corticotropin releasing hormone

Summary

Summary: A neuropeptide of about 41 amino acids released by the HYPOTHALAMUS that stimulates the release of CORTICOTROPIN by the ANTERIOR PITUITARY GLAND.

Top Publications

  1. ncbi Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
    W Vale
    Science 213:1394-7. 1981
  2. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
  3. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
  4. ncbi CRF and CRF receptors: role in stress responsivity and other behaviors
    Tracy L Bale
    Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6046, USA
    Annu Rev Pharmacol Toxicol 44:525-57. 2004
  5. ncbi Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:47-54. 2007
  6. ncbi Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
    T L Bale
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA
    Nat Genet 24:410-4. 2000
  7. pmc Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
    T M Reyes
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:2843-8. 2001
  8. ncbi Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance
    A Makrigiannakis
    School of Medicine, University of Crete, Heraklion 71110, Greece
    Nat Immunol 2:1018-24. 2001
  9. pmc CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:17198-203. 2007
  10. ncbi Corticotropin-releasing factor inhibits maternal aggression in mice
    Stephen C Gammie
    Neuroscience Training Program, Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Behav Neurosci 118:805-14. 2004

Detail Information

Publications340 found, 100 shown here

  1. ncbi Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
    W Vale
    Science 213:1394-7. 1981
  2. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..Further elucidation of the biochemical and molecular mechanisms involved in GR changes in major depression is an exciting frontier that will no doubt lead to new insights into the pathophysiology and treatment of affective disorders...
  3. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
    ..These mechanisms, determined in rats, may explain some of the epidemic of obesity occurring in our society...
  4. ncbi CRF and CRF receptors: role in stress responsivity and other behaviors
    Tracy L Bale
    Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6046, USA
    Annu Rev Pharmacol Toxicol 44:525-57. 2004
    ..The development of disorders related to heightened stress sensitivity and dysregulation of stress-coping mechanisms appears to involve regulatory mechanisms of CRF family members...
  5. ncbi Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:47-54. 2007
    Exaggerated corticotropin (ACTH) and cortisol response to the combined dexamethasone (DEX)/corticotropin releasing hormone (CRH) test, indicating impaired regulation of the hypothalamus-pituitary-adrenocortical (HPA) system, is ..
  6. ncbi Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
    T L Bale
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA
    Nat Genet 24:410-4. 2000
    ..Mutant mice have normal basal feeding and weight gain, but decreased food intake following food deprivation. Intravenous Ucn produces no effect on mean arterial pressure in the mutant mice...
  7. pmc Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
    T M Reyes
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:2843-8. 2001
    ..Initial functional studies are consistent with Ucn II involvement in central autonomic and appetitive control, but not in generalized behavioral activation...
  8. ncbi Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance
    A Makrigiannakis
    School of Medicine, University of Crete, Heraklion 71110, Greece
    Nat Immunol 2:1018-24. 2001
    ..These findings suggested that locally produced CRH promotes implantation and maintenance of early pregnancy primarily by killing activated T cells...
  9. pmc CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:17198-203. 2007
    ..Overactivation of the CRF-CRF(1) system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction...
  10. ncbi Corticotropin-releasing factor inhibits maternal aggression in mice
    Stephen C Gammie
    Neuroscience Training Program, Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Behav Neurosci 118:805-14. 2004
    ..These findings suggest that decreased CRF is necessary for maternal aggression and may act by altering brain activity in response to an intruder...
  11. ncbi The CRF peptide family and their receptors: yet more partners discovered
    Frank M Dautzenberg
    Therapeutic Applications, Axovan, Innovation Center, Gewerbestrasse 16, 4123, Allschwil, Switzerland
    Trends Pharmacol Sci 23:71-7. 2002
    ....
  12. ncbi Effects of urocortin 2 and 3 on motor activity and food intake in rats
    Hisayuki Ohata
    Department of Physiology, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo 113 8602, Japan
    Peptides 25:1703-9. 2004
    ..These results suggest that the CRF2 receptor is involved in motor suppressive effects as well as anxiolytic and anorectic effects of Ucn 2 and Ucn 3...
  13. ncbi The measurement of maternal plasma corticotropin-releasing factor (CRF) and CRF-binding protein improves the early prediction of preeclampsia
    P Florio
    Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    J Clin Endocrinol Metab 89:4673-7. 2004
    ..75% when both CRF and CRF-BP levels were changed, and 0% if both hormone markers were unaltered. The measurement of CRF and CRF-BP levels may add significant prognostic information for predicting PE in at-risk pregnant women...
  14. pmc Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
    K Lewis
    Clayton Foundation Laboratories for Peptide Biology and Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:7570-5. 2001
    ..Urocortin III is selective for type 2 CRF receptors and thus represents another potential endogenous ligand for these receptors...
  15. pmc Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih
    M J Wanat
    Ernest Gallo Clinic and Research Center, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
    J Physiol 586:2157-70. 2008
    ....
  16. ncbi Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
    J Vaughan
    Clayton Foundation Laboratories for Peptide Biology, La Jolla, California, USA
    Nature 378:287-92. 1995
    ....
  17. ncbi Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation
    Shin Fukudo
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2 1 Seiryo, Aoba, Sendai, 980 8575, Japan
    J Gastroenterol 42:48-51. 2007
    ..These findings suggest the major role of CRH in stress-related pathophysiology of IBS and possibly in inflammation of the intestinal mucosa...
  18. ncbi Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness
    James P Herman
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Front Neuroendocrinol 24:151-80. 2003
    ..Imbalances among these limbic pathways and homeostatic sensors are likely to underlie hypothalamo-pituitary-adrenocortical dysfunction associated with numerous disease processes...
  19. ncbi Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
    Marianne B Muller
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, Munich 80804, Germany
    Nat Neurosci 6:1100-7. 2003
    ..Furthermore, we provide evidence for a new role of limbic Crhr1 in neuroendocrine adaptation to stress...
  20. ncbi The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
    F Holsboer
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychiatr Res 33:181-214. 1999
    ..Thus, patients with clinical conditions that are causally related to HPA hyperactivity may profit from treatment with a CRH1 receptor antagonist...
