insect hormones

Summary

Summary: Hormones secreted by insects. They influence their growth and development. Also synthetic substances that act like insect hormones.

Top Publications

  1. ncbi Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
    Seung K Kim
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, Stanford, California 94305 5329, USA
    Nature 431:316-20. 2004
  2. ncbi Comparative peptidomics of four related hemipteran species: pyrokinins, myosuppressin, corazonin, adipokinetic hormone, sNPF, and periviscerokinins
    Reinhard Predel
    Areawide Pest Management Research, Southern Plains Agricultural Research Center, USDA, 2881 F B Road, College Station, TX 77845, USA
    Peptides 29:162-7. 2008
  3. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
  4. pmc Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster
    Gyunghee Lee
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Genetics 167:311-23. 2004
  5. ncbi The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis
    Kim F Rewitz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Science 326:1403-5. 2009
  6. pmc Prothoracicotropic hormone regulates developmental timing and body size in Drosophila
    Zofeyah McBrayer
    The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 13:857-71. 2007
  7. pmc Genomics, transcriptomics, and peptidomics of neuropeptides and protein hormones in the red flour beetle Tribolium castaneum
    Bin Li
    Department of Entomology, Kansas State University, Manhattan, Kansas 66506 4004, USA
    Genome Res 18:113-22. 2008
  8. ncbi Regulatory peptides in fruit fly midgut
    Jan A Veenstra
    CNIC UMR 5228 CNRS, Universite Bordeaux 1, 33400, Talence, France
    Cell Tissue Res 334:499-516. 2008
  9. ncbi The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster
    Christen Mirth
    Department of Biology, Box 351800, University of Washington, Seattle, Washington 98195, USA
    Curr Biol 15:1796-807. 2005
  10. pmc Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster
    Huanfa Liu
    Zoological Institute, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:9929-33. 2003

Research Grants

Detail Information

Publications227 found, 100 shown here

  1. ncbi Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
    Seung K Kim
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, Stanford, California 94305 5329, USA
    Nature 431:316-20. 2004
    ..Thus, Drosophila CC cells are crucial regulators of glucose homeostasis and they use glucose-sensing and response mechanisms similar to islet cells...
  2. ncbi Comparative peptidomics of four related hemipteran species: pyrokinins, myosuppressin, corazonin, adipokinetic hormone, sNPF, and periviscerokinins
    Reinhard Predel
    Areawide Pest Management Research, Southern Plains Agricultural Research Center, USDA, 2881 F B Road, College Station, TX 77845, USA
    Peptides 29:162-7. 2008
    ..The forthcoming release of the genome from the reduviid Rhodnius prolixus will provide sufficient data to clear this point...
  3. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    ..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus...
  4. pmc Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster
    Gyunghee Lee
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Genetics 167:311-23. 2004
    ..From these findings, we propose another role for AKH in the regulation of starvation-induced foraging behavior...
  5. ncbi The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis
    Kim F Rewitz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Science 326:1403-5. 2009
    ..We conclude that PTTH initiates metamorphosis by activation of the Torso/ERK pathway...
  6. pmc Prothoracicotropic hormone regulates developmental timing and body size in Drosophila
    Zofeyah McBrayer
    The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 13:857-71. 2007
    ..These results indicate that final body size in insects is determined by a balance between growth-rate regulators such as insulin and developmental timing cues such as PTTH that set the duration of the feeding interval...
  7. pmc Genomics, transcriptomics, and peptidomics of neuropeptides and protein hormones in the red flour beetle Tribolium castaneum
    Bin Li
    Department of Entomology, Kansas State University, Manhattan, Kansas 66506 4004, USA
    Genome Res 18:113-22. 2008
    ..Our analysis of Tribolium indicates that, during insect evolution, genes for neuropeptides and protein hormones are often duplicated or lost...
  8. ncbi Regulatory peptides in fruit fly midgut
    Jan A Veenstra
    CNIC UMR 5228 CNRS, Universite Bordeaux 1, 33400, Talence, France
    Cell Tissue Res 334:499-516. 2008
    ..Although the Drosophila insulin gene Ilp3 was abundantly expressed in the midgut, Ilp3 was not expressed in endocrine cells, but in midgut muscle...
  9. ncbi The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster
    Christen Mirth
    Department of Biology, Box 351800, University of Washington, Seattle, Washington 98195, USA
    Curr Biol 15:1796-807. 2005
    ..We present evidence that in Drosophila, a component of the ring gland, the prothoracic gland (PG), assesses growth to determine when critical weight has been achieved...
  10. pmc Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster
    Huanfa Liu
    Zoological Institute, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:9929-33. 2003
    ..The second conclusion is supported by the finding that SP binds to sperm. The 36-aa-encoding SP gene is the first small Drosophila gene knocked out with the method of homologous recombination...
  11. ncbi A phosphoproteomics approach to elucidate neuropeptide signal transduction controlling insect metamorphosis
    Kim F Rewitz
    The Department of Science, Systems and Models, Roskilde University, 4000 Roskilde, Denmark
    Insect Biochem Mol Biol 39:475-83. 2009
    ..This directly connects PTTH signaling to the pathway that produces E. A new mechanism for regulation of E biosynthesis in insects is proposed...
  12. pmc Neuroendocrine regulation of Drosophila metamorphosis requires TGFbeta/Activin signaling
    Ying Y Gibbens
    Department of Genetics Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Development 138:2693-703. 2011
    ..As steroid hormone production in C. elegans and mammals is also influenced by TGFβ/Activin signaling, this family of secreted factors may play a general role in regulating developmental transitions across phyla...
  13. pmc Function and composition of male accessory gland secretions in Anopheles gambiae: a comparison with other insect vectors of infectious diseases
    Francesco Baldini
    University of Perugia, Italy
    Pathog Glob Health 106:82-93. 2012
    ..Knowledge of the factors and mechanisms regulating fertility in An. gambiae and other vectors can help the design of novel control strategies to fight the spread of disease...
