natriuretic peptides

Summary

Summary: Peptides that regulate the WATER-ELECTROLYTE BALANCE in the body, also known as natriuretic peptide hormones. Several have been sequenced (ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; C-TYPE NATRIURETIC PEPTIDE).

Top Publications

  1. ncbi Left ventricular assist device support reverses altered cardiac expression and function of natriuretic peptides and receptors in end-stage heart failure
    Michaela Kuhn
    Institute of Pharmacology and Toxicology and Interdisciplinary Center for Clinical Research, Universitatsklinikum Munster, Domagkstrasse 12, D 48129 Munster, Germany
    Cardiovasc Res 64:308-14. 2004
  2. ncbi Natriuretic peptides and therapeutic applications
    Candace Y W Lee
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55906, USA
    Heart Fail Rev 12:131-42. 2007
  3. pmc Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
    Marica Bordicchia
    Metabolic Signaling and Disease Program, Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, USA
    J Clin Invest 122:1022-36. 2012
  4. ncbi Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions
    Lincoln R Potter
    Department of Biochemistry, Molecular Biology, and Biophysics, 6 155 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Endocr Rev 27:47-72. 2006
  5. pmc Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals
    Susan Cheng
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 108:979-84. 2011
  6. pmc Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
    Abigail May Khan
    Cardiology Division, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3242-9. 2011
  7. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
  8. ncbi Natriuretic peptides: physiologic and analytic considerations
    Torbjørn Omland
    Akershus University Hospital, Lørenskog, Norway
    Heart Fail Clin 5:471-87. 2009
  9. ncbi Brain and other natriuretic peptides: molecular aspects
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouwziekenhuis, Moorselbaan 164, 9400 Aalst, Belgium
    Eur J Heart Fail 6:261-8. 2004
  10. ncbi Natriuretic peptides and heart failure in the patient with chronic kidney disease: a review of current evidence
    S Dhar
    Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Postgrad Med J 85:299-302. 2009

Detail Information

Publications277 found, 100 shown here

  1. ncbi Left ventricular assist device support reverses altered cardiac expression and function of natriuretic peptides and receptors in end-stage heart failure
    Michaela Kuhn
    Institute of Pharmacology and Toxicology and Interdisciplinary Center for Clinical Research, Universitatsklinikum Munster, Domagkstrasse 12, D 48129 Munster, Germany
    Cardiovasc Res 64:308-14. 2004
    ....
  2. ncbi Natriuretic peptides and therapeutic applications
    Candace Y W Lee
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55906, USA
    Heart Fail Rev 12:131-42. 2007
    ..been tremendous progress in our understanding of the physiologic, diagnostic and therapeutic roles of the natriuretic peptides (NPs) in health and disease...
  3. pmc Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
    Marica Bordicchia
    Metabolic Signaling and Disease Program, Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, USA
    J Clin Invest 122:1022-36. 2012
    ..As cardiac natriuretic peptides (NPs) and β-AR agonists are similarly potent at stimulating lipolysis in human adipocytes, we investigated ..
  4. ncbi Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions
    Lincoln R Potter
    Department of Biochemistry, Molecular Biology, and Biophysics, 6 155 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Endocr Rev 27:47-72. 2006
    b>Natriuretic peptides are a family of structurally related but genetically distinct hormones/paracrine factors that regulate blood volume, blood pressure, ventricular hypertrophy, pulmonary hypertension, fat metabolism, and long bone ..
  5. pmc Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals
    Susan Cheng
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 108:979-84. 2011
    b>Natriuretic peptides have important roles in the regulation of vasomotor tone, salt homeostasis, and ventricular remodeling...
  6. pmc Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
    Abigail May Khan
    Cardiology Division, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3242-9. 2011
    The natriuretic peptides play an important role in salt homeostasis and blood pressure regulation...
  7. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
    We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties...
  8. ncbi Natriuretic peptides: physiologic and analytic considerations
    Torbjørn Omland
    Akershus University Hospital, Lørenskog, Norway
    Heart Fail Clin 5:471-87. 2009
    b>Natriuretic peptides play a central role in cardiovascular, endocrine, and renal homeostasis and can be considered physiologic antagonists to the renin-angiotensin-aldosterone system...
  9. ncbi Brain and other natriuretic peptides: molecular aspects
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouwziekenhuis, Moorselbaan 164, 9400 Aalst, Belgium
    Eur J Heart Fail 6:261-8. 2004
    b>Natriuretic peptides have emerged as important candidates for development of diagnostic tools and therapeutic agents in cardiovascular disease...
  10. ncbi Natriuretic peptides and heart failure in the patient with chronic kidney disease: a review of current evidence
    S Dhar
    Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Postgrad Med J 85:299-302. 2009
    b>Natriuretic peptides such as brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) are commonly used in the diagnosis and evaluation of heart failure...
  11. ncbi Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology and G Monasterio Foundation CNR Regione Toscana, Via Giuseppe Moruzzi 1, Pisa, Italy
    Peptides 30:1710-3. 2009
    ..Higher BNP mRNA expression in the PS is consistent with a reduction in contractile function in this region, while higher CNP mRNA expression in the OS suggests the presence of concomitant endothelial dysfunction in the remote region...
  12. pmc A uroguanylin-GUCY2C endocrine axis regulates feeding in mice
    Michael A Valentino
    Department of Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:3578-88. 2011
    ..Moreover, the uroguanylin-GUCY2C endocrine axis may provide a therapeutic target to control appetite, obesity, and metabolic syndrome...
  13. ncbi Control of lipolysis by natriuretic peptides and cyclic GMP
    Max Lafontan
    Inserm Institut National de la Santé et de la Recherche Médicale U858, I2MR Institut de Médecine Moléculaire de Rangueil, BP 84225, Toulouse Cedex 4, France
    Trends Endocrinol Metab 19:130-7. 2008
    ..We have shown that atrial- and B-type natriuretic peptides (ANP and BNP respectively) stimulate lipolysis in human fat cells through a cGMP-dependent protein kinase (..
  14. pmc Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity
    Kazutoshi Miyashita
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Diabetes 58:2880-92. 2009
    b>Natriuretic peptides (NPs) have been characterized as vascular hormones that regulate vascular tone via guanylyl cyclase (GC), cyclic GMP (cGMP), and cGMP-dependent protein kinase (cGK)...
  15. ncbi Vascular actions of natriuretic peptides. Cyclic GMP-dependent and -independent mechanisms
    Amrita Ahluwalia
    William Harvey Research Institute, St Bart s and The Royal London, Charterhouse Square, EC1M 6BQ London, UK
    Basic Res Cardiol 99:83-9. 2004
    b>Natriuretic peptides play important roles in the regulation of cardiovascular homeostasis...