  21. ncbi Corticotropin-releasing hormone (CRH) as a regulator of waking
    F C Chang
    Neuroscience Laboratory, Department of Neurology, China Medical College Hospital, Taichung, Taiwan
    Neurosci Biobehav Rev 25:445-53. 2001
    ....
  22. ncbi Assessment of the dexamethasone/CRH test as a state-dependent marker for hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depressive episode: a Multicenter Study
    Hiroshi Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Neuropsychopharmacology 31:212-20. 2006
    ..Restoration from HPA axis abnormalities occurred with clinical responses to treatment, particularly in depressed patients who underwent ECT...
  23. ncbi Reproductive corticotropin releasing hormone, implantation, and fetal immunotolerance
    Sophia N Kalantaridou
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Ioannina Medical School, Ioannina, Greece
    Crit Rev Clin Lab Sci 44:461-81. 2007
    ..CRH antagonists have been used experimentally to elucidate the role of CRH in blastocyst implantation and invasion, early fetal immunotolerance, and premature labor...
  24. ncbi Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress
    Sayamwong E Hammack
    Department of Psychiatry, Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA 30322, USA
    Behav Brain Res 147:55-64. 2003
    ..In a separate experiment, the effective dose of CRH blocked the usual behavioral consequences of uncontrollable stress...
  25. ncbi Restraint stress and corticotropin releasing hormone modulation of murine cutaneous POMC mRNA
    Melanie S Flint
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Stress 6:59-62. 2003
    ..In the studies presented here, we tested mild, acute restraint stress activation of the cutaneous corticotropin releasing hormone-pro-opiomelanocortin (CRH-POMC) axis...
  26. ncbi Corticotropin-releasing factor and behavior
    G F Koob
    Fed Proc 44:259-63. 1985
    ..These results suggest that CRF liberated directly into the central nervous system may have a neurotropic action important for mobilizing behavioral responses to stress...
  27. pmc Intratumoral CRH modulates immuno-escape of ovarian cancer cells through FasL regulation
    V Minas
    Laboratory of Human Reproduction, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Crete, Heraklion 71003, Greece
    Br J Cancer 97:637-45. 2007
    ..These findings support the hypothesis that CRHR1 antagonists could potentially be used against ovarian cancer...
  28. pmc Prolactin activates mitogen-activated protein kinase signaling and corticotropin releasing hormone transcription in rat hypothalamic neurons
    Annegret Blume
    Department of Behavioural and Molecular Neuroendocrinology, Institute of Zoology, University of Regensburg, 93053 Regensburg, Germany
    Endocrinology 150:1841-9. 2009
    ..In addition, the prominent stimulatory action of PRL on the ERK/MAPK pathway in the hypothalamic PVN and supraoptic nucleus is likely to mediate neuroplasticity of the neuroendocrine system during lactation...
  29. ncbi Elevated corticotropin releasing hormone/corticotropin releasing hormone-R1 expression in postmortem brain obtained from children with generalized epilepsy
    W Wang
    Department of Paediatrics, Kingston General Hospital, Ontario, Canada
    Ann Neurol 50:404-9. 2001
    The corticotropin releasing hormone (CRH) system has been suggested to initiate seizure activity in the developing brain. However, human data to support this theory is lacking...
  30. ncbi Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors
    Sharla F Young
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, CRC 1 3330, 10 Center Drive, MSC 1103, Bethesda, MD 20892 1103, USA
    Cell Mol Neurobiol 27:439-61. 2007
    ..Regulated expression and interaction of pituitary VP V1b receptor (V1bR) and corticotropin releasing hormone receptor type 1 (CRHR1) are critical for hypothalamic pituitary adrenal (HPA) axis adaptation, but it ..
  31. ncbi Sexually dimorphic responses of the brain norepinephrine system to stress and corticotropin-releasing factor
    Andre L Curtis
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:544-54. 2006
    ..These sex differences in the CRF regulation of the LC-NE system translate to a differential response to stress and may play a role in the increased vulnerability of females to stress-related psychiatric disorders...
  32. ncbi Repeated antenatal glucocorticoid treatment decreases hypothalamic corticotropin releasing hormone mRNA but not corticosteroid receptor mRNA expression in the fetal guinea-pig brain
    L McCabe
    Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada
    J Neuroendocrinol 13:425-31. 2001
    ..In this study, we hypothesized that such treatment modifies corticotropin releasing hormone (CRH), glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) systems in the developing ..
  33. ncbi Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress
    Norman Pecoraro
    Department of Physiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0444
    Endocrinology 145:3754-62. 2004
    ..The results of this experiment tend to support our model of chronic effects of stress and GCs, showing a stressor-induced preference for comfort food, and a comfort-food reduction in activity of the HPA axis...
  34. ncbi Corticotropin releasing hormone: a diagnostic marker for behavioral and reproductive disorders?
    Pasquale Florio
    Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    Front Biosci 12:551-60. 2007
    ..The CRH released by the placenta is measurable in maternal plasma and other biological fluids and may be used to diagnose subclinical processes anteceding pregnancy complications such as pre-eclampsia and preterm delivery...
  35. ncbi Multiple feedback mechanisms activating corticotropin-releasing hormone system in the brain during stress
    Shinya Makino
    Second Department of Internal Medicine, Kochi Medical School, Okoh cho, Nankoku, Japan
    Pharmacol Biochem Behav 73:147-58. 2002
    ..Effects of tricyclic antidepressants (TCAs), which appear to mitigate the above mentioned multiple feedback loop forming the vicious circle to activate central CRH systems, will also be discussed...
  36. pmc Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome
    Y Sagami
    Department of Psychosomatic Medicine, Tohoku University School of Medicine, Sendai, Japan
    Gut 53:958-64. 2004
    b>Corticotropin releasing hormone (CRH) is a major mediator of the stress response in the brain-gut axis. Irritable bowel syndrome (IBS) is presumed to be a disorder of the brain-gut link associated with an exaggerated response to stress...
  37. pmc Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates
    K E Habib
    Clinical Neuroendocrinology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 97:6079-84. 2000
    ....
  38. ncbi Structural determinants critical for localization and signaling within the seventh transmembrane domain of the type 1 corticotropin releasing hormone receptor: lessons from the receptor variant R1d
    Danijela Markovic
    Endocrinology and Metabolism, Clinical Sciences Institute, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 22:2505-19. 2008
    ..This mechanism appears to involve accelerated CRH-R2beta endocytosis...
