calcitonin

Summary

Summary: A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.

Top Publications

  1. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
  2. ncbi Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    JAMA 302:1059-66. 2009
  3. ncbi Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis
    Bernard Uzzan
    APHP Laboratoire de Pharmacologie Hormonologie, Hopital Avicenne, Bobigny, France
    Crit Care Med 34:1996-2003. 2006
  4. ncbi Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis
    Benjamin M P Tang
    Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia
    Lancet Infect Dis 7:210-7. 2007
  5. pmc Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard School of Public Health, Boston, MA 02115, USA
    Clin Infect Dis 55:651-62. 2012
  6. ncbi Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis
    Ville Pettila
    Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 28:1220-5. 2002
  7. ncbi Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations
    Kenneth L Becker
    Veterans Affairs Medical Center, Washington, DC, USA
    Crit Care Med 36:941-52. 2008
  8. ncbi Understanding diagnostic tests 3: Receiver operating characteristic curves
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Manchester, UK
    Acta Paediatr 96:644-7. 2007
  9. ncbi The role of procalcitonin in febrile neutropenic patients: review of the literature
    Y Sakr
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University, Erlanger Allee 103, Jena, Germany
    Infection 36:396-407. 2008
  10. pmc Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target
    Kenneth L Becker
    George Washington University and Veterans Affairs Medical Center, Washington, DC 20422, USA
    Br J Pharmacol 159:253-64. 2010

Detail Information

Publications325 found, 100 shown here

  1. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
    b>Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles...
  2. ncbi Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial
    Philipp Schuetz
    Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland
    JAMA 302:1059-66. 2009
    ..In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in patients with lower respiratory tract infections (LRTIs)...
  3. ncbi Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis
    Bernard Uzzan
    APHP Laboratoire de Pharmacologie Hormonologie, Hopital Avicenne, Bobigny, France
    Crit Care Med 34:1996-2003. 2006
    ..To draw and compare the summary receiver operating characteristics curves for procalcitonin and C-reactive protein from the literature...
  4. ncbi Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis
    Benjamin M P Tang
    Department of Intensive Care Medicine, Nepean Hospital, Penrith, New South Wales, Australia
    Lancet Infect Dis 7:210-7. 2007
    ..The findings from this study do not lend support to the widespread use of the procalcitonin test in critical care settings...
  5. pmc Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard School of Public Health, Boston, MA 02115, USA
    Clin Infect Dis 55:651-62. 2012
    ..We undertook an individual patient data meta-analysis to assess safety of this approach in different ARI diagnoses and different clinical settings...
  6. ncbi Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis
    Ville Pettila
    Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 28:1220-5. 2002
    ....
  7. ncbi Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations
    Kenneth L Becker
    Veterans Affairs Medical Center, Washington, DC, USA
    Crit Care Med 36:941-52. 2008
    ..In particular, the need for a more sensitive assay will be emphasized. For these purposes, the medical literature comprising clinical studies pertaining to the measurement of serum ProCT in various clinical settings was examined...
  8. ncbi Understanding diagnostic tests 3: Receiver operating characteristic curves
    Anthony K Akobeng
    Department of Paediatric Gastroenterology, Central Manchester and Manchester Children s University Hospitals, Booth Hall Children s Hospital, Manchester, UK
    Acta Paediatr 96:644-7. 2007
    ..In this paper, the author explains how the ROC curve can be used to select optimal cut-off points for a test result, to assess the diagnostic accuracy of a test, and to compare the usefulness of tests...
  9. ncbi The role of procalcitonin in febrile neutropenic patients: review of the literature
    Y Sakr
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University, Erlanger Allee 103, Jena, Germany
    Infection 36:396-407. 2008
    ....
  10. pmc Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target
    Kenneth L Becker
    George Washington University and Veterans Affairs Medical Center, Washington, DC 20422, USA
    Br J Pharmacol 159:253-64. 2010
    ..In this condition, the secretion of procalcitonin (ProCT), the prohormone of calcitonin, is augmented greatly, attaining levels up to thousands of fold of normal...
  11. ncbi Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
    Jaesook Roh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    J Biol Chem 279:7264-74. 2004
    b>Calcitonin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique group of peptide hormones important for homeostasis in diverse tissues...
  12. ncbi Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial
    Jens U Jensen
    Copenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark
    Crit Care Med 39:2048-58. 2011
    ..The objective of this trial was to determine whether a strategy of antimicrobial spectrum escalation, guided by daily measurements of the biomarker procalcitonin, could reduce the time to appropriate therapy, thus improving survival...
  13. ncbi Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    Lotte Bjerre Knudsen
    Department of Biology and Pharmacology Mgt, Novo Nordisk A S, Novo Nordisk Park, Maaloev DK 2760, Denmark
    Endocrinology 151:1473-86. 2010
    ..The GLP-1 receptor was localized to rodent C-cells. GLP-1 receptor agonists stimulated calcitonin release, up-regulation of calcitonin gene expression, and subsequently C-cell hyperplasia in rats and, to a ..
  14. ncbi Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules
    Giuseppe Costante
    Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia, Italy
    J Clin Endocrinol Metab 92:450-5. 2007
    Routine serum calcitonin (CT) measurement in patients with thyroid nodules for diagnosis of medullary thyroid carcinoma (MTC) is controversial.
  15. ncbi The plasma elimination rate and urinary secretion of procalcitonin in patients with normal and impaired renal function
    M Meisner
    Department of Anaesthesiology and Intensive Care Therapy, University of Jena, Bachstr. 18, D-07743 Jena, Germany
    Eur J Anaesthesiol 18:79-87. 2001
    ..We conclude that procalcitonin can be used diagnostically in patients with renal failure as well as in those with normal renal function...
  16. ncbi Serum levels of C-reactive protein and procalcitonin in critically ill patients with cirrhosis of the liver
    Daliana Peres Bota
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    J Lab Clin Med 146:347-51. 2005
    ..Moreover, the predictive power of CRP and PCT for infection was similar for patients with and without cirrhosis...
  17. pmc NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG
    Rui Huang
    Biophysics and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 1055, USA
    J Mol Biol 416:108-20. 2012
    b>Calcitonin is a 32-residue peptide hormone known for its hypocalcemic effect and its inhibition of bone resorption...
  18. ncbi C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia
    G Hillas
    Dept of Respiratory and Critical Care Medicine, SOTIRIA Chest Diseases Hospital, Athens, Greece
    Eur Respir J 35:805-11. 2010
    ..The only factor predicting the development of septic shock was SOFA on D1 (OR 7.44, 95% CI 1.330-5.715). Neither PCT and CRP threshold values nor their kinetics can predict VAP survival or septic shock development...
  19. pmc Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?
