follicle stimulating hormone

Summary

Summary: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.

Top Publications

  1. ncbi Effects of transdermal testosterone application on the ovarian response to FSH in poor responders undergoing assisted reproduction technique--a prospective, randomized, double-blind study
    N Massin
    Reproductive Medicine Unit, Jean Verdier Hospital, University Paris XIII, Bondy, France
    Hum Reprod 21:1204-11. 2006
  2. pmc The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?
    Norbert Gleicher
    Center for Human Reproduction, New York, New York, USA
    Reprod Biol Endocrinol 9:116. 2011
  3. ncbi AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis
    S L Broer
    Department of Reproductive Medicine and Gynecology, University Medical Center, GA Utrecht, The Netherlands
    Hum Reprod Update 17:46-54. 2011
  4. ncbi Anti-Müllerian hormone: a new marker for ovarian function
    Jenny A Visser
    Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Reproduction 131:1-9. 2006
  5. ncbi Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve
    I A J van Rooij
    Department of Reproductive Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, Netherlands
    Hum Reprod 17:3065-71. 2002
  6. ncbi Serum anti-Müllerian hormone and FSH: prediction of live birth and extremes of response in stimulated cycles--implications for individualization of therapy
    Scott M Nelson
    Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Hum Reprod 22:2414-21. 2007
  7. ncbi Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males
    Waljit S Dhillo
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 90:6609-15. 2005
  8. ncbi Regulation of ovarian function: the role of anti-Müllerian hormone
    Alexandra L L Durlinger
    Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Reproduction 124:601-9. 2002
  9. ncbi Follicle stimulating hormone-induced growth promotion and gene expression profiles on ovarian surface epithelial cells
    Qing Ji
    Department of Pathology, Olive View UCLA Medical Center, Sylmar, CA, USA
    Int J Cancer 112:803-14. 2004
  10. ncbi Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization
    JoAnne S Richards
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Recent Prog Horm Res 57:195-220. 2002

Detail Information

Publications389 found, 100 shown here

  1. ncbi Effects of transdermal testosterone application on the ovarian response to FSH in poor responders undergoing assisted reproduction technique--a prospective, randomized, double-blind study
    N Massin
    Reproductive Medicine Unit, Jean Verdier Hospital, University Paris XIII, Bondy, France
    Hum Reprod 21:1204-11. 2006
    ..In primates, androgens can play a synergistic role with FSH in promoting the early follicular recruitment, which is critical in assisted reproduction technique programmes...
  2. pmc The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?
    Norbert Gleicher
    Center for Human Reproduction, New York, New York, USA
    Reprod Biol Endocrinol 9:116. 2011
    ..Effects of androgens on follicle maturation have been controversial for some time. Here, we review the potential of their applications in improving human ovulation induction, based on human and animal data, reported in the literature...
  3. ncbi AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis
    S L Broer
    Department of Reproductive Medicine and Gynecology, University Medical Center, GA Utrecht, The Netherlands
    Hum Reprod Update 17:46-54. 2011
    ..The aim of this study was to assess the accuracy of AMH and antral follicle count (AFC) as predictors of an excessive response in IVF/ICSI treatment...
  4. ncbi Anti-Müllerian hormone: a new marker for ovarian function
    Jenny A Visser
    Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Reproduction 131:1-9. 2006
    ..This review summarizes recent findings concerning AMH and its role as a marker for the quantitative aspect of ovarian reserve as well as ovarian dysfunction...
  5. ncbi Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve
    I A J van Rooij
    Department of Reproductive Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, Netherlands
    Hum Reprod 17:3065-71. 2002
    ..Therefore, we studied the relationship between AMH levels and ovarian response during ovarian stimulation for IVF...
  6. ncbi Serum anti-Müllerian hormone and FSH: prediction of live birth and extremes of response in stimulated cycles--implications for individualization of therapy
    Scott M Nelson
    Reproductive and Maternal Medicine, Division of Developmental Medicine, University of Glasgow, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Hum Reprod 22:2414-21. 2007
    ..Serum concentrations of anti-Müllerian hormone (AMH) correlate with oocyte yield in assisted reproduction treatment (ART) cycles, however, performance of AMH for prediction of live birth is unknown...
  7. ncbi Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males
    Waljit S Dhillo
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 90:6609-15. 2005
    ..The endogenous neuropeptide agonist for G protein-coupled receptor 54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal axis in rodents and primates...
  8. ncbi Regulation of ovarian function: the role of anti-Müllerian hormone
    Alexandra L L Durlinger
    Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Reproduction 124:601-9. 2002
    ....
  9. ncbi Follicle stimulating hormone-induced growth promotion and gene expression profiles on ovarian surface epithelial cells
    Qing Ji
    Department of Pathology, Olive View UCLA Medical Center, Sylmar, CA, USA
    Int J Cancer 112:803-14. 2004
    ..FSH-induced gene expression profiles on MCV152 cells support the standing hypothesis that FSH is a probable risk factor for ovarian cancerous development...
  10. ncbi Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization
    JoAnne S Richards
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Recent Prog Horm Res 57:195-220. 2002
    ..Whereas PR appears to regulate the induction of novel proteases, COX-2 appears to regulate cumulus expansion. This review summarizes some new aspects of peptide and steroid hormone signaling in the rodent ovary...
  11. ncbi Utility of age-specific serum anti-Müllerian hormone concentrations
    David H Barad
    Center for Human Reproduction New York and Foundation for Reproductive Medicine, New York, NY, USA
    Reprod Biomed Online 22:284-91. 2011
    ....
  12. pmc FSH isoform pattern in classic galactosemia
    Cynthia S Gubbels
    Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands
    J Inherit Metab Dis 34:387-90. 2011
    ..Our results do not support that FSH dysfunction due to a less acidic isoform pattern because of hypoglycosylation is a key mechanism of POI in this disease...
  13. ncbi Anti-Müllerian hormone-based approach to controlled ovarian stimulation for assisted conception
    Scott M Nelson
    Section of Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Hum Reprod 24:867-75. 2009
    ..ovarian stimulation (COS) for assisted conception is complicated by variable ovarian response to follicle stimulating hormone. We hypothesized that anti-Müllerian hormone (AMH), a predictor of oocyte yield, may facilitate ..
  14. ncbi Serum inhibin B and follicle-stimulating hormone levels as tools in the evaluation of infertile men: significance of adequate reference values from proven fertile men
    Anna Maria Andersson
    Department of Growth and Reproduction, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 89:2873-9. 2004
    ....
  15. ncbi Antimüllerian hormone serum levels: a putative marker for ovarian aging
    Annemarie de Vet
    Department of Obstetrics and Gynecology, Division of Reproductive Medicine, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Fertil Steril 77:357-62. 2002
    ..To investigate whether serum concentrations of antimüllerian hormone may be used as a marker for ovarian aging...