  16. ncbi Renin-angiotensin system, natriuretic peptides, obesity, metabolic syndrome, and hypertension: an integrated view in humans
    Riccardo Sarzani
    Department of Internal Medicine, Centre for Atherosclerosis and Metabolic Syndrome Hypertension Excellence Centre of the European Society of Hypertension, University of Ancona Politecnica delle Marche, Ancona, Italy
    J Hypertens 26:831-43. 2008
    ..In obesity, lower plasmatic natriuretic peptides levels with increasing BMI, waist circumference, and metabolic syndrome have been documented...
  17. ncbi Biology of natriuretic peptides and their receptors
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Peptides 26:901-32. 2005
    Increasing evidence suggests that natriuretic peptides (NPs) play diverse roles in mammals, including renal hemodynamics, neuroendocrine, and cardiovascular functions...
  18. ncbi The role of natriuretic peptides in cardioprotection
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Cardiovasc Res 69:318-28. 2006
    ..Recent studies also suggest that the intracardiac natriuretic peptides/cGMP system plays a counter-regulatory role against the intracardiac renin-angiotensin-aldosterone system ..
  19. ncbi Cardiac natriuretic peptides: from basic discovery to clinical practice
    Salim Hayek
    Laboratory of Cardiac Growth and Differentiation, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
    Cardiovasc Ther 29:362-76. 2011
    Discoveries of the cardiac natriuretic peptides ANP, BNP, and CNP along with studies of their function and regulation in health and disease, have led to breakthroughs in the understanding and clinical management of heart failure...
  20. ncbi Cardiac hormones as diagnostic tools in heart failure
    Heikki Ruskoaho
    Department of Pharmacology and Toxicology, Biocenter Oulu, FIN 90014 University of Oulu, Finland
    Endocr Rev 24:341-56. 2003
    ....
  21. ncbi Natriuretic peptides: markers or modulators of cardiac hypertrophy?
    David G Gardner
    Department of Medicine and Diabetes Center, University of California at San Francisco, San Francisco, CA 94143 0540, USA
    Trends Endocrinol Metab 14:411-6. 2003
    The natriuretic peptides (NPs), through their diuretic, vasodilatory and anti-mitogenic properties, play an important role in the regulation of cardiovascular, renal and endocrine homeostasis...
  22. pmc Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C
    Hila Romi
    The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev, Ben Gurion University, Beer Sheva 84105, Israel
    Am J Hum Genet 90:893-9. 2012
    ..Because GUCY2C heterozygous and homozygous mutant mice are resistant to E. coli STa enterotoxin-induced diarrhea, it is plausible that GUCY2C mutations in the desert-dwelling Bedouin kindred are of selective advantage...
  23. ncbi Natriuretic peptides and cGMP signaling control of energy homeostasis
    Cedric Moro
    Institut National de la Santé et de la Recherche Médicale UPS UMR 1048 I2MC Institute of Metabolic and Cardiovascular Diseases, Toulouse, France
    Am J Physiol Heart Circ Physiol 304:H358-68. 2013
    Since the discovery of natriuretic peptides (NPs) by de Bold et al...
  24. pmc Influence of sex and hormone status on circulating natriuretic peptides
    Carolyn S P Lam
    Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 58:618-26. 2011
    ..The aim of this study was to assess the relationship between sex hormones and natriuretic peptide levels in community-based adults...
  25. ncbi Effects of estrogen replacement therapy on natriuretic peptides and blood pressure
    Anna H Karjalainen
    Department of Internal Medicine, Biocenter Oulu, University of Oulu, P O Box 20, 90029 OYS, Oulu, Finland
    Maturitas 47:201-8. 2004
    Estrogen replacement therapy (ERT) has been reported to affect blood pressure. Since natriuretic peptides have natriuretic and vasodilatory activity and also inhibit the renin-angiotensin-aldosterone system and lower blood pressure, it ..
  26. ncbi Biology of the natriuretic peptides
    Abelardo Martinez-Rumayor
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Cardiol 101:3-8. 2008
    ....
  27. ncbi Natriuretic peptides and cardiovascular damage in the metabolic syndrome: molecular mechanisms and clinical implications
    Carmine Savoia
    Cardiology Unit, Second Faculty of Medicine, Sant Andrea Hospital, Sapienza University of Rome, Rome, Italy
    Clin Sci (Lond) 118:231-40. 2010
    b>Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator, diuretic and ..
  28. ncbi Natriuretic peptides in unstable coronary artery disease
    Tomas Jernberg
    Department of Medical Sciences, Cardiology and Uppsala Research Center, Sweden
    Eur Heart J 25:1486-93. 2004
    ..This review focuses on the emerging role of natriuretic peptides in the early assessment of patients with unstable CAD...
  29. ncbi Natriuretic peptides and right atrial fibrosis in patients with paroxysmal versus persistent atrial fibrillation
    Hailong Cao
    Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, Jiangsu Province 210029, China
    Peptides 31:1531-9. 2010
    b>Natriuretic peptides (NPs) are excellent diagnostic and prognostic markers of heart failure, but their roles in atrial fibrillation (AF), particularly of isolated cardiac valvular origin, are unclear...
  30. ncbi Natriuretic peptides in the diagnosis and management of acute heart failure
    Asim A Mohammed
    Harvard Medical School, Boston, MA, USA
    Heart Fail Clin 5:489-500. 2009
    ..This article reviews the understanding of utilizing natriuretic peptide testing to correctly diagnose and manage acute heart failure...
  31. pmc Novel bifunctional natriuretic peptides as potential therapeutics
    Deborah M Dickey
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 283:35003-9. 2008
    ..However, none of the chimeric peptides bound NPR-C with significantly higher affinity than endogenous ligands. We suggest that bifunctional chimeric peptides represent a new generation of natriuretic peptide therapeutics...
  32. ncbi Natriuretic peptides in systemic sclerosis-related pulmonary arterial hypertension
    Theodoros Dimitroulas
    Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece
    Semin Arthritis Rheum 39:278-84. 2010
    ..b>Natriuretic peptides (NP) are clinically useful markers of right ventricular dysfunction and pulmonary hypertension...
  33. pmc Natriuretic peptides for the detection of paroxysmal atrial fibrillation in patients with cerebral ischemia--the Find-AF study
    Rolf Wachter
    Department of Cardiology and Pneumology, University of Gottingen, Gottingen, Germany
    PLoS ONE 7:e34351. 2012
    ..We aimed to evaluate prospectively whether natriuretic peptide levels and kinetics identify patients with paroxysmal AF...
  34. pmc Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study
    James L Januzzi
    Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Crit Care 10:R37. 2006
    ..Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful in evaluating heart failure, but its role in evaluating patients with shock in the intensive care unit (ICU) is not clear...
  35. pmc Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction
    Claus Luers
    Department of Cardiology and Pneumology, University of Goettingen, Germany
    Clin Res Cardiol 99:217-26. 2010
    The diagnostic value of natriuretic peptides in asymptomatic patients at risk for diastolic or systolic HF is controversial...
