melatonin

Summary

Summary: A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.

Top Publications

  1. ncbi Melatonin signaling and cell protection function
    Francesca Luchetti
    Dipartimento di Scienze Dell Uomo dell Ambiente e della Natura, Universita degli Studi di Urbino Carlo Bo, Urbino, Italy
    FASEB J 24:3603-24. 2010
  2. ncbi On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK
    Annia Galano
    Departamento de Quimica, Universidad Autonoma Metropolitana Iztapalapa, DF, Mexico
    J Pineal Res 54:245-57. 2013
  3. ncbi Melatonin as a natural ally against oxidative stress: a physicochemical examination
    Annia Galano
    Departamento de Química Universidad Autónoma Metropolitana Iztapalapa Col Vicentina Iztapalapa México D F México
    J Pineal Res 51:1-16. 2011
  4. ncbi One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    Dun Xian Tan
    Department of Cellular and Structural Biology, The University of Texas, Health Science Center, San Antonio, TX 78229, USA
    J Pineal Res 42:28-42. 2007
  5. ncbi Regulation of antioxidant enzymes: a significant role for melatonin
    Carmen Rodriguez
    Departamento de Morfologia y Biologia Celular, Facultad de Medicina, c Julian Claveria, Oviedo, Spain
    J Pineal Res 36:1-9. 2004
  6. ncbi Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-κB and Nrf2 cascades
    Geeta Negi
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    J Pineal Res 50:124-31. 2011
  7. ncbi Melatonin--a pleiotropic, orchestrating regulator molecule
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Goettingen, Berliner Str 28, Lower Saxony, D 37073 Goettingen, Germany
    Prog Neurobiol 93:350-84. 2011
  8. ncbi Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Germany
    J Pineal Res 52:139-66. 2012
  9. pmc Melatonin membrane receptors in peripheral tissues: distribution and functions
    Radomir M Slominski
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Cell Endocrinol 351:152-66. 2012
  10. ncbi Melatonin and its analogs in insomnia and depression
    Daniel P Cardinali
    Departmento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    J Pineal Res 52:365-75. 2012

Detail Information

Publications391 found, 100 shown here

  1. ncbi Melatonin signaling and cell protection function
    Francesca Luchetti
    Dipartimento di Scienze Dell Uomo dell Ambiente e della Natura, Universita degli Studi di Urbino Carlo Bo, Urbino, Italy
    FASEB J 24:3603-24. 2010
    Besides its well-known regulatory role on circadian rhythm, the pineal gland hormone melatonin has other biological functions and a distinct metabolism in various cell types and peripheral tissues...
  2. ncbi On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK
    Annia Galano
    Departamento de Quimica, Universidad Autonoma Metropolitana Iztapalapa, DF, Mexico
    J Pineal Res 54:245-57. 2013
    ..Regarding their relative activity, it was found that AFMK systematically is a poorer scavenger than AMK and melatonin. In aqueous solution, AMK was found to react faster than melatonin with all the studied free radicals, while in ..
  3. ncbi Melatonin as a natural ally against oxidative stress: a physicochemical examination
    Annia Galano
    Departamento de Química Universidad Autónoma Metropolitana Iztapalapa Col Vicentina Iztapalapa México D F México
    J Pineal Res 51:1-16. 2011
    ..b>Melatonin is a ubiquitous and versatile molecule that exhibits most of the desirable characteristics of a good antioxidant...
  4. ncbi One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    Dun Xian Tan
    Department of Cellular and Structural Biology, The University of Texas, Health Science Center, San Antonio, TX 78229, USA
    J Pineal Res 42:28-42. 2007
    b>Melatonin is a highly conserved molecule. Its presence can be traced back to ancient photosynthetic prokaryotes...
  5. ncbi Regulation of antioxidant enzymes: a significant role for melatonin
    Carmen Rodriguez
    Departamento de Morfologia y Biologia Celular, Facultad de Medicina, c Julian Claveria, Oviedo, Spain
    J Pineal Res 36:1-9. 2004
    ..During the last decade, the antioxidant melatonin has been shown to possess genomic actions, regulating the expression of several genes...
  6. ncbi Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-κB and Nrf2 cascades
    Geeta Negi
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    J Pineal Res 50:124-31. 2011
    b>Melatonin exhibits an array of biological activities, including antioxidant and anti-inflammatory actions. Diabetic neuropathy is one of the complications of diabetes with a prevalence rate of 50-60%...
  7. ncbi Melatonin--a pleiotropic, orchestrating regulator molecule
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Goettingen, Berliner Str 28, Lower Saxony, D 37073 Goettingen, Germany
    Prog Neurobiol 93:350-84. 2011
    b>Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues...
  8. ncbi Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Germany
    J Pineal Res 52:139-66. 2012
    Evidence is accumulating regarding the importance of circadian core oscillators, several associated factors, and melatonin signaling in the maintenance of health...
  9. pmc Melatonin membrane receptors in peripheral tissues: distribution and functions
    Radomir M Slominski
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Cell Endocrinol 351:152-66. 2012
    Many of melatonin's actions are mediated through interaction with the G-protein coupled membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or, indirectly with nuclear orphan receptors from the RORα/RZR ..
  10. ncbi Melatonin and its analogs in insomnia and depression
    Daniel P Cardinali
    Departmento de Docencia e Investigación, Facultad de Ciencias Medicas, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
    J Pineal Res 52:365-75. 2012
    ..b>Melatonin has been used for improving sleep in patients with insomnia mainly because it does not cause hangover or show ..
  11. ncbi Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, D 37073 Gottingen, Germany
    J Pineal Res 47:109-26. 2009
    ..AFMK) and N(1)-acetyl-5-methoxykynuramine (AMK) as major brain metabolites of melatonin, these compounds became of particular interest...
  12. ncbi Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells
    Jingshu Wang
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    J Pineal Res 53:77-90. 2012
    b>Melatonin exhibits anti-inflammatory and anticancer effects and could be a chemopreventive and chemotherapeutic agent against cancers, but the precise mechanisms involved remain largely unresolved...
  13. ncbi Basic mechanisms involved in the anti-cancer effects of melatonin
    M D Mediavilla
    Department of Physiology and Pharmacology, School of Medicine, University of Cantabria, 39011 Santander, Spain
    Curr Med Chem 17:4462-81. 2010
    It is commonly accepted that melatonin (N-acetyl-5-methoxytryptamine), the most relevant pineal secretory product, has oncostatic properties in a wide variety of tumors and, especially, in those identified as being hormonedependent...
  14. ncbi A review of the multiple actions of melatonin on the immune system
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
    Endocrine 27:189-200. 2005
    ..the numerous observations published in recent years which have shown that one of the most significant of melatonin's pleiotropic effects is the regulation of the immune system...
  15. ncbi Anti-angiogenic activity of melatonin in advanced cancer patients
    P Lissoni
    Division of Radiation Oncology, San Gerardo Hospital, 20052 Monza, Milan, Italy
    Neuro Endocrinol Lett 22:45-7. 2001
    OBJECTIVES: The anticancer activity of the indole melatonin has been explained to be due to its immunomodulatory, anti-prolferative and anti-oxidant effects, whereas at present no data are available about its possible influence on the ..
