chorionic gonadotropin

Summary

Summary: A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).

Top Publications

  1. ncbi Characterization of human chorionic gonadotropin as a novel angiogenic factor
    Marek Zygmunt
    Department of Obstetrics and Gynecology, Justus Liebig University, Klinikstrasse 32, D 35385 Giessen, Germany
    J Clin Endocrinol Metab 87:5290-6. 2002
  2. ncbi Human chorionic gonadotropin (hCG) may be a marker of systemic oxidative stress in normotensive and preeclamptic term pregnancies
    Abdelaziz Kharfi
    Département d obstétrique gynécologie, Centre Hospitalier Universitaire de Sherbrooke 3001, 12 e Avenue Nord, Sherbrooke, Quebec, Canada
    Clin Biochem 38:717-21. 2005
  3. ncbi 2nd-trimester maternal serum human chorionic gonadotropin and alpha-fetoprotein levels in male and female fetuses with Down syndrome
    Ofer Lehavi
    Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Israel
    Fetal Diagn Ther 20:235-8. 2005
  4. doi Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression
    I Van Vaerenbergh
    Vrije Universiteit Brussel and UZ Brussel, Department of Pathology, Jette, Belgium
    Reprod Biomed Online 22:263-71. 2011
  5. ncbi EGF-like growth factors as mediators of LH action in the ovulatory follicle
    Jy Young Park
    Division of Reproductive Biology and Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:682-4. 2004
  6. ncbi Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer
    Evangelos G Papanikolaou
    Centre for Reproductive Medicine, University Hospital, Vrije Univestiteit Brussel, Free University of Brussels, Brussels, Belgium
    Fertil Steril 91:949-52. 2009
  7. doi Hyperglycosylated human chorionic gonadotropin stimulates angiogenesis through TGF-β receptor activation
    Sarah Berndt
    Institut National de Santé et de Recherche Médicale INSERM Unité Mixte de Recherche en Santé 767, Paris, France
    FASEB J 27:1309-21. 2013
  8. pmc Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling
    Johanna Prast
    Department of Obstetrics and Fetal Maternal Medicine, Reproductive Biology Unit, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Endocrinology 149:979-87. 2008
  9. doi Expression and production of human chorionic gonadotropin (hCG) in the normal secretory endometrium: evidence of CGB7 and/or CGB6 beta hCG subunit gene expression
    Gerolf Zimmermann
    Department of Obstetrics and Gynecology, Division of Human Reproduction and Endocrinology, University of Leipzig, Leipzig, Germany
    Biol Reprod 86:87. 2012
  10. ncbi Quad screen as a predictor of adverse pregnancy outcome
    Lorraine Dugoff
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Obstet Gynecol 106:260-7. 2005

Detail Information

Publications359 found, 100 shown here

  1. ncbi Characterization of human chorionic gonadotropin as a novel angiogenic factor
    Marek Zygmunt
    Department of Obstetrics and Gynecology, Justus Liebig University, Klinikstrasse 32, D 35385 Giessen, Germany
    J Clin Endocrinol Metab 87:5290-6. 2002
    ..Our data indicate a novel function for hCG in uterine adaptation to early pregnancy as well as in tumor development and underline the importance of hCG as an as yet unrecognized angiogenic factor...
  2. ncbi Human chorionic gonadotropin (hCG) may be a marker of systemic oxidative stress in normotensive and preeclamptic term pregnancies
    Abdelaziz Kharfi
    Département d obstétrique gynécologie, Centre Hospitalier Universitaire de Sherbrooke 3001, 12 e Avenue Nord, Sherbrooke, Quebec, Canada
    Clin Biochem 38:717-21. 2005
    In vitro studies on placental function have revealed interactions between levels of secretion of human chorionic gonadotropin (hCG) by trophoblastic cells and oxidative stress generated by hydrogen peroxide (H2O2)...
  3. ncbi 2nd-trimester maternal serum human chorionic gonadotropin and alpha-fetoprotein levels in male and female fetuses with Down syndrome
    Ofer Lehavi
    Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Israel
    Fetal Diagn Ther 20:235-8. 2005
    ..maternal serum alpha-fetoprotein (AFP) level is significantly lower and that the maternal serum human chorionic gonadotropin (hCG) level is significantly higher in the presence of a female fetus...
  4. doi Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression
    I Van Vaerenbergh
    Vrije Universiteit Brussel and UZ Brussel, Department of Pathology, Jette, Belgium
    Reprod Biomed Online 22:263-71. 2011
    ..5 ng/ml on the day of HCG administration...
  5. ncbi EGF-like growth factors as mediators of LH action in the ovulatory follicle
    Jy Young Park
    Division of Reproductive Biology and Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:682-4. 2004
    ..Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle...
  6. ncbi Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer
    Evangelos G Papanikolaou
    Centre for Reproductive Medicine, University Hospital, Vrije Univestiteit Brussel, Free University of Brussels, Brussels, Belgium
    Fertil Steril 91:949-52. 2009
    ..On the contrary, premature luteinization in the blastocyst subgroup had no effect on the pregnancy outcome...
  7. doi Hyperglycosylated human chorionic gonadotropin stimulates angiogenesis through TGF-β receptor activation
    Sarah Berndt
    Institut National de Santé et de Recherche Médicale INSERM Unité Mixte de Recherche en Santé 767, Paris, France
    FASEB J 27:1309-21. 2013
    ..Embryo implantation requires extensive angiogenesis at the maternal-fetal interface. Hyperglycosylated human chorionic gonadotropin (hCG-H), a trophoblast invasive signal produced by extravillous cytotrophoblasts and by choriocarcinoma, ..
  8. pmc Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling
    Johanna Prast
    Department of Obstetrics and Fetal Maternal Medicine, Reproductive Biology Unit, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Endocrinology 149:979-87. 2008
    b>Chorionic gonadotropin (CG) is indispensable for human pregnancy because it controls implantation, decidualization, and placental development...
  9. doi Expression and production of human chorionic gonadotropin (hCG) in the normal secretory endometrium: evidence of CGB7 and/or CGB6 beta hCG subunit gene expression
    Gerolf Zimmermann
    Department of Obstetrics and Gynecology, Division of Human Reproduction and Endocrinology, University of Leipzig, Leipzig, Germany
    Biol Reprod 86:87. 2012
    ..and CGA subunit mRNA gene expression as well as the expression of their dimeric and single-subunit human chorionic gonadotropin (hCG) proteins in normal secretory transformed endometrium...
  10. ncbi Quad screen as a predictor of adverse pregnancy outcome
    Lorraine Dugoff
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Obstet Gynecol 106:260-7. 2005
    ....
  11. ncbi The lutropin/choriogonadotropin receptor, a 2002 perspective
    Mario Ascoli
    Department of Pharmacology, The University of Iowa, Iowa City, 52242 1109, USA
    Endocr Rev 23:141-74. 2002
    ..As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor...
  12. ncbi Lanosterol 14alpha-demethylase expression in the mouse ovary and its participation in cumulus-enclosed oocyte spontaneous meiotic maturation in vitro
    Chao Wang
    Department of Animal Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, PR China
    Theriogenology 66:1156-64. 2006
    ....
  13. doi Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles
    E Bosch
    Department of Reproduction, Instituto Valenciano de Infertilidad, University of Valencia, Plaza de la Policia Local, 3, 46015 Valencia, Spain
    Hum Reprod 25:2092-100. 2010
    ..Efforts to resolve this question have been impeded by the various assays used to measure progesterone and the different, arbitrary threshold values for defining 'high' progesterone levels...
