leptin

Summary

Summary: A 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. Leptin provides the key afferent signal from fat cells in the feedback system that controls body fat stores.

Top Publications

  1. ncbi Effects of the obese gene product on body weight regulation in ob/ob mice
    M A Pelleymounter
    Department of Neurobiology, Amgen, Inc, Thousand Oaks, CA 91320, USA
    Science 269:540-3. 1995
  2. ncbi Weight-reducing effects of the plasma protein encoded by the obese gene
    J L Halaas
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
    Science 269:543-6. 1995
  3. ncbi Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
    L A Campfield
    Department of Metabolic Diseases, Hoffmann La Roche Incorporated, Nutley, NJ 07110, USA
    Science 269:546-9. 1995
  4. ncbi Identification and expression cloning of a leptin receptor, OB-R
    L A Tartaglia
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 83:1263-71. 1995
  5. ncbi Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    H Chen
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 84:491-5. 1996
  6. ncbi Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
  7. ncbi The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 7:941-6. 2001
  8. ncbi Recent advances in the relationship between obesity, inflammation, and insulin resistance
    Jean Philippe Bastard
    INSERM U680, Faculte de Medecine Pierre et Marie Curie, site Saint Antoine, Universite Pierre et Marie Curie, Paris 6 et Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, 75970 Paris Cedex 20, France
    Eur Cytokine Netw 17:4-12. 2006
  9. ncbi Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
  10. ncbi Adipose tissue, adipokines, and inflammation
    Giamila Fantuzzi
    Department of Human Nutrition, University of Illinois at Chicago, USA
    J Allergy Clin Immunol 115:911-9; quiz 920. 2005

Detail Information

Publications293 found, 100 shown here

  1. ncbi Effects of the obese gene product on body weight regulation in ob/ob mice
    M A Pelleymounter
    Department of Neurobiology, Amgen, Inc, Thousand Oaks, CA 91320, USA
    Science 269:540-3. 1995
    ..These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite...
  2. ncbi Weight-reducing effects of the plasma protein encoded by the obese gene
    J L Halaas
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
    Science 269:543-6. 1995
    ..2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores...
  3. ncbi Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
    L A Campfield
    Department of Metabolic Diseases, Hoffmann La Roche Incorporated, Nutley, NJ 07110, USA
    Science 269:546-9. 1995
    ..The behavioral effects after brain administration suggest that OB protein can act directly on neuronal networks that control feeding and energy balance...
  4. ncbi Identification and expression cloning of a leptin receptor, OB-R
    L A Tartaglia
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 83:1263-71. 1995
    The ob gene product, leptin, is an important circulating signal for the regulation of body weight...
  5. ncbi Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    H Chen
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 84:491-5. 1996
    OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an alternatively spliced transcript that encodes a form of mouse OB-R with a long intracellular domain...
  6. ncbi Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
    ..A complex physiological system has evolved to regulate fuel stores and energy balance at an optimum level. Leptin, a hormone secreted by adipose tissue, and its receptor are integral components of this system...
  7. ncbi The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 7:941-6. 2001
    ..in lipoatrophic mice was completely reversed by the combination of physiological doses of adiponectin and leptin, but only partially by either adiponectin or leptin alone...
  8. ncbi Recent advances in the relationship between obesity, inflammation, and insulin resistance
    Jean Philippe Bastard
    INSERM U680, Faculte de Medecine Pierre et Marie Curie, site Saint Antoine, Universite Pierre et Marie Curie, Paris 6 et Service de Biochimie et Hormonologie, Hopital Tenon, AP HP, 75970 Paris Cedex 20, France
    Eur Cytokine Netw 17:4-12. 2006
    ..Most of them are overproduced during obesity, including leptin, TNF-alpha, IL-6 and resistin...
  9. ncbi Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
    ..4 microg/mL, P<0.001 in men; 6.3+/-0.8 versus 7.6+/-0. 7 microg/mL in women). In contrast, plasma levels of leptin did not differ between diabetic patients with and without CAD...
  10. ncbi Adipose tissue, adipokines, and inflammation
    Giamila Fantuzzi
    Department of Human Nutrition, University of Illinois at Chicago, USA
    J Allergy Clin Immunol 115:911-9; quiz 920. 2005
    ..tissue produces and releases a variety of proinflammatory and anti-inflammatory factors, including the adipokines leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines, such as TNF-alpha, IL-6, monocyte ..
  11. ncbi Adipocytokines: mediators linking adipose tissue, inflammation and immunity
    Herbert Tilg
    Christian Doppler Research Laboratory for Gut Inflammation and Department of Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Nat Rev Immunol 6:772-83. 2006
    ..The adipocytokines adiponectin and leptin have emerged as the most abundant adipocyte products, thereby redefining adipose tissue as a key component not ..
  12. ncbi Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite
    Karine Spiegel
    University of Chicago, Chicago, Illinois, USA
    Ann Intern Med 141:846-50. 2004
    ..Total sleep deprivation in rodents and in humans has been associated with hyperphagia. Over the past 40 years, self-reported sleep duration in the United States has decreased by almost 2 hours...
  13. ncbi A role for ghrelin in the central regulation of feeding
    M Nakazato
    Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
    Nature 409:194-8. 2001
    ..Ghrelin augmented NPY gene expression and blocked leptin-induced feeding reduction, implying that there is a competitive interaction between ghrelin and leptin in feeding ..
  14. ncbi AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    Yasuhiko Minokoshi
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 428:569-74. 2004
    ..that AMPK activity is inhibited in arcuate and paraventricular hypothalamus (PVH) by the anorexigenic hormone leptin, and in multiple hypothalamic regions by insulin, high glucose and refeeding...
  15. ncbi Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    G M Lord
    Imperial College School of Medicine, Department of Immunology, The Hammersmith Hospital, London, UK
    Nature 394:897-901. 1998
    ..The cloning of the obese gene and identification of its protein product leptin has provided fundamental insight into the hypothalamic regulation of body weight...
  16. ncbi Abnormal splicing of the leptin receptor in diabetic mice
    G H Lee
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 379:632-5. 1996
    ..Previous data suggest that the db gene encodes the receptor for the obese (ob) gene product, leptin. A leptin receptor was recently cloned from choroid plexus and shown to map to the same 6-cM interval on mouse ..
  17. pmc Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells
    Vishwa Deep Dixit
    Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
    J Clin Invest 114:57-66. 2004
    ..Ghrelin led to a dose-dependent inhibition of leptin-induced cytokine expression, while leptin upregulated GHS-R expression on human T lymphocytes...