  16. pmc Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms
    D J Dijk
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 516:611-27. 1999
    ..polysomnographically recorded sleep episodes (total, 482; 9 h 20 min each) and the circadian rhythms of plasma melatonin and core body temperature. 3. Stage 4 sleep was reduced in older people...
  17. ncbi Actions of melatonin in the reduction of oxidative stress. A review
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Biomed Sci 7:444-58. 2000
    b>Melatonin was discovered to be a direct free radical scavenger less than 10 years ago...
  18. pmc Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night
    David E Blask
    Laboratory of Chrono Neuroendocrine Oncology, Tulane University School of Medicine, New Orleans, LA, USA
    J Pineal Res 51:259-69. 2011
    This review article discusses recent work on the melatonin-mediated circadian regulation and integration of molecular, dietary, and metabolic signaling mechanisms involved in human breast cancer growth and the consequences of circadian ..
  19. ncbi Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling
    Dingbo Shi
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    J Pineal Res 53:154-65. 2012
    b>Melatonin is an indoleamine secreted by the pineal gland as well as a plant-derived product that exerts potential anti-inflammatory properties, but the mechanisms of action remain unclear...
  20. ncbi Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells
    Mi Zhen Xia
    Life Science College, Anhui Agricultural University, Hefei, China
    J Pineal Res 53:325-34. 2012
    Increasing evidence demonstrates that melatonin has an anti-inflammatory effect. Nevertheless, the molecular mechanisms remain obscure...
  21. ncbi The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives
    Russel J Reiter
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, USA
    Mini Rev Med Chem 13:373-84. 2013
    b>Melatonin is an uncommonly widely distributed molecule. It is found throughout the plant and animal kingdoms, i.e., perhaps in every living organism...
  22. ncbi Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes
    Dun Xian Tan
    Department of Cellular and Structural Biology, The University of Texas, Health Science Center, San Antonio, TX 78229, USA
    J Pineal Res 54:127-38. 2013
    ..Because of this, these organelles require strong protection from free radicals and associated oxidative stress. Melatonin is a potent free radical scavenger and antioxidant...
  23. ncbi Intracellular signaling pathways involved in the cell growth inhibition of glioma cells by melatonin
    Vanesa Martin
    Departamento de Morfologia y Biologia Celular, Facultad de Medicina de la Universidad de Oviedo, Calle Julian Claveria, 33006 Oviedo, Spain
    Cancer Res 66:1081-8. 2006
    b>Melatonin is an indolamine mostly produced in the pineal gland, soluble in water, and highly lipophilic, which allows it to readily cross the blood-brain barrier...
  24. ncbi Melatonin: potential functions in the oral cavity
    Antonio Cutando
    Department of Special Care in Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Periodontol 78:1094-102. 2007
    b>Melatonin is synthesized and secreted by the pineal gland and other organs...
  25. ncbi Melatonin: a pleiotropic molecule regulating inflammation
    Flavia Radogna
    Dipartimento di Biologia, Universita di Roma Tor Vergata, Italy
    Biochem Pharmacol 80:1844-52. 2010
    b>Melatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions. Melatonin also regulates inflammatory and immune processes acting as both an activator and inhibitor of these responses...
  26. ncbi Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters
    Valerie Simonneaux
    Laboratoire de Neurobiologie Rythmes, UMR 7518 CNRS ULP, 12, rue de l université, 67000 Strasbourg, France
    Pharmacol Rev 55:325-95. 2003
    b>Melatonin, the major hormone produced by the pineal gland, displays characteristic daily and seasonal patterns of secretion...
  27. ncbi Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor
    G C Brainard
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neurosci 21:6405-12. 2001
    ..The aim of this study was to establish an action spectrum for light-induced melatonin suppression that could help elucidate the ocular photoreceptor system for regulating the human pineal gland...
  28. ncbi Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA
    Crit Rev Biochem Mol Biol 44:175-200. 2009
    The discovery of melatonin and its derivatives as antioxidants has stimulated a very large number of studies which have, virtually uniformly, documented the ability of these molecules to detoxify harmful reactants and reduce molecular ..
  29. pmc An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans
    K Thapan
    Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
    J Physiol 535:261-7. 2001
    ..responses mediated by the human eye include synchronisation of the circadian axis and suppression of pineal melatonin production. The retinal photopigment(s) transducing these light responses in humans have not been characterised...
  30. ncbi Ancestral TSH mechanism signals summer in a photoperiodic mammal
    Elodie A Hanon
    School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland
    Curr Biol 18:1147-52. 2008
    In mammals, day-length-sensitive (photoperiodic) seasonal breeding cycles depend on the pineal hormone melatonin, which modulates secretion of reproductive hormones by the anterior pituitary gland [1]...
  31. ncbi Arylalkylamine N-acetyltransferase: "the Timezyme"
    David C Klein
    Section on Neuroendocrinology, Office of Scientific Director, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:4233-7. 2007
    Arylalkylamine N-acetyltransferase controls daily changes in melatonin production by the pineal gland and thereby plays a unique role in biological timing in vertebrates...
  32. ncbi Melatonin: signaling mechanisms of a pleiotropic agent
    Rudiger Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    Biofactors 35:183-92. 2009
    b>Melatonin acts both as a hormone of the pineal gland and as a local regulator molecule in various tissues. Quantities of total tissue melatonin exceed those released from the pineal...
  33. pmc Melatonin: an underappreciated player in retinal physiology and pathophysiology
    Gianluca Tosini
    Circadian Rhythms and Sleep Disorders Program, Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Exp Eye Res 103:82-9. 2012
    In the vertebrate retina, melatonin is synthesized by the photoreceptors with high levels of melatonin at night and lower levels during the day...
  34. ncbi Melatonin blocks oxidative stress-induced increased asymmetric dimethylarginine
    You Lin Tain
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
    Free Radic Biol Med 49:1088-98. 2010
    ..were associated with oxidative stress in young bile-duct-ligation (BDL) rats; these increases were prevented by melatonin therapy...
  35. ncbi Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity
    D X Tan
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Obes Rev 12:167-88. 2011
    ..The physiology of BAT is readily regulated by melatonin, which not only increases recruitment of brown adipocytes but also elevates their metabolic activity in mammals...
  36. pmc MicroRNAs in the pineal gland: miR-483 regulates melatonin synthesis by targeting arylalkylamine N-acetyltransferase
    Samuel J H Clokie
    Section on Neuroendocrinology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:25312-24. 2012
    ..for the first time, and their importance was evaluated by focusing on the main function of the pineal gland, melatonin synthesis...
  37. ncbi Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model
    Zhong Wang
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
    J Pineal Res 53:129-37. 2012
    b>Melatonin has beneficial effects against early brain injury (EBI) by modulating cerebral oxidative stress after experimental subarachnoid hemorrhage (SAH); however, few investigations relate to the precise underlying molecular mechanisms...
