juvenile hormones

Summary

Summary: Compounds, either natural or synthetic, which block development of the growing insect.

Top Publications

  1. pmc Transcriptional regulation of juvenile hormone-mediated induction of Krüppel homolog 1, a repressor of insect metamorphosis
    Takumi Kayukawa
    Division of Insect Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8634, Japan
    Proc Natl Acad Sci U S A 109:11729-34. 2012
  2. ncbi Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
    M S Rhyu
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Cell 76:477-91. 1994
  3. ncbi A nutrient sensor mechanism controls Drosophila growth
    Julien Colombani
    Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS Parc Valrose, 06108, Cedex 2, Nice, France
    Cell 114:739-49. 2003
  4. pmc Vitellogenin, juvenile hormone, insulin signaling, and queen honey bee longevity
    Miguel Corona
    Department of Entomology, University of Illinois at Urbana Champaign, 320 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 104:7128-33. 2007
  5. ncbi The mevalonate pathway and the synthesis of juvenile hormone in insects
    Xavier Belles
    Department of Physiology and Molecular Biodiversity, Institut de Biologia Molecular de Barcelona CSIC, Jordi Girona 18, 08034 Barcelona, Spain
    Annu Rev Entomol 50:181-99. 2005
  6. ncbi Krüppel homolog 1, an early juvenile hormone-response gene downstream of Methoprene-tolerant, mediates its anti-metamorphic action in the red flour beetle Tribolium castaneum
    Chieka Minakuchi
    National Institute of Agrobiological Sciences, 1 2 Ohwashi, Tsukuba 305 8634, Japan
    Dev Biol 325:341-50. 2009
  7. ncbi numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos
    T Uemura
    Howard Hughes Medical Institute, University of California, San Francisco, 94143 0724
    Cell 58:349-60. 1989
  8. pmc Juvenile hormone regulates vitellogenin gene expression through insulin-like peptide signaling pathway in the red flour beetle, Tribolium castaneum
    Zhentao Sheng
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, Kentucky 40546, USA
    J Biol Chem 286:41924-36. 2011
  9. ncbi Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata
    Terunori Kinjoh
    Faculty of Agriculture and Life Sciences, Hirosaki University, Hirosaki 036 8561, Japan
    Insect Biochem Mol Biol 37:808-18. 2007
  10. pmc Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    J Exp Biol 211:2712-24. 2008

Detail Information

Publications287 found, 100 shown here

  1. pmc Transcriptional regulation of juvenile hormone-mediated induction of Krüppel homolog 1, a repressor of insect metamorphosis
    Takumi Kayukawa
    Division of Insect Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8634, Japan
    Proc Natl Acad Sci U S A 109:11729-34. 2012
    ....
  2. ncbi Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
    M S Rhyu
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Cell 76:477-91. 1994
    ..Thus, numb functions to determine the fates of the secondary precursors; the differential distribution of numb as the SOP divides generates an asymmetric division in which the daughter cells acquire distinct identities...
  3. ncbi A nutrient sensor mechanism controls Drosophila growth
    Julien Colombani
    Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS Parc Valrose, 06108, Cedex 2, Nice, France
    Cell 114:739-49. 2003
    ..Our results demonstrate that the fat body functions as a nutrient sensor that restricts global growth through a humoral mechanism...
  4. pmc Vitellogenin, juvenile hormone, insulin signaling, and queen honey bee longevity
    Miguel Corona
    Department of Entomology, University of Illinois at Urbana Champaign, 320 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 104:7128-33. 2007
    ..These results suggest that conserved and species-specific mechanisms interact to regulate queen bee longevity without sacrificing fecundity...
  5. ncbi The mevalonate pathway and the synthesis of juvenile hormone in insects
    Xavier Belles
    Department of Physiology and Molecular Biodiversity, Institut de Biologia Molecular de Barcelona CSIC, Jordi Girona 18, 08034 Barcelona, Spain
    Annu Rev Entomol 50:181-99. 2005
    ..These data suggest that the mevalonate pathway in insects can best be interpreted in terms of coordinated regulation, in which regulators act in parallel to a number of enzymes, as occurs in the cholesterol-driven pathway in vertebrates...
  6. ncbi Krüppel homolog 1, an early juvenile hormone-response gene downstream of Methoprene-tolerant, mediates its anti-metamorphic action in the red flour beetle Tribolium castaneum
    Chieka Minakuchi
    National Institute of Agrobiological Sciences, 1 2 Ohwashi, Tsukuba 305 8634, Japan
    Dev Biol 325:341-50. 2009
    ..Therefore, TcKr-h1 is an early JH-response gene that mediates JH action linking TcMet and Tcbr...
  7. ncbi numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos
    T Uemura
    Howard Hughes Medical Institute, University of California, San Francisco, 94143 0724
    Cell 58:349-60. 1989
    ..Thus the numb gene controls the fate of progeny derived from sensory organ precursors. The numb gene has been isolated by the plasmid rescue method. The structure of its predicted product is discussed...
  8. pmc Juvenile hormone regulates vitellogenin gene expression through insulin-like peptide signaling pathway in the red flour beetle, Tribolium castaneum
    Zhentao Sheng
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, Kentucky 40546, USA
    J Biol Chem 286:41924-36. 2011
    ..FOXO protein expressed in baculovirus system binds to FOXO response element present in the Vg gene promoter. These data suggest that JH functions through insulin-like peptide signaling pathway to regulate Vg gene expression...
  9. ncbi Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata
    Terunori Kinjoh
    Faculty of Agriculture and Life Sciences, Hirosaki University, Hirosaki 036 8561, Japan
    Insect Biochem Mol Biol 37:808-18. 2007
    ..Altogether, our results point to a relationship between JH biosynthesis and expression of most JH biosynthetic enzymes in the CA...
  10. pmc Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    J Exp Biol 211:2712-24. 2008
    ..Our results suggest that 20E and JH play major roles in the regulation of gene expression in response to immune challenge...