  18. ncbi Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men
    M A Banerji
    Department of Medicine, State University of New York Health Science Center, Brooklyn 11203, USA
    J Clin Endocrinol Metab 84:137-44. 1999
    ..test whether insulin action was related to total or regional adiposity and to explore the potential role of plasma leptin and lipids, we measured insulin-mediated glucose disposal by the euglycemic insulin clamp, adipose distribution ..
  19. pmc Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index
    Shahrad Taheri
    Howard Hughes Medical Institute, Stanford University, Palo Alto, California, USA
    PLoS Med 1:e62. 2004
    ..An association between short habitual sleep time and increased body mass index (BMI) has been reported in large population samples. The potential role of metabolic hormones in this association is unknown...
  20. ncbi Leptin as an immunomodulator
    Claudio Procaccini
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli, Federico II, Via Pansini 5, 80131 Napoli, Italy
    Mol Aspects Med 33:35-45. 2012
    b>Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions...
  21. ncbi Adipokines: the missing link between insulin resistance and obesity
    B Antuna-Puente
    INSERM U680, Faculte de Medecine Saint Antoine, Universite Pierre et Marie Curie Paris 6, 75012 Paris, France
    Diabetes Metab 34:2-11. 2008
    ..Adipose tissue is known to express and secrete a variety of products known as 'adipokines', including leptin, adiponectin, resistin and visfatin, as well as cytokines and chemokines such as tumor necrosis factor-alpha, ..
  22. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
    ..The hormone leptin increases hypothalamic mTOR activity, and the inhibition of mTOR signaling blunts leptin's anorectic effect...
  23. ncbi Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    Yasuhiko Minokoshi
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 415:339-43. 2002
    b>Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and neuroendocrine function...
  24. ncbi Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling
    Kento Imajo
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, 3 9 Fuku ura, Yokohama, Japan
    Cell Metab 16:44-54. 2012
    ..Here, we demonstrate that upregulation of CD14 by leptin-mediated signaling is critical to hyperreactivity against endotoxin during NASH progression...
  25. ncbi Role of brain insulin receptor in control of body weight and reproduction
    J C Bruning
    Klinik II und Poliklinik für Innere Medizin and Center of Molecular Medicine ZMMK der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Science 289:2122-5. 2000
    ..food intake, and both male and female mice developed diet-sensitive obesity with increases in body fat and plasma leptin levels, mild insulin resistance, elevated plasma insulin levels, and hypertriglyceridemia...
  26. ncbi Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    M A Cowley
    The Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA
    Nature 411:480-4. 2001
    The administration of leptin to leptin-deficient humans, and the analogous Lepob/Lepob mice, effectively reduces hyperphagia and obesity...
  27. ncbi Congenital leptin deficiency is associated with severe early-onset obesity in humans
    C T Montague
    University of Cambridge, Department of Medicine, UK
    Nature 387:903-8. 1997
    The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific secreted protein which has profound effects on appetite and energy expenditure...
  28. ncbi Trophic action of leptin on hypothalamic neurons that regulate feeding
    Sebastien G Bouret
    Division of Neuroscience, Oregon National Primate Research Center and Oregon Health and Science University, Beaverton, OR 97006, USA
    Science 304:108-10. 2004
    In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of neurons in the arcuate nucleus of the hypothalamus (ARH)...
  29. pmc A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure
    Vijay K Yadav
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Cell 138:976-89. 2009
    b>Leptin inhibition of bone mass accrual requires the integrity of specific hypothalamic neurons but not expression of its receptor on these neurons. The same is true for its regulation of appetite and energy expenditure...
  30. ncbi Neonatal leptin treatment reverses developmental programming
    M H Vickers
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland 1020, New Zealand
    Endocrinology 146:4211-6. 2005
    ..Using this model of maternal undernutrition, we investigated the effects of neonatal leptin treatment on the metabolic phenotype of adult female offspring. Leptin treatment (rec-rat leptin, 2.5 microg/g...
  31. ncbi Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    M Maffei
    Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021, USA
    Nat Med 1:1155-61. 1995
    b>Leptin, the gene product of the obese gene, may play an important role in regulating body weight by signalling the size of the adipose tissue mass...
  32. pmc Diet-induced obese mice develop peripheral, but not central, resistance to leptin
    M van Heek
    Department of CNS and Cardiovascular Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Clin Invest 99:385-90. 1997
    b>Leptin administration reduces obesity in leptin-deficient ob/ob mice; its effects in obese humans, who have high circulating leptin levels, remain to be determined...
  33. ncbi Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
    Gideon R Hajer
    Department of Vascular Medicine, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Eur Heart J 29:2959-71. 2008
    ..g. tumour necrosis factor-alpha, interleukin-6, adiponectin, leptin, and plasminogen activator inhibitor-1...
  34. ncbi Endoplasmic reticulum stress plays a central role in development of leptin resistance
    Lale Ozcan
    Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 9:35-51. 2009
    b>Leptin has not evolved as a therapeutic modality for the treatment of obesity due to the prevalence of leptin resistance in a majority of the obese population...
  35. ncbi Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade
    Amaia Rodríguez
    Metabolic Research Laboratory, University of Navarra, 31080 Pamplona, Spain
    J Clin Endocrinol Metab 96:E586-97. 2011
    ..The impact of obesity and obesity-associated type 2 diabetes as well as the potential regulatory role of insulin and leptin on aquaglyceroporins (AQP) 3, 7, and 9 were analyzed.
  36. ncbi Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN, Boston, MA 02215, USA
    Neuron 42:983-91. 2004
    ..and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of leptin signaling in these neurons has not yet been directly tested...
  37. ncbi Obesity wars: molecular progress confronts an expanding epidemic
    Jeffrey S Flier
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cell 116:337-50. 2004
    ....
  38. pmc Leptin and the central nervous system control of glucose metabolism
    Gregory J Morton
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Physiol Rev 91:389-411. 2011
    ..This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes...
  39. pmc Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin
    Guey Ying Liao
    Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, USA
    Nat Med 18:564-71. 2012
    ..Here we show the relationship between Bdnf mRNA with a long 3' UTR (long 3' UTR Bdnf mRNA), leptin, neuronal activation and body weight...
  40. pmc Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis
    Alison S Reed
    Diabetes Center and the Department of Pediatrics, University of California San Francisco, San Francisco, California, USA
    Diabetes 59:894-906. 2010
    Hypothalamic leptin resistance is found in most common forms of obesity, such as diet-induced obesity, and is associated with increased expression of suppressor of cytokine signaling 3 (Socs3) in the hypothalamus of diet-induced obese ..
