicine, University College London, London, UK
    Crit Care Med 35:2337-43. 2007
    ..We investigated whether a long-term rodent model of sepsis would produce changes in endogenous levels and pressor reactivity to exogenous norepinephrine and vasopressin comparable with those seen in septic patients...
  96. ncbi Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking
    Hua A J Lu
    Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 282:28721-32. 2007
    ..To summarize, we have identified the 70-kDa heat shock proteins as a AQP2 interactors and have shown for hsc70 that this interaction is involved in AQP2 trafficking...
  97. ncbi The effect of vasopressin on gastric perfusion in catecholamine-dependent patients in septic shock
    Frank M P van Haren
    Department of Intensive Care Medicine, Jeroen Bosch Hospital, PO Box 90153, 5200 ME s Hertogenbosch, The Netherlands
    Chest 124:2256-60. 2003
    ..To study the effect of continuous infusion of vasopressin on the splanchnic circulation in patients with severe septic shock...
  98. pmc Reversed polarized delivery of an aquaporin-2 mutant causes dominant nephrogenic diabetes insipidus
    Erik Jan Kamsteeg
    Department of Physiology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Research Tower, 7th Floor, Geert 30, PO Box 9101, Nijmegen 6500 HB, The Netherlands
    J Cell Biol 163:1099-109. 2003
    ..Our data reveal a novel cellular phenotype in dominant NDI and show that dominance of basolateral sorting motifs in a mutant subunit can be the molecular basis for disease...
  99. ncbi Is vasopressin superior to adrenaline or placebo in the management of cardiac arrest? A meta-analysis
    Giuseppe G L Biondi-Zoccai
    Institute of Cardiology, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
    Resuscitation 59:221-4. 2003
    ..Evidence in humans is still limited and confidence intervals estimates too wide to reliably confirm or disprove results obtained in experimental animal settings...
  100. ncbi Effects of the vasopressin V1 agonist [Phe2,Ile3,Orn8]] vasopressin on regional kidney perfusion and renal excretory function in anesthetized rabbits
    R G Evans
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Cardiovasc Pharmacol 32:571-81. 1998
    ....
  101. ncbi Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock
    Luzius B Hiltebrand
    Department of Anesthesia, University of Bern, Inselspital, Bern, Switzerland, and Department of Anesthesia and Intensive Care Medicine, Landspitali University Hospital, Reykjavik, Iceland
    Anesthesiology 106:1156-67. 2007
    ..The authors studied the effects of vasopressin on microcirculatory blood flow in the entire gastrointestinal tract in anesthetized pigs during early septic shock...

Research Grants67

  1. The Neural Basis of Sexually Dimorphic Brain Function
    GEERT DE VRIES; Fiscal Year: 2007
    ..abstract_text> ..
  2. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ....
  3. Neuropeptide regulation of neurohypophyseal function
    Francis W Flynn; Fiscal Year: 2012
    ..The nuclear translocation of the neurokinin receptor to the nucleus is novel and has implications for a large number of pathologies, such as epilepsy, that are linked to this receptor system in the brain. ..
  4. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ....
  5. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ....
  6. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
    ..This knowledge will provide insights into new drug targets to prevent, treat, and ultimately cure mental illness. ..
  7. Epithelial Sodium Channels in the Supraoptic Vasopressin and Oxytocin Neurons
    Ryoichi Teruyama; Fiscal Year: 2009
    ..The research in this proposal will elucidate this critical mechanism, and will increase our ability to manage hypertension. ..
  8. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..An understanding of the fetal mechanisms associated with sex differences in MOD will have etiologic imolications and imoortance for the development of sex-specific treatments and prevention of MOD. ..
  9. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    JAMES ANTHONY SHEERIN MULDOWNEY; Fiscal Year: 2013
    ..With the overwhelming prevalence of vascular disease nationally, and worldwide, new insights and strategies have the potential translate to a tremendous public health impact...
  10. Aquaporin-2 (AQP2) Regulation by AMP-activated kinase(AMPK) in the Kidney Collec
    Mohammad Al-Bataineh; Fiscal Year: 2012
    ..In addition, it may provide insight into the treatment of important body water balance disorders like nephrogenic diabetes insipidus. ..
  11. Epithelial Sodium Channels in Vasopressin and Oxytocin Synthesizing Magnocellular
    Ryoichi Teruyama; Fiscal Year: 2013
    ..Results from this proposed project will provide critical information concerning central ENaC inhibition as a potential new target in the treatment of cardiovascular disease (10). ..