    James Barwell
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Br J Pharmacol 166:51-65. 2012
    The calcitonin receptor (CTR) and calcitonin receptor-like receptor (CLR) are two of the 15 human family B (or Secretin-like) GPCRs...
  20. ncbi Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity
    L Zhang
    Department of Anatomy and Neurosciences, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Pain 89:265-73. 2001
    ..to involve a variety of transmitters released from nerve terminals, including amino acids, substance P (SP) and calcitonin gene-related peptide (CGRP)...
  21. ncbi Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators
    M Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Respir J 30:556-73. 2007
    ..The concept is based on a ubiquitous expression of calcitonin peptides during sepsis...
  22. ncbi 18F-DOPA positron emission tomography for tumour detection in patients with medullary thyroid carcinoma and elevated calcitonin levels
    S Hoegerle
    Department of Radiology, Albert-Ludwigs University Freiburg, Germany
    Eur J Nucl Med 28:64-71. 2001
    ..diagnostic imaging of tumour manifestations in patients with medullary thyroid carcinoma and elevated calcitonin levels is often difficult...
  23. ncbi Prognostic factors of disease-free survival after thyroidectomy in 170 young patients with a RET germline mutation: a multicenter study of the Groupe Francais d'Etude des Tumeurs Endocrines
    V Rohmer
    Centre Hospitalier Universitaire Angers, Endocrinologie, Faculte de Medecine, Université Angers, Angers 49933, France
    J Clin Endocrinol Metab 96:E509-18. 2011
    ..In hereditary medullary thyroid carcinoma (HMTC), prophylactic surgery is the only curative option, which should be properly defined both in time and extent...
  24. ncbi Back to the future: revisiting parathyroid hormone and calcitonin control of bone remodeling
    F J A de Paula
    Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME 04074 7205, USA
    Horm Metab Res 42:299-306. 2010
    ..b>Calcitonin (CT) and parathormone (PTH) are complementary hormones involved in the acquisition and maintenance of bone mass ..
  25. ncbi Utility of procalcitonin concentration in the evaluation of patients with malignant diseases and elevated C-reactive protein plasma concentrations
    Silke Schuttrumpf
    Department of Hematology Oncology, University of Gottingen, Gottingen, Germany
    Clin Infect Dis 43:468-73. 2006
    ..Elevated plasma concentrations of the C-reactive protein (CRP) are frequently found in patients with malignant diseases. Discrimination between infection and noninfectious acute-phase reactions is essential for therapeutic decisions...
  26. pmc Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction
    Gian Paolo Castelli
    Intensive Care, Anesthesiology and Pain Relief Unit, C Poma Hospital, Mantova, Italy
    Crit Care 8:R234-42. 2004
    ..We hypothesised that PCT and CRP concentrations are different in patients with infection or with no infection at a similar severity of organ dysfunction or of systemic inflammatory response...
  27. ncbi Procalcitonin for guidance of antibiotic therapy
    Philipp Schuetz
    Harvard School of Public Health, MA, USA
    Expert Rev Anti Infect Ther 8:575-87. 2010
    ..This review aims to provide physicians with an overview of the strengths and limitations of procalcitonin guidance for antibiotic therapy when used in different clinical settings and in patients with different underlying infections...
  28. ncbi Progression of medullary thyroid carcinoma: assessment with calcitonin and carcinoembryonic antigen doubling times
    Anne Laure Giraudet
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy and University Paris Sud, 94805 Villejuif Cedex, France
    Eur J Endocrinol 158:239-46. 2008
    The progression of medullary thyroid cancer is difficult to assess with imaging modalities; we studied the interest of calcitonin and carcinoembryonic antigen (CEA) doubling times and of Ki-67 labeling and mitotic index (MI).
  29. ncbi Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro
    M W Nijsten
    Department of Surgery, University Hospital Groningen, and the Groningen Institute for Drug Studies, The Netherlands
    Crit Care Med 28:458-61. 2000
    ..The source of production and its mechanism of induction are unknown. We investigated the inducibility of PCT both in vivo and in vitro and compared the behavior of PCT with those of SAA and CRP...
  30. ncbi Effect of procalcitonin-guided treatment in patients with infections: a systematic review and meta-analysis
    H Tang
    Intensive Care Unit, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, People s Republic of China
    Infection 37:497-507. 2009
    ....
  31. ncbi In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue
    Philippe Linscheid
    Department of Research, University Hospitals, Hebelstrasse 20, 4031 Basel, Switzerland
    Endocrinology 144:5578-84. 2003
    Circulating levels of calcitonin precursors (CTpr), including procalcitonin (ProCT), increase up to several thousand-fold in human sepsis, and immunoneutralization improves survival in two animal models of this disease...
  32. ncbi Comparison of procalcitonin and C-reactive protein as markers of sepsis
    Aldo Luzzani
    Institute of Anesthesiology and Intensive Care, University Hospital, Verona, Italy
    Crit Care Med 31:1737-41. 2003
    ..To compare the clinical informative value of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in the detection of infection and sepsis and in the assessment of severity of sepsis...
  33. ncbi Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials
    Petros Kopterides
    Second Critical Care Department, Attiko University Hospital, University of Athens Medical School, Athens, Greece
    Crit Care Med 38:2229-41. 2010
    ..We sought to determine the effectiveness and safety of procalcitonin-guided algorithms in the management of septic patients in the intensive care unit...
  34. pmc Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future
    Philipp Schuetz
    Harvard School of Public Health, 667 Huntington Ave, 02115 Boston MA, USA
    BMC Med 9:107. 2011
    ..The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and discuss the reliability of this marker when used with validated diagnostic algorithms...
  35. ncbi GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide
    Laszlo Hegedus
    Department of Endocrinology, Odense University Hospital, Odense, Denmark
    J Clin Endocrinol Metab 96:853-60. 2011
    Serum calcitonin (CT) is a well-accepted marker of C-cell proliferation, particularly in medullary thyroid carcinoma...
  36. ncbi Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 171:1322-31. 2011
    ..We propose specific procalcitonin algorithms for low-, moderate-, and high-acuity patients as a basis for future trials aiming at reducing antibiotic overconsumption...
  37. ncbi Procalcitonin as an early marker of infection in neonates and children
    A M C van Rossum
    Medical Centre Rijnmond Zuid, Rotterdam, Netherlands
    Lancet Infect Dis 4:620-30. 2004
    ..Procalcitonin is therefore a useful additional tool for the diagnosis of bacterial disease in neonates and children...
  38. ncbi Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes
    B C Sondergaard
    Nordic Bioscience Diagnostics, Herlev, Denmark
    Osteoarthritis Cartilage 14:759-68. 2006
    b>Calcitonin was recently reported to counter progression of cartilage degradation in an experimental model of osteoarthritis, and the effects were primarily suggested to be mediated by inhibition of subchondral bone resorption...