  38. ncbi Gene regulation by melatonin linked to epigenetic phenomena
    Ahmet Korkmaz
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229 3900, USA
    Gene 503:1-11. 2012
    ..Both endogenous and pharmacological concentrations of melatonin have long been known to play role in the direct scavenging of ROS and RNS as well as inducing antioxidant ..
  39. pmc Melatonin secretion and the incidence of type 2 diabetes
    Ciaran J McMullan
    Renal Division, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    JAMA 309:1388-96. 2013
    Loss-of-function mutations in the melatonin receptor are associated with insulin resistance and type 2 diabetes...
  40. pmc The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity
    Xin Wang
    Neuroapoptosis Laboratory and Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 31:14496-507. 2011
    b>Melatonin mediates neuroprotection in several experimental models of neurodegeneration. It is not yet known, however, whether melatonin provides neuroprotection in genetic models of Huntington's disease (HD)...
  41. ncbi Melatonin suppresses tumor angiogenesis by inhibiting HIF-1alpha stabilization under hypoxia
    Shi Young Park
    Department of Molecular Biology, College of Natural Science, Pusan National University, Busan, Korea
    J Pineal Res 48:178-84. 2010
    ..In this study, we found that melatonin, a small lipophilic molecule secreted primarily by the pineal gland, destabilizes hypoxia-induced HIF-1alpha ..
  42. ncbi Molecular pathways involved in seasonal body weight and reproductive responses governed by melatonin
    Perry Barrett
    Rowett Institute for Nutrition and Health, University of Aberdeen, Aberdeen, UK
    J Pineal Res 52:376-88. 2012
    ..Daylength is encoded as the duration of production of the pineal hormone melatonin, but how the melatonin signal is decoded has been elusive...
  43. ncbi Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats
    You Lin Tain
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, College of Medicine, Taiwan
    J Pineal Res 49:390-8. 2010
    Nitric oxide (NO) deficiency is associated with development of hypertension. We examined whether melatonin protects against the blood pressure increase is because of the restoration of the NO pathway...
  44. ncbi Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cell Cycle 9:188-97. 2010
    ..Here we demonstrated that a combination of metformin and melatonin significantly inhibits growth of transplanted tumors in mice. Metformin (0...
  45. ncbi Melatonin in diseases of the oral cavity
    G Gomez-Moreno
    School of Dentistry, University of Granada, Granada, Spain
    Oral Dis 16:242-7. 2010
    b>Melatonin is the principal secretory product of the pineal gland...
  46. pmc Involvement of thyrotropin in photoperiodic signal transduction in mice
    Hiroko Ono
    Laboratory of Animal Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 105:18238-42. 2008
    ..In mammals, nocturnal melatonin secretion provides an endocrine signal of the photoperiod to the PT that contains melatonin receptors in high ..
  47. ncbi Melatonin in humans
    A Brzezinski
    Department of Obstetrics and Gynecology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    N Engl J Med 336:186-95. 1997
  48. ncbi A molecular switch for photoperiod responsiveness in mammals
    Hugues Dardente
    Institute of Biological and Environmental Sciences, Zoology Building, Tillydrone Avenue, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Curr Biol 20:2193-8. 2010
    ..The pineal hormone melatonin, secreted nocturnally, sets the phase of rhythmic Eya3 expression in the PT to peak 12 hr after nightfall...
  49. ncbi Melatonin: Nature's most versatile biological signal?
    S R Pandi-Perumal
    Comprehensive Center for Sleep Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    FEBS J 273:2813-38. 2006
    b>Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals...
  50. ncbi Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways
    Seithikurippu R Pandi-Perumal
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, Room BB813, NY 10032, USA
    Prog Neurobiol 85:335-53. 2008
    b>Melatonin, an endogenous signal of darkness, is an important component of the body's internal time-keeping system...
  51. ncbi Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114
    Neuron 13:1177-85. 1994
    The pineal hormone melatonin regulates seasonal reproductive function and modulates circadian rhythms in mammals. We now report the cloning and characterization of a high affinity receptor for melatonin from the sheep and human...
  52. ncbi Melatonin and associated signaling pathways that control normal breast epithelium and breast cancer
    Steven M Hill
    Department of Structural and Cellular Biology, Tulane University School of Medicine, 1430 Tulane Avenue, SL 49, New Orleans, LA 70112, USA
    J Mammary Gland Biol Neoplasia 16:235-45. 2011
    This review article discusses recent work on the melatonin-mediated circadian regulation and integration of molecular and metabolic signaling mechanisms involved in human breast cancer growth and the associated consequences of circadian ..
  53. pmc Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review
    Robert L Sack
    Department of Psychiatry, Oregon Health Sciences University, Portland, OR, USA
    Sleep 30:1484-501. 2007
    ..We herein report on the accumulated evidence regarding the evaluation and treatment of Advamced Sleep Phase Disorder (ASPD), Delayed Sleep Phase Disorder (DSPD), Free-Running Disorder (FRD) and Irregular Sleep-Wake Rhythm ISWR)...
  54. ncbi Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder
    Bruno Etain
    Psychiatrie Génétique, INSERM U 955, Creteil 94000, France
    Hum Mol Genet 21:4030-7. 2012
    ..In addition, they showed abnormal oscillating melatonin secretion, a key regulator of circadian rhythms and sleep patterns...
  55. ncbi Melatonin inhibits IL1β-induced MMP9 expression and activity in human umbilical vein endothelial cells by suppressing NF-κB activation
    Weiwei Qin
    Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China
    J Endocrinol 214:145-53. 2012
    ..The purpose of this study was to investigate the protective effect of melatonin in human umbilical vein endothelial cell (HUVEC) monolayer permeability and the regulation of MMP9 induced by ..
  56. ncbi Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade
    Nicholas M Radio
    Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    J Pineal Res 40:332-42. 2006
    The goals of this study were to determine (a) if melatonin enhances human adult mesenchymal stem cell (hAMSC) differentiation into osteoblasts as assessed by measuring alkaline phosphatase (ALP) enzyme activity, and (b) identify ..
  57. ncbi Maternally administered melatonin differentially regulates lipopolysaccharide-induced proinflammatory and anti-inflammatory cytokines in maternal serum, amniotic fluid, fetal liver, and fetal brain
    De Xiang Xu
    Department of Toxicology, Anhui Medical University, Hefei, China
    J Pineal Res 43:74-9. 2007
    ..b>Melatonin is an immunomodulator...
  58. ncbi Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science
    Dun Xian Tan
    Department of Cellular and Structural Biology, The University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl, San Antonio, TX 78229, USA
    J Exp Bot 63:577-97. 2012
    The presence of melatonin in plants is universal...
  59. pmc Timed maternal melatonin treatment reverses circadian disruption of the fetal adrenal clock imposed by exposure to constant light
    Natalia Méndez
    Instituto de Anatomia, Histologia y Patologia, Universidad Austral de Chile, Valdivia, Chile
    PLoS ONE 7:e42713. 2012
    ..Our hypothesis is that the maternal plasma melatonin rhythm drives the fetal circadian system, which in turn relies this information to other fetal tissues through ..