  11. pmc Gustatory perception and fat body energy metabolism are jointly affected by vitellogenin and juvenile hormone in honey bees
    Ying Wang
    School of Life Sciences, Arizona State University, Tempe, Arizona, United States of America
    PLoS Genet 8:e1002779. 2012
    ..Thus, perhaps the bee can make general contributions to the understanding of food-related behavior and metabolic disorders...
  12. ncbi Control of daughter cell fates during asymmetric division: interaction of Numb and Notch
    M Guo
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Neuron 17:27-41. 1996
    ..This leads to Ttk expression in the daughter cell that does not inherit Numb. Thus, the inherited determinant Numb bestows a bias in the machinery for cell-cell communication to allow the specification of distinct daughter cell fates...
  13. ncbi Hormonal cross talk in insect development
    Edward B Dubrovsky
    Department of Biology, Dartmouth College, Hanover, NH 03755, USA
    Trends Endocrinol Metab 16:6-11. 2005
    ..Two transcription factors--BR-C and E75A--contribute to the cross-talk between the two hormones. It appears that BR-C is a key target of JH status quo action, and E75A is a part of the mechanism whereby JH prevents BR-C activation...
  14. ncbi Potential use of pyriproxyfen for control of Aedes aegypti (Diptera: Culicidae) in Iquitos, Perú
    Moises Sihuincha
    Laboratorio Referencial, Dirección de Salud, Iquitos, Peru
    J Med Entomol 42:620-30. 2005
    ..We review the literature on the environmental and human health effects of this compound and discuss its potential for use as a mosquito control agent in the field...
  15. ncbi Hexamerin-based regulation of juvenile hormone-dependent gene expression underlies phenotypic plasticity in a social insect
    Xuguo Zhou
    Entomology and Nematology Department, University of Florida, Gainesville, FL 32611 0620, USA
    Development 134:601-10. 2007
    ..Results are discussed in a context relative to outstanding questions on termite developmental biology, particularly on regulatory gene networks that respond to JH-, colony- and environmental-cues...
  16. ncbi Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect
    Karina R Guidugli
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    FEBS Lett 579:4961-5. 2005
    ..This role of vitellogenin in the tuning of the endocrine system is uncommon and may elucidate how an ancestral pathway of fertility regulation has been remodeled into a novel circuit controlling social behavior...
  17. ncbi The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila
    Daniela Berdnik
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Dev Cell 3:221-31. 2002
    ..Our results suggest a model in which Numb influences cell fate by downregulating Notch through polarized receptor-mediated endocytosis, since Numb also binds to the intracellular domain of Notch...
  18. ncbi Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo
    M Park
    Department of Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Mech Dev 75:117-26. 1998
    ....
  19. pmc Heterodimer of two bHLH-PAS proteins mediates juvenile hormone-induced gene expression
    Meng Li
    Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA
    Proc Natl Acad Sci U S A 108:638-43. 2011
    ..Together, the evidence indicates that Met and FISC form a functional complex on the JHRE in the presence of JH and directly activate transcription of JH target genes...
  20. pmc bHLH-PAS family transcription factor methoprene-tolerant plays a key role in JH action in preventing the premature development of adult structures during larval-pupal metamorphosis
    R Parthasarathy
    Department of Entomology, College of Agriculture, University of Kentucky, S225 Ag Science N, Lexington, KY 40546, USA
    Mech Dev 125:601-16. 2008
    The biological actions of juvenile hormones are well studied; they regulate almost all aspects of an insect's life. However, the molecular actions of these hormones are not well understood...
  21. ncbi Insect juvenile hormone: from "status quo" to high society
    K Hartfelder
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 33:157-77. 2000
    ..Its metamorphic role has been extensively explored in the morphological differentiation of queens and workers, and in the generation of worker polymorphism, such as observed in ants...
  22. ncbi A Drosophila melanogaster mutant resistant to a chemical analog of juvenile hormone
    T G Wilson
    Dev Biol 118:190-201. 1986
    ..Autonomous expression of Met was found both in abdominal cuticle as well as in external male genitalia. The characteristics of Met are consistent with those expected of a mutant having altered juvenile hormone reception in target tissue...
  23. ncbi FoxO inhibits juvenile hormone biosynthesis and vitellogenin production in the German cockroach
    Songül Süren-Castillo
    Institut de Biologia Evolutiva CSIC UPF, Passeig Marítim de la Barceloneta 37 49, 08003 Barcelona, Spain
    Insect Biochem Mol Biol 42:491-8. 2012
    ..Our results indicate that BgFoxO plays an inhibitory role on juvenile hormone biosynthesis and vitellogenin production in a situation of nutrient shortage...
  24. ncbi Cyp15F1: a novel cytochrome P450 gene linked to juvenile hormone-dependent caste differention in the termite Reticulitermes flavipes
    Matthew R Tarver
    Entomology and Nematology Department, University of Florida, Gainesville, Florida, USA
    Arch Insect Biochem Physiol 80:92-108. 2012
    ..These results also reinforce the concept of environmental caste determination in termites by revealing how primer pheromones, as socioenvironmental factors, can directly influence Cyp15 expression and caste differentiation...
  25. pmc bHLH-PAS heterodimer of methoprene-tolerant and Cycle mediates circadian expression of juvenile hormone-induced mosquito genes
    Sang Woon Shin
    Department of Entomology and the Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 109:16576-81. 2012
    ..This study provides an important insight into the understanding of the molecular basis of JH action...
  26. ncbi Nutritional regulation of JH synthesis: a mechanism to control reproductive maturation in mosquitoes?
    Fernando G Noriega
    Department of Biological Sciences, OE 167, Florida International University, 11200 SW 8th St Miami, FL 33199, USA
    Insect Biochem Mol Biol 34:687-93. 2004
    ..JH is therefore an important part of a transduction mechanism that connects changes in the nutritional status with activation of specific physiological events during reproduction...