  39. ncbi Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care
    Matthias Briel
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Arch Intern Med 168:2000-7; discussion 2007-8. 2008
    ..We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without increasing the restrictions experienced by patients by more than 1 day...
  40. pmc Agonist-dependent consequences of proline to alanine substitution in the transmembrane helices of the calcitonin receptor
    R J Bailey
    Proteomics and Biomedicine Research Group, School of Biological Sciences, University of Auckland, Auckland, New Zealand
    Br J Pharmacol 151:678-87. 2007
    ..These residues are little studied in family B GPCRs but experiments with the VPAC1 receptor and calcitonin receptor-like receptor (CL) show parallels with family A receptors...
  41. ncbi Soluble urokinase-type plasminogen activator receptor in patients with suspected infection in the emergency room: a prospective cohort study
    R Uusitalo-Seppälä
    Department of Infectious Diseases, Satakunta Central Hospital, Pori, Finland
    J Intern Med 272:247-56. 2012
    ..The soluble form of urokinase-type plasminogen activator (suPAR) was evaluated as an early prognostic marker of sepsis in patients with suspected infection...
  42. ncbi An ESICM systematic review and meta-analysis of procalcitonin-guided antibiotic therapy algorithms in adult critically ill patients
    Dimitrios K Matthaiou
    Department of Internal Medicine, G Gennimatas General Hospital, 41 Ethnikis Amynis Str, 546 35 Thessaloniki, Greece
    Intensive Care Med 38:940-9. 2012
    ..We sought to perform a systematic review and meta-analysis of procalcitonin(PCT)-guided antibiotic therapy algorithms for critically ill adult patients...
  43. ncbi Procalcitonin's role in the sepsis cascade. Is procalcitonin a sepsis marker or mediator?
    A A Dahaba
    Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria
    Minerva Anestesiol 75:447-52. 2009
    ..This ominous sign clearly demonstrates that patients with poor prognosis would manifest, at a certain stage, a decrease in their ability to mount an effective response to sepsis...
  44. ncbi Sporadic hypercalcitoninemia: clinical and therapeutic consequences
    C Scheuba
    Department of Surgery, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Endocr Relat Cancer 16:243-53. 2009
    b>Calcitonin screening' is not accepted as the standard of care in daily practice...
  45. ncbi Clinical significance of serum procalcitonin levels in patients with acute or chronic liver disease
    Ioannis S Elefsiniotis
    Department of Internal Medicine, Hippokration Hospital of Athens, Carchidonos 9, A Glyfada, GR 16562 Greece
    Eur J Gastroenterol Hepatol 18:525-30. 2006
    ....
  46. ncbi Detection of procalcitonin (PCT) in healthy controls and patients with local infection by a sensitive ILMA
    Nils G Morgenthaler
    Research Department, B R A H M S AG, Biotechnology Centre Hennigsdorf Berlin, Germany
    Clin Lab 48:263-70. 2002
    ..The aim of our study was the characterization of a new sensitive PCT assay, the establishment of reference values and the assessment of diagnostic accuracy...
  47. pmc Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia
    David T Huang
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Emerg Med 52:48-58.e2. 2008
    ..Our objective is to describe the pattern of procalcitonin in community-acquired pneumonia and determine whether procalcitonin provides prognostic information beyond the Pneumonia Severity Index and CURB-65...
  48. ncbi Plasma procalcitonin and the risk of cardiovascular events and death: a prospective population-based study
    A Schiopu
    Department of Clinical Sciences, Lund University, Skåne University Hospital Malmö, Malmo, Sweden
    J Intern Med 272:484-91. 2012
    ..We evaluated the ability of PCT to predict future cardiovascular events in a population of apparently healthy individuals...
  49. ncbi Biomarkers in the critically ill patient: procalcitonin
    Konrad Reinhart
    Clinic of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University Jena, Erlanger Allee 101, 07740 Jena, Germany
    Crit Care Clin 27:253-63. 2011
    ..In this review the present use of PCT on the ICU and in critically ill patients is summarized, included it's role for diagnosis of severe sepsis and septic shock and antibiotic stewardship with PCT...
  50. ncbi Procalcitonin is not an accurate marker of spontaneous bacterial peritonitis in patients with cirrhosis
    L Spahr
    Division of Gastroenterology and Hepatology, University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Hepatogastroenterology 48:502-5. 2001
    ..The clinical features of peritonitis are usually absent in cirrhotic patients with an ascitic fluid infection, raising the interest for specific biological markers of inflammation...
  51. ncbi Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes
    Philippe Linscheid
    Department of Research, Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital, Basel, Switzerland
    Crit Care Med 32:1715-21. 2004
    To explore the roles of peripheral blood mononuclear cells (PBMCs) and PBMC-derived macrophages in sepsis-related increased procalcitonin and calcitonin gene-related peptide (CGRP) I production.
  52. ncbi Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin
    Abdallah Makhlof
    Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Int J Pharm 397:92-5. 2010
    ..23-0.33 microm with positive surface charge and high calcitonin entrapment...
  53. ncbi An analysis of C-reactive protein, procalcitonin, and D-dimer in pre-eclamptic patients
    Umran Kucukgoz Gulec
    Department of Obstetrics and Gynecology, Cukurova University, Adana, Turkey
    Am J Reprod Immunol 68:331-7. 2012
    ..The aim of this study was to evaluate serum procalcitonin (PCT), C-reactive protein (CRP), and plasma D-Dimer levels in mild and severe pre-eclampsia...
  54. ncbi Potency and tolerance of calcitonin stimulation with high-dose calcium versus pentagastrin in normal adults
    Patricia Doyle
    Department of Nuclear Medicine, University of Wurzburg, Josef Schneider Strasse 2, Wurzburg, Germany
    J Clin Endocrinol Metab 94:2970-4. 2009
    The objectives of the study was to compare pentagastrin- and calcium-stimulated serum human calcitonin (hCT) levels for nonsmoking healthy adults without evidence of thyroid disorders and determine reference ranges of basal and ..
  55. ncbi Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis
    B Muller
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:396-404. 2001
    b>Calcitonin precursors (CTpr), including procalcitonin, are important markers and also potentially harmful mediators in response to microbial infections. The source and function of CTpr production in sepsis, however, remains an enigma...
  56. ncbi An assessment of parathyroid hormone, calcitonin, 1,25 (OH)2 vitamin D3, estradiol and testosterone in men with active calcium stone disease and evaluation of its biochemical risk factors
    Nasser Shakhssalim
    Shahid Labbafinejad Medical Center, Shahid Beheshti University, M C, No 103, Boostan 9th St, Pasdaran Ave, P O Box 1666677951, Tehran, IR Iran
    Urol Res 39:1-7. 2011
    The aim of this study is to investigate the serum levels of parathyroid hormone (PTH), calcitonin, 1,25 (OH)(2) vitamin D3, estradiol and testosterone in male patients with active renal calcium stone disease compared with controls and ..