  41. pmc Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Eur J Pharmacol 660:2-12. 2011
    ..This review attempts to highlight contributions to our current understanding of how numerous neuromodulators (leptin, insulin, and serotonin) integrate with the central melanocortin system to coordinate alterations in energy and ..
  42. pmc Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
    Linh Vong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, EC CLS717, Boston, MA 02215, USA
    Neuron 71:142-54. 2011
    b>Leptin acts in the brain to prevent obesity. The underlying neurocircuitry responsible for this is poorly understood, in part because of incomplete knowledge regarding first-order, leptin-responsive neurons...
  43. ncbi Central insulin and leptin-mediated autonomic control of glucose homeostasis
    Joseph S Marino
    Center for Diabetes and Endocrine Research, College of Medicine, The University of Toledo, Toledo, OH 43614, USA
    Trends Endocrinol Metab 22:275-85. 2011
    ..indicates that the brain is the master regulator of glucose homeostasis, and that hypothalamic insulin and leptin signaling in particular play a crucial role in the development of insulin resistance...
  44. ncbi Neurogenesis in the hypothalamus of adult mice: potential role in energy balance
    Maia V Kokoeva
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Science 310:679-83. 2005
    ..neuronal markers and show functional phenotypes relevant for energy-balance control, including a capacity for leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3)...
  45. pmc Sixteen years and counting: an update on leptin in energy balance
    Laurent Gautron
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 121:2087-93. 2011
    Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and secreted by white adipose tissue...
  46. ncbi Adiponectin and metabolic syndrome
    Yuji Matsuzawa
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School, Sumitomo Hospital, Osaka, Japan
    Arterioscler Thromb Vasc Biol 24:29-33. 2004
    ..Adiponectin plasma levels decrease with the accumulation of visceral adipose tissue. In this review, we discuss the link of adiponectin to visceral adiposity, insulin resistance, and vascular diseases...
  47. pmc Adipokines and insulin resistance
    Katja Rabe
    Department of Internal Medicine II, University of Munich, Munich, Germany
    Mol Med 14:741-51. 2008
    ..review, we summarize current data on the effect of the adipose tissue-derived hormones adiponectin, chemerin, leptin, omentin, resistin, retinol binding protein 4, tumor necrosis factor-alpha and interleukin-6, vaspin, and visfatin ..
  48. ncbi Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action
    R C Frederich
    Division of Endocrinology, Beth Israel Hospital Research North, Boston, Massachusetts 02215, USA
    Nat Med 1:1311-4. 1995
    ..The ob gene protein product, leptin, is an adipocyte-derived circulating protein...
  49. pmc MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    Andre Kleinridders
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD and Center of Molecular Medicine Cologne CMMC, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 10:249-59. 2009
    ..Here, we demonstrate that palmitate acting in the central nervous system (CNS) inhibits leptin-induced anorexia and Stat3 activation...
  50. ncbi Adipose tissue as an endocrine organ
    Rexford S Ahima
    University of Pennsylvania School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA 19104, USA
    Obesity (Silver Spring) 14:242S-249S. 2006
    ..A rise in leptin signals satiety to the brain through receptors in hypothalamic and brainstem neurons...
  51. ncbi Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    Heike Munzberg
    Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 145:4880-9. 2004
    b>Leptin resistance in diet-induced obese (DIO) mice is characterized by elevated serum leptin and a decreased response to exogenous leptin and is caused by unknown defects in the central nervous system...
  52. ncbi Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial
    S B Heymsfield
    Weight Control Unit, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    JAMA 282:1568-75. 1999
    The protein hormone leptin is important to the homeostatic regulation of body weight. Treatment with exogenous leptin may affect weight loss.
  53. pmc Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice
    Amandine Everard
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 60:2775-86. 2011
    ..To investigate deep and comprehensive analysis of gut microbial communities and biological parameters after prebiotic administration in obese and diabetic mice...
  54. ncbi Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela, S Francisco s n, 15782 Santiago de Compostela A Coruña, Spain
    Cell Metab 7:389-99. 2008
    ..Overall, our results indicate that modulation of hypothalamic fatty acid metabolism specifically in the VMH in response to ghrelin is a physiological mechanism that controls feeding...
  55. ncbi Leptin and the regulation of endothelial function in physiological and pathological conditions
    Jerzy Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    Clin Exp Pharmacol Physiol 39:168-78. 2012
    ..This detrimental effect of obesity is mediated, in part, by excessive production of the adipose tissue hormone leptin. Under physiological conditions leptin induces endothelium-dependent vasorelaxation by stimulating nitric oxide (..
  56. ncbi Leptin regulation of bone resorption by the sympathetic nervous system and CART
    Florent Elefteriou
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 434:514-20. 2005
    ..signalling via beta2-adrenergic receptors (Adrb2) present on osteoblasts controls bone formation downstream of leptin. Here we show, by analysing Adrb2-deficient mice, that the sympathetic nervous system favours bone resorption by ..
  57. pmc Leptin revisited: its mechanism of action and potential for treating diabetes
    Roberto Coppari
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Rev Drug Discov 11:692-708. 2012
    Since the discovery of leptin in 1994, we now have a better understanding of the cellular and molecular mechanisms underlying its biological effects...
  58. pmc Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice
    Jialin Xu
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island, USA
    Diabetes 61:3208-18. 2012
    ..Constitutive Nrf2 activation inhibited lipid accumulation in white adipose tissue, suppressed adipogenesis, induced insulin resistance and glucose intolerance, and increased hepatic steatosis in Lep(ob/ob) mice...
  59. ncbi Immunological functions of leptin and adiponectin
    Fortunata Carbone
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Napoli 80131, Italy c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli 80131, Italy
    Biochimie 94:2082-8. 2012
    ..In this context, leptin and adiponectin, the two most abundant adipocyte products, represent one of the best example of adipocytokines ..
  60. ncbi Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
    Karen L Teff
    Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
    J Clin Endocrinol Metab 89:2963-72. 2004
    Previous studies indicate that leptin secretion is regulated by insulin-mediated glucose metabolism...
  61. ncbi Leptin in depressed women: cross-sectional and longitudinal data from an epidemiologic study
    Julie A Pasco
    Department of Clinical and Biomedical Sciences Barwon Health, The University of Melbourne, Geelong 3220, Australia
    J Affect Disord 107:221-5. 2008
    There is conflicting evidence regarding levels of leptin in depression...