  14. pmc Periovulatory expression of hyaluronan and proteoglycan link protein 1 (Hapln1) in the rat ovary: hormonal regulation and potential function
    Jing Liu
    Department of Obstetrics and Gynecology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Mol Endocrinol 24:1203-17. 2010
    ..determined the periovulatory expression pattern of Hapln1 using pregnant mare serum gonadotropin/human chorionic gonadotropin (PMSG/hCG)-primed immature rat ovaries...
  15. doi The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins
    Kristina Orendi
    Institute of Cell Biology, Histology and Embryology, Centre for Molecular Medicine, Medical University of Graz, Harrachgasse 21 VII, 8010 Graz, Austria
    Reproduction 140:759-66. 2010
    ..The β subunit of human chorionic gonadotropin (CGB), placental alkaline phosphatase as well as placental protein 13 (PP13, LGALS13) are exclusively ..
  16. ncbi Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilizatio
    Nicole G M Beckers
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:4186-92. 2003
    ..Hence, support of corpus luteum function remains mandatory after ovarian stimulation for IVF with GnRH antagonist cotreatment...
  17. pmc Review: hCG, preeclampsia and regulatory T cells
    W Norris
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    Placenta 32:S182-5. 2011
    Human chorionic gonadotropin (hCG) is crucial for successful pregnancy. Its many functions include angiogenesis and immune regulation. Despite years of research, the etiology of preeclampsia remains unknown...
  18. doi Glycoprotein and carbohydrate binding protein expression in the placenta in early pregnancy loss
    U Jeschke
    Department of Obstetrics and Gynecology, Maistrasse, Ludwig Maximilians University, 80377 Munich, Germany
    J Reprod Immunol 85:99-105. 2010
    ..Decreased expression of Gal-1 may partly explain disturbed trophoblast differentiation during early placentation leading to early pregnancy loss...
  19. pmc Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)
    H Hizaki
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 96:10501-6. 1999
    ..These results indicate that PGE(2) cooperates with gonadotropin to complete cumulus expansion for successful fertilization...
  20. ncbi Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells
    T Gudermann
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 267:4479-88. 1992
    ..Expression of the murine LHR in L cells led to the appearance of binding sites for human chorionic gonadotropin (hCG) with a Kd of 150 pM and an LH- and hCG-stimulable adenylyl cyclase activity (EC50 = 50-100 pM hCG)...
  21. ncbi Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients
    J Smitz
    Follicle Biology Laboratory and Center for Reproductive Medicine, Academisch Ziekenhuis Vrije Universiteit Brussel, Belgium
    Hum Reprod 22:676-87. 2007
    ..Highly purified menotrophin (HP-hMG) has been associated with fewer oocytes retrieved and a higher proportion of top-quality embryos compared with recombinant FSH (rFSH)...
  22. ncbi The use of LH activity to drive folliculogenesis: exploring uncharted territories in ovulation induction
    Marco Filicori
    Reproductive Endocrinology Center, University of Bologna, Bologna, Italy
    Hum Reprod Update 8:543-57. 2002
    ....
  23. ncbi Absence of exon 10 of the human luteinizing hormone (LH) receptor impairs LH, but not human chorionic gonadotropin action
    Thomas Muller
    Institute of Reproductive Medicine, University of Munster, D 48129 Munster, Germany
    J Clin Endocrinol Metab 88:2242-9. 2003
    The LH receptor (LHR) mediates the actions of LH and human chorionic gonadotropin (hCG). In vivo data showed that deletion of exon 10 does not affect hCG action, whereas LH action is impaired...
  24. ncbi A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report
    S K Goswami
    Institute of Reproductive Medicine, Salt Lake, Kolkata 700091, India
    Hum Reprod 19:2031-5. 2004
    ..Use of letrozole, a selective inhibitor of aromatase, reduces the gonadotrophin dose required to induce follicular maturation. We evaluated whether incorporation of letrozole could be an effective low-cost IVF protocol for poor responders...
  25. pmc CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 25:253-68. 2011
    ..Microarray analyses identified numerous C/EBPα/β target genes in equine chorionic gonadotropin (eCG)-human (h)CG-treated mice...
  26. ncbi Crystal structure of human chorionic gonadotropin
    A J Lapthorn
    Department of Chemistry, University of Glasgow, UK
    Nature 369:455-61. 1994
    The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot...
  27. ncbi Expression and activity of 25-hydroxyvitamin D-1 alpha-hydroxylase are restricted in cultures of human syncytiotrophoblast cells from preeclamptic pregnancies
    Lorenza Díaz
    Department of Reproductive Biology, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico Distrito Federal, 14000, Mexico
    J Clin Endocrinol Metab 87:3876-82. 2002
    ..These results support the role of placenta as a contributor to the abnormalities observed in calcium metabolism in PE...
  28. ncbi Human chorionic gonadotropin in maternal serum in relation to fetal gender and utero-placental blood flow
    Johan Arnt Steier
    Departments of Obstetrics and Gynecology and Biochemical Endocrinology, Haukeland University Hospital, University of Bergen, Bergen, Norway
    Acta Obstet Gynecol Scand 83:170-4. 2004
    To investigate whether fetal gender differences in human chorionic gonadotropin (hCG) in maternal serum and the presence of hCG receptors in the wall of the uterine arteries influence the utero-placental blood flow.
  29. ncbi Trophoblast differentiation in embryoid bodies derived from human embryonic stem cells
    Behzad Gerami-Naini
    Wisconsin National Primate Research Center, University of Wisconsin Madison, 53715 1299, USA
    Endocrinology 145:1517-24. 2004
    ..The levels of human chorionic gonadotropin (hCG), progesterone, and estradiol-17beta in medium from hES cell-derived EBs grown in suspension culture ..
  30. ncbi Ovarian age-related responsiveness to human chorionic gonadotropin
    Terhi Piltonen
    Department of Obstetrics and Gynecology, Oulu University Hospital, FIN 90014 Oulu, Finland
    J Clin Endocrinol Metab 88:3327-32. 2003
    ..changes in androgen secretion and ovarian capacity to synthesize/release androgens in response to human chorionic gonadotropin (hCG) stimulation, 44 healthy women (aged 20-44 yr) were investigated...
  31. doi Up-regulation of placental leptin by human chorionic gonadotropin
    Julieta L Maymó
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidas de Buenos Aires, Buenos Aires, Argentina
    Endocrinology 150:304-13. 2009
    ..In the present work, we have found that recombinant human chorionic gonadotropin (hCG) added to BeWo choriocarcinoma cell line showed a stimulatory effect on endogenous leptin expression, ..
  32. ncbi Elevated serum progesterone level on the day of human chorionic gonadotropin administration does not adversely affect implantation rates after intracytoplasmic sperm injection and embryo transfer
    B Urman
    Assisted Reproduction Unit, American Hospital of Istanbul, Turkey
    Fertil Steril 72:975-9. 1999
    ..To evaluate the association between serum P levels on the day of hCG administration and the outcome of intracytoplasmic sperm injection (ICSI)...
  33. ncbi Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis
    C A Venetis
    Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Papageoriou General Hospital, Aristotle University of Thessaloniki, Nea Efkarpia, Peripheral Road, Thessaloniki, Greece
    Hum Reprod Update 13:343-55. 2007
    ....