  16. ncbi Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal follicle-stimulating hormone level
    Dave J Hendriks
    Department of Reproductive Medicine, Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands
    Fertil Steril 83:291-301. 2005
    ..To assess the predictive performance of the antral follicle count (AFC) as a test for ovarian reserve in IVF patients and to compare this performance with that of basal FSH level...
  17. ncbi Dynamic assays of inhibin B, anti-Mullerian hormone and estradiol following FSH stimulation and ovarian ultrasonography as predictors of IVF outcome
    Talia Eldar-Geva
    IVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Ben Gurion University of the Negev, Jerusalem 91031, Israel
    Hum Reprod 20:3178-83. 2005
    ....
  18. ncbi Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice
    J Singh
    Department of Obstetrics and Gynecology, University of Sydney, New South Wales, Australia
    Endocrinology 136:5311-21. 1995
    ..The hpg mouse model is a useful new paradigm to study the molecular basis of the hormonal induction of spermatogenesis...
  19. ncbi Circulating basal anti-Müllerian hormone levels as predictor of ovarian response in women undergoing ovarian stimulation for in vitro fertilization
    Luciano G Nardo
    Department of Reproductive Medicine, St Mary s Hospital, Manchester, United Kingdom
    Fertil Steril 92:1586-93. 2009
    ..To evaluate the clinical value of basal anti-Müllerian hormone (AMH) measurements compared with other available determinants, apart from chronologic age, in the prediction of ovarian response to gonadotrophin stimulation...
  20. ncbi Evaluation of anti-Müllerian hormone as a test for the prediction of ovarian reserve
    Janet Kwee
    Division of Reproductive Endocrinology and Fertility and IVF Centre, Department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Fertil Steril 90:737-43. 2008
    ..To compare in an integral way the value of the basal serum anti-Müllerian hormone (AMH) level with most of the established ovarian reserve tests...
  21. ncbi Comparing anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) as predictors of ovarian function
    David H Barad
    Center for Human Reproduction, New York, New York 10021, USA
    Fertil Steril 91:1553-5. 2009
    ..In 76 IVF cycles investigated, AMH was clearly superior in predicting IVF outcomes in comparison with FSH...
  22. ncbi Age-specific levels for basal follicle-stimulating hormone assessment of ovarian function
    David H Barad
    Center for Human Reproduction, New York and the Foundation for Reproductive Medicine, Chicago, Illinois, USA
    Obstet Gynecol 109:1404-10. 2007
    ..The objective of this study was to characterize the continuum of ovarian function based on age-specific categories of baseline FSH...
  23. ncbi Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3
    Renato Fanchin
    Departments of Obstetrics and Gynecology and Reproductive Medicine, Clamart, France, and Biochemistry and Hormonology, Paris and Clamart, France
    Hum Reprod 18:323-7. 2003
    ..The study aim was to compare the relationship between serum anti-Müllerian hormone (AMH) levels and other markers of ovarian function with early antral follicle count on day 3...
  24. ncbi Follicle-stimulating hormone regulates oocyte growth by modulation of expression of oocyte and granulosa cell factors
    Fiona H Thomas
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa Regional Cancer Centre, Ottawa, Ontario, Canada K1H 1C4
    Endocrinology 146:941-9. 2005
    ..05), suggesting that lowered KL-1/KL-2 ratio is important for oocyte growth. In summary, the correct concentration of FSH is crucial for appropriate modulation of KL and BMP-15 to promote oocyte growth...
  25. ncbi Mutations and polymorphisms of the FSH receptor (FSHR) gene: clinical implications in female fecundity and molecular biology of FSHR protein and gene
    Cristina Lussiana
    Reproductive Medicine and IVF Unit, Department of Gynaecological and Obstetrical Sciences, University of Turin, S Anna Hospital, Torino, Italy
    Obstet Gynecol Surv 63:785-95. 2008
    ..In the second part, it describes the techniques to study the FSHR gene sequence, and gives more details about the molecular biology of FSHR protein, of FSHR gene and its mutations...
  26. ncbi Anti-Müllerian hormone (AMH) defines, independent of age, low versus good live-birth chances in women with severely diminished ovarian reserve
    Norbert Gleicher
    The Center for Human Reproduction and Foundation for Reproductive Medicine, New York, New York 10021, USA
    Fertil Steril 94:2824-7. 2010
    ..04 ng/mL but significantly increased at AMH 0.41-1.05 ng/mL, resulting in similarly low live-birth rates at all AMH levels ≤1.05 ng/mL and significantly improved live-birth rates at AMH ≥1.06 ng/mL...
  27. ncbi Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes
    Sandeep Dhindsa
    Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA
    J Clin Endocrinol Metab 89:5462-8. 2004
    ..001). FT correlated strongly with cFT (r = 0.919; P < 0.001) but not with SHBG. LH levels correlated positively with FT (r = 0.287; P < 0.05). We conclude that hypogonadotropic hypogonadism occurs commonly in type 2 diabetes...
  28. pmc Anti-mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory, Room 1846, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 93:3478-83. 2008
    ..The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP)...
  29. ncbi Influence of lysophosphatidic acid on estradiol production and follicle stimulating hormone action in bovine granulosa cells
    Dorota Boruszewska
    Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
    Reprod Biol 13:344-7. 2013
    ..the study was to examine the effect of lysophosphatidic acid (LPA) on 17β-estradiol (E2) synthesis and follicle stimulating hormone (FSH) action in bovine granulosa cells...
  30. pmc The ovary: basic biology and clinical implications
    JoAnne S Richards
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Clin Invest 120:963-72. 2010
    ....
  31. ncbi Pituitary transcription factor Prop-1 stimulates porcine follicle-stimulating hormone beta subunit gene expression
    Satoko Aikawa
    Laboratory of Molecular Biology and Gene Regulation, Department of Life Science, School of Agriculture, Meiji University, Kanagawa 214 8571, Japan
    Biochem Biophys Res Commun 324:946-52. 2004
    ....
  32. pmc Hormones in synergy: regulation of the pituitary gonadotropin genes
    Varykina G Thackray
    Department of Reproductive Medicine, Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA 92093 0674, USA
    Mol Cell Endocrinol 314:192-203. 2010
    ..We also discuss how recent technological advances will help identify additional factors involved in the differential hormonal regulation of LH and FSH...
  33. ncbi Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women
    Waljit S Dhillo
    Department of Metabolic Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 92:3958-66. 2007
    ..GPR54-null mice exhibit reproductive dysfunction, and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates, and human males. The effects of kisspeptin administration to human females are unknown...