  62. pmc Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance
    Marc Schneeberger
    Diabetes and Obesity Research Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, 08036 Barcelona, Spain Department of Endocrinology and Nutrition, Hospital Clínic School of Medicine, University of Barcelona, 08036 Barcelona, Spain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, 08036 Barcelona, Spain
    Cell 155:172-87. 2013
    ..Hypothalamic ER stress has emerged as a causative factor for the development of leptin resistance, but the underlying mechanisms are largely unknown...
  63. ncbi Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob mice
    Shoshana M Bartell
    Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA
    J Bone Miner Res 26:1710-20. 2011
    Both central and peripheral leptin administrations reduce body weight, food intake, and adiposity in ob/ob mice...
  64. ncbi Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    S C Chua
    Laboratory of Human Behavior and Metabolism, Rockefeller University, New York 10021, USA
    Science 271:994-6. 1996
    ..The cloning of ob, and the demonstration that it encodes a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects of this hypothesis...
  65. pmc Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation
    Satya P Kalra
    Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, PO Box 100244, Gainesville, FL 32610 0244, United States
    Peptides 30:1957-63. 2009
    ..its role in energy homeostasis is firmly established, the evidence accumulated over a decade linking the adipocyte leptin-hypothalamus axis in the pathogenesis of diabetes mellitus has received little attention in the contemporary ..
  66. pmc Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
    Jose Donato
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Clin Invest 121:355-68. 2011
    ..The adipocyte-derived hormone leptin is a key metabolic signal to the neuroendocrine reproductive axis...
  67. pmc Leptin in human physiology and therapeutics
    Tina A Dardeno
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States
    Front Neuroendocrinol 31:377-93. 2010
    b>Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions...
  68. ncbi Rapid rewiring of arcuate nucleus feeding circuits by leptin
    Shirly Pinto
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 304:110-5. 2004
    The fat-derived hormone leptin regulates energy balance in part by modulating the activity of neuropeptide Y and proopiomelanocortin neurons in the hypothalamic arcuate nucleus...
  69. ncbi Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
    Sara Aleffi
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 42:1339-48. 2005
    b>Leptin upregulates collagen expression in hepatic stellate cells (HSCs), but the possible modulation of other actions has not been elucidated...
  70. ncbi Leptin and cancer
    Cecilia Garofalo
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende, Cosenza, Italy
    J Cell Physiol 207:12-22. 2006
    ..This review will focus on the link between leptin, a cytokine that is elevated in obese individuals, and cancer development...
  71. ncbi Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women
    Miyao Matsubara
    Division of Endocrinology and Metabolism, Otaru City General Hospital, Otaru, Japan
    Eur J Endocrinol 147:173-80. 2002
    ..Adiponectin, a novel adipocyte-derived collagen-like protein, is the gene product of the adipose most-abundant gene transcript 1 (apM1), which has been considered to have anti-inflammatory and anti-atherogenic effects...
  72. ncbi Adipocytokines: leptin--the classical, resistin--the controversical, adiponectin--the promising, and more to come
    Antje Koerner
    University Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21 25, Germany
    Best Pract Res Clin Endocrinol Metab 19:525-46. 2005
    ..This report aims to review some of the recent topics of adipocytokine research that may be of particular importance...
  73. ncbi Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
    Ling Fu
    Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Endocrinology 145:2594-603. 2004
    ..the diabetes that develops in mice made obese by genetic ablation of brown adipose tissue or genetic absence of leptin. To explore the mechanisms underlying the FGF19-mediated increase in metabolic rate, we profiled the FGF19-induced ..
  74. pmc Leptin targets in the mouse brain
    Michael M Scott
    Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Comp Neurol 514:518-32. 2009
    The central actions of leptin are essential for homeostatic control of adipose tissue mass, glucose metabolism, and many autonomic and neuroendocrine systems...
  75. ncbi Adipokines in liver diseases
    Fabio Marra
    Department of Internal Medicine, University of Florence, Florence, Italy
    Hepatology 50:957-69. 2009
    ..As a result, adipose tissue inflammation is associated with a modification in the pattern of adipokine secretion. Leptin, adiponectin, and resistin are the best-studied molecules in this class, but cytokines such as tumor necrosis ..
  76. ncbi Leptin in the regulation of immunity, inflammation, and hematopoiesis
    G Fantuzzi
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    J Leukoc Biol 68:437-46. 2000
    b>Leptin, the product of the ob gene, is a pleiotropic molecule that regulates food intake as well as metabolic and endocrine functions. Leptin also plays a regulatory role in immunity, inflammation, and hematopoiesis...
  77. pmc Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up
    Joshua P Thaler
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington 98109, USA
    Endocrinology 151:4109-15. 2010
    ..suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling...
  78. pmc Leptin in human physiology and pathophysiology
    Christos S Mantzoros
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Am J Physiol Endocrinol Metab 301:E567-84. 2011
    b>Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted hormone with pleiotropic effects in the physiology and pathophysiology of energy homeostasis, endocrinology, and metabolism...
  79. ncbi Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
    ..Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway...
  80. ncbi Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids
    Mohamed S Zaibi
    Clore Laboratory, University of Buckingham, Buckingham, UK
    FEBS Lett 584:2381-6. 2010
    GPR41 is reportedly expressed in murine adipose tissue and mediates short chain fatty acid (SCFA)-stimulated leptin secretion by activating Galpha(i)...
  81. pmc Recent advances in understanding leptin signaling and leptin resistance
    David L Morris
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Mchigan 48109 0622, USA
    Am J Physiol Endocrinol Metab 297:E1247-59. 2009
    The brain controls energy homeostasis and body weight by integrating various metabolic signals. Leptin, an adipose-derived hormone, conveys critical information about peripheral energy storage and availability to the brain...
  82. ncbi Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    David E Cummings
    Department of Medicine, University of Washington the Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    N Engl J Med 346:1623-30. 2002
    ..Because ghrelin is produced primarily by the stomach, weight loss after gastric bypass surgery may be accompanied by impaired ghrelin secretion...
  83. ncbi Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    D Huszar
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Cell 88:131-41. 1997
    ..Our data identify a novel signaling pathway in the mouse for body weight regulation and support a model in which the primary mechanism by which agouti induces obesity is chronic antagonism of the MC4-R...
