atrial natriuretic factor

Summary

Summary: A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.

Top Publications

  1. ncbi A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
    J D Molkentin
    Department of Molecular Biology and Oncology, The University of Texas Southwestern Medical Center at Dallas, 75225 9148, USA
    Cell 93:215-28. 1998
  2. ncbi A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    B G Bruneau
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 106:709-21. 2001
  3. ncbi Impact of obesity on plasma natriuretic peptide levels
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 109:594-600. 2004
  4. ncbi Neuroendocrine control of body fluid metabolism
    Jose Antunes-Rodrigues
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Physiol Rev 84:169-208. 2004
  5. ncbi A new natriuretic peptide in porcine brain
    T Sudoh
    Department of Biochemistry, Miyazaki Medical College, Japan
    Nature 332:78-81. 1988
  6. ncbi Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial
    Alan Maisel
    VA San Diego Healthcare System, San Diego, California 92161, USA
    J Am Coll Cardiol 55:2062-76. 2010
  7. pmc NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function
    Koichiro Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    EMBO J 22:6310-21. 2003
  8. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
  9. ncbi Kir6.2-deficient mice are susceptible to stimulated ANP secretion: K(ATP) channel acts as a negative feedback mechanism?
    Noriko Saegusa
    Department of Pharmacology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Cardiovasc Res 67:60-8. 2005
  10. pmc Hypertension in mice lacking the proatrial natriuretic peptide convertase corin
    Joyce C Y Chan
    Berlex Biosciences, Richmond, CA 94804, USA
    Proc Natl Acad Sci U S A 102:785-90. 2005

Detail Information

Publications291 found, 100 shown here

  1. ncbi A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
    J D Molkentin
    Department of Molecular Biology and Oncology, The University of Texas Southwestern Medical Center at Dallas, 75225 9148, USA
    Cell 93:215-28. 1998
    ..Pharmacologic inhibition of calcineurin activity blocks hypertrophy in vivo and in vitro. These results define a novel hypertrophic signaling pathway and suggest pharmacologic approaches to prevent cardiac hypertrophy and heart failure...
  2. ncbi A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    B G Bruneau
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 106:709-21. 2001
    ..Surprisingly, Tbx5 haploinsufficiency also markedly decreased atrial natriuretic factor (ANF) and connexin 40 (cx40) transcription, implicating these as Tbx5 target genes and providing a ..
  3. ncbi Impact of obesity on plasma natriuretic peptide levels
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 109:594-600. 2004
    ..The natriuretic peptides are important regulators of sodium homeostasis and neurohormonal activation, raising the possibility that obese individuals have an impaired natriuretic peptide response...
  4. ncbi Neuroendocrine control of body fluid metabolism
    Jose Antunes-Rodrigues
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Physiol Rev 84:169-208. 2004
    ..This review emphasizes the role played by brain ANP and its interaction with neurohypophysial hormones in the control of body fluid homeostasis...
  5. ncbi A new natriuretic peptide in porcine brain
    T Sudoh
    Department of Biochemistry, Miyazaki Medical College, Japan
    Nature 332:78-81. 1988
    ..The occurrence of BNP with ANP in mammalian brain suggests the possibility that the physiological functions so far thought to be mediated by ANP may be regulated through a dual mechanism involving both ANP and BNP...
  6. ncbi Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial
    Alan Maisel
    VA San Diego Healthcare System, San Diego, California 92161, USA
    J Am Coll Cardiol 55:2062-76. 2010
    ....
  7. pmc NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function
    Koichiro Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    EMBO J 22:6310-21. 2003
    ..Our results indicate NRSF to be a key transcriptional regulator of the fetal cardiac gene program and suggest an important role for NRSF in maintaining normal cardiac structure and function...
  8. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
    ..85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension...
  9. ncbi Kir6.2-deficient mice are susceptible to stimulated ANP secretion: K(ATP) channel acts as a negative feedback mechanism?
    Noriko Saegusa
    Department of Pharmacology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Cardiovasc Res 67:60-8. 2005
    ..We sought to determine whether the ATP-sensitive K+ (K(ATP)) channel modulates the secretion of ANP, using mice with homozygous knockout of the Kir6.2 (a pore-forming subunit of cardiac K(ATP) channel) gene...
  10. pmc Hypertension in mice lacking the proatrial natriuretic peptide convertase corin
    Joyce C Y Chan
    Berlex Biosciences, Richmond, CA 94804, USA
    Proc Natl Acad Sci U S A 102:785-90. 2005
    ..Thus, our data establish corin as the physiological pro-ANP convertase and indicate that corin deficiency may contribute to hypertensive heart disease...
  11. ncbi Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    Hypertension 39:81-6. 2002
    ..In conclusion, we provide the first evidence that DNJun inhibits cardiomyocyte hypertrophy through inhibition of AP-1 transcriptional activity...
  12. ncbi Small cytoplasmic domain peptides of natriuretic peptide receptor-C attenuate cell proliferation through Gialpha protein/MAP kinase/PI3-kinase/AKT pathways
    Shehla Hashim
    Dept of Physiology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada H3C 3J7
    Am J Physiol Heart Circ Physiol 291:H3144-53. 2006
    ....
  13. ncbi Haemodynamic and clinical effects of ularitide in decompensated heart failure
    Veselin Mitrovic
    Kerckhoff Klinik, Bad Nauheim, Germany
    Eur Heart J 27:2823-32. 2006
    ..We assessed the efficacy and safety of ularitide in treating patients with DHF...
  14. ncbi Effect of high and low sodium intake on urinary aquaporin-2 excretion in healthy humans
    Carolina Cannillo Graffe
    Dept of Medical Research, Holstebro Hospital, Holstebro, Denmark
    Am J Physiol Renal Physiol 302:F264-75. 2012
    ..In conclusion, u-AQP2 was increased during HS intake, indicating that water transport via AQP2 was increased. The effect was mediated by an unknown AVP-independent mechanism...
  15. ncbi Effect of atrial natriuretic peptide on left ventricular remodelling in patients with acute myocardial infarction
    Shu Kasama
    Department of Cardiovascular Medicine, Gunma University School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 0034, Japan
    Eur Heart J 29:1485-94. 2008
    ..ANP has a variety of cardioprotective effects and is considered to be a very promising adjunct drug for the reperfusion therapy in patients with AMI...