  57. ncbi Serum and ascitic procalcitonin levels in cirrhotic patients with spontaneous bacterial peritonitis: diagnostic value and relationship to pro-inflammatory cytokines
    A Viallon
    Emergency and Intensive Care Units, Bellevue Hospital, Saint Etienne, France
    Intensive Care Med 26:1082-8. 2000
    ..To assess the potential role of procalcitonin and pro-inflammatory cytokines, TNF-alpha, and IL-6, in the diagnosis of spontaneous bacterial peritonitis (SBP)...
  58. ncbi Procalcitonin as a prognostic and diagnostic tool for septic complications after major trauma
    Gian Paolo Castelli
    Department of Anaesthesiology, Intensive Care Therapy and Pain Relief, Mantova, Italy
    Crit Care Med 37:1845-9. 2009
    ..A secondary aim was to determine whether there was a prognostic value of PCT for severity of injury, organ dysfunction, and sepsis...
  59. ncbi Procalcitonin, soluble interleukin-2 receptor, and soluble E-selectin in predicting the severity of acute pancreatitis
    M L Kylänpää-Bäck
    Department of Surgery, Helsinki University Central Hospital, Finland
    Crit Care Med 29:63-9. 2001
    ..To investigate whether marker(s) of systemic inflammation detect, at an early stage of acute pancreatitis, patients who may ultimately develop severe disease...
  60. ncbi Procalcitonin strip test in the early detection of severe acute pancreatitis
    M L Kylänpää-Bäck
    Department of Surgery, Helsinki University Central Hospital, Finland
    Br J Surg 88:222-7. 2001
    ....
  61. ncbi Improved intestinal delivery of salmon calcitonin by Lys18-amine specific PEGylation: stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy
    Yu Seok Youn
    Drug Targeting Laboratory, College of Pharmacy, Sungkyunkwan University, 300, Chonchon dong, Jangan ku, Suwon City 440 746, South Korea
    J Control Release 114:334-42. 2006
    Peptides like salmon calcitonin (sCT) are subjected to aggressive proteolytic attack by various intestinal enzymes, and fractions that enter the systemic circulation via the intestinal route are rapidly inactivated by tissue accumulation ..
  62. pmc Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes
    Bodil Cecilie Sondergaard
    Nordic Bioscience A S, Herlev Hovedgade 207, 2730 Herlev, Denmark
    BMC Musculoskelet Disord 11:62. 2010
    b>Calcitonin has been demonstrated to have chondroprotective effects under pre-clinical settings. It is debated whether this effect is mediated through subchondral-bone, directly on cartilage or both in combination...
  63. pmc Clinical review: Incidentally discovered medullary thyroid cancer: diagnostic strategies and treatment
    Shabina R Ahmed
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 96:1237-45. 2011
    ..Barriers to accurate preoperative diagnosis and management strategies after the discovery of occult MTC are reviewed...
  64. ncbi Serum procalcitonin at the time of admission to the ICU as a predictor of short-term mortality
    Fan Su Meng
    ICU, General Hospital of Guangzhou Military Command, 111 Liu Hua Road, Yue Xiu District, Guangzhou, China
    Clin Biochem 42:1025-31. 2009
    ..This purpose of this study was to determine if serum procalcitonin (PCT) concentration at the time of admission to the ICU is a predictor of all-cause short-term mortality...
  65. pmc Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults
    Michael Adamzik
    Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen und Universität Duisburg Essen, Hufelandstr, 55, 45130 Essen, Germany
    Crit Care 14:R178. 2010
    ..We investigated whether thromboelastometry variables are suitable as biomarkers for severe sepsis in critically ill adults...
  66. ncbi The timing of total thyroidectomy in RET gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years experience at one single center
    Rossella Elisei
    Department of Endocrinology and Metabolism, World Health Organization Collaborating Center for the Diagnosis and Treatment of Thyroid Cancer and Other Thyroid Diseases, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 97:426-35. 2012
    Medullary thyroid carcinoma (MTC) is a calcitonin (CT)-producing C-cell tumor. In hereditary cases, a germline RET mutation is found in 98% of families...
  67. ncbi Procalcitonin to guide duration of antimicrobial therapy in intensive care units: a systematic review
    Rajender Agarwal
    Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
    Clin Infect Dis 53:379-87. 2011
    ..Procalcitonin guidance of antimicrobial duration appears to decrease antimicrobial use in the ICU safely and significantly and may also decrease the length of stay in the ICU...
  68. ncbi Effectiveness and safety of procalcitonin-guided antibiotic therapy in lower respiratory tract infections in "real life": an international, multicenter poststudy survey (ProREAL)
    Werner C Albrich
    Medical University Department, Kantonsspital Aarau, Aarau, Switzerland
    Arch Intern Med 172:715-22. 2012
    ..In controlled studies, procalcitonin (PCT) has safely and effectively reduced antibiotic drug use for lower respiratory tract infections (LRTIs). However, controlled trial data may not reflect real life...
  69. ncbi Early detection of an early onset infection in the neonate based on measurements of procalcitonin and C-reactive protein concentrations in cord blood
    Agnieszka Kordek
    Pomeranian Medical University, Szczecin, Poland
    Clin Chem Lab Med 46:1143-8. 2008
    ....
  70. ncbi Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
    Philipp Schuetz
    Department of Emergency Medicine, Harvard School of Public Health, Boston, MA, USA
    Cochrane Database Syst Rev 9:CD007498. 2012
    ..In recent years, procalcitonin - the prohormone of calcitonin - has emerged as a promising marker for the diagnosis of bacterial infections and for improving decisions about ..
  71. ncbi Serum procalcitonin and other biologic markers to distinguish between bacterial and aseptic meningitis
    Francois Dubos
    Clinical Epidemiology Unit, Department of Pediatrics, Saint Vincent de Paul Hospital, AP HP, Paris Descartes University, and INSERM U149, Paris, France
    J Pediatr 149:72-6. 2006
    ..To identify the biologic tests that best distinguish between bacterial and aseptic meningitis in an emergency department (ED)...
  72. pmc Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD
    Mona Bafadhel
    Institute for Lung Health, University of Leicester, Leicester, England
    Chest 139:1410-8. 2011
    ..We aimed to compare the usefulness of the biomarkers procalcitonin and C-reactive protein (CRP) in patients with pneumonia or exacerbations of asthma or COPD...