  60. ncbi Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model
    Nicola J Robertson
    Institute for Women s Health, University College London, 74 Huntley Street, London WC1E 6AU, UK
    Brain 136:90-105. 2013
    ..Additional treatments are required to maximize neuroprotection. Melatonin is a naturally occurring hormone involved in physiological processes that also has neuroprotective actions ..
  61. ncbi Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials
    Farhanah Yousaf
    Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 113:968-76. 2010
    b>Melatonin possesses sedative, hypnotic, analgesic, antiinflammatory, antioxidative, and chronobiotic properties that distinguish it as an attractive alternative premedicant...
  62. ncbi Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury
    Hon Kan Yip
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Pineal Res 54:207-21. 2013
    This study investigated whether melatonin-treated adipose-derived mesenchymal stem cells (ADMSC) offered superior protection against acute lung ischemia-reperfusion (IR) injury...
  63. ncbi Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis
    Lena Melamud
    Division of Neuroimmunology and Multiple Sclerosis Center, Carmel Medical Center, Haifa, Israel
    J Neurol Sci 314:37-40. 2012
    Sleep disruption and fatigue are common in Multiple Sclerosis (MS). Melatonin is one of the major regulators of sleep-wake cycle...
  64. ncbi Melatonin induces Cry1 expression in the pars tuberalis of the rat
    Hugues Dardente
    Neurobiologie des Rythmes, UMR 7518 CNRS ULP, IFR 37, 12, rue de l université, 67000 Strasbourg, France
    Brain Res Mol Brain Res 114:101-6. 2003
    ..The peak of Cry1 mRNA expression occurs during the night concomitantly with rising blood plasma melatonin concentrations...
  65. ncbi Urinary melatonin levels and breast cancer risk
    Eva S Schernhammer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:1084-7. 2005
    Exposure to light at night suppresses melatonin production, and night-shift work (a surrogate for such exposure) has been associated with an increased risk of breast cancer...
  66. ncbi Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia
    Ming Wai Hung
    Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Pineal Res 44:214-21. 2008
    ..We evaluated the hypothesis that melatonin would reduce IH-induced hippocampal injury via an increased expression of antioxidant enzymes...
  67. ncbi Melatonin modulates the expression of VEGF and HIF-1 alpha induced by CoCl2 in cultured cancer cells
    Min Dai
    Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    J Pineal Res 44:121-6. 2008
    b>Melatonin is an important natural oncostatic agent. At present there are no data available as to its possible influence on tumor angiogenesis, which is a major biological mechanism responsible for tumor growth and dissemination...
  68. ncbi Molecular pharmacology, regulation and function of mammalian melatonin receptors
    Margarita L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Front Biosci 8:d1093-108. 2003
    b>Melatonin (5-methoxy-N-acetyltryptamine), dubbed the hormone of darkness, is released following a circadian rhythm with high levels at night...
  69. ncbi The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans
    Nayantara Santhi
    Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
    J Pineal Res 53:47-59. 2012
    ..The evening rise of melatonin, sleepiness and EEG-assessed sleep onset varied significantly (P<0...
  70. ncbi Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy
    Hans G Richter
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Pineal Res 46:357-64. 2009
    b>Melatonin participates in circadian, seasonal and reproductive physiology. Melatonin also acts as a potent endogenous antioxidant by scavenging free radicals and upregulating antioxidant pathways...
  71. ncbi High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    J Clin Endocrinol Metab 90:1311-6. 2005
    ..Exposure to 2 h of monochromatic light at 460 nm in the late evening induced a significantly greater melatonin suppression than occurred with 550-nm monochromatic light, concomitant with a significantly greater alerting ..
  72. pmc Abnormal melatonin synthesis in autism spectrum disorders
    J Melke
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Mol Psychiatry 13:90-8. 2008
    b>Melatonin is produced in the dark by the pineal gland and is a key regulator of circadian and seasonal rhythms...
  73. ncbi Role of melatonin in upper gastrointestinal tract
    S J Konturek
    Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, Cracow, Poland
    J Physiol Pharmacol 58:23-52. 2007
    b>Melatonin, an indole formed enzymatically from L-tryptophan, is the most versatile and ubiquitous hormone molecule produced not only in all animals but also in some plants...
  74. ncbi Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine, Avda Sanchez Pizjuan 4, 41009 Seville, Spain
    FASEB J 18:537-9. 2004
    It has been historically assumed that the pineal gland is the major source of melatonin (N-acetyl-5-methoxytryptamine) in vertebrates. Melatonin plays a central role in fine-tuning circadian rhythms in vertebrate physiology...
  75. pmc Plasma melatonin circadian rhythm disturbances during pregnancy and postpartum in depressed women and women with personal or family histories of depression
    Barbara L Parry
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 165:1551-8. 2008
    The purpose of this study was to test the hypothesis that disturbances in levels of plasma melatonin differentiate pregnant and postpartum women with major depression from matched pregnant and postpartum healthy comparison women.
  76. ncbi Novel melatonin-based therapies: potential advances in the treatment of major depression
    Ian B Hickie
    Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW, Australia
    Lancet 378:621-31. 2011
    ..In particular, we highlight agomelatine, a melatonin-receptor agonist and selective serotonergic receptor subtype (ie, 5-HT(2C)) antagonist that has chronobiotic, ..
  77. ncbi Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies
    Michael Wilhelmsen
    Department of Surgical Gastroenterology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    J Pineal Res 51:270-7. 2011
    b>Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties...
  78. pmc The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis (AIS)
    M Girardo
    Department of Spine Surgery, CTO CRF Maria Adelaide, Turin, Italy
    Eur Spine J 20:S68-74. 2011
    ..Reported associations are linked in pathogenesis rather than etiologic factors. Melatonin may play a role in the pathogenesis of scoliosis (neuroendocrine hypothesis), but at present, the data available ..
  79. ncbi Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin
    Charlotte Von Gall
    Institute of Anatomy II, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Nat Neurosci 5:234-8. 2002
    ..the heterologous sensitization of the adenosine A2b receptor, which occurs through the nocturnal activation of melatonin mt1 receptors...
  80. ncbi Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report
    D Warren Spence
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    J Neuropsychiatry Clin Neurosci 16:19-28. 2004
    ..002) nocturnal increase in endogenous melatonin secretion (as measured in urine) and significant improvements in polysomnographic measures of sleep onset ..
  81. ncbi Ca2+/calmodulin-dependent protein kinase II-dependent long-term potentiation in the rat suprachiasmatic nucleus and its inhibition by melatonin
    Kohji Fukunaga
    Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto, Japan
    J Neurosci Res 70:799-807. 2002
    ..Interestingly, treatment with melatonin totally prevented LTP induction, without changes in basal synaptic transmission...
  82. ncbi Melatonin-immune system relationships
    Juan M Guerrero
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Spain
    Curr Top Med Chem 2:167-79. 2002
    In this paper we review the historical milestones that first highlighted the existence of a relationship between melatonin and the immune system and we summarize data from experiments which correlate the rhythmic production of melatonin ..