  16. ncbi Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart
    Takeshi Tokudome
    Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 117:2329-39. 2008
    ..In the present report, we examined the role of regulator of G-protein signaling subtype 4 (RGS4), a GTPase activating protein for G(q) and G(i), in the antihypertrophic effects of GC-A...
  17. pmc A genetic variant of the atrial natriuretic peptide gene is associated with cardiometabolic protection in the general community
    Valentina Cannone
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 58:629-36. 2011
    ..We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene...
  18. ncbi Protein-enriched diet increases water absorption via the aquaporin-2 water channels in healthy humans
    Thomas Guldager Lauridsen
    Department of Medicine, Department of Medical Research, Regional Hospital Holstebro, Lagaardvej 12, Holstebro, Denmark
    Nephrol Dial Transplant 25:2502-10. 2010
    ....
  19. ncbi Effects of carperitide on the long-term prognosis of patients with acute decompensated chronic heart failure: the PROTECT multicenter randomized controlled study
    Noritake Hata
    Department of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Inba gun, Chiba, Japan
    Circ J 72:1787-93. 2008
    ..Carperitide is used to treat acute decompensated heart failure (ADHF), but its effects on long-term prognosis have not been studied...
  20. ncbi Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells
    Chung Jung Liu
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
    Mol Cell Biochem 313:167-78. 2008
    ..Our findings further provide a link between the LPS-induced inflammatory response and the calcineurin/NFAT-3 signaling pathway that mediates the development of cardiac hypertrophy...
  21. ncbi Adenine nucleotides decrease the apparent Km of endogenous natriuretic peptide receptors for GTP
    Laura K Antos
    Dept of Biochemistry, Molecular Biology and Biophysics, Univ of Minnesota, 6 155 Jackson, 321 Church St SE, Minneapolis, MN 55455, USA
    Am J Physiol Endocrinol Metab 293:E1756-63. 2007
    ..We conclude that ATP is not required for the initial activation of NPRs but does increase activity over time by reducing the apparent K(m) for GTP...
  22. ncbi The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases
    Kunhua Song
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Cell 125:453-66. 2006
    ..regulators of cardiac hypertrophy, we performed a eukaryotic expression screen for activators of the atrial natriuretic factor (ANF) gene, a cardiac-specific marker of hypertrophic signaling...
  23. ncbi ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice
    H A Rockman
    Department of Medicine, University of California San Diego School of Medicine, La Jolla 92093
    Am J Physiol 266:H2468-75. 1994
    ..The increase in heart weight-to-body weight ratio was also significantly attenuated by captopril compared with untreated banded controls (0.542 +/- 0.091, g/g x 100, P = 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. ncbi Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Circulation 106:2091-7. 2002
    ..Structural changes, like atrial fibrosis, may increase the likelihood of atrial fibrillation (AF) occurring in response to triggering events. The influence of isolated atrial amyloidosis (IAA) is largely unknown...
  25. ncbi Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals
    Thomas J Wang
    Cardiology Division, GRB 800, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Circulation 115:1345-53. 2007
    ..Although it has been shown that obese individuals have reduced natriuretic peptide levels, conflicting data exist on the relation of natriuretic peptide levels to other metabolic risk factors...
  26. ncbi Thirty years of the heart as an endocrine organ: physiological role and clinical utility of cardiac natriuretic hormones
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, Fondazione CNR Regione Toscana G Monasterio, Scuola Superiore Sant Anna, Via Trieste 41, 56126 Pisa, Italy
    Am J Physiol Heart Circ Physiol 301:H12-20. 2011
    ..Finally, we will review the pathophysiological role and the clinical relevance of both peripheral maturation of the precursor of B-type natriuretic peptides and hormone signal transduction...
  27. ncbi Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice
    Pankaj Shende
    Department of Biomedicine, University of Basel and University Hospital Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Circulation 123:1073-82. 2011
    ..It is found in 2 structurally and functionally distinct multiprotein complexes called mTOR complex (mTORC) 1 and mTORC2. The role of each of these branches of mTOR signaling in the adult heart is currently unknown...
  28. ncbi Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors
    Christopher L Antos
    Department of Molecular Biology, The University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    J Biol Chem 278:28930-7. 2003
    ..HDAC inhibitors are currently being tested in clinical trials as anti-cancer agents. Our results suggest that these inhibitors may also hold promising clinical value as therapeutics for cardiac hypertrophy and heart failure...
  29. ncbi Mechanisms of atrial structural changes caused by stretch occurring before and during early atrial fibrillation
    Anne Margreet de Jong
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Cardiovasc Res 89:754-65. 2011
    ..Ultimately, knowledge of mechanisms underlying structural remodelling may help to identify new pharmacological targets for AF prevention...
  30. ncbi Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue
    C Moro
    INSERM, U586, Obesity Research Unit, Toulouse, France
    Diabetologia 50:1038-47. 2007
    ....
  31. ncbi The role of natriuretic peptides in cardioprotection
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Cardiovasc Res 69:318-28. 2006
    ..In a clinical setting, human recombinant ANP and BNP may be used for a therapy of heart failure; however, further evaluation is required in the future...
  32. ncbi Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure
    Alan S Maisel
    University of California, San Diego, Veterans Affairs Medical Center, San Diego 92161, USA
    N Engl J Med 347:161-7. 2002
    ..B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension...
  33. pmc Novel and conventional biomarkers for prediction of incident cardiovascular events in the community
    Olle Melander
    Department of Clinical Sciences, Lund University, Clinical Research Center, Malmo University Hospital, SE 205 02 Malmo, Sweden
    JAMA 302:49-57. 2009
    ..Prior studies have demonstrated conflicting results regarding how much information novel biomarkers add to cardiovascular risk assessment...
  34. ncbi N-terminal pro-brain natriuretic peptide. A new gold standard in predicting mortality in patients with advanced heart failure
    R S Gardner
    The Scottish Cardiopulmonary Transplant Unit, Glasgow Royal Infirmary, Glasgow, UK
    Eur Heart J 24:1735-43. 2003
    ..The purpose of this study was to examine the prognostic ability of NT-proBNP in advanced heart failure and compare it to that of the LVEF, peak VO2 and the HFSS...