  34. ncbi Identification of novel genes regulated by chorionic gonadotropin in baboon endometrium during the window of implantation
    J R A Sherwin
    HCLD, Professor of Physiology, Director, Center for Women s Health and Reproduction, Department of Obstetrics and Gynecology, University of Illinois, 820 South Wood Street, Chicago, Illinois 60612 7313, USA
    Endocrinology 148:618-26. 2007
    b>Chorionic gonadotropin (CG) is an early embryo-derived signal that is known to support the corpus luteum...
  35. ncbi Selection of oocytes for in vitro maturation by brilliant cresyl blue staining: a study using the mouse model
    Yan Guang Wu
    Laboratory for Animal Reproduction and Embryology, College of Animal Science and Vet Medicine, Shandong Agricultural University, Tai an, Shandong, China
    Cell Res 17:722-31. 2007
    ..Taken together, the series of criteria described here would allow for better choices in selecting oocytes for better development...
  36. pmc Medians for second-trimester maternal serum markers: geographical differences and variation caused by median multiples-of-median equations
    G Vranken
    Analis NV, Leeuwerikstraat, Gent, Belgium
    J Clin Pathol 59:639-44. 2006
    ..age-specific mid-trimester normal medians for the prenatal serum markers alpha fetoprotein (AFP), human chorionic gonadotropin (HCG) and unconjugated oestriol (uE3) for a Belgian population by using the Beckman Coulter Access ..
  37. ncbi Serum adiponectin levels increase after human chorionic gonadotropin treatment during in vitro fertilization
    Yung Hsien Liu
    Department of Obstetrics and Gynecology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Gynecol Obstet Invest 62:61-5. 2006
    ..To determine whether or not serum adiponectin concentrations are influenced by ovarian hyperstimulation during in vitro fertilization (IVF)...
  38. pmc A comparison of patients with relapsed and chemo-refractory gestational trophoblastic neoplasia
    T Powles
    Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Hammersmith Hospitals Campus of Imperial College London, London, UK
    Br J Cancer 96:732-7. 2007
    ..01)). The outcome of patients with relapsed GTN is good. However, patients with primary chemo-refractory disease do poorly and novel therapies are required for this group of patients...
  39. doi Subtle progesterone rise on the day of human chorionic gonadotropin administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers
    Robert Ochsenkuhn
    Center for Reproductive Medicine, Munich, Germany
    Fertil Steril 98:347-54. 2012
    ....
  40. doi Human chorionic gonadotropin controls luteal vascular permeability via vascular endothelial growth factor by down-regulation of a cascade of adhesion proteins
    Daniel Herr
    Department of Obstetrics and Gynaecology, Ulm University Medical Centre, Ulm, Germany
    Fertil Steril 99:1749-58. 2013
    ..We investigated the role of vascular endothelial (VE)-cadherin, nectin 2, and claudin 5 as controllers of vascular endothelial cell permeability...
  41. ncbi The importance of mini-puberty for fertility in cryptorchidism
    Faruk Hadziselimovic
    Department of Pediatrics, Kindertagesklinik, Oristalstrasse, Liestal, Switzerland
    J Urol 174:1536-9; discussion 1538-9. 2005
    ..It induces the development and transformation of gonocytes into Ad spermatogonia, which is impaired in many cryptorchid testes. We examine the role of testosterone in the transformation and development of Ad spermatogonia...
  42. doi Elevated serum levels of interleukin-6, interleukin-1β and human chorionic gonadotropin in pre-eclampsia
    Michail Kalinderis
    First Department of Obstetrics and Gynaecology, Papageorgiou General Hospital, Medical School, Aristotle University of Thessaloniki, Greece
    Am J Reprod Immunol 66:468-75. 2011
    ..concentrations of two proinflammatory cytokines interleukin-6 (IL-6) and interleukin-1β (IL-1β) and to evaluate the possible interaction between them and human chorionic gonadotropin (hCG) in women with normotensive pregnancy and PE.
  43. pmc A comparison of human chorionic gonadotropin and luteinizing hormone releasing hormone on the induction of spermiation and amplexus in the American toad (Anaxyrus americanus)
    Andrew J Kouba
    Conservation and Research Department, Memphis Zoo, 2000 Prentiss Place, Memphis, TN 38112, USA
    Reprod Biol Endocrinol 10:59. 2012
    ..The purpose of our study was to compare the efficacy of two different hormones at various concentrations on sperm production, quantity and quality over time in order to optimize assisted breeding...
  44. doi Differential effects of urinary and recombinant chorionic gonadotropin on oxidative stress responses in decidualizing human endometrial stromal cells
    T Kajihara
    Department of Obstetrics and Gynecology, Saitama Medical University, Iruma gun, Saitama, Japan
    Placenta 32:592-7. 2011
    Human chorionic gonadotropin (hCG) is one of the earliest signals secreted by the implanting embryo. In addition to its well-known luteotropic function in early pregnancy, hCG also acts directly on decidualizing endometrium...
  45. ncbi Steroid receptor expression in late follicular phase endometrium in GnRH antagonist IVF cycles is already altered, indicating initiation of early luteal phase transformation in the absence of secretory changes
    Evangelos G Papanikolaou
    University Hospital, Dutch Speaking Brussels Free University, AZ VUB, Centre for Reproductive Medicine, Laarbeeklaaan 101, 1090 Jette, Brussels, Belgium
    Hum Reprod 20:1541-7. 2005
    ....
  46. ncbi Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles
    Evangelos G Papanikolaou
    Centre for Reproductive Medicine, University Hospital, Dutch Speaking Brussels Free University, Brussels, Belgium
    Fertil Steril 85:112-20. 2006
    ..To determine the incidence of ovarian hyperstimulation syndrome (OHSS) in a large series of GnRH antagonist-stimulated cycles and to assess the predictive value of E2 and the number of follicles on the day of hCG administration...
  47. pmc Treatment outcomes for 618 women with gestational trophoblastic tumours following a molar pregnancy at the Charing Cross Hospital, 2000-2009
    A Sita-Lumsden
    Department of Medical Oncology, Gestational Trophoblastic Disease Centre, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK
    Br J Cancer 107:1810-4. 2012
    ..Because of the rarity of the diagnosis, detailed structured information on prognosis, treatment escalations and outcome is limited...
  48. ncbi Triggering final oocyte maturation using different doses of human chorionic gonadotropin: a randomized pilot study in patients with polycystic ovary syndrome treated with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating horm
    Efstratios M Kolibianakis
    Centre for Reproductive Medicine, Vrije Universiteit Brussel, Brussels, Belgium
    Fertil Steril 88:1382-8. 2007
    To evaluate the effect of different human chorionic gonadotropin (hCG) doses on the ongoing pregnancy rates in patients with polycystic ovary syndrome (PCOS).
  49. ncbi Induction of trophinin in human endometrial surface epithelia by CGbeta and IL-1beta
    Kazuhiro Sugihara
    Cancer Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    FEBS Lett 582:197-202. 2008
    ..These results provide a mechanism for trophinin-mediated adhesion of human blastocyst to endometrium by a spatially and temporally restricted paracrine effect of hCG derived from the blastocyst...
  50. pmc Chorionic gonadotrophin regulates CXCR4 expression in human endometrium via E-series prostanoid receptor 2 signalling to PI3K-ERK1/2: implications for fetal-maternal crosstalk for embryo implantation
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 17:22-32. 2011
    ..Taken together, our data suggest that early embryonic signals may regulate fetal-maternal crosstalk in the human endometrium by inducing CXCR4 expression via the PGE₂-PTGER2-mediated induction of the EGFR, PI3K and ERK1/2 pathways...