  39. ncbi Urocortin III is expressed in pancreatic beta-cells and stimulates insulin and glucagon secretion
    Chien Li
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Endocrinology 144:3216-24. 2003
    ..Taken together, the present studies suggest pancreatic Ucn III acting through CRFR2 is involved in the local regulation of glucagon and insulin secretion...
  40. pmc Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis
    Chien Li
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:4206-11. 2007
    ....
  41. ncbi The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology
    Edward W Hillhouse
    The Leeds Institute of Genetics, Health and Therapeutics, The University of Leeds, Leeds LS2 9NL, UK
    Endocr Rev 27:260-86. 2006
    ..The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease...
  42. ncbi Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation
    Stephen C Heinrichs
    The Scripps Research Institute, Department of Neuropharmacology, CVN 7, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 311:427-40. 2004
    ..A conceptual framework is provided for extrapolation of animal model findings to humans and for viewing CRF/urocortin activation as a continuum measure linking normal and pathological states...
  43. ncbi When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Psychiatry 160:1554-65. 2003
    ....
  44. ncbi Nuclear receptor coregulators differentially modulate induction and glucocorticoid receptor-mediated repression of the corticotropin-releasing hormone gene
    S van der Laan
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research and Leiden University Medical Centre, 2300 RA, Leiden, The Netherlands
    Endocrinology 149:725-32. 2008
    ..We conclude that modulation of coregulator activity may play a role in the control of the hypothalamus-pituitary-adrenal axis...
  45. ncbi Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
    L Muglia
    Division of Endocrinology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Nature 373:427-32. 1995
    ..Postnatally, despite marked glucocorticoid deficiency, these mice exhibit normal growth, fertility and longevity, suggesting that the major role of glucocorticoid is during fetal rather than postnatal life...
  46. ncbi Urocortin III-immunoreactive projections in rat brain: partial overlap with sites of type 2 corticotrophin-releasing factor receptor expression
    Chien Li
    The Clayton Foundation Laboratories for Peptide Biology and Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 22:991-1001. 2002
    ..These results also suggest that Ucn III is positioned to play a role in mediating physiological functions, including food intake and neuroendocrine regulation...
  47. ncbi The role of corticotropin-releasing factor in drug addiction
    Z Sarnyai
    Laboratory of Neuroendocrinology and Laboratory of Biology of Addictive Diseases, Rockefeller University, New York, New York, USA
    Pharmacol Rev 53:209-43. 2001
    ..These preclinical data may provide a rationale for the development of CRF-based pharmacotherapies for the treatment of compulsive drug use in humans...
  48. ncbi Alcoholism: allostasis and beyond
    George F Koob
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 27:232-43. 2003
    ....
  49. ncbi Morphine and cocaine influence on CRF biosynthesis in the rat central nucleus of amygdala
    M Maj
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, PL 31 343, Krakow, Poland
    Neuropeptides 37:105-10. 2003
    ....
  50. ncbi Corticotropin-releasing hormone (CRH) and immunotolerance of the fetus
    Antonis Makrigiannakis
    Laboratory of Pharmacology, School of Medicine, University of Crete, Heraklion 71110, Greece
    Biochem Pharmacol 65:917-21. 2003
    ..Furthermore, CRH increases the apoptosis of activated T lymphocytes through FasL induction, participating in the processes of both implantation and early pregnancy tolerance...
  51. ncbi CRF signaling: molecular specificity for drug targeting in the CNS
    Eduardo Arzt
    Laboratorio de Fisiologia y Biologia Molecular, Departamento Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales FCEN, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
    Trends Pharmacol Sci 27:531-8. 2006
    ..This intracellular and neuroanatomical signaling specificity will facilitate the search for less pleiotropic antagonists and new chemical compounds that modulate signal transduction in a site-specific manner...
  52. ncbi Involvement of central amygdalar and bed nucleus of the stria terminalis corticotropin-releasing factor in behavioral responses to social defeat
    Aaron M Jasnow
    Center for Behavioral Neuroscience and Georgia State University, Atlanta, GA 30303, USA
    Behav Neurosci 118:1052-61. 2004
    ..These data suggest that CRF acts within a neural circuit that includes the amygdala and the BNST to modulate agonistic behavior following social defeat...
  53. ncbi The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress
    T Deak
    Department of Psychology, University of Colorado, Boulder 80309 0345, USA
    Endocrinology 140:79-86. 1999
    ..Despite the marked behavioral effects observed in antalarmin-treated rats, antalarmin had no effect on IS-induced rises in ACTH or corticosterone. However, antalarmin did block the ACTH response produced by exposure to 2 footshocks...
  54. pmc Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats
    Cindy K Funk
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 61:78-86. 2007
    ..Here, we used an animal model of ethanol dependence to test the effects of CRF(1) receptor antagonists on excessive ethanol self-administration in dependent rats...
  55. pmc Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 99:13908-13. 2002
    ..These findings indicate that activation of CRH receptors in the BLA, likely by training-induced release of endogenous peptide originating from the CEA, participates in mediating stress effects on memory consolidation...
  56. ncbi Brain circuits involved in corticotropin-releasing factor-norepinephrine interactions during stress
    A J Dunn
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, P O Box 33932, Shreveport, LA 71130 3932, USA
    Ann N Y Acad Sci 1018:25-34. 2004
    ..Further investigations are necessary to establish the validity or otherwise of the feed-forward hypothesis...
  57. pmc Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors
    David H Overstreet
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, 3009 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 77:405-13. 2004
    ..These findings indicate that the CRF system and CRF(1) receptors play key roles in the adaptive change responsible for the anxiety-like behavior induced by repeated withdrawals from chronic ethanol...
  58. ncbi Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
    T Kishimoto
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Nat Genet 24:415-9. 2000
    ..Both respond with increased edema formation in response to thermal exposure, however, indicating that in contrast to its central role in anxiety, the peripheral role of Crhr2 in vascular permeability is independent of gender...
  59. ncbi Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking
    Bin Wang
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 25:5389-96. 2005
    ..Similar neuroadaptations may be important for the comorbidity between addiction and other stress-related psychiatric disorders...