  35. ncbi Diagnostic accuracy and prognostic relevance of the measurement of cardiac natriuretic peptides: a review
    Aldo Clerico
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Endocrinology, Pisa, Italy
    Clin Chem 50:33-50. 2004
    ..Authors have sought to evaluate the diagnostic accuracy and prognostic relevance of the measurement of CNHs according to evidence-based laboratory medicine principles...
  36. ncbi Concomitant recovery of atrial mechanical and endocrine function after cardioversion in patients with persistent atrial fibrillation
    Beata Wożakowska-Kapłon
    Department of Cardiology, Regional District Hospital, ul Grunwaldzka 45, 25 736 Kielce, Poland
    J Am Coll Cardiol 41:1716-20. 2003
    ..The purpose of this study was to evaluate left atrial mechanical function recovery and plasma atrial natriuretic peptide (ANP) release following successful cardioversion of persistent atrial fibrillation (AF)...
  37. ncbi Prediction of atrial fibrillation after coronary artery bypass grafting by measuring atrial peptide levels and preoperative atrial dimensions
    T Hakala
    Department of Thoracic and Cardiovascular Surgery, Kuopio University Hospital, Kuopio, Finland
    Eur J Cardiothorac Surg 22:939-43. 2002
    ....
  38. ncbi Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes
    Erol Saygili
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Kerpenerstr 62, 50924 Cologne, Germany
    Am J Physiol Heart Circ Physiol 292:H2898-905. 2007
    ..Stretch significantly increased protein-to-DNA ratio and atrial natriuretic factor mRNA expression, indicating hypertrophy...
  39. ncbi Multicenter prospective investigation on efficacy and safety of carperitide as a first-line drug for acute heart failure syndrome with preserved blood pressure: COMPASS: Carperitide Effects Observed Through Monitoring Dyspnea in Acute Decompensated Heart
    Fumihiro Nomura
    Marketing Department, Marketing and Sales Division, Daiichi Sankyo Company Limited, Chuo Ku, Tokyo, Japan
    Circ J 72:1777-86. 2008
    ..Although carperitide (alpha-human atrial natriuretic peptide) has vasodilatory, diuretic and organ-protective effects, its efficacy and safety for the first-line drug treatment of AHFS have not been reported...
  40. ncbi Defective regulation and action of atrial natriuretic peptide in type 2 diabetes
    M Nannipieri
    Metabolism Unit of the C N R Institute of Clinical Physiology, University of Pisa School of Medicine, Via Savi 8, 56100 Pisa, Italy
    Horm Metab Res 34:265-70. 2002
    ..We conclude that ANP release is resistant to volume stimulation in type 2 diabetic patients, and natriuresis is resistant to ANP action. This dual disruption of ANP control may play a role in blood pressure regulation in diabetes...
  41. ncbi A review of the role of atrial natriuretic peptide gene polymorphisms in hypertension and its sequelae
    Amy I Lynch
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Curr Hypertens Rep 11:35-42. 2009
    ..This report provides a comprehensive review of studies exploring NPPA polymorphisms in relation to hypertension and hypertension-related outcomes...
  42. pmc Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling
    P Paradis
    Laboratoire de developpement et differenciation cardiaques, Institut de Recherches Cliniques de Montreal, Montreal, QC Canada H2W 1R7
    Proc Natl Acad Sci U S A 97:931-6. 2000
    ..mice displayed significant cardiac hypertrophy and remodeling with increased expression of ventricular atrial natriuretic factor and interstitial collagen deposition and died prematurely of heart failure...
  43. ncbi The lipid-mobilizing effect of atrial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men
    J Galitzky
    Department of Clinical and Medical Pharmacology, , 31073 Toulouse Cedex, France
    J Lipid Res 42:536-44. 2001
    ..These data show that ANP is a potent lipolytic hormone independent of the activation of the sympathetic nervous system, and that obesity did not modify the lipid-mobilizing effect of ANP in young obese subjects...
  44. ncbi Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans
    Speranza Rubattu
    IRCCS Neuromed, Localita Camerelle, 86077 Pozzilli, Italy
    Stroke 35:814-8. 2004
    ..The purpose of the present study was to investigate the contributory role of the genes encoding atrial natriuretic peptide (ANP) and type A natriuretic peptide receptor (NPRA) in humans' susceptibility to develop ischemic stroke...
  45. ncbi Molecular heterogeneity has a major impact on the measurement of circulating N-terminal fragments of A- and B-type natriuretic peptides
    Minna Ala-Kopsala
    Department of Physiology, Biocenter Oulu, University of Oulu, Finland
    Clin Chem 50:1576-88. 2004
    ..The current assays require refinement with regard to standardization with native calibrators and the ability to detect the actual circulating forms...
  46. ncbi Atrial natriuretic peptide influence on nitric oxide system in kidney and heart
    María de los Angeles Costa
    Catedra de Fisiologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, IQUIMEFA CONICET, Junin 956, Piso 7, 1113 Capital Federal, Argentina
    Regul Pept 118:151-7. 2004
    ..This effect would be independent on the hemodynamic changes induced by ANP. The activation of NO pathway would be one of the mechanisms involved in diuretic, natriuretic and hypotensive effects of ANP...
  47. ncbi Natriuretic peptides and right atrial fibrosis in patients with paroxysmal versus persistent atrial fibrillation
    Hailong Cao
    Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing, Jiangsu Province 210029, China
    Peptides 31:1531-9. 2010
    ....
  48. ncbi Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension
    Joseph Fomusi Ndisang
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    J Pharmacol Exp Ther 334:87-98. 2010
    ..The potent renoprotection of HA could be explored to combat renal hypertrophy and histopathological lesions characteristic of ESRD...
  49. ncbi Thirty years of research on atrial natriuretic factor: historical background and emerging concepts
    Adolfo J De Bold
    Cardiovascular Endocrinology Laboratory, University of Ottawa Heart Institute, and Department of Pathology and Laboratory Medicine, University of Ottawa, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada
    Can J Physiol Pharmacol 89:527-31. 2011
    ..of an endocrine function of the heart that is now known to be mediated by the polypeptide hormones atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP)...
  50. ncbi Plasma NT-proANP in patients with persistent atrial fibrillation who underwent successful cardioversion
    Radosław Bartkowiak
    1st Department of Cardiology, Centre of Cardiology, Kielce, Poland
    Kardiol Pol 68:48-54. 2010
    ..In vitro degradation is also slower and NT-proANP may be an interesting alternative for ANP...
