somatostatin

Summary

Summary: A polypeptide hormone produced in the HYPOTHALAMUS, and other tissues and organs. It inhibits the release of growth hormone (SOMATOTROPIN), and also modulates important physiological functions of the kidney, pancreas, and gastrointestinal tract. Somatostatin receptors are widely expressed throughout the body. Somatostatin also acts as a neurotransmitter in the central and peripheral nervous systems.

Top Publications

  1. ncbi Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse
    Nobuaki Tamamaki
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Comp Neurol 467:60-79. 2003
  2. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
  3. ncbi Somatostatin and its receptor family
    Y C Patel
    Department of Medicine, Royal Victoria Hospital, Montreal, Quebec, H3A 1A1, Canada
    Front Neuroendocrinol 20:157-98. 1999
  4. ncbi The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
    B Sosa-Pineda
    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Nature 386:399-402. 1997
  5. ncbi Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
    G A Gonzalez
    Clayton Foundation Laboratory for Peptide Biology, Salk Institute, La Jolla, California 92037
    Cell 59:675-80. 1989
  6. ncbi Cohort study of somatostatin-based radiopeptide therapy with [(90)Y-DOTA]-TOC versus [(90)Y-DOTA]-TOC plus [(177)Lu-DOTA]-TOC in neuroendocrine cancers
    Linda Villard
    University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    J Clin Oncol 30:1100-6. 2012
  7. ncbi Clinical review: Current scientific rationale for the use of somatostatin analogs and mTOR inhibitors in neuroendocrine tumor therapy
    Corinne Bousquet
    Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 1037, Cancer Research Center of Toulouse, 1 avenue Jean Poulhes, BP 84225, 31432 Toulouse Cedex 4, France
    J Clin Endocrinol Metab 97:727-37. 2012
  8. pmc Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4
    Han Xu
    Department of Physiology and Neuroscience, Smilow Neuroscience Program, NYU School of Medicine, New York, NY 10016, USA
    Neuron 77:155-67. 2013
  9. pmc Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex
    Erika E Fanselow
    Department of Neurobiology, University of Pittsburgh School of Medicine, W1458 Thomas E Starzl Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    J Neurophysiol 100:2640-52. 2008
  10. ncbi Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanisms
    Simona Grozinsky-Glasberg
    Barts and the London School of Medicine, Centre for Endocrinology, University of London, London EC1M 6BQ, UK
    Endocr Relat Cancer 15:701-20. 2008

Detail Information

Publications352 found, 100 shown here

  1. ncbi Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse
    Nobuaki Tamamaki
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Comp Neurol 467:60-79. 2003
    ..the knock-in mice to investigate the colocalization of GFP with NeuN, calretinin (CR), parvalbumin (PV), and somatostatin (SS) in the frontal motor cortex...
  2. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
    ..Thus, ngn3 is required for the specification of a common precursor for the four pancreatic endocrine cell types...
  3. ncbi Somatostatin and its receptor family
    Y C Patel
    Department of Medicine, Royal Victoria Hospital, Montreal, Quebec, H3A 1A1, Canada
    Front Neuroendocrinol 20:157-98. 1999
    b>Somatostatin (SST), a regulatory peptide, is produced by neuroendocrine, inflammatory, and immune cells in response to ions, nutrients, neuropeptides, neurotransmitters, thyroid and steroid hormones, growth factors, and cytokines...
  4. ncbi The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
    B Sosa-Pineda
    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Nature 386:399-402. 1997
    ..four endocrine cell types found in the adult pancreas-(alpha, beta, delta and PP-synthesize glucagon, insulin, somatostatin and pancreatic polypeptide, respectively...
  5. ncbi Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
    G A Gonzalez
    Clayton Foundation Laboratory for Peptide Biology, Salk Institute, La Jolla, California 92037
    Cell 59:675-80. 1989
    ....
  6. ncbi Cohort study of somatostatin-based radiopeptide therapy with [(90)Y-DOTA]-TOC versus [(90)Y-DOTA]-TOC plus [(177)Lu-DOTA]-TOC in neuroendocrine cancers
    Linda Villard
    University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    J Clin Oncol 30:1100-6. 2012
    Radiopeptide therapy is commonly performed with a single radioisotope. We aimed to compare the effectiveness of somatostatin-based radiopeptide therapy with a single versus a combination of radioisotopes.
  7. ncbi Clinical review: Current scientific rationale for the use of somatostatin analogs and mTOR inhibitors in neuroendocrine tumor therapy
    Corinne Bousquet
    Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 1037, Cancer Research Center of Toulouse, 1 avenue Jean Poulhes, BP 84225, 31432 Toulouse Cedex 4, France
    J Clin Endocrinol Metab 97:727-37. 2012
    Among the innovative molecules used to manage neuroendocrine tumors, there is growing interest in combining the somatostatin analogs octreotide or pasireotide (SOM230) and everolimus (RAD001), an inhibitor that targets the protein kinase ..
  8. pmc Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4
    Han Xu
    Department of Physiology and Neuroscience, Smilow Neuroscience Program, NYU School of Medicine, New York, NY 10016, USA
    Neuron 77:155-67. 2013
    ..In contrast to supra- and infragranular layers, where most somatostatin-expressing (SOM) INs are layer 1-targeting Martinotti cells, the axons of SOM INs in layer 4 of somatosensory ..
  9. pmc Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex
    Erika E Fanselow
    Department of Neurobiology, University of Pittsburgh School of Medicine, W1458 Thomas E Starzl Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    J Neurophysiol 100:2640-52. 2008
    ..of inhibitory interneurons, identified using mice that express green fluorescent protein (GFP) in a subset of somatostatin-expressing inhibitory cells ("GFP-expressing inhibitory neuron" [GIN] cells)...
  10. ncbi Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanisms
    Simona Grozinsky-Glasberg
    Barts and the London School of Medicine, Centre for Endocrinology, University of London, London EC1M 6BQ, UK
    Endocr Relat Cancer 15:701-20. 2008
    ..The development of somatostatin analogues (SSA) as important diagnostic and treatment tools has revolutionised the clinical management of ..
  11. pmc Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons
    Jay R Gibson
    Department of Neuroscience and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Neurosci 29:13883-97. 2009
    ..synapses between excitatory neurons and two subtypes of inhibitory interneurons, namely, fast-spiking and somatostatin-positive interneurons...
  12. ncbi Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial
    M Boscaro
    Division of Endocrinology, Polytechnic University of Marche, 60126 Ancona, Italy
    J Clin Endocrinol Metab 94:115-22. 2009
    ..There is currently no medical therapy for Cushing's disease that targets the pituitary adenoma. Availability of such a medical therapy would be a valuable therapeutic option for the management of this disorder...
  13. pmc Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice
    Yunyong Ma
    Department of Neurobiology and Anatomy, West Virginia University, Morgantown, West Virginia 26506, USA
    J Neurosci 26:5069-82. 2006
    ..In two of these lines, named X94 and X98, GFP expression in the barrel cortex was restricted to subsets of somatostatin-containing (SOM+) GABAergic interneurons, similar to the previously reported "GIN" line (Oliva et al...
  14. ncbi Somatostatin-receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors
    Dik J Kwekkeboom
    Department of Nuclear Medicine, Erasmus Medical Center, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Endocr Relat Cancer 17:R53-73. 2010
    b>Somatostatin receptor imaging (SRI) with [(111)In-DTPA(0)]octreotide has proven its role in the diagnosis and staging of gastroenteropancreatic neuroendocrine tumors (GEPNETs)...
  15. pmc Spatial and temporal bias in the mitotic origins of somatostatin- and parvalbumin-expressing interneuron subgroups and the chandelier subtype in the medial ganglionic eminence
    Melis Inan
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cereb Cortex 22:820-7. 2012
    ..Previous reports identified a spatial bias for the origins of parvalbumin (PV)- and somatostatin (SST)-expressing interneuron subgroups within the medial ganglionic eminence (MGE)...