  60. ncbi Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation
    G Aguilera
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bldg 10, Rm 10N262, 10 Center Drive MSC 1862, Bethesda, MD 20892 1862, USA
    Regul Pept 96:23-9. 2000
    ..vasopressin (VP) regulates pituitary ACTH secretion by potentiating the stimulatory effects of corticotropin releasing hormone (CRH)...
  61. ncbi Neurochemical regulation of sleep
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:537-52. 2007
    ....
  62. ncbi Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder
    D G Baker
    Psychiatry Service, Cincinnati Veterans Affairs Medical Center and the Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45220, USA
    Neuroimmunomodulation 9:209-17. 2001
    ..The purpose of this study was to assess the relation of IL-6 levels and hypothalamic-pituitary-adrenal and noradrenergic activity in patients with well-characterized PTSD...
  63. ncbi Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
    David L Walker
    Department of Psychiatry and Behavioral Sciences and The Center for Behavioral Neuroscience, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Eur J Pharmacol 463:199-216. 2003
    ....
  64. ncbi Role of the extended amygdala in short-duration versus sustained fear: a tribute to Dr. Lennart Heimer
    David L Walker
    Yerkes National Primate Center and the Center for Behavioral Neuroscience, Emory University, 954 Gatewood Drive, Atlanta, GA 30329, USA
    Brain Struct Funct 213:29-42. 2008
    ..We hypothesize this occurs because the CeA(L) releases the peptide corticotropin releasing hormone (CRF) into the BNST(L) which facilitates the release of glutamate from BLA terminals...
  65. ncbi Anticipatory cues differentially provoke in vivo peptidergic and monoaminergic release at the medial prefrontal cortex
    Zul Merali
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Neuropsychopharmacology 29:1409-18. 2004
    ..The activity of DA and 5-HT neurons, in contrast, is more closely aligned with the cognitive appraisal of predictor stimuli...
  66. ncbi Single administration of interleukin-1 increased corticotropin releasing hormone and corticotropin releasing hormone-receptor mRNA in the hypothalamic paraventricular nucleus which paralleled long-lasting (weeks) sensitization to emotional stressors
    E D Schmidt
    Graduate School Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, Medical Pharmacology, VUMC, Van der Boechorststraat 7, Amsterdam 10 81 BT, The Netherlands
    Neuroscience 116:275-83. 2003
    ....
  67. ncbi Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress
    S C Coste
    Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR, USA
    Peptides 22:733-41. 2001
    ..Together these models provide new insights into the role of CRH pathways in promoting stability through adaptive changes, a process known as allostasis...
  68. ncbi Urocortin promotes hemodynamic and bioenergetic recovery and improves cell survival in the isolated rat heart exposed to ischemia/reperfusion
    Tiziano M Scarabelli
    Medical Molecular Biology Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, London, United Kingdom
    J Am Coll Cardiol 40:155-61. 2002
    ..This study evaluates the hemodynamic, bioenergetic and cytoprotective effects of urocortin (Ucn) in the isolated rat heart exposed to ischemia (I)/reperfusion (R)...
  69. ncbi Corticotropin releasing hormone receptors: two decades later
    Greti Aguilera
    Section of Endocrine Physiology, Develomental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Peptides 25:319-29. 2004
    Hypothalamic corticotropin releasing hormone (CRH) regulates pituitary ACTH secretion and mediates behavioral and autonomic responses to stress, through interaction with type 1 plasma membrane receptors (CRHR1) located in pituitary ..
  70. pmc Cyclic adenosine 3',5'-monophosphate responsive element binding protein phosphorylation is required but not sufficient for activation of corticotropin-releasing hormone transcription
    Ying Liu
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Endocrinology 149:3512-20. 2008
    ..In addition, the data indicate that phosphorylated CREB is essential but not sufficient for activation of CRH transcription, suggesting that full promoter stimulation requires the interaction of phosphorylated CREB with a coactivator...
  71. pmc Acute stress modulates the histamine content of mast cells in the gastrointestinal tract through interleukin-1 and corticotropin-releasing factor release in rats
    Helene Eutamene
    Institut National de la Recherche Agronomique, Department of Neurogastroenterology and Nutrition, 180 chemin de Tournefeuille, BP 3, 31931 Toulouse, France
    J Physiol 553:959-66. 2003
    ..C.V. CRF administration. These results suggest that in rats acute stress increases colonic mast cell histamine content. This effect is mediated by the release in cascade in the brain first of IL-1 and secondly of CRF...
  72. ncbi Novel glucocorticoid and cAMP interactions on the CRH gene promoter
    Bruce R King
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Newcastle, NSW 2310, Australia
    Mol Cell Endocrinol 194:19-28. 2002
    ..Tissue specific expression of transcription factors may mediate regulation of the CRH gene...
  73. ncbi Lesion of central part of the dorsomedial nucleus alters vasopressin but not corticotropin releasing hormone mRNA levels in rat hypothalamic paraventricular nucleus
    A Kiss
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia
    Gen Physiol Biophys 20:393-400. 2001
    ..The rise in CRH mRNA levels after osmotic stress was potentiated in DMN lesioned animals. Thus, the DMN participates in the control of hypothalamic peptide gene expression and pituitary adrenocorticotropic function...
  74. pmc Beta-endorphin neuronal cell transplant reduces corticotropin releasing hormone hyperresponse to lipopolysaccharide and eliminates natural killer cell functional deficiencies in fetal alcohol exposed rats
    Nadka I Boyadjieva
    Endocrine Program, Department of Animal Sciences, Rutgers The State University of New Jersey, New Brunswick, NJ 08901, USA
    Alcohol Clin Exp Res 33:931-7. 2009
    Natural killer (NK) cell dysfunction is associated with hyperresponse of corticotropin releasing hormone (CRH) to immune challenge and with a loss of beta-endorphin (BEP) neurons in fetal alcohol exposed animals...
  75. ncbi Amygdaloid corticotropin-releasing factor targets locus coeruleus dendrites: substrate for the co-ordination of emotional and cognitive limbs of the stress response
    E J van Bockstaele
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Neuroendocrinol 10:743-57. 1998
    ..This cellular substrate for amygdaloid-CRF modulation of brain noradrenergic activity may serve as a mechanism for the integration of emotional and cognitive responses to stress...