  84. pmc Maternal obesity induced by diet in rats permanently influences central processes regulating food intake in offspring
    Shona L Kirk
    Division of Reproduction and Endocrinology, King s College London, London, UK
    PLoS ONE 4:e5870. 2009
    ..We now report that offspring of obese (OffOb) rats display an amplified and prolonged neonatal leptin surge, which is accompanied by elevated leptin mRNA expression in their abdominal white adipose tissue...
  85. ncbi Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    Harveen Dhillon
    Department of Medicine, Division of Endocrinology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Neuron 49:191-203. 2006
    b>Leptin, an adipocyte-derived hormone, acts directly on the brain to control food intake and energy expenditure. An important question is the identity of first-order neurons initiating leptin's anti-obesity effects...
  86. ncbi Leptin: a review of its peripheral actions and interactions
    S Margetic
    Central Queensland University, School of Chemical and Biomedical Sciences, Queensland, Australia
    Int J Obes Relat Metab Disord 26:1407-33. 2002
    Following the discovery of leptin in 1994, the scientific and clinical communities have held great hope that manipulation of the leptin axis may lead to the successful treatment of obesity...
  87. pmc Obesity and asthma
    David A Beuther
    National Jewish Medical and Research Center, 1400 Jackson Street, J220, Denver, CO 80206, USA
    Am J Respir Crit Care Med 174:112-9. 2006
    ..Animal experiments have evaluated the effects of leptin and obesity on airway inflammation in response to both allergic and nonallergic exposures and suggest that airway ..
  88. ncbi PTP1B regulates leptin signal transduction in vivo
    Janice M Zabolotny
    Division of Endocrinology and Metabolism, Division of Hematology and Oncology, Department of Medicine, Boston, MA, USA
    Dev Cell 2:489-95. 2002
    ..However, the molecular basis for resistance to obesity has been unclear. Here we show that PTP1B regulates leptin signaling. In transfection studies, PTP1B dephosphorylates the leptin receptor-associated kinase, Jak2...
  89. pmc Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
    Janice M Zabolotny
    Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 283:14230-41. 2008
    Protein-tyrosine phosphatase 1B (PTP1B) is a major negative regulator of insulin and leptin sensitivity. PTP1B overexpression in adipose tissue and skeletal muscle of humans and rodents may contribute to insulin resistance and obesity...
  90. ncbi Recombinant human leptin in women with hypothalamic amenorrhea
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    N Engl J Med 351:987-97. 2004
    ..and other endocrine axes due to energy deficits are associated with low levels of the adipocyte-secreted hormone leptin and may result in hypothalamic amenorrhea...
  91. pmc Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
    Neeraj K Saxena
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 67:2497-507. 2007
    Various epidemiologic studies have shown that obesity is associated with hepatocellular carcinoma. Leptin, the key player in the regulation of energy balance and body weight control, also acts as a growth factor on certain organs in both ..
  92. ncbi STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    Sarah H Bates
    Research Division, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
    Nature 421:856-9. 2003
    Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb)...
  93. pmc Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
    Jennifer W Hill
    Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, College of Medicine, The University of Toledo, Toledo, OH 43614, USA
    Cell Metab 11:286-97. 2010
    Circulating leptin and insulin convey information regarding energy stores to the central nervous system, particularly the hypothalamus...
  94. ncbi A key role of leptin in the control of regulatory T cell proliferation
    Veronica De Rosa
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, 80131 Napoli, Italy
    Immunity 26:241-55. 2007
    We report here that leptin can act as a negative signal for the proliferation of human naturally occurring Foxp3(+)CD4(+)CD25(+) regulatory T (T(reg)) cells...
  95. pmc Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    I Sadaf Farooqi
    University Department of Medicine, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Invest 110:1093-103. 2002
    The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in ..
  96. pmc Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice
    Jiejie Li
    Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA
    Pharmacol Biochem Behav 101:564-74. 2012
    ..Activation of JNK may contribute to the increased phospho-tau in the db/db mice. Metformin attenuates AD-like biochemical changes in the brain of these mice...
  97. ncbi A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor
    David A Bechtold
    University of Manchester, Manchester M13 9PT, UK
    Curr Biol 22:70-7. 2012
    ..Hypothalamic responses to energy signals, such as leptin, influence the expression of torpor [4-7]...
  98. ncbi The clock gene Rev-erbα regulates pancreatic β-cell function: modulation by leptin and high-fat diet
    Elaine Vieira
    Instituto de Bioingenieria, Universidad Miguel Hernandez, Avenida de la Universidad s n, 03202 Elche, Spain
    Endocrinology 153:592-601. 2012
    ..role of this clock gene in the pancreatic β-cell function and to analyze whether its expression is modulated by leptin and diet-induced obesity...
  99. ncbi A leptin missense mutation associated with hypogonadism and morbid obesity
    A Strobel
    Nat Genet 18:213-5. 1998
  100. pmc Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis
    M Otero
    NEIRID NeuroEndocrine Interactions in Rheumatology and Inflammatory Diseases Laboratory, Santiago University Clinical Hospital, Spain
    Ann Rheum Dis 65:1198-201. 2006
    ..Rheumatoid arthritis is a chronic autoimmune inflammatory condition characterised by polyarthritis and severe change in body mass and neuroendocrine environment...
  101. ncbi Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa
    C Ruth González
    Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain Ciber Fisiopatología de la Obesidad y Nutrición CIBERobn, Spain
    J Mol Endocrinol 41:415-21. 2008
    ..with high-circulating ghrelin levels, we found similar mRNA expression of GOAT in fed and fasted rats; exogenous leptin administration markedly increase GOAT mRNA levels in the stomach mucosa of fasted rats...

Research Grants78

  1. Leptin modulation of insulin action in the islet b-cell
    Rohit Kulkarni; Fiscal Year: 2005
    ..Receptors for insulin and IGF-I and for leptin are expressed in the pancreatic islets, and recent reports have suggested that leptin can act through some ..
  2. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..function (von Willebrand factor and E-selectin) and adipocytokines that represent insulin resistance (adiponectin, leptin, resistin, tumor necrosis factor-1, plasminogen activator inhibitor-1) and inflammation (C-reactive protein) ..
  3. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..to oxLDL, LpPLA2, sPLA2, myeloperoxidase);(2) insulin resistance and adiposity (insulin, C-peptide, adiponectin, leptin, resistin, liver function enzymes);(3) renal function (creatinine, cystatin C, ADMA, uric acid, 25(OH)vitamin D, ..
  4. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..Secondary outcomes will be plasma levels of catecholamines, free fatty acids, leptin and CRP. We will also collect daily data on weight, caloric intake, and energy expenditure...