  14. ncbi Energetics of insect diapause
    Daniel A Hahn
    Department of Entomology and Nematology, University of Florida, Gainesville, Florida 32611, USA
    Annu Rev Entomol 56:103-21. 2011
    ..We also discuss other possible candidates for diapause-associated nutrient regulation including adipokinetic hormone, neuropeptide F, the cGMP-kinase For, and AMPK...
  15. ncbi Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
    W Li
    Department of Biological Sciences, Columbia University, New York, New York 10027
    Cell 80:553-62. 1995
    ..PKA therefore appears to be an integral component of the mechanism by which hh regulates the expression of key patterning molecules in imaginal discs...
  16. ncbi Involvement of PI3K/Akt signaling in PTTH-stimulated ecdysteroidogenesis by prothoracic glands of the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung 404, Taiwan, ROC
    Insect Biochem Mol Biol 41:197-202. 2011
    ..mori prothoracic glands between insulin and PTTH signaling, which may play a critical role in precisely regulated ecdysteroidogenesis during development...
  17. ncbi The ecdysteroidogenic P450 Cyp302a1/disembodied from the silkworm, Bombyx mori, is transcriptionally regulated by prothoracicotropic hormone
    R Niwa
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha, Kashiwa, Chiba, Japan
    Insect Mol Biol 14:563-71. 2005
    ..Furthermore, dib-Bm expression in cultured PGs is significantly induced by treatment with prothoracicotropic hormone. This is the first report on the transcriptional induction of a steroidogenic gene by the tropic hormone in insects...
  18. ncbi Regulation of intermediary metabolism and water balance of insects by neuropeptides
    Gerd Gäde
    Zoology Department, University of Cape Town, ZA 7701 Rondebosch, South Africa
    Annu Rev Entomol 49:93-113. 2004
    ..Biosynthesis, release, receptors, mode of action, inactivation, structure-activity studies, and biological functions are discussed for the various peptides...
  19. ncbi Biochemical and cytoimmunological evidence for the control of Aedes aegypti larval trypsin with Aea-TMOF
    Dov Borovsky
    University of Florida IFAS, Florida Medical Entomology Laboratory, Vero Beach, 32962, USA
    Arch Insect Biochem Physiol 55:124-39. 2004
    ..These results indicate that TMOF-immunoreactive material is synthesized in sugar-fed male and female adults and larvae by the central nervous system cells...
  20. ncbi A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling
    Erik C Johnson
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Biol 208:1239-46. 2005
    ..Therefore, it appears that both the molecular details as well as the functional organization of CGRP signaling have been conserved...
  21. ncbi Neuropeptide evolution: neurohormones and neuropeptides predicted from the genomes of Capitella teleta and Helobdella robusta
    Jan A Veenstra
    Universite de Bordeaux, INCIA UMR 5287 CNRS, 33400 Talence, France
    Gen Comp Endocrinol 171:160-75. 2011
    ....
  22. ncbi Functional analysis of four neuropeptides, EH, ETH, CCAP and bursicon, and their receptors in adult ecdysis behavior of the red flour beetle, Tribolium castaneum
    Yasuyuki Arakane
    Department of Biochemistry, Chalmers Hall, Kansas State University, Manhattan, KS 66506, USA
    Mech Dev 125:984-95. 2008
    ..Results from this study suggest that the functions of neuropeptidergic systems that drive innate ecdysis behavior have undergone significant changes during the evolution of arthropods...
  23. ncbi The Drosophila melanogaster homologue of an insect calcitonin-like diuretic peptide stimulates V-ATPase activity in fruit fly Malpighian tubules
    G M Coast
    Department of Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK
    J Exp Biol 204:1795-804. 2001
    ..Since the K+ concentration of the secreted urine was unchanged, it is likely that Drome-DH31 has an equal effect on K+ and Na+ entry across the basolateral membrane...
  24. ncbi A command chemical triggers an innate behavior by sequential activation of multiple peptidergic ensembles
    Young Joon Kim
    Department of Entomology, 5429 Boyce Hall, University of California, Riverside, 92521, USA
    Curr Biol 16:1395-407. 2006
    ..Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system...
  25. ncbi Neuroendocrinological and molecular aspects of insect reproduction
    G Simonet
    Laboratory for Developmental Physiology, Genomics and Proteomics, Department of Animal Physiology and Neurobiology, Zoological Institute, KU Leuven, Leuven, Belgium
    J Neuroendocrinol 16:649-59. 2004
    ..This review highlights several neuropeptides controlling the biosynthesis and release of the 'classic' insect hormones, as well as various peptides and biogenic amines that regulate behavioural aspects of the reproduction ..
  26. ncbi Putative regulatory mechanism of prothoracicotropic hormone (PTTH) secretion in the American cockroach, Periplaneta americana as inferred from co-localization of Rab8, PTTH, and protein kinase C in neurosecretory cells
    Susumu Hiragaki
    Graduate School of Agricultural Science, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    Cell Tissue Res 335:607-15. 2009
    ..These findings support the notion that Rab8-like antigen is phosphorylated by PKC, and that this phosphorylation is involved in the axonal transport and secretion of PTTH in this species...
  27. ncbi Stimulation of JH biosynthesis by the corpora allata of adult female Aedes aegypti in vitro: effect of farnesoic acid and Aedes allatotropin
    Yiping Li
    Department of Biochemistry and Molecular Biophysics and Center for Insect Science, University of Arizona, Tucson, AZ 85721 0088, USA
    J Exp Biol 206:1825-32. 2003
    ..These data suggest that in sugar-fed females, FA and Aedes-AT exert different effects on the terminal steps in JH biosynthesis...