  51. ncbi In vivo infusion of interleukin-1beta and chorionic gonadotropin induces endometrial changes that mimic early pregnancy events in the baboon
    Zuzana Strakova
    Department of Obstetrics and Gynecology, University of Illinois, 820 South Wood Street M C 808, Chicago, Illinois 60612 7313, USA
    Endocrinology 146:4097-104. 2005
    Both human chorionic gonadotropin (hCG) and IL-1beta induce changes in the endometrium that are associated with the establishment of pregnancy...
  52. ncbi The differential binding affinities of the luteinizing hormone (LH)/choriogonadotropin receptor for LH and choriogonadotropin are dictated by different extracellular domain residues
    Colette Galet
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, The University of Iowa, 2 319B Bowen Sciences Building, 51 Newton Road, Iowa City, IA 52242 1109, USA
    Mol Endocrinol 19:1263-76. 2005
    ..This finding has to be considered in future models of the interaction of LH/CG with the LHR...
  53. ncbi Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up
    Efstratios Kolibianakis
    Centre for Reproductive Medicine, Dutch Speaking Brussels Free University, Brussels, Belgium
    Fertil Steril 78:1025-9. 2002
    ..To assess the effect of ovarian stimulation with recombinant FSH, GnRH antagonists, and hCG on endometrial maturation on the day of oocyte pick-up...
  54. ncbi Coasting-what is the best formula?
    O Levinsohn-Tavor
    IVF and Infertility Unit, Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Hum Reprod 18:937-40. 2003
    ..5-63% respectively). A multicentre randomized prospective study would help to confirm the effectiveness of this approach...
  55. doi Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function
    Hui Wan
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    J Leukoc Biol 86:361-70. 2009
    ..Together, these data suggest that hCG contributes to the controlled inflammatory state of pregnancy by regulating Mphi proinflammatory function...
  56. ncbi Can serum HCG values be used in the differential diagnosis of pregnancy complicated by hypertension?
    Ayse Gurbuz
    Department of Obstetrics and Gynecology, Zeynep Kamil Women and Pediatric Diseases Education and Research Hospital, Istanbul, Turkey
    Hypertens Pregnancy 23:1-12. 2004
    The aim of our study is to determine whether the serum human chorionic gonadotropin (hCG) level is helpful in the differential diagnosis and in the clinical management and follow-up of preeclampsia, superimposed preeclampsia, and chronic ..
  57. doi Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis
    Rachel E Dickinson
    Department of Reproductive and DevelopmentalSciences, Division of Obstetrics and Gynaecology, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Endocrinology 150:2873-81. 2009
    ..function and the establishment of pregnancy through its interaction with the gonadotropins LH and human chorionic gonadotropin. We previously identified four splice variants of the LHR in human luteinized granulosa cells (LGCs) and ..
  58. doi Hormonal induction of spermiation, courting behavior and spawning in the southern bell frog, Litoria raniformis
    Reinier M Mann
    Centre for Ecotoxicology, Department of Environmental Sciences, University of Technology, Sydney, NSW, Australia
    Zoo Biol 29:774-82. 2010
    ..hormones, including Lucrin(®), another synthetic LHRH analog ([des-Gly(10), D-Ala(6)]-LHRH), human chorionic gonadotropin, progesterone, and a dopamine receptor antagonist failed to promote oviposition and spawning in females...
  59. doi Second trimester serum predictors of preterm birth in a population-based sample of low-risk pregnancies
    Laura L Jelliffe-Pawlowski
    Genetic Disease Screening Program, California Department of Public Health, Richmond, CA 94804, USA
    Prenat Diagn 30:727-33. 2010
    ..To examine the relationship between typically collected second trimester maternal serum biomarkers and preterm birth among pregnancies without intrauterine-growth-retardation or other specific risk factors...
  60. pmc Effects of deletion of the prolactin receptor on ovarian gene expression
    Isabelle Grosdemouge
    Molecular Endocrinology, INSERM U344 Faculté de Médecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    Reprod Biol Endocrinol 1:12. 2003
    ..These modifications lead to the decrease of LH receptor expression and consequently to a loss of the enzymatic cascades necessary to produce adequate levels of progesterone which are required for the maintenance of pregnancy...
  61. pmc Extragonadal actions of chorionic gonadotropin
    Prajna Banerjee
    Department of Medicine Oncology, Stanford University, Stanford, CA 94305, USA
    Rev Endocr Metab Disord 12:323-32. 2011
    The primary embryonic signal in primates is chorionic gonadotropin (CG, designated hCG in humans), that is classically associated with corpus luteum rescue and progesterone production...
  62. ncbi Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1)
    Yu Bang Wang
    Key Laboratory of Reproductive Medicine of Jiangsu Province, Institute of Toxicology, Nanjing Medical University, Nanjing, People s Republic of China
    J Toxicol Environ Health A 70:947-55. 2007
    ..Data indicate that MBP interfered with steroid hormone production by affecting StAR expression in MLTC-1 cells...
  63. ncbi Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review
    Seema Menon
    Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 87:481-4. 2007
    ..Successful medical management of an ectopic pregnancy is inversely associated with initial hCG level. The purpose of this publication is to assess whether there is a level of hCG above which failure rate substantially increases...
  64. ncbi Differential effects of inducers of syncytialization and apoptosis on BeWo and JEG-3 choriocarcinoma cells
    S Al-Nasiry
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    Hum Reprod 21:193-201. 2006
    ..The interactions of trophoblasts with the cytokine network at the fetomaternal interface determine the pathway the cell undertakes, e.g. proliferation, differentiation and apoptosis...
  65. ncbi Placental alkaline phosphatase (PLAP) staining and human chorionic gonadotropin (hCG) production in cultures of fresh and cryopreserved cytotrophoblasts isolated by CD9/MHC class I/MHC class II immunoelimination
    L J Guilbert
    Department of Medical Microbiology and Immunology, 6 25 HMRC, University of Alberta, Edmonton, AL T6G 0B8, Canada
    Placenta 28:348-9. 2007
    ..after isolation (fresh) were compared with cryopreserved and thawed cells (frozen) for production of human chorionic gonadotropin (hCG) and expression of placental alkaline phosphate (PLAP) after 4 h of culture...
  66. ncbi cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells
    M Faure
    Department of Pharmacology, University of California, San Francisco 94143
    J Biol Chem 269:7851-4. 1994
    ..These unexpected results in COS-7 cells show that G proteins and second messengers regulate the MAPK pathway differently in different cell types...
  67. pmc hCG, the wonder of today's science
    Laurence A Cole
    USA hCG Reference Service, Albuquerque NM 87104, USA
    Reprod Biol Endocrinol 10:24. 2012
    ..Secondly, hCG exists in 5 common forms. Finally, it has so many functions ranging from control of human pregnancy to human cancer. This review examines these molecules in detail...
  68. doi Identification of the high-risk patient for ovarian hyperstimulation syndrome
    Evangelos G Papanikolaou
    Assisted Reproduction Unit, 1st OB GYN Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Semin Reprod Med 28:458-62. 2010
    ..Exogenous human chorionic gonadotropin (hCG) administered for final oocyte maturation and endogenous hCG produced by a developing pregnancy are ..