  5. Central Action of Brain-Derived Neurotrophic Factor in Male and Female Rats
    Haifei Shi; Fiscal Year: 2010
    ..they directly receive input from the proopiomelanocortin (POMC) neurons that are activated by an adiposity signal leptin. Females have greater sensitivity to central leptin than males, suggested by a greater anorexic effect of central ..
  6. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..b-cell proliferation, insulin production, insulin sensitivity and adiponectin expression as a feedback loop of Leptin's regulation of osteoblasts...
  7. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..arcuate glutamate neurons respond to long distance cues relating to energy homeostasis, particularly glucose and leptin. Together, these experiments will reveal the organization and cellular actions and responses of a unique and ..
  8. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..serum amyloid A, interleukin-6), insulin like growth factor 1 and binding protein 3, and adipokines (adiponectin, leptin)...
  9. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..it appears that T1AM is an endogenous anorectic agent, with a biological activity on feeding behavior similar to leptin and melanocortins, which are endogenous signaling molecules that act via central pathways in the actuate nucleus ..
  10. Neural Functioning of Feeding Centers in Obese Youth
    ROBERT STANLEY SHERWIN; Fiscal Year: 2013
    ..prediabetes/T2DM present with severe peripheral insulin resistance, marked hyperinsulinemia and relatively low leptin levels...
  11. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    b>Leptin action on reproductive functions is well established. Mice deficient (ob/ob) or resistant (db/db) to leptin are infertile, and leptin administration to ob/ob mice, but not weight loss alone, restores their fertility...
  12. Obesity: neural control of body weight and metabolism
    Barry E Levin; Fiscal Year: 2013
    ..b>Leptin is the most important of these hormonal signals...
  13. Growth Hormone Regulation of SH2B1
    Christin Carter-Su; Fiscal Year: 2013
    ..mice) is consistent with SH2B1 being a signaling molecule for multiple ligands, including growth hormone (GH), leptin, and insulin...
  14. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..Adiponection and leptin will be assessed as potential intermediaries in any associations between ucOC and these outcomes...
  15. ROLE OF FORKHEAD PROTEINS IN INSULIN ACTION
    Domenico Accili; Fiscal Year: 2013
    ..synthesis;ii, identification of novel roles of Foxo1 in the hypothalamic arcuate nucleus, linking insulin and leptin signaling with neuropeptide synthesis and action;iii, identification of the obesity susceptibility gene ..
  16. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..e. like leptin, T1AM appears to act as an endogenous anorectic agent...
  17. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..including adrenal and gonadal steroids, insulin-like growth factors, growth hormone, and ghrelin, adiponectin, and leptin. The proposed project will test hypotheses raised by the pilot imaging data, in particular whether hormonal ..
  18. Mechanisms of Diabetic Hyperphagia and Insulin Resistance
    Michael W Schwartz; Fiscal Year: 2012
    ..VMN) to changes in the humoral milieu, including marked decreases in the circulating levels of both insulin and leptin, and elevated levels of ghrelin...
  19. Comparative Effectiveness of Medical Therapy vs. Bariatric Surgery for Obese T2DM
    DAVID BRADLEY contact LAUTZ; Fiscal Year: 2010
    ..Gastrointestinal hormones including incretins (GLP-1, GIP) and appetite regulating peptides (ghrelin, PYY, leptin) will be compared...
  20. Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2
    David E Cohen; Fiscal Year: 2013
    ..Aim 2 will utilize high fat fed Pct-/- and Them2-/- mice, as well as leptin-deficient ob/ob mice to establish the pathogenic roles of PC-TP and Them2 in ER stress...
  21. Leptin as a Regulator of T Cell Metabolism and Function
    NANCIE MACIVER; Fiscal Year: 2013
    ..Deficits in adipose tissue, as seen in malnutrition, lead to a deficiency of the adipose hormone leptin, which plays a critical role in metabolic regulation as well as the development of immune function...
  22. Simultaneous Insulin and Leptin Signaling in POMC Neurons Promotes Fertility and
    LATRICE DOREEN FAULKNER; Fiscal Year: 2013
    ..By simultaneously deleting the Pro-opiomelanocortin (POMC) neuron leptin and insulin receptors in a murine model (IR/LepRPOMC), we created female mice that develop metabolic and ..
  23. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
    ..between these measures and four inflammatory adipocytokines (interleukin-6, tumor necrosis factor - 1, leptin, adiponectin), CVD risk factors, and CAC...
  24. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..risk factors (Specific Aim #2: blood pressure, blood glucose, insulin, lipids, C-reactive protein, adiponectin, leptin, tumor necrosis factor-1, interleukin-6), functional status, and quality of life (Specific Aim #3: life space ..
  25. Mechanisms of diet-induced leptin resistance in ARC and VTA
    Philip J Scarpace; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): One potential causative factor of diet-induced obesity (DIO) is leptin resistance. Leptin is a potent anorexic hormone in most lean animals...
  26. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    ..on the hormones most different between the sexes in adults and late adolescents: androgenic steroids and estrogen, leptin and prolactin...
  27. Leptin function &resistance in midbrain VTA &SN in reward eating &obesity
    YI NONE ZHANG; Fiscal Year: 2013
    ..Recent data underpin a direct leptin function in the ventral tegmental area (VTA) of the midbrain reward circuitry to temper high-fat (HF) feeding...
  28. PERIPHERAL AND CENTRAL INTERACTIONS IN ENERGY BALANCE
    Barbara B Kahn; Fiscal Year: 2010
    ..In the past grant period the projects in this orogram investigated the central and peripheral actions of leptin. This included the neural pathways activated by leptin and the cellular pathways engaged by leptin in the CMS and ..
  29. Effect of exposure to organochlorine compounds on the development of obesity and
    GEORGE E HOWELL; Fiscal Year: 2011
    ..The current preliminary data indicate that exposure to DDE decreases adipogenesis while increasing the release of leptin and interleukin-6 from adipocytes...
  30. RYGB Improves Metabolism by Interrupting the Gastric Adipose Tissue Axis
    Naji N Abumrad; Fiscal Year: 2013
    ..These improvements are preceded by significant reductions in the circulating levels of gastric-derived ghrelin and leptin, occurring as early as 15 minutes after the surgical interruption of stomach during the RYGB procedure...