  83. pmc Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 92:8734-8. 1995
    A G protein-coupled receptor for the pineal hormone melatonin was recently cloned from mammals and designated the Mel1a melatonin receptor...
  84. pmc A phase response curve to single bright light pulses in human subjects
    Sat Bir S Khalsa
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 549:945-52. 2003
    ..Light exposures were scheduled across the circadian cycle in different subjects so as to derive a PRC. Plasma melatonin was used to determine the phase of the onset, offset, and midpoint of the melatonin profiles during the CRs...
  85. ncbi Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance
    Rudiger Hardeland
    Institute of Zoology, Anthropology and Developmental Biology, University of Gottingen, Gottingen, Germany
    Endocrine 27:119-30. 2005
    b>Melatonin has been shown to protect against oxidative stress in various, highly divergent experimental systems. There are many reasons for its remarkable protective potential...
  86. ncbi The glutathione system and its regulation by neurohormone melatonin in the central nervous system
    Jorge H Limón-Pacheco
    Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Boulevard Juriquilla 3001, Queretaro, Mexico
    Cent Nerv Syst Agents Med Chem 10:287-97. 2010
    ..The administration of exogenous neurohormone melatonin at pharmacological doses has been shown not only to be an effective scavenger of reactive oxygen and nitrogen ..
  87. ncbi Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations
    Carmen Venegas
    Instituto de Biotecnologia, Centro de Investigacion Biomedica, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain
    J Pineal Res 52:217-27. 2012
    We studied the subcellular levels of melatonin in cerebral cortex and liver of rats under several conditions...
  88. ncbi Melatonin stimulates osteointegration of dental implants
    Antonio Cutando
    Department of Special Care in Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Pineal Res 45:174-9. 2008
    The aim of this study was to evaluate the effect of the topical application of melatonin on osteointegration of dental implants in Beagle dogs 14 days after their insertion...
  89. ncbi Melatonin transmits photoperiodic signals through the MT1 melatonin receptor
    Shinobu Yasuo
    Dr Senckenbergische Anatomie, Institute of Anatomie II, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany
    J Neurosci 29:2885-9. 2009
    b>Melatonin transmits photoperiodic signals that regulate reproduction...
  90. ncbi ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells
    F Luchetti
    Institute of Morphological Sciences, University of Urbino Carlo Bo, Urbino, Italy
    Free Radic Biol Med 46:339-51. 2009
    The pineal gland hormone melatonin has been recently described to downregulate the intrinsic (or damage-induced) pathway of apoptosis in human leukocytes...
  91. ncbi RFamide-related peptide gene is a melatonin-driven photoperiodic gene
    Florent G Revel
    Département de Neurobiologie des Rythmes, Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Integratives, Université Louis Pasteur Institut Fédératif de Recherche des Neurosciences, Strasbourg, France
    Endocrinology 149:902-12. 2008
    In seasonal species, various physiological processes including reproduction are organized by photoperiod via melatonin, but the mechanisms of melatonin action are still unknown...
  92. ncbi Antioxidative potential of melatonin against mercury induced intoxication in spermatozoa in vitro
    Mandava V Rao
    Reproductive Physiology and Toxicology Unit, Department of Zoology and Bio Medical Technology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380 009, India
    Toxicol In Vitro 22:935-42. 2008
    ..Considering the antioxidant properties of melatonin, this study was aimed to evaluate the effect of melatonin on antioxidant system of rat epididymal sperm in vitro...
  93. pmc Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans
    Joshua J Gooley
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 96:E463-72. 2011
    Millions of individuals habitually expose themselves to room light in the hours before bedtime, yet the effects of this behavior on melatonin signaling are not well recognized.
  94. ncbi Chemoprotective effect of melatonin against cisplatin-induced testicular toxicity in rats
    Ahmet Atessahin
    Department of Pharmacology and Toxicology, Faculty of Medicine, Firat University, Elazig, Turkey
    J Pineal Res 41:21-7. 2006
    In this study, we investigated the effect of melatonin on cisplatin-induced spermiotoxicity using quantitative, biochemical and histopathological approaches...
  95. ncbi Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus
    Vishwajit S Chowdhury
    Laboratory of Integrative Brain Sciences, Department of Biology, Waseda University, Center for Medical Life Science of Waseda University, 2 2 Wakamatsu cho, Shinjuku ku, Tokyo 162 8480, Japan
    Endocrinology 151:271-80. 2010
    ..In addition, GnIH neurons express melatonin receptor and melatonin induces GnIH expression in the quail brain...
  96. ncbi Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines
    T W Fischer
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, 38163, USA
    Int J Oncol 29:665-72. 2006
    b>Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo...
  97. ncbi Physiology and pharmacology of melatonin in relation to biological rhythms
    Jolanta B Zawilska
    Department of Pharmacodynamics, Medical University of Łódź, Muszynskiego 1, PL 90 151 Łódź, Poland
    Pharmacol Rep 61:383-410. 2009
    b>Melatonin is an evolutionarily conserved molecule that serves a time-keeping function in various species...
  98. pmc Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process
    Aaron Mickle
    Division of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pain 149:555-64. 2010
    Previous reports suggest that melatonin may play an important role in visceral nociception and neurogenic inflammation...
  99. ncbi Absence of melatonin induces night-time hepatic insulin resistance and increased gluconeogenesis due to stimulation of nocturnal unfolded protein response
    Tatiane C Nogueira
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508 900, Brazil
    Endocrinology 152:1253-63. 2011
    ..However, increased glycemia and reduced melatonin (Mel) levels have been recently shown to coexist in diabetic patients at the end of the night period...
  100. ncbi Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)
    Anna Leja-Szpak
    Faculty of Health Sciences, Department of Medical Physiology, Jagiellonian University School of Medicine, Krakow, Poland
    J Pineal Res 49:248-55. 2010
    ..It responds poorly to radio- and chemotherapy because the tumor cells are resistant to apoptosis. Melatonin has been reported to inhibit pancreatic cancer growth in experimental studies in animals but the effect of ..
  101. ncbi Medical implications of melatonin: receptor-mediated and receptor-independent actions
    R J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Adv Med Sci 52:11-28. 2007
    The functional versatility and diversity of melatonin has exceeded everyone's expectations. The evidence is substantial that melatonin has multiple receptor-mediated and receptor-independent actions...

Research Grants76

  1. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..Corticotrophin releasing hormone (CRH) and melatonin can accelerate arthritis, and although the SNS can increase CRH and melatonin or their role is unknown in ..
  2. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ..decrease apical CA1 spine density and increase basilar CA3 spine density suggesting that photoperiod, encoded by melatonin, alters brain structure and cognitive function...
  3. The Role of Circadian Periodicity in Human Cardiovascular Disease and Diabetes
    John P Forman; Fiscal Year: 2013
    ..b>Melatonin is a hormone secreted by the pineal gland (under the control of the suprachiasmatic nucleus) and entrained to ..