  34. ncbi Serum anti-Müllerian hormone dynamics during controlled ovarian hyperstimulation
    Renato Fanchin
    Departments of Obstetrics and Gynecology and Reproductive Medicine, Biology and Genetics of Reproduction, and Biochemistry and Hormonology, Clamart, France
    Hum Reprod 18:328-32. 2003
    ..The study aim was to investigate possible changes in serum anti-Müllerian hormone (AMH) levels during controlled ovarian hyperstimulation (COH), and their possible relationship with follicular development and other ovarian hormones...
  35. ncbi The metabolic syndrome and disturbances in hormone levels in long-term survivors of disseminated testicular cancer
    Janine Nuver
    Department of Medical Oncology, University Hospital Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Oncol 23:3718-25. 2005
    ..The metabolic syndrome may be an important risk factor for cardiovascular disease in long-term survivors of testicular cancer (TC). We investigated the associations between hormone levels and the metabolic syndrome in these men...
  36. pmc Genetically determined dosage of follicle-stimulating hormone (FSH) affects male reproductive parameters
    Marina Grigorova
    Human Molecular Genetics Research Group, Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
    J Clin Endocrinol Metab 96:E1534-41. 2011
    ..We have previously identified the association between the T-allele of the FSHB promoter polymorphism (rs10835638; G/T, -211 bp from the mRNA start) and significantly reduced male serum FSH...
  37. ncbi The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome
    S K Blank
    The Center for Research in Reproduction, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hum Reprod Update 12:351-61. 2006
    ..The subsequent abnormalities in gonadotropin secretion, androgen production and ovulatory function may support progression towards the adult PCOS phenotype...
  38. ncbi Live birth chances in women with extremely low-serum anti-Mullerian hormone levels
    Andrea Weghofer
    Department of Obstetrics and Gynecology, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Hum Reprod 26:1905-9. 2011
    ..To determine whether women with extremely low-serum anti-Mullerian hormone (AMH) levels (<0.1-0.4 ng/ml) still demonstrate live birth potential with assisted reproduction and whether such potential is age dependent...
  39. ncbi The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells
    Yunli Lai
    Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People s Hospital, Shanghai, P R China
    Int J Oncol 42:776-84. 2013
    Previously, we demonstrated that follicle stimulating hormone (FSH) enhanced VEGF expression and facilitated ovarian cancer angiogenesis via the PI3K/AKT signaling pathway...
  40. ncbi Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles
    Miyun Tsai-Turton
    Center for Occupational and Environmental Health, University of California Irvine, 5201 California Avenue, Suite 100, Irvine, California 92617, USA
    Endocrinology 147:1224-36. 2006
    ..These findings provide evidence that oxidative stress induces apoptosis in preovulatory follicles and that the antiapoptotic effect of FSH is mediated in part by stimulation of follicular GSH synthesis and suppression of ROS production...
  41. ncbi A systematic review of tests predicting ovarian reserve and IVF outcome
    F J Broekmans
    Department of Reproductive Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands
    Hum Reprod Update 12:685-718. 2006
    ..As poor ovarian response will provide some information on OR status, especially if the stimulation is maximal, entering the first cycle of IVF without any prior testing seems to be the preferable strategy...
  42. pmc Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility
    Xiaoping Ma
    Departments of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:17294-9. 2004
    ..Thus, LHbeta null mice represent a model to study the consequences of an isolated deficiency of LH ligand in reproduction, while retaining normal LH-responsiveness in target cells...
  43. ncbi Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis
    Channa N Jayasena
    Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 94:4315-23. 2009
    ..However, the effects of kisspeptin on gonadotropin release in women with hypothalamic amenorrhea (HA) and the effects of repeated administration of kisspeptin to humans are unknown...
  44. ncbi The testicular receptor for follicle stimulating hormone: structure and functional expression of cloned cDNA
    R Sprengel
    University Heidelberg, Zentrum fur Molekulare Biologie, Federal Republic of Germany
    Mol Endocrinol 4:525-30. 1990
    ..The selectivity for FSH is attested by the fact that the related human glycoprotein hormones human CG and human TSH do not stimulate adenylyl cyclase in FSH-R expressing cells even when these hormones are present at high concentrations...
  45. ncbi Follicle-stimulating hormone regulation of microRNA expression on progesterone production in cultured rat granulosa cells
    Nan Yao
    Graduate School of Peking Union Medical College, Beijing, China
    Endocrine 38:158-66. 2010
    ..Taken together, our results pointed to a novel mechanism for the pleiotropic effects of FSH...
  46. ncbi 3',5'-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation
    Gang Ning
    State Key Laboratories for AgroBiotechnology and Department of Animal Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, PR China
    Mol Endocrinol 22:1682-94. 2008
    ..Our study also implicates that CYP51 activity in cumulus cells participates in EGF receptor signaling-regulated oocyte meiotic resumption...
  47. ncbi Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes
    Xiufen Chen
    State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100094, People s Republic of China
    J Endocrinol 197:409-19. 2008
    ..These data together suggested that EGFR activation, by PKC signal pathway, participates in FSH-induced porcine oocyte meiotic resumption...
  48. ncbi Anti-Müllerian hormone levels in the spontaneous menstrual cycle do not show substantial fluctuation
    Wouter J K Hehenkamp
    Department of Gynaecology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Clin Endocrinol Metab 91:4057-63. 2006
    ..Anti-Müllerian hormone (AMH), a quantitative marker for ovarian reserve, has been suggested to be independent of the classical endocrine fluctuations of the menstrual cycle...
  49. ncbi Primary ovarian dysfunction contributes to the hypogonadism in women with Prader-Willi Syndrome
    Talia Eldar-Geva
    Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Horm Res 72:153-9. 2009
    ..To investigate the etiology of hypogonadism in women with Prader-Willi Syndrome (PWS)...
  50. ncbi Models of glycoprotein hormone receptor interaction
    William R Moyle
    Department of OBGYN, Robert Wood Johnson Rutgers Medical School, Piscataway, NJ 08854, USA
    Endocrine 26:189-205. 2005
    ..The unique manner in which these ligands appear to interact with their receptors may have facilitated hormone and receptor co-evolution during early vertebrate speciation...
  51. pmc Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely
    Sungeun Lee
    Division of Reproductive Sciences, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    Endocrinology 150:3855-62. 2009
    ..Taken together, this study demonstrates that theca Esr1 plays a critical role in regulating female reproduction...
  52. ncbi Enhanced response of granulosa and theca cells from sheep carriers of the FecB mutation in vitro to gonadotropins and bone morphogenic protein-2, -4, and -6
    B K Campbell
    Department of Obstetrics and Gynaecology, Queen s Medical Centre, University of Nottingham, UK
    Endocrinology 147:1608-20. 2006
    ....