  76. ncbi Brain mechanisms underlying emotional alterations in the peripartum period in rats
    Inga D Neumann
    Institute of Zoology, University of Regensburg, Regensburg, Germany
    Depress Anxiety 17:111-21. 2003
    ..Both brain oxytocin and prolactin, highly activated at this time, play a significant role in these behavioral and possibly also neuroendocrine adaptations in the peripartum period...
  77. ncbi Chronic stress and comfort foods: self-medication and abdominal obesity
    Mary F Dallman
    Department of Physiology and Program in Neurosciences, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Brain Behav Immun 19:275-80. 2005
    ..A signal associated with this fat depot appears, as with eating "comfort foods," to reduce the influence of the chronic stress network on behaviors, autonomic, and neuroendocrine outflow...
  78. pmc Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency
    M Venihaki
    Division of Endocrinology, Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:7336-41. 2000
    ....
  79. ncbi Agonist-induced internalization of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleus
    Beverly A S Reyes
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, PA 19107, USA
    Eur J Neurosci 23:2991-8. 2006
    ..This process may be a pivotal target by which stressors or pharmacological agents regulate the sensitivity of the LC-NE system to CRF and subsequent stressors...
  80. ncbi Sucrose ingestion normalizes central expression of corticotropin-releasing-factor messenger ribonucleic acid and energy balance in adrenalectomized rats: a glucocorticoid-metabolic-brain axis?
    K D Laugero
    Department of Physiology, University of California San Francisco, San Francisco, California 94143 0444, USA
    Endocrinology 142:2796-804. 2001
    ....
  81. ncbi A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
    G F Koob
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 848:141-52. 1999
    ....
  82. pmc Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neurons
    Beverly A S Reyes
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
    Endocrinology 149:122-30. 2008
    ....
  83. ncbi Overexpression of corticotropin-releasing hormone in transgenic mice and chronic stress-like autonomic and physiological alterations
    Anneloes Dirks
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Eur J Neurosci 16:1751-60. 2002
    ....
  84. pmc Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH
    S C Weninger
    Program in Neuroscience, Howard Hughes Medical Institute, Children s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:8283-8. 1999
    ....
  85. ncbi Nibbling at CRF receptor control of feeding and gastrocolonic motility
    Eric P Zorrilla
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Pharmacol Sci 24:421-7. 2003
    ..These findings have important physiological implications and suggest targeted approaches for the pharmacotherapy of obesity and stress-related functional gastrointestinal and eating disorders...
  86. ncbi Reduction of stress-induced behavior by antagonism of corticotropin-releasing hormone 2 (CRH2) receptors in lateral septum or CRH1 receptors in amygdala
    Vaishali P Bakshi
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    J Neurosci 22:2926-35. 2002
    ..CRH2 receptors may thus represent a potential target for the development of novel CRH system anxiolytics...
  87. ncbi Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes
    M E Quevedo
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    In Vitro Cell Dev Biol Anim 37:50-4. 2001
    ..Therefore, similar to its central actions, cutaneous CRH may also he involved in the stress response, but at a highly localized level...
  88. ncbi Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin
    A Slominski
    Department of Pathology and Laboratory Medicine, Albany Medical College, NY 12208, USA
    FEBS Lett 374:113-6. 1995
    ..skin, the largest body organ exposed to multiple stressors, expresses proopiomelanocortin (POMC), corticotropin releasing hormone (CRH) and CRH-receptor (CRHR) genes in vivo...
  89. ncbi Ethanol modulates corticotropin releasing hormone release from the rat hypothalamus: does acetaldehyde play a role?
    Carla Cannizzaro
    Department of Pharmacological Sciences P Benigno, University of Palermo, Palermo, Italy
    Alcohol Clin Exp Res 34:588-93. 2010
    ..3 x 10(3) microM) an ACD-trapping agent. CRH levels were evaluated by a radioimmunoassay...
  90. ncbi Development of a corticotropin-releasing factor-mediated effect on the firing rate of Purkinje cells in the postnatal mouse cerebellum
    Georgia A Bishop
    Department of Neuroscience, The Ohio State University, Columbus, 43210, USA
    Exp Neurol 178:165-74. 2002
    ....
  91. pmc Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress
    Y Chen
    Departments of Anatomy Neurobiology and Pediatrics, ZOT 4475, University of California at Irvine, Irvine, CA 92697 4475, USA
    Neuroscience 126:533-40. 2004
    ..The stress-associated neuropeptide corticotropin releasing hormone (CRH) is expressed in inhibitory interneurons of rodent hippocampus, yet physiological and ..
  92. ncbi Corticotropin releasing hormone--a GPCR drug target
    C F Hemley
    Department of Chemistry, University of Wollongong, Wollongong, NSW, 2522, Australia
    Curr Drug Targets 8:105-15. 2007
    ..Thus, an extensive number of both CRH peptide analogues and small ligands that show nanomolar antagonism have been developed with SAR libraries being integral to the iterative drug design process...
  93. ncbi Corticotropin releasing factor in the embryonic mouse cerebellum
    G A Bishop
    Department of Neuroscience, The Ohio State University, Columbus 43210, USA
    Exp Neurol 160:489-99. 1999
    ..The presence of this peptide at this critical stage of cerebellar development and its continued expression throughout the postnatal period of ontogeny suggests that CRF may play an important developmental role...
  94. ncbi Corticotropin releasing hormone stimulates proliferation of keratinocytes
    T Mitsuma
    Department of Dermatology, Nagoya University, Graduate School of Medicine, Aichi, Japan
    Life Sci 69:1991-8. 2001
    b>Corticotropin releasing hormone (CRH) is a potent mediator of stress responses and stress-induced disorders...
  95. ncbi Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3)
    N C Vamvakopoulos
    Department of Biology, University of Thessaly School of Medicine, Larisa, Greece
    Genomics 25:325-7. 1995
  96. ncbi Urocortin and corticotropin-releasing factor receptor expression in normal cycling human ovaries
    Y Muramatsu
    Department of Pathology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 86:1362-9. 2001
    ..These results suggest that urocortin is locally synthesized in steroidogenic luteal cells and acts on them as an autocrine and/or paracrine regulator of ovarian steroidogenesis, especially during luteal regression...