  16. ncbi SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile
    C Bruns
    Novartis Pharma AG, Research Transplantation, WSJ 386, CH 4002 Basel, Switzerland
    Eur J Endocrinol 146:707-16. 2002
    ..metabolically stable somatotropin release inhibiting factor (SRIF) analog with a more universal binding profile similar to that of natural somatostatin, resulting in improved pharmacological properties and hence new therapeutic uses.
  17. ncbi Randomized controlled clinical trial of a combination of somatostatin analog and dexamethasone plus zoledronate vs. zoledronate in patients with androgen ablation-refractory prostate cancer
    Constantine S Mitsiades
    Department of Experimental Physiology, Medical School, University of Athens, Goudi Athens, Attiki 115 27, Greece
    Anticancer Res 26:3693-700. 2006
    As previously shown, the combination of standard androgen ablation therapy with somatostatin analog and dexamethasone in metastatic androgen ablation-refractory (stage D3) prostate cancer (PrCa) patients has a favorable profile of side-..
  18. ncbi The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding
    M A Schumacher
    Department of Biochemistry and Molecular Biology and the Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Biol Chem 275:35242-7. 2000
    ..CREB bZIP (residues 283-341) bound to a 21-base pair deoxynucleotide that encompasses the canonical 8-base pair somatostatin cAMP response element (SSCRE)...
  19. ncbi Peptide Receptor Radionuclide Therapy with radiolabelled somatostatin analogues in patients with somatostatin receptor positive tumours
    Martijn van Essen
    Department of Nuclear Medicine, Erasmus MC, s Gravendijkwal 230, Rotterdam, CE, The Netherlands
    Acta Oncol 46:723-34. 2007
    Peptide Receptor Radionuclide Therapy (PRRT) with radiolabelled somatostatin analogues is a promising treatment option for patients with inoperable or metastasised neuroendocrine tumours...
  20. pmc Immunochemical characterization of inhibitory mouse cortical neurons: three chemically distinct classes of inhibitory cells
    Xiangmin Xu
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 518:389-404. 2010
    ..In rat cortex, past research has shown that parvalbumin (PV), somatostatin (SOM), calretinin (CR), and cholecystokinin (CCK) label four distinct chemical classes of GABAergic ..
  21. ncbi A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly
    Robert D Murray
    Department of Endocrinology, Leeds Teaching Hospitals National Health Service Trust, Leeds, UK
    J Clin Endocrinol Metab 93:2957-68. 2008
    Short and long-acting somatostatin (SRIF) analogs are approved for clinical use in acromegaly...
  22. ncbi Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
    S Gremlich
    Institute of Pharmacology and Toxicology, University of Lausanne, 27, Rue du Bugnon, CH 1005 Lausanne, Switzerland
    J Biol Chem 272:30261-9. 1997
    ..is required for embryonic development of the pancreas and transactivates the Glut2, glucokinase, insulin, and somatostatin genes...
  23. ncbi Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis
    Anne Katja Imhof
    University Hospital and Friedrich Schiller University Jena, Jena, Germany
    Arthritis Rheum 63:2352-62. 2011
    Clinical and preclinical evidence suggests that somatostatin exhibits potent antiinflammatory and antinociceptive properties. However, it is not known which of the 5 somatostatin receptor subtypes (SSTRs 1-5) is involved in these actions...
  24. ncbi Somatostatin/somatostatin receptor signalling: phosphotyrosine phosphatases
    Tullio Florio
    Department of Oncology, Biology and Genetics, University of Genova, Genova, Italy
    Mol Cell Endocrinol 286:40-8. 2008
    Activation of phosphotyrosine phosphatases (PTPs) by somatostatin receptor (SSTR) represents one of the main intracellular mechanisms involved in the antiproliferative effect of somatostatin (SST) and analogues...
  25. ncbi Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities
    T Florio
    Farmacologia e Neuroscienze, Istituto Nazionale per la Ricerca sul Cancro, Universita di Genova, 16132 Genova, Italy
    Endocrinology 144:1574-84. 2003
    b>Somatostatin was reported to inhibit Kaposi's sarcoma (KS) cell (KS-Imm) xenografts through an antiangiogenic activity...
  26. ncbi Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
    J de Heer
    Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200, Copenhagen N, Denmark
    Diabetologia 51:2263-70. 2008
    ..We examined whether the islet hormone somatostatin, which strongly inhibits glucagon secretion, is involved in this divergent behaviour.
  27. ncbi Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro
    Sarah Lesche
    Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Clin Endocrinol Metab 94:654-61. 2009
    The clinically used somatostatin analogs, octreotide and lanreotide, act primarily by binding to somatostatin receptor 2 (sst2)...
  28. ncbi Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: response to amitriptyline treatment
    I Heuser
    Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
    Depress Anxiety 8:71-9. 1998
    ..HPA]-system-regulating neuropeptides (corticotropin-releasing hormone [CRH], vasopressin, somatostatin) was studied in a group of depressed elderly patients and controls...
  29. pmc Satb1 is an activity-modulated transcription factor required for the terminal differentiation and connectivity of medial ganglionic eminence-derived cortical interneurons
    Jennie Close
    New York University Neuroscience Institute and the Departments of Physiology and Neuroscience, NYU Langone Medical Center, New York, New York 10016, USA
    J Neurosci 32:17690-705. 2012
    ..identified transcription factors crucial for the specification and migration of parvalbumin (PV)-expressing and somatostatin (SST)-expressing interneurons, the intrinsic factors required for the terminal differentiation, connectivity, ..
  30. ncbi Remission of Merkel cell tumor after somatostatin analog treatment
    M Fakiha
    Department of Plastic and Maxillofacial Surgery, CHU Grenoble Hospital, Grenoble, France
    J Cancer Res Ther 6:382-4. 2010
    ..treated one patient presenting with a disseminated non-operable Merkel cell carcinoma (MCC) by lanreotide (somatostatin analog), with a complete remission of the disease and a follow up of 17 months...
  31. ncbi Somatostatin receptors in gastroentero-pancreatic neuroendocrine tumours
    W W de Herder
    Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Endocr Relat Cancer 10:451-8. 2003
    Five somatostatin receptor (sst) subtype genes, sst(1), sst(2), sst(3), sst(4) and sst(5), have been cloned and characterised. The five sst subtypes all bind natural somatostatin-14 and somatostatin-28 with high affinity...
  32. ncbi Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2
    Federica Barbieri
    Laboratory pf Pharmacology, Department of Oncology, Biology, and Genetics, University of Genova, Viale Benedetto XV, 2, 16132 Genova, Italy
    Endocrinology 149:4736-46. 2008
    b>Somatostatin inhibits cell proliferation through the activation of five receptors (SSTR1-5) expressed in normal and cancer cells...
  33. pmc Alterations in somatostatin mRNA expression in the dorsolateral prefrontal cortex of subjects with schizophrenia or schizoaffective disorder
    Harvey M Morris
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cereb Cortex 18:1575-87. 2008
    ..prefrontal cortex (DLPFC) in schizophrenia include reduced expression of the messenger RNA (mRNA) for somatostatin (SST), a neuropeptide present in a subpopulation of gamma-aminobutyric acid (GABA) neurons...
  34. ncbi DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours
    U Plockinger
    Interdisziplinäres Stoffwechsel Centrum, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 166:223-34. 2012
    b>Somatostatin analogues (SSA) reduce autonomous GH secretion by activating somatostatin receptors (sst) 2 and 5 in 50-60% of acromegalic patients. However, by inhibiting insulin secretion these SSA reduce glucose tolerance...
  35. pmc Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin
    Jose Cordoba-Chacon
    Department of Cell Biology, University of Cordoba, Campus de Rabanales, Cordoba, Spain
    Endocrinology 152:4800-12. 2011
    Cortistatin (CST) and somatostatin (SST) evolve from a common ancestral gene and share remarkable structural, pharmacological, and functional homologies...