  51. ncbi Increased plasma levels of NT-proANP and NT-proBNP as markers of cardiac dysfunction in septic patients
    Ursula Hoffmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Lab 51:373-9. 2005
    ..71; p<0.001). NT-proANP and NT-proBNP may serve as useful laboratory markers to indicate myocardial dysfunction and may help to differentiate between survivors and non-survivors of severe sepsis...
  52. ncbi Involvement of atrial natriuretic peptide in blood pressure reduction induced by estradiol in spontaneously hypertensive rats
    Najara O Belo
    Department of Physiology and Biophysics, Institute of Biological Science, Federal University of Minas Gerais, Av Antonio Carlos, 6627, Belo Horizonte, MG CEP 31270 901, Brazil
    Regul Pept 117:53-60. 2004
    ..This reduction was highly correlated with increased plasma estradiol and ANP levels. These results suggest that ANP is involved in mediating the effect of estradiol on blood pressure reduction...
  53. pmc Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload
    O Nakagawa
    Department of Medicine, Kyoto University Faculty of Medicine, Japan
    J Clin Invest 96:1280-7. 1995
    ....
  54. ncbi Signaling pathways involved in atrial natriuretic factor and dopamine regulation of renal Na+, K+ -ATPase activity
    Alicia H Correa
    Cátedras de Fisiopatología, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, IQUIFIB CONICET, Junín 956 piso 5, 1113 Buenos Aires, Argentina
    Regul Pept 138:26-31. 2007
    Dopamine (DA) and atrial natriuretic factor (ANF) share a number of physiological effects. We hypothesized that ANF and the renal dopaminergic system could interact and enhance the natriuretic and diuretic effects of the peptide...
  55. ncbi The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo
    O F Bueno
    Department of Pediatrics, University of Cincinnati, Children's Hospital Medical Center, Division of Molecular Cardiovascular Biology, Cincinnati, Ohio, USA
    Circ Res 88:88-96. 2001
    ....
  56. ncbi Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK
    Sandra C Souza
    Translational Sciences Translational Medicine, Novartis Institutes for BioMedical Research, Inc, 220 Massachusetts Avenue, Cambridge, MA 02139, USA
    Biochem Biophys Res Commun 410:398-403. 2011
    ..These results show that ANP regulates lipid catabolism and enhances energy dissipation through AMPK activation in human adipocytes...
  57. ncbi Neuroendocrine profiling of humans receiving cardiac allografts
    Tsuneo Ogawa
    Cardiovascular Endocrinology Laboratory, University of Ottawa Heart Institute, Ontario, Canada
    J Heart Lung Transplant 24:1046-54. 2005
    ..As a result, plasma levels of various hormones and autocoids have been associated with cardiac allograft rejection status. However, no clear associations can be defined given the highly contradictory nature of the available literature...
  58. ncbi Midregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic stroke
    Mira Katan
    Department of Endocrinology, University Hospital Basel, Basel, Switzerland
    J Am Coll Cardiol 56:1045-53. 2010
    ..The purpose of this study was to examine the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) in patients with acute ischemic stroke...
  59. pmc The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis
    Li Chun Lisa Tsai
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Curr Opin Pharmacol 11:670-5. 2011
    ..In addition to cAMP-dependent pathways, cGMP signaling also can promote steroidogenesis, and PDE5 modulates this process. Finally, PDE mutations may lead to several human diseases characterized by abnormal steroid levels...
  60. ncbi Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I
    A Smolenski
    Institut für Klinische Biochemie und Pathobiochemie, Medizinische Universitatsklinik, Wurzburg, Germany
    J Biol Chem 275:25723-32. 2000
    ..These results indicate that cGK I phosphorylation of VASP results in loss of VASP and zyxin from focal adhesions, a response that could contribute to cGK alteration of cytoskeleton-regulated processes such as cell migration...
  61. ncbi Natriuretic peptide receptor: structure and signaling
    Kunio S Misono
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Mol Cell Biochem 230:49-60. 2002
    ....
  62. ncbi Ouabain-insensitive Na+-ATPase of proximal tubules is an effector for urodilatin and atrial natriuretic peptide
    C Caruso-Neves
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21949 900 Rio de Janeiro, RJ, Brazil
    Biochim Biophys Acta 1660:93-8. 2004
    ..The data obtained indicate that this effect is mediated by the activation of the NPR-A/guanylate cyclase/cGMP pathway...
  63. ncbi Effects of adrenomedullin on cultured rat cardiac myocytes and fibroblasts
    T Horio
    Division of Hypertension, Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Japan
    Eur J Pharmacol 382:1-9. 1999
    ....
  64. pmc Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume
    Fitz Roy E Curry
    Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, Davis, CA 95616, USA
    J Physiol 588:325-39. 2010
    ..These quantitative methods will enable further evaluation of the contribution of ANP-dependent microvascular beds (such as gastro-intestinal tract) to plasma volume regulation...
  65. ncbi Atrial natriuretic peptides and urodilatin modulate proximal tubule Na(+)-ATPase activity through activation of the NPR-A/cGMP/PKG pathway
    Diogo Vives
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS Bloco G, 21941 902 Rio de Janeiro, RJ, Brazil
    Peptides 31:903-8. 2010
    ....
  66. ncbi The role of atrial natriuretic peptide in the immune system
    Angelika M Vollmar
    Department of Pharmacy, Center for Drug Research, Ludwig Maximilians University of Munich, Butenandtstr 5 11, 81375 Munich, Germany
    Peptides 26:1086-94. 2005
    ..In fact, this review focus on effects of ANP in the immune system and reports about the role of the peptide in innate immune functions as well as in the adaptive immune response...
  67. ncbi Cell-specific activation of the atrial natriuretic factor promoter by PITX2 and MEF2A
    Rafael Toro
    Genetics Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 279:52087-94. 2004
    ..To study the functional significance of this interaction, we used the atrial natriuretic factor (ANF) promoter...
  68. ncbi Influence of ScaI and natriuretic peptide (NP) clearance receptor polymorphisms of the NP System on NP concentration in chronic heart failure
    Cristina Vassalle
    Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Pisa, Italy
    Clin Chem 53:1886-90. 2007
    ..Despite the importance of NPs in heart failure (HF), the role of these polymorphisms in HF has not been evaluated...