  27. ncbi Drosophila Met and Gce are partially redundant in transducing juvenile hormone action
    Mohamed A Abdou
    Department of Entomology, University of Maryland, College Park, MD 20742, USA
    Insect Biochem Mol Biol 41:938-45. 2011
    ..5k) mutants. Our data suggest a model in which Drosophila Met and Gce redundantly transduce JH action to prevent 20E-induced caspase-dependent PCD during larval molts by induction of Kr-h1 expression and inhibition of br expression...
  28. ncbi Broad specifies pupal development and mediates the 'status quo' action of juvenile hormone on the pupal-adult transformation in Drosophila and Manduca
    Xiaofeng Zhou
    Department of Zoology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Development 129:2259-69. 2002
    ..Consequently, the 'status quo' action of JH on the pupal-adult transformation is mediated by the JH-induced re-expression of BR...
  29. ncbi Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS
    J B Skeath
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana, Illinois 61801, USA
    Development 125:1857-65. 1998
    ..Taken together, these results show that interactions between sanpodo, the Notch signaling pathway and numb enable CNS sibling neurons to acquire different fates...
  30. ncbi The origins of insect metamorphosis
    J W Truman
    Department of Zoology, University of Washington, Seattle 98195 1800, USA
    Nature 401:447-52. 1999
    ..This proposal has general implications for insect developmental biology...
  31. pmc Numb is an endocytic protein
    E Santolini
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    J Cell Biol 151:1345-52. 2000
    ..Finally, fragments of Numb act as dominant negatives on both constitutive and ligand-regulated receptor-mediated internalization, suggesting a general role for Numb in the endocytic process...
  32. ncbi A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    M Tatar
    Brown University, Providence, RI 02912, USA, University of Massachusetts, Amherst, MA 01003, USA
    Science 292:107-10. 2001
    ....
  33. ncbi Endocrine insights into the evolution of metamorphosis in insects
    James W Truman
    Department of Zoology, University of Washington, Seattle, Washington 98195 1800, USA
    Annu Rev Entomol 47:467-500. 2002
    ..We discuss how complete metamorphosis may have influenced the molecular aspects of both ecdysone and JH signaling...
  34. ncbi Identification of a juvenile hormone esterase-like gene in the honey bee, Apis mellifera L.--expression analysis and functional assays
    Aline Mackert
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Comp Biochem Physiol B Biochem Mol Biol 150:33-44. 2008
    ..The temporal profile of Amjhe-like expression in larval and adult workers, the pattern of hormonal regulation and the knockdown phenotype are consistent with the function of this gene as an authentic JHE...
  35. pmc aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb
    Christian A Smith
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    EMBO J 26:468-80. 2007
    ..These results suggest a model in which phosphorylation of Numb by aPKC regulates its polarized distribution in epithelial cells as well as during asymmetric cell divisions...
  36. ncbi Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees
    Gro V Amdam
    Department of Animal Science, Centre for Integrative Genetics, Agricultural University of Norway, P O Box 5025, 1432 Aas, Norway
    Exp Gerontol 39:767-73. 2004
    ..Our results therefore suggest that in terms of maintenance of the cellular immune system, senescence of the honeybee worker is under social control...
  37. ncbi An autodissemination station for the transfer of an insect growth regulator to mosquito oviposition sites
    R Gaugler
    Center for Vector Biology, Rutgers University, 180 Jones Avenue, New Brunswick, NJ 08901 8536, U S A
    Med Vet Entomol 26:37-45. 2012
    ..Key autodissemination station features include lack of maintenance requirements, biodegradable construction, low cost and low risk...
  38. ncbi Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Bioessays 27:999-1010. 2005
    ..In particular, we illustrate the role of JH as a key mediator of life history trade-offs...
  39. ncbi New insecticides with ecdysteroidal and juvenile hormone activity
    T S Dhadialla
    Rohm and Haas Company, Insecticide Research Laboratories, Spring House, Pennsylvania 19477, USA
    Annu Rev Entomol 43:545-69. 1998
    ..The insecticidal, ecotoxicological properties and the mode of action of the two groups of insecticides are reviewed in this article...
  40. ncbi Developmental regulation of glycolysis by 20-hydroxyecdysone and juvenile hormone in fat body tissues of the silkworm, Bombyx mori
    Ling Tian
    Key Laboratory of Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Mol Cell Biol 2:255-63. 2010
    ..Taken together, we conclude that 20E acts as a general blocker for glycolysis in the Bombyx fat body during molting and pupation, whereas the physiological role of JH is contrast with 20E during molting...
  41. ncbi Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis
    Barbora Konopova
    Biology Center, Czech Academy of Sciences, Czech Republic
    Development 135:559-68. 2008
    ..The tissue coordination role of BR-C may therefore be a part of the Holometabola groundplan...
  42. ncbi Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS
    E P Spana
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Development 121:3489-94. 1995
    ..Thus, numb is asymmetrically localized in the dividing MP2 and is necessary and sufficient to autonomously specify dMP2 neuronal identity...
  43. ncbi Juvenoid hormone methyl farnesoate is a sex determinant in the crustacean Daphnia magna
    Allen W Olmstead
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695 7633, USA
    J Exp Zool 293:736-9. 2002
    ..These results demonstrate that methyl farnesoate is capable of programming daphnid embryos to develop into males and is likely the endocrine factor responsible for initiating the sexual reproductive phase in these organisms...
  44. pmc Defining behavioral and molecular differences between summer and migratory monarch butterflies
    Haisun Zhu
    Department of Neurobiology, University of Massachusetts Medical School, Plantation Street, Worcester, MA 01605, USA
    BMC Biol 7:14. 2009
    ....
  45. ncbi Neural stem cells: balancing self-renewal with differentiation
    Chris Q Doe
    Howard Hughes Medical Institute, Institute of Neuroscience, Institute of Molecular Biology, University of Oregon, Eugene, OR, USA
    Development 135:1575-87. 2008
    ....