  36. ncbi Somatostatin suppresses ghrelin secretion from the rat stomach
    Mitsushi Shimada
    Department of Internal Medicine, Oita Medical University, Oita 879 5593, Japan
    Biochem Biophys Res Commun 302:520-5. 2003
    ..b>Somatostatin, a peptide produced in the gastric oxyntic mucosa, is known to suppress secretion of several gastrointestinal ..
  37. pmc Reduced somatostatin in subgenual anterior cingulate cortex in major depression
    Adam Tripp
    Department of Psychiatry, University of Pittsburgh, PA 15312, USA
    Neurobiol Dis 42:116-24. 2011
    ..Underlying mechanisms may include altered GABAergic function. Expression of somatostatin (SST), an inhibitory neuropeptide localized to a subset of GABA neurons, has been shown to be lower in the ..
  38. ncbi Pharmacological profile of somatostatin and cortistatin receptors
    Sandra Siehler
    Neuroscience Research, Novartis Institutes for BioMedical Research Basel, Basel, Switzerland
    Mol Cell Endocrinol 286:26-34. 2008
    b>Somatostatin (SRIF) and cortistatin (CST) are two endogenous peptides with high sequence similarities that act as hormones/neurotransmitters both in the CNS and the periphery; their genes although distinct result from gene duplication...
  39. ncbi Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives
    W A Breeman
    Department of Nuclear Medicine, Erasmus Medical Centre Rotterdam, The Netherlands
    Eur J Nucl Med 28:1421-9. 2001
    In vivo somatostatin receptor-mediated scintigraphy has proven to be a valuable method for the visualisation of neuroendocrine tumours and their metastases...
  40. pmc Epigenetic silencing of somatostatin in gastric cancer
    Kaya Jackson
    Department of Surgery, Meharry Medical College, Nashville, Tennessee 37208, USA
    Dig Dis Sci 56:125-30. 2011
    b>Somatostatin (SST), a primary inhibitor of gastrin-stimulated gastric acid secretion, has potent antitumor and anti-secretory activity in several human cancers.
  41. ncbi PET of somatostatin receptor-positive tumors using 64Cu- and 68Ga-somatostatin antagonists: the chelate makes the difference
    Melpomeni Fani
    Division of Radiological Chemistry, University Hospital Basel, Basel, Switzerland
    J Nucl Med 52:1110-8. 2011
    b>Somatostatin-based radiolabeled peptides have been successfully introduced into the clinic for targeted imaging and radionuclide therapy of somatostatin receptor (sst)-positive tumors, especially of subtype 2 (sst2)...
  42. pmc Somatostatin signaling in neuronal cilia is critical for object recognition memory
    Emily B Einstein
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Neurosci 30:4306-14. 2010
    ..Cilia express a complement of proteins distinct from other neuronal compartments, one of which is the somatostatin receptor subtype SST(3). We show here that SST(3) is critical for object recognition memory in mice...
  43. pmc Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function
    Astrid C Hauge-Evans
    Beta Cell Development and Function Group, Division of Reproduction and Endocrinology, King s College London, London, UK
    Diabetes 58:403-11. 2009
    b>Somatostatin (SST) is secreted by islet delta-cells and by extraislet neuroendocrine cells...
  44. ncbi Postsynaptic targets of somatostatin-containing interneurons in the rat basolateral amygdala
    Jay F Muller
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
    J Comp Neurol 500:513-29. 2007
    ..interneurons, very little is known about the synaptic outputs of the interneuronal subpopulation that expresses somatostatin (SOM)...
  45. ncbi Mortality in acromegaly: a metaanalysis
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 93:61-7. 2008
    ..For this reason, it is not formally established whether mortality in acromegaly is different from the general population...
  46. ncbi Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells
    Katharina Timper
    Department of Research, University Hospital, Basel, Switzerland
    Biochem Biophys Res Commun 341:1135-40. 2006
    ..Using quantitative PCR a down-regulation of ABCG2 and up-regulation of pancreatic developmental transcription factors Isl-1, Ipf-1, and Ngn3 were observed together with induction of the islet hormones insulin, glucagon, and somatostatin.
  47. ncbi ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: peptide receptor radionuclide therapy with radiolabeled somatostatin analogs
    Dik J Kwekkeboom
    Department of Nuclear Medicine, Erasmus University Medical Center, NL 3015 Rotterdam, The Netherlands
    Neuroendocrinology 90:220-6. 2009
    ..It is not this guideline's aim to give specific recommendations on the use of specific radiolabeled somatostatin analogs for PRRT because different analogs are being used, and their availability depends on national law and ..
  48. ncbi Pasireotide (SOM230) demonstrates efficacy and safety in patients with acromegaly: a randomized, multicenter, phase II trial
    S Petersenn
    Division of Endocrinology, Medical Center, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    J Clin Endocrinol Metab 95:2781-9. 2010
    Pasireotide (SOM230) is a novel multireceptor ligand somatostatin analog with affinity for somatostatin receptor subtypes sst(1-3) and sst(5)...
  49. ncbi Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity
    M Rocheville
    Fraser Laboratories, Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    Science 288:154-7. 2000
    b>Somatostatin and dopamine are two major neurotransmitter systems that share a number of structural and functional characteristics...
  50. ncbi Clinical review: The antitumoral effects of somatostatin analog therapy in acromegaly
    John S Bevan
    Department of Endocrinology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland, United Kingdom
    J Clin Endocrinol Metab 90:1856-63. 2005
    b>Somatostatin analogs are the mainstay of medical therapy for acromegaly. Suppression of GH hypersecretion, lowering of IGF-I production, and control of symptoms are established benefits of therapy...
  51. ncbi A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly
    Shlomo Melmed
    Department of Medicine, Cedars Sinai Research Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 90:4405-10. 2005
    b>Somatostatin analogs have been successfully used to treat patients with GH-secreting pituitary adenomas because they are safe, effective, and usually well tolerated...
  52. ncbi Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose
    S Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Wash 98108, USA
    Arch Gen Psychiatry 56:1135-40. 1999
    ..We address this question by examining memory and counterregulatory hormone response during hyperglycemia when endogenous insulin was suppressed by concomitant infusion of the somatostatin analogue octreotide (Sandostatin).
  53. pmc Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses
    Wen Pei Ma
    Zilkha Neurogenetic Institute, Departments of Cell and Neurobiology and Biophysics and Physiology, and Graduate Programs, University of Southern California, Los Angeles, California 90089, and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724
    J Neurosci 30:14371-9. 2010
    b>Somatostatin-expressing inhibitory (SOM) neurons in the sensory cortex consist mostly of Martinotti cells, which project ascending axons to layer 1...
  54. ncbi The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
    ..alpha- and beta-cells occurs in the endocrine pancreas, concomitantly with a virtually exclusive generation of somatostatin-producing cells...
  55. ncbi Pasireotide (SOM230): development, mechanism of action and potential applications
    Herbert A Schmid
    Novartis Institutes for BioMedical Research, Oncology Research, Novartis Pharma AG, Basel, Switzerland
    Mol Cell Endocrinol 286:69-74. 2008
    Pasireotide (SOM230) is a multi-receptor ligand somatostatin analogue with high binding affinity for somatostatin receptor subtypes sst(1,2,3) and sst(5)...
  56. pmc The roles of somatostatin-expressing (GIN) and fast-spiking inhibitory interneurons in UP-DOWN states of mouse neocortex
    Erika E Fanselow
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    J Neurophysiol 104:596-606. 2010
    ..RS) excitatory cells and two types of inhibitory neurons, the fast-spiking (FS) neurons and GFP- (and somatostatin-) expressing inhibitory neurons (GIN), in layer 2/3 of slices from mouse somatosensory neocortex...