  97. ncbi Corticotropin releasing hormone (CRH) gene variation: comprehensive resequencing for variant and molecular haplotype discovery in monosomic hybrid cell lines
    Lawrence C Shimmin
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
    DNA Seq 18:434-44. 2007
    ..We present the results of comprehensive variant discovery for the corticotropin releasing hormone gene (CRH on chromosome 8) encoding a neuropeptide that is central to many physiologic pathways...
  98. ncbi Glucocorticoid feedback increases the sensitivity of the limbic system to stress
    Christian J Cook
    Biomedical and Bioengineering Sector, Hort Research, Private Bag 3123, Hamilton, New Zealand
    Physiol Behav 75:455-64. 2002
    ..This alteration appears dependent on circulatory glucocorticoids...
  99. pmc How do the many etiologies of West syndrome lead to excitability and seizures? The corticotropin releasing hormone excess hypothesis
    K L Brunson
    Department of Pediatrics, University of California at Irvine, Irvine, CA 92697 4475, USA
    Brain Dev 23:533-8. 2001
    ..As part of this function, ACTH is known to suppress the production of corticotropin releasing hormone (CRH), a peptide that is produced in response to diverse insults and stressors...
  100. ncbi The corticotropin-releasing factor system as a potential target for antiobesity drugs
    Christian Doyon
    Département d anatomie et de physiologie, Universite Laval, Quebec, Canada
    Drug News Perspect 17:505-17. 2004
    ..Based on recent progress, we conclude that the CRF(2) receptor could be a potential target for the development of an antiobesity drug...
  101. pmc Divergent effects of corticotropin releasing hormone on endothelial cell nitric oxide synthase are associated with different expression of CRH type 1 and 2 receptors
    G Cantarella
    Department of Experimental Pharmacology, University of Catania School of Medicine, I-95125 Catania, Italy
    Br J Pharmacol 134:837-44. 2001
    ..NO-mediated effects of CRH on endothelial cells could be exploited in therapeutic strategies related to inflammatory and/or degenerative diseases...

Research Grants66

  1. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..The proposed research is hypothesis-driven, is based on strong preliminary evidence, is innovative with high likelihood for novel findings with applicability to humans. ..
  2. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ....
  3. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..Our study, using animal models of chronic psychological stress, proposes to fill this gap. ..
  4. Chronic stress-induced gene expression in colonic circular smooth muscle cells.
    Sushil K Sarna; Fiscal Year: 2012
    ..The primary mediators of the stress response are: corticotropin releasing hormone, norepinephrine, glucocorticoids and the neurotransmitters of the autonomic nervous system...
  5. Stress-induced hypertension and the role of the neuroimmune system
    PAUL MARVAR; Fiscal Year: 2012
    ..The combined expertise in the pathophysiology of hypertension, stress, translational neuroscience and neuroimmunology afford us a unique opportunity to pursue this research. ..
  6. GR-Mediated Epigenetic Regulation of the CRH Gene
    ROSALIE MARIE UHT; Fiscal Year: 2013
    ..abstract_text> ..
  7. DEVELOPMENT AND REGULATION OF EMOTION IN PRIMATES
    Ned H Kalin; Fiscal Year: 2013
    ..Elucidating the mechanisms that underlie the regulation of chronic anxiety in primates promises to provide crucial insights into the mechanisms underlying the pathophysiology of human anxiety and depressive disorders. ..
  8. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
    ....
  9. Identification and Validation of Human Hypothalamic Nuclei in-vivo and ex-vivo Us
    Nikolaos Makris; Fiscal Year: 2010
    ..PVN) is enlarged in patients with major depressive disorder (MDD), in PVN neurons that are dense in corticotropin releasing hormone (CRH) and estrogen receptor (ER)1...
  10. Amygdala CRH, Insomnia and Depression
    Rong Zhang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Stress exposure stimulates the release of corticotropin releasing hormone (CRH) in the brain and activates the hypothalamus-pituitary-adrenal (HPA) axis, which is key mechanism of stress regulation...
  11. Central actions of estrogens: Effects of GnRH neurons
    Suzanne M Moenter; Fiscal Year: 2013
    ..Integration of the data resulting from the study of an excitatory and an inhibitory afferet network into existing knowledge will increase our understanding of the central neuronal control of ovulation by estradiol. ..
  12. Melanocortin system stress and HPA axis
    Xin Yun Lu; Fiscal Year: 2010
    ....
  13. Determining the role of RFRP-3 in stress-related female infertility
    MOLLY JOANNE DICKENS; Fiscal Year: 2013
    ..capture microscopy and real-time RT-PCR to isolate and precisely analyze relative glucocorticoid and corticotropin releasing hormone receptors (GR and CRH-R1, respectively) on RFRP-3 neurons...
  14. Effects of early-life experience:role of CRH
    Tallie Z Baram; Fiscal Year: 2013
    ..the rat results in persistent alterations of stress-related genes: reduced expression of hypothalamic corticotropin releasing hormone (CRH) was found by the applicant already by the end of the enriched-experience period on postnatal ..
  15. In Vivo Brain Dialysis of Neuropeptides and Neuroimmune Signaling Proteins
    Julie A Stenken; Fiscal Year: 2012
    ..KC/GRO, IL-1b, IL-6, IL-10, and TNF-a} and neuropeptides {angiotensin IV, 2-amyloid, cholecystokinin, corticotropin releasing hormone, and neuropeptide Y)...
  16. Dysregulated Hypothalamic-pituitary-adrenal Axis During Biliary Hyperplasia
    Sharon Demorrow; Fiscal Year: 2013
    ..of glucocorticoid receptors, and (3) Reactivation of the HPA axis by central administration of corticotropin releasing hormone effectively inhibits the cholangiocyte outgrowth seen during cholestasis via the glucocorticoid ..
  17. Neural circuits underlying circadian regulation of behavior and physiology
    Nina Vujovic; Fiscal Year: 2012
    ..Circadian regulation of corticosteroid release may depend on an excitatory projection from the DMH to corticotropin releasing hormone-expressing neurons in the paraventricular hypothalamus (PVH)...
  18. CORTICOTROPIN RELEASING HORMONE SIGNALING AND NEWBORN NEURON CIRCUIT INTEGRATION
    Isabella Garcia; Fiscal Year: 2013
    ..This knowledge will allow us to work towards novel therapeutic approaches for cell and circuit-based brain repair. ..