  46. ncbi Horizontal transfer of the insect growth regulator pyriproxyfen to larval microcosms by gravid Aedes albopictus and Ochlerotatus triseriatus mosquitoes in the laboratory
    B Dell Chism
    Department of Entomology, North Carolina State University, Raleigh, NC 27695 7647, U S A
    Med Vet Entomol 17:211-20. 2003
    ..Comparative studies of the oviposition behaviour of each mosquito are warranted and would potentially provide information needed to improve the technique...
  47. pmc Insect juvenile hormone resistance gene homology with the bHLH-PAS family of transcriptional regulators
    M Ashok
    Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
    Proc Natl Acad Sci U S A 95:2761-6. 1998
    ..Because JHAs include a diverse array of chemicals with JH activity, a mechanism whereby they can exert effects in insects through a common pathway is suggested...
  48. pmc Molecular and functional characterization of a juvenile hormone acid methyltransferase expressed in the corpora allata of mosquitoes
    Jaime G Mayoral
    Department of Biological Sciences, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
    Insect Biochem Mol Biol 39:31-7. 2009
    ....
  49. pmc Genome-wide regulation of innate immunity by juvenile hormone and 20-hydroxyecdysone in the Bombyx fat body
    Ling Tian
    Key Laboratory of Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    BMC Genomics 11:549. 2010
    ..Fat body produces humoral response molecules and hence is considered as the major organ involved in innate immunity...
  50. pmc Insecticidal juvenile hormone analogs stimulate the production of male offspring in the crustacean Daphnia magna
    Allen W Olmstead
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695 7633, USA
    Environ Health Perspect 111:919-24. 2003
    ..The occurrence of such an effect in the environment could have dire consequences on susceptible crustacean populations...
  51. ncbi Toxicity and pharmacokinetics of insect growth regulators and other novel insecticides on pupae of Hyposoter didmator (Hymenoptera: Ichneumonidae), a parasitoid of early larval instars of lepidopteran pests
    Marcela Inés Schneider
    Unidad de Protección de Cultivos, E T S I Agrónomos, E 28040 Madrid, Spain
    J Econ Entomol 96:1054-65. 2003
    ..didymator in integrated pest management (IPM) programs should be carefully evaluated. Methoxyfenozide and tebufenozide could be considered safe for this parasitoid...
  52. pmc Characterization of a juvenile hormone-regulated chymotrypsin-like serine protease gene in Aedes aegypti mosquito
    Guowu Bian
    Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Insect Biochem Mol Biol 38:190-200. 2008
    ..Knocking down expression of JHA15 resulted in no evident phenotypic changes, implying that functional redundancy exists among those proteolytic enzymes...
  53. ncbi Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones
    Michel Cusson
    Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Quebec City, Quebec G1V 4C7, Canada
    Proteins 65:742-58. 2006
    ..These results suggest that type-II FPPS plays a leading role in lepidopteran JH biosynthesis in spite of its apparently more conventional catalytic cavity...
  54. ncbi Final steps in juvenile hormone biosynthesis in the desert locust, Schistocerca gregaria
    Elisabeth Marchal
    Department of Molecular Developmental Physiology and Signal Transduction, Animal Physiology and Neurobiology, Zoological Institute, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Insect Biochem Mol Biol 41:219-27. 2011
    ..Our experiments did not show any involvement of SgFAMeT in JH biosynthesis in the desert locust. Effective and selective inhibitors of SgJHAMT and SgCYP15A1 would likely represent selective biorational locust control agents...
  55. ncbi Juvenile hormone in adult eusocial Hymenoptera: gonadotropin and behavioral pacemaker
    G E Robinson
    Department of Entomology, University of Illinois, Urbana 61801, USA
    Arch Insect Biochem Physiol 35:559-83. 1997
    ..Hypotheses concerning the evolutionary relationship between the two functions of JH in adult eusocial Hymenoptera are discussed...
  56. pmc Aldehyde dehydrogenase 3 converts farnesal into farnesoic acid in the corpora allata of mosquitoes
    Crisalejandra Rivera-Pérez
    Department of Biological Sciences, Florida International University, Miami, FL 33199, USA
    Insect Biochem Mol Biol 43:675-82. 2013
    The juvenile hormones (JHs) play a central role in insect reproduction, development and behavior. Interrupting JH biosynthesis has long been considered a promising strategy for the development of target-specific insecticides...
  57. ncbi Soldier caste influences on candidate primer pheromone levels and juvenile hormone-dependent caste differentiation in workers of the termite Reticulitermes flavipes
    Matthew R Tarver
    Department of Entomology and Nematology, University of Florida, Gainesville, FL, USA
    J Insect Physiol 57:771-7. 2011
    ..These findings provide novel evidence supporting that CAD and ALD are authentic caste-regulatory primer pheromones in Reticulitermes...
  58. pmc The transcription factor Krüppel homolog 1 is linked to hormone mediated social organization in bees
    Hagai Shpigler
    Department of Evolution, Systematics, and Ecology, The Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    BMC Evol Biol 10:120. 2010
    ....
  59. pmc Insulin-like peptide genes in honey bee fat body respond differently to manipulation of social behavioral physiology
    Kari Anne Nilsen
    University of Life Sciences, Department of Chemistry, Biotechnology and Food Science, N 1432 Aas, Norway
    J Exp Biol 214:1488-97. 2011
    ..Insect ilp functions may be better understood by broadening research to account for expression in fat body and not only brain...
  60. pmc Socio-environmental and endocrine influences on developmental and caste-regulatory gene expression in the eusocial termite Reticulitermes flavipes
    Matthew R Tarver
    Department of Entomology and Nematology, University of Florida, Gainesville, FL, USA
    BMC Mol Biol 11:28. 2010
    ....
  61. pmc Common and distinct roles of juvenile hormone signaling genes in metamorphosis of holometabolous and hemimetabolous insects
    Barbora Konopova
    Biology Center, Academy of Sciences of the Czech Republic, Ceske Budejovice, Czech Republic
    PLoS ONE 6:e28728. 2011
    ..These results show that despite considerable evolutionary distance, insects with diverse developmental strategies employ a common-core JH signaling pathway to commit to adult morphogenesis...