  69. ncbi Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor
    Min Su Kim
    Department of Cell Biology, Neurobiology, and Anatomy and the Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 281:15082-9. 2006
    ..SRF) and by transient transfection assessments showing that Tip60 and SRF cooperatively activate the atrial natriuretic factor promoter...
  70. ncbi B-type natriuretic peptide and amino-terminal atrial natriuretic peptide predict survival in peritoneal dialysis
    Joost H W Rutten
    Department of Internal Medicine Erasmus MC, Rotterdam, The Netherlands
    Perit Dial Int 26:598-602. 2006
  71. ncbi C-type natriuretic peptide in human coronary atherosclerotic lesions
    T Naruko
    Department of Cardiovascular Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 94:3103-8. 1996
    ..Since these features play a role in atherogenesis, the presence of CNP at such sites was studied...
  72. ncbi Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in predicting survival in patients with chronic heart failure
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    J Am Coll Cardiol 50:1973-80. 2007
    ..Our aim was assess the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) using a new immunoassay in patients with chronic heart failure (HF)...
  73. ncbi A rapid B-type natriuretic peptide assay accurately diagnoses left ventricular dysfunction and heart failure: a multicenter evaluation
    Stacey J Wieczorek
    Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, Conn, USA
    Am Heart J 144:834-9. 2002
    ....
  74. ncbi PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5
    Mrudula Ganga
    Department of Biological Science, The University of Tulsa, Tulsa, Oklahoma 74104 3189, USA
    J Biol Chem 278:22437-45. 2003
    ..We report here that the atrial natriuretic factor (ANF) promoter is a target of PITX2...
  75. pmc Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy
    Bernardo V Alvarez
    Department of Physiology, Membrane Protein Research Group, University of Alberta, Edmonton, Canada T6G2H7
    J Physiol 579:127-45. 2007
    ..Phenylephrine (PE) increased cell size by 37 +/- 2% and increased expression of the hypertrophic marker, atrial natriuretic factor mRNA, twofold in cultured neonatal rat cardiomyocytes...
  76. pmc The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes
    K Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8397, Japan
    Mol Cell Biol 21:2085-97. 2001
    ..Our findings show that an NRSE-NRSF system plays a key role in the regulation of ANP gene expression by HDAC in ventricular myocytes and provide a new insight into the role of the NRSE-NRSF system outside the nervous system...
  77. ncbi Globular adiponectin inhibits angiotensin II-induced nuclear factor kappaB activation through AMP-activated protein kinase in cardiac hypertrophy
    Cheng Wang
    Key Laboratory of Molecular Cardiovascular Sciences, Department of Physiology and Pathophysiology, Peking University Health Science Center, Ministry of Education, Beijing, China
    J Cell Physiol 222:149-55. 2010
    ..When AMPK was inhibited, the suppressive effect of gAd on ANP mRNA expression was reduced. Our data indicate that gAd inhibits cardiac hypertrophic signaling through AMPK mediated suppression of NF-kappaB activation...
  78. ncbi Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin
    R Fassler
    Max Planck Institute of Biochemistry, Martinsried, Germany
    J Cell Sci 109:2989-99. 1996
    ..Thus, we conclude that interactions with the extracellular matrix via beta 1 integrin is necessary for differentiation and the maintenance of a specialized phenotype of cardiac muscle cells...
  79. pmc Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor
    L R Potter
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 18:2164-72. 1998
    ..We conclude that phosphorylation of the KHD is absolutely required for hormone-dependent activation of NPR-A...
  80. ncbi Cardiac natriuretic peptides for cardiac health
    Miriam T Rademaker
    Christchurch Cardioendocrine Research Group, Department of Medicine, The Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Clin Sci (Lond) 108:23-36. 2005
    ..The favourable biological properties of the natriuretic peptides have also led to their use as therapeutic agents...
  81. ncbi Increased blood pressure and loss of anp-induced natriuresis in mice lacking DARPP-32 gene
    A C Eklöf
    Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Hypertens 23:449-60. 2001
    ..The results confirm that DARPP-32 acts as a third messenger in the ANP signaling pathway in renal tissue and suggest an important role of DARPP-32 in the maintenance of normal blood pressure...
  82. ncbi A novel promoter variant of the natriuretic peptide clearance receptor gene is associated with lower atrial natriuretic peptide and higher blood pressure in obese hypertensives
    R Sarzani
    Institute of Clinical Medicine, University of Ancona, Italy
    J Hypertens 17:1301-5. 1999
    ..The objectives of the present study were to sequence the human 5'-flanking regulatory region of NPRC, to identify allelic variants and their frequencies, and to study the genotype/phenotype correlation in hypertensive patients...
  83. pmc Increased brain and atrial natriuretic peptides in patients with chronic right ventricular pressure overload: correlation between plasma neurohormones and right ventricular dysfunction
    I I Tulevski
    Department of Cardiology, Academic Medical Centre, Meibergdreef 9, 1100 DD Amsterdam, Netherlands
    Heart 86:27-30. 2001
    ..Monitoring changes in BNP and ANP may provide quantitative follow up of right ventricular dysfunction in these patients...
  84. ncbi Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure
    Osamu Tsukamoto
    Cardiovascular Division of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Coll Cardiol 53:2070-7. 2009
    ..We investigated the functional relationship between natriuretic peptides and adiponectin by performing both experimental and clinical studies...
  85. pmc Endothelial markers may link kidney function to cardiovascular events in type 2 diabetes
    Christina Maier
    Department of Endocrinology, Medical University Hospital Vienna, Vienna, Austria
    Diabetes Care 32:1890-5. 2009
    ..The aim of this study was to investigate the role of stable fragments of the precursors of adrenomedullin, endothelin-1, vasopressin, and atrial natriuretic peptide in progression of cardiovascular disease in patients with diabetes...
  86. ncbi Comparison of midregional pro-atrial and B-type natriuretic peptides in chronic heart failure: influencing factors, detection of left ventricular systolic dysfunction, and prediction of death
    Deddo Moertl
    Department of Cardiology, Medical University of Vienna, Vienna, Austria
    J Am Coll Cardiol 53:1783-90. 2009
    ....