  19. BARRIER FUNCTION OF THE GI TRACT IN HEALTH AND DISEASE
    W Allan Walker; Fiscal Year: 2013
    ..abstract_text> ..
  20. Oxytocin regulation of social buffering following stress
    ADAM STEVEN SMITH; Fiscal Year: 2012
    ..This research program represents several steps in examining the neurobiology mechanism underlying the social buffering effect in prairie voles. ..
  21. Neuroimmune Mechanisms of Glucocorticoid Resistance
    Andrew H Miller; Fiscal Year: 2010
    ..in turn is believed to contribute to excessive inflammation as well as hyperactivity of corticotropin releasing hormone (CRH) and sympathetic nervous system pathways, which may contribute to behavioral alterations...
  22. Phenotypic and Functional Determination of Central Extended Amygdala Cell Groups
    HEIDI E DAY; Fiscal Year: 2010
    ..Furthermore, this receptor is expressed on cells of the lateral CEA that contain corticotropin releasing hormone (CRH) and dynorphin, but is not expressed on cells that contain enkephalin, or on cells of the medial ..
  23. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..b>Corticotropin releasing hormone (CRH) is released from the hypothalamus under stress and activates the hypothalamic-pituitary-adrenal ..
  24. AMYGDALA GLUCOCORTICOID RECEPTOR FUNCTION IN STRESS
    LOUIS JOSEPH MUGLIA; Fiscal Year: 2013
    ..The results of our planned studies on the role of glucocorticoid receptor function in the amygdala hold promise for new insights into brain pathways regulating the responses to stress and the genesis and treatment of mental illness. ..
  25. Stress Effects on Alcohol Consumption: Age of onset and genes in heavy drinkers
    Gary S Wand; Fiscal Year: 2013
    ..Study findings will have scientific and clinical importance in establishing potential mechanisms for genetic and environmental influences on the relationship between stress and alcohol in heavy drinkers. ..
  26. Stress Hormones and Chondrogenic Vascular Calcification
    JODI FRANCES EVANS; Fiscal Year: 2010
    ..Lastly in Aim 3, the atherosclerosis-prone, ApoE-deficient mouse will be crossed with the corticotropin releasing hormone (CRH) deficient mouse...
  27. GABAergic and glucocorticoid regulation of CRH neurons and extinction of fear
    GEORGETTE MARIE GAFFORD; Fiscal Year: 2012
    ..GABA inhibits corticotropin releasing hormone (CRH), a well characterized neuropeptide engaged during stress...
  28. The Effect of Corticotropin Releasing Hormone on Cortical Arousal
    Royce Lee; Fiscal Year: 2010
    ..The probe combines intranasal CRH challenge with EEG measures of brain cortical activity. In order to understand the kinetics of the intranasal probe, an intravenous CRH challenge will also be performed, to provide comparison data. ..
  29. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
  30. Rehabilitation of Stress-Induced Insomnia
    Pingfu Feng; Fiscal Year: 2009
    ....
  31. Role of Extended Amygdala in Opiate and Cocaine Abuse
    GARY S ASTON-JONES; Fiscal Year: 2012
    ..norepinephrine innervation of the vBNST from the A2 neurons in the nucleus tractus solitarius, or corticotropin releasing hormone inputs from the amygdala or intrinsic BNST neurons, plays a role in potentiating activity of the ..
  32. CRH in stress-induced hippocampal neuroplasticity
    Tallie Z Baram; Fiscal Year: 2013
    ..we found that post hoc blocking of the receptor (CRFR1) of the stress-activated neuropeptide, corticotropin releasing hormone (CRH) immediately after the ES period, abrogated these deficits...
  33. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  34. CYTOKINE EFFECTS IN HYPOTHALAMUS/STEROID MODULATION
    Pushpa Kalra; Fiscal Year: 1999
    ....
  35. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    The skin is both target and source for proopiomelanocortin (POMC)-derived neuropeptides. Corticotropin releasing hormone (CRH) and CRH receptors (CRH-R) are also expressed and fully functional in rodent and human skin, but its ..
  36. TUMOR CELL SYNTHESIS AND SECRETION OF PEPTIDE HORMONES
    David Orth; Fiscal Year: 1991
    ..The results of these studies will provide new insights into the phenomenon of peptide hormone synthesis and secretion by tumor cells...
  37. Signal Processing in the Inner Retina
    Steven H DeVries; Fiscal Year: 2013
    ..in vision of a specific amacrine cell type that expresses cre recombinase under the control of the corticotropin releasing hormone (CRH) promoter...
  38. INTERLEUKIN REGULATION OF PROOPIOMELANOCORTIN GENE
    S Brown; Fiscal Year: 1990
    ..indicate that these immune response modifiers have activity in pituitary cells not unlike that of corticotropin releasing hormone (CRF)...
  39. SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEX
    Xueguo Zhang; Fiscal Year: 2002
    ..of NST neurons that is excited by the PVN will exhibit this response when the PVN is injected with corticotropin releasing hormone (CRH) and/or glucagon-like peptide-1 (GLP-1) and hypothesize that the excitatory influence of the PVN ..
  40. EPIDEMIOLOGY OF EXERTION, STRESS, AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2004
    ..buffers (social support, coping, religion), and physiologic markers of response to stress (plasma corticotropin releasing hormone (CRH), cortisol) will be evaluated througth the course of pregnancy...
  41. OPIOID AND ALCOHOL-REGULATED IMMUNE FUNCTION
    DIPAK SARKAR; Fiscal Year: 2001
    ..This along with his improved ability in mentoring student will greatly enhanced the candidate is professional growth and maturity as a researcher in the- alcohol field. ..
  42. REGULATION OF ANTERIOR PITUITARY FUNCTION BY POMC
    Sharon Wardlaw; Fiscal Year: 1990
    ..regulation of proopiomelanocortin (POMC) synthesis, release and processing in brain by sex steroids, corticotropin releasing hormone (CRH), and prolactin...
  43. CANNABINOIDS AND THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    Laura Murphy; Fiscal Year: 2002
    ..abstract_text> ..