  69. pmc Notch1 is regulated by chorionic gonadotropin and progesterone in endometrial stromal cells and modulates decidualization in primates
    Yalda Afshar
    Department of Physiology and Biophysics, University of Illinois, Chicago, Illinois 60607, USA
    Endocrinology 153:2884-96. 2012
    ..integrity is coordinated by ovarian hormones, namely, estrogens, progesterone, and the embryonic hormone chorionic gonadotropin (CG). These regulated events modulate the menstrual cycle and decidualization...
  70. ncbi A validation of the most commonly used protocol to predict the success of single-dose methotrexate in the treatment of ectopic pregnancy
    E Kirk
    Department of Obstetrics and Gynaecology, Early Pregnancy, Gynaecological Ultrasound and MAS Unit, St George s, University of London, London, UK
    Hum Reprod 22:858-63. 2007
    ..The aim of this study was to assess this protocol and to develop new rules that could be used to predict the outcome at an earlier stage...
  71. pmc Regulation and function of tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP3 in periovulatory rat granulosa cells
    Feixue Li
    Department of Obstetrics and Gynecology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Endocrinology 150:3903-12. 2009
    ..isolated from immature pregnant mare serum gonadotropin-primed (10 IU) rat ovaries and treated with human chorionic gonadotropin (hCG; 1 IU/ml)...
  72. doi Hyperglycosylated hCG is a marker of early human trophoblast invasion
    J Guibourdenche
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 767, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Paris, France
    J Clin Endocrinol Metab 95:E240-4. 2010
    Human chorionic gonadotropin (hCG) is the major pregnancy glycoprotein hormone whose maternal concentration and glycan structure change all along pregnancy...
  73. pmc A role for nuclear factor interleukin-3 (NFIL3), a critical transcriptional repressor, in down-regulation of periovulatory gene expression
    Feixue Li
    College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, People s Republic of China
    Mol Endocrinol 25:445-59. 2011
    ..Immature female rats were injected with pregnant mare's serum gonadotropin, treated with human chorionic gonadotropin (hCG), and ovaries or granulosa cells were collected at various times after hCG...
  74. pmc Ovarian hyperstimulation syndrome: pathophysiology and prevention
    Carolina O Nastri
    Departamento de Ginecologia e Obstetrícia da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo DGO HC FMRP USP, Avenida dos Bandeirantes 3900, 8 masculine Andar, Ribeirao Preto, Sao Paulo, Brazil, CEP 14049 900
    J Assist Reprod Genet 27:121-8. 2010
    ..To review and discuss the pathophysiology and prevention strategies for ovarian hyperstimulation syndrome (OHSS), which is a condition that may occur in up to 20% of the high risk women submitted to assisted reproductive technology cycles...
  75. pmc LH-induced neuregulin 1 (NRG1) type III transcripts control granulosa cell differentiation and oocyte maturation
    Noritaka Noma
    Laboratory of Reproductive Endocrinology, Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Hiroshima, Japan
    Mol Endocrinol 25:104-16. 2011
    ..The NRG1 pathway has two roles: one is to enhance AREG-induced progesterone production in granulosa cells, and the other is to regulate oocyte maturation by a cumulus cell-dependent mechanism...
  76. ncbi Low-dose HCG may improve pregnancy rates and lower OHSS in antagonist cycles: a meta-analysis
    I P Kosmas
    Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Ioannina University School of Medicine, Ioannina, Greece
    Reprod Biomed Online 19:619-30. 2009
    ..Low-dose HCG supplementation may improve pregnancy rates in antagonist protocols. Overall, low-dose HCG-supplemented protocols are a cost-effective strategy...
  77. doi Vascular endothelial growth factor and β-human chorionic gonadotropin are associated with trophoblastic invasion into the tubal wall in ectopic pregnancy
    Fabio Roberto Cabar
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Fertil Steril 94:1595-600. 2010
    ..To assess the association between the depth of trophoblastic penetration into the tubal wall with serum concentrations of vascular endothelial growth factor (VEGF) and β-hCG and to assess its predictive value...
  78. pmc The B cell translocation gene (BTG) family in the rat ovary: hormonal induction, regulation, and impact on cell cycle kinetics
    Feixue Li
    Department of Obstetrics and Gynecology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Endocrinology 150:3894-902. 2009
    ..Our findings suggest that the induction of the BTG family may be important for theca and granulosa cell differentiation into luteal cells by arresting cell cycle progression...
  79. ncbi Control of human luteal steroidogenesis
    Luigi Devoto
    Departamento de Obstetricia y Ginecologia, Facultad de Medicina, Instituto de Investigaciones Materno Infantil, IDIMI y Universidad de Chile, PO Box 226 3, Santiago, Chile
    Mol Cell Endocrinol 186:137-41. 2002
    ..During the mid-to-late luteal phase of a fertile cycle, chorionic gonadotropin (hCG) rescues the CL, overcoming the actions of the factors inducing luteolysis...
  80. ncbi Hormonal cryptorchidism therapy: systematic review with metanalysis of randomized clinical trials
    Márcia Riromi Henna
    Pediatr Surg Int 20:357-9. 2004
    ..Success rates of hormonal treatment vary: 0-55% with human chorionic gonadotropin (hCG) and 9-78% with gonadotropin-releasing hormone (GnRH)...
  81. ncbi Alterations in reproductive function in SRC tyrosine kinase knockout mice
    Katherine F Roby
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Endocrine 26:169-76. 2005
    ..Serum LH and FSH on d 40 and 52 of age did not differ between Src wild-type and knockout females. Results from these studies reveal that female Src knockout mice are infertile due to reduced follicle development and anovulation...
  82. ncbi hCG in trophoblast tumour cells of the cell line Jeg3 and hCG isolated from amniotic fluid and serum of pregnant women carry oligosaccharides of the sialyl Lewis X and sialyl Lewis a type
    Udo Jeschke
    University of Rostock, Department of Obstetrics and Gynaecology, Faculty of Medicine, Doberaner Str 142, D 18055 Rostock, Germany
    Anticancer Res 23:1087-92. 2003
    Human chorionic gonadotropin (hCG) is a placental hormone and marker for the differentiation process of cytotrophoblast cells to syncytial trophoblasts. It is secreted into the maternal circulation and urine...
  83. doi Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells
    Mikihiro Yoshie
    Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Hum Reprod 25:2229-38. 2010
    ..We examined the differential roles of Epac and protein kinase A (PKA) signaling in the cell fusion and differentiation of trophoblast-derived BeWo cells...
  84. doi Interplay of cAMP and MAPK pathways in hCG secretion and fusogenic gene expression in a trophoblast cell line
    M Delidaki
    Laboratory of GPCR Pathophysiology Research, Endocrinology and Metabolism, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    Mol Cell Endocrinol 332:213-20. 2011
    ..of adenylyl cyclase leads to increased expression of trophoblast fusogenic gene machinery and human chorionic gonadotropin (hCG) secretion...
  85. doi Can 200 IU of hCG replace recombinant FSH in the late follicular phase in a GnRH-antagonist cycle? A pilot study
    C Blockeel
    Centre for Reproductive Medicine, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Hum Reprod 24:2910-6. 2009
    ..This randomised controlled trial (RCT) further explored whether low-dose hCG can be used clinically to replace recombinant FSH (rFSH) during the late follicular phase in a GnRH-antagonist protocol...
  86. doi Triggering with human chorionic gonadotropin or a gonadotropin-releasing hormone agonist in gonadotropin-releasing hormone antagonist-treated oocyte donor cycles: findings of a large retrospective cohort study
    Daniel Bodri
    Clinica Eugin, Barcelona, Spain
    Fertil Steril 91:365-71. 2009
    ..To compare pregnancy rates and the incidence of ovarian hyperstimulation syndrome (OHSS) in donor stimulation cycles where final maturation of oocytes was induced with recombinant hCG or GnRH agonist...