  87. ncbi Atrial natriuretic peptide-C receptor-induced attenuation of adenylyl cyclase signaling activates phosphatidylinositol turnover in A10 vascular smooth muscle cells
    Rima Mouawad
    Department of Physiology, Faculty of Medicine, University of Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada, H3C 3J7
    Mol Pharmacol 65:917-24. 2004
    ....
  88. pmc The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression
    Y Lee
    Cardiovascular Research Center, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Mol Cell Biol 18:3120-9. 1998
    ..The promoter-enhancer region of the atrial natriuretic factor (ANF) contains several putative Csx binding sites and consensus GATA4 binding sites...
  89. pmc Atrial natriuretic peptide induces postprandial lipid oxidation in humans
    Andreas L Birkenfeld
    Experimental and Clinical Research Center, Charité and HELIOS Klinikum, Berlin, Germany
    Diabetes 57:3199-204. 2008
    ..We hypothesized that ANP increases postprandial free fatty acid (FFA) availability and energy expenditure while decreasing arterial blood pressure...
  90. ncbi Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides
    Toshio Nishikimi
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54, Shogoin Kawara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Cardiol 57:131-40. 2011
    ..In this review we discuss recent progress in our understanding of the biochemistry, molecular biology and clinical relevance of the natriuretic peptide system...
  91. ncbi Pressure overload-induced hypertrophy in transgenic mice selectively overexpressing AT2 receptors in ventricular myocytes
    Xinhua Yan
    Division of Cardiovascular Medicine, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Brighton, MA 02135, USA
    Am J Physiol Heart Circ Physiol 294:H1274-81. 2008
    ..iNOS was higher in AT2TG-AS than in NTG-AS mice but not significantly different. Our results indicate that AT2 receptor overexpression modified the pathological hypertrophic response to aortic banding in transgenic mice...
  92. ncbi Biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclases
    Johanne Tremblay
    Research Centre, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Mol Cell Biochem 230:31-47. 2002
    ..The structure and regulation of GC-B is similar to that of GC-A. This chapter reviews the structure and roles of GC-A and GC-B in blood pressure regulation and cardiac and renal pathophysiology...
  93. ncbi The predictive value of stable precursor fragments of vasoactive peptides in patients with chronic heart failure: data from the GISSI-heart failure (GISSI-HF) trial
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy
    Eur J Heart Fail 12:338-47. 2010
    ..We measured the plasma concentrations of four stable precursor fragments of neurohormonal systems in patients with chronic HF and evaluated their relationship with outcome...
  94. ncbi Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure
    Guido Boerrigter
    Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hypertension 49:1128-33. 2007
    ..These beneficial properties make direct soluble guanylate cyclase stimulation with BAY 58-2667 a promising new therapeutic strategy for cardiovascular diseases, such as heart failure...
  95. ncbi Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance
    Zaid Abassi
    Department of Vascular Surgery, Rambam Medical Center, P O Box 9602, 31096 Haifa, Israel
    Pharmacol Ther 102:223-41. 2004
    ..Thus, the goal of this article is to review the physiology and pathophysiology of natriuretic peptides and the potential use of their circulating levels for diagnosis and treatment of heart failure...
  96. ncbi Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes
    C Morisco
    Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Biol Chem 276:28586-97. 2001
    Inactivation of glycogen synthase kinase 3beta (GSK3beta) is critical for transcription of atrial natriuretic factor (ANF) by beta-adrenergic receptors in cardiac myocytes...
  97. ncbi Natriuretic peptides and genesis of asthma: an emerging paradigm?
    Shyam S Mohapatra
    Division of Allergy and Immunology JMC Airway Disease Research Center, University of South Florida, Tampa, FL 33612, USA
    J Allergy Clin Immunol 114:520-6. 2004
    ..Thus natriuretic peptides appear to play a pivotal role in the genesis and control of asthma, and they might provide an important target to modulate allergen-induced immune responses in allergic patients...
  98. ncbi Atrial natriuretic peptide has dose-dependent, autonomically mediated effects on atrial refractoriness and repolarization in anesthetized dogs
    Bruce S Stambler
    Department of Medicine, McGuire Veterans Affairs Medical Center, Medical College of Virginia, Richmond, Virginia, USA
    J Cardiovasc Electrophysiol 16:1341-7. 2005
    ....
  99. ncbi Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5
    Eiki Takimoto
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Circulation 115:2159-67. 2007
    ..The potential role of differential cGMP and protein kinase G stimulation by these 2 modulators was also studied...
  100. ncbi Spatiotemporal regulation of the two atrial natriuretic peptide receptors in testis
    Dieter Muller
    Institute for Hormone and Fertility Research, University of Hamburg, 22529 Hamburg, Germany
    Endocrinology 145:1392-401. 2004
    ....
  101. ncbi Vasopressin-dependent inhibition of the C-type natriuretic peptide receptor, NPR-B/GC-B, requires elevated intracellular calcium concentrations
    Sarah E Abbey
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:42423-30. 2002
    ..Together, these data reveal a dominant role for intracellular calcium in the reciprocal regulation of these two important vasoactive signaling systems...

Research Grants63

  1. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..release (vanillyl mandelic acid, metanephrines and normetanephrine), and in plasma levels of atrial natriuretic factor, a marker of atrial stretch...
  2. Molecular control of differential peptide transmitter exocytosis.
    COREY B SMITH; Fiscal Year: 2013
    ..enkephalin), increased cardiac output (elevated catecholamines), blood flow to skeletal muscle (atrial natriuretic factor, Neuropeptide Y) and blood glucose (pancreastatin)...
  3. INHIBITORY LEFT ATRIAL INFLUENCES ON THE BAROREFLEX
    David Ramsay; Fiscal Year: 1991
    ..junctional region will be used to assess the effects of increasing afferent discharge without release of atrial natriuretic factor (ANF), and compared with inflation of a balloon placed at the mitral valve orifice which increases ..
  4. RENAL FUNCTION AND BLOOD PRESSURE CONTROL IN PREGNANCY
    Edmond Quillen; Fiscal Year: 2000
    ..Studies are proposed that will further define mechanisms responsible for the control of atrial natriuretic factor (ANF) secretion, the actions of ANF on kidney, the actions of nitric oxide (NO) on the kidney, and both ..