  57. ncbi Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease
    Blanca Ramos
    Department Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain
    Neurobiol Aging 27:1658-72. 2006
    ..mRNA markers tested (including GABAergic, glutamatergic and cholinergic markers), only the expression of somatostatin (SOM) and NPY neuropeptides (O-LM and HIPP markers) displayed a significant decrease...
  58. ncbi Opportunities in somatostatin research: biological, chemical and therapeutic aspects
    Gisbert Weckbecker
    Transplantation and Immunology, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Nat Rev Drug Discov 2:999-1017. 2003
  59. ncbi Comparison of somatostatin analog and meta-iodobenzylguanidine radionuclides in the diagnosis and localization of advanced neuroendocrine tumors
    G Kaltsas
    Department of Endocrinology, St. Bartholomew's Hospital, London, United Kingdom EC1A 7BE
    J Clin Endocrinol Metab 86:895-902. 2001
    ..These data have implications not only for staging such tumors, but also for identifying patients who might benefit from treatment using either [(131)I]MIBG or radioactive somatostatin analogs.
  60. ncbi Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours
    I M Modlin
    Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Aliment Pharmacol Ther 31:169-88. 2010
    The discovery of somatostatin (SST) and the synthesis of a variety of analogues constituted a major therapeutic advance in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours (GEP-NETs)...
  61. ncbi Long-acting somatostatin analog therapy of acromegaly: a meta-analysis
    Pamela U Freda
    Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 90:4465-73. 2005
    Although considerable data exist on the use of long-acting somatostatin analogs to treat acromegaly, their reported efficacy differs substantially among trials.
  62. ncbi Neuroendocrine-immune interactions: the role of cortistatin/somatostatin system
    Diego Ferone
    Department of Endocrinological and Metabolic Sciences, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Ann N Y Acad Sci 1069:129-44. 2006
    ..Herein, we focus on somatostatin (SS), a ubiquitous peptide that regulates several physiological cell processes and acts via five specific ..
  63. ncbi Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy
    Kjell E Oberg
    Department of Endocrine Oncology, University Hospital, Uppsala, Sweden
    Gastroenterology 139:742-53, 753.e1. 2010
    ..Most GEP-NETs overexpress the somatostatin receptor SSTR2; somatostatin analogues are the best therapeutic option for functional neuroendocrine tumors ..
  64. ncbi Targeted cytotoxic somatostatin analog AN-162 inhibits growth of human colon carcinomas and increases sensitivity of doxorubicin resistant murine leukemia cells
    Florian Hohla
    Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Private Medical University of Salzburg, Paracelsusstrasse 37, Oberndorf, Austria
    Cancer Lett 294:35-42. 2010
    The effect of the targeted cytotoxic somatostatin (SST) analog AN-162, consisting of doxorubicin (DOX) conjugated to SST carrier RC-121, was investigated on the growth of human colorectal cancer (CRC) cell lines HT-29, HCT-15, and HCT-116 ..
  65. pmc Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT(3A)R expression
    Ramesh Chittajallu
    1 Program in Developmental Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Neurosci 16:1598-607. 2013
    ..Thus, members of a seemingly uniform interneuron population can exhibit unique circuit functions and neuromodulatory properties dictated by disparate developmental origins...
  66. ncbi Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study
    Tullio Florio
    Department of Oncology, Biology and Genetics, University of Genova, Viale Benedetto XV, 2, 16132 Genova, Italy
    Endocr Relat Cancer 15:583-96. 2008
    Dopamine D2 and somatostatin receptors (sstrs) were reported to affect non-functioning pituitary adenoma (NFPA) proliferation in vitro. However, the reported results differ according to the experimental conditions used...
  67. ncbi Null mutant mouse models of somatostatin and cortistatin, and their receptors
    T Zeyda
    John A Burns School of Medicine, Honolulu, HI, USA
    Mol Cell Endocrinol 286:18-25. 2008
    b>Somatostatin (somatotropin release inhibitory factor, SRIF) and the related cortistatin (CST) are multifunctional peptide molecules attributed with neurohormone, neurotransmitter/modulator, and autocrine/paracrine actions...
  68. ncbi Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat
    Zsuzsanna Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643 Pecs, Szigeti u 12, Hungary
    Arthritis Rheum 50:1677-85. 2004
    We previously demonstrated that somatostatin (SOM) released from the activated peripheral terminals of capsaicin-sensitive primary sensory neurons inhibits acute inflammation and nociception...
  69. ncbi Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells
    Virgil A S H Dalm
    Dept of Internal Medicine, Rm Bd 240, Erasmus MC, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 285:E344-53. 2003
    ..A differential expression of the five known somatostatin (SS) receptors (sst1-5) has been demonstrated in human immune cells and tissues...
  70. ncbi Somatostatin analogues, a series of tissue transglutaminase inducers, as a new tool for therapy of mesenchimal tumors of the gastrointestinal tract
    G Palmieri
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Amino Acids 32:395-400. 2007
    ..The present study was performed to analyse the expression of somatostatin receptor (SSTR) subtypes, modulators of tissue transglutaminase, in a series of GISTs and leiomyosarcomas by ..
  71. ncbi Preclinical evaluation of therapeutic effects of targeted cytotoxic analogs of somatostatin and bombesin on human gastric carcinomas
    Karoly Szepeshazi
    Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, New Orleans, Louisiana 70112, USA
    Cancer 98:1401-10. 2003
    ..The authors investigated whether receptors for somatostatin and bombesin were present in human gastric carcinoma lines and tested the antitumor effects of cytotoxic ..
  72. ncbi Inhibition of human non-small cell lung cancers with a targeted cytotoxic somatostatin analog, AN-162
    Andrea Treszl
    Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education, 1201 NW 16th Street, Miami, FL 33125, USA
    Peptides 30:1643-50. 2009
    Human non-small cell lung cancers (NSCLCs) express receptors for somatostatin. The cytotoxic analog of somatostatin AN-162 (AEZS-124), consisting of doxorubicin linked to a somatostatin analog RC-121 binds to receptors for somatostatin ..
  73. ncbi Lower somatostatin expression is an early event in diabetic retinopathy and is associated with retinal neurodegeneration
    Esther Carrasco
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 30:2902-8. 2007
    To test the hypothesis that a reduction of somatostatin (SST) in the retina exists in patients without clinically detectable diabetic retinopathy and that it is associated with retinal neurodegeneration.
  74. ncbi Preclinical evaluation of properties of a new targeted cytotoxic somatostatin analog, AN-162 (AEZS-124), and its effects on tumor growth inhibition
    Stephan Seitz
    Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center Florida, South Florida VA Foundation for Research and Education, Florida, USA
    Anticancer Drugs 20:553-8. 2009
    In view of findings that various tumors express receptors for somatostatin, a new targeted cytotoxic analog of somatostatin, AN-162 (AEZS-124), consisting of doxorubicin linked through glutaric acid to the somatostatin octapeptide RC-121 ..
  75. pmc Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons
    Myrto Denaxa
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, United Kingdom
    Cell Rep 2:1351-62. 2012
    ..but the molecular mechanisms that operate downstream of LHX6 to control the terminal differentiation of somatostatin- and parvalbumin-expressing interneurons within the cortex remain unknown...
  76. ncbi Pasireotide (SOM230) shows efficacy and tolerability in the treatment of patients with advanced neuroendocrine tumors refractory or resistant to octreotide LAR: results from a phase II study
    Larry K Kvols
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Endocr Relat Cancer 19:657-66. 2012
    Pasireotide (SOM230) is a novel multireceptor-targeted somatostatin (sst) analog with high binding affinity for sst receptor subtype 1, 2, 3 (sst(1,2,3)) and sst(5)...
  77. ncbi Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway
    Harvinder S Chahal
    Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 97:E1411-20. 2012
    Somatotroph adenomas harboring aryl hydrocarbon receptor interacting protein (AIP) mutations respond less well to somatostatin analogs, suggesting that the effects of somatostatin analogs may be mediated by AIP.
