hypothalamic hormones

Summary

Summary: Hormones isolated from the hypothalamus which exercise control over other organs, primarily the pituitary gland. Well-known members include certain pituitary hormone-releasing hormones and pituitary hormone release inhibiting hormones. Vasopressin and oxytocin which are found in the posterior pituitary may also be secreted by the hypothalamus but are not grouped here (PITUITARY HORMONES, POSTERIOR).

Top Publications

  1. pmc Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
    Oum Kaltoum Hassani
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 106:2418-22. 2009
  2. ncbi Mice lacking melanin-concentrating hormone are hypophagic and lean
    M Shimada
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Nature 396:670-4. 1998
  3. pmc Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
    D S Ludwig
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Clin Invest 107:379-86. 2001
  4. ncbi A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    D Qu
    Elliott P Joslin Research Laboratory, Joslin Diabetes Center, Boston, MA, USA
    Nature 380:243-7. 1996
  5. ncbi Expanding the scales: The multiple roles of MCH in regulating energy balance and other biological functions
    Pavlos Pissios
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocr Rev 27:606-20. 2006
  6. pmc Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat
    Joram D Mul
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e19600. 2011
  7. ncbi The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways
    B E Hawes
    Central Nervous System Cardiovascular Department, Schering Plough Corp Research Institute, Kenilworth, New Jersey 07033, USA
    Endocrinology 141:4524-32. 2000
  8. ncbi Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons
    Tamar Alon
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:389-97. 2006
  9. ncbi A novel avian hypothalamic peptide inhibiting gonadotropin release
    K Tsutsui
    Laboratory of Brain Science, Hiroshima University, Higashi Hiroshima, 739 8521, Japan
    Biochem Biophys Res Commun 275:661-7. 2000
  10. pmc Melanin-concentrating hormone as a mediator of intestinal inflammation
    Efi Kokkotou
    Gastrointestinal Neuropeptide Center and Center for Inflammatory Bowel Disease, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:10613-8. 2008

Research Grants

  1. HYPOTHALAMIC HORMONES IN PANCREATIC CANCER
    Andrew Schally; Fiscal Year: 1991
  2. REPRODUCTIVE EFFECTS OF OXYTOCIN DEFICIENCY
    CHRISTINA LUEDKE; Fiscal Year: 2001
  3. Thyrotrope Proliferation by Thyroid Hormone
    ELI RIDGWAY; Fiscal Year: 2006
  4. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    Lawrence Frohman; Fiscal Year: 1980
  5. REGULATION OF TRH RECEPTOR BIOSYNTHESIS
    Thomas Segerson; Fiscal Year: 1992
  6. ISOLATION/IDENTIFICATION OF A NEW GH RELEASING PEPTIDE
    CYRIL BOWERS; Fiscal Year: 1992
  7. STRESS EFFECTS ON PREGNANCY AND FETAL NORMALCY
    GAIL RIEGLE; Fiscal Year: 1980
  8. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
  9. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
  10. Biology of the NK cell cytolytic activity rhythm
    DIPAK KUMAR SARKAR; Fiscal Year: 2010

Detail Information

Publications255 found, 100 shown here

  1. pmc Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
    Oum Kaltoum Hassani
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 106:2418-22. 2009
    ....
  2. ncbi Mice lacking melanin-concentrating hormone are hypophagic and lean
    M Shimada
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Nature 396:670-4. 1998
    ..Our results show that MCH is a critical regulator of feeding and energy balance which acts downstream of leptin and the melanocortin system, and that deletion of a gene encoding a single orexigenic peptide can result in leanness...
  3. pmc Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance
    D S Ludwig
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Clin Invest 107:379-86. 2001
    ..Heterozygote C57BL/6J mice expressing the transgene showed increased body weight on a standard diet, confirming that MCH overexpression can lead to obesity...
  4. ncbi A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    D Qu
    Elliott P Joslin Research Laboratory, Joslin Diabetes Center, Boston, MA, USA
    Nature 380:243-7. 1996
    ..These findings suggest that MCH participates in the hypothalamic regulation of body weight...
  5. ncbi Expanding the scales: The multiple roles of MCH in regulating energy balance and other biological functions
    Pavlos Pissios
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocr Rev 27:606-20. 2006
    ....
  6. pmc Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat
    Joram D Mul
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e19600. 2011
    ..Thereby it provides a crucial signal by which hypothalamic neural circuits control energy balance and guide limbic brain areas to enhance motivational or incentive-related aspects of food consumption...
  7. ncbi The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways
    B E Hawes
    Central Nervous System Cardiovascular Department, Schering Plough Corp Research Institute, Kenilworth, New Jersey 07033, USA
    Endocrinology 141:4524-32. 2000
    ..The results of this study are the first to clearly demonstrate that the MCH receptor couples to multiple G proteins to mediate several diverse intracellular signaling pathways...
  8. ncbi Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons
    Tamar Alon
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:389-97. 2006
    ..This has implications for the pathogenesis of acquired changes of body weight and might be considered in clinical settings characterized by substantial weight changes later in life...
  9. ncbi A novel avian hypothalamic peptide inhibiting gonadotropin release
    K Tsutsui
    Laboratory of Brain Science, Hiroshima University, Higashi Hiroshima, 739 8521, Japan
    Biochem Biophys Res Commun 275:661-7. 2000
    ..This is the first hypothalamic peptide inhibiting gonadotropin release reported in a vertebrate. We therefore term it gonadotropin-inhibitory hormone (GnIH)...
  10. pmc Melanin-concentrating hormone as a mediator of intestinal inflammation
    Efi Kokkotou
    Gastrointestinal Neuropeptide Center and Center for Inflammatory Bowel Disease, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:10613-8. 2008
    ..Taken together, these results clearly implicate MCH in inflammatory processes in the intestine and perhaps elsewhere...