  73. ncbi A comparison of teriparatide and calcitonin therapy in postmenopausal Asian women with osteoporosis: a 6-month study
    A W C Kung
    Dept of Medicine, University of Hong Kong, Queen Mary Hospital, China
    Curr Med Res Opin 22:929-37. 2006
    ..BMD) may be used as a measure of fracture risk, we sought to compare the effects of teriparatide with salmon calcitonin treatment on changes in BMD, biochemical bone markers, and safety in postmenopausal Asian women with osteoporosis...
  74. pmc Calcitonin forms oligomeric pore-like structures in lipid membranes
    Marco Diociaiuti
    Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanita, 299 00161 Rome, Italy
    Biophys J 91:2275-81. 2006
    b>Calcitonin is a polypeptidic hormone involved in calcium metabolism in the bone...
  75. ncbi Serum procalcitonin, C-reactive protein and white blood cell levels following hypothermia after cardiac arrest: a retrospective cohort study
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Eur J Clin Invest 40:376-81. 2010
    ..The aim of this study was to investigate time course of procalcitonin (PCT), C-reactive protein (CRP) and white blood cell (WBC) levels in patients with therapeutic hypothermia after cardiac arrest...
  76. ncbi Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: experience from a multicentre study
    H Giamarellou
    4th Department of Internal Medicine, Athens Medical School, Athens, Greece
    Clin Microbiol Infect 10:628-33. 2004
    ..0 ng/mL. Estimated concentrations of < 0.5 ng/mL indicate that infection is unlikely, but it was observed that bacteraemia associated with coagulase-negative staphylococci may fail to elevate serum procalcitonin levels...
  77. ncbi Differential diagnostic value of procalcitonin in surgical and medical patients with septic shock
    Christophe Clec'h
    Medico Surgical Intensive Care Unit, Avicenne Teaching Hospital, Bobigny, France
    Crit Care Med 34:102-7. 2006
    ..To assess whether different diagnostic and prognostic cutoff values of procalcitonin should be considered in surgical and in medical patients with septic shock...
  78. ncbi Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study
    S Schroeder
    Interdisciplinary Intensive Care Unit, Department of Anaesthesiology and Intensive Care Medicine, Westküstenklinikum, Heide, Germany
    Langenbecks Arch Surg 394:221-6. 2009
    ..In the present study, we aimed to investigate the clinical usefulness of PCT for guiding antibiotic treatment in surgical intensive care patients with severe sepsis...
  79. ncbi Oral salmon calcitonin--pharmacology in osteoporosis
    Kim Henriksen
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Expert Opin Biol Ther 10:1617-29. 2010
    ..This highlights the need for safe intervention possibilities, which have sustained beneficial effects post-treatment...
  80. ncbi Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis
    Sebastien Gibot
    Service de Reanimation Medicale, Hopital Central, Nancy, France
    Crit Care Med 33:792-6. 2005
    ..To describe the course of plasma sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin (PCT), and C-reactive protein (CRP) concentrations during sepsis and their clinical informative value in predicting outcome...
  81. pmc Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections
    Kristian Kofoed
    Clinical Research Unit, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Crit Care 11:R38. 2007
    ..Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. We therefore compared the diagnostic characteristics of novel and routinely used biomarkers of sepsis alone and in combination...
  82. ncbi Procalcitonin and C-reactive protein as diagnostic markers of severe bacterial infections in febrile infants and children in the emergency department
    Barbara Andreola
    Department of Pediatrics, University of Padova, Italy
    Pediatr Infect Dis J 26:672-7. 2007
    ....
  83. ncbi Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD
    Daiana Stolz
    Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Chest 131:1058-67. 2007
    ....
  84. ncbi Diagnostic accuracy of 18F-FDG PET in restaging patients with medullary thyroid carcinoma and elevated calcitonin levels
    Seng C Ong
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 48:501-7. 2007
    Medullary thyroid carcinoma (MTC) is a rare endocrine tumor arising from the C-cells of the thyroid gland. Calcitonin is the principal serum tumor marker...
  85. pmc The influence of corticosteroids on the release of novel biomarkers in human endotoxemia
    Martijn D de Kruif
    Center for Experimental and Molecular Medicine, Room G2 132, Academic Medical Center, Meibergdreef 9, 1105 Amsterdam, AZ, The Netherlands
    Intensive Care Med 34:518-22. 2008
    ..However, it is not known whether these biomarkers are influenced by sepsis intervention strategies. Therefore we investigated the markers in a model of human endotoxemia intervened by increasing doses of prednisolone...
  86. ncbi Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions
    Hiromitsu Yamamoto
    Gifu Pharmaceutical University, 5 6 1, Mitahora higashi Gifu 502 8585, Japan
    J Control Release 102:373-81. 2005
    ..4000)>FD-21 (Mw. 21,000)>FD70 (Mw. 70,000), which corresponded to the molecular weights ([Mw.] given in parentheses). The absorption-enhancing effect may have been caused by opening the intercellular tight junctions...
  87. ncbi Procalcitonin for reduced antibiotic exposure in the critical care setting: a systematic review and an economic evaluation
    Daren K Heyland
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Crit Care Med 39:1792-9. 2011
    ..The purpose of this analysis was to evaluate the effect of a procalcitonin-guided antibiotic strategy on clinical and economic outcomes...
  88. pmc Procalcitonin is not sufficiently reliable to be the sole marker of neonatal sepsis of nosocomial origin
    José B López Sastre
    Service of Neonatology, Hospital Universitario Central de Asturias, Oviedo, Spain
    BMC Pediatr 6:16. 2006
    ..The aim of this prospective multicenter study was to assess the usefulness of PCT as a marker of neonatal sepsis of nosocomial origin...
  89. ncbi Diagnostic and prognostic biomarkers of sepsis in critical care
    Savitri Kibe
    Department of Infection and Tropical Medicine, Castle Hill Hospital, Hull and East Yorkshire Hospitals NHS Trust, Cottingham, East Yorkshire, UK
    J Antimicrob Chemother 66:ii33-40. 2011
    ..Many other biomarkers are currently being investigated. To be highly useful in clinical practice, it may be necessary to combine these with other novel biomarkers and/or traditional markers of sepsis...
  90. ncbi Individualization of lymph node dissection in RET (rearranged during transfection) carriers at risk for medullary thyroid cancer: value of pretherapeutic calcitonin levels
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Germany
    Ann Surg 250:305-10. 2009
    ..This study sought to define the need for lymph node dissection in Rearranged during Transfection (RET) carriers at risk for hereditary medullary thyroid cancer...
  91. ncbi Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats
    H Takeuchi
    Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Japan
    J Control Release 86:235-42. 2003
    ..The effectiveness of the liposomal formulations in oral administration of calcitonin was evaluated by measuring the change in the blood calcium concentration of rats...