  5. LUNG VASCULAR EFFECTS OF HIGH FREQUENCY VENTILATION
    MUKUL BANERJEE; Fiscal Year: 1992
    ..The working hypothesis is that vasoactive substances, eicosanoids and atrial natriuretic factor (ANF) are released during substances can influence cardiac output, pulmonary and systemic vascular ..
  6. CIRCULATORY CONTROL IN CHRONIC HYPOTENSIVE STATES
    ROSE ROBERTSON; Fiscal Year: 1990
    ..assess intravascular volume during controlled sodium intake and the responses of renin, angiotension and atrial natriuretic factor to volume manipulation...
  7. REGULATION OF CYCLIC GMP DEPENDENT PROTEIN KINASE
    MICHAEL UHLER; Fiscal Year: 1999
    ..second messenger, cyclic GMP (cGMP) is believed to mediate the intracellular effects of nitric oxide and atrial natriuretic factor (ANF) on the relaxation of smooth muscle...
  8. BIOLOGY OF ATRIAL NATRIURETIC FACTOR AND ITS RECEPTORS
    Thomas Maack; Fiscal Year: 2000
    The long-term objective of the research is to understand the functions of atrial natriuretic factor (ANF), and of its two main receptors...
  9. Trypanosoma cruzi-elicited cardiac hypertrophy
    Christine Petersen; Fiscal Year: 2004
    ..cruzi results in increased expression of a classical marker for cardiac hypertrophy, atrial natriuretic factor (ANF), and causes an increase in cell size...
  10. VOLUME REGULATION IN DIABETES--INTRARENAL MECHANISMS
    Kaushik Patel; Fiscal Year: 2002
    ..Furthermore, preliminary data suggest that influence of nitric oxide (NO), atrial natriuretic factor (ANF) and renal nerves on renal excretory function are altered in diabetic rats...
  11. SPECIFIC KALLIKREIN INHIBITORS FOR CARDIOVASCULAR STUDY
    James Burton; Fiscal Year: 1991
    ..In vivo testing of the kallikrein inhibitors will focus on the effect of the compounds on blood pressure, regional distribution of blood flow and changes in various kidney parameters...
  12. RENAL FUNCTION IN PROTEIN DEFICIENCY
    MANUEL MARTINEZ MALDONADO; Fiscal Year: 1990
    ..We propose experiments to systematically examine the role of renin, angiotensin prostaglandins, NE, atrial natriuretic factor (ANF), antidiuretic hormone (ADH), and PTH on systemic and renal hemodynamics...
  13. CONTROL OF ANF PRODUCTION IN HYPERTENSION
    BALVIN CHUA; Fiscal Year: 1990
    Mammalian cardiac atria contain a group of biologically active peptides called atrial natriuretic factor (ANF)...
  14. EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    David Gardner; Fiscal Year: 2002
    ..abstract_text> ..
  15. SIGNALS OF OXIDANT INDUCED CARDIOMYOCYTE HYPERTROPHY
    Qin Chen; Fiscal Year: 1999
    ..The expression of the atrial natriuretic factor, beta-myosin heavy chain, skeletal alpha-actin, alpha-myosin heavy chain, ventricular-specific myosin ..
  16. BLOOD PRESSURE & RENAL FUNCTION IN HYPERINSULINEMIA
    John Hall; Fiscal Year: 1991
    ..in activity of the renin-angiotensin system (RAS), aldosterone, the sympathetic nervous system, and atrial natriuretic factor (ANF) in modulating insulin-sodium-blood pressure interrelationships...
  17. ENDOCRINE CONTROL OF FETAL CARDIOVASCULAR DYNAMICS
    CECILIA CHEUNG; Fiscal Year: 2000
    In the fetus the cardiac hormone atrial natriuretic factor (ANF) is important in the control of cardiovascular function and fluid balance under normal and hypoxic conditions...
  18. NEUROHUMORAL CONTROL OF BLOOD VOLUME
    Thomas Peterson; Fiscal Year: 1992
    ..The factors to be investigated include renal nerves, cardiac nerves and atrial natriuretic factor (ANF). Thus the objective encompasses both neural and humoral mechanisms...
  19. NEURAL CONTROL OF ANF IN PULMONARY HYPERTENSION
    ALEX BAERTSCHI; Fiscal Year: 1993
    There is a rapidly increasing basic and clinical interest in a better understanding of atrial natriuretic factor (ANF) secretion in pulmonary hypertension...
  20. EFFECT OF ATRIAL NATRIURETIC FACTOR IN HUMANS
    Thomas Ebert; Fiscal Year: 1992
    ..experimental animals over the past 6 years, the mechanism(s) of the cardiovascular, and renal effects of atrial natriuretic factor (ANF) remain unclear...
  21. CONTROL OF RENAL FUNCTION BY INTRARENAL ANGIOTENSIN
    Robert Carey; Fiscal Year: 1991
    ..The interactions of angiotensin II with atrial natriuretic factor and dopamine within the kidney will be studied...
  22. CONTROLLED RELEASE OF ATRIAL NATRIURETIC FACTOR
    Maria Rupnick; Fiscal Year: 2001
    ..End of Abstract) ..
  23. DESIGN OF SUICIDE INHIBITORS FR ENKEPHALINASE
    ODILE SAID NEJAD; Fiscal Year: 1991
    ..implicated in the degradation of the opiate peptides, Met-enkephalin and Leu-enkephalin, and also of atrial natriuretic factor (ANF)...
  24. CONVERTING ENZYME INHIBITION & CARDIOVASCULAR REACTIVITY
    Joel Dimsdale; Fiscal Year: 1991
    ..blood pressure, heart rate, plasma and urinary catecholamines, renin, aldosterone, angiotensin II, atrial natriuretic factor, urinary sodium, and the slope of the dose response curve relating infused norepinephrine to blood ..
  25. STRESS, SODIUM, AND BLOOD PRESSURE REGULATION
    Thomas Pickering; Fiscal Year: 1990
    ..Blood and urine samples will be taken for measures related to sodium balance (plasma renin, atrial natriuretic factor, urine aldosterone, and electrolytes) and stress (blood lipids and cortisol, and urine catecholamines ..