  28. ncbi Neurohormones and neuropeptides encoded by the genome of Lottia gigantea, with reference to other mollusks and insects
    Jan A Veenstra
    Universite de Bordeaux, CNRS, CNIC UMR 5228, 33400 Talence, France
    Gen Comp Endocrinol 167:86-103. 2010
    ....
  29. ncbi Characterization of an allatotropin-like peptide receptor in the red flour beetle, Tribolium castaneum
    Kristel Vuerinckx
    Insect Physiology and Molecular Ethology, KU Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Insect Biochem Mol Biol 41:815-22. 2011
    ..The endogenous ligand of the receptor, Trica-ATL, is able to increase the frequency and tonus of contractions in the gut and in the reproductive tract of mature red flour beetles...
  30. ncbi Trypsin-modulating oostatic factor: a potential new larvicide for mosquito control
    D Borovsky
    University of Florida IFAS, Florida Medical Entomology Laboratory, 200 9th Street, SE Vero Beach, FL 332962, USA
    J Exp Biol 206:3869-75. 2003
    ..and Saccharomyces cerevisiae cells and feeding the recombinant cells to mosquito larvae caused larval mortality. These results indicate that TMOF can be used as a new biorational insecticide against mosquito larvae...
  31. ncbi Isolation and functional characterization of an allatotropin receptor from Manduca sexta
    Frank M Horodyski
    Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, OH, USA
    Insect Biochem Mol Biol 41:804-14. 2011
    ..In the adult corpora cardiaca--corpora allata complex, Manse-ATR mRNA is present at relatively low levels in both sexes...
  32. ncbi Transcriptional regulation of the PTTH receptor in prothoracic glands of the silkworm, Bombyx mori
    Shun Chieh Young
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung, Taiwan 404, ROC
    J Insect Physiol 58:102-9. 2012
    ....
  33. ncbi Conservation of ecdysis-triggering hormone signalling in insects
    D Zitnan
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 84206 Bratislava, Slovakia
    J Exp Biol 206:1275-89. 2003
    ..Our results suggest that Inka cells of different insects produce only peptide hormones closely related to PETH and ETH, which are essential endocrine factors required for activation of the ecdysis behavioural sequence...
  34. ncbi Expression profiles of glutathione S-transferase genes in larval midgut of Bombyx mori exposed to insect hormones
    Feng Ming Zou
    School of Biology and Environmental Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212018, China
    Mol Biol Rep 38:639-47. 2011
    ..However, further validation and field trials should be carried out on the regulatory elements relevant to BmGSTD2 and BmGSTS2 gene expression...
  35. pmc The putative AKH receptor of the tobacco hornworm, Manduca sexta, and its expression
    R Ziegler
    Department of Entomology, The University of Arizona, Tucson, AZ 85721, USA
    J Insect Sci 11:40. 2011
    ..We also compare the M. sexta adipokinetic hormone receptor with the known adipokinetic hormone receptors of other insects and with gonadotropin releasing hormone-like receptors of invertebrates...
  36. ncbi Peptidomic survey of the locust neuroendocrine system
    Elke Clynen
    Research Group Functional Genomics and Proteomics, K U Leuven, Naamsestraat 59, 3000 Leuven, Belgium
    Insect Biochem Mol Biol 39:491-507. 2009
    ....
  37. pmc Bombyx prothoracicostatic peptides activate the sex peptide receptor to regulate ecdysteroid biosynthesis
    Naoki Yamanaka
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba 277 8562, Japan
    Proc Natl Acad Sci U S A 107:2060-5. 2010
    ....
  38. ncbi Steroid induction of a peptide hormone gene leads to orchestration of a defined behavioral sequence
    D Zitnan
    Department of Entomology, University of California, Riverside 92521, USA
    Neuron 23:523-35. 1999
    ..The Inka cell provides a model for linking steroid regulation of peptide hormone expression and release with activation of a defined behavioral sequence...
  39. ncbi TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung, Taiwan 404, ROC
    Insect Biochem Mol Biol 42:296-303. 2012
    ..These results suggest that PTTH/PI3K/TOR/4E-BP (S6K) signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in B. mori...
  40. ncbi Male accessory gland proteins induce female monogamy in anopheline mosquitoes
    B Shutt
    Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, UK
    Med Vet Entomol 24:91-4. 2010
    ..Importantly, this also suggests that the rare cases of re-mating following cross-mating observed in this species may not be a form of reproductive barrier between molecular forms...
  41. ncbi Molecular cloning of the Bombyx mori prothoracicotropic hormone
    A Kawakami
    Department of Biology, School of Science, Nagoya University, Japan
    Science 247:1333-5. 1990
    ..In situ hybridization showed the localization of the prepro-PTTH mRNA to two dorsolateral neurosecretory cells of the Bombyx brain...
  42. ncbi Molecular characterization of prothoracicotropic hormone and diapause hormone in Heliothis virescens during diapause, and a new role for diapause hormone
    W H Xu
    Department of Entomology, Ohio State University, Columbus, Ohio, USA
    Insect Mol Biol 12:509-16. 2003
    ..The injection of DH into diapausing pupae did indeed successfully terminate diapause, thus suggesting a possible new role for this neuropeptide...
  43. ncbi Effect of pheromones, hormones, and handling on sucrose response thresholds of honey bees (Apis mellifera L.)
    T Pankiw
    Department of Entomology, Texas A and M University, College Station, TX 77843 2475, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 189:675-84. 2003
    ..Sixty minutes after handling there were no significant treatment differences. We concluded that putative stress effects of handling were blocked by anesthetic...
  44. pmc Bursicon functions within the Drosophila CNS to modulate wing expansion behavior, hormone secretion, and cell death
    Nathan C Peabody
    Laboratory of Molecular Biology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:14379-91. 2008
    ..Our results reveal novel neuromodulatory functions for bursicon and support the hypothesis that the B(SEG) are essential for orchestrating both the behavioral and somatic processes underlying wing expansion...