  62. pmc The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 14:535-46. 2008
    ..Our data describe a transit-amplifying lineage in the Drosophila nervous system and suggest that different vulnerabilities in intermediate cell types can affect the outcome of tumor suppressor loss in stem cell lineages...
  63. ncbi The juvenile hormone signaling pathway in insect development
    Marek Jindra
    Biology Center, Academy of Sciences of the Czech Republic, 37005 Ceske Budejovice, Czech Republic
    Annu Rev Entomol 58:181-204. 2013
    ..We examine the regulation and biological roles of genes acting downstream of JH and Met in insect metamorphosis. Finally, we discuss the current gaps in our understanding of JH action and outline directions for future research...
  64. ncbi Efficacy of methoprene applied at different temperatures and rates on surface substrates to control eggs and fifth instars of Plodia interpunctella
    Emily A Jenson
    Department of Entomology, 123 West Waters Hall, Kansas State University, Manhattan, KS 66506, USA
    J Econ Entomol 102:1992-2002. 2009
    ..interpunctella. Results indicate methoprene could be used in management programs to control larvae of P. interpunctella, but eggs may be able to compensate for exposure to methoprene residues on treated surfaces...
  65. ncbi How does juvenile hormone control insect metamorphosis and reproduction?
    Lynn M Riddiford
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Gen Comp Endocrinol 179:477-84. 2012
    ..Critical actions of JH and its receptor in the timing of maturation of the adult optic lobe and of female receptivity in Drosophila are also discussed...
  66. pmc A coordinated expression of biosynthetic enzymes controls the flux of juvenile hormone precursors in the corpora allata of mosquitoes
    Marcela Nouzova
    Department of Biological Sciences, Florida International University, 11200 SW 8th St, Miami, FL 33199, USA
    Insect Biochem Mol Biol 41:660-9. 2011
    ..In glands with low synthetic activity, the flux of isoprenoids might be limited by the activity of enzymes with low levels of expression...
  67. ncbi Spatial expression of the mevalonate enzymes involved in juvenile hormone biosynthesis in the corpora allata in Bombyx mori
    Hiroto Ueda
    Faculty of Agriculture and Life Sciences, Hirosaki University, Hirosaki 036 8561, Japan
    J Insect Physiol 55:798-804. 2009
    ..Only female adult CA synthesized JH in B. mori, and the CA and the nuclei were significantly larger than those of male CA which do not synthesize JH...
  68. ncbi Insulin/IGF signaling regulates the change in commitment in imaginal discs and primordia by overriding the effect of juvenile hormone
    Takashi Koyama
    Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
    Dev Biol 324:258-65. 2008
    ..Thus, the Manduca bombyxin acts as a metamorphosis-initiating factor in the imaginal precursors...
  69. ncbi The morphostatic actions of juvenile hormone
    James W Truman
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Insect Biochem Mol Biol 37:761-70. 2007
    ..This suppression of embryonic patterning then results in embryonic fields that remain dormant as long as JH is present. These are the primordia that can transform into imaginal discs once JH disappears in preparation for metamorphosis...
  70. ncbi Sequence of the hexameric juvenile hormone-binding protein from the hemolymph of Locusta migratoria
    R P Braun
    Department of Biology, Queen s University, Kingston, Ontario, K7L 3N6 Canada
    J Biol Chem 271:31756-62. 1996
    ..Hybridization analysis of fat body JHBP mRNA in locusts that had been treated with precocene and a JH analog did not give clear evidence for regulation by JH...
  71. ncbi Regulation of juvenile hormone synthesis in wild-type and apterous mutant Drosophila
    M Altaratz
    Department of Entomology, Hebrew University, Rehovot, Israel
    Mol Cell Endocrinol 81:205-16. 1991
    ..Allatostatin production in the brain appears to be positively regulated by JHB3. Adult corpora allata from the mutants ap4 and ap56f synthesize very low levels of JH; additionally, brains of ap56f homozygotes lack allatostatic activity...
  72. ncbi Juvenile hormone analogs do not affect directly the activity of the ecdysteroid receptor complex in insect culture cell lines
    Thomas Soin
    Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, Ghent, Belgium
    J Insect Physiol 54:429-38. 2008
    During insect development, ecdysteroids and juvenile hormones (JHs) interact to regulate larval growth, metamorphosis and reproduction but the molecular mechanisms by which both hormones influence each other's activity remain unknown...
  73. ncbi Molecular cloning and characterization of a juvenile hormone esterase gene from brown planthopper, Nilaparvata lugens
    Shuhua Liu
    Key Laboratory of Monitoring and Management of Plant Disease and Insect, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China
    J Insect Physiol 54:1495-502. 2008
    ..These data suggest that NlJHE might play important roles in regulation of JH levels and wing form differentiation...
  74. pmc A role for juvenile hormone in the prepupal development of Drosophila melanogaster
    Lynn M Riddiford
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Development 137:1117-26. 2010
    ..Thus, the lack of JH and its receptor Met causes a heterochronic shift in the development of the visual system that is likely to result from some cells 'misinterpreting' the ecdysteroid peaks that drive metamorphosis...
  75. ncbi Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila
    Sheetal Bhalerao
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Curr Biol 15:1583-90. 2005
    ..Our results suggest that two classes of asymmetric cell division exist, each with different requirements for asymmetric inheritance of cell-fate determinants...
  76. ncbi Field evaluation of an insect growth regulator, pyriproxyfen 0.5% GR against Culex quinquefasciatus, the vector of Bancroftian filariasis in Pondicherry, India
    P Jambulingam
    Vector Control Research Centre Indian Council of Medical Research, Ministry of Health and Family Welfare, Govt of India, Indira Nagar, Pondicherry 605 006, India
    Acta Trop 107:20-4. 2008
    ..5% GR has a relatively longer residual effect than the other IGRs the operational cost could be minimized. Pyriproxyfen 0.5% GR could be one of the choices in the chemical control strategy in Integrated Vector Control Programmes...