  92. ncbi Clinical review 167: Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors
    K L Becker
    Veterans Affairs Medical Center and George Washington University, Washington, D C 20422, USA
    J Clin Endocrinol Metab 89:1512-25. 2004
  93. ncbi The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism
    D Naot
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Bone 43:813-8. 2008
    The 'calcitonin family' is a group of peptide hormones that share structural similarities with calcitonin, and includes calcitonin gene-related peptide (CGRP), amylin, adrenomedullin and adrenomedullin 2 (intermedin)...
  94. ncbi Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia
    Nicolas Boussekey
    Tourcoing Hospital, Intensive Care and Infectious Disease Unit, 135 rue du Président Coty BP 619, 59208, Tourcoing Cedex, France
    Intensive Care Med 32:469-72. 2006
    ..We analyzed the relationship between PCT kinetics and outcome in ICU patients with severe CAP...
  95. pmc Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study
    Sari Karlsson
    Department of Intensive Care Medicine, Tampere University Hospital, Teiskontie 35, 33521 Tampere, Finland
    Crit Care 14:R205. 2010
    ..This prospective study investigated the predictive value of procalcitonin (PCT) for survival in 242 adult patients with severe sepsis and septic shock treated in intensive care...
  96. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
    ..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
  97. ncbi Early and late markers for the detection of early-onset neonatal sepsis
    L Bender
    Department of Paediatrics, Aalborg Hospital, University of Aarhus, Aalborg, Denmark
    Dan Med Bull 55:219-23. 2008
    ..In this study we tested how a combination of early and late paraclinic markers could predict early onset neonatal sepsis (EONS)...
  98. ncbi Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study
    D Stolz
    Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Respir J 34:1364-75. 2009
    ..Serum procalcitonin reduces antibiotic therapy exposure in patients with ventilator associated pneumonia...
  99. pmc Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and the outcome
    Pierre Emmanuel Charles
    Service de Reanimation Medicale, Hopital Le Bocage, C, H, U, de Dijon, 21000 Dijon, France
    Crit Care 13:R38. 2009
    ..The potential interest of procalcitonin (PCT) as a way to assess the clinical efficacy of the empirical antibiotic therapy was addressed in the present study...
  100. ncbi Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma
    Jacques Barbet
    Département de Recherche en Cancérologie, Institut National de la Sante et de la Recherche Medicale, Unite 601, Institut de Biologie, 9 quai Moncousu, 44093 Nantes Cedex 1, France
    J Clin Endocrinol Metab 90:6077-84. 2005
    ..After unsuccessful surgery, medullary thyroid carcinoma (MTC) may be fatal or remain stable for decades, and precise survival predictors are needed...
  101. ncbi Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels
    Anne Laure Giraudet
    Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Clin Endocrinol Metab 92:4185-90. 2007
    Because calcitonin level remains elevated after initial treatment in many medullary thyroid carcinoma (MTC) patients without evidence of disease in the usual imaging work-up, there is a need to define optimal imaging procedures.

Research Grants65

  1. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Calcitonin gene-related peptide (CGRP) functions as an autocrine/paracrine factor, hormone and neuro- modulator...
  2. Controlled delivery of polypeptide hormone calcitonin
    Jagdish Singh; Fiscal Year: 2013
    ..b>Calcitonin isa polypeptide hormone with 32 amino acids and has a molecular mass of about 3500...
  3. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..are present in mucosal enteroendocrine cells that contain serotonin (5-HT) and sensory neurons containing calcitonin gene-related peptide (CGRP) and substance P (SP), and that BDNF acts to enhance 5-HT and CGRP release in ..
  4. The unique role of B-Raf in murine cardiac development and postnatal function
    Natasha N Chattergoon; Fiscal Year: 2013
    ..We determined that calcitonin gene-related peptide, a powerful vasodilator, is potent inhibitor of VSMC proliferation in vitro by stimulating ..
  5. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..vasodilation, plasma extravasation, and pain and is due largely to release of the neuropeptides substance P and calcitonin gene-related peptide (CGRP)...
  6. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2013
    ..including Ca2+/calmodulin-dependent protein kinase (CaMK)II, cAMP-response element binding protein (CREB), calcitonin gene-related peptide (CGRP), and cerebellin 1 precursor (Cbln1) in bladder afferent neurons before and during ..
  7. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
    ..Prominent examples include serotonin, histamine, adrenergic, muscarinic and calcitonin receptors which are targets of current and potentially new drugs...
  8. Role of TRP Channels in Environmental Irritant-Induced Headache
    Gerry S Oxford; Fiscal Year: 2013
    ..TRPA1 homomers, or TRPA1/TRPV1 heteromers on trigeminal neurons innervating the meninges results in release of calcitonin gene-related peptide (CGRP), a potent vasodilator implicated in migraine...
  9. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ..determine if neurogenic inflammation following CAP injection involves triggering DRRs that cause the release of calcitonin gene-related peptide and/or substance P from primary afferent nociceptors and if this process would in turn ..
  10. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..are present in mucosal enteroendocrine cells that contain serotonin (5-HT) and sensory neurons containing calcitonin gene-related peptide (CGRP) and substance P (SP), and that BDNF acts to enhance 5-HT and CGRP release in ..
  11. Neurogenic inflammation and psoriasiform dermatitis
    NICOLE LEANNE WARD; Fiscal Year: 2013
    ..provided by applicant): Psoriatic skin contains more nerve fibers and increased levels of sensory nerve-derived calcitonin gene related peptide (CGRP) and substance P (SP)...
  12. Inflammasome Activation in Complex Regional Pain Syndrome
    Wade S Kingery; Fiscal Year: 2013
    ..The project's specific aims are as follows: 1. We will test the hypothesis that substance P (SP), calcitonin gene related peptide (CGRP) and beta 2 adrenergic receptor agonists stimulate the production of key inflammasome ..
  13. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
    ..as an important component of stress regulation circuitry, contains dense terminals that release the neuropeptide calcitonin gene-related peptide (CGRP)...
  14. The role of stress and mast cells in a preclinical mouse model of migraine
    ANN CHRISTINE RADDANT; Fiscal Year: 2013
    ..b>Calcitonin gene-related peptide (CGRP) plays a critical role in migraine, as evidenced by recent success of CGRP ..
  15. METHYLATION OF THE CALCITONIN GENE IN HUMAN TUMORS
    Stephen B Baylin; Fiscal Year: 2013
    ..We investigate whether this change can foster cancer initiation and the molecular mechanisms though which it arises. ..
  16. CGRP-induced light aversion in a preclinical migraine model
    Andrew F Russo; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Migraine is a debilitating neurological condition involving the neuropeptide calcitonin gene-related peptide (CGRP)...