  11. ncbi Gonadotropin-inhibitory hormone identification, cDNA cloning, and distribution in rhesus macaque brain
    Takayoshi Ubuka
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    J Comp Neurol 517:841-55. 2009
    ..GnIH neurons might thus regulate several neural systems in addition to pituitary gonadotropin release...
  12. ncbi Molecular cloning and functional characterization of MCH2, a novel human MCH receptor
    J Hill
    Departments of Molecular Biology, Bioinformatics, Gene Expression Sciences, Computational and Structural Sciences, and Vascular Biology, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, United Kingdom
    J Biol Chem 276:20125-9. 2001
    ..The discovery of a novel MCH receptor represents a new potential drug target and will allow the further elucidation of MCH-mediated responses...
  13. pmc Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain
    Takayoshi Ubuka
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    Proc Natl Acad Sci U S A 102:3052-7. 2005
    ..Melatonin appears to act directly on GnIH neurons through its receptor to induce GnIH expression. This is the first demonstration, to our knowledge, of a direct action of melatonin on neuropeptide induction in any vertebrate class...
  14. ncbi Neurochemical characterization and sexual dimorphism of projections from the brain to abdominal and subcutaneous white adipose tissue in the rat
    Elaine S Adler
    Department of Physiology, Monash University, Clayton 3800, Victoria, Australia
    J Neurosci 32:15913-21. 2012
    ..In conclusion, the neurochemical substrates that project through polysynaptic pathways to iWAT and rWAT are different in male and female rats, suggesting that metabolic regulation of rWAT and iWAT is sexually dimorphic...
  15. pmc Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone
    Robert M Sears
    Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 30:8263-73. 2010
    ..The current work integrates the hypothalamus into this model, providing biochemical and cellular mechanisms whereby metabolic and limbic signals converge to regulate food intake...
  16. ncbi Distribution of a novel avian gonadotropin-inhibitory hormone in the quail brain
    Kazuyoshi Ukena
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, 739 8521, Higashi Hiroshima, Japan
    Cell Tissue Res 312:73-9. 2003
    ..Thus, GnIH may participate not only in neuroendocrine functions, but also in behavioral and autonomic mechanisms...
  17. ncbi Melanin-concentrating hormone enhances sucrose intake
    Ruka Sakamaki
    International Center for Medical Research, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Mol Med 15:1033-9. 2005
    ..These results indicate that MCH may be an important regulator of sugar intake in normal as well as in obese diabetic animals...
  18. ncbi Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail
    Takayoshi Ubuka
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    Endocrinology 147:1187-94. 2006
    ..To our knowledge, GnIH is the first identified hypothalamic neuropeptide inhibiting reproductive function in any vertebrate class...
  19. ncbi Gonadotropin-inhibitory peptide in song sparrows (Melospiza melodia) in different reproductive conditions, and in house sparrows (Passer domesticus) relative to chicken-gonadotropin-releasing hormone
    G E Bentley
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    J Neuroendocrinol 15:794-802. 2003
    ..In summary, GnIH has the potential to regulate gonadotropin release at more than one level, and its distribution is suggestive of multiple regulatory functions in the central nervous system...
  20. ncbi Developmental changes in gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica) hypothalamo-hypophysial system
    T Ubuka
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Endocrinol 178:311-8. 2003
    ..These results suggest that GnIH begins its function around hatch and acts as a hypothalamic factor to regulate gonadotropin release in the bird...
  21. ncbi Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice
    Satoshi Mashiko
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300 2611, Japan
    Endocrinology 146:3080-6. 2005
    ..These results indicate that MCH has a major role in the development of diet-induced obesity in mice and that a MCH1R antagonist might be a useful candidate as an antiobesity agent...
  22. ncbi Anxiogenesis induced by nitric oxide synthase inhibition and anxiolytic effect of melanin-concentrating hormone (MCH) in rat brain
    M E Monzon
    Laboratorio de Fisiologia, Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba UNC, 5000 Cordoba, Argentina
    Peptides 22:1043-7. 2001
    ..MCH injected in rats pretreated with L-NOARG also was able to revert the anxiogenic effects of L-NOARG in amygdala...
  23. pmc Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus
    X B Gao
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Physiol 533:237-52. 2001
    ....
  24. ncbi Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone
    Akira Gomori
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300 2611, Japan
    Am J Physiol Endocrinol Metab 284:E583-8. 2003
    ..These results suggest that chronic stimulation of the brain MCH system causes obesity in mice and imply that MCH may have a major role in energy homeostasis...
  25. pmc Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy
    Thomas C Thannickal
    Veterans Administration Greater Los Angeles Healthcare System, Neurobiology Research, North Hills, CA 91343, USA
    Sleep 32:993-8. 2009
    ..In this study we examined hypocretin pathology in narcolepsy without cataplexy...
  26. ncbi T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist
    Shiro Takekawa
    Discovery Research Laboratories I, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Ibaraki 300 4293, Tsukuba, Japan
    Eur J Pharmacol 438:129-35. 2002
    ..These results clearly indicate that T-226296 is a novel, orally active and selective MCH receptor antagonist that will be promising for further exploring the physiology and pathophysiology of MCH-SLC-1 signaling...
  27. ncbi Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
    Anthony N van den Pol
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 42:635-52. 2004
    ..Together, these data support the view that MCH neurons may integrate information within the arousal system in favor of energy conservation...
  28. ncbi Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH)
    George E Bentley
    Department of Integrative Biology, University of California, Berkeley, 94720, USA
    Horm Behav 49:550-5. 2006
    ..These data demonstrate direct effects of GnIH upon reproductive physiology and behavior, possibly via separate actions on two forms of GnRH...