  45. ncbi Terminal pattern elements in Drosophila embryo induced by the torso-like protein
    J R Martin
    Institut Pasteur, Laboratoire de Biologie Moléculaire de la Drosophile, Paris, France
    Nature 367:741-5. 1994
    ..These results suggest that the tsl protein is the ligand that binds to the torso receptor...
  46. ncbi In vitro and in vivo stimulation of extracellular signal-regulated kinase (ERK) by the prothoracicotropic hormone in prothoracic gland cells and its developmental regulation in the silkworm, Bombyx mori
    Ju Ling Lin
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung 404, Taiwan, ROC
    J Insect Physiol 53:622-31. 2007
    ..These results suggest that development-specific changes in ERK phosphorylation may play a role in PTTH stimulation of ecdysteroidogenesis...
  47. ncbi Complex steroid-peptide-receptor cascade controls insect ecdysis
    D Zitnan
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 84506 Bratislava, Slovakia
    Gen Comp Endocrinol 153:88-96. 2007
    ..2) Release and interaction of Inka cell peptide hormones and multiple central neuropeptides to control consecutive phases of the ecdysis sequence...
  48. ncbi Control of ecdysteroidogenesis in prothoracic glands of insects: a review
    Elisabeth Marchal
    Department of Animal Physiology and Neurobiology, K U Leuven, Naamsestraat 59, 3000 Leuven, Belgium
    Peptides 31:506-19. 2010
    ..both of peptidic and non-peptidic nature are able to affect PG ecdysteroidogenesis, such as the 'classic' insect hormones, juvenile hormone (JH) and the molting hormone (20E) itself...
  49. pmc Peristalsis in the junction region of the Drosophila larval midgut is modulated by DH31 expressing enteroendocrine cells
    Dennis R LaJeunesse
    Department of Biology, 312 Eberhart Bldg, University of North Carolina Greensboro, Greensboro, North Carolina 27402, USA
    BMC Physiol 10:14. 2010
    ..In all intestines, peristaltic action of the gut moves food through the various stages of digestion from the anterior end towards the posterior, with the rate of flow dependent on signals, both intrinsic and extrinsic to the gut itself...
  50. ncbi Distribution of PER protein, pigment-dispersing hormone, prothoracicotropic hormone, and eclosion hormone in the cephalic nervous system of insects
    Radka Zavodska
    Faculty of Pedagogy, University of South Bohemia, Jeronýmova 10, 371 15 Ceské Budejovice, Czech Republic
    J Biol Rhythms 18:106-22. 2003
    ..There are no signs of co-localization of the PER-, PDH-, PTTH-, and EH-like antigens in identical neurons...
  51. pmc Different forces drive the evolution of the Acp26Aa and Acp26Ab accessory gland genes in the Drosophila melanogaster species complex
    M Aguade
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, 08071 Barcelona, Spain
    Genetics 150:1079-89. 1998
    ..Comparison of polymorphism and divergence at synonymous and nonsynonymous sites revealed that directional selection acting on amino acid replacement changes has driven the evolution of the Acp26Aa protein in the last 2.5 myr...
  52. ncbi Cardioacceleratory and myostimulatory activity of allatotropin in Triatoma infestans
    Marcos Sterkel
    Centro Regional de Estudios Genomicos CREG UNLP, Argentina
    Comp Biochem Physiol A Mol Integr Physiol 155:371-7. 2010
    ..Finally, our results suggest that AT interacts with serotonin to facilitate the circulation of haemolymph during post-prandial diuresis...
  53. ncbi The pro-apoptotic action of the peptide hormone Neb-colloostatin on insect haemocytes
    E Czarniewska
    Department of Animal Physiology and Development, Institute of Experimental Biology, Adam Mickiewicz University, Umultowska 89, 61 614 Poznan, Poland
    J Exp Biol 215:4308-13. 2012
    ..This is the first report that exposure to a peptide hormone causes apoptosis in insect haemocytes...
  54. ncbi Allatotropin-like peptide in Malpighian tubules: insect renal tubules as an autonomous endocrine organ
    Maria Soledad Santini
    Centro Regional de Estudios Genomicos CREG, Universidad Nacional de La Plata, Parque Tecnologico Florencio Varela, Buenos Aires, Argentina
    Gen Comp Endocrinol 160:243-9. 2009
    ..While MTs are recognised as the target for several hormones, our results corroborate that they also have the ability to produce and secrete a hormone in an autonomous way...
  55. ncbi Insect gonadotropic peptide hormones: some recent developments
    Mariola Kuczer
    Faculty of Chemistry, University of Wrocław, 14 F Joliot Curie Street, 50 383 Wrocław, Poland
    J Pept Sci 13:16-26. 2007
    ..On the basis of the literature data and the results of our investigations, the structure and biological properties of different groups of peptides are presented...
  56. ncbi Insect allatotropins belong to a family of structurally-related myoactive peptides present in several invertebrate phyla
    Michelle M Elekonich
    Department of Biomedical Sciences and the College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA
    Peptides 24:1623-32. 2003
    ..Finally, we speculate that the myoactive properties of allatotropins are basal and it is likely that the stimulatory action of allatotropins on juvenile hormone synthesis evolved secondarily...
  57. ncbi Neuroendocrine control of larval ecdysis behavior in Drosophila: complex regulation by partially redundant neuropeptides
    Anthony C Clark
    Cornell University, Entomology Department, Ithaca, New York 14853, USA
    J Neurosci 24:4283-92. 2004
    ..We propose that important additional neuropeptides, and additional interactions between known regulators, contribute to the mechanisms underlying insect ecdysis behaviors...
  58. ncbi Amino acid sequence and biological activity of a calcitonin-like diuretic hormone (DH31) from Rhodnius prolixus
    Victoria A Te Brugge
    Department of Biology, University of Toronto at Mississauga, 3359 Mississauga Road, Mississauga, Ontario, Canada, L5L 1C6
    J Exp Biol 211:382-90. 2008
    ..prolixus dorsal vessel and hindgut indicate that Rhopr/Dippu-DH(31) increases the frequency of muscle contractions of both tissues. Second messenger pathways were also investigated for the dorsal vessel and hindgut...