  87. ncbi Biological activities of tethered equine chorionic gonadotropin (eCG) and its deglycosylated mutants
    Kwan Sik Min
    Laboratory of Cellular Biochemistry, Animal Resource Sciences Veterinary Medical Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    J Reprod Dev 50:297-304. 2004
    Equine chorionic gonadotropin (eCG), which consists of highly glycosylated alpha- and beta-subunits, is a unique member of the gonadotropin family because it elicits response characteristics of both follicle-stimulating hormone (FSH) and ..
  88. doi 1,500 IU human chorionic gonadotropin administered at oocyte retrieval rescues the luteal phase when gonadotropin-releasing hormone agonist is used for ovulation induction: a prospective, randomized, controlled study
    Peter Humaidan
    The Fertility Clinic, Skive Regional Hospital, Resenvej 25, 7800 Skive, Denmark
    Fertil Steril 93:847-54. 2010
    ..To prospectively assess the reproductive outcome with a small bolus of hCG administered on the day of oocyte retrieval after ovulation induction with a GnRH agonist (GnRHa)...
  89. doi Targeting the vascular endothelial growth factor system to prevent ovarian hyperstimulation syndrome
    Sergio Reis Soares
    Instituto Valenciano de Infertilidad, IVI Lisboa Av Infante Dom Henrique, 333 H, 1800 282 Lisbon, Portugal
    Hum Reprod Update 14:321-33. 2008
    ..Ovarian hyperstimulation syndrome (OHSS) typically occurs when ovaries are primed with FSH/LH and subsequently exposed to hCG. The ultimate pathophysiological step underlying this clinical picture is increased vascular permeability (VP)...
  90. ncbi Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium
    Sarah Berndt
    Laboratory of Tumor and Development Biology, Centre de Recherche en cancérologie Expérimentale, Universite de Liege, Liege, Belgium
    FASEB J 20:2630-2. 2006
    ..VEGF and hCG also displayed additive activities. Altogether, these data demonstrate that peritrophoblastic angiostimulation may result from a paracrine dialogue between trophoblast, epithelial, and endothelial cells through hCG and VEGF...
  91. pmc Chorionic gonadotropin regulates prostaglandin E synthase via a phosphatidylinositol 3-kinase-extracellular regulatory kinase pathway in a human endometrial epithelial cell line: implications for endometrial responses for embryo implantation
    Prajna Banerjee
    Department of Physiology and Biophysics, University of Illinois, Chicago, Illinois 60612, USA
    Endocrinology 150:4326-37. 2009
    ..Infusion of chorionic gonadotropin (CG) into the oviducts of baboons to mimic embryo transit induces a myriad of morphological, biochemical, ..
  92. ncbi Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system
    Umit A Kayisli
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Immunol 171:2305-13. 2003
    The first known hormonal signal of the conceptus during implantation is human chorionic gonadotropin (hCG). Interestingly, increased apoptosis in human endometrium coincides with the implantation window...
  93. ncbi Hormones and human trophoblast differentiation: a review
    Andre Malassine
    INSERM U427, Faculte de Pharmacie, Paris, France
    Endocrine 19:3-11. 2002
    ..of villous trophoblast are specifically stimulated by estradiol, glucocorticoids, and human chorionic gonadotropin (hCG) whereas progesterone is ineffective...
  94. ncbi Interleukin-1beta-induced expression of IL-6 and production of human chorionic gonadotropin in human trophoblast cells via nuclear factor-kappaB activation
    Satoru Tsukihara
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    Am J Reprod Immunol 52:218-23. 2004
    ..The purpose of this study was to examine the role of nuclear factor-kappaB (NF-kappaB) during the induction of IL-6 by IL-1beta in human trophoblast cells...
  95. ncbi Choriocarcinoma. A model for tumour markers
    K D Bagshawe
    Department of Medical Oncology, Charing Cross Hospital, London, England
    Acta Oncol 31:99-106. 1992
    ....
  96. doi Human chorionic gonadotropin stimulates matrix metalloproteinases-2 and -9 in cytotrophoblastic cells and decreases tissue inhibitor of metalloproteinases-1, -2, and -3 in decidualized endometrial stromal cells
    Herbert Fluhr
    Department of Obstetrics and Gynecology, University of Greifswald, Greifswald, Germany
    Fertil Steril 90:1390-5. 2008
    ..To investigate the influence of hCG on trophoblastic matrix metalloproteinases (MMPs) -2 and -9 as well as endometrial tissue inhibitor of metalloproteinases (TIMPs) -1, -2, and -3...
  97. pmc Differences in apoptotic susceptibility of cytotrophoblasts and syncytiotrophoblasts in normal pregnancy to those complicated with preeclampsia and intrauterine growth restriction
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Manchester, UK
    Am J Pathol 162:637-43. 2003
    ..This is the first description of enhanced apoptosis in isolated villous trophoblasts in PE and IUGR. These intrinsic differences may represent an important factor in the pathophysiology of these conditions...
  98. ncbi Criteria of a successful coasting protocol for the prevention of severe ovarian hyperstimulation syndrome
    Ragaa Mansour
    The Egyptian IVF ET Center, 3, Road 161 Hadayek El Maadi, Cairo 11431, Egypt
    Hum Reprod 20:3167-72. 2005
    ..The aim of this study is to report a large series of patients (n = 1223) at risk of developing ovarian hyperstimulation syndrome (OHSS) who underwent coasting...
  99. ncbi Gonadotrophin stimulation of non-luteinized granulosa cells increases steroid production and the expression of enzymes involved in estrogen and progesterone synthesis
    M Lindeberg
    Department of Clinical Science Investigation and Technology, Division of Obstetrics and Gynecology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Hum Reprod 22:401-6. 2007
    ..When in vitro maturation (IVM) of the oocytes is performed, non-luteinized GCs can be collected. We have investigated how these cells respond to gonadotrophin stimulation in culture...
  100. doi Human chorionic gonadotropin: a hormone with immunological and angiogenic properties
    Marie Tsampalas
    University of Liege, Centre of Immunology, CHU B 23, B 4000 Liege, Belgium
    J Reprod Immunol 85:93-8. 2010
    ..The first known human embryo-derived signal is chorionic gonadotropin (hCG) by which the embryo profoundly influences immunological tolerance and angiogenesis at the maternal-..
  101. doi Chorionic gonadotropin stimulation of angiogenesis and pericyte recruitment
    Sarah Berndt
    Department of Obstetrics and Gynecology, Centre Hospitalier Regional, Laboratory of Tumor and Development Biology, University of Liege, B 4000 Liege, Belgium
    J Clin Endocrinol Metab 94:4567-74. 2009
    During the periimplantation period, human chorionic gonadotropin (hCG) plays a key role by increasing the uterine blood flow through uterine vessel vasodilatation but also through angiogenesis...

Research Grants64

  1. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..at the end of non-conception cycles, and whether LXR agonist replacement can reverse the effects of chorionic gonadotropin (CG)...
  2. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..hormones during mid-gestation indicative of stress (CRH, dehydroepiandrosterone-sulfate (DHEA-S), human chorionic gonadotropin (hCG), and bioactive androgens);and high levels of pro- inflammatory cytokines (interleukine (IL)-1p, IL-6 ..