  29. ncbi Comparison of melanin-concentrating hormone and hypocretin/orexin mRNA expression patterns in a new parceling scheme of the lateral hypothalamic zone
    Larry W Swanson
    Neuroscience Program, Department of Biological Sciences, University of Southern California, Hedco Neuroscience Building MC 2520, Room 428, 3641 Watt Way, Los Angeles, CA 90089 2520, USA
    Neurosci Lett 387:80-4. 2005
    ....
  30. ncbi Neuropeptides, including neuropeptide Y and melanocortins, mediate lipolysis in murine adipocytes
    Richard L Bradley
    Research Division, Joslin Diabetes Center, Boston, MA, USA
    Obes Res 13:653-61. 2005
    ....
  31. ncbi Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones
    G Burdyga
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Neuroscience 137:1405-15. 2006
    ..Since the melanin-concentrating hormone system is associated with stimulation of food intake this effect of cholecystokinin may contribute to its action as a satiety hormone...
  32. ncbi Characterization of MCH-mediated obesity in mice
    Masahiko Ito
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300 2611, Japan
    Am J Physiol Endocrinol Metab 284:E940-5. 2003
    ..These findings confirm that modulation of energy homeostasis by MCH may play a critical role in the development of obesity...
  33. ncbi Characterization of CART neurons in the rat and human hypothalamus
    C F Elias
    Department of Neurology, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Comp Neurol 432:1-19. 2001
    ..The distribution of CART cell bodies and fibers in the human hypothalamus indicates that CART may also play a role in the regulation of energy homeostasis in humans...
  34. pmc Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals
    Lance J Kriegsfeld
    Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:2410-5. 2006
    ....
  35. ncbi Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders
    Toshiharu Shimazaki
    Medicinal Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, Saitama, Japan
    CNS Drugs 20:801-11. 2006
    ....
  36. pmc Age-related loss of orexin/hypocretin neurons
    B A Kessler
    University of South Carolina School of Medicine, Department of Pharmacology, Physiology and Neuroscience, 6439 Garners Ferry Road Columbia, SC 29208, USA
    Neuroscience 178:82-8. 2011
    ....
  37. pmc Animals models of MCH function and what they can tell us about its role in energy balance
    Pavlos Pissios
    Beth Israel Deaconess Medical Center, Boston, MA 02446, United States
    Peptides 30:2040-4. 2009
    ..Emphasis is given on the discrepancies between the genetic and pharmacologic models of MCHR1 inactivation. We propose some solutions to resolve these discrepancies and discuss some future directions in MCH research...
  38. ncbi Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways
    Pavlos Pissios
    Section on Obesity, Research Division, Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 144:3514-23. 2003
    ..Finally, we provide evidence that such positive interactions are not limited to cell lines but can also be observed in the brain...
  39. ncbi S38151 [p-guanidinobenzoyl-[Des-Gly(10)]-MCH(7-17)] is a potent and selective antagonist at the MCH(1) receptor and has anti-feeding properties in vivo
    Valérie Audinot
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, Croissy sur Seine, France
    Peptides 30:1997-2007. 2009
    ..This is in agreement with the in vitro data and with our previous demonstration of a good correlation between in vitro and in vivo data on MCH(1) agonists...
  40. ncbi Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice
    Timothy J Kowalski
    Department of CV Metabolic Diseases, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 535:182-91. 2006
    ..Acute administration of SCH-A (30 mg/kg) prevented the decrease in energy expenditure associated with food restriction. These results indicate that MCH1 receptor antagonists may be effective in the treatment of obesity...
  41. pmc Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression
    J T Willie
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 8584, USA
    Neuroscience 156:819-29. 2008
    ..When combined with caloric restriction, the treatment of healthy, obese subjects with this compound resulted in some subjects experiencing vivid dreams and sleep disturbances...
  42. ncbi Effects on sleep of melanin-concentrating hormone (MCH) microinjections into the dorsal raphe nucleus
    Patricia Lagos
    Departamento de Fisiologia, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Brain Res 1265:103-10. 2009
    ..We therefore conclude that the hypothalamic MCHergic system, via its action in the DR, plays an important role in the generation and/or maintenance of the states of sleep...
  43. ncbi Melanin-concentrating hormone (MCH) modifies memory retention in rats
    M E Monzon
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina
    Peptides 20:1517-9. 1999
    ..From these results, it seems that MCH modulates memory early after training by acting on both the amygdala and hippocampus and, 4 h after training, on the hippocampus...
  44. pmc Comparison of melanin-concentrating hormone and hypocretin/orexin peptide expression patterns in a current parceling scheme of the lateral hypothalamic zone
    Joel D Hahn
    Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2520, USA
    Neurosci Lett 468:12-7. 2010
    ....
  45. ncbi The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus
    J L Nahon
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, San Diego, California 92138 9216
    Endocrinology 125:2056-65. 1989
    ..Our results explain the staining of a discrete population of dorso-lateral hypothalamic neurons by heretofore seemingly unrelated antisera and provide evidence for the production of multiple novel neuropeptides from a common precursor...
  46. ncbi Microinjection of the melanin-concentrating hormone into the lateral basal forebrain increases REM sleep and reduces wakefulness in the rat
    Patricia Lagos
    Department of Physiology, School of Medicine, Montevideo 11800, Uruguay
    Life Sci 90:895-9. 2012
    ....
  47. ncbi MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance
    Justin Y Jeon
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabetes 55:428-34. 2006
    ..In contrast, expression of Sir2 was unchanged. In aggregate, these findings suggest that MCH ablation improves the long-term outcome for several indicators of the aging process...