  53. pmc Serum kisspeptin levels in Korean girls with central precocious puberty
    Young Jun Rhie
    Department of Pediatrics, Korea University College of Medicine, Seoul, Korea
    J Korean Med Sci 26:927-31. 2011
    ..Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed...
  54. pmc Pregnancy and delivery after stimulation with rFSH of a galatosemia patient suffering hypergonadotropic hypogonadism: case report
    Yves J R Menezo
    IRH Laboratoire Marcel Merieux, Bron, France
    J Assist Reprod Genet 21:89-90. 2004
    ..A 26-year-old woman, suffering GALT (Galactoso-1-phosphate uridyltransferase) had a premature ovarian failure with amenorrhea since the age of 19. The circulating level for FSH was 83 and 34 mU/mL for LH...
  55. pmc Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
    A Dierich
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, 163, 67404 Illkirch, Strasbourg, France
    Proc Natl Acad Sci U S A 95:13612-7. 1998
    ..The phenotype of FSH-R -/- mice is reminiscent of human hypergonadotropic ovarian dysgenesis and infertility...
  56. ncbi hMG increases the yield of mature oocytes and excellent-quality embryos in patients with a previous cycle having a high incidence of oocyte immaturity
    Heather G Huddleston
    Center for Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA
    Fertil Steril 92:946-9. 2009
    ..In a selected group of patients with >20% oocyte immaturity during an IVF cycle with FSH alone, the addition of hMG to the stimulation protocol results in a higher yield of mature oocytes and excellent-quality embryos...
  57. ncbi Association between tobacco exposure and reproductive parameters in adolescent males
    Jonas Richthoff
    Centre of Reproductive Medicine, Scanian Andrology Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Int J Androl 31:31-9. 2008
    ..Smoking seems to impair sperm production and epididymal as well as accessory sex gland function and could be one of the factors contributing to regional differences in sperm parameters...
  58. ncbi The cohort of antral follicles measuring 2-6 mm reflects the quantitative status of ovarian reserve as assessed by serum levels of anti-Müllerian hormone and response to controlled ovarian stimulation
    Kannamannadiar Jayaprakasan
    Nottingham University Research and Treatment Unit in Reproduction, Division of Human Development, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom
    Fertil Steril 94:1775-81. 2010
    ....
  59. pmc Biomarkers of ovarian function in girls and women with classic galactosemia
    Rebecca D Sanders
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Fertil Steril 92:344-51. 2009
    ..To determine whether premature ovarian insufficiency (POI) associated with classic galactosemia results from a true impairment of ovarian function or from aberrant FSH...
  60. pmc Discordances between follicle stimulating hormone (FSH) and anti-Müllerian hormone (AMH) in female infertility
    Norbert Gleicher
    The Center for Human Reproduction CHR, New York and Foundation for Reproductive Medicine, New York, NY, USA
    Reprod Biol Endocrinol 8:64. 2010
    b>Follicle stimulating hormone (FSH) and anti-Müllerian hormone (AMH) represent the two most frequently utilized laboratory tests in determining ovarian reserve (OR)...
  61. pmc Use of letrozole in assisted reproduction: a systematic review and meta-analysis
    Antonio Requena
    IVI Madrid, Santiago de Compostela 88, E 28035 Madrid, Spain
    Hum Reprod Update 14:571-82. 2008
    ..AIs induce ovulation by inhibiting estrogen production; the consequent hypoestrogenic state increases GnRH release and pituitary follicle-stimulating hormone (FSH) synthesis...
  62. ncbi Anti-müllerian hormone is a promising predictor for the occurrence of the menopausal transition
    Ilse A J van Rooij
    Department of Reproductive Medicine, University Medical Center, 3584 CX, The Netherlands
    Menopause 11:601-6. 2004
    ..In this study we explored several markers for their ability to predict the occurrence of the transition to menopause...
  63. ncbi Putative predictors of antibodies against follicle-stimulating hormone in female infertility: a study based on in vitro fertilization patients
    Kadri Haller
    Department of Immunology, Institute of General and Molecular Pathology, Centre of Molecular and Clinical Medicine, University of Tartu, Biomedicum, Ravila Str 19, Tartu 50411, Estonia
    Am J Reprod Immunol 57:193-200. 2007
    ..Here, we investigated the parameters associated with anti-FSH antibodies in in vitro fertilization (IVF) patients...
  64. ncbi Effects of gonadotrophins, growth hormone, and activin A on enzymatically isolated follicle growth, oocyte chromatin organization, and steroid secretion
    Safiriyu Idowu Ola
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Mol Reprod Dev 75:89-96. 2008
    ..Follicle survival was highest in follicle stimulating hormone (FSH)-AA group in both cultured preantral (91.8%) and antral follicles (82.7%)...
  65. ncbi Influence of ovarian stimulation with HP-hMG or recombinant FSH on embryo quality parameters in patients undergoing IVF
    Søren Ziebe
    Fertility Clinic, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 22:2404-13. 2007
    ..There are limited data on the impact of different gonadotrophin preparations on embryo quality...
  66. pmc FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A
    Mary Hunzicker-Dunn
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell Signal 18:1351-9. 2006
    ..Rather, cross-talk between and among signaling cascades is required. We will review the signaling cascades activated by FSH in granulosa cells and how these cascades contribute to the regulation of select target gene expression...
  67. pmc Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from Smad
    Youngkyu Park
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 280:9135-48. 2005
    ..These results suggest that proliferation and differentiation of GCs in response to FSH plus activin requires both removal of FOXO1-dependent repression and positive signaling from Smad2/3...
  68. ncbi Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation
    Norbert Gleicher
    Center for Human Reproduction, New York and Foundation for Reproductive Medicine, New York, NY, USA
    Reprod Biomed Online 21:360-5. 2010
    ..001). DHEA supplementation, thus, significantly improved ovarian reserve in parallel with longer DHEA use and was more pronounced in younger women...
  69. ncbi Activin-binding protein from rat ovary is follistatin
    T Nakamura
    Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    Science 247:836-8. 1990
    ..A binding protein for activin was purified from rat ovary and was identical to follistatin, a specific inhibitor of FSH release. It is likely that the binding protein participates in the diverse regulatory actions of activin...
  70. ncbi Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
    T R Kumar
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 15:201-4. 1997
    b>Follicle stimulating hormone (FSH) is a member of the glycoprotein hormone family that includes luteinzing hormone (LH), thyroid stimulating hormone, and chorionic gonadotropin...
  71. pmc Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence
    Jie Qiao
    Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, People s Republic of China
    Hum Reprod Update 17:17-33. 2011
    ..Although patients with PCOS are typically characterized by increased numbers of oocytes retrieved during IVF, they are often of poor quality, leading to lower fertilization, cleavage and implantation rates, and a higher miscarriage rate...