  36. ncbi Natriuretic peptides: linking heart and adipose tissue in obesity and related conditions--a systematic review
    A M R Beleigoli
    Department of Clinical Medicine, Medical School, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Obes Rev 10:617-26. 2009
    The objective of this study was to investigate the association between natriuretic peptides, obesity and related comorbidities...
  37. pmc Natriuretic peptides in the diagnosis and management of chronic heart failure
    Guido Boerrigter
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Heart Fail Clin 5:501-14. 2009
    ..Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases BNP levels) may help to further refine the use of components of the BNP system as biomarkers...
  38. ncbi Natriuretic peptides in vascular physiology and pathology
    Geoffrey E Woodard
    National Institute of Allergy and Infectious Diseases, MSC 1876, Bethesda, Maryland 20892 1876, USA
    Int Rev Cell Mol Biol 268:59-93. 2008
    Four major natriuretic peptides have been isolated: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and Dendroaspis-type natriuretic peptide (DNP)...
  39. ncbi Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular diseases
    Speranza Rubattu
    Department of Cardiology, II School of Medicine, University La Sapienza, Ospedale Sant Andrea, Rome, Italy
    Am J Hypertens 21:733-41. 2008
    ..This review deals with the major relevant findings related to the cardiovascular and metabolic effects of natriuretic peptides, to their potential therapeutic use, and to their role in mediating cardiovascular diseases.
  40. pmc Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy
    Jolanta Gutkowska
    Laboratory of Cardiovascular Biochemistry, Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
    J Physiol 587:4725-36. 2009
    ..Recent studies showed a cardioprotective role of oxytocin (OT) to induce natriuretic peptides (NPs) and nitric oxide (NO) release...
  41. ncbi Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids
    Liam St Pierre
    The Queensland Institute of Medical Research, Brisbane, Australia
    Biochimie 88:1923-31. 2006
    ..Included in these toxin families are the recently described venom natriuretic peptides, which display similar structure and vasoactive functions to mammalian natriuretic peptides...
  42. ncbi Novel natriuretic peptides from the venom of the inland taipan (Oxyuranus microlepidotus): isolation, chemical and biological characterisation
    Bryan G Fry
    Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
    Biochem Biophys Res Commun 327:1011-5. 2005
    ..Thus, these naturally occurring isoforms provide a new platform for further investigation of structure-function relationships of natriuretic peptides.
  43. ncbi Neurohormonal activation in ischemic stroke: effects of acute phase disturbances on long-term mortality
    Mäkikallio Anne
    The Graduate School of Circumpolar Wellbeing, Health and Adaptation, Centre for Arctic Medicine, University of Oulu, Finland
    Curr Neurovasc Res 4:170-5. 2007
    ..The plasma levels of natriuretic peptides are known to be elevated after ischemic stroke, but the relations of these neurohormonal systems in the ..
  44. ncbi Natriuretic peptides and hemodynamics in preeclampsia
    Kati M Tihtonen
    Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland
    Am J Obstet Gynecol 196:328.e1-7. 2007
    The purpose of this study was to evaluate the relationship between natriuretic peptides (NT-proANP and NT-proBNP) and hemodynamic parameters in preeclampsia.
  45. ncbi Plant natriuretic peptides are apoplastic and paracrine stress response molecules
    Yu Hua Wang
    Monash Institute of Pharmaceutical Sciences, Monash University 381 Royal Parade, Parkville, VIC 3052, Australia
    Plant Cell Physiol 52:837-50. 2011
    ....
  46. ncbi Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure
    Osamu Tsukamoto
    Cardiovascular Division of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Coll Cardiol 53:2070-7. 2009
    We investigated the functional relationship between natriuretic peptides and adiponectin by performing both experimental and clinical studies.
  47. pmc Interpretation and use of natriuretic peptides in non-congestive heart failure settings
    Shih Hung Tsai
    Department of Emergency Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Yonsei Med J 51:151-63. 2010
    b>Natriuretic peptides (NPs) have been found to be useful markers in differentiating acute dyspneic patients presenting to the emergency department (ED) and emerged as potent prognostic markers for patients with congestive heart failure (..
  48. ncbi Biosynthesis of cardiac natriuretic peptides
    Jens Peter Goetze
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, 2100, Copenhagen, Denmark
    Results Probl Cell Differ 50:97-120. 2010
    ..An astonishing amount of clinical studies have established cardiac natriuretic peptides and their molecular precursors as useful markers of heart disease...
  49. ncbi Novel natriuretic peptides: new compounds and new approaches
    Mark W Vogel
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Curr Heart Fail Rep 8:22-7. 2011
    The natriuretic peptides (NPs) are a group of structurally similar yet genetically distinct peptides that have diverse actions in cardiovascular, renal, and endocrine homeostasis...
  50. ncbi Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a 'whip-brake' system of the endocrine heart
    Bruno Tota
    Department of Cell Biology, University of Calabria, 87030, Arcavacata di Rende, Italy
    J Exp Biol 213:3081-103. 2010
    ..the search for the intrinsic endocrine heart properties, culminating in 1981 with the discovery of the natriuretic peptides (NP)...
  51. pmc Natriuretic peptides and the genomics of left-ventricular hypertrophy
    Daniel L Dries
    Penn Cardiovascular Institute and Cardiovascular Division, Heart Failure and Transplant Group, Heart Vascular Center, 3400 Civic Center Boulevard, Philadelphia, PA 19104 4283, USA
    Heart Fail Clin 6:55-64. 2010
    ..It promises the opportunity to identify high-risk individuals for targeted intervention and may identify novel therapeutic targets for improved prevention and treatment strategies...
  52. ncbi Ventricular function and natriuretic peptides in sequentially combined models of hypertension
    Susana Cavallero
    Department of Pathophysiology, Institute of Pathophysiology and Clinical Biochemistry, University of Buenos Aires, Argentina
    Am J Physiol Heart Circ Physiol 298:H1290-9. 2010
    ..in vivo cardiac function, interstitial fibrosis, and synthesis and secretion of types A (ANP) and B (BNP) natriuretic peptides were monitored in hypertensive models compared with their corresponding sham (Sh2, Sh4)...
  53. ncbi Serum levels of natriuretic peptides in patients with Behcet's disease
    Ramazan Yagci
    Department of Ophthalmology, Fatih University, Medical School, Ankara, Turkey
    Clin Rheumatol 27:1153-8. 2008
    ..4 +/- 6.1 years; seven men and 19 women) matched for age and gender from a similar ethnic background. Serum natriuretic peptides levels were determined by enzyme immunoassay kit. Mean serum ANP concentrations in the active patients (4...
  54. ncbi Natriuretic peptides and filling pressure at rest and stress
    Manish Bansal
    University of Queensland, Brisbane, Australia
    Heart Fail Clin 4:71-86. 2008
    The natriuretic peptides are a family of compounds secreted from the atria and ventricles in response to a variety of stimuli, including increased wall stress, tachycardia, and myocardial ischemia...