  48. ncbi Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity
    Yanyun Chen
    Division of Endocrinology, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Endocrinology 143:2469-77. 2002
    ..Our data firmly establish MCHR1 as a mediator of MCH effects on energy homeostasis and suggest that inactivation of MCHR1 alone is capable to counterbalance obesity induced by a high-fat diet...
  49. ncbi The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance
    Dan Georgescu
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
    J Neurosci 25:2933-40. 2005
    ..This work identifies a novel hypothalamic-AcSh circuit that influences appetitive behavior and mediates the antidepressant activity of MCH1R antagonists...
  50. ncbi Melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity
    Anthony L Handlon
    Metabolic and Viral Center of Excellence for Drug Discovery, GlaxoSmithKline, P O Box 13398, Research Triangle Park, North Carolina 27709 3398, USA
    J Med Chem 49:4017-22. 2006
  51. ncbi Role of the melanin-concentrating hormone neuropeptide in sleep regulation
    Christelle Peyron
    UMR CNRS, Universite Claude Bernard Lyon1, Universite de Lyon, Institut Federatif des Neurosciences de Lyon, France
    Peptides 30:2052-9. 2009
    ....
  52. ncbi Melanin concentrating hormone increase hippocampal synaptic transmission in the rat
    Mariana Varas
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, 5000, Cordoba, Argentina
    Peptides 23:151-5. 2002
    ..We cannot rule out other MCH neurochemical mechanism and other areas of the brain involved in the MCH effects...
  53. ncbi Human immune cells express ppMCH mRNA and functional MCHR1 receptor
    Myriam Verlaet
    Center for Cellular and Molecular Neurobiology, University of Liege, 17 Place Delcour, B 4020, Liege, Belgium
    FEBS Lett 527:205-10. 2002
    ..Moreover, MCH treatment decreases the CD3-stimulated PBMC proliferation in vitro. Accordingly, our data indicate for the first time that MCH and MCHR1 may exert immunomodulatory functions...
  54. ncbi Similarities in cellular expression and functions of melanin-concentrating hormone and atrial natriuretic factor in the rat digestive tract
    G Hervieu
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre Nationale de la Recherche Scientifique Unité Propre de Recherche 411, Valbonne, France
    Endocrinology 137:561-71. 1996
    ..These studies strongly suggest that MCH produced by antigen-presenting cells of the lamina propria may have an important role, similar to that of ANF at the colonic level, in the physiology of the GI tract...
  55. ncbi Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice
    Daniel G Smith
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuropsychopharmacology 31:1135-45. 2006
    ..Distinct behavioral, physiological, and neurochemical stress, and anxiety-related responses were selectively modulated by the MCHR1, and these actions may involve corticolimbic regulation of stress responsivity and anxiety...
  56. ncbi Melanin-concentrating hormone facilitates migration of preadipocytes
    Laurie B Cook
    Department of Biology, The College at Brockport, State University of New York, 350 New Campus Drive, Brockport, NY 14420, USA
    Mol Cell Endocrinol 320:45-50. 2010
    ..We conclude that MCH could influence the expansion of adipose tissue through its ability to enhance preadipocyte migration...
  57. ncbi Involvement of specific orexigenic neuropeptides in sweetener-induced overconsumption in rats
    Yuichi Furudono
    Department of Behavioral Physiology, Graduate School of Human Sciences, Osaka University, 1 2 Yamadaoka, Suita 565 0871, Japan
    Behav Brain Res 175:241-8. 2006
    ....
  58. pmc Activation of the basal forebrain by the orexin/hypocretin neurones
    E Arrigoni
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Acta Physiol (Oxf) 198:223-35. 2010
    ..In addition, orexins and dynorphin may act synergistically in the BF to promote arousal and improve cognitive performance...
  59. ncbi Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1
    J Chambers
    Department of Molecular Screening Technologies, New Frontiers Science Park, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK
    Nature 400:261-5. 1999
    ..We also show that SLC-1 messenger RNA and protein is expressed in the ventromedial and dorsomedial nuclei of the hypothalamus, consistent with a role for SLC-1 in mediating the effects of MCH on feeding...
  60. ncbi Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance
    H Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Neuroscience 135:611-25. 2005
    ..Projections to ventral medullary sites may play a role in the inhibitory effect of melanin-concentrating hormone on energy expenditure...
  61. pmc Melanin-concentrating hormone depresses L-, N-, and P/Q-type voltage-dependent calcium channels in rat lateral hypothalamic neurons
    Xiao Bing Gao
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Physiol 542:273-86. 2002
    ..The attenuation of calcium currents is consistent with an inhibitory action for the peptide in neurons...
  62. ncbi Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers
    J C Bittencourt
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508 900, SP, Brazil
    Brain Res 805:1-19. 1998
    ..Potential autonomic and behavioral roles of the NEI and MCH systems in the MS/DBC and the SpCd are discussed...
  63. pmc A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
    Laure Verret
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    BMC Neurosci 4:19. 2003
    ..Next, we compared the effect of MCH and NaCl intracerebroventricular (ICV) administrations on sleep stage quantities to further determine whether MCH neurons play an active role in PS regulation...
  64. ncbi Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors
    Mandana Modirrousta
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Eur J Neurosci 21:2807-16. 2005
    ..On the other hand, under certain conditions, Orx neurons may also be submitted to an inhibitory influence by NA through alpha2-ARs...
  65. ncbi Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes
    Richard L Bradley
    Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Endocrinol Metab 283:E584-92. 2002
    ..These results provide further evidence for a functional MCH signaling pathway in adipocytes...
  66. pmc Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists
    Shinjae Chung
    Department of Pharmacology, University of California, 369 Med Surge II, Irvine, CA 92612, USA
    J Mol Neurosci 43:115-21. 2011
    ..This will help us understand the physiological functions of the MCH system and suggest some of the potential applications of MCH1R antagonists in human disorders...