  72. ncbi The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest
    Sophie Jonard
    Department of Endocrine Gynaecology and Reproductive Medicine, Hopital Jeanne de Flandre, avenue Eugene Avinee, CHRU, 59037 Lille, France
    Hum Reprod Update 10:107-17. 2004
    ..The loss of cyclic rhythm would prevent the inter-cycle elevation of FSH, thus perpetuating the impairment of the ovulation process...
  73. pmc Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men
    J T George
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    J Clin Endocrinol Metab 96:E1228-36. 2011
    ..Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been studied in man...
  74. ncbi Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome
    Antonio La Marca
    Department of Obstetrics and Gynecology, University of Siena, Siena, Italy
    Fertil Steril 78:1234-9. 2002
    ..To investigate the effects of reduction of insulin resistance and hyperinsulinemia associated with the polycystic ovary syndrome (PCOS) on FSH-stimulated ovarian aromatase activity...
  75. ncbi Anti-Müllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age
    Joop S E Laven
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:318-23. 2004
    ..A less pronounced AMH decrease over time in these women may suggest retarded ovarian aging. The latter hypothesis, however, should be confirmed by longitudinal studies...
  76. ncbi Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series
    P R Casson
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Baylor College of Medicine, 6550 Fannin, Suite 801, Houston, Texas 77030, USA
    Hum Reprod 15:2129-32. 2000
    ..In this small series, DHEA improved response to ovarian stimulation even after controlling for gonadotrophin dose. Supplemental DHEA treatment during ovarian stimulation may represent a novel way to maximize ovarian response...
  77. ncbi Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status
    John F Randolph
    Clinical Centers University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 88:1516-22. 2003
    ..All hormone concentrations were significantly correlated with body mass index. We conclude that serum sex steroid, FSH, and SHBG levels vary by ethnicity, but are highly confounded by ethnic disparities in body size...
  78. ncbi Estrogen receptor-beta is critical to granulosa cell differentiation and the ovulatory response to gonadotropins
    John F Couse
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 146:3247-62. 2005
    ..e. antrum and cumulus oocyte complex), enzymatic activity (i.e. capacity to convert androgen precursor to estradiol), and receptor signaling pathways (i.e. LH receptor) to respond to a gonadotropin surge and expel a healthy oocyte...
  79. ncbi Anti-Müllerian hormone plasma levels in spontaneous menstrual cycle and during treatment with FSH to induce ovulation
    Antonio La Marca
    Department of Obstetrics Gynaecology and Paediatric Sciences, Institute of Obstetrics and Gynaecology, University of Modena and Reggio Emilia, Policlinico of Modena, Largo del Pozzo, 41100 Modena, Italy
    Hum Reprod 19:2738-41. 2004
    ..The present study was undertaken to assess the effect of controlled ovarian stimulation on AMH secretion by the ovary in healthy women in order to obtain more insight into the relationship between this peptide and gonadal steroids...
  80. ncbi Gonadal function in male and female patients with classic galactosemia
    M E Rubio-Gozalbo
    Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands
    Hum Reprod Update 16:177-88. 2010
    ..The underlying mechanism is not understood and several pathogenic mechanisms have been proposed. Timing of the lesion, prenatal or chronic post-natal, or a combination of both are not yet clear...
  81. ncbi Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: The Study of Women's Health across the Nation (SWAN) Daily Hormone Study
    Nanette Santoro
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Endocrinol Metab 89:2622-31. 2004
    ..Comparisons to younger women indirectly support the inhibin hypothesis, which proposes that the initiating event in the menopausal transition is the loss of inhibin negative feedback on FSH secondary to a diminished follicular reserve...
  82. ncbi Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients
    Eman A Elgindy
    Department of Obstetrics and Gynecology, Faculty of Medicine, the University of Zagazig, Zagazig, Egypt
    Fertil Steril 89:1670-6. 2008
    ..To measure serum anti-Müllerian hormone (AMH) during different phases of the menstrual cycle and to correlate the measurements with ovarian response and clinical-pregnancy rates in intracytoplasmic sperm injection cycles...
  83. ncbi Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty
    Signe Sloth Mogensen
    Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 96:1393-401. 2011
    ..The aim of this study was to describe a large cohort of Caucasian girls referred with signs of early puberty according to etiology and compare biochemical characteristics...
  84. ncbi Production of inhibin A not B in rams: changes in plasma inhibin A during testis growth, and expression of inhibin/activin subunit mRNA and protein in adult testis
    A S McNeilly
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Reproduction 123:827-35. 2002
    ....
  85. ncbi A new era in ovulation induction
    Hananel Holzer
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Fertil Steril 85:277-84. 2006
    ..To evaluate the efficacy of aromatase inhibitors in ovulation induction, superovulation, and IVF...
  86. ncbi Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve
    Laszlo F J M M Bancsi
    Department of Reproductive Medicine, Division of Obstetrics, Neonatology and Gynecology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Fertil Steril 77:328-36. 2002
    ..To identify and quantify predictors of poor ovarian response in in vitro fertilization (IVF). DESIGN; Prospective study. SETTING; Tertiary fertility center...
  87. pmc Influence of menopause on high density lipoprotein-cholesterol and lipids
    C J Kim
    Department of Internal Medicine, Chung Ang University Medical Center, Seoul, Korea
    J Korean Med Sci 15:380-6. 2000
    ..Perimenopausal status, although transient, may favor Lp(a) and lipid profiles for delaying atherosclerosis...
  88. ncbi Effects of culture medium, serum type, and various concentrations of follicle-stimulating hormone on porcine preantral follicular development and antrum formation in vitro
    Jiude Mao
    Department of Animal Sciences, University of Missouri Columbia, 65211, USA
    Biol Reprod 67:1197-203. 2002
    ..These results suggest that a longer term culture of preantral follicles (>4 days) may be needed to produce oocytes capable of undergoing meiosis in vitro...
  89. ncbi Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial
    Francisco Fábregues
    Institut Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Faculty of Medicine University of Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Hum Reprod 24:349-59. 2009
    ..Studies in macaques have indicated that androgens have some synergistic effects with FSH on folliculogenesis. This study investigated the usefulness of pretreatment with transdermal testosterone in low-responder IVF patients...
  90. ncbi Serum anti-mullerian hormone levels reflect the size of the primordial follicle pool in mice
    Marlies E Kevenaar
    Department of Internal Medicine, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Endocrinology 147:3228-34. 2006
    ..Therefore, AMH is an excellent marker to assess the quantitative aspect of ovarian reserve, which may be useful for women at risk for early ovarian aging such as survivors of childhood cancers...
  91. pmc Regulation of mouse follicle development by follicle-stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose
    Pamela K Kreeger
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 73:942-50. 2005
    ..The culture system can be adapted to each stage of development, which will be especially critical for translation to human follicles that have a longer developmental period...