  55. pmc Role of natriuretic peptides in the diagnosis and treatment of patients with carcinoid heart disease
    J M Zuetenhorst
    Department of Gastroenterology, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Br J Cancer 90:2073-9. 2004
    ..We evaluated whether natriuretic peptides (ANP or NT-proBNP) are useful in early detection of CHD...
  56. ncbi Natriuretic peptides in hormonal regulation of hypoxia responses
    Olli Arjamaa
    Centre of Excellence in Evolutionary Genetics and Physiology, Department of Biology, University of Turku, FI 20014 Turku, Finland
    Am J Physiol Regul Integr Comp Physiol 296:R257-64. 2009
    The possibility that natriuretic peptides' effects are important in hypoxia responses of vertebrates is reviewed. Both the transcription and release of natriuretic peptides are affected by oxygen tension...
  57. ncbi The natriuretic peptides as biomarkers for adults with congenital heart disease
    Amiram Nir
    Department of Pediatric Cardiology, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem 91120, Israel
    Biomark Med 6:827-37. 2012
    ..The natriuretic peptides are important markers for the presence, severity and prognosis of heart disease...
  58. pmc Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis
    M P Garin-Laflam
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, and University of Cincinnati, MLC 2010, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Gastrointest Liver Physiol 296:G740-9. 2009
    ..These in vivo findings demonstrate increased radiosensitivity of IECs in UGN and GC-C KO mice and a role for cGMP as a primary downstream mediator of GC-C activation in the protection of these IECs from radiation-induced apoptosis...
  59. ncbi Coordinate upregulation of guanylin and uroguanylin expression by hypertonicity in HT29-18-N2 cells
    Kris A Steinbrecher
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Hospital Research Foundation, Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio 45229, USA
    Am J Physiol Cell Physiol 283:C1729-37. 2002
    ..We conclude that guanylin and uroguanylin are released in response to hypertonic stress and that regulation of these genes may be mediated by PKC isoforms...
  60. ncbi Clinical utility of natriuretic peptides in dialysis patients
    Angela Yee Moon Wang
    Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Semin Dial 25:326-33. 2012
    ..The natriuretic peptides, namely brain natriuretic peptide (BNP) or N-terminal pro-brain natriuretic peptide (NT-pro-BNP), belong to ..
  61. ncbi Natriuretic peptides differentially attenuate thrombin-induced barrier dysfunction in pulmonary microvascular endothelial cells
    James R Klinger
    Pulmonary Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Department of Medicine, Brown Medical School, Research Services, Providence, RI 02908, USA
    Exp Cell Res 312:401-10. 2006
    ..In the current study, we assessed the effects of the three natriuretic peptides on thrombin-induced barrier dysfunction in rat lung microvascular endothelial cells (LMVEC)...
  62. ncbi Natriuretic peptides in ESRD
    Sergei Joffy
    Department of Internal Medicine and Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22903, USA
    Am J Kidney Dis 46:1-10. 2005
    b>Natriuretic peptides are involved in the regulation of volume homeostasis...
  63. ncbi Laboratory parameters of cardiac and kidney dysfunction in cardio-renal syndromes
    Dinna N Cruz
    Department of Nephrology, San Bortolo Hospital, Vicenza, Italy
    Heart Fail Rev 16:545-51. 2011
    ..b>Natriuretic peptides (NPs) have been validated as an important cardiac biomarker for risk stratification and prognostication in ..
  64. ncbi Icodextrin increases natriuretic peptides in diabetic patients undergoing CAPD
    Ryotaro Bouchi
    Division of Nephrology and Hypertension Department of Medicine Diabetes Center Tokyo Women s Medical University School of Medicine Tokyo, Japan
    Perit Dial Int 26:604-7. 2006
  65. ncbi Molecular mechanisms underlying cardiac antihypertrophic and antifibrotic effects of natriuretic peptides
    Camilla Calvieri
    Cardiology, Department of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S Andrea, Rome, Italy
    J Mol Med (Berl) 90:5-13. 2012
    b>Natriuretic peptides (NPs) exert well-characterized protective effects on the cardiovascular system, such as vasorelaxation, natri- and diuresis, increase of endothelial permeability, and inhibition of renin-angiotensin-aldosterone system...
  66. ncbi Role of the natriuretic peptide system in lipogenesis/lipolysis
    P Dessi-Fulgheri
    Clinica di Medicina Interna, Azienda Ospedaliera Umberto I, Via Conca, 60020 Ancona, Italy
    Nutr Metab Cardiovasc Dis 13:244-9. 2003
    ..This effect is mediated by the interaction of NP with its active receptors through guanylyl cyclase activation and cGMP production. This review will briefly focus on the new aspects of NP pathophysiology in man...
  67. ncbi Natriuretic peptides as markers of preclinical cardiac disease in obesity
    A M Grandi
    University of Insubria, Varese, Italy
    Eur J Clin Invest 34:342-8. 2004
    Aim of the study was to evaluate the role of atrial (ANP) and brain natriuretic peptides (BNP) as markers of preclinical cardiac disease in obesity.
  68. ncbi Natriuretic peptides in the regulation of the hypothalamic-pituitary-adrenal axis
    Andrea Porzionato
    Department of Human Anatomy and Physiology, University of Padova, Padova, Italy
    Int Rev Cell Mol Biol 280:1-39. 2010
    Atrial (ANP), brain (BNP), and C-type (CNP) natriuretic peptides act by binding to three main subtypes of receptors, named NPR-A, -B, and -C. NPR-A and NPR-B are coupled with guanylate cyclase...
  69. ncbi Natriuretic peptides in therapy for decompensated heart failure
    Natig Gassanov
    Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Eur J Clin Pharmacol 68:223-30. 2012
    ..b>Natriuretic peptides provide a promising mechanism of action in the pathophysiologic background for CHF treatment based on their ..
  70. ncbi Natriuretic peptides in heart failure: where we are, where we are going
    Alberto Palazzuoli
    Department of Internal Medicine and Metabolic Diseases, S Maria alle Scotte Hospital, University of Siena, Siena, Italy
    Intern Emerg Med 6:63-8. 2011
    ..The discovery of natriuretic peptides (BNP) as diagnostic biomarkers has been one of the most critical advances for heart failure diagnosis...
  71. ncbi Natriuretic peptides: biochemical markers of anthracycline cardiac toxicity?
    D Urbanova
    Institute of Pathophysiology, Comenius University Medical School, Bratislava, Slovakia
    Oncol Res 17:51-8. 2008
    ..The role of routinely used cardiomarkers is controversial and limited in this setting. Natriuretic peptides have shown promising results in assessment and monitoring of both acute and late clinical and subclinical ..