  67. ncbi Melanin concentrating hormone is a novel regulator of islet function and growth
    Pavlos Pissios
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabetes 56:311-9. 2007
    ..Together, these data provide novel evidence for an autocrine role for MCH in the regulation of beta-cell mass dynamics and in islet secretory function and suggest that MCH is part of a hypothalamic-islet (pancreatic) axis...
  68. ncbi Pmch expression during early development is critical for normal energy homeostasis
    Joram D Mul
    Hubrecht Institute Koninklijke Nederlandse Akademie van Wetenschappen and University Medical Center Utrecht, The Netherlands
    Am J Physiol Endocrinol Metab 298:E477-88. 2010
    ....
  69. ncbi Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices
    L Bayer
    Département de Neurosciences Fondamentales, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet 1211, Geneve 4, Switzerland
    Neuroscience 130:807-11. 2005
    ....
  70. pmc Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically
    Sarah Stanley
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:7024-9. 2010
    ..The delineation of this circuitry will facilitate a functional analysis of the possible role of these potential command-like neurons to modulate autonomic outflow and coordinate metabolic responses in liver and adipose tissue...
  71. ncbi GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle
    Romain Goutagny
    CNRS, UMR 5167, Faculte de Medecine, RTH Laennec, 7 rue G Paradin, 69372 Lyon Cedex 08, France
    Neuroreport 16:1069-73. 2005
    ..These results suggest that neurons containing melanin-concentrating hormone are not active during waking and that the lack of a potent GABAergic influence during waking is consistent with their role in sleep regulation...
  72. ncbi Hypocretin (orexin) cell loss in Parkinson's disease
    Thomas C Thannickal
    Department of Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Brain 130:1586-95. 2007
    ....
  73. ncbi Regulation of adaptive behaviour during fasting by hypothalamic Foxa2
    Jose P Silva
    The Rockefeller University, Laboratory of Metabolic Diseases, 1230 York Avenue, New York, New York 10021, USA
    Nature 462:646-50. 2009
    ..Our results demonstrate that Foxa2 can act as a metabolic sensor in neurons of the lateral hypothalamic area to integrate metabolic signals, adaptive behaviour and physiological responses...
  74. pmc The melanin-concentrating hormone system modulates cocaine reward
    Shinjae Chung
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:6772-7. 2009
    ..Thus, the MCH system has an important modulatory role in cocaine reward and reinforcement by potentiating the dopaminergic system in the NAcSh, which may provide a new rationale for treating cocaine addiction...
  75. ncbi Characterization of subpopulations of neurons producing melanin-concentrating hormone in the rat ventral diencephalon
    Vesna Cvetkovic
    Laboratoire d Histologie, IFR 133, Faculte de Medecine et de Pharmacie, Besancon, France
    J Neurochem 91:911-9. 2004
    ..Thus, at least two subpopulations of MCH neurons can be distinguished on the basis of neuronal phenotypes and connections. These neurons may be involved in distinct circuitry and in distinct functions...
  76. ncbi Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats
    Lucie Hanriot
    Centre National de Recherche Scientifique UMR5167, Universite de Lyon, Université Lyon1, Institut Federatif des Neurosciences de Lyon, Lyon, 69372, France
    J Comp Neurol 505:147-57. 2007
    ..Based on these results and the literature, we propose that MCH could be involved in memory processes and in the inhibition of muscle tone during PS...
  77. ncbi A novel G protein-coupled receptor for gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica): identification, expression and binding activity
    H Yin
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Endocrinol 184:257-66. 2005
    ..These results suggest that GnIH acts directly on the pituitary via GnIH receptor to inhibit gonadotropin release. GnIH may also act on the hypothalamus to inhibit gonadotropin-releasing hormone release...
  78. ncbi Melanin-concentrating hormone induces neurite outgrowth in human neuroblastoma SH-SY5Y cells through p53 and MAPKinase signaling pathways
    Natacha Cotta-Grand
    The Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique and Université Nice Sophia Antipolis, Valbonne, France
    Peptides 30:2014-24. 2009
    ..Collectively, our results provide the first evidence for a role of MCH in neuronal differentiation of endogenously MCH-R1-expressing cells via non-exclusive MAPKinase and p53 signaling pathways...
  79. ncbi Molecular characterization of the melanin-concentrating-hormone receptor
    Y Saito
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nature 400:265-9. 1999
    ....
  80. ncbi Pro-melanin concentrating hormone messenger ribonucleic acid and peptides expression in peripheral tissues of the rat
    G Hervieu
    Institut de Pharmacologie Moleculaire et Cellulaire, UPR 411 CNRS, Universite de Nice Sophia Antipolis, Valbonne, France
    Neuroendocrinology 61:348-64. 1995
    ..The cellular location suggests that MCH and associated peptides may play a role in spermatogenesis and in digestive processes...
  81. ncbi Expression of melanin-concentrating hormone receptors in insulin-producing cells: MCH stimulates insulin release in RINm5F and CRI-G1 cell-lines
    M Tadayyon
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, CM19 5AD, United Kingdom
    Biochem Biophys Res Commun 275:709-12. 2000
    ..The data provide evidence for the expression of MCH receptors in insulin producing cells. The insulinotropic effect of MCH may contribute to the regulation of metabolism and energy balance by this peptide...
  82. ncbi Melanin-concentrating hormone stimulates the release of luteinizing hormone-releasing hormone and gonadotropins in the female rat acting at both median eminence and pituitary levels
    S R Chiocchio
    Instituto de Neurobiologia, Buenos Aires 1414, Argentina
    Biol Reprod 64:1466-72. 2001
    ..Simultaneous incubation of pituitaries with MCH and LHRH did not modify LH but increased the FSH release induced by LHRH. The present results suggest that MCH could be involved in the regulation of preovulatory gonadotropin secretion...