  78. ncbi Control of signalling properties of human somatostatin receptor subtype-5 by additional signal sequences on its amino-terminus in yeast
    Yusuke Iguchi
    Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe 657 8501, Japan
    J Biochem 147:875-84. 2010
    ..Prepro and pre regions of alpha-factor and amino-terminal sequence of Ste2 (Ste2N) were used as SS, and somatostatin (SST) receptor subtype-5 (SSTR5) was used as a model GPCR...
  79. ncbi Combined effects of melatonin and all-trans retinoic acid and somatostatin on breast cancer cell proliferation and death: molecular basis for the anticancer effect of these molecules
    Martina Margheri
    Department of Anatomy, Histology, Forensic Medicine, University of Florence, 50134 Florence, Italy
    Eur J Pharmacol 681:34-43. 2012
    ..All-trans retinoic acids or somatostatin have been used in combination with melatonin in several pre-clinical and clinical trials, but they have never ..
  80. pmc Clinical efficacy and safety results for dose escalation of somatostatin receptor ligands in patients with acromegaly: a literature review
    Maria Fleseriu
    Department of Neurological Surgery, Northwest Pituitary Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, BTE 472, Portland, OR 97239, USA
    Pituitary 14:184-93. 2011
    ..b>Somatostatin receptor ligands (SRLs) are considered the standard medical choice for the treatment of acromegaly, and ..
  81. ncbi Comparison of 18F-DOPA, 18F-FDG and 68Ga-somatostatin analogue PET/CT in patients with recurrent medullary thyroid carcinoma
    Giorgio Treglia
    Institute of Nuclear Medicine, Policlinico A Gemelli, Catholic University of the Sacred Heart, Rome, Italy
    Eur J Nucl Med Mol Imaging 39:569-80. 2012
    To retrospectively evaluate and compare (18)F-FDG, (18)F-DOPA and (68)Ga-somatostatin analogues for PET/CT in patients with residual/recurrent medullary thyroid carcinoma (MTC) suspected on the basis of elevated serum calcitonin levels.
  82. ncbi Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt
    M C Zatelli
    Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy
    J Clin Endocrinol Metab 86:2161-9. 2001
    b>Somatostatin and its receptors (SSTR1 to SSTR5) are expressed in normal human parafollicular C cells and medullary thyroid carcinoma (MTC), but the role of SSTR subtypes in cell growth regulation is still not clear...
  83. ncbi Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone
    Aart Jan van der Lely
    Department of Internal Medicine, Erasmus University MC, 40 Dr Molewaterplein, 3015 GD Rotterdam, The Netherlands
    Eur J Endocrinol 164:325-33. 2011
    ..To evaluate the efficacy and safety of coadministered lanreotide Autogel (LA; 120  mg/month) and pegvisomant (40-120  mg/week) in acromegaly...
  84. pmc Comparison of the activation of somatostatin- and neuropeptide Y-containing neuronal populations of the rat amygdala following two different anxiogenic stressors
    Ryan K Butler
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Exp Neurol 238:52-63. 2012
    ..of the brains were prepared for dual-labeled immunohistochemistry and counts of c-Fos co-localized with somatostatin (SOM) or neuropeptide Y (NPY) were made in the basolateral (BLA), central (CEA), medial (MEA) nuclei of the ..
  85. ncbi Novel pathway for somatostatin analogs in patients with acromegaly
    Monica R Gadelha
    Division of Endocrinology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Professor Rodolpho Paulo Rocco street 255, Rio de Janeiro, Brazil
    Trends Endocrinol Metab 24:238-46. 2013
    ..The somatostatin analogs (SSAs) are the mainstay of medical therapy but, in many patients, including those with a germline ..
  86. ncbi A combination therapy of dexamethasone and somatostatin analog reintroduces objective clinical responses to LHRH analog in androgen ablation-refractory prostate cancer patients
    M Koutsilieris
    Department of Experimental Physiology, Medical School, University of Athens, Athens, 11527 Greece
    J Clin Endocrinol Metab 86:5729-36. 2001
    ..We evaluated whether the combination of triptorelin, a LHRH analog (LHRH-A), with dexamethasone and lanreotide, a somatostatin analog, can produce objective clinical responses in metastatic androgen ablation-refractory prostate cancer (..
  87. ncbi Somatostatin receptor subtypes mediate contractility on human colonic smooth muscle cells
    V D Corleto
    Department of Digestive and Liver Diseases, 1st and 2nd Schools of Medicine, University La Sapienza, Rome, Italy
    Neurogastroenterol Motil 18:217-25. 2006
    This study demonstrates the expression of functional somatostatin receptor (sstr) subtypes in human circular and longitudinal colonic smooth muscle cells (SMC)...
  88. ncbi Dosimetry for treatment with radiolabelled somatostatin analogues. A review
    M Cremonesi
    Medical Physics, European Institute of Oncology, Milan, Italy
    Q J Nucl Med Mol Imaging 54:37-51. 2010
    ..Peptide Receptor Radionuclide Therapy (PRRT) has proven its efficacy in the treatment of neuroendocrine and other somatostatin receptor expressing tumours (SR-tumours)...
  89. pmc Activation of brain somatostatin 2 receptors stimulates feeding in mice: analysis of food intake microstructure
    Andreas Stengel
    CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and Veterans Affairs Greater Los Angeles Health Care System, CA 90073, USA
    Physiol Behav 101:614-22. 2010
    We recently reported that the oligosomatostatin receptor agonist, ODT8-SST increases food intake in rats via the somatostatin 2 receptor (sst(2))...
  90. pmc Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease
    Marie C Hogan
    Division of Nephrology and Hypertension, Department of Biomedical STatistics and Informatics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 21:1052-61. 2010
    ..dominant PLD (ADPLD) in a randomized, double-blind, placebo-controlled trial of octreotide, a long-acting somatostatin analogue...
  91. ncbi Impairment in motor learning of somatostatin null mutant mice
    T Zeyda
    Unit on Molecular Genetics, Clinical Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res 906:107-14. 2001
    b>Somatostatin was first identified as a hypothalamic factor which inhibits the release of growth hormone from the anterior pituitary (somatotropin release inhibitory factor, SRIF)...
  92. ncbi Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex
    Luc J Gentet
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, Switzerland
    Nat Neurosci 15:607-12. 2012
    ..We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake behaving mice...
  93. ncbi Expression and localisation of somatostatin receptor subtypes sst1-sst5 in areas of the rat medulla oblongata involved in autonomic regulation
    Emma J Spary
    Academic Unit of Cardiovascular Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    J Chem Neuroanat 35:49-66. 2008
    b>Somatostatin is known to modulate the activity of neurones of the medulla oblongata involved in autonomic regulation, mediated through five subtypes of G protein-coupled receptors, sst1-sst5...
  94. ncbi Biodistribution of the Ga-68 labeled somatostatin analogue DOTA-NOC in patients with neuroendocrine tumors: characterization of uptake in normal organs and tumor lesions
    V Prasad
    Department of Nuclear Medicine Center for PET, Zentralklinik Bad Berka, Bad Berka, Germany
    Q J Nucl Med Mol Imaging 54:61-7. 2010
    The aim of the study was 1) to determine the normal biodistribution of radiolabeled somatostatin analogue (68)Ga DOTA-NOC; 2) to establish the range of its uptake in liver, bone and lymph node metastases in patients with NET, 3) to ..
  95. ncbi Long acting somatostatin analogues in combination to antineoplastic agents in the treatment of small cell lung cancer patients
    K Zarogoulidis
    Lung Tumour Research Section, Pulmonary Department, Aristotle University Pulmonary Clinic, G Papanikolaou Hospital, Exohi, Thessaloniki, Greece
    Lung Cancer 76:84-8. 2012
    Long acting somatostatin analogues combined with platinum analogues have demonstrated an antiproliferative effect on growth of human SCLC xenographs.