  4. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..Finally we will use hormone manipulations and real-time PCR to test whether melatonin inhibits estrogen-dependent gene expression in the brain, thereby blocking genomic action in short-day mice...
  5. Discovery of Selective MT1 Melatonin Receptor Ligands for Sleep Disorders
    Margarita L Dubocovich; Fiscal Year: 2010
    ..b>Melatonin, a neurohormone secreted in a circadian fashion by the pineal gland, promotes sleep and regulates circadian ..
  6. Role of exogenous melatonin in skin biology
    Andrzej T Slominski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): It was assumed that in vertebrates melatonin is only produced in the pineal gland and retina...
  7. Novel CNS Target for Sleep-Wake and Psychiatric Disorders
    SCOTT MCNEAR THACHER; Fiscal Year: 2010
    ..b>Melatonin and its analogues, which have soporific as well as circadian phase-shifting effects, are not widely used in ..
  8. Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure
    Nancy S Redeker; Fiscal Year: 2010
    ..We will also obtain day and night measures of urinary free cortisol, free epinephrine/norepinephrine, and melatonin sulfate...
  9. Mechanisms of Functional Recovery After Partial Nerve Injury
    Michael M Wang; Fiscal Year: 2012
    ..Normally, the bilateral superior cervical ganglia (SCG) both innervate the pineal gland to stimulate nightly melatonin synthesis...
  10. Seasonality of Mood: A Genome-Wide Association Study in the Old Order Amish
    Teodor T Postolache; Fiscal Year: 2010
    ..of timed bright light exposure in treating SAD27-30, and an extended duration in winter of nocturnal melatonin secretion in SAD patients (but not in controls) as in photoperiodic mammals1 A previous twin study on ..
  11. Melatonin in Menopausal Depression
    Barbara L Parry; Fiscal Year: 2012
    ..We have observed increased melatonin secretion and delayed morning offset in menopausal depressed patients (DP) compared with normal control (NC) ..
  12. Circadian rhythm genes and sleep disturbances in the elderly
    Gregory J Tranah; Fiscal Year: 2010
    ..Our specific aims are to test common genetic variants and haplotypes in 21 circadian rhythm and 4 melatonin metabolism genes for association with rest activity rhythms and sleep characteristics as measured by actigraphy, ..
  13. Circadian Clock Function in the Mammalian Retina
    Christophe P Ribelayga; Fiscal Year: 2013
    ..By interacting with the dopamine and melatonin neuromodulator systems that are involved in light/dark adaptation, the retinal clock provides a mechanism to ..
  14. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina V Zhdanova; Fiscal Year: 2013
    ..period, which established a reciprocal relationship between the cocaine and zebrafish clock system, found that melatonin can counteract the effects of cocaine on brain development, identified two strains with contrasting effects of ..
  15. Registry Study of Parkinsons Disease in Denmark
    Beate R Ritz; Fiscal Year: 2010
    ..and greenhouse occupations (pesticides), metal related industries (metals and solvents), and night shift work (melatonin levels);2) whether certain drugs and medical conditions are positively or inversely associated with PD (e.g...
  16. Gut Circadian Clock and Melatonin Dynamics Following Major Thermal Injury
    Walid M Al Ghoul; Fiscal Year: 2013
    ..in gut mucosa barrier milieu with spatiotemporally-intersecting molecular circadian clock and de novo gut melatonin production dynamics on days 1, 3 and 7 following major thermal injury...
  17. Electric Studies of Excitation, Secretion &Contraction
    Bertil Hille; Fiscal Year: 2013
    ..It is the part of our circadian clock system that broadcasts the night hormone, melatonin, to all of the body...
  18. Circadian rhythms and melatonin signaling in the aging gastrointestinal system
    Vincent M Cassone; Fiscal Year: 2013
    ..that one factor mediating changes in intestinal function during aging is the circadian secretion of the hormone melatonin by the pineal gland and by intestinal tissues themselves...
  19. Regulation of Bile Duct Growth in Bile Duct Ligated Rats
    SHANNON STROUD GLASER; Fiscal Year: 2013
    ..is to determine the molecular mechanisms by which local (from cholangiocytes), paracrine (by administration of melatonin or anti-melatonin antibody) and central (from pineal gland) melatonin synthesis (regulated by the enzyme AANAT ..
  20. The Role of Melatonin in Natural Neuroprotection
    Christine Schwartz; Fiscal Year: 2013
    ..Additionally, production of the neuroprotective hormone melatonin accompanies arousal, suggesting that it plays a protective role at this time, when the squirrels are susceptible ..
  21. Human circadian sensitivity to very short light pulses
    Elizabeth B Klerman; Fiscal Year: 2010
    ..Other non-visual effects of ocular light exposure include melatonin suppression (signal for seasonal reproductive changes), pupillary reflexes, and changes in heart rate, ..
  22. Circuitry for circadian rhythms
    Clifford B Saper; Fiscal Year: 2013
    ..circuitry that underlies circadian timing of wake-sleep, feeding, activity, body temperature, and secretion of melatonin and corticosteroids...
  23. Malaria melatonin receptor signaling as a novel drug target
    Andrew P Thomas; Fiscal Year: 2013
    ..The proposed target is a malarial melatonin receptor (pMTR) that is postulated to subvert the host hormone melatonin to regulate parasite proliferation and ..
  24. Impact of MTNR1B and CRY2 variants on sleep circadian physiology and metabolism
    Frank A Scheer; Fiscal Year: 2011
    ..Interestingly, two newly discovered T2D risk variants are located in the melatonin receptor gene MTNR1B and in the core circadian clock gene CRY2, providing compelling and converging support that ..
  25. Sleep and biological rhythms after fetal exposure to antidepressants
    Amy L Salisbury; Fiscal Year: 2013
    ..SRI or MDD exposure on sleep-state organization, 24-hour sleep-wake rhythms, and diurnal urinary excretion of melatonin sulfate, cortisol, epinephrine, and norepinephrine...
  26. Home sleep and circadian phase: mediators of racial disparities in diabetes risk
    Kristen Knutson; Fiscal Year: 2013
    ..sleep durations alter circadian phase, (2) circadian disruption produces metabolic disturbances, and (3) the melatonin rhythm directly impacts beta-cell function, circadian disruption has not previously been considered as a key ..
  27. Prospective Assessment of The Etiology of Insomnia in Middle Aged &Elder Adults
    MICHAEL LLOYD PERLIS; Fiscal Year: 2013
    ..will include two nights of polysomnography, the collection of urine samples at each void (to assess cortisol and melatonin levels), and the administration of an attention bias test regimen...
  28. DIETARY AND HORMONAL DETERMINANTS OF CANCER IN WOMEN
    Meir Stampfer; Fiscal Year: 2013
    ..Cross-cutting themes include the investigation of vitamin D and melatonin, energy balance and inflammatory pathways, as well as the examination of fatal outcomes and the molecular ..
  29. Effects of the circadian clock and light on the production of estrogens
    Steven W Lockley; Fiscal Year: 2010
    ..Several candidate mechanisms have been proposed. One hypothesis states that that the pineal hormone melatonin plays a key role in shift workers'cancer risk...