  31. Effect of Perinatal Diet on Developmental Programming of the Skeleton
    Mary L Bouxsein; Fiscal Year: 2010
    ..diet on skeletal acquisition, but most compelling is the observation that prenatal diet alters the perinatal leptin surge, which establishes the sensitivity of hypothalamic neurons to postnatal leptin...
  32. The Impact of Heat Shock Protein Expression on Inflammation and Insulin Action
    Andrea L Hevener; Fiscal Year: 2013
    ..of HSP72 will protect against inflammation, insulin resistance, and obesity induced by high fat diet (HFD) or leptin deficiency...
  33. Depression, Adipocytokines and Metabolic Dysregulation in Black and White Women
    Susan A Everson Rose; Fiscal Year: 2010
    ..an anti-inflammatory adipocytokine with insulin-sensitizing, anti-thrombotic and anti-atherogenic effects, and leptin, a pro-inflammatory adipocytokine intimately involved in regulation of metabolism, energy balance, and autonomic ..
  34. Brain interleukin-18 control of food intake and energy expenditure
    Eric P Zorrilla; Fiscal Year: 2013
    ..of IL- 18 suppresses food intake and weight regain in hungry mice as potently as does the adipocyte hormone leptin and does so without producing the adverse malaise, fever or HPA-axis activation classically associated with ..
  35. Mechanisms for the Effects of Hypothalamic PTP1B on Energy Balance
    KARYN JOANNE CATALANO; Fiscal Year: 2010
    ..g. exercise), and one key regulator of energy balance is the fat-derived hormone leptin, which acts primarily in the brain...
  36. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2009
    ..The anorexigenic peptide leptin is released into the blood in proportion to the amount of body fat and plays a central role in activating the ..
  37. Humoral factors in gender differences in blood pressure control
    Jane F Reckelhoff; Fiscal Year: 2013
    ..in women: elevated BP, ovarian dysfunction, increases in body weight and visceral adiposity, increased plasma leptin and TNF-[unreadable]...
  38. Lipocalin 2 in Inflammation and Metabolic Control
    Xiaoli Chen; Fiscal Year: 2012
    ..Most strikingly, LCN2 regulates the adipocyte production of leptin and adiponectin...
  39. Maternal Hyperinsulinemia and Fetal Programming
    Mulchand S Patel; Fiscal Year: 2011
    ..genes, (ii) the development of arcuate nucleus projections and (iii) the functional responses to exogenous leptin will be determined in 1-HC and 2-HC rats...
  40. Functional significance of Siglec-6, a novel leptin receptor, in human placental
    Virginia Winn; Fiscal Year: 2013
    ..For this proposal, we focus the roles of on two of the differentially expressed genes- leptin and Siglec-6 (sialic acid binding Ig like lectin 6) - in trophoblast invasion...
  41. Mechanisms of Coronary Arteriolar Dysfunction in Type 2 Diabetes
    Khalid Matrougui; Fiscal Year: 2013
    ..of EGFR tyrosine kinase phosphorylation in coronary arteriolar from type 2 diabetic mice (db-/db- mice lacking leptin receptor gene) associated with coronary arteriolar dysfunction characterized by a reduced endothelial-dependent ..
  42. Mechanical and Osmotic Signaling in Chondrocytes
    Farshid Guilak; Fiscal Year: 2013
    ..of the modulation of TRPV4 activity by activation of proteinase-activated-receptor 2 (PAR-2), interleukin 1, leptin, or prostaglandin E2;and 2) Using gene-targeted mice, to determine the effects of inducible, cartilage-specific ..
  43. Development of a mouse model of obesity in pregnancy
    Thomas Jansson; Fiscal Year: 2009
    ..be performed and blood samples obtained to characterize animals metabolically (serum concentrations of insulin, leptin, TNF-?, IL-6, and adiponectin)...
  44. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2010
    ..insulin, glucose, HOMA-IR, fasting lipids;growth hormones: insulin-like growth factor (IGF-I);adipocyte markers: leptin, adiponectin;and inflammatory markers: C-reactive protein (CRP), lnterleukin-6 (IL-6), and tumor necrosis factor (..
  45. Vitamin D and Vascular Function in Obese Children
    Kumaravel Rajakumar; Fiscal Year: 2013
    ..g. CRP, IL-6, TNF-alpha);(6) adipokines (leptin and adiponectin);and (7) nitric oxide metabolites. Brachial FMD at 6 months will be the primary outcome measure...
  46. Extending Sleep in Obese Adults to Promote Weight Loss
    Ann E Rogers; Fiscal Year: 2010
    ..glucose levels and blood pressure in healthy obese individuals;and 4) explore the effect of sleep extension on leptin and ghrelin levels...
  47. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2012
    ..In vitro adiponectin treated hepatic stellate cells (HSCs) block leptin-mediated signal transduction that leads to pro- fibrogenic responses in culture and, this inhibitory activity ..
  48. Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular Risk
    Sheila Gahagan; Fiscal Year: 2012
    ..In addition, we will measure anthropometry, fat and muscle mass (DXA), fasting glucose, insulin (HOMA IR), lipids, leptin, ghrelin, adiponectin, orexin, CRP, and TNF alpha...
  49. Immunology, Inflammation, and Endometriosis
    STACEY ANN MISSMER; Fiscal Year: 2012
    ..Specifically, a) Higher endogenous levels of c-peptide, insulin, leptin, and lower levels of adiponectin increase the risk of endometriosis...
  50. Multiple Molecular Mechanisms for Adiponectin Therapy in Hepatic Fibrogenesis
    Frank A Anania; Fiscal Year: 2013
    ..Our work in the prior funding period focused on the role of two key adipocytokines-leptin and adiponectin-in which we have convincingly demonstrated that leptin is clearly a pro-fibrogenic cytokine while ..
  51. Maternal Dietary Patterns and Child Weight Status
    Chantel L Martin; Fiscal Year: 2013
    ..patterns during pregnancy and maternal nutrient biomarkers of fetal environment including glucose, insulin, leptin, triglycerides, and total cholesterol;(2) to examine the relationship between maternal dietary patterns during ..
  52. Lactation and Incidence of Diabetes Mellitus in CARDIA Women
    ERICA PAULINE GUNDERSON; Fiscal Year: 2013
    ..metabolic risk factors, and biomarkers of insulin resistance and adiposity (adiponectin, IL-6, CRP, sICAM-1, leptin, sOB-R, TNF-1) that precede the onset of diabetes in women...
  53. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Furthermore, we observed increased plasma leptin, corticosterone, aldosterone and renin activity in MS rats...