  72. ncbi Gene expression, processing, and secretion of natriuretic peptides: physiologic and diagnostic implications
    Hugo Ramos
    Hospital de Urgencias, National University of Cordoba, Cordoba, Argentina
    Heart Fail Clin 2:255-68. 2006
  73. ncbi Biomarker guided therapy for heart failure: focus on natriuretic peptides
    Kirkwood F Adams
    Department of Medicine, School of Medicine, UNC Heart Failure Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    Heart Fail Rev 15:351-70. 2010
    ..Emerging results suggest that guiding therapy based on serial changes in natriuretic peptides may be an effective strategy...
  74. pmc An unsuspected property of natriuretic peptides: promotion of calcium-dependent catecholamine release via protein kinase G-mediated phosphodiesterase type 3 inhibition
    Noel Yan Ki Chan
    Dept of Pharmacology, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065 4896, USA
    Circulation 125:298-307. 2012
    Although natriuretic peptides are considered cardioprotective, clinical heart failure trials with recombinant brain natriuretic peptide (nesiritide) failed to prove it...
  75. ncbi Natriuretic peptides and their receptors in the central nervous system
    Li Hui Cao
    Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
    Prog Neurobiol 84:234-48. 2008
    b>Natriuretic peptides (NPs), including atrial, brain and C-type NPs, are a family of structurally related but genetically distinct peptides...
  76. ncbi Natriuretic peptides as predictors of non-sudden and sudden cardiac death after acute myocardial infarction in the beta-blocking era
    Jari M Tapanainen
    Division of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu, Finland
    J Am Coll Cardiol 43:757-63. 2004
    This prospective study tested whether the natriuretic peptides predict cardiac death among patients using beta-blocking therapy after an acute myocardial infarction (AMI).
  77. ncbi Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation
    M William
    Northern Cardiac Research Group, Kolling Institute, University of Sydney, Sydney, Australia
    Am J Physiol Cell Physiol 294:C1067-73. 2008
    b>Natriuretic peptides (NPs) and their receptors (NPRs) are expressed in the heart, but their effects on myocyte function are poorly understood...
  78. pmc Genetic variation in the natriuretic peptide system and heart failure
    David E Lanfear
    Henry Ford Heart and Vascular Institute, Section of Advanced Heart Failure and Cardiac Transplantation, Henry Ford Hospital, 2799 W Grand Boulevard, K14, Detroit, MI 48202, USA
    Heart Fail Rev 15:219-28. 2010
    ..and BNP (nesiritide) and are approved HF therapies in Japan and the US, respectively and additional natriuretic peptides (e.g., CNP, urodilatin, and designer NPs) are under investigation for use in HF...
  79. ncbi The evolution of the natriuretic peptides - Current applications in human and animal medicine
    Roland R J van Kimmenade
    Cardiology Division and Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Yawkey, Boston, MA 5984, USA
    J Vet Cardiol 11:S9-21. 2009
    Although natriuretic peptides have played an important role in the fluid homeostasis of vertebrates for over several million years, their importance has only been noticed in the last few decades...
  80. ncbi Natriuretic peptides as markers of mild forms of left ventricular dysfunction: effects of assays on diagnostic performance of markers
    Angelika Hammerer-Lercher
    Department of Medical Chemistry and Biochemistry, Division of Clinical Biochemistry, Innsbruck Medical University, Innsbruck, Austria
    Clin Chem 50:1174-83. 2004
    We compared the performance of different natriuretic peptides to diagnose mild forms of left ventricular dysfunction (LVD) and investigated the influence of measuring B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) with ..
  81. ncbi Natriuretic peptides - physiology, pathophysiology and clinical use in heart failure
    J Krupicka
    Third Department of Internal Medicine, General University Hospital in Prague, Prague, Czech Republic
    Physiol Res 58:171-7. 2009
    The natriuretic peptides - atrial, brain and C-type - were discovered during the last twenty years. Their effects on cardiovascular, renal, cerebral and other tissues through guanylyl cyclase were uncovered...
  82. ncbi Natriuretic peptides as regulators of myocardial structure and function: pathophysiologic and therapeutic implications
    Alessandro Cataliotti
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55904, USA
    Heart Fail Clin 2:269-76. 2006
  83. ncbi Molecular cloning of natriuretic peptides from the heart of reptiles: loss of ANP in diapsid reptiles and birds
    Sofie Trajanovska
    School of Life and Environmental Sciences, Deakin University, Geelong, Vic, Australia
    Gen Comp Endocrinol 156:339-46. 2008
    ..This data provides new avenues for research on NP function in reptiles...
  84. ncbi Natriuretic peptides in cardiovascular diseases of fetus, infants and children
    Bibhuti B Das
    Division of Cardiology, Department of Pediatrics, University of Louisville, 571 S Floyd Street, Louisville, KY 40202, USA
    Cardiovasc Hematol Agents Med Chem 7:43-51. 2009
    The natriuretic peptides (NP) appear to be functional by midgestation, respond to volume stimuli, and regulate blood pressure and salt and water balance in the developing embryo...
  85. ncbi Lipid mobilization in subcutaneous adipose tissue during exercise in lean and obese humans. Roles of insulin and natriuretic peptides
    Katrien Koppo
    Department of Sports Medicine, Third Faculty of Medicine, Charles University of Prague, Ruska 87, Prague 10, Czech Republic
    Am J Physiol Endocrinol Metab 299:E258-65. 2010
    ..The octreotide-induced enhancement of exercise lipolysis in lean subjects was associated with an increased exercise-induced plasma NP response. Adenosine may contribute to the inhibition of basal lipolysis in both subject groups...
  86. pmc Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments
    Leslie A Piggott
    Program in Cell and Regulatory Biology, The University of Texas Graduate School of Biomedical Sciences at Houston, 77225, USA
    J Gen Physiol 128:3-14. 2006
    ..These results suggest that cGMP signals are spatially segregated within cells, and that the functional compartmentalization of cGMP signals may underlie the unique actions of ANP and nitric oxide...
  87. ncbi Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac troponins and natriuretic peptides
    Micha Maeder
    Division of Cardiology, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 129:1349-66. 2006
    ..Cardiac troponins and natriuretic peptides are biomarkers that were previously introduced for diagnosis and risk stratification in patients with acute ..
  88. ncbi Hypoxia inducible factor-1 improves the actions of nitric oxide and natriuretic peptides after simulated ischemia-reperfusion
    Jason A Luciano
    Heart and Brain Circulation Laboratory, Department of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, NJ 08854 5635, USA
    Cell Physiol Biochem 21:421-8. 2008
    ..Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion...
  89. ncbi Natriuretic peptides in patients with atrial fibrillation
    Beata Wożakowska-Kapłon
    Department of Cardiology Regional District Hospital, Institute for Medical Education, University of Kielce, Poland
    Cardiol J 15:525-9. 2008
    The aim of the study was to evaluate plasma natriuretic peptides (NPs): atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations in patients with paroxysmal, persistent and permanent atrial fibrillation (AF).