  30. 2012 Pineal Cell Biology Gordon Research ConferenceLinks to circadian clocks, sl
    Vincent M Cassone; Fiscal Year: 2011
    ..our understanding of the molecular networks and biochemical pathways linking the pineal gland and its hormone melatonin with the circadian clock timing system, sleep/wake processing and metabolism...
  31. FASEB SRC on Melatonin Receptors: Actions and Therapeutics
    David Blask; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The 2011 conference will focus on the role of melatonin receptors as potential therapeutic targets in depression, autism spectrum disorders, drug-induced behavioral sensitization, neurodegenerative ..
  32. Dissecting Pathways of Circadian Disruption in Major Depressive Disorder
    Nicole M Edgar; Fiscal Year: 2013
    ..the pathophysiology of major depressive disorder (MDD) and treatments modulating circadian rhythms, such as the melatonin receptor agonist agomelatine, have been shown to be successful treatments for MDD...
  33. Biological Rhythms and Immune Function
    Brian J Prendergast; Fiscal Year: 2013
    ..responses in experiments that seek to: (1) identify the cellular mechanisms by which changes in day length and melatonin control immune cell activity, (2) specify the role of thyroid hormone signaling in the genesis of seasonal ..
  34. 2010 Pineal Cell Biology Gordon Research Conference
    DAVID RAYMOND WEAVER; Fiscal Year: 2010
    ..and cellular function of the pineal gland, of how the rhythmic synthesis and release of the pineal hormone melatonin contributes to vertebrate physiology, and the importance of circadian rhythms in physiological functions and ..
  35. Circadian Timing, Sleep, and Adiposity
    Kelly Glazer Baron; Fiscal Year: 2013
    ..It is Dr. Baron's hope that this work will lead to interventions to prevent and treat obesity through new mechanisms, such as shifting circadian rhythms using behavioral changes, light and melatonin.
  36. Human circadian, sleep, cardiovascular and neurobehavioral responses to light
    Elizabeth B Klerman; Fiscal Year: 2013
    ..Other non-visual effects of ocular light exposure include melatonin suppression (as a signal for seasonal reproductive changes), pupillary reflexes, and changes in heart rate, ..
  37. Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease
    Aleksandar Videnovic; Fiscal Year: 2013
    ..g., melatonin, clock genes and the rest-activity cycle)...
  38. Circadian Organization of the Retina
    Douglas G McMahon; Fiscal Year: 2013
    ..through rhythmic gene expression and rhythmic of release of modulatory neurotransmitters such as dopamine and melatonin. Although the retinal circadian clock exerts extensive influence over retinal physiology and metabolism, the ..
  39. Effects of Sleep Deprivation on Infection Induced Organ Failure
    Leigh A Callahan; Fiscal Year: 2013
    ..ATAD-fmk (a caspase 12 inhibitor), salubrinal (a selective inhibitor of eIF2[unreadable] dephosphorylation), or melatonin (an endogenous hormone that inhibits the IRE1[unreadable] pathway) will block ER stress pathway dependent cell ..
  40. Mechanisms that regulate zebrafish Hypocretin neuron development and function
    DAVID AARON PROBER; Fiscal Year: 2013
    ..Third, we will determine whether other sleep regulators, including adenosine, melatonin, and Kv3-type potassium channels, affect sleep via the Hcrt system...
  41. Sleep Length and Circadian Regulation in Humans
    HELEN JULIA BURGESS; Fiscal Year: 2012
    ..We will estimate the timing of the human circadian clock by measuring salivary melatonin, a neuroendocrine hormone released from the pineal gland, and collecting measures of sleep via actigraphy, and ..
  42. Individually tailored lighting system to improve sleep in older adults
    MARIANA FIGUEIRO; Fiscal Year: 2013
    ..light delivered through the eyelids before predicted minimum core body temperature (CBTmin) acutely suppressed melatonin and delayed dim light melatonin onset (DLMO)...
  43. Risk Factors for Breast Cancer in Younger Nurses
    Walter C Willett; Fiscal Year: 2013
    ..we have seen with high school and premenopausal adult diet, adolescent physical activity, shift work, and melatonin secretion also influence risk of postmenopausal breast cancer...
  44. Circadian Phase Assessments at Home
    HELEN JULIA BURGESS; Fiscal Year: 2013
    ..master internal circadian clock is most reliably measured from the onset of the endogenous circadian rhythm of melatonin, a neuroendocrine hormone, as measured in dim light (dim light melatonin onset, or "DLMO")...
  45. Targeting Placental Pathophysiology in IUGR and Preeclampsia
    Seth Guller; Fiscal Year: 2010
    ..Importantly, we observed that treatment with glucocorticoid (GC), and the pineal gland peptide melatonin (MT), suppressed IL-!3 effects on cytokine expression in FIBs...
  46. Alcohol Alters the Circadian Response to Light in Humans
    HELEN JULIA BURGESS; Fiscal Year: 2013
    ..are abnormal and (2) test nonaddictive, affordable and accessible chronobiological treatments (evening exogenous melatonin and/or enhanced morning light exposure) to reduce circadian misalignment and improve health...
  47. Intrinsic Circadian Period: Development Delayed Phase and Genetic Associations
    Mary A Carskadon; Fiscal Year: 2012
    ..to live in the laboratory for 15 consecutive days and nights under specific testing conditions to measure sleep, melatonin secretion, mood, and performance...
  48. Efficacy of melatonin treatment in a phase advance model of insomnia
    Jeanne F Duffy; Fiscal Year: 2013
    b>Melatonin is a hormone produced by the pineal gland at night. The timing of its release is controlled by the circadian timing system...
  49. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2013
    ..Previous work has shown that melatonin acting via g protein- coupled melatonin receptors (MTRs) plays a key role in the regulation of a wide variety of ..
  50. Melatonin: pacemaker for nocturnal periodicity of microfilarial parasites
    JEFFERSON ARCHER VAUGHAN; Fiscal Year: 2012
    ..Hypothesis: The primary host cue that regulates mf periodicity is the bioactive amine, melatonin, which is secreted into the blood stream from the pineal gland at a regular, circadian periodicity...
  51. NEURONAL PLASTICITY IN THE RETINA
    Stuart C Mangel; Fiscal Year: 2012
    ..retinal clock uses the intracellular signaling molecules cyclic AMP and protein kinase A and the neuromodulators melatonin and adenosine, in addition to dopamine, to regulate rod and cone input to cone-connected horizontal cells and to ..
  52. Contribution of circadian rhythm and maternal entrainment to infant regulation
    Karen A Thomas; Fiscal Year: 2013
    ..influences (light, home routine) on entrainment of circadian rhythm as measured by maternal and infant salivary melatonin circadian rhythm assessed at 4, 8, and 12 weeks infant age...
  53. A Placebo Controlled Trial of L-Tryptophan in Post-Operative Delirium
    THOMAS NICHOLS ROBINSON; Fiscal Year: 2013
    ..Delirium will be assessed twice daily post-operatively. Biomarkers (tryptophan, serotonin and melatonin) will be measured pre- and post-operatively...