  3. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    ..including (1) Reproductive Hormones: pregnanediol-3-glucuronide (PdG), estrone conjugate (E1C), and human chorionic gonadotropin (b-hCG) assessed in daily first void urine samples of prospectively observed menstrual cycles;(2) ..
  4. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..the rhesus macaque follicle from undetectable levels before administration of an ovulatory stimulus (human chorionic gonadotropin;hCG;0 h controls) to peak values prior to (12 h post-hCG) and following ovulation (36 h post-hCG)...
  5. Hormonal and Paracrine Regulation of Spermatogenesis
    Barry R Zirkin; Fiscal Year: 2010
    ..contraceptive doses of T, and will determine the quantitative relationship between hCG [human chorionic gonadotropin]-induced intratesticular bioactive androgens and spermatogenesis...
  6. Functional Significance of the HIF1 Transcriptome in Granulosa Cells
    John H Nilson; Fiscal Year: 2013
    ..Moreover, understanding how FSH signals to direct follicular maturation can translate into safer and more effective treatments of infertility and early pregnancy loss as well as new approaches for contraceptive drugs. ..
  7. Modulation of the Receptive Endometrium by CG
    Asgerally T Fazleabas; Fiscal Year: 2013
    ..During the previous funding period we demonstrated that the early primate embryonic signal, chorionic gonadotropin (CG), coupled with progesterone, directly modulates endometrial gene expression and alters the ..
  8. Aptamer-based Glycomics Tools
    Binghe Wang; Fiscal Year: 2010
    ..We will also work on human chorionic gonadotropin (hCG), which has many glycosylation sites...
  9. Human Choriogonadotropin Signaling in Cell Proliferation
    MICHAEL HUDECKI; Fiscal Year: 2003
    ..abstract_text> ..
  10. PRENATAL DOWN SYNDROME SCREENING
    Rachel Fisher; Fiscal Year: 1993
    ..Human Beta chorionic gonadotropin (BetahCG) levels tend to be raised, [5-8] and unconjugated estriol (UE) levels tend to be lowered [9,10]...
  11. MEMBRANE EVENTS FOLLOWING HORMONE BINDING TO LH RECEPTOR
    DEBORAH ROESS; Fiscal Year: 1991
    In humans, luteinizing hormone (LH) and human chorionic gonadotropin (hCG) regulate the secretion of progesterone from the corpus luteum during the menstrual cycle and early pregnancy...
  12. Transcription Factors in Trophectoderm Differentiation
    Robert Roberts; Fiscal Year: 2007
    The early production of human chorionic gonadotropin (hCG) by the trophoblast is essential to rescuing the corpus luteum and maintaining production of progesterone in early pregnancy...
  13. Regulation of Gene Expression During Spermatogenesis
    Peter Petrusz; Fiscal Year: 2004
    ..As additional controls, a set of the transgenic animals will be treated with human chorionic gonadotropin. This treatment is known to increase intratesticular androgen concentration and should reverse the changes ..
  14. STRUCTURE AND FUNCTION OF THE LH AND FSH RECEPTORS
    Deborah Segaloff; Fiscal Year: 2002
    ..Long term goals of research in this area include the ability to better understand, diagnose, and correct reproductive disorders. ..
  15. STRATEGIES FOR PRIMATE TRANSGENESIS
    Thaddeus Golos; Fiscal Year: 2003
    ..We will use the chorionic gonadotropin alpha subunit promoter to direct transgene expression to the placenta as a model system for the tissue-..
  16. O-GLYCOSYLATION OF HCG AND CANCER
    Laurence Cole; Fiscal Year: 1993
    Human chorionic gonadotropin (hCG) is produced by the trophoblast in pregnancy, mole and choriocarcinoma...
  17. REGULATION OF OTP-1 AND HCG GENES IN OVINE TROPHOBLAST
    George Seidel; Fiscal Year: 1993
    ..have been identified: in sheep, ovine trophoblast protein-1 (oTP-1); cattle, (bTP- 1); and humans, human chorionic gonadotropin (hCG)...
  18. INTERACTION AND ACTIVATION OF THE LH RECEPTOR
    TAE JI; Fiscal Year: 2005
    Luteinizing hormone(LH) and human chorionic gonadotropin (hCG) bind to the same receptor (LHR). These hormones and LHR play crucial roles in reproduction, women's health and some ovarian and prostate cancers...
  19. TROPHOBLAST PROLIFERATION AND GROWTH FACTOR EXPRESSION
    Robert Taylor; Fiscal Year: 1991
    ..g. PDGF, human chorionic gonadotropin [hCG], thrombin, pregnancy serum, steroid hormones) to modulate c-sis, c-myc, and PDGF-R expression in ..
  20. MOLECULAR ENDOCRINOLOGY OF THE UTERUS
    Elizabeth Stewart; Fiscal Year: 2001
    DESCRIPTION: (Adapted from applicant's description) The glycoprotein hormone human chorionic gonadotropin (hCG) has been demonstrated to have direct effects on uterine metabolism...
  21. BIOCHEMICAL STUDIES ON THE LH-HCG RECEPTOR
    Brij Saxena; Fiscal Year: 1990
    A receptor preparation specific to luteinizing hormone and to human chorionic gonadotropin has been isolated from bovine corpora lutea and is available in our laboratory in sufficient quantities to permit biochemical, structural and ..
  22. GLYCOPROTEIN HORMONE ALPHA SUBUNIT & GENE TRANSCRIPTION
    PAMELA MELLON; Fiscal Year: 1992
    ..b>Chorionic gonadotropin (CG) is responsible for the maintenance of pregnancy and luteinizing hormone (LH) and follicle stimulating ..
  23. THE PHYSIOLOGY OF PLACENTAL LACTOGEN
    Stuart Handwerger; Fiscal Year: 2006
    ..cultures of villous cytotrophoblast cells, using the induction of human placental lactogen (hPL), human chorionic gonadotropin (hCG) and several other genes as fundamental markers of syncytiotrophoblast cell development...
  24. EFFECTS OF VITAMIN D DEFICIENCY ON MALE REPRODUCTION
    GARY KWIECINSKI; Fiscal Year: 1992
    ..circulating T concentrations are low in vitamin D-deficient animals, stimulation of T synthesis with human chorionic gonadotropin infusions and the restoration of normal fertility with T implants will be attempted, 3) to determine if ..
  25. ROLE OF BETA ARRESTIN IN LH/CG RECEPTOR DESENSITIZATION
    MARY HUNZICKER DUNN; Fiscal Year: 2004
    ....
  26. REGULATION OF HUMAN PLACENTAL GROWTH BY IGFS
    Michael Fant; Fiscal Year: 1993
    ..e. chorionic gonadotropin (HCG) and placental lactogen (hPL)...
  27. LONG ACTING GONADOTROPIN
    William Moyle; Fiscal Year: 1999
    ..It is now possible to design analogs of human chorionic gonadotropin (hCG) that retain virtually the entire structure of hCG but that function more like FSH...
  28. Genomic Fingerprint of PGF2alpha and LH actions on the *
    Rajagopala Sridaran; Fiscal Year: 2006
    ..Also, the mechanism by which the life-span of the CL gets extended by the chorionic gonadotropin (CG), a functional analog of pituitary LH, elaborated by the placental trophoblast in fertile menstrual ..
  29. GONADOTROPINS
    Harold Papkoff; Fiscal Year: 1990
    ..highly purified equine and related species of luteinizing hormone, follicle stimulating hormone and chorionic gonadotropin. In vitro bioassays, radioreceptor assays and radioimmunoassays are used to obtain structure-function ..