  77. ncbi Juvenile hormone action: a 2007 perspective
    Lynn M Riddiford
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    J Insect Physiol 54:895-901. 2008
    ..This short review highlights the recent papers of the past year that lend new insight into the role of this hormone in the larva and the mechanisms whereby it achieves this role...
  78. pmc The pupal specifier broad directs progressive morphogenesis in a direct-developing insect
    Deniz F Erezyilmaz
    Department of Biology, University of Washington, Box 351800, Seattle, WA 98195 1800, USA
    Proc Natl Acad Sci U S A 103:6925-30. 2006
    ..After this shift in br expression, the progressive changes that occur within the nymphal series in basal insects became compressed to the one short period of morphogenesis seen in the larva-to-pupa transition of holometabolous insects...
  79. pmc Downregulation of vitellogenin gene activity increases the gustatory responsiveness of honey bee workers (Apis mellifera)
    Gro V Amdam
    Arizona State University, School of Life Sciences, Tempe, AZ 85287 4501, USA
    Behav Brain Res 169:201-5. 2006
    ..Our observations suggest that vitellogenin is an important regulator of long-term changes in honey bee behavior...
  80. ncbi The juvenile hormone (JH) epoxide hydrolase gene in the honey bee (Apis mellifera) genome encodes a protein which has negligible participation in JH degradation
    Aline Mackert
    Departamento de Ciências do Ambiente, Campus do Pantanal, Universidade Federal do Mato Grosso do Sul, Mato Grosso do Sul, Brazil
    J Insect Physiol 56:1139-46. 2010
    ..High AmJHEH levels in larvae and adults were related to the ingestion of high loads of lipids, suggesting that AmJHEH has a role in dietary lipid catabolism...
  81. ncbi Physiological correlates of division of labor among similarly aged honey bees
    Z Y Huang
    Department of Entomology, University of Illinois, Urbana 61801
    J Comp Physiol A 174:731-9. 1994
    ..JH may be involved in the regulation of division of labor among similarly aged workers in addition to its role in age-related division of labor...
  82. pmc Using adult mosquitoes to transfer insecticides to Aedes aegypti larval habitats
    Gregor J Devine
    Department of Plant and Invertebrate Ecology, Rothamsted Research, Harpenden AL5 2JQ, United Kingdom
    Proc Natl Acad Sci U S A 106:11530-4. 2009
    ..A deterministic simulation model predicts amplifications in coverage consistent with our observations and highlights the importance of the residual activity of the insecticide for this technique...
  83. ncbi RNAi-mediated knockdown of juvenile hormone acid O-methyltransferase gene causes precocious metamorphosis in the red flour beetle Tribolium castaneum
    Chieka Minakuchi
    National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    FEBS J 275:2919-31. 2008
    ..Together, these results demonstrate that TcMT3 encodes a functional JHAMT gene that is essential for juvenile hormone biosynthesis and for the maintenance of larval status...
  84. ncbi Juvenile hormone acid methyl transferase is a key regulatory enzyme for juvenile hormone synthesis in the Eri silkworm, Samia cynthica ricini
    Zhentao Sheng
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Arch Insect Biochem Physiol 69:143-54. 2008
    ..cynthia ricini and the pharate adults of the silkworm Bombyx mori. We infer from these results that JHAMT is a key regulatory enzyme for JH synthesis in the Eri silkworm...
  85. ncbi Juvenile hormone counteracts the bHLH-PAS transcription factors MET and GCE to prevent caspase-dependent programmed cell death in Drosophila
    Ying Liu
    Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Development 136:2015-25. 2009
    ..For the first time, we demonstrate that JH counteracts MET and GCE to prevent caspase-dependent PCD in controlling fat body remodeling and larval-pupal metamorphosis in Drosophila...
  86. pmc Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
    Salvatore Pece
    Istituto Europeo di Oncologia, 20141 Milan, Italy
    J Cell Biol 167:215-21. 2004
    ..Thus, the Numb/Notch biological antagonism is relevant to the homeostasis of the normal mammary parenchyma and its subversion contributes to human mammary carcinogenesis...
  87. ncbi The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein
    C A Dye
    Department of Cell Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Development 125:1845-56. 1998
    ..Loss of sanpodo leads to an aberrant F-actin distribution and causes differentiation defects of actin-containing sensory structures. Our data suggest that an actin-based process is involved in Notch signaling...
  88. ncbi Juvenile hormone acid O-methyltransferase in Drosophila melanogaster
    Ryusuke Niwa
    Initiative for the Promotion of Young Scientists Independent Research, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Insect Biochem Mol Biol 38:714-20. 2008
    ....
  89. ncbi Apis mellifera ultraspiracle: cDNA sequence and rapid up-regulation by juvenile hormone
    A R Barchuk
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    Insect Mol Biol 13:459-67. 2004
    ..These characteristics and the rapid up-regulation by JH suggest that some of the USP functions in the honey bee may depend on ligand binding...
  90. ncbi Developmental profile and hormonal regulation of the transcription factors broad and Krüppel homolog 1 in hemimetabolous thrips
    Chieka Minakuchi
    Graduate School of Bio agricultural Sciences, Nagoya University, Furocho, Chikusa, Nagoya 464 8601, Japan
    Insect Biochem Mol Biol 41:125-34. 2011
    ..brevitubus. Treatment with JHM to newly molted propupae caused prolonged expression of Kr-h1 and br in both species, suggesting that Kr-h1 and br could be involved in mediating anti-metamorphic signals of JHM...
  91. ncbi Juvenile hormone III titers and regulation of soldier caste in coptotermes formosanus (Isoptera: Rhinotermitidae)
    Yong Ihl Park
    Formosan Subterranean Termite Research Unit, Agricultural Research Service, USDA, SRRC, 1100 Robert E Lee Boulevard, New Orleans, LA 70124, USA
    J Insect Physiol 50:561-6. 2004
    ..It appears that the application of JHA, while inducing pre-soldier formation, does not increase the endogenous JH III titer. The titer, however, increased as the pre-soldiers aged and before transforming into soldiers...