  90. ncbi Coronary flow reserve in idiopathic dilated cardiomyopathy: relation with left ventricular wall stress, natriuretic peptides, and endothelial dysfunction
    Frank Lloyd Dini
    Unità Malattie Cardiovascolari 2, Santa Chiara Hospital, Pisa, Italy
    J Am Soc Echocardiogr 22:354-60. 2009
    ....
  91. ncbi Natriuretic peptides and the dialysis patient
    Mathavakkannan Suresh
    Renal Unit, Lister Hospital, Stevenage, Herts, United Kingdom
    Semin Dial 18:409-19. 2005
    ..b>Natriuretic peptides have been extensively investigated as biochemical markers of the fluid state...
  92. ncbi Differential diagnosis of acute dyspnea: the value of B natriuretic peptides in the emergency department
    P Ray
    Service d accueil des urgences, Groupe Hospitalier Pitie Salpetriere, Paris, France
    QJM 101:831-43. 2008
    ..The purpose of this review is to indicate recent developments in biomarkers of heart failure and to evaluate their impact on clinical use in the emergency setting...
  93. ncbi Cardiovascular disease in patients with chronic renal impairment: role of natriuretic peptides
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouwe Ziekenhuis, Aalst, Belgium
    Congest Heart Fail 14:38-42. 2008
    Although there is overwhelming evidence that natriuretic peptides might be helpful in the diagnosis and management of congestive heart failure patients, the relationship among brain natriuretic peptides (BNP), renal function, and the ..
  94. pmc Xanthomonas axonopodis pv. citri uses a plant natriuretic peptide-like protein to modify host homeostasis
    Natalia Gottig
    Molecular Biology Division, Instituto de Biologia Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Rosario, Argentina
    Proc Natl Acad Sci U S A 105:18631-6. 2008
    Plant natriuretic peptides (PNPs) are a class of extracellular, systemically mobile molecules that elicit a number of plant responses important in homeostasis and growth. The bacterial citrus pathogen, Xanthomonas axonopodis pv...
  95. ncbi Natriuretic peptides in common valvular heart disease
    Christopher D Steadman
    Department of Cardiovascular Sciences, University Hospitals of Leicester, Leicester, UK
    J Am Coll Cardiol 55:2034-48. 2010
    ..In this state-of-the-art review, we examine the current evidence relating to natriuretic peptides as potential biomarkers in aortic stenosis and mitral regurgitation...
  96. ncbi Receptor autoradiography as mean to explore the possible functional relevance of neuropeptides: focus on new agonists and antagonists to study natriuretic peptides, neuropeptide Y and calcitonin gene-related peptides
    Yvan Dumont
    Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 Boul LaSalle, Montreal, Que, Canada H4H 1R3
    Peptides 25:365-91. 2004
    ..We review here tools that are currently available in order to target each NP, NPY and CT/CGRP receptor subtype and establish their respective pathophysiological relevance...
  97. ncbi The natriuretic peptides and their role in disorders of right heart dysfunction and pulmonary hypertension
    Lok B Yap
    Department of Cardiology, Homerton University Hospital NHS Trust, London, E9 6SR, UK
    Clin Biochem 37:847-56. 2004
    ..The general physiological and potential therapeutic roles of natriuretic peptides in respiratory disease, right ventricular (RV) dysfunction, and pulmonary arterial hypertension (PAH) are ..
  98. ncbi The effect of altering haemodynamics on the plasma concentrations of natriuretic peptides in heart failure
    A I Larsen
    University of Bergen, Cardiology Division, Stavanger University Hospital, N 4001 Stavanger, Norway
    Eur J Heart Fail 8:628-33. 2006
    ....
  99. ncbi In vitro expression of natriuretic peptides in cardiomyocytes differentiated from monkey embryonic stem cells
    Essam Mohamed Abdelalim
    Research Center for Animal Life Science, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Biochem Biophys Res Commun 340:689-95. 2006
    ..One of the crucial functions of cardiomyocytes is a production of atrial and brain natriuretic peptides (ANP and BNP, respectively), which have important endocrine, autocrine, and paracrine functions...
  100. ncbi The influence of percutaneous closure of patent ductus arteriosus on left ventricular size and function: a prospective study using two- and three-dimensional echocardiography and measurements of serum natriuretic peptides
    Anneli Eerola
    Department of Pediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    J Am Coll Cardiol 47:1060-6. 2006
    ..We aimed to evaluate the effect of percutaneous closure of patent ductus arteriosus (PDA) on left ventricular (LV) hemodynamics...
  101. ncbi In vitro effects of homologous natriuretic peptides on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus
    Bradley K Fox
    Hawaii Institute of Marine Biology, University of Hawaii, P O Box 1346, Kaneohe, HI 96744, USA
    Gen Comp Endocrinol 150:270-7. 2007
    ..mature sequence was chemically synthesized together with previously cloned tilapia A-type and B-type natriuretic peptides (ANP and BNP). The cloned CNP belongs to the CNP-1 type of teleosts...

Research Grants64

  1. EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    David Gardner; Fiscal Year: 2002
    The natriuretic peptides are a family of gene products which display potent vasorelaxant and volume-contracting activity in a number of different species, including humans...
  2. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..in important mediators of pulmonary transition at birth such as nitric oxide, beta adrenergic agents, natriuretic peptides and prostaglandins secondary to antenatal glucocorticoid use...
  3. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..The work described in this proposal focuses on elucidating mechanisms to support the use of caveolin proteins as novel therapeutic targets for heart failure patients and is of relevance to the VA patient care mission. ..
  4. ANP Receptor: Molecular approach of signaling mechanisms
    Kailash N Pandey; Fiscal Year: 2013
    ..mechanisms of pathogenesis whereby malregulation of receptor-mediated cardiac hormones;atrial and brain natriuretic peptides (ANP, BNP) bioactivity could result in abnormalities of fluid volume regulation and blood pressure ..
  5. Regulation of guanylyl cyclase A and B by hormones, ATP and phosphorylation
    Lincoln Ross Potter; Fiscal Year: 2013
    ..receptors are highly phosphorylated in resting cells and dephosphorylated receptors are unresponsive to natriuretic peptides (NPs)...
  6. Histamine Receptor Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2013
    ..consequences;and, 2) The inhibition of a previously unsuspected pro-adrenergic effect of cardiac natriuretic peptides. An in- depth exploration of these novel H3-receptor-mediated cardioprotective effects is the main goal of ..
  7. Regulation and function of cGMP dependent protein kinase in cardiac hypertrophy
    Eiki Takimoto; Fiscal Year: 2013
    ..Accumulating evidence shows that enhanced synthesis of cGMP by nitric oxide or natriuretic peptides negatively regulate cardiac hypertrophy development...