  30. LONG-TERM CAPTIVE REPRODUCTION OF AOTUS TRIVIRGATUS
    JOHN STRANDBERG; Fiscal Year: 1980
    ..Pregnancy will be monitored by recognizing chorionic gonadotropin in the urine using the non-human primate pregnancy test...
  31. CHORIONIC GONADOTROPIN CHEMISTRY/REPRODUCTIVE BIOLOGY
    Robert Canfield; Fiscal Year: 1980
    ..research proposed here is to continue an established program of studies related to the chemistry of human chorionic gonadotropin (hCG) placing new emphasis on these elements of immunochemistry that relate to potential applications in ..
  32. PROTEIN STRUCTURE/FUNCTION RELATIONSHIPS
    LEE BULLA; Fiscal Year: 1993
    ..Certainly, the administration and faculty involved are committed to this cause...
  33. NOVEL THERAPY FOR KAPOSI'S SARCOMA
    JAMES LARRICK; Fiscal Year: 2000
    ..eosinophil-derived neurotoxin [EDN(-4)], accounts for much of the cytotoxic activity of crude human chorionic gonadotropin for Kaposi's sarcoma cells ...
  34. STRUCTURE-FUNCTION STUDIES OF GONADOTROPINS
    Irving Boime; Fiscal Year: 1991
    The human placental hormone chorionic gonadotropin (hCG) together with the pituitary hormones lutropin (LH), follitropin (FSH), and thyrotropin (TSH) constitute a family of glycoprotein hormones of dimeric structure containing 2 ..
  35. ORGANIZATION OF LH RECEPTORS ON HORMONE RESPONSIVE CELLS
    DEBORAH ROESS; Fiscal Year: 1999
    Dr. Roess' research has involved the study of luteinizing hormone/chorionic gonadotropin (LH/CG) receptor organization and how this organization modulates receptor function...
  36. NIS Regulation in Breast Cancer
    Sissy Jhiang; Fiscal Year: 2005
    ..Determine the mechanism of NIS up-regulation by human chorionic gonadotropin (hCG), trans-retinoic acid (tRA), and cyclooxygenase-2 (Cox-2) in human breast cancer cells; Aim 2...
  37. Obesity, Leptin Resistance and Ovarian Function in Mice
    Maureen Diggins; Fiscal Year: 2003
    ..Ovaries will be stimulated with equine chorionic gonadotropin (eCG) and ovulation induced with human chorionic gonadotropin (hCG)...
  38. Pre-mRNA Trans-Splicing for Molecular Imaging of Cancer
    GERARD MC GARRITY; Fiscal Year: 2003
    ..We propose studies to target cancer specific or cancer associated genes: human papillomavirus, human chorionic gonadotropin and EGF receptor with PTMs encoding marker luciferase exons...
  39. GONADOTROPIN PHYSICAL CHEMISTRY
    JOYCE LUSTBADER; Fiscal Year: 2000
    The primary focus of this proposal is to determine the three-dimensional structure of human chorionic gonadotropin and its receptor...
  40. Pregnancy-Associated Horomones and Immune to Malaria
    Diane Taylor; Fiscal Year: 2006
    ..and how specific hormones might down-regulate them, we developed a hypothetical model to explain how human chorionic gonadotropin, cortisol and prolactin might interact to suppress immune responses that result in susceptibility to ..
  41. HCG IN NORMAL HUMANS
    WILLIAM ODELL; Fiscal Year: 1990
    ..antibody sandwich type assays for human thyrotropin, human luteinizing hormone (hLH), human chorionic gonadotropin (hCG), and human prolactin...
  42. LACTATION INDUCED REDUCTION IN BREAST CANCER RISK
    David Kiang; Fiscal Year: 1999
    ..in life are associated with a reduced risk of human breast cancer, while pseudopregnancy induced by human chorionic gonadotropin (hCG) has a protective effect against mammary tumorigenesis in rats...
  43. SURFACE PLASMON IMMUNOASSAY FOR MEASUREMENT OF HCG
    Eduardo Fontana; Fiscal Year: 1991
    ..During this stage of the research, human chorionic gonadotropin (HCG), will be used as a model hormone to characterize the assay performance in terms of sensitivity, ..
  44. URINARY HCG EXPRESSION IN PREGNANCY LOSS
    JOHN O CONNOR; Fiscal Year: 1993
    ..Its determination requires the measurement of urinary human chorionic gonadotropin (hCG)...
  45. IMMUNOFLUOROMETRIC ASSAY FOR REPRODUCTIVE HORMONES
    Salvador Fernandez; Fiscal Year: 1992
    ..Phase II multiple analyte capability will be investigated for hormones of clinical interest such as human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, progesterone, estradiol ..
  46. CHEMICAL STUDIES OF HORMONES AND METABOLIC DISORDERS
    Robert Canfield; Fiscal Year: 1980
    An objective of the proposed research is (1) to conduct studies of the chemistry of the hormone, human chorionic gonadotropin, (2) to study its biosynthesis to seek any precursor forms and (3) to identify antigenic determinants of the ..
  47. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003
    ..This may provide insight into the mechanisms leading to infertility (e.g., leuteinized unruptured follice syndrome) and support the developoment of PG synthesis inhibitors of PG synthesis inhibitors for use as contraceptives. ..
  48. CELL SUBPOPULATIONS IN THE PRIMATE CORPUS LUTEUM
    Richard Stouffer; Fiscal Year: 2001
    ..Overall, the proposed research may have relevance to an understanding of certain ovarian disorders such as ovarian hyperstimulation syndrome and luteal phase defects where microvasculature growth may be disrupted. ..
  49. Inhibin/Activin Family in Human Cranifocial Development
    Geralyn Messerlian; Fiscal Year: 2003
    ..abstract_text> ..
  50. Imaging Cell Signaling Events During Luteinizing Hormone Pulses
    DEBORAH ROESS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  51. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt T Barnhart; Fiscal Year: 2010
    ....
  52. MEMBRANE EVENTS FOLLOWING HORMONE BINDING TO LH RECEPTOR
    DEBORAH ROESS; Fiscal Year: 2005
    ..Colin Clay, a member of the Animal Reproduction and Biotechnology Laboratory, and of Dr. Michael Tamkun, a neurobiologist at Colorado State University. ..
  53. LH Receptor C-terminus in Receptor Desensitization
    DEBORAH ROESS; Fiscal Year: 2003
    ..Brief exposure to either LH or human chorionic gonadotropin (hCG) causes LH receptor desensitization and clustering of LH receptors in large, microscopically-visible ..
  54. The function of Runx1 in the ovary
    Misung Jo; Fiscal Year: 2007
    ..Such knowledge can be applied for promoting or inhibiting these critical facets of ovarian physiology, thereby allowing us to better manage fertility, infertility, and ovarian-based disorders. [unreadable] [unreadable]..
  55. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    Joanne Richards; Fiscal Year: 2007
    ..A related and longer term goal of the research is to identify and characterize the genes regulated by LH, prostaglandins (PGs), and C/EBPs that control key steps in the ovulatory process. ..
  56. 2004 Reproductive Tract Biology Gordon Conference
    Asgerally Fazleabas; Fiscal Year: 2004
    ..The continued ability to meet with the Mammalian Gametogenesis and Embryogenesis Conference at the same site will further enhance the quality of this meeting, which has consistently been highly rated by the attendees. ..