  96. ncbi The inhibitory effect of a novel cytotoxic somatostatin analogue AN-162 on experimental glioblastoma
    E Pozsgai
    Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education, Miami, FL 33125, USA
    Horm Metab Res 42:781-6. 2010
    ..Based on earlier promising results earned with AN-162, a doxorubicin molecule linked to somatostatin (SST) analogue RC-160, it was our aim to determine the effect of AN-162 on DBTRG-05 glioblastoma cell line, and ..
  97. ncbi Treatment of neuroendocrine GEP tumours with somatostatin analogues: a review
    R Arnold
    Department of Internal Medicine, Philipps University, Marburg, Germany
    Digestion 62:84-91. 2000
    b>Somatostatin and its long-acting analogues are effective in symptom control in patients with functionally active neuroendocrine GEP tumours. Several in vitro and in vivo reports suggest that they are also able to control tumour growth.
  98. ncbi Somatostatin and its receptors from fish to mammals
    Manuel D Gahete
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Spain
    Ann N Y Acad Sci 1200:43-52. 2010
    b>Somatostatin (SST) and its receptors (sst) make up a molecular family with unique functional complexity and versatility...
  99. pmc Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region
    Alice Y Wang
    Neuroscience Program for Undergraduates, Vanderbilt University, Nashville, TN, USA
    Acta Neuropathol 122:615-26. 2011
    ..specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons...
  100. ncbi Parvalbumin, somatostatin and cholecystokinin as chemical markers for specific GABAergic interneuron types in the rat frontal cortex
    Yasuo Kawaguchi
    Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    J Neurocytol 31:277-87. 2002
    ..shown in separate groups of GABA cells in layers II/III and V of the frontal cortex: (1) parvalbumin cells, (2) somatostatin cells, (3) calretinin and/or vasoactive intestinal polypeptide (VIP) cells [partially positive for ..
  101. ncbi Experience with indium-111 and yttrium-90-labeled somatostatin analogs
    I Virgolini
    Department of Nuclear Medicine, University of Vienna, A 1090, Vienna, Austria
    Curr Pharm Des 8:1781-807. 2002
    The high level expression of somatostatin receptors (SSTR) on various tumor cells has provided the molecular basis for successful use of radiolabeled octreotide / lanreotide analogs as tumor tracers in nuclear medicine...

Research Grants76

  1. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..as well as (c) Brain expression of histidine decarboxylase (HDC), CRN, beta-endorphin, IL-6, IL- 8, IL-17, somatostatin, TNF, mouse mast cell protease (MMCP), urocortin 2, UCP2 and VEGF;(2) The requirement for mast cells, for NT, ..
  2. In vivo targeted gene silencing, a novel method
    WILLIAM ANTHONY TRUITT; Fiscal Year: 2012
    ..These Tacr1 interneurons represent a subpopulation of BLA-interneurons that contain the neuropeptides somatostatin (Sst) and cholecystokinin (Cck), and although these cells appear to be pivotal in the regulation of anxiety-..
  3. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
    ..Experiments proposed in Aim 2 seek to test two classes of compounds, somatostatin and its analogs, and adenosine and its analogs, for their ability to diminish glutamate release during control ..
  4. Modulation of insulin and glucagon secretion by GPCR ligands
    TARA ASHLEY SCHWETZ; Fiscal Year: 2011
    ..In contrast, NPY has been shown to stimulate glucagon secretion from mouse and rat islets. Somatostatin (SST) is secreted by the pancreatic / cells and has two active forms-SST-14 and SST-28...
  5. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..b>Somatostatin will be used when required to disable the endocrine pancreas, along with intraportal infusion of insulin and ..
  6. Molecular mechanism of antiangiogenic properties of gold nanoparticle
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..factors such as VPF/VEGF165, PLGF, etc, and antiangiogenic factors such as thrombospondin-1 (TSP-1), somatostatin, endostatin, etc. Disruption of this equilibrium under pathological conditions turns on the "angiogenic switch"...
  7. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..The work will focus on pyramidal cells, PV+ cells, cholecystokinin-expressing (CCK+) cells and somatostatin-containing (SOM+) interneurons...
  8. Mechanisms of abnormal enterochromaffin cell secretion in Crohn's disease
    Mark S Kidd; Fiscal Year: 2012
    ..and strain mediated serotonin synthesis and secretion, or a loss of normal inhibitory responses to somatostatin and acetylcholine...
  9. Mechanisms of oval cell activation and differentiation
    Bryon E Petersen; Fiscal Year: 2013
    ..Previous experiments have implicated connective tissue growth factor (CTGF), Notch-1, Wnt1, Somatostatin (SST), insulin-like growth factor binding protein 3 (IGFBP3) as playing key-roles in the liver stem cell ..
  10. GENETIC ORGANIZATION OF RESPIRATORY CIRCUITS IN MOUSE BRAINSTEM
    Paul Gray; Fiscal Year: 2013
    ..We will determine the ability to respond to changes in pH or to the activation of opioid and/or somatostatin receptors is limited to specific genetic lineages...
  11. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    ..we have demonstrated (see preliminary data) a significant decrease in the frontal cortical gene expression of somatostatin, fibroblast growth factor-2 (FGF2) and growth arrest and DNA-damage-inducible-beta (GADD45B), and an increase ..
  12. Role of Cyclins in Brain Construction and Interneuron Genesis
    KRISTIN GIAMANCO; Fiscal Year: 2013
    ..mouse neocortex and the medial ganglionic eminence (MGE), the origin of cortical parvalbumin (PV)- and somatostatin (SST)-expressing interneurons...
  13. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2013
    ..in prenatal cortical development, but may increase the differentiation or survival of cortical parvalbumin+ and somatostatin+ inhibitory interneurons by an action in postnatal glial cells...
  14. Motivational Changes for Nutritionally Relevant Tastes after Gastric Bypass
    Alan C Spector; Fiscal Year: 2013
    ..Systemic administration of the somatostatin analog, octreotide, which blocks the release of these and other gut hormones, doubles short-term chow intake in ..
  15. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    CLAUDIA T KAPPEN; Fiscal Year: 2010
    ..Preliminary quantitative real-time PCR results implicate the somatostatin and Wnt signaling pathways in Isl-l-induced caudal growth defects...
  16. The Functional Maturation of Inhibitory Interneurons
    MATTHEW LAZARUS; Fiscal Year: 2010
    ..cells, which have a fast-spiking phenotype and provide proximal inhibition to or near to the cell body, and somatostatin expressing cells, which have a regular-spiking phenotype and provide distal inhibition to the dendrites...
  17. TRAINING PROGRAM IN MOLECULAR ENDOCRINOLOGY
    David D Moore; Fiscal Year: 2012
    ..Structure/function analysis of sulfonylurea receptors and ATP-sensitive K + channels and interactions with the somatostatin receptor...
  18. Nkx2.2 in Pancreatic Development: The Role of the NK2-SD Domain
    JOSHUA ADAM LEVINE; Fiscal Year: 2013
    ..cells, insulin- producing [unreadable] cells, somatostatin-producing d cells, pancreatic polypeptide-producing PP cells, and ghrelin- producing e cells...
  19. Novel treatment for polycystic kidney disease
    Vicente E Torres; Fiscal Year: 2013
    ..led to currently active clinical trials of arginine vasopressin (AVP) V2 receptor antagonists and long-acting somatostatin analogs...
  20. Development of a kit based PET molecular imaging agent: edotreotide Ga 68 for so
    James F Kronauge; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Synthetic peptides targeted to Somatostatin receptors (SSTR) were developed almost 30 years ago by Novartis to inhibit the effects of endogenous growth factors on malignant tissues...
  21. Nociceptive Role of SST and NT receptor-expressing dorsal horn neurons
    RONALD GORDON WILEY; Fiscal Year: 2013
    ..which given intrathecally activate receptors on inhibitory SDH interneurons and produce analgesia in humans, somatostatin (SST), or anti-nociception in animals, neurotensin (NTS)...