  83. ncbi The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor
    P M Lembo
    AstraZeneca R and D Montreal, Quebec, Canada
    Nat Cell Biol 1:267-71. 1999
    ..Our identification of an MCH receptor could have implications for the development of new anti-obesity therapies...
  84. ncbi Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons
    Stephanie Dallvechia-Adams
    Division of Neuroscience, Yerkes Regional Primate Research Center, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    J Comp Neurol 448:360-72. 2002
    ..Results of these studies suggest that the most significant behavioral states influenced by CART peptides, feeding and locomotion, may be mediated by direct and/or indirect modulation of VTA dopaminergic neuronal activity...
  85. ncbi The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
    B J Oldfield
    Howard Florey Institute, University of Melbourne, VIC Australia
    Neuroscience 110:515-26. 2002
    ..These data provide part of an anatomical framework which subserves the regulation of energy expenditure...
  86. ncbi Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
    Beth Borowsky
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey, USA
    Nat Med 8:825-30. 2002
    ..Given these observations, an MCH1-R antagonist may be useful not only in the management of obesity but also as a treatment for depression and/or anxiety...
  87. ncbi Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor
    Y Shimomura
    Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, Ibaraki, 300 4293, Japan
    Biochem Biophys Res Commun 261:622-6. 1999
    ..2 nM for both the rat and human SLC-1 receptors. This is the first description of the functional receptor for MCH...
  88. ncbi Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats
    O Della-Zuana
    Division of Metabolic Diseases, Servier Research Institute, Suresnes, France
    Int J Obes Relat Metab Disord 26:1289-95. 2002
    ..Therefore, the acute effects of MCH on food intake and the chronic effect of MCH on food intake and the gene expression of various hypothalamic peptides involved in the control of appetite were studied in rats...
  89. ncbi Response to novelty after i.c.v. injection of melanin-concentrating hormone (MCH) in rats
    M E Monzon
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Argentina
    Physiol Behav 67:813-7. 1999
    ..The data indicate that MCH exerts an anxiolytic effect, and suggests a physiological role for this...
  90. ncbi Effects of MCH and a MCH1-receptor antagonist on (palatable) food and water intake
    Céline Morens
    Department of Neuroendocrinology, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Brain Res 1062:32-8. 2005
    ..In conclusion, our results point to an involvement of endogenous MCH in the enhanced intake of palatable food. Furthermore, they confirm that MCH stimulates not only food intake but also water intake...
  91. ncbi Birth of two chimeric genes in the Hominidae lineage
    A Courseaux
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR CNRS 6097, 660 route des Lucioles Sophia Antipolis 06560 Valbonne, France
    Science 291:1293-7. 2001
    ..The RNA expression patterns of those chimeric genes suggest that they have been submitted to strong regulatory constraints during primate evolution...
  92. ncbi Emergence of a brain-expressed variant melanin-concentrating hormone gene during higher primate evolution: a gene "in search of a function"
    A Viale
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Valbonne, France
    Mol Biol Evol 15:196-214. 1998
    ....
  93. ncbi Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone
    Caroline R Abbott
    Endocrine Unit, Imperial College London, Hammersmith Campus, London W12 ONN, United Kingdom
    Endocrinology 144:3943-9. 2003
    ..0 fmol/explant; P < 0.001). These studies suggest that the orexigenic effect of MCH may be mediated via activation or inhibition of these feeding circuits within the arcuate nucleus and paraventricular nucleus of the hypothalamus...
  94. ncbi Intracerebroventricular administration of melanin-concentrating hormone suppresses pulsatile luteinizing hormone release in the female rat
    H Tsukamura
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    J Neuroendocrinol 12:529-34. 2000
    ..Take together, these results raise the possibility that MCH could play a role in mediating the suppression of LH secretion during periods of reduced nutrition...
  95. ncbi Effects of intracerebroventricular and intra-accumbens melanin-concentrating hormone agonism on food intake and energy expenditure
    Benjamin Guesdon
    Centre de Recherche de l Hôpital Laval et Centre de Recherche sur le Métabolisme Energétique de l Université Laval, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 296:R469-75. 2009
    ..The present results further delineate the influence of MCH on energy expenditure and substrate oxidation while confirming the key role of the NAcSH in the effects of the MCH system on food intake...
  96. ncbi MCH and feeding behavior-interaction with peptidic network
    B Griffond
    Universite de Franche Comte, Besancon, France
    Peptides 30:2045-51. 2009
    ....
  97. ncbi Structure and expression of the variant melanin-concentrating hormone genes: only PMCHL1 is transcribed in the developing human brain and encodes a putative protein
    A Viale
    Institut de Pharmacologie Moléculaire et Cellullaire, UPR 411 Centre National de la Recherche Scientifique, Valbonne, France
    Mol Biol Evol 17:1626-40. 2000
    ....
  98. ncbi Characterization of melanin-concentrating hormone from rat hypothalamus
    J M Vaughan
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, San Diego, California 92138 9216
    Endocrinology 125:1660-5. 1989
    ..Rat MCH has the following primary structure: Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln- Val...
  99. ncbi Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus
    N A Tritos
    Elliot P Joslin Laboratory, Joslin Diabetes Center, Rm 653, One Joslin Place, Boston, MA 02215, USA
    Brain Res 895:160-6. 2001
    ..This conclusion is further supported by the observation that orexin ablated mice have arousal and not feeding deficits...
  100. ncbi Hypothalamic hormones a.k.a. hypothalamic releasing factors
    Roger Guillemin
    Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
    J Endocrinol 184:11-28. 2005
    ..This review will be composed of brief essays on current knowledge of each of the original 'hypothalamic hormones', TRH, GnRH, somatostatin, GHRH and corticotropin releasing hormone and will close on possible and ..