  59. ncbi Molecular cloning of the prothoracicotropic hormone from the tobacco hornworm, Manduca sexta
    Motoko Shionoya
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwanoha 5 1 5, Kashiwa 277 8562, Japan
    Insect Biochem Mol Biol 33:795-801. 2003
    ....
  60. ncbi Biological activity of diuretic factors on the anterior midgut of the blood-feeding bug, Rhodnius prolixus
    Victoria Te Brugge
    Department of Biology, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, Ontario, Canada
    Gen Comp Endocrinol 162:105-12. 2009
    ..All of the factors studied increase the frequency of contractions of the anterior midgut...
  61. pmc Immunostaining for allatotropin and allatostatin-A and -C in the mosquitoes Aedes aegypti and Anopheles albimanus
    Salvador Hernandez-Martinez
    Department of Biological Sciences, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
    Cell Tissue Res 321:105-13. 2005
    ..Only the AS-A antiserum labeled immunoreactive endocrine cells in the midgut. The distribution of the peptides supports the concept that they play multiple regulatory roles in both species...
  62. ncbi Gonadoinhibitory effects of Neb-colloostatin and Neb-TMOF on ovarian development in the mealworm, Tenebrio molitor L
    O Wasielewski
    Department of Zoology, Agricultural University, Poznan, Poland
    Arch Insect Biochem Physiol 64:131-41. 2007
    ..They seem to interfere with vitellogenin production by the fat body as well as with vitellogen uptake by the oocytes through modification of patency...
  63. ncbi Interactions between allatostatins and allatotropin on spontaneous contractions of the foregut of larval Lacanobia oleracea
    H J Matthews
    Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK
    J Insect Physiol 53:75-83. 2007
    ..These results question the need for two structurally different allatostatins that have the same physiological effect on foregut peristalsis in L. oleracea larvae...
  64. ncbi Allatotropin expression during the development of the fourth instar larvae of the kissing-bug Triatoma infestans (Klüg)
    F L Riccillo
    Cátedra de Histología y Embriología Animal FCNyM UNLP, Argentina
    Tissue Cell 42:355-9. 2010
    ..The peptide was also found in open-type cells of the midgut. Finally the presence of allatotropic neurons in the optical lobe of the brain suggests that as in other species, the peptide is related with the control of circadian rhythms...
  65. ncbi Mass spectrometry and characterization of Aedes aegypti trypsin modulating oostatic factor (TMOF) and its analogs
    D Borovsky
    Florida Medical Entomology Laboratory, University of Florida, Vero Beach 32962
    Insect Biochem Mol Biol 23:703-12. 1993
    ..These results indicate that the biosynthesis of trypsin-like enzyme in mosquitoes and other insects may be regulated by sequence-related TMOFs...
  66. ncbi Molecular characterization of a cDNA from the silk moth Bombyx mori encoding Manduca sexta allatotropin peptide
    Cheolin Park
    Department of Biology, Korea University, Seoul
    Zoolog Sci 19:287-92. 2002
    ..Midgut has also a number of allatotropin-immunoreactive cells and nerve fibers. These results will provide valuable information in understanding the AT gene of insects...
  67. ncbi Sequencing and characterization of trypsin modulating oostatic factor (TMOF) from the ovaries of the grey fleshfly, Neobellieria (Sarcophaga) bullata
    D Bylemans
    Zoological Institute, Katholieke Universiteit Leuven, Belgium
    Regul Pept 50:61-72. 1994
    ..The role of Neb-TMOF in controlling egg development and the physiological similarities with Aedes-TMOF are discussed...
  68. ncbi Structure and expression of the gene for the prothoracicotropic hormone of the silkmoth Bombyx mori
    T Adachi-Yamada
    Department of Biology, School of Science, Nagoya University, Japan
    Eur J Biochem 220:633-43. 1994
    ..One Bombyx brain at day 0 of the fifth larval instar contained 2.4-2.8 pg PTTH mRNA, and this amount did not change markedly during larval-pupal development...
  69. ncbi Calcitonin receptor 1 (AedaeGPCRCAL1) hindgut expression and direct role in myotropic action in females of the mosquito Aedes aegypti (L.)
    Hyeogsun Kwon
    Department of Entomology, Texas A and M University, College Station, TX 77843 2475, USA
    Insect Biochem Mol Biol 43:588-93. 2013
    ....
  70. ncbi The roles of central and peripheral eclosion hormone release in the control of ecdysis behavior in Manduca sexta
    R S Hewes
    Department of Zoology, University of Washington, Seattle 98195
    J Comp Physiol A 168:697-707. 1991
    ..5. Antidromic stimulation of the proctodeal nerve stumps following proctodeal nerve removal triggered precocious ecdysis. This result further supports the conclusion that centrally released EH is sufficient to trigger the motor program...
  71. ncbi Cardioacceleratory effects of Manduca sexta allatotropin in the true armyworm moth, Pseudaletia unipuncta
    P M Koladich
    Department of Zoology, University of Toronto, M5S 3G5, Toronto, ON, Canada
    Peptides 23:645-51. 2002
    ..Furthermore, analysis suggests that there are differences in both resting and Manse-AT-stimulated heart rates depending on age and rearing conditions...
  72. ncbi The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo
    D Morisato
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 76:677-88. 1994
    ..We propose that proteolytic processing of the spätzle protein is confined to the ventral side of the embryo and that the localization of processed spätzle determines where the receptor, Toll, is active...