  12. Cell Surface Plasminogen Activation and Hypertension
    Robert J Parmer; Fiscal Year: 2013
    ....
  13. Sex Differences in the Roles of Oxytocin and Vasopressin in Social Withdrawal
    Michael Q Steinman; Fiscal Year: 2013
    ..Together these experiments should provide insight into whether OT and AVP play a role in the development and expression of social withdrawal. ..
  14. TRAFFIC REGULATORY PROTEINS AND ENAC
    Raymond A Frizzell; Fiscal Year: 2013
    ..This work is expected to reveal new regulators and therapeutic targets for the control of sodium and fluid transport in the kidney. ..
  15. DEPOLARIZATION-SECRETION COUPLING IN NERVE TERMINALS
    Jose R Lemos; Fiscal Year: 2012
    ..Only then can therapeutic drugs be targeted to physiologically relevant purinergic receptors to alleviate such diseases. ..
  16. Cellular/molecular Na,K-ATPase regulation in choroid plexus
    Kathleen J Sweadner; Fiscal Year: 2010
    ....
  17. Genes Influencing Social Behaviors
    DONALD WELLS PFAFF; Fiscal Year: 2010
    ..Impact: OT may be involved in postpartum depression. OT systems certainly facilitate social recognition, disorders of which are prominent in autism and in schizophrenia. ..
  18. BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATION
    ELIZABETH ANNE EIPPER; Fiscal Year: 2013
    ..Both enzymatic activities of PAM have been extensively studied and their enzymology and biology, along with the biological consequences of inadequate ability to perform peptide amidation, form the basis of this work. ..
  19. Screening New Therapeutics for the Treatment of Post Traumatic Stress Disorder
    NEAL GORDON SIMON; Fiscal Year: 2011
    ..This proposal will use a unique predatory fear conditioning paradigm as a preclinical model to test the feasibility of using novel V1a antagonists as a potential new pharmacotherapy for PTSD. ..
  20. Targeted Plasma Peptidomics: Endogenous Mu-Opioid Receptor Peptides
    Brian Reed; Fiscal Year: 2013
    ....
  21. PHYSIOLOGICAL DISSECTION OF THE SCN
    Rae Silver; Fiscal Year: 2010
    ..The work also contributes to a better understanding of circadian changes associated with puberty, andropause, sleep regulation and some aspects of sex differences. ..
  22. ELECTROPHYSIOLOGICAL CORRELATES OF VASOPRESSIN RELEASE
    William E Armstrong; Fiscal Year: 2011
    ..Furthermore, phasic, bursting activity is exhibited in many neurons and endocrine cells, so the mechanisms we uncover may aide in the general understanding of patterned activity. ..
  23. Role of the CNS in Inappropriate Vasopressin Release Associated with Cirrhosis
    JOSEPH D WALCH; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The results from these studies will determine the mechanisms that contribute to the pathophysiology of fluid retention in a chronic disease state that is reported to be the 5th leading cause of death in the USA. ..
  24. ADOLESCENT ANABOLIC STEROIDS, VASOPRESSIN AND AGGRESSION
    Richard H Melloni; Fiscal Year: 2013
    ....
  25. Regulation of Renal Response to Vasopressin by Glycogen Synthase
    Reena Rao; Fiscal Year: 2013
    ..Through these studies we exoect to identify the mechanism by which GSK3 regulates AVP signaling in the renal collecting duct and its physiological and pathophysiological significance. ..
  26. Epithelial Sodium Channel Trafficking
    Peter M Snyder; Fiscal Year: 2013
    ..This may have important implications for our understanding and treatment of diseases including hypertension and cystic fibrosis. ..
  27. Vasopressin in the regulation of serotonin and anxiety
    BENJAMIN DAVID ROOD; Fiscal Year: 2013
    ..abstract_text> ..
  28. DNA/RNA G-Quadruplexes: Structures, Transitions and Recognition
    Dinshaw J Patel; Fiscal Year: 2013
    ....
  29. Interactive effects of ethanol and estrogen on brain vasopressin during puberty
    Toni R Pak; Fiscal Year: 2010
    ....
  30. Regulation of Urea Transport in Diabetic Rat Kidney
    Janet Klein; Fiscal Year: 2009
    ..Rationale: angiotensin II increases phosphorylation of UT-A1 in rat IMCDs through PKC. We have preliminary data showing that PKC inhibition reduces UT-A1 phosphorylation in inner medulla from diabetic rats. ..