  101. ncbi Cell and molecular cell biology of melanin-concentrating hormone
    Bernadette Griffond
    Laboratoire d Histologie, Faculte de Medecine, Place St Jacques, Besancon, France
    Int Rev Cytol 213:233-77. 2002
    ..Evidence that MCH also has peripheral paracrine/autocrine effects in mammals is provided...

Research Grants54

  1. HYPOTHALAMIC HORMONES IN PANCREATIC CANCER
    Andrew Schally; Fiscal Year: 1991
    Analogs of hypothalamic hormones somatostatin and luteinizing hormone-releasing hormone (LH-RH) given alone or in combination will be tested in rat and hamster models of transplanted acinar and ductal pancreatic carcinomas and in nude ..
  2. REPRODUCTIVE EFFECTS OF OXYTOCIN DEFICIENCY
    CHRISTINA LUEDKE; Fiscal Year: 2001
    ..characterization, verifying the absence of oxytocin production and the integrity of synthesis of other hypothalamic hormones. Growth will be evaluated by comparison with wild-type littermates from heterozygote matings...
  3. Thyrotrope Proliferation by Thyroid Hormone
    ELI RIDGWAY; Fiscal Year: 2006
    ..Thyrotrope cell function is, in turn, regulated by hypothalamic hormones (TRH and SRIF) and the circulating levels of thyroid hormones (T3 and T4)...
  4. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    Lawrence Frohman; Fiscal Year: 1980
    ..A study of the biosynthesis of specific hypothalamic hormones is being conducted in normal and neoplastic tissue and evidence for heterogeneity of releasing factors in ..
  5. REGULATION OF TRH RECEPTOR BIOSYNTHESIS
    Thomas Segerson; Fiscal Year: 1992
    ..A better understanding of TRH-induced cellular events should provide important information about neuronal control of pituitary function and the functional diversity of hypothalamic hormones.
  6. ISOLATION/IDENTIFICATION OF A NEW GH RELEASING PEPTIDE
    CYRIL BOWERS; Fiscal Year: 1992
    ..utilization of conventional chromatography techniques and schemes well established for the isolation of hypothalamic hormones along with established highly sensitive in vitro and in vivo bioassays to detect the activity of the ..
  7. STRESS EFFECTS ON PREGNANCY AND FETAL NORMALCY
    GAIL RIEGLE; Fiscal Year: 1980
    ..In addition, we are measuring the effect of sex steroids and stress on hypothalamic neurotransmitters which are believed to regulate the secretion of hypothalamic hormones which regulate pituitary function.
  8. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
    ..abstract_text> ..
  9. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
  10. Biology of the NK cell cytolytic activity rhythm
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..The proposed series of studies should enhance our knowledge of the physiological mechanisms orchestrating NK cell circadian function. ..
  11. Bio-Psych Stress Measure Associations and Preterm Birth
    Gwen Latendresse; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Behavioral Mechanisms of CNS Melanocortin Action
    Stephen Benoit; Fiscal Year: 2007
    ..These results will expand our understanding of this critical system for the regulation of food intake and body weight and, hopefully, provide insight into important structures and systems that are downstream of the melanocortins. ..
  13. Syndecan & CNS Melanocortin Signaling in Energy Balance
    Stephen Benoit; Fiscal Year: 2007
    ..The results may provide important, basic insights into the control of body weight by the central melanocortin system and its recently identified co-receptor, syndecan-3. ..
  14. Mechanisms of Leptin Signaling in the Hypothalamus
    Abhiram Sahu; Fiscal Year: 2007
    ..These studies will further our understanding of leptin signaling in the hypothalamus in relation to feeding, and therefore will be relevant to the development of therapeutic approaches to eating disorders. [unreadable] [unreadable]..
  15. Metabolic Regulation of Reproduction
    GREGORY FRALEY; Fiscal Year: 2006
    ..It is hoped that this basic knowledge will lead to a better understanding of disorders of reproduction that are associated with diabetes and thus provide an enlightened path towards their treatment. ..
  16. Mechanisms of Inhibitory Glycine Receptor Modulation
    KWEE THIO; Fiscal Year: 2006
    ..abstract_text> ..
  17. Fetal Alcohol Effects on Circadian clocks and POMC
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..This information should help to develop therapeutic strategies in managing sleep-wake disturbances and the resultant health consequences in FAE offspring. ..
  18. Leptin As A Novel Neurohormonal Anticonvulsant
    KWEE THIO; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. Nutritional and Hormonal Determinants of Peak Bone Mass
    Madhusmita Misra; Fiscal Year: 2008
    ..The effects of estrogen in weight recovered vs. non-weight recovered AN will also be studied. ..
  20. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2008
    ..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  21. Cytomegalovirus in the Brain
    Anthony N van den Pol; Fiscal Year: 2010
    ..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
  22. Prenatal alcohol: Hormone-regulated genes and behavior
    Eva E Redei; Fiscal Year: 2010
    ..We anticipate that T4 treatment protocols successful in the animal model of FAE can potentially be implemented in clinical trials. ..
  23. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
    ....
  24. Hypocretin Neurons
    Anthony N van den Pol; Fiscal Year: 2010
    ..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..
  25. A Mature Brain Architecture Knowledge Management System
    LARRY SWANSON; Fiscal Year: 2008
    ..abstract_text> ..
  26. Crosstalk of hypocretin and MCH in feeding regulation
    Xiao Bing Gao; Fiscal Year: 2010
    ..Ultimately, we hope that our research will benefit those suffering from obesity and obesity-related diseases. ..