  92. ncbi Endocrine analysis in evolutionary-developmental studies of insect polymorphism: hormone manipulation versus direct measurement of hormonal regulators
    Anthony J Zera
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Evol Dev 9:499-513. 2007
    ..Some of the most important of these assays will be briefly described and their strengths and weaknesses will be discussed...
  93. ncbi Juvenile hormone involvement in Drosophila melanogaster male reproduction as suggested by the Methoprene-tolerant(27) mutant phenotype
    Thomas G Wilson
    Department of Entomology, Ohio State University, Columbus, OH 43210, USA
    Insect Biochem Mol Biol 33:1167-75. 2003
    ....
  94. pmc Comparative genomics of insect juvenile hormone biosynthesis
    F G Noriega
    Department of Biological Sciences, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
    Insect Biochem Mol Biol 36:366-74. 2006
    ..ESTs are deposited in GenBank under the accession numbers DV 017592-DV 018447 (Diploptera punctata); DR 746432-DV 747949 (Aedes aegypti); and DR 747950-DR 748310 (Anopheles albimanus)...
  95. ncbi Effects of soldier-derived terpenes on soldier caste differentiation in the termite Reticulitermes flavipes
    Matthew R Tarver
    Entomology and Nematology Department, University of Florida, Gainesville, 32611 0620, USA
    J Chem Ecol 35:256-64. 2009
    ..These findings reveal a novel primer pheromone-like function for soldier-derived terpenes in termites and further suggest convergent evolution of terpene functions in enhancing JH-dependent soldier caste differentiation...
  96. pmc Juvenile hormone acid methyltransferase: a key regulatory enzyme for insect metamorphosis
    Tetsuro Shinoda
    National Institute of Vegetable and Tea Science, National Agricultural Research Organization, Kusawa 360, Ano, Mie 514 2392, Japan
    Proc Natl Acad Sci U S A 100:11986-91. 2003
    ....
  97. ncbi Only one esterase of Drosophila melanogaster is likely to degrade juvenile hormone in vivo
    Erica J Crone
    CSIRO Entomology, Canberra, ACT, Australia
    Insect Biochem Mol Biol 37:540-9. 2007
    ..Genomic comparisons of the selective JHE across 11 other Drosophila species showed a single orthologue in 10 of them but Drosophila willistoni has 16 full-length copies, five of them with the GQSAG motif and amphipathic helix...
  98. pmc Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization
    Frederik Wirtz-Peitz
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Cell 135:161-73. 2008
    ..Our data reveal a molecular mechanism for the asymmetric localization of Numb and show how cell polarity can be coupled to cell-cycle progression...
  99. ncbi Effects of juvenile hormone mimics on larval development and metamorphosis of Drosophila melanogaster
    L M Riddiford
    Department of Zoology, University of Washington, Seattle 98195
    Gen Comp Endocrinol 82:172-83. 1991
    ..Thus, commitment for adult differentiation must occur early during this proliferative phase...
  100. ncbi A perspective for understanding the modes of juvenile hormone action as a lipid signaling system
    Diana E Wheeler
    Department of Entomology, University of Arizona, Tucson 85721, USA
    Bioessays 25:994-1001. 2003
    The juvenile hormones of insects regulate an unusually large diversity of processes during postembryonic development and adult reproduction...
  101. ncbi Juvenile hormone binding protein traffic -- Interaction with ATP synthase and lipid transfer proteins
    Marta Zalewska
    Department of Biochemistry, Faculty of Chemistry, Wrocław University of Technology, Wybrzeze Wyspianskiego 27, 50 370, Wrocław, Poland
    Biochim Biophys Acta 1788:1695-705. 2009
    ..These results provide the first demonstration of the physical interaction of JHBP with membrane and hemolymph proteins which can be involved in JHBP molecule traffic...

Research Grants41

  1. Development of an autodissemination station for control of mosquito vectors
    Yi Wang; Fiscal Year: 2012
    ....
  2. JUVENILE HORMONE REGULATION OF GENE EXPRESSION
    WALTER GOODMAN; Fiscal Year: 2003
    Of central importance to insect growth, development and reproduction are the juvenile hormones (JH). Agonists of this hormone family are important alternatives for the control of medically important insect disease vectors...
  3. INTERFERENCE WITH STEROID RESPONSE GENES IN LEPIDOPTERA
    Lynn Riddiford; Fiscal Year: 2002
    ..abstract_text> ..
  4. ENDOCRINE CONTROL OF VITELLOGENESIS IN DROSOPHILA
    David Richard; Fiscal Year: 2002
    ..provided by the applicant): This proposal continues the re-evaluation of the roles of ecdysterolds and juvenile hormones (JH) in vitellogenesis in female Drosophila melanogaster Initiated during the original granting period (NIH ..
  5. BIODEGRADABLE PESTICIDES BASED ON HORMONE METABOLISM
    Bruce Hammock; Fiscal Year: 1980
    ..Similar studies will be carried out with insect epoxide hydrases. II. The mechanism of action of anti-juvenile hormones will be explored by investigating the action of imidazole inhibitors of JH biosynthesis and by exploring the ..
  6. STEROID RECEPTORS AND CNS DEVELOPMENT
    JAMES TRUMAN; Fiscal Year: 2007
    ..5) Use EcR dominant-negative mutations to selectively suppress cytodynamic modules to establish the role of each on growth dynamics and on the final form of the arbor. ..
  7. HORMONE ACTION ON THE CNS
    JAMES TRUMAN; Fiscal Year: 2009
    ..Understanding these issues is fundamental to normal brain development and for using stem cells to repair brain disease. ..
  8. Role of USP Ligand Binding Pocket During Development
    Grace Jones; Fiscal Year: 2008
    ..The outcome will have broad implications for insect endocrinology, enabling specific tests on the Aedes USP, the results of which will yield new insights on hormonal signaling in the technically more difficult mosquito. ..