  31. Social attachment and reproductive regulation
    HEATHER ELIZABETH WATTS; Fiscal Year: 2010
    ..LAY SUMMARY: Social relationships influence both mental and reproductive health in humans. This study investigates neural mechanisms by which social attachments are formed and by which social interactions influence reproduction. ..
  32. Characterization of AQP2 interacting proteins and novel functions of AQP2
    HUA A LU; Fiscal Year: 2010
    ..Multidisciplinary approaches and powerful technologies will be used to carry out these studies that will shed light on the mechanism of AQP2 trafficking and function. ..
  33. Design & Synthesis of Novel CNS-Active Oxytocin and Vasopressin Receptor Ligands
    Edward Roberts; Fiscal Year: 2010
    ....
  34. OVARIAN HORMONE REGULATION OF LHRH BIOSYNTHESIS
    Sandra L Petersen; Fiscal Year: 2010
    ..Finally, the results of these studies may provide key insights into how E2 regulates such diverse functions as sex-specific neurodevelopment, neuroprotection and neurodegeneration ..
  35. Phosphorylation-dependent regulation of epithelial sodium channel (ENaC) traffick
    Xiubin Liang; Fiscal Year: 2012
    ..Through this study, we will advance our understanding of molecular mechanisms of ENaC regulation and the results will provide further insight into the control of sodium balance, blood volume and thereby of blood pressure. ..
  36. Transgenic Targeting of Vascular G Protein Signaling
    Karsten Peppel; Fiscal Year: 2010
    ..Data from these experiments should also increase our understanding of 21AR signaling in the setting of high blood pressure and help in the development of novel antihypertensive therapeutic strategies. ..
  37. Optical Study of Secretion in Mammalian Nerve Terminals
    BRIAN MATTHEW SALZBERG; Fiscal Year: 2013
    ..abstract_text> ..
  38. Novel treatment for polycystic kidney disease
    Vicente E Torres; Fiscal Year: 2013
    ..g. recently described PDE activators). ..
  39. The role of vasopressin in the social deficits of autism
    Karen J Parker; Fiscal Year: 2013
    ..This research has high potential to lead to the development of the first effective treatments and earlier interventions for social impairments in individuals wth autism. ..
  40. Central Kappa Opioid Neural Regulation of Cardiovascular and Renal Function
    Helmut B Gottlieb; Fiscal Year: 2012
    ..Ultimately, opioid compounds can be developed and used to treat fluid overload/hyponatremia in susceptible patients and improvement of one's quality of life. ..
  41. Etiology of microvascular changes in Gram-positive sepsis: mechanisms and therape
    Perenlei Enkhbaatar; Fiscal Year: 2013
    ..We are particularly optimistic about the possibility that the proposed research will lead to translational clinical studies for agonists of the selective V1aR and peroxynitrite modulators. ..
  42. Role of the PVN in Chronic Intermittent Hypoxia-Induced Cardiorespiratory Changes
    Prabha Kc; Fiscal Year: 2012
    ..The attainment of this award will make me independent In pursuing my career goal to study the role of the PVN In mediating stress-related autonomic disturbances. ..
  43. Ethanol-induced conditioned partner preference in mice
    Ruth I Wood; Fiscal Year: 2013
    ..Aim 3 will test the ability of a V1a receptor antagonist to block EtOH-induced conditioned partner preference. Together, these studies represent an essential first-step to understand substance abuse and social bonding in mice. ..
  44. Adenylyl cyclase isoforms in collecting duct physiology and pathophysiology
    Donald E Kohan; Fiscal Year: 2013
    ....
  45. Ligand-independent signaling of estrogen receptor beta and the aging brain
    Toni R Pak; Fiscal Year: 2013
    ..The expected results will further our understanding of ER2 signaling in the post-menopausal brain by elucidating the precise molecular mechanisms that drive estrogen-independent regulation of ER2 target genes. ..
  46. Role of adenylyl cyclase isoforms in collecting duct physiology &pathophysiology
    Donald E Kohan; Fiscal Year: 2013
    ....
  47. A Potential New Drug for Depression
    EVE DAMIANO; Fiscal Year: 2009
    ..These limitations demonstrate that a new treatment approach through vasopressin receptor antagonism in the brain may offer significant opportunities for improved outcomes with substantial societal benefit. ..
  48. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    Olivier George; Fiscal Year: 2013
    ..abstract_text> ..