  26. GROWTH AND DIFFERENTIATION OF HUMAN CARDIOBLASTS
    DONALD KOHTZ; Fiscal Year: 1992
    ..These will include probes for contractile proteins, developmental proteins (proto-oncogenes), and Atrial Natriuretic Factor. Experiments are also proposed to observe the effects of co-cultured neuronal cells on the ..
  27. CARDIAC PEPTIDES IN THE CONTROL OF BLOOD VOLUME
    John Dietz; Fiscal Year: 1993
    ..the atria contain a potent natriuretic and blood pressure lowering substance which has been termed the atrial natriuretic factor (ANF)...
  28. ATRIAL NATRIURETIC FACTOR
    Bruce Benjamin; Fiscal Year: 1992
    Recent investigations have provided considerable evidence showing that 1) atrial natriuretic factor (ANF) is secreted by the heart in response to atrial stretch and 2) administration of ANF affects renal salt and water excretion, blood ..
  29. DEVELOPMENT AND DIVERSIFICATION OF CARDIAC MYOCYTES
    Jeffrey Miller; Fiscal Year: 1992
    ..b>Atrial natriuretic factor (ANF) is secreted predominately from atrial myocytes, and distinct patterns of myosin heavy chain (MHC) ..
  30. PRIMATE ENDOCRINE REGULATION IN THE PERINATAL PERIOD
    Robert Jaffe; Fiscal Year: 1992
    ..In addition, the binding of atrial natriuretic factor to the fetal adrenal and its effect on adrenal steroidogenesis will be determined...
  31. HORMONAL CONTROL OF RENAL FUNCTION
    John Hall; Fiscal Year: 1992
    ..cycles associated with development of renal failure and malignant hypertension, and (2) the role of atrial natriuretic factor (ANF) in long-term control of renal function and arterial pressure in normotensive and hypertensive ..
  32. Glucose Regulated Gene Expression in the Heart
    Martin Young; Fiscal Year: 2002
    ..factors, resulting in a uniform genomic response, including the re-expression of fetal genes (atrial natriuretic factor, myosin heavy chain beta (MHCbeta) and skeletal alpha actin), and the selective repression of adult ..
  33. REGULATION OF CYCLIC NUCLEOTIDE FORMATION AND ACTION
    Ferid Murad; Fiscal Year: 1991
    ..The effects of atrial natriuretic factor and E...
  34. REGULATION OF RENAL CIRCULATION
    DONALD MARSH; Fiscal Year: 1990
    ..prostaglandins modulate the action of angiotensin II on juxtamedullary efferent arterioles, and to test whether atrial natriuretic factor affects vasa recta flow independently on an effect on reabsorption from medullary collecting ducts.
  35. Regulation of aquaporin-2 trafficking in collecting duct
    Kay Pong Yip; Fiscal Year: 2006
    ..Physiological dose of atrial natriuretic factor (ANF) inhibits AVP stimulated Pf and [Ca2+]i oscillations...
  36. PACING INDUCED GENE EXPRESSION IN CARDIAC MYOCYTES
    Patrick McDonough; Fiscal Year: 1999
    b>Atrial natriuretic factor (ANF) is a potent endogenous anti-hypertensive hormone derived from cardiac myocytes...
  37. ENDOCRINE REGULATION OF CARDIAC HORMONE EXPRESSION
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 1999
    ..The regulation of blood pressure and volume is critically dependent on a number of hormones including ANF (atrial natriuretic factor) and BNP (brain natriuretic peptide)...
  38. HYPERTENSION AND ANF EXPRESSION IN TRANSGENIC MICE
    Loren Field; Fiscal Year: 1991
    ..In this study, the relationship between aberrant Atrial Natriuretic Factor (ANF) expression and hypertension will be investigated...
  39. CHARACTERIZATION OF FERRITIN FROM HORSE HEART AND SERUM
    CORINNE CAMPBELL; Fiscal Year: 1992
    ..of Ft in heart is destined for secretion, perhaps by a mechanism similar to that for the secretion of atrial natriuretic factor. Taken together these data suggest that heart is the site of synthesis of serum Ft...
  40. SECRETION AND RENAL EFFECTS OF CARDIAC PEPTIDES
    John Dietz; Fiscal Year: 2001
    ..Recent evidence suggests that several peptides derived from the N-terminal portion of the atrial natriuretic factor (ANF) prohormone also play an important role in regulating kidney function and arterial blood pressure...
  41. DEVELOPMENT OF STABLE CARDIAC CELL LINES
    Christine Seidman; Fiscal Year: 1992
    ..Further, recent advances in our analysis of the gene encoding the cardiac-specific peptide, atrial natriuretic factor (ANF), provide a new set of tools that permit activation of particular genes exclusively in the atria ..
  42. Genetic Predictors of Outcome in Acute MI
    Marc Sabatine; Fiscal Year: 2005
    ..Genomic control will be employed to detect and control for population stratification. Interaction terms will be incorporated into regression models to explore gene-environment and pharmacogenomic interactions. ..
  43. Nucleoside analogs, mitochondria and AIDS cardiomyopathy
    William Lewis; Fiscal Year: 2006
    ..AIM 2: to define CM from HAART microscopically and ultrastructurally using morphometric methods. AIM 3: to define cardiac performance in CM from HAART echocardiographically and using Langendorff preparations. ..
  44. NEW APPROACH TO ENDOTHELIAL CLEFT STRUCTURE
    Fitz Roy E Curry; Fiscal Year: 2010
    ..Our experiments evaluate the common mechanical properties of the endothelial glycocalyx that modulate water, solute, leukocyte, and red cell fluxes at the endothelial cell surface. ..
  45. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2009
    ..HYPOTHESIS 4: mtDNA depletion (from any above) causes or results from oxidative stress. Antioxidants ameliorate oxidative stress from NRTIs by decreasing oxidation of mtDNA. ..
  46. Hepatic mitochondrial oxidative stress, AIDS and alcohol
    William Lewis; Fiscal Year: 2005
    ..Biochemical, molecular and pathological changes (above) are ameliorated. This serves as a "proof of principle". ..
  47. MAGNETIC RESONANCE CARDIAC C13FLUX AND METABOLIC RATE
    E Lewandowski; Fiscal Year: 2001
    ..The long range objective is the ultimate use of C13 NMR to assess the activity and expression of these mitochondrial proteins that regulate metabolic flux in intact and in vivo organs during development and disease. ..