  17. Treat Neuropathic Pain with Dissolvable Microneedles Containing Anti-CGRP Peptide
    Xinmin Simon Xie; Fiscal Year: 2013
    ..b>Calcitonin Gene-Related Peptide (CGRP) appears to be critical in this process...
  18. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..NEP degrades natriuretic peptides as well as neuropeptides such as calcitonin gene-related peptide (CGRP) and bradykinin...
  19. Calcitonin in Prostate Growth and Neplasia
    Girish V Shah; Fiscal Year: 2013
    ..We and others have shown that all primary PCs and PC cell lines express calcitonin (CT) and/or its receptor (CTR), and their co-expression positively correlates with the tumor grade of primary ..
  20. NEURONAL CONTROL OF CGRP GENE EXPRESSION
    ANDREW RUSSO; Fiscal Year: 2009
    b>Calcitonin gene-related peptide (CGRP) has been implicated in craniofacial pain and headache by virtue of its expression in the trigeminal ganglion and roles in neurogenic inflammation and nociception...
  21. Sex Steroid Hormones and Calcitonin Gene-Related Peptide
    Chandrasekhar Yallampalli; Fiscal Year: 2013
    ..Peptides of the calcitonin gene-related peptide (CGRP)-family-CGRP, adrenomedullin (AM), and intermedin (IMD)-have been shown to play ..
  22. Calcitonin for treating X-linked hypophosphatemia
    KARL LEONARD INSOGNA; Fiscal Year: 2012
    ..As detailed in the Research Strategy, we have identified calcitonin as a novel suppressor of FGF23 production in XLH...
  23. Mechanisms of airway neurogenic inflammation by asthma-inducing allergens
    Armen N Akopian; Fiscal Year: 2013
    ..One of the possibilities is that neuropeptides such as substance P (SP) and calcitonin gene-related peptide (CGRP), which trigger neurogenic inflammation, could be released from sensory nerve ..
  24. pH Sensitive Complex Hydrogels for Protein Drug Release
    Nicholas A Peppas; Fiscal Year: 2013
    ..henceforth designated as P (MAA-g-EG), have shown extreme promise as oral delivery vehicles for insulin, calcitonin, and growth hormone...
  25. Maintenance therapy with decitabine for acute myeloid leukemia in first remission
    William G Blum; Fiscal Year: 2010
    ..Many genes are frequently methylated in acute myeloid leukemia (AML) including p15, estrogen receptor (ER), and calcitonin, among others...
  26. RAMP-altered Class B GPCR Hormone Recognition
    Augen A Pioszak; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The human calcitonin (CTR) and calcitonin-like (CLR) receptors are cell-surface class B G protein-coupled receptors (GPCRs) that associate with receptor activity modifying protein (RAMP) co-receptors ..
  27. Adrenomedullin Signaling at the Maternal-Fetal Interface
    Kathleen M Caron; Fiscal Year: 2013
    ..peptide vasodilator adrenomedullin (AM) typically signals through a G-protein coupled receptor (GPCR) called calcitonin receptor-like receptor (Calcrl) when the receptor is bound to a novel class of proteins called receptor activity ..
  28. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2013
    Medullary thyroid cancer (MTC) is a neuroendocrine tumor derived from the calcitonin-producing thyroid C-cells and accounts for 3-5% of cases of thyroid cancer...
  29. Coronary Dysregulation Associated with Obesity
    Christine L Oltman; Fiscal Year: 2013
    ..b>Calcitonin gene-related peptide (CGRP) is a very potent physiological microvascular dilator...
  30. Ethanol Prevents Microvascular Dysfunction
    Ronald J Korthuis; Fiscal Year: 2010
    ..of an anti-inflammatory phenotype by stimulating the formation of eNOS-derived NO;(2) NO-induced release of calcitonin gene-related peptide (CGRP) plays an essential role in the acquisition of tolerance to ischemia that is evoked ..
  31. Community-Based, Phase III Trial of acupuncture to treat chronic Xerostomia
    Lorenzo Cohen; Fiscal Year: 2013
    ..on saliva based factors including pH, buffering capacity, and viscosity as well as levels of total protein, calcitonin- gene-related peptide (CGRP), and vasoactive intestinal polypeptide (VIP);and 6...
  32. Cell Biology of Vasopressin-Induced Water Channels
    Dennis Brown; Fiscal Year: 2013
    ..Aim 2 will first expand our promising work on phosphodiesterase (PDE5) inhibitors, calcitonin and statins, which promote AQP2 membrane accumulation and increase urine concentration...
  33. AMY-1 receptors: Novel targets for antipsychotic development
    Brian A Baldo; Fiscal Year: 2012
    ..This receptor binds members of the calcitonin family of peptides, including amylin, salmon calcitonin, and calcitonin gene-related peptide (CGRP)...
  34. The Responses of Thermoregulatory Neurons to CGRP
    John Griffin; Fiscal Year: 2009
    ..This transient hyperthermic shift in body temperature has been linked to the neuropeptide calcitonin gene-related peptide (CGRP), which acts peripherally to increase vasodilation and centrally to increase ..
  35. Role of CGRP in the association between migraine and obesity
    ANA RECOBER-MONTILLA; Fiscal Year: 2013
    ..The objective of this proposal is to test the concept that calcitonin gene-related peptide (CGRP) represents a biological link between obesity and migraine...
  36. Role of RAMPs in Intermedin Signaling
    Sheau Yu Teddy Hsu; Fiscal Year: 2010
    ..Functional studies showed that intermedin signals through a G protein-coupled receptor, calcitonin receptor-like receptor (CLR)...
  37. Calcitonin Regulation of Osteoclast Integrin Functions
    ROLAND E BARON; Fiscal Year: 2013
    b>Calcitonin (CT) is the most potent and rapidly acting known inhibitor of bone resorption that targets the osteoclast (OC) directly...
  38. Genetic targeting of CGRP actions in a murine model of migraine
    ERIC ALAN KAISER; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Migraine is a highly prevalent and disabling neurological pain disorder. Calcitonin gene-related peptide (CGRP) is now strongly implicated in migraine;however, its exact role in the pathophysiology of ..
  39. Actions of Endoxifen on the Skeleton
    Anne Gingery; Fiscal Year: 2013
    ..Present day therapies involve anti-resorptive agents such as bisphosphonates, estrogen analogs, raloxifene and calcitonin which primarily target bone resorbing osteoclasts resulting in reduced bone turnover...
  40. Epithelial Stem Cells in Lung Transplantation
    Kalpaj Parekh; Fiscal Year: 2013
    ..Specifically, this proposal will focus on the contribution of denervation to aberrant calcitonin gene related peptide (CGRP) neuropeptide responses that control stem cell proliferation in the airways...