  92. ncbi Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat
    V M Navarro
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Endocrinology 146:1689-97. 2005
    ..Overall, it is proposed that the KiSS-1/GPR54 system is a novel, pivotal downstream element in the neuroendocrine network governing gonadotropin secretion...
  93. ncbi Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls
    A M Andersson
    Department of Growth and Reproduction, Copenhagen University Hospital, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen OE, Denmark
    J Clin Endocrinol Metab 89:3161-7. 2004
    ..On the other hand, the parallel impairment of spermatogenesis and Leydig cells may reflect a congenital dysfunction of both compartments caused by a testicular dysgenesis during fetal/infant development...
  94. ncbi Establishment of detailed reference values for luteinizing hormone, follicle stimulating hormone, estradiol, and progesterone during different phases of the menstrual cycle on the Abbott ARCHITECT analyzer
    Reto Stricker
    DIANALAB SA, Geneva, Switzerland
    Clin Chem Lab Med 44:883-7. 2006
    ..Based on our data, we were able to establish detailed reference values for LH, FSH, estradiol, and progesterone, which should aid in the interpretation of results for these reproductive hormones in a variety of circumstances...
  95. ncbi Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK)
    Lucie Tosca
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Biol Reprod 76:368-78. 2007
    ..Thus, in bovine granulosa cells, metformin decreases steroidogenesis and MAPK3/MAPK1 phosphorylation through AMPK activation...
  96. ncbi Anti-Müllerian hormone attenuates the effects of FSH on follicle development in the mouse ovary
    A L Durlinger
    Department of Endocrinology and Reproduction, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Rotterdam, The Netherlands 3000
    Endocrinology 142:4891-9. 2001
    ....
  97. ncbi Relevance of anti-Mullerian hormone measurement in a routine IVF program
    C Gnoth
    Center for Family Planning, Gynecological Endocrinology and Reproductive Medicine, Rheydter Strasse 143, 41515 Grevenbroich, Germany
    Hum Reprod 23:1359-65. 2008
    ..This prospective study was conducted to evaluate the relevance of AMH in a routine IVF program...
  98. ncbi Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol
    André Hazout
    ART Unit Eylau la Muette, Clinic La Muette, Paris, France
    Fertil Steril 82:1323-9. 2004
    ..To test the hypothesis that the concentration of early follicular phase serum antimullerian hormone (AMH) or mullerian-inhibiting substance (MIS) is a useful marker of ovarian response and assisted reproductive technology (ART) outcome...
  99. ncbi Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion
    Iain J Clarke
    Department Physiology, Building 13F, Monash University, Clayton Victoria 3800, Australia
    Endocrinology 149:5811-21. 2008
    ..These data indicate that RFRP-3 is a specific and potent mammalian gonadotropin-inhibiting hormone, and that it acts upon pituitary gonadotropes to reduce GnRH-stimulated gonadotropin secretion...
  100. ncbi Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels
    A M Andersson
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 82:3976-81. 1997
    ....
  101. ncbi A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report
    S K Goswami
    Institute of Reproductive Medicine, Salt Lake, Kolkata 700091, India
    Hum Reprod 19:2031-5. 2004
    ..Use of letrozole, a selective inhibitor of aromatase, reduces the gonadotrophin dose required to induce follicular maturation. We evaluated whether incorporation of letrozole could be an effective low-cost IVF protocol for poor responders...

Research Grants64

  1. Transcriptional control of FSH expression
    Daniel Bernard; Fiscal Year: 2007
    ..Given the critical importance of FSH for fertility in women, these results may aid in the design of novel contraceptives or may pinpoint causes of infertility that have thus far eluded our detection. ..
  2. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..randomization, we propose to examine ESH (testosterone, estradiol, sex hormone binding globulin) and follicle stimulating hormone (FSH) in a subset of DPP women without exogenous hormone use (n=865) and DPP women with exogenous ..
  3. Transcriptional control of pituitary gonadotropin genes
    Varykina G Thackray; Fiscal Year: 2013
    ..Funding of this proposal will also allow the PI, as an Early-Stage Investigator, to establish a fully-independent research program in the field of reproductive endocrinology. ..
  4. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..Successful completion of these studies would enable the development of prognostic and diagnostic tests for AD, and provide insights into the neuroendocrine mechanisms of AD. ..
  5. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ....
  6. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..We also propose to extend the STRAW recommendations to be more broadly applicable to the range of women's diverse experience of reproductive aging. ..
  7. Oocyte-derived R-spondin2 as a Follicle Stimulating Hormone
    AARON JW HSUEH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Oocyte-derived R-spondin2 as a Follicle Stimulating Hormone Abstract: The Wingless (Wnt) signaling pathway is essential for cell proliferation from flies to mammals...
  8. The Effects of Estradiol on Genetic Risk for Disordered Eating During Puberty
    Kelly L Klump; Fiscal Year: 2013
    ..e., progesterone, luteinizing hormone, follicle stimulating hormone, physical changes of puberty, body weight and adiposity) that change during puberty...
  9. Development of Superactive Analogs of FSH for Human Infertility
    BRUCE DALE WEINTRAUB; Fiscal Year: 2013
    ..We have licensed TR4401 to the worldwide leading veterinary superovulation company, Bioniche, Inc. for veterinary use, with a possible option to also co-develop the analog for human use. ..
  10. Melatonin in Menopausal Depression
    Barbara L Parry; Fiscal Year: 2012
    ..menopausal DP have increased melatonin duration, extended sleep time, recent hypogonadism, higher Follicle Stimulating Hormone (FSH) levels and Body Mass Index (BMI) that correlate with depression ratings...
  11. The interaction between sleep and reproductive hormone secretion during puberty
    NATALIE DARA SHAW; Fiscal Year: 2013
    ..GnRH) pulse generator reawakens, stimulating pituitary secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) and consequent gonadal sex steroid secretion...
  12. Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOS
    Christopher R McCartney; Fiscal Year: 2012
    ..abstract_text> ..
  13. Gonadotropins in a female model of age-induced hypertension
    KATHRYN L SANDBERG; Fiscal Year: 2012
    ..applicant): This project addresses the PA-10-015 by proposing to investigate the role and mechanisms of follicle stimulating hormone (FSH) and leutinizing hormone (LH) in the age-induced increase in blood pressure (BP) and body weight (..
  14. Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System
    Teresa K Woodruff; Fiscal Year: 2013
    ....
  15. Study of Women's Health Across the Nation V: Endocrinology/CLASS Laboratory
    Daniel S McConnell; Fiscal Year: 2013
    ..risk factors, metabolic syndrome, body composition, insulin and glucose levels, and sexual function;3) follicle stimulating hormone to be strongly associated with bone loss, vasomotor symptoms and timing of the final menstrual period;4)..