  73. ncbi Manduca sexta prothoracicotropic hormone: evidence for a role beyond steroidogenesis
    Robert Rybczynski
    Department of Biology, CB 3280, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Arch Insect Biochem Physiol 70:217-29. 2009
    ..The data indicate that PTTH indeed plays a role in non-steroidogenic tissues and suggest possible future avenues for determining which cellular processes are being so regulated...
  74. ncbi Molecular cloning and function of ecdysis-triggering hormones in the silkworm Bombyx mori
    Dusan Zitnan
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 84206 Bratislava, Slovakia
    J Exp Biol 205:3459-73. 2002
    ..mori and highlight significant differences in the neuro-endocrine activation of pre-ecdysis and ecdysis behaviours compared with the related moth, Manduca sexta...
  75. ncbi Characterization of the AeaHP gene and its expression in the mosquito Aedes aegypti (Diptera: Culicidae)
    Travis H Stracker
    Department of Entomology, University of Georgia, Athens 30602, USA
    J Med Entomol 39:331-42. 2002
    ..Based on these results, neurosecretory cells and midgut endocrine cells are likely sources of Aea-HPs shown to reach highest hemolymph titer at the same time as host seeking is inhibited in female Ae. aegypti during a reproductive cycle...
  76. ncbi PTTH-stimulated ecdysone secretion is dependent upon tyrosine phosphorylation in the prothoracic glands of Manduca sexta
    Wendy Smith
    Department of Biology, Northeastern University, 433 Richards Hall, 360 Huntington Avenue, Boston, MA 02115, USA
    Insect Biochem Mol Biol 33:1317-25. 2003
    ..These findings point to an important role for a Src-family tyrosine kinase at a very early step in the PTTH signaling pathway, prior to the activation of adenylyl cyclase...
  77. ncbi An in vitro study on regulation of prothoracic gland activity in the early last-larval instar of the silkworm Bombyx mori
    Akira Mizoguchi
    Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    J Insect Physiol 51:871-9. 2005
    ....
  78. ncbi Hormonal control of insect ecdysis: endocrine cascades for coordinating behavior with physiology
    James W Truman
    Department of Biology, University of Washington, Seattle, Washington 98195, USA
    Vitam Horm 73:1-30. 2005
  79. ncbi Effects of classical insect hormones on the expression profiles of a lipase gene from the cotton bollworm (Helicoverpa armigera)
    Yi Peng Sui
    School of Life Sciences, Shandong University, Jinan 250100, Shandong, China
    Insect Mol Biol 17:523-9. 2008
    ..The expression of Ha-lipase could be up-regulated by methoprene and down-regulated by methoxyfenozide (RH-2485) and 20-hydroxyecdysone (20E)...
  80. ncbi Assessment of natural products in the Drosophila melanogaster B(II) cell bioassay for ecdysteroid agonist and antagonist activities
    L Dinan
    Department of Biological Sciences, University of Exeter, Devon, UK
    Cell Mol Life Sci 58:321-42. 2001
    ..Possible reasons for the prevalence of antagonists and for the low potency of the majority of them are discussed...
  81. ncbi PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca(2+)/calmodulin and receptor tyrosine kinase
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung 404, Taiwan, ROC
    J Insect Physiol 56:93-101. 2010
    ....
  82. pmc Conserved and divergent elements in Torso RTK activation in Drosophila development
    Marco Grillo
    Institut de Biologia Molecular CSIC and Institut de Recerca Biomèdica de Barcelona, C Baldiri Reixac 10, 08028 Barcelona, Catalonia, Spain
    Sci Rep 2:762. 2012
    ..A combination of these mechanisms is likely to allow the repeated activation of a single receptor in different contexts...
  83. ncbi Ecdysteroids regulate secretory competence in Inka cells
    T G Kingan
    Department of Entomology University of California, Riverside, CA 92521, USA
    J Exp Biol 203:3011-8. 2000
    ..Our findings suggest that declining ecdysteroid levels permit a late event in transcription, the product of which is downstream of EH receptor activation and cyclic GMP accumulation in the cascade leading to ETH secretion...
  84. ncbi Neuroparsin transcripts as molecular markers in the process of desert locust (Schistocerca gregaria) phase transition
    Ilse Claeys
    Laboratory of Developmental Physiology, Genomics and Proteomics, Department of Animal Physiology and Neurobiology, K U Louvain, Belgium
    Biochem Biophys Res Commun 341:599-606. 2006
    ..We, hereby, present novel scientific evidence for a phase-dependent regulation of these particular peptide hormone encoding transcripts and assign them as possible molecular markers in the process of locust phase transition...
  85. ncbi cDNA cloning and transcript distribution of two different neuroparsin precursors in the desert locust, Schistocerca gregaria
    T Janssen
    Laboratory for Developmental Physiology and Molecular Biology, Zoological Institute, Naamsestraat 59, B-3000 K.U. Leuven, Belgium
    Insect Mol Biol 10:183-9. 2001
    ..Interestingly, the Scg-NPP2 mRNA content proved to be strongly regulated during the reproductive cycle in both adult males and females...
  86. ncbi Analysis of peptides in the brain and corpora cardiaca-corpora allata of the honey bee, Apis mellifera using MALDI-TOF mass spectrometry
    Neil Audsley
    Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK
    Peptides 27:512-20. 2006
    ..No ion signal was detected that would correspond to the hypertrehalosaemic peptide (=Manse-AKH), which has been isolated from the Italian race of the honey bee (A. mellifera ligustica), but not from A. mellifera carnica...
  87. ncbi Quantitative real-time RT-PCR analysis in desert locusts reveals phase dependent differences in neuroparsin transcript levels
    I Claeys
    Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Belgium
    Insect Mol Biol 14:415-22. 2005
    ..This paper provides the first scientific evidence for phase-dependent transcriptional regulation of neuropeptide hormone encoding genes...