  54. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Furthermore, we observed increased plasma leptin, corticosterone, aldosterone and renin activity in MS rats...
  55. Sleep Disordered Breathing and Growth in Children: A Longitudinal Cohort Study
    Karen Bonuck; Fiscal Year: 2009
    ..Growth Biomarkers, &Growth We will analyze: a) the association between plasma insulin-like growth factors, leptin levels, dietary intake, and SDB, and;b) the effects of these biomarkers and SDB, and their interactions on growth...
  56. CONTROL OF GONADOTROPIN SECRETION DURING LACTATION
    Kevin L Grove; Fiscal Year: 2013
    ..is the critical factor linking energy balance and suppressed GnRH, our recent studies demonstrate that restoring leptin to normal physiological levels does not reverse the inhibition of kisspeptin r GnRH in either lactation or caloric ..
  57. Neonatal Programming of Growth and Maturation in Rhesus Monkeys
    Andrew Muir; Fiscal Year: 2013
    ..of metabolically dysregulated adipose tissue, including insulin resistance (HOMA-IR, glucose clamp), circulating leptin and adiponectin, and markers of chronic inflammation (CRP, IL-6, TNF-[unreadable])...
  58. Randomized Trial of a Postpartum Diabetes Prevention Program for Hispanic Women
    Lisa Chasan-Taber; Fiscal Year: 2013
    ..e., glucose, insulin, HbA1c, leptin, TNF-, HOMA, AUCgluc, adiponectin), 3) other cardiovascular risk factors (i.e...
  59. Exploring the Impact of Negative Energy Balance in Men with Prostate Cancer
    Wendy Demark-Wahnefried; Fiscal Year: 2013
    ..g., leptin, vascular endothelial growth factor (VEGF), phosphatidylinositol 3 kinase (PI3K), and the mammalian target of ..
  60. Fatty acid desaturase activity, fish oil and colorectal cancer chemoprevention
    Harvey J Murff; Fiscal Year: 2013
    ..mucosal tissue levels of fatty acids, and changes in biomarkers of inflammation (C-reactive protein), adipokines (leptin, adiponectin), and markers of insulin sensitivity...
  61. DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASE
    Frank B Hu; Fiscal Year: 2013
    ..the long-term relationships between change in diet quality and changes in biomarkers of the brain-adipose axis (leptin, soluble leptin receptor (sOB-R), insulin, adiponectin, retinol binding protein 4 [RBP4], tumor necrosis factor ..
  62. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adipocyte leptin has been considered as "permissive" for normal reproduction;however, its exact role is uncertain...
  63. Changes in Adipokines and Adiposity during Puberty and Young Adulthood
    NICOLE LENORE MIHALOPOULOS; Fiscal Year: 2013
    ..Specifically, she will study how adiponectin and leptin, two adipokines that affect insulin resistance and lipid metabolism, and brown adipose tissue (BAT) activity ..
  64. Investigating the role of leptin in larval growth and limb development in Xenopus
    ERICA CRESPI; Fiscal Year: 2009
    The main objective of the proposed project is to determine the role of the energy balance hormone leptin on early developmental processes, including limb bud growth and differentiation, in the South African clawed frog (Xenopus laevis)...
  65. The Role of Leptin in Placental Development
    Laura Schulz; Fiscal Year: 2009
    ..The hypothesis underlying this proposal is that the hormone leptin influences multiple steps in the process of placental development...
  66. Molecular Mechanisms Mediating Resistance to Leptin Signaling During Fat Gain
    Virend Somers; Fiscal Year: 2009
    ..There has been increasing interest in the role leptin, a peripheral circulating satiety factor, which plays a key role in balancing energy expenditure and preventing ..
  67. Adiponectin effects on leptin signaling in hepatocellular carcinoma
    Neeraj Kumar Saxena; Fiscal Year: 2011
    ..affects hepatocellular carcinogenesis by autocrine and paracrine actions mediated by two major adipocytokines, leptin and adiponectin...
  68. Leptin Production and Action in Adipocytes
    Yiying Zhang; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Leptin plays a critical role in regulating systemic energy balance...
  69. LEPTIN ACTION ON HYPOTHALAMIC PEPTIDES GOVERNING FEEDING
    Abhiram Sahu; Fiscal Year: 2001
    The goal of this project is to understand the neurobiological basis of food intake and body weight regulation. Leptin, a product of the obese gene in fat cells, is one of the most important peripheral satiety factors that inhibits food ..
  70. Significance of Pituitary Leptin to Gonadotropes
    Gwen V Childs; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Pituitary leptin changes in a cyclic manner that indicates it may facilitate or permit the secretion of gonadotropins...
  71. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010
    ..b>Leptin is hormone produced by adipose tissue that is reduced in the energy malnourished and is known to regulate innate ..
  72. Hindbrain Actions of Leptin
    Gerlinda E Hermann; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Leptin is a peptide hormone produced by adipose tissue and released in proportion to adipose mass...
  73. Development of Leptin-Sensitive Hypothalamic Pathways
    Richard B Simerly; Fiscal Year: 2010
    The long-range goal of this research is to understand how the adipocyte-derived hormone leptin acts on hypothalamic neurons to regulate development of central neural pathways involved in the regulation of mammalian homeostasis...
  74. ROLE OF LEPTIN IN WOUND ANGIOGENESIS
    MARIA SIERRA HONIGMANN; Fiscal Year: 2006
    ..Among these angiogenic factors, the P.I. has identified the pleiotropic cytokine leptin as an important member of this repertoire and subsequently established that expression of the leptin gene is ..
  75. Advances in the pathogenesis of non-thyroidal illness
    Patrizio Caturegli; Fiscal Year: 2009
    ..More recently we found that leptin, in addition to mast cells, is involved in the pathogenesis of bacterial NTI...
  76. Effects of Leptin on Body Weight and Neuroendocrine Axes after Gastric Bypass
    Judith Korner; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): This is a pilot and feasibility study to examine a novel intervention using leptin in weight-reduced individuals who have undergone bariatric surgery but still remain obese...
  77. LEPTIN & NEUROPEPTIDE-Y ALTERS FETAL SWALLOWING ACTIVITY
    Michael Ross; Fiscal Year: 2002
    ..Two potential candidates for ingestive behavior regulation are leptin and neuropeptide-Y (NPY)...
  78. Fructose vs Glucose: Leptin, Appetite and Food Intake
    Peter Havel; Fiscal Year: 2002
    ..Whereas glucose stimulates insulin and leptin production, fructose does not...