  8. Regulation and Catalysis of Human Insulin Degrading Enzyme
    Wei Jen Tang; Fiscal Year: 2013
    ..the structures of human IDE in complex with insulin, A?, and other functionally relevant substrates such as natriuretic peptides and proinflammatory chemokines, CCL3/CCL4...
  9. Risk prediction of atrial fibrillation: clinical, biological and genetic markers
    EMELIA J contact BENJAMIN; Fiscal Year: 2010
    ..To test whether biomarkers, specifically natriuretic peptides or C-reactive protein enhance risk prediction (discrimination, calibration, reclassification) of AF when ..
  10. Role of natriuretic peptides in the ductus arteriosus
    JOHN JEFFREY REESE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Natriuretic peptides (NPs) regulate blood pressure and fluid balance via their diuretic, natriuretic, and vasoactive properties, and are biomarkers of heart failure in adults and children...
  11. Particle-Induced Cardiac Effects in Senescent Mice
    Clarke Tankersley; Fiscal Year: 2009
    ..The protection afforded by natriuretic peptides wanes with age leaving the pulmonary vasculature and right ventricle susceptible PM exposure leading to ..
  12. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..NEP degrades natriuretic peptides as well as neuropeptides such as calcitonin gene-related peptide (CGRP) and bradykinin...
  13. Genetic Determinants of Hypertensive Heart Disease in CRI
    Daniel L Dries; Fiscal Year: 2011
    ..The NPS describes the ability of the heart to synthesis and release of natriuretic peptides (atrial natriuretic peptide [ANP], brain natriuretic peptide [BNP], and C-type natriuretic peptide [CNP]) ..
  14. Transduction mechanisms and CNS targets of GC-D neurons
    Steven D Munger; Fiscal Year: 2013
    ..abstract_text> ..
  15. PKG Redox Modulation of Cardiac Function and Disease
    DAVID ALAN KASS; Fiscal Year: 2013
    ..This indicates that therapies leveraging PKG activation, such as natriuretic peptides, nitric oxide donors, or PDE5-inhibitors, may themselves critically depend on PKG redox state...
  16. Anthraycline-related cardiotoxicity in long-term survivors of lymphoma
    SARO ARMENIAN; Fiscal Year: 2013
    ..echocardiography], 2D- M-mode derived diastolic and systolic indices) and blood (cardiac troponins, natriuretic peptides, Galectin-3, ST-2, metabolomics) indices in detecting LV dysfunction (abnormal ESWS) in adult lymphoma ..
  17. TRANSPORT ACROSS CAPILLARY ENDOTHELIUM
    Fitz Roy E Curry; Fiscal Year: 2013
    ..The overall aim of this research is to investigate the role of the circulating hormones known as Natriuretic Peptides (NPs) as endogenous anti-inflammatory agents that reduce vascular hyperpermeability in intact microvessels ..
  18. Cardiovascular Peptides and Myocardial Infarction
    Horng H Chen; Fiscal Year: 2013
    ..Our proposal represents an advanced therapeutic strategy designed to go beyond native natriuretic peptides (NPs) with the use of the first dual GC receptor chimeric NP (GC-B>GC-A affinity) that combines key ..
  19. Corin in Cardiomyopathy and Heart Failure
    Inna P Gladysheva; Fiscal Year: 2013
    ..Aim 1 we seek to determine how sex, age and cardiomyopathy affect the expression and activity of the corin-natriuretic peptides system...
  20. Obesity, salt-sensitivity, and the natriuretic peptides
    Thomas J Wang; Fiscal Year: 2013
    ....
  21. Biology and Novel Therapeutics of Cardiovascular Peptides
    John C Burnett; Fiscal Year: 2013
    ..our efforts to translate the biology of the endogenous particulate guanylyl cyclase (GC) activators, the natriuretic peptides (NPs), into novel therapeutics for human cardiorenal disease highly relevant to heart failure and ..
  22. ACTIONS OF CYCLIC GMP IN SMOOTH MUSCLE
    Thomas Lincoln; Fiscal Year: 1999
    Cyclic GMP mediates vascular smooth muscle relaxation to nitric oxide and atrial natriuretic peptides. Endogenous vascular tone, tissue perfusion, and the growth and differentiation state of vascular smooth muscle are all regulated by ..
  23. Novel Markers of Anthracycline-induced Myocardial Damage
    Charles L Shapiro; Fiscal Year: 2011
    ..damage;likewise the results of blood markers to detect early myocardial damage, such as troponins and natriuretic peptides, are conflicting and not routinely used in practice...
  24. GUIDing Evidence Based Therapy Using Biomarker Intensified Treatment (CCC)
    GARY M FELKER; Fiscal Year: 2013
    ..The natriuretic peptides are biomarkers of hemodynamic stress that provide important prognostic information in HF...
  25. CGMP PROTEIN KINASE IN PREGNANT MYOMETRIUM
    Trudy Cornwell; Fiscal Year: 2000
    ..This cyclic nucleotide mediates many effects of nitric oxide and atrial natriuretic peptides by activating the cG-kinase...
  26. Molecular Control of cGMP Signaling by PKGs and PDEs
    Jackie Corbin; Fiscal Year: 2007
    ..nerve depression, and opiod action, cGMP mediates effects of natural signals such as nitric oxide, natriuretic peptides, and guanylins, as well as effects of medications such as nitroglycerin and sildenafil (Viagra/TM)...
  27. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 2001
    ..The natriuretic peptides (NPs) are important in regulating body fluid volume, and in moving fluid between compartments...
  28. ATRIAL PEPTIDE REGULATION OF SODIUM TRANSPORT
    Mark Zeidel; Fiscal Year: 1990
    Atrial natriuretic peptides (ANP) induce large increases in renal sodium excretion. Evidence is accumulating that ANP induces natriuresis in part by directly altering sodium transport in the inner medullary collecting duct (IMCD)...
  29. Identifiction of the natriuretic peptide receptor kinase
    LINCOLN POTTER; Fiscal Year: 2009
    ..Endogenous hormones called natriuretic peptides combat cardiovascular disease...
  30. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2007
    ..This apparent paradox is explained by the important counter-regulatory function of the natriuretic peptides, which are secreted in response to atrial and ventricular wall stress...
  31. Molecular Mechanisms of PDE5 Regulation
    Jackie Corbin; Fiscal Year: 2005
    ..Natural signals (natriuretic peptides, guanylins and nitric oxide), in addition to many medications, stimulate cGMP cascades by activating these ..
  32. CONTROL OF RENAL FUNCTION BY INTRARENAL ANGIOTENSIN
    Robert Carey; Fiscal Year: 1991
    ..Atrial natriuretic peptides, released from cardiac myocytes, have been demonstrated to modulate renal function...
  33. ESCAPE Mechanistic Substudies
    Robert Califf; Fiscal Year: 2003
    ..The first goal wlll be accomplished by evaluating relations between levels of natriuretic peptides, troponins, and clinical outcomes...