  22. RECEPTOR-TARGETED COPPER RADIOPHARMACEUTICALS FOR CANCER IMAGING AND THERAPY
    Carolyn J Anderson; Fiscal Year: 2012
    ABSTRACT: The long-range goal of this research is the development of radiolabeled somatostatin-receptor ligands for positron emission tomography (PET) imaging and targeted radiotherapy of cancer...
  23. Corticolimbic Somatostatin-Related Inhibitory Dysfunction in Major Depression
    Etienne L Sibille; Fiscal Year: 2013
    ..We have now identified a selective downregulation of somatostatin (SST), an inhibitory neuropeptide expressed in a subset of GABA neurons, in the DLPFC, sgACC and amygdala of ..
  24. Pancreatic endocrine network control of glucagon counterregulation
    Anthony L McCall; Fiscal Year: 2013
    ..confirmed that, in diabetic rats, pulsatile GCR can be amplified by intrapancreatic infusion of insulin and somatostatin if these signals are terminated during hypoglycemia [switch-off signals]...
  25. GABA Receptors and Hilar Neuron Survival in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    ..Two major groups of hilar neurons are frequently damaged, GABAergic somatostatin interneurons and glutamatergic mossy cells...
  26. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    RODERICK PAUL ROBERTSON; Fiscal Year: 2013
    ..fasts;meal-induced hypoglycemia with and without somatostatin infusion;and exercise- induced hypoglycemia with bicycle at 40% of peak Vo2...
  27. The role of central IGF- 1 feedback in the regulation of growth and metabolism
    CHRISTOPHER JOSEPH ROMERO; Fiscal Year: 2013
    ..Compensatory changes were noted with decreased growth hormone releasing hormone and increased somatostatin mRNA expression levels in the hypothalamus...
  28. Role of Notch signaling in the Development and Guidance of Hypothalamic Neurons
    PAVEN AUJLA; Fiscal Year: 2013
    ..Hypothalamic neurons that project to the anterior lobe through the median eminence (ME), such as somatostatin (SS), are affected by both hypopituitarism and multiple anterior pituitary hormone deficiency (MPHD;1:4000-1:10,..
  29. Neurotransmitter Regulation of Glial Cytokine Expression
    BRYAN SPANGELO; Fiscal Year: 2009
    ..activated protein kinase (MARK) compromises IL-1 action in C6 cells, as do the inhibitory neurotransmitters somatostatin (SRIF) and gamma-aminobutyric acid (GABA)...
  30. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    Paul S Buckmaster; Fiscal Year: 2013
    ..We will use GIN mice, which express green fluorescent protein (GFP) in a subset of somatostatin interneurons...
  31. Deconvoluting microRNA expression in brain
    Richard H Goodman; Fiscal Year: 2013
    ..sensors, we found, unexpectedly, that miR-134 activity in mature cortical neurons was limited to inhibitory somatostatin (SST)-producing interneurons, contradicting a widely held view of miR-134 function...
  32. Pancreatic Islets Dynamics Regulating Glucagon Secretion
    David W Piston; Fiscal Year: 2013
    ..on [unreadable]-cells, although other islet hormones including glucagon (secreted by [unreadable]-cells) and somatostatin (secreted by [unreadable]-cells) have important physiological actions...
  33. Somatostatin Agonist Treatment for Cognitive Aging and Dementia
    Ken A Witt; Fiscal Year: 2010
    ..A promising avenue for treatment of AD is through the use of selective somatostatin receptor (SSTR) agonists...
  34. Polyacridine Peptide Mediated Gene Targeting
    Kevin G Rice; Fiscal Year: 2013
    ..PPAPs) containing a fusogenic peptide and octreotide as a high affinity ligand to target cells expressing the somatostatin subtype-2 receptor (SS2)...
  35. Systematic Evaluation of Sensory Processing in Distinct Interneuron Types
    CHRISTOPHER IRWIN MOORE; Fiscal Year: 2012
    ..This type is typically regular-spiking and somatostatin expressing...
  36. A Tonically Active Network in the Neostriatum
    Charles J Wilson; Fiscal Year: 2013
    ..by way of neuromodulatory control of excitability and synaptic plasticity via acetylcholine, nitric oxide, somatostatin, and neuropeptide Y...
  37. A kit based PET agent: edotreotide Ga 68 for clinical imaging of somatostatin rec
    James F Kronauge; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): A kit based PET agent: edotreotide Ga 68 for clinical imaging of somatostatin receptor expressing tissue...
  38. The role of EphA-ephrin-A signaling in glucose-inhibition of glucagon secretion
    Troy Hutchens; Fiscal Year: 2013
    ..signaling, as sorted [unreadable]-cells are no longer sensitive to proposed paracrine inhibitors (insulin and somatostatin)...
  39. Epigenetic Actions of Growth Hormone
    Dennis J Chia; Fiscal Year: 2012
    ..The long-acting somatostatin analog, octreotide, will be utilized to suppress endogenous GH secretion...
  40. The Development and Integration of Early Born SST-Expressing
    GORDON J FISHELL; Fiscal Year: 2013
    ..In this proposal, we will specifically focus on the development of somatostatin-expressing cortical interneurons within this region of the neocortex...
  41. Generation of interneurons derived from ES cells using inducible expression of tr
    Timothy J Petros; Fiscal Year: 2013
    ..stem (ES) cells is handicapped by the small percentage of interneurons produced and the biased production of somatostatin- expressing (Sst+) interneurons over other subgroups...
  42. ACTIONS OF TESTOSTERONE ON THE AGING MALE GH AXIS
    Johannes D Veldhuis; Fiscal Year: 2013
    ..The minimal ensemble comprises GH-releasing hormone (GHRH), somatostatin (SS), GH-releasing peptide (ghrelin, GHRP), and GH and IGF-I...
  43. Novel Interneurons Mediating Feedforward Inhibition
    Ariel Agmon; Fiscal Year: 2013
    ..The two largest and best studied inhibitory subtypes are "fast spiking" interneurons and somatostatin-containing interneurons...
  44. Cellular mechanisms of GABAergic inhibition in neocortical dendrites
    MICHAEL JAMES HIGLEY; Fiscal Year: 2013
    ..Dendrite-targeting interneurons that express the peptide somatostatin (SOM-INs) are hypothesized to provide negative feedback to distal PN dendrites that scales with local network ..
  45. Biased Agonism In GPCR Drug Discovery: Application To Somatostatin Agonists
    RICHARD SCOTT STRUTHERS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neuropeptide somatostatin analogs are important therapeutics for the treatment of hormone secreting tumors with annual sales of ~$1.7B...
  46. NEUROCHEMICAL PATHWAYS IN THE INNER RETINA
    NICHOLAS BRECHA; Fiscal Year: 2009
    ..The focus of proposed studies is on somatostatin (SRIF) and its Gi/o-protein coupled receptors (sst1-sst5)...
  47. G PROTEIN COUPLED RECEPTOR ACTIVATION STUDIED IN YEAST
    Mark Dumont; Fiscal Year: 2009
    ..in yeast to pursue a step-by-step dissection of the mechanisms of GPCR signaling by heterologously expressed somatostatin type 2 receptor and the endogenous yeast receptor for the a-mating pheromone, two receptors that can activate ..
  48. GASTRIC ENTEROCHROMAFFIN-LIKE CELL IN ULCER DISEASE
    George Sachs; Fiscal Year: 2005
    ..H. pylori modifies secretion of gastrin and somatostatin and is also a major contributor to ulcerogenesis...
  49. NEUROCHEMICAL PATHWAYS IN THE INNER RETINA
    Nicholas C Brecha; Fiscal Year: 2013
    ..The focus of the proposed studies is on somatostatin (SRIF) and its Gi/o- protein coupled receptors (sst1-sst5)...