  16. Functional Significance of the HIF1 Transcriptome in Granulosa Cells
    John H Nilson; Fiscal Year: 2013
    ..Follicles are restrained at the preantral stage until they are stimulated by the pituitary hormone follicle stimulating hormone (FSH)...
  17. GnRH-Regulated Transcriptome in the Gonadotrope
    Djurdjica Coss; Fiscal Year: 2010
    ..Thus, understanding the molecular mechanisms governing gonadotrope gene expression will lead to insight into the physiology and pathophysiology of the reproductive system. ..
  18. A Novel Function of the Oocyte in Estrogen-Regulated FSH Action
    Shunichi Shimasaki; Fiscal Year: 2009
    ..The proposed studies aim to elucidate the molecular and cellular mechanisms of this finding, which may lead to develop pharmaceutical regimens for treating ovarian dysfunctions, particularly in aging women. ..
  19. FSH-STIMULATED SIGNALS THAT REGULATE FOLLICULAR MATURATION
    John H Nilson; Fiscal Year: 2013
    ..Follicles are restrained at the preantral stage until they are stimulated by the pituitary hormone follicle stimulating hormone (FSH)...
  20. The Aging Pituitary-Gonadal Axis
    George R Bousfield; Fiscal Year: 2013
    ..While currently available preparations work well in young women, they become increasingly ineffective in older women, requiring higher doses and prolonged administration yet producing fewer oocytes. ..
  21. INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION
    John C Marshall; Fiscal Year: 2010
    ..Mammalian reproduction is controlled by luteinizing hormone (LH) and follicle stimulating hormone (FSH), which consist of a common alpha (a) subunit and unique beta (b) subunits that provide biological ..
  22. Identification of target genes for Lhx3 in gonadotropes
    Richard A Maurer; Fiscal Year: 2012
    ..to drastically decrease production and secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH)...
  23. FMR1 CGG Repeats in Primary Ovarian Insufficiency Women vs. 2 Comparison Groups
    Lisa M Pastore; Fiscal Year: 2013
    ..Ovarian Insufficiency (POI) is a spectrum of disorders of early ovarian aging characterized by elevated follicle stimulating hormone (FSH) levels ranging from Diminished Ovarian Reserve (DOR, FSH >10 mIU/mL and regular menses) to ..
  24. Influence of Endocrine Disruptors on Reproductive Neuroendocrine Function
    JOSEPH RAYMOND KURIAN; Fiscal Year: 2013
    ..neurons release GnRH in nearly metronomic pulses to control pituitary luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretions...
  25. Molecular Mechanisms of Gonadotrope Differentiation
    Pamela L Mellon; Fiscal Year: 2010
    ....
  26. Chemoprevention of pituitary gonadotrope tumors
    T Rajendra Kumar; Fiscal Year: 2013
    ..e., luteinizing hormone (LH) and follicle stimulating hormone (FSH)] and thus are called null cell adenomas...
  27. Role of Dicer in Gonadotrope and Reproductive Function
    T Rajendra Kumar; Fiscal Year: 2013
    ..Gonadotropes synthesize and secrete heterodimeric glycoproteins luteinizing hormone (LH) and follicle stimulating hormone (FSH) that are critical for reproductive function...
  28. Sex Differences in Vascular Markers of Stroke Risk
    Cheryl D Bushnell; Fiscal Year: 2012
    ..Estradiol, testosterone, sex hormone binding globulin, and follicle stimulating hormone (for menopausal status determination) will also be measured...
  29. Modulation of PAH ovarian toxicity by biotransformation enzyme polymorphisms
    Ulrike Luderer; Fiscal Year: 2010
    ..Specific Aim 3: To pilot test serum anti-M|llerian hormone, follicle stimulating hormone, and inhibin B concentrations as markers of ovarian reserve for study of the associations between PAH ..
  30. Biomarkers of Infertility
    ANNE ZWEIFEL STEINER; Fiscal Year: 2013
    ..who desire to conceive, and obtain baseline measures of ovarian aging: early follicular phase serum follicle stimulating hormone (FSH) and anti-m|llerian hormone (AMH)...
  31. Role of FSH in Osreoclast Formation and Function
    Mone Zaidi; Fiscal Year: 2012
    ..health problem, has for decades been attributed solely to declining estrogen levels, and although follicle stimulating hormone (FSH) levels rise sharply in parallel, a direct effect of FSH on the skeleton has never been explored...
  32. Time to Conceive
    ANNE ZWEIFEL STEINER; Fiscal Year: 2010
    ..who desire to conceive, and obtain baseline measures of ovarian aging: early follicular phase serum follicle stimulating hormone, inhibin B, and anti-mullerian hormone...
  33. Progesterone control of diurnal GnRH pulses in puberty: impact of androgen excess
    Ruchi Bhabhra; Fiscal Year: 2013
    ..normal gonadotropin secretion across puberty since rapid and slow GnRH pulse frequencies favor LH and follicle stimulating hormone (FSH) synthesis and secretion respectively...
  34. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    Ursula B Kaiser; Fiscal Year: 2013
    ..Identification of these regulatory pathways will provide insight relevant to the treatment of clinical conditions including polycystic ovarian syndrome (PCOS), hypothalamic amenorrhea, disorders of pubertal maturation, and infertility. ..
  35. The Role of AP-1 in the Gonadotrope
    Djurdjica Coss; Fiscal Year: 2013
    ..abstract_text> ..
  36. FSH as a biomarker of bone strength in younger postmenopausal women
    Margaret L Gourlay; Fiscal Year: 2010
    ..The long-term objective of the proposed study is to learn whether serum follicle stimulating hormone (FSH) could be used clinically as a biomarker to identify younger postmenopausal women with significant ..
  37. Genetics of Human Ovarian Failure
    Aleksandar Rajkovic; Fiscal Year: 2009
    ..Mutations in few genes preferentially expressed in the ovary, such as follicle stimulating hormone receptor (FSHR) and bone morphogenetic protein 15 (BMP15), have been functionally shown to afflict some ..
  38. Prenatal Organochlorine Exposure and Male Reproduction
    PAM R FACTOR LITVAK; Fiscal Year: 2010
    ..Serum will be assayed for testosterone, estradiol, follicle stimulating hormone, luteinizing hormone and inhibin B...
  39. Dissecting hormonal &neural control of social behavior in a transgenic cichlid
    SCOTT ALAN JUNTTI; Fiscal Year: 2013
    ..project to the pituitary, where they control the release of the gonadotropins luteinizing hormone and follicle stimulating hormone into the bloodstream...