  88. ncbi Ecdysteroids, juvenile hormone and insect neuropeptides: Recent successes and remaining major challenges
    Arnold De Loof
    Zoological Institute of the Katholieke Universiteit Leuven, Naamsestraat 59, 3000 Leuven, Belgium
    Gen Comp Endocrinol 155:3-13. 2008
    ..The finding that the prothoracic glands produce an autocrine factor with growth factor-like properties and secrete proteins necessitates a reevaluation of their role in development...
  89. ncbi cDNA cloning and transcript distribution of two novel members of the neuroparsin family in the desert locust, Schistocerca gregaria
    I Claeys
    Laboratory of Developmental Physiology and Molecular Biology, Department of Animal Physiology and Neurobiology, K U Leuven, Belgium
    Insect Mol Biol 12:473-81. 2003
    ..Neuroparsins also display similarities with vertebrate IGFBP...
  90. pmc Adaptive evolution of recently duplicated accessory gland protein genes in desert Drosophila
    Bradley J Wagstaff
    Section of Integrative Biology, University of Texas, Austin, Texas 78712, USA
    Genetics 177:1023-30. 2007
    ..Thus, mating system variation may be associated with adaptive protein divergence as well as with duplication of Acp's in Drosophila...
  91. ncbi Activation of an extracellular signal-regulated kinase (ERK) by the insect prothoracicotropic hormone
    R Rybczynski
    Department of Biology, Coker Hall CB 3280, University of North Carolina at Chapel Hill, 27599 3280, USA
    Mol Cell Endocrinol 184:1-11. 2001
    ..PTTH-stimulated ERK activity may be important for both rapid regulation of ecdysteroid synthesis and for longer-term changes in the size and function of prothoracic gland cells...
  92. ncbi Analogs of Manduca adipokinetic hormone tested in a bioassay and in a receptor-binding assay
    R Ziegler
    Department of Biochemistry and Center for Insect Science, University of Arizona, Tucson 85721, USA
    Peptides 19:481-6. 1998
    ..In the bioassay an inactive concentration of Ala4 M-AKH increased the activity of a half optimal concentration of native M-AKH...
  93. ncbi Identification of a novel prothoracicostatic hormone and its receptor in the silkworm Bombyx mori
    Naoki Yamanaka
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277 8562, Japan
    J Biol Chem 280:14684-90. 2005
    ..All these results suggest that Bommo-myosuppressin functions as a prothoracicostatic hormone and plays an important role in controlling insect development...
  94. ncbi Adipokinetic hormone enhances nodule formation and phenoloxidase activation in adult locusts injected with bacterial lipopolysaccharide
    Graham Goldsworthy
    Department of Biology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
    J Insect Physiol 49:795-803. 2003
    ....
  95. ncbi A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo
    D S Schneider
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Development 120:1243-50. 1994
    ..The purified protein is smaller than the primary translation product of spätzle, suggesting that proteolytic processing of Spätzle on the ventral side of the embryo is required to generate the localized, active form of the protein...
  96. ncbi How flies get their size: genetics meets physiology
    Bruce A Edgar
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, B 2152, Seattle, Washington 98109, USA
    Nat Rev Genet 7:907-16. 2006
    ..However, we still understand little about how size is actually sensed, or how organ-intrinsic size controls interface with whole-body physiology...
  97. ncbi Fraenkel's pupariation factor identified at last
    Peter Verleyen
    Laboratory of Developmental Physiology, Genomics and Proteomics, KU Leuven, B 3000 Louvain, Belgium
    Dev Biol 273:38-47. 2004
    ..Hence, the recently identified G-protein coupled receptors (CG8784, CG8795) for Drosophila pyrokinin-2 might play an important role in puparium formation...
  98. ncbi Peptidomic analysis of the larval Drosophila melanogaster central nervous system by two-dimensional capillary liquid chromatography quadrupole time-of-flight mass spectrometry
    Geert Baggerman
    Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    J Mass Spectrom 40:250-60. 2005
    ..This clearly demonstrates that the two-dimensional capillary LC approach enhances the coverage of the peptidomic analysis...
  99. ncbi A neuropeptide hormone cascade controls the precise onset of post-eclosion cuticular tanning in Drosophila melanogaster
    Monica M Davis
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Development 134:4395-404. 2007
    ..We conclude that the ecdysis hormone cascade acts as a regulatory switch to control the precise onset of tanning by both translational and activational control of TH...
  100. ncbi The developmental basis for allometry in insects
    D L Stern
    Laboratory for Development and Evolution, University Museum of Zoology and Department of Zoology, Downing Street, Cambridge, CB2 3EJ, UK
    Development 126:1091-101. 1999
    ..Advances in our understanding of the mechanisms of allometry will come through the integrated study of whole tissues using techniques from development, genetics, endocrinology and population biology...
  101. ncbi Behavioral actions of neuropeptides in invertebrates: insights from Drosophila
    John Ewer
    Entomology Department, Cornell University, 5130 Comstock Hall, Ithaca, NY 14853, USA
    Horm Behav 48:418-29. 2005
    ..In addition, I discuss more generally approaches that are available in this organism, which make it especially useful for investigating the hormonal control of behavior...

Research Grants30

  1. Circadian control of a behavioral output
    John Ewer; Fiscal Year: 2007
    ..Thus it offers a unique opportunity to elucidate how the activity of the clock is coupled to the mechanism that controls a behavioral output. [unreadable] [unreadable] [unreadable]..
  2. Juvenile hormone action, and crosstalk between juvenile hormone and 20-hydroxyecd
    Jinsong Zhu; Fiscal Year: 2013
    ..Mosquito egg development is governed by alternating peaks of two major insect hormones - juvenile hormone (JH) and 20-hydroxyecdysone (20E)...
  3. REPRODUCTION IN TICKS AND MITES
    James Oliver; Fiscal Year: 1993
    ..experimental alterations of the NSC by tissue transplants, injections, and topical applications of exogenous insect hormones and selected pharmacologically active compounds known to be present in experiments via in vitro synganglia ..
