gonadotropins

Summary

Summary: Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.

Top Publications

  1. doi Perspectives on fish gonadotropins and their receptors
    B Levavi-Sivan
    The Robert H Smith Faculty of Agriculture, Food and Environment, Department of Animal Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Gen Comp Endocrinol 165:412-37. 2010
  2. ncbi Expression of ER-alpha and ER-beta in the hamster ovary: differential regulation by gonadotropins and ovarian steroid hormones
    Peixin Yang
    Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4515, USA
    Endocrinology 143:2385-98. 2002
  3. ncbi Regulation of gonadotropins by inhibin and activin
    Susan J Gregory
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Semin Reprod Med 22:253-67. 2004
  4. doi Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial
    Francisco Fábregues
    Institut Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Faculty of Medicine University of Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Hum Reprod 24:349-59. 2009
  5. ncbi Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice
    P J Baker
    Division of Veterinary Physiology and Pharmacology, Department of Veterinary Preclinical Studies, University of Glasgow Veterinary School, Bearsden Rd, Glasgow G61 1QH, UK
    Reproduction 122:227-34. 2001
  6. ncbi Regulation of gonadotropin subunit gene transcription
    L L Burger
    Division of Endocrinology, Department of Internal Medicine and the Center for Research in Reproduction, University of Virginia, Charlottesville, VA 22908, USA
    J Mol Endocrinol 33:559-84. 2004
  7. pmc Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits
    Kathryn J Bryan
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurochem 112:870-81. 2010
  8. ncbi Clinical management of low ovarian response to stimulation for IVF: a systematic review
    B C Tarlatzis
    Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Greece
    Hum Reprod Update 9:61-76. 2003
  9. pmc Studies in zebrafish reveal unusual cellular expression patterns of gonadotropin receptor messenger ribonucleic acids in the testis and unexpected functional differentiation of the gonadotropins