  9. Juvenile Hormone Receptor in Flies and Mosquitoes
    Thomas Wilson; Fiscal Year: 2007
    ..In addition, a better understanding of Met as a bHLH-PAS gene will further our knowledge of this family of transcriptional regulators, including homologous genes found in humans. [unreadable] [unreadable]..
  10. Nutritional and endocrine control of mosquito egg development.
    Aparna Telang; Fiscal Year: 2008
    ..Identification and characterization of these genes should expand our understanding of hematophagy and pathogen transmission in mosquito vectors. [unreadable] [unreadable] [unreadable] [unreadable]..
  11. Cyanohydrin based fluorescent substrates of sEH (RMI)
    Christophe Morisseau; Fiscal Year: 2004
    ..This will be done by screening the combinatorial libraries from the "NIH Roadmap", libraries contracted from commercial vendors, and more defined libraries generated in house. ..
  12. PREPUPAL ACTIVATION OF JH ESTERASE GENE
    Grace Jones; Fiscal Year: 2003
    ..abstract_text> ..
  13. REGULATION OF JUVENILE HORMONE SYNTHESIS
    Barbara Stay; Fiscal Year: 2003
    ....
  14. STRUCTURAL AND FUNCTIONAL LIGAND-BINDING FEATURES OF USP
    Grace Jones; Fiscal Year: 2002
    ....
  15. 2004 Genes and Behavior Gordon Conference
    Gene Robinson; Fiscal Year: 2004
    ..Preference will be given to members of underrepresented groups and junior colleagues (graduate students, postdoctoral associates, and new assistant professors). ..
  16. Anti-larval measures for malaria control in The Gambia
    Steven Lindsay; Fiscal Year: 2007
    ..The results from this study will make a major contribution to quantifying the importance of the use of Bs and Bti in the fight against malaria. ..
  17. GABAERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
    ....
  18. REGULATION OF INSECT JUVENILE HORMONE BIOSYNTHESIS
    LINDA RESTIFO; Fiscal Year: 2001
    ..farnesoate epoxidase, the enzyme that introduces the epoxide moiety characteristic of the sesquiterpenoid juvenile hormones. The other P450 is CYP4C7, which has been cloned, sequenced, and shown in preliminary studies to be related ..
  19. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2009
    ..Our results will also suggest directions for the development of treatments for the decline in mental function that accompanies human aging. ..
  20. Intracellular transfer of cholesterol in mosquitoes
    Que Lan; Fiscal Year: 2010
    ..The results will also validate the potential of targeting cholesterol metabolism for the development of new strategies to control mosquito populations. ..
  21. The Role of Arf GTPases in Endocytosis and Postendocytic Transport
    James E Casanova; Fiscal Year: 2010
    ....
  22. Molecular mechanisms of queen bee longevity
    Gene Robinson; Fiscal Year: 2006
    ..The value of the bee as an aging model will be enhanced significantly with the expected completion of genome sequencing later in '03. ..
  23. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  24. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2010
    ..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
  25. Regulation of Stable Fat Loss in a Model System
    Gene E Robinson; Fiscal Year: 2010
    ..The goal of this proposal is to use genomic and systems biology techniques to identify "switch" genes that enable stable weight loss in the bee, and to test that these genes regulate body weight and energy metabolism in mammals. ..
  26. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2010
    ....
  27. Pheromone regulation of gene expression in the brain
    Gene Robinson; Fiscal Year: 2007
    ..abstract_text> ..
  28. CADDMR: a Cell-based Assay for Drug Discovery for Mental Retardation Disorders
    LINDA RESTIFO; Fiscal Year: 2007
    ..The proposed experiments are an important step toward that goal. [unreadable] [unreadable] [unreadable]..
  29. SOCIAL AND NEUROENDOCRINE REGULATION OF THE PERIOD GENE
    Gene Robinson; Fiscal Year: 2002
    ..abstract_text> ..
  30. CONTROL OF CNS DEVELOPMENT BY BRC TRANSCRIPTION FACTORS
    LINDA RESTIFO; Fiscal Year: 2005
    ..Defining molecular pathways between hormonal signals and specific events in brain development should lead to better therapeutic strategies for treating CNS dysfunction due to congenital and acquired disorders. ..
  31. Role of the GTPase ARF6 in Epithelial Cell Migration
    James Casanova; Fiscal Year: 2005
    ..abstract_text> ..
  32. Perlecan-Mediated Control of Prostate Cancer Progression
    Sumana Datta; Fiscal Year: 2005
    ..These studies will link proteoglycan expression, signaling function and sugar structure to cancer progression. ..
  33. CONTROL OF NEUROBLAST PROLIFERATION IN DROSOPHILA
    Sumana Datta; Fiscal Year: 2006
    ..These studies will provide important insights into the mechanism(s) by which stem cell division is controlled by developmental cues--a process of fundamental importance in all animals, including humans. ..
  34. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
    ..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
  35. CHOLINERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2006
    ....
  36. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2003
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
  37. Neuromodulation of excessive reward-directed behavior
    Gene Robinson; Fiscal Year: 2006
    ..Extensive conservation of nervous system function at the molecular level across the animal kingdom indicates that the principles of reward coding we aim to elucidate in the bee will have general relevance. ..
  38. TRANSEPITHELIAL TRANSPORT OF IMMUNOGLOBULINS
    James Casanova; Fiscal Year: 2002
    ..These studies will provide insight into the mechanisms by which macromolecules are transported across epithelia, a process that is particularly important in the mucosal immunity. ..
  39. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..
  40. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2007
    ..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span [unreadable] [unreadable]..
  41. Functional Analysis of Mouse Numb and Numblike in Neural Development
    Weimin Zhong; Fiscal Year: 2010
    ..Such knowledge may point to mechanisms that cause brain cells to revert to less differentiated states in brain tumors or degenerate in neurological disorders. ..