  40. GNRH SIGNALING MECHANISMS IN THE PITUITARY GONADOTROPE
    MARK ANDREW LAWSON; Fiscal Year: 2013
    ..We are investigating the mechanisms cells use to adapt to stress and preserve normal cell function. These regulatory pathways are essential to assure proper reproductive hormone synthesis and reproductive success. ..
  41. PHYSIOLOGY OF BONE METABOLISM IN AN AGING POPULATION
    Sundeep Khosla; Fiscal Year: 2013
    ..Collectively, these studies strive to provide a comprehensive assesment of the pathogenesis and clinical impact of one of the most important disorders facing our aging population. ..
  42. Cyclic AMP Signaling in Granulosa Cells
    Anthony J Zeleznik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although progress has been made in understanding the role of follicle stimulating hormone (FSH) in governing the process of preovulatory folliculogenesis, a major question that remains unanswered is ..
  43. Predictors of ovarian failure after chemotherapy in young breast cancer patients
    HUI CHUN IRENE SU; Fiscal Year: 2013
    ..with lower pre-chemotherapy anti-Mullerian hormone and inhibin B levels and higher pre-chemotherapy Follicle Stimulating Hormone levels will be more likely to develop ovarian failure after adjuvant chemotherapy;2)...
  44. EXPRESSION OF AN FSH ANALOG WITH A REROUTED SECRETION PATTERN IN TRANSGENIC MICE
    IRVING NMN BOIME; Fiscal Year: 2010
    ..In addition, pathologies in which there is hyper- or hypogonadism can likely be attributed to aberrant secretion of FSH and/or LH from the pituitary. ..
  45. Kisspeptin Physiology in the Human
    Stephanie Beth Seminara; Fiscal Year: 2013
    ..hormone (GnRH) from the hypothalamus and its stimulation of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary...
  46. Neurobiology of the Menopausal Transition
    Yolanda R Smith; Fiscal Year: 2010
    ..A better understanding of the areas and sequence of brain processing changes will allow the health community to plan interventions which most effectively preserve cognitive and emotional health for women. ..
  47. EXPRESSION OF OVARIAN INHIBIN AND ACTIVIN GENES
    Kelly Mayo; Fiscal Year: 1993
    ....
  48. PRETRANSLATIONAL REGULATION OF FSH AND LH
    Margaret Wierman; Fiscal Year: 1993
    b>Follicle stimulating hormone (FSH) and luteinizing hormone (LH) are glycoprotein hormones, each comprised of two dissimilar subunits alpha and beta, encoded for the separate genes on different chromosomes...
  49. SPERMATOGENESIS: SERTOLI-GERM CELL INTERACTION
    ANNA STEINBERGER; Fiscal Year: 1991
    ..The Sc are primary targets for follicle stimulating hormone (FSH) and testosterone (T) the main regulators of spermatogenesis -- and are believed to mediate the ..
  50. NEUROTENSIN SYNTHESIS IN ARCUATE NEUROSECRETORY CELLS
    Mark Alexander; Fiscal Year: 1999
    ..By clarifying the role of NT in normal neuroendocrine function, these studies will provide a basis for future investigation of NT involvement in human neuroendocrine disorders. ..
  51. Paracrine dysregulation of oocyte competence in PCOS
    DANIEL DUMESIC; Fiscal Year: 2006
    ..PA female monkeys undergoing follicle stimulating hormone (FSH) therapy for IVF exhibit LH hypersecretion, circulating insulin excess, an exaggerated shift in ..
  52. Human Ovarian Steroidogenesis-inducing Protein
    SHAFIQ KHAN; Fiscal Year: 2004
    ..abstract_text> ..
  53. Regulation of Immediate Early Genes by GnRH in the Gonadotrope
    Djurdjica Coss; Fiscal Year: 2009
    ..Thus, understanding the molecular mechanisms governing gonadotrope gene expression will lead to insight into the physiology and pathophysiology of the reproductive system. ..
  54. STRUCTURE AND FUNCTION OF THE LH AND FSH RECEPTORS
    Deborah Segaloff; Fiscal Year: 2002
    ..Long term goals of research in this area include the ability to better understand, diagnose, and correct reproductive disorders. ..
  55. Reversal of Infertility in Ovarian Failure
    Ayman Al Hendy; Fiscal Year: 2006
    ..These women typically present with primary amenorrhea, high serum level of follicle stimulating hormone (FSH), and follicles in the ovary as judged by transvaginal ultrasound or ovarian histology...
  56. ACTIVIN, INHIBIN AND FOLLISTATIN AND OSTEOBLASTOGENESIS
    Dana Gaddy; Fiscal Year: 2003
    ..regulatory loop in the anterior pituitary to exert endocrine, paracrine, and autocrine regulation of follicle stimulating hormone (FSH) production, the contribution of these molecules to bone remodeling has not been previously ..
  57. REGULATION OF FOLLITROPIN ACTIONS
    Mario Ascoli; Fiscal Year: 2009
    ..4) Determine which of the pathways identified in Aim 1 are responsible for the differential effects of the FSH/FSHR and LH/LHR pairs on the induction of markers of granulosa cell differentiation. ..
  58. PITUITARY CELL CULTURE: ESTROGEN CONTROL OF FSH
    William Miller; Fiscal Year: 1990
    b>Follicle stimulating hormone (FSH), the primary trophic hormone for egg and sperm development in mammals, is composed of two protein subunits, alpha and beta...
  59. REPRODUCTIVE BIOLOGY OF GONADOTROPIN REGULATION
    URSULA KAISER; Fiscal Year: 2000
    ....
  60. INTERACTIONS AND ACTIVATION OF THE FSH RECEPTOR
    TAE JI; Fiscal Year: 2003
    The follicle stimulating hormone receptor (FSHR) and FSH play crucial roles in reproduction of mammal...
  61. HORMONE STORAGE AND SECRETION BY GONADOTROPES
    Gwen Childs; Fiscal Year: 1993
    ..continue the studies of subsets of pituitary gonadotropes that secrete luteinizing hormone (LH) and follicle stimulating hormone (FSH)...
  62. TRANSCRIPTIONAL REGULATION OF LH BETA GENE EXPRESSION
    Lisa Halvorson; Fiscal Year: 2003
    ..abstract_text> ..
  63. GLYCOPROTEIN HORMONE ALPHA SUBUNIT & GENE TRANSCRIPTION
    PAMELA MELLON; Fiscal Year: 1992
    ..gonadotropin (CG) is responsible for the maintenance of pregnancy and luteinizing hormone (LH) and follicle stimulating hormone (FSH) regulate gonadal function...
  64. 60-HZ MAGNETIC FIELDS AND HORMONE LEVELS IN WOMEN
    Scott Davis; Fiscal Year: 2000
    ..urinary melatonin levels and an increase in nocturnal urinary levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), and estradiol in a sample of healthy women of reproductive years...