  41. Assessing Clinical Equivalence for Generic Drugs Approved By Innovative Methods
    Aaron Seth Kesselheim; Fiscal Year: 2013
    ..the FDA's bioequivalence determination in 6 specific circumstances: the approval of generic venlafaxine ER, calcitonin salmon nasal spray, enoxaparin, acarbose, vancomycin capsules, and sodium ferric gluconate...
  42. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    ..inflammation, as measured by reduction of capsaicin-evoked release of the pro-inflammatory neuropeptide calcitonin gene-related peptide (CGRP) from superfused dental pulp...
  43. Mouse model of vestibulodynia using recurrent vulvovaginal Candidiasis
    MELISSA ANNE FARMER; Fiscal Year: 2010
    ..5 immunohistochemistry) and markers of nociception (via calcitonin gene related peptide and the vanilloid receptor TRPV1);(c) to examine the immunological profile of vulvar tissue ..
  44. Peptide Modulation of Physiology and Behavior
    Michael N Nitabach; Fiscal Year: 2013
    ..signal through cAMP in fly circadian/sleep control circuits: PDF (Pigment Dispersing Factor), DH31 (fly calcitonin homologue), and DH44 (fly corticotropin releasing factor (CRF) homologue)...
  45. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2001
    ..We propose to use a combination of human calcitonin (hCT) and polymer-bound cathepsin K inhibitor (CKI) as a novel treatment of osteoporosis...
  46. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2003
    ..We propose to use a combination of human calcitonin (hCT) and polymer-bound cathepsin K inhibitor (CKI) as a novel treatment of osteoporosis...
  47. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..increases the number of trigeminal ganglion (TG) muscle afferent neurons that express: substance P (SP), calcitonin gene-related peptide (CGRP), neurokinin-1 receptor (NK-lr) and CGRP receptor (CGRPr)...
  48. Radiation-Induced Heart Disease: Mechanisms and Interventions
    Marjan Boerma; Fiscal Year: 2013
    ..hormone that is formed by mast cell proteinases;and 3) the cardioprotective sensory neuropeptide calcitonin gene-related peptide (CGRP), as part of the neuroimmune interactions that are known to alter cardiac function ..
  49. ProACT Planning Grant
    DAVID TOM HUANG; Fiscal Year: 2013
    ..Procalcitonin is a calcitonin precursor elevated in bacterial, but not viral, infection...
  50. TUMOR CELL SYNTHESIS AND SECRETION OF PEPTIDE HORMONES
    David Orth; Fiscal Year: 1991
    ..Because nonpituitary tumor secretion of POMC peptides is often associated with that of calcitonin (CT), arginine vasopressin (AVP), and gastrin-releasing peptide (GRP) and because corticotropin-releasing ..
  51. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
    This proposal examines the general hypothesis that the neuropeptides substance P (SP) and calcitonin-gene related peptide (CGRP) act in a co-operative fashion to induce neurogenic inflammation of the intestine...
  52. BRAIN REGULATING GASTRIC ACID FUNCTION BY NEUROPEPTIDES
    YVETTE TACHE; Fiscal Year: 2000
    ..vagal cholinergic gastric hyperemic response to central injection of TRH was shown to be mediated by capsaicin- calcitonin gene-related peptide (CGRP) and nitric oxide dependent mechanisms...
  53. Procalcitonin Antibiotic Consensus Trial (ProACT)
    DAVID TOM HUANG; Fiscal Year: 2013
    ..Procalcitonin is a calcitonin precursor elevated in bacterial infection, but not viral...
  54. Ontogeny of CRLR and RAMPs in Myometrium
    Chandrasekhar Yallampalli; Fiscal Year: 2002
    ..In the absence or imbalance of these molecules within the uterus, fetus will be delivered prematurely. Calcitonin gene-related peptide (CGRP) is the most potent smooth muscle relaxant peptide known, and is also a major ..
  55. REGULATION OF PARATHYROID HORMONE AND CALCITONIN GENES
    Justin Silver; Fiscal Year: 1991
    The main goal of this research proposal is to understand how the PTH and calcitonin genes are regulated...
  56. ECDYSTEROID REGULATION OF INVERTEBRATE CALCITONIN
    LAURENS SMITH; Fiscal Year: 1993
    ..and hormonal regulators, particularly the gonadal steroids such as estrogen, and peptide hormones including calcitonin (CT)...
  57. CALCITONIN RECEPTOR GENE EXPRESSION
    Steven Goldring; Fiscal Year: 2002
    Our initial application proposed to study the mechanism of action and regulation of the calcitonin receptor (CTR) gene...
  58. DYNORPHIN MODULATES CGRP RELEASE VIA PKC
    Zaijie Jim Wang; Fiscal Year: 2003
    ..Both dynorphin and activation of PKC were found to augment capsaicin-evoked calcitonin gene-related peptide (CGRP) release, characteristic of activation of primary afferent fibers...
  59. Intermedin / AM2 in Human Pregnancy
    MADHU LATA CHAUHAN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Calcitonin (CT), calcitonin gene related peptide CGRP, amylin and adrenomedullin (AM) belong to a unique group of peptide, hormones, important for homeostasis...
  60. REGULATION OF ALTERNATIVE PROCESSING OF CALCITONIN/CGRP
    Susan Berget; Fiscal Year: 2002
    ..The gene under study is that coding for the peptide hormones calcitonin (CT) and calcitonin-gene-related peptide (CGRP)...
  61. MARKERS OF ENDOMETRIAL RECEPTIVITY DURING IMPLANTATION
    INDRANI BAGCHI; Fiscal Year: 2000
    ..The Specific Aims of this proposal are: (1) To examine the temporal and spatial expression of calcitonin in human endometrium during the menstrual cycle...
  62. PARACRINE INTERACTIONS IN PROLACTIN SECRETION
    Girish Shah; Fiscal Year: 1999
    ..Previous studies from this laboratory have shown that calcitonin- like immunoreactive peptide (pit-CT) is synthesized and secreted by cultured AP cells...
  63. INDUCIBLE ALTERATION OF CGRP IN PRIMARY AFFERENT NEURONS
    KARIN WESTLUND HIGH; Fiscal Year: 1993
    ..to test the existence of inducible alterations in peptide content in primary afferent/autonomic pathways calcitonin gene-related peptide (CGRP)...
  64. CALCITONIN GENE-RELATED PEPTIDE IN HYPERTENSION
    Gianfranco Alpini; Fiscal Year: 2006
    ..abstract_text> ..
  65. CONTROL OF NEUROENDOCRINE GENE EXPRESSION
    STUART LEFF; Fiscal Year: 1992
    ..project proposes to study the mechanisms by which cell- specific expression of the neuro- and endocrine peptides calcitonin and calcitonin gene-related peptide (CGRP) is determined at a transcriptional and post-transcriptional level...