  54. Rotating Night Shifts, Sleep Duration, and the Risk of Colorectal Adenoma
    Esther Wei; Fiscal Year: 2013
    ..for this association is that exposure to artificial light during night hours leads to disrupted levels of melatonin and an increased risk of carcinogenesis. Colorectal cancer is the third most common cancer in the United States...
  55. The role of melatonin signaling in regulation of beta-cell survival and function
    Aleksey V Matveyenko; Fiscal Year: 2012
    ..Chris Colwell (co-mentor) and a distinguished investigator in circadian biology/melatonin signaling and Dr. Gene Block who is an authority in the study of biological circadian rhythms...
  56. Role of Circadian Misalignment in Beta-cell Failure in Type 2 Diabetes
    Aleksey V Matveyenko; Fiscal Year: 2013
    ..Lastly, in the third Specific Aim, studies will address the hypothesis that circadian hormone melatonin plays a previously underappreciated role in the regulation of beta cell function, survival and defense response ..
  57. Retinal circadian rhythms and refractive development
    RICHARD ALAN STONE; Fiscal Year: 2013
    ..Extensively studied, the retina has many intrinsic circadian rhythms (e.g., disc shedding, melatonin secretion), and it achieves circadian timing through interconnected feedback loops involving clock genes and ..
  58. Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies
    Lance R McMahon; Fiscal Year: 2010
    ..withdrawal signs will include a benzodiazepine (zolpidem or Ambien(), the 5HT2A antagonist M100907, and the melatonin agonist ramelteon (Rozerem()...
  59. N-Terminal Acetylation and Protein Degradation by the N-End Rule Pathway
    ALEXANDER J VARSHAVSKY; Fiscal Year: 2013
    ..Aanat produces Ac-serotonin, the immediate precursor of melatonin, a hormone that regulates circadian rhythm...
  60. Sleep, Circadian, Hormonal Dysregulation, and Breast Cancer Survival
    David Spiegel; Fiscal Year: 2010
    ..We will also examine sleep patterns in association with disrupted circadian rhythms of cortisol, CRF, ACTH, and melatonin as well as measures of immune function known to be salient to breast cancer progression...
  61. Circadian and Melatonin Pathway Genes in Breast Cancer Risk
    Sandra L Deming; Fiscal Year: 2010
    ..will expand our understanding of the relationships between genetic susceptibility related to circadian rhythms, melatonin pathways, and breast cancer risk...
  62. Minimizing Cancer Risk in Shift Workers
    Eva S Schernhammer; Fiscal Year: 2013
    ..shift work a probable carcinogen - the main operating mechanism being assumed circadian disruption by means of melatonin suppression...
  63. Melatonin Receptors as Therapeutic Targets in Primates
    Margarita Dubocovich; Fiscal Year: 2006
    The overall goal of our research is to understand the mechanism(s) by which melatonin regulates neuroendocrine, circadian, visual, and cardiovascular functions and to apply this knowledge to the design of new therapeutic strategies...
  64. PINEAL FUNCTION IN CHILDHOOD AND ADOLESCENCE
    Anita Cavallo; Fiscal Year: 1990
    ..Factors that now are known to affect melatonin concentrations (circadian and seasonal variations, cycles of light/dark and sleep/wake activity, body size, ..
  65. MELATONIN AND CEREBRAL BLOOD FLOW AUTOREGULATION
    Mohan Viswanathan; Fiscal Year: 2000
    b>Melatonin, a neuroendocrine transducer of photoperiod, is used by mammals to establish and maintain circadian rhythms. Melatonin receptors which mediate these functions are believed to be located in the hypothalamus...
  66. Retinal Circadian Signaling in a Transgenic Model
    Allan Wiechmann; Fiscal Year: 2004
    DESCRIPTION: (Applicant's Abstract) The neurohormone, melatonin, is a primary output signal of the circadian clock in retinal photoreceptors...
  67. ENVIRONMENTAL CONTROL OF SEASONAL WEIGHT CYCLES
    George Wade; Fiscal Year: 1992
    ..The effects of photoperiod on body weight are mediated by the pineal gland and its hormone, melatonin, Pinealectomized (PINX) hamsters typically do not respond to changes in photoperiod, and properly timed ..
  68. MOLECULAR NEUROBIOLOGY OF THE CIRCADIAN CLOCK
    Vincent Cassone; Fiscal Year: 2000
    ..the suprachiasmatic nucleus (SCN), the pineal gland and eyes, which influence circadian rhythms via the hormone melatonin. In birds, melatonin plays a particularly critical role...
  69. PHOTOPERIODIC CONTROL OF REPRODUCTION: EFFECTS OF AGE
    Fred Turek; Fiscal Year: 2001
    ..Both the circadian clock located in the hypothalamic suprachiasmatic nucleus and the pineal melatonin rhythm play a central role in relaying information about length of the day to the neuroendocrine-gonadal axis...
  70. LIGHT DURING DARKNESS AND BREAST CANCER PROGRESSION
    David Blask; Fiscal Year: 2004
    ..The pineal gland hormone melatonin, which inhibits experimental human breast cancer growth, is produced during darkness; light present during ..
  71. MELATONIN FOR SLEEP DISTURBANCES DURING MENOPAUSE
    Andrea Suhner; Fiscal Year: 2001
    ..which can adversely affect night-time sleep quality The proposed study will test the hypothesis that exogenous melatonin decreases LH levels and in so doing, increases sleep quality...
  72. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2002
    ..that mediates the influence of day length on seasonal reproductive physiology involves the circadian pineal melatonin rhythm, the major focus of the proposal is to test the hypothesis that the pineal melatonin rhythm mediates ..
  73. MELATONIN'S ROLE IN TECTAL PHYSIOLOGY AND PLASTICITY
    Susan Udin; Fiscal Year: 2003
    DESCRIPTION (Adapted from Applicant's abstract): The hormone melatonin is a molecule secreted by the brain on a circadian basis...
  74. Melatonin Analog PD6735 and Anxiety
    Frank Zemlan; Fiscal Year: 2006
    unreadable] DESCRIPTION (Provided by applicant): [unreadable] P2D, Inc. is developing a synthetic melatonin analog, PD6735, for the treatment of anxiety. Preliminary Studies suggest that PD6735 reduces anxiety in rodents...
  75. CNS MELATONIN TARGETS AND PHOTOPERIOD-INDUCED OBESITY
    Timothy Bartness; Fiscal Year: 2000
    ..Specific Aim III: Can c-Fos activity be used to identify the functional sites of reception/transmission of melatonin signals and thefr efferent projection fields? Experiments are proposed to test the hypothesis that stimulation ..
  76. Melatonin Regulation of MT2 Melatonin Receptors
    MATTHEW GERDIN; Fiscal Year: 2003
    This proposal aims to investigate the mechanisms by which melatonin (MET) regulates MT2 melatonin receptors and assess the physiological significance of these events...