  44. OPIOID REGULATION OF POMC IN THE HYPOTHALAMUS
    Sharon Wardlaw; Fiscal Year: 2000
    ..endogenous opioid precursor proopiomelanocortin (POMC) in the hypothalamus and its interactions with corticotropin releasing hormone (CRH) which plays a critical role in coordinating the neuroendocrine response to stress...
  45. Molecular Genetics of the HPA(I) Axis
    Phillip Danielson; Fiscal Year: 2002
    ..ACTH is well established as a critical link in this network. Neurons in the hypothalamus secrete corticotropin releasing hormone (CRH), which induces the secretion of ACTH from the anterior pituitary...
  46. HPA Axis Activation and Nicotine Use
    Theodore Friedman; Fiscal Year: 2005
    ..The use of glucocorticoid synthesis inhibitors or antagonists, antalarmin, or other CRH and/or AVP antagonists, may be helpful in smoking cessation programs in humans. ..
  47. ENDOCRINE REGULATION OF CORTICOTROPIN RELEASING HORMONE
    GAIL ADLER; Fiscal Year: 1992
    Human corticotropin releasing hormone (hCRH), a 41 amino acid peptide synthesized in the hypothalamus, is a major regulator of the hypothalamic-pituitary-adrenal axis and thus plays a critical role in the normal endocrine response to ..
  48. Early Predictors of Postpartum Depression
    ILONA YIM; Fiscal Year: 2009
    ..Specifically, corticotropin releasing hormone (CRH) is released into the maternal and fetal blood stream by the placenta, resulting in exponential ..
  49. MECHANISM OF DEPRESSIVE BEHAVIOR IN WISTAR-KYOTO RATS
    Shanaz Tejani Butt; Fiscal Year: 2001
    ..studies report that WKY rats have high levels of stress-induced adrenocorticotropin and low levels of corticotropin releasing hormone, suggesting a defective feedback in the hypothalamic-pituitary-adrenal (HPA) axis...
  50. DIET EFFECT ON ENERGY METABOLISM
    DALE ROMSOS; Fiscal Year: 1999
    ..in ob/ob mice leads to altered regulation in the central nervous system of the neuropeptide Y and corticotropin releasing hormone systems, and that these alterations also depend on the presence of glucocorticoids or selected ..
  51. Neural and Behavioral Impact of T Cell Activation
    Alexander Kusnecov; Fiscal Year: 2009
    ..This has been associated with increased transcription of central corticotropin releasing hormone (CRH) and the reputed "anti-stress" peptide, nociceptin/orphanin FQ (N/OFQ) in the amygdala, and ..
  52. Glucocorticoid Resistance in Immune-Based Depression
    Charles Raison; Fiscal Year: 2006
    ....
  53. Cytokine-CRH Interactions in IFN-alfa-Induced Depression
    Charles Raison; Fiscal Year: 2009
    ..abstract_text> ..
  54. Cellular Plasticity and HPA Axis Dysfunction
    Jeffrey Tasker; Fiscal Year: 2009
    ..to and a reduced sensitivity to glucocorticoids of the cells that trigger HPA axis activation, the corticotropin releasing hormone (CRH) neurons of the paraventricular nucleus (PVN)...
  55. HORMONE RHYTHMS: METABOLIC SIGNIFICANCE IN DEPRESSION
    Robert Rubin; Fiscal Year: 2005
    ..moderately hyperactive in 30-50 percent of depressed patients, most likely on the basis of increased corticotropin releasing hormone (CRH) and arginine vasopressin (AVP) secretion from the hypothalamus...
  56. Sleep Studies in HIV+ Older Children/Adolescents
    William Shearer; Fiscal Year: 2007
    ....
  57. NEUROENDOCRINE AND BEHAVIORAL ACTIONS OF CORTICOTROPIN R
    Joseph Majzoub; Fiscal Year: 2003
    ..What is the role of CRH and related molecules in the suppression of appetite and reproduction during the stress response? ..
  58. Integration of Stress and Reproductive Axes by Dopamine
    Simon Evans; Fiscal Year: 2007
    ..However, these neurons are believed to project to corticotropin releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVN) and are thus in a position to ..
  59. Activation of CRH Neurons by the Neuropeptide PACAP
    Gabor Legradi; Fiscal Year: 2005
    ..of the neuroendocrine, autonomic and behavioral responses to stress are integrated by parvocellular corticotropin releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN)...
  60. HUMORAL REGULATION OF WAKING--THE ROLE OF CRH
    Mark Opp; Fiscal Year: 1999
    ....
  61. CRH Receptors and Stress Response Pathways
    Mary Stenzel Poore; Fiscal Year: 2007
    ..Our long-term objective is to elucidate the role of CRH pathways in governing the recovery phase of the response to stress [unreadable] [unreadable]..
  62. NEUROENDOCRINE REGULATION OF THE STRESS RESPONSE
    JAMES KOENIG; Fiscal Year: 2000
    ..These studies aim to reveal important new information about the regulation of stress hormone secretion by glutamate and may be significant in better understanding brain mechanisms in neuropsychiatric and other stress-related disorders. ..
  63. CENTRAL REGULATION OF FERTILITY
    REID NORMAN; Fiscal Year: 2000
    ..These studies will examine the role of VP in the inhibition of the pituitary-gonadal axis in response to both psychological and metabolic stimuli. ..
  64. MOLECULAR MECHANISM OF CRH EXPRESSION
    TALLIE BARAM; Fiscal Year: 1992
    ..We will use the maximal electroshock seizure model and chemically induced seizures to study whether the CRH neuronal system and its manipulation, or exogenous CRH administration alter the suspectibility of the immature brain to seizures...
  65. IFN ALPHA-INDUCED DEPRESSION
    Andrew Miller; Fiscal Year: 2003
    ..that IFNa, induces factors known to contribute to the expression of depressive symptoms including corticotropin releasing hormone (CRH) and the proinflammatory cytokines, tumor necrosis factor a (TNFa) and IL-10...
  66. CRH AND INFLAMMATION IN CEREBRAL ISCHEMIC INJURY
    Mary Stenzel Poore; Fiscal Year: 2002
    ..Specific Aim 2. To characterize the effect of CRH on purified non-neuronal cells from the CNS in culture. Specific Aim 3. To test the role of CRH in the inflammatory response following ischemia in vivo. ..