  34. REGULATION OF THE ANP RECEPTOR/GUANYLYL CYCLASE
    Michael Chinkers; Fiscal Year: 2000
    ..health relatedness of the project lies in gaining a better understanding of (1) the mechanisms of action of natriuretic peptides that are potential therapeutic agents, and the mechanisms by which responsiveness to these peptides is lost ..
  35. Ventricular Matrix Remodeling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2004
    ..of ECM remodeling and : echocardiographic LVH and LV dilatation; Doppler indices of LV filling; serum natriuretic peptides. 3...
  36. ATRIAL PEPTIDES IN NORMAL AND HYPERTENSIVE PREGNANCY
    Marshall Lindheimer; Fiscal Year: 1990
    ..Finally, this response to the solicited RFA represents an extension of applicants' ongoing research interests that center on the kidney and volume homeostasis in pregnancy...
  37. STICH TRIAL - NEUROHORMONAL/ CYTOKINE/ GENETIC CORE LAB
    Arthur Feldman; Fiscal Year: 2007
    ..neurohormone/cytokine/genetic core will test three hypothesis: 1) pre-operative levels of neurohormones, natriuretic peptides, and pro-inflammatory cytokines will be useful in predicting that group of patients who will most likely ..
  38. MECHANISMS OF NOCTURIA IN OLDER ADULTS
    Mary Umlauf; Fiscal Year: 1999
    ..It is hypothesized that the negative intrathoracic pressure generated during OSA stimulate the release of natriuretic peptides, which increase urine production. She proposes three phases of study to examine this relationship...
  39. Diastolic Function, Stress & Natriuresis in Adults
    Gaston Kapuku; Fiscal Year: 2009
    ..4) Stress-induced sodium excretion will correlate with concomitant stress-induced changes in natriuretic peptides (ANP, BMP)...
  40. ANGIOTENSIN CONVERTING ENZYME
    IRWIN WILSON; Fiscal Year: 1991
    We will continue our studies on the enzymology of certain peptide hormones: Angiotensin I, atrial natriuretic peptides, hypothalmic gonadotropin releasing hormone (GnRH), and GnRH associated peptide (GAP) which may be prolactin releasing ..
  41. GROWTH AND DEATH OF VASCULAR SMOOTH MUSCLE CELLS
    Chiming Wei; Fiscal Year: 2002
    DESCRIPTION (Adapted from Applicant's Abstract): The natriuretic peptides (NPS) include ANP, BNP and CNP. The NPS mediate their actions via generation of the second messenger cGMP following activation of biological receptors...
  42. Neurohormonal Activation in Pulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    ..Studies have documented elevated levels of endothelin, natriuretic peptides, and norepinephine in patients with this disease...
  43. NATRIURETIC PEPTIDES AND THE LUNG
    Nicholas Hill; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract and specific aims): Since the discovery of natriuretic peptides in 1981, a tremendous amount of research has characterized the molecular biology, pharmacology, and physiologic significance of ..
  44. Role of Natriuretic Peptides in the Cochlea
    George Trachte; Fiscal Year: 2004
    ..abstract_text> ..
  45. Inflammation & Prognosis in Decompensated Heart Failure
    GARY FELKER; Fiscal Year: 2008
    ..Felker's development into an established independent clinical investigator with expertise in both complex clinical research methodology and the role of inflammation in the pathophysiology of heart failure. ..
  46. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2005
    ..Hormones that combat these potentially deadly consequences of volume overload are called natriuretic peptides. In response to increased blood pressure, atrial natriuretic peptide (ANP) and brain natriuretic peptide (..
  47. Genetic Determinants of Hypertension, LVH, and CHF
    Daniel Dries; Fiscal Year: 2006
    ..In addition we will analyze the association of these genotypes with prognosis in patients with advanced systolic heart failure. ..
  48. REGULATION OF GENE EXPRESSION BY NO/CGMP
    RENATE PILZ; Fiscal Year: 2002
    ....
  49. Cardiac Troponin Testing for Myocardial Infarction
    Fred Apple; Fiscal Year: 2001
    ..abstract_text> ..
  50. Gene Targeting to Study Light-induced Circadian Changes
    James Waschek; Fiscal Year: 2003
    ..Moreover, the same targeting system should have utility in investigating individual components of the clock, such as PER, CRY, BMAL and CLOCK proteins. ..
  51. PURINERGIC AXIS OF CARDIAC BLOOD VESSELS
    IAIN BUXTON; Fiscal Year: 2001
    ..We will approach these aims with biochemical, pharmacological, molecular, cell biological and microscopic methods employing intact blood vessels, cells in primary culture and subcellular fractions. ..
  52. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..
  53. REGULATION OF ENDOTHELIAL NO SYNTHASE BY PHOSPHORYLATION
    MARSHALL CORSON; Fiscal Year: 2003
    ..To determine the mechanotransducers of fluid shear stress to eNOS phosphorylation. Aim 4. To elucidate the regulatory role of eNOS phosphorylation in regenerating endothelial cells in culture and in denuded rat aorta. ..
  54. REGULATORY RESPONSES TO POSITIVE ENERGY BALANCE
    Randy Seeley; Fiscal Year: 2006
    ..The information from this proposal will be critical to a complete picture of how energy balance is regulated and how disorders of energy balance such as obesity may be treated. ..
  55. Cyclic GMP And Ventricular Function In Heart Failure
    MARGARET REDFIELD; Fiscal Year: 2003
    ..abstract_text> ..
  56. PREDICTORS OF RECURRENT STROKE IN THE PROGRESS STUDY
    Duncan Campbell; Fiscal Year: 2003
    ..In addition, plasma markers that predict risk of recurrent stroke may indicate novel therapies to prevent this condition. ..
  57. Imaging Apoptosis to Detect Unstable Atheromatous Plaque
    Jagat Narula; Fiscal Year: 2004
    ..The impending surgical intervention will allow histopathological evaluation of the endarterectomy specimens to define potential utility of annexin imaging. ..
  58. Genetic Predictors of Outcome in Acute MI
    Marc Sabatine; Fiscal Year: 2005
    ..Genomic control will be employed to detect and control for population stratification. Interaction terms will be incorporated into regression models to explore gene-environment and pharmacogenomic interactions. ..
  59. CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
    Michael Cohen; Fiscal Year: 2006
    ..Finally, I will see if NECA's salvage of myocardium at reperfusion translates into rapid functional benefits. It is hoped that the potential of this new pharmacologic approach can be defined. ..
  60. Informatics Support to Enhance Human Subjects Research
    John Burnett; Fiscal Year: 2003
    ..We also will work with both Olmsted Medical Center and Luther Midelfort in evaluation of standardized procedures. We plan to share our best practices with all three of these institutions at the conclusion of the grant. ..