  50. The role of dendrite-targeting interneurons in auditory cortex
    BRYAN SEYBOLD; Fiscal Year: 2013
    ..As one particular example, somatostatin-positive interneurons synapse predominantly onto the apical dendrites of pyramidal neurons...
  51. Quantitative ECT for Complex Imaging Tasks
    Stephen C Moore; Fiscal Year: 2012
    ..We will consider clinical tasks related to treatment planning for radiotherapy of tumors expressing somatostatin receptors, as well as to treatment of hepatic tumors and metastases with 90Y- labeled microspheres, and to the ..
  52. Dosimetry Guided Phase II of 90Y-DOTA-tyr3-Octreotide + Retinoic Acid in Kids
    M SUE SUE O apos DORISIO; Fiscal Year: 2010
    ..and young adults with recurrent solid tumors using 90Y-DOTA-tyr3-Octreotide (90Y-DOTATOC) to target the somatostatin receptor type 2 (sst2) expressed on tumor cells...
  53. Hippocampal inhibitory neuronal circuit organization
    Xiangmin Xu; Fiscal Year: 2013
    ..PV+) basket cells, cholecystokinin- expressing (CCK+) basket cells, axo-axonic cells, and somatostatin-expressing (SOM+) oriens-lacunosum moleculare (O-LM) cells...
  54. Inhibitory regulation of cortical visual processing
    Jessica A Cardin; Fiscal Year: 2013
    ..The two largest groups are the parvalbumin-expressing interneurons that target the soma and the somatostatin-expressing interneurons that target the dendrites...
  55. Methamphetamine and the Striatal NK-1 Receptors
    JESUS ALEXANDER ANGULO; Fiscal Year: 2010
    ..This in turn causes excessive release of substance P (SP), which then acts through NK-1Rs on cholinergic and somatostatin/NOS interneurons. In the latter neurons, nNOS is up-regulated and excessive NO produced...
  56. The functional role of interneuron classes in the mouse visual cortex
    Wei Chung Allen Lee; Fiscal Year: 2010
    ..Too little is known of other classes, such as low-threshold spiking, somatostatin-positive cells, to make specific predictions about them...
  57. Regulation of somatostatin receptor signaling
    Agnes Schonbrunn; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Regulation of somatostatin receptor signaling (Schonbrunn) Somatostatin (SS) receptor 2A (sstr2A) is the most widely expressed SS receptor subtype in normal tissues and human tumors...
  58. Modulation of cortical processing by engagement with the sensory environment
    Michael Goard; Fiscal Year: 2013
    ..express red fluorescent protein (TdTomato) in cell types of interest (specifically, parvalbumin-positive and somatostatin- positive interneurons;Aim 2)...
  59. Regulation of Olfactory Cortex Odor Responses by Somatostatin Interneurons
    James F Sturgill; Fiscal Year: 2013
    ..We propose to study the function, in vivo, of a major group of inhibitory neurons that express the marker gene somatostatin (SOM), in order to better understand how the neuronal activity of olfactory cortex is regulated...
  60. HYPOTHALAMIC HORMONES IN PANCREATIC CANCER
    Andrew Schally; Fiscal Year: 1991
    Analogs of hypothalamic hormones somatostatin and luteinizing hormone-releasing hormone (LH-RH) given alone or in combination will be tested in rat and hamster models of transplanted acinar and ductal pancreatic carcinomas and in nude ..
  61. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2007
    ..Another neuropeptide, somatostatin, stimulates Th2 cytokine production and impairs granuloma formation...
  62. The Role of Glucose Mediated Glucose Uptake in the pathogenesis of IFG and IGT
    Muhammad Abdul-Ghani; Fiscal Year: 2013
    ..In this grant proposal we will: (i) quantitate whole body GMGU with the stepped hyperglycemic clamp and somatostatin infusion, and insulin-mediated glucose uptake (IMGU) with the stepped euglycemic insulin clamp, (ii) the ..
  63. DOSIMETRY IN CHILDREN AND YOUNG ADULTS WITH NEUROBLASTOMA OR NEUROENDOCRINE TUMOR
    M SUE O DORISIO; Fiscal Year: 2009
    ..theoretical advantage of combined radiotherapy targeting the amine transporter (VMAT1) using 131I-MIBG and a somatostatin receptor (sst2) using 90Y-DOTA-tyr3-Octreotide in order to maximize the radiation dose to tumor while ..
  64. The role of inhibition in the mapping and plasticity of representations in V1
    CAROLINE ANNE RUNYAN; Fiscal Year: 2011
    ..soma-targeting parvalbumin-positive (PV+), dendrite-targeting calretinin-positive (CR+), and dendrite-targeting somatostatin- positive cells (SOM+)...
  65. SOMATOSTATIN RECEPTORS--CLASSIFICATION OF NEUROBLASTOMAS
    M O DORISIO; Fiscal Year: 1999
    ..Preliminary Data from our laboratory suggests a role for somatostatin in regulation of neuroblastoma cell growth...
  66. GRANULOMA REGULATION THROUGH SOMATOSTATIN RECEPTOR SSTR2
    David Elliott; Fiscal Year: 2000
    ..Much of this regulatory circuitry proceeds through release of neurokines and other lymphokines. Somatostatin (SOM) is one such neurokine that alters lymphocyte responses. Granuloma macrophages secrete SOM...
  67. CHEMISTRY AND BIOLOGY OF GUT PANCREASTATIN
    JOHN DELVALLE; Fiscal Year: 1992
    ..49 amino acid peptide recently isolated from porcine pancreas, has been shown to inhibit glucose stimulated somatostatin and insulin release from the isolated perfused pancreas...
  68. Astatine 211 & Radioiodine Labeled Octreotide Conjugates
    Michael Zalutsky; Fiscal Year: 2004
    DESCRIPTION (Provided by Applicant): Somatostatin receptors, particularly the somatostatin receptor subtype 2 (sst2), are found on many tumor types...
  69. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Endogenous somatostatin receptors (SSTRs) offer novel targets for treating pain via both peripheral and central mechanisms...
  70. LH-RH ANALOGS IN BREAST AND OVARIAN CANCER
    Andrew Schally; Fiscal Year: 1991
    ..2) combination regimens of D-Trp-6-LH-RH microcapsules with a) other peptides, especially superactive somatostatin analogs of D-Phe-Cys- Tyr-D-Trp-Lys-Val-Cys-Trp-Nh2 (RC-160) class and microcapsules thereof; b) with ..
  71. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2002
    ..Our work has demonstrated expression of somatostatin receptors in both primary tumors and cell lines...
  72. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2003
    ..Our work has demonstrated expression of somatostatin receptors in both primary tumors and cell lines...
  73. Function of Nkx homeobox genes in enteroendocrine cell differentiation
    TRACY EDIGER; Fiscal Year: 2009
    ..The homeodomain protein Nkx6.3 controls terminal differentiation of G cells as well as somatostatin-producing D cells in the stomach antrum;gastrin and somatostatin levels are respectively elevated and reduced ..
  74. Intraislet Communication in Surgically-Altered Pancreas
    FRANCIS BRUNICARDI; Fiscal Year: 2007
    ..Preliminary data suggest the presence of a delta-to-beta cell endocrine axis within the islet in which intraislet somatostatin inhibits insulin secretion...
  75. SIGNALING MECHANISMS OF SOMATOSTATIN RECEPTORS
    DIANE BARBER; Fiscal Year: 2002
    ..The overall objective of this proposal is to determine signaling networks mediating the inhibitory actions of the somatostatin receptor subtype SSTR1...
  76. Regulation of Mouse Somatostatin Receptor Subtype 5 Gene
    WHITNEY WOODMANSEE; Fiscal Year: 2004
    ..proposal is to expand our understanding of the basic molecular mechanism(s) regulating expression of the mouse somatostatin receptor subtype 5 gene (sst5)...