  27. Molecular markers of chronic stress vulnerability/resilience
    Eva Redei; Fiscal Year: 2008
    ..These scenarios would allow us to identify candidate markers of chronic stress from the blood representing an accessible source of genetic material in humans. [unreadable] [unreadable] [unreadable]..
  28. Regulation of Hypothalamic Sleep-wake Neuronal System
    NOOR ALAM; Fiscal Year: 2008
    ..This will contribute to the search for more targeted and specific therapeutic strategies for sleep disorders. ..
  29. Bisphenol-A and the Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2008
    ..The findings will be relevant to research on fetal origin of infertility and the threat estrogenic environmental disruptors at current exposure levels pose to human health. ..
  30. Melanin-Concentrating Hormone and Alcohol Intake
    Elizabeth Duncan; Fiscal Year: 2005
    ..The specific aims are: 1) To test the hypothesis that MCH is an endogenous factor regulating alcohol consumption and, 2) To test the hypothesis that MCH regulates the motivation to consume alcohol by modulating its reward properties. ..
  31. Mechanisms of Energy Balance in the Adipocyte
    Richard Bradley; Fiscal Year: 2005
    ..abstract_text> ..
  32. NO AND THE MAGNOCELLULAR NEUROENDOCRINE SYSTEM
    MASSAKO KADEKARO KUTYNA; Fiscal Year: 2002
    ....
  33. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2002
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  34. BROWN FAT AND THE CENTRAL CONTROL OF ENERGY BALANCE
    JEFFREY FLIER; Fiscal Year: 2002
    ..In the fourth aim, the investigators will use transgenic and gene targeting approaches involving several of these genes to ask questions about the mechanisms by which they function together to regulate energy balance. ..
  35. Molecular Pathophysiology of Human Growth Disorders
    MICHAEL WAJNRAJCH; Fiscal Year: 2002
    ....
  36. Narp Expression and Drugs of Abuse
    Irving Reti; Fiscal Year: 2002
    ..B) Develop methods to manipulate expression of Narp in the VTA using the herpes simplex virus vector system. ..
  37. OPIOID AND ALCOHOL REGULATED IMMUNE FUNCTION
    DIPAK SARKAR; Fiscal Year: 2002
    ....
  38. CONSTRUCTION OF BIOLOGY RESEARCH FACILITY
    DIPAK SARKAR; Fiscal Year: 2002
    ..abstract_text> ..
  39. NEUROENDOCRINE CONTROL OF FSH
    Vasantha Padmanabhan; Fiscal Year: 2001
    ....
  40. LEPTIN ACTION ON HYPOTHALAMIC PEPTIDES GOVERNING FEEDING
    Abhiram Sahu; Fiscal Year: 2001
    ..These studies will further our understanding of leptin signaling in the hypothalamus in relation to feeding, and therefore will be relevant to the development of therapeutic approaches to eating disorders. ..
  41. Role of CNS Insulin in Learning and Memory
    Stephen Benoit; Fiscal Year: 2003
    ..Ultimately, this line of investigation may offer novel therapeutic strategies for treating individuals with cognitive disorders such as Alzheimer' s disease. ..
  42. QTL ANALYSIS OF DEPRESSIVE, STRESS HYPERREACTIVE BEHAVIO
    Eva Redei; Fiscal Year: 2003
    ..We hypothesize that the characterization of QTL and candidate genes in this animal model will facilitate the identification of depression-related genes in humans. ..
  43. CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS
    LARRY SWANSON; Fiscal Year: 2005
    ..abstract_text> ..
  44. Reproductive Consequences of Prenatal Androgenization
    Vasantha Padmanabhan; Fiscal Year: 2005
    ..Specifically it will establish that discrete, experimentally induced androgen excess of fetal sheep provides the first clear etiology for hyperandrogenic anovulation in adulthood. ..
  45. NPY elicits meal-anticipatory responses
    DEBORAH DRAZEN; Fiscal Year: 2005
    ....
  46. MCH Modulation of Neurotransmission in the LH area
    Xiao Bing Gao; Fiscal Year: 2005
    ..The funding of this research proposal is important for the applicant to continue this course. A career development plan is also documented in this proposal. ..
  47. REGULATION OF CNS SYNAPTIC TRANSMISSION BY MGLURS
    JOEL GALLAGHER; Fiscal Year: 2001
    ..Together these data may provide evidence for the use of a novel group of drugs in the treatment of schizophrenia. ..
  48. Exploration of KCC2: Role in Schizophrenia
    JOEL GALLAGHER; Fiscal Year: 2004
    ..Results from the proposed study may provide an impetus to consider a novel pathogenesis for schizophrenia, while at the same time providing a basis for a more effective pharmacotherapy. ..
  49. CONTROL OF SLEEP AND AROUSAL
    NOOR ALAM; Fiscal Year: 2003
    ..These pharmacological manipulations and analytical procedures will help understanding of the adenosinergic and GABAergic mechanisms that shape the discharge patterns of the MBF neurons across the sleep-waking cycle. ..
  50. CORTICOTROPIN RELEASING FACTOR MECHANISMS AND COCAINE
    JOEL GALLAGHER; Fiscal Year: 2003
    ..These results may also provide critical information regarding non-peptide and peptide antagonists of CRF as potentially effective pharmacotherapies in the treatment of chronic cocaine dependence. ..
  51. ESTROGEN MITOGENIC ACTION IN THE PITUITARY
    DIPAK SARKAR; Fiscal Year: 2003
    ..Such knowledge should be important in understanding prolactinoma because increased proliferation is an early step in cell transformation. ..
  52. Antiapoptotic Activity of Alzheimer Abeta
    Craig Atwood; Fiscal Year: 2003
    ..We also will test whether oxidative stress induces neurons to re-enter the cell cycle as a mechanism leading to cell death. ..
  53. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK SARKAR; Fiscal Year: 2009
    ....