  49. Paternal Care, Affiliation and Vasopressin: Mechanisms of Monogamy
    Alexander G Ophir; Fiscal Year: 2012
    ..Study of the social environment of developing offspring will provide insight into the importance of paternal care on child health and development and its ultimate importance in offspring behavior as adults. ..
  50. Neural Control of Vasopressin Release
    J Thomas Cunningham; Fiscal Year: 2013
    ..The findings of these experiments could potentially alter the way that inappropriate vasopressin release is studied and conceptualized clinically. ..
  51. FETAL CARDIOVASCULAR AND ENDOCRINE REFLEX RESPONSES
    Charles E Wood; Fiscal Year: 2013
    ..The results are likely to demonstrate the importance of NMDA receptor blockade as a neuroprotective strategy in late gestation fetuses and for premature infants in the NICU. ..
  52. Targeted Treatment of Recurrent Small Cell Lung Cancer with Anti-AbnV2 Antibodies
    Roy H L Pang; Fiscal Year: 2011
    ..The proposed research is expected to lead to new successful therapies for managing recurrent SCLC, thereby leading to a higher long- term survival rate for these patients. ..
  53. Role of Notch signaling in the Development and Guidance of Hypothalamic Neurons
    PAVEN AUJLA; Fiscal Year: 2013
    ..Results from these studies will provide insight into the role of Notch signaling in the functional development of hypothalamic neurons and may reveal genetic causes of congenital HP dysfunction. ..
  54. The Impact of Vasopressin on Mitochondrial Dysfunction in Hemorrhagic Shock
    CARRIE ADELIA SIMS; Fiscal Year: 2013
    ....
  55. CELLULAR BIOLOGY OF RENAL FUNCTION AND DISEASE
    Dennis Brown; Fiscal Year: 2012
    ....
  56. Central amygdala input circuits control stress-induced anxiety after chronic ETOH
    Garret D Stuber; Fiscal Year: 2013
    ....
  57. An animal model of parental care: Manipulating social environments with V1aR-RNAi
    Steven M Phelps; Fiscal Year: 2010
    ..We propose to develop a unique combination of molecular and behavioral tools that would allow researchers to address more complex interactions between social environment, gene expression, and neurobiological and behavioral development. ..
  58. Upstream Regulation of Kiss1 Cells
    Horacio O de la Iglesia; Fiscal Year: 2010
    ..abstract_text> ..
  59. Neuroendocrine Control of Paternal Care in the Common Marmoset
    Toni Elaine Ziegler; Fiscal Year: 2010
    ..With poor parenting or parental absence, there are a number of psychosocial disorders that confound human health. Fathers can contribute significantly to the positive outcome of infant and child development. ..
  60. Multiple circadian oscillators: Regulation of a neuroendocrine rhythm
    Sandra J Legan; Fiscal Year: 2012
    ....
  61. Cyclic AMP Signaling Affects Urine Concentration through UT-A1
    Mitsi A Blount; Fiscal Year: 2012
    ..We hope to clarify the mechanisms of urea movement to potentially provide insight into the treatment of disregulation of the body's water homeostasis. ..
  62. Central Renin-Angiotensin System: Metabolism, Fluid Balance, and Hypertension
    Justin L Grobe; Fiscal Year: 2013
    ..Together, these mechanisms synergistically act to positively influence metabolic rate. Examination of these mechanisms will likely lead to the identification of novel therapeutic targets for metabolic diseases. ..
  63. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA E O'DONNELL; Fiscal Year: 2013
    ..We will also assess the efficacy of NKCC, NHE and NBC inhibitors for reduction of edema when administered after the onset of ischemia. ..
  64. Neuropeptide Regulation Vasopressin/Oxytocin Secretion
    CELIA SLADEK; Fiscal Year: 2006
    ..Understanding the role of specific neurotransmitters in relaying hemodynamic information to the VP and OT neurons is central to manipulating the system for treatment of pathological conditions. ..
  65. Mechanism of Vasopressin-Mediated Placental Vascular Resistance after Fetal Bypas
    Pirooz Eghtesady; Fiscal Year: 2010
    ..Using a standard sheep model our study will examine the use of medications that would protect the placenta during fetal open heart surgery. In this way we can perfect our techniques before attempting this procedure in human babies. ..
  66. CIRCADIAN REGULATION OF VASOPRESSIN GENE EXPRESSION
    Joseph Majzoub; Fiscal Year: 1993
    ..Transgenic Brattleboro rats bearing mutant rat VP genes will also be prepared to evaluate the impact of dysfunctional VP genes on the mRNA tail and secretory rhythms...
  67. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....