  4. STEROID RECEPTORS AND CNS DEVELOPMENT
    JAMES TRUMAN; Fiscal Year: 2007
    ..5) Use EcR dominant-negative mutations to selectively suppress cytodynamic modules to establish the role of each on growth dynamics and on the final form of the arbor. ..
  5. Novel Genes Involved in Drug Response
    Ruthann Nichols; Fiscal Year: 2002
    ..Ultimately, our research will determine the role of these gene products in mediating the effect of nicotine in humans. ..
  6. HORMONE ACTION ON THE CNS
    JAMES TRUMAN; Fiscal Year: 2009
    ..Understanding these issues is fundamental to normal brain development and for using stem cells to repair brain disease. ..
  7. Regulation of Steroid Hormone Synthesis by MAP Kinases
    Robert Rybczynski; Fiscal Year: 2004
    ..They thus provide a system in which the acute stimulation of steroid synthesis is uncoupled from cell division. ..
  8. CADDMR: a Cell-based Assay for Drug Discovery for Mental Retardation Disorders
    LINDA RESTIFO; Fiscal Year: 2007
    ..The proposed experiments are an important step toward that goal. [unreadable] [unreadable] [unreadable]..
  9. Molecular Analysis of Tsetse Fly Reproduction
    Geoffrey Attardo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. In vitro culture and transformation of Wolbachia from mosquitoes
    Ann Fallon; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. [unreadable] [unreadable]..
  12. Analysis of Mitochondrial Morphology and Function
    DENNIS LA JEUNESSE; Fiscal Year: 2007
    ..As AREA grant, this project has been designed to accommodate the training and education of undergraduate researchers. [unreadable] [unreadable] [unreadable]..
  13. Mechanisms of Steroid-Triggered Programmed Cell Death
    CARL THUMMEL; Fiscal Year: 2009
    ..Finally, our studies provide a foundation for determining how steroids control cell death in humans, with implications for understanding and treating human disease. ..
  14. Hormonal Control of Insect Epidermis
    Lynn Riddiford; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Intracellular transfer of cholesterol in mosquitoes
    Que Lan; Fiscal Year: 2010
    ..The results will also validate the potential of targeting cholesterol metabolism for the development of new strategies to control mosquito populations. ..
  16. Molecular genetics of egg activation and pronuclear function in Drosophila
    MARIANA FEDERICA WOLFNER; Fiscal Year: 2010
    ..Thus, we exploit the powerful genetics of Drosophila to elucidate efficiently the molecules and gene pathways needed to start development in humans. ..
  17. REGULATION OF INSECT JUVENILE HORMONE BIOSYNTHESIS
    LINDA RESTIFO; Fiscal Year: 2001
    ..The study of CYP4C7 is a first and unique opportunity to study the processes by which the corpora allata are turned off. These processes have until now been addressed mostly at the morphological level. ..
  18. ECDYSONE EFFECTS ON MOSQUITO CELL PROLIFERATION
    Ann Fallon; Fiscal Year: 2001
    ..Results of this study will provide novel insights into the effects of 20E on cell growth and proliferation, which are directly relevant to efforts to control vector-borne disease by genetic manipulation of insect vectors. ..
  19. TRANSCRIPTIONAL REGULATION OF BRAIN DEVELOPMENT
    Eric Turner; Fiscal Year: 2002
    ..0 gene locus in transgenic mice. (3) Compare the functional DNA recognition sites of Brn-3.0 to those of other POU proteins expressed in the brain to begin to decipher the transcriptional genetic code of the nervous system. ..
  20. INSECT MODEL FOR STUDY OF THE INSULIN RECEPTOR
    Wendy Smith; Fiscal Year: 2002
    ..Such work will further basic understanding of the early insulin receptor, and be potentially applicable to the development of novel insect control agents. ..
  21. MOSQUITO IMMUNITY FUNCTIONS
    Ann Fallon; Fiscal Year: 2003
    ..The work will include identification of exon-intron organization and recovery of upstream flanking DNA, which will be analyzed for potential regulatory elements. ..
  22. REGULATION OF JUVENILE HORMONE SYNTHESIS
    Barbara Stay; Fiscal Year: 2003
    ....
  23. STEROID REGULATION OF PROGRAMMED CELL DEATH
    CARL THUMMEL; Fiscal Year: 2003
    ..In addition, this study will provide insight into the molecular mechanisms by which systemic hormonal signals are refined into stage- and tissue-specific biological responses during development. ..
  24. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
    ....
  25. SYNTHESIS AND DEGRADATION OF RIBOSOMES IN THE MOSQUITO
    Ann Fallon; Fiscal Year: 2004
    ..These studies provide cloned genes, molecular approaches, and characterization of regulatory processes that can potentially be manipulated to interfere with disease transmission by blood-feeding arthropods. ..
  26. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  27. CONTROL OF CNS DEVELOPMENT BY BRC TRANSCRIPTION FACTORS
    LINDA RESTIFO; Fiscal Year: 2005
    ..Defining molecular pathways between hormonal signals and specific events in brain development should lead to better therapeutic strategies for treating CNS dysfunction due to congenital and acquired disorders. ..
  28. The molecular basis of morphological evolution
    David L Stern; Fiscal Year: 2010
    ..This detailed analysis of gene regulation promises to provide new insights into how gene regulation functions and evolves in natural species to cause possibly adaptive changes in morphology. ..
  29. Identification of circadian clock output genes
    Mark Drapeau; Fiscal Year: 2006
    ..Then, some of these genes will be studied molecularly to determine how they are regulated by the central clock. ..
  30. Control of Pancreas Growth/Development
    Seung Kim; Fiscal Year: 2004
    ..The genetic, molecular and physiologic analyses of Smad2-mediated TGF-beta signaling will add to our understanding of the principles of vertebrate organogenesis, and may lead to new cell-replacement strategies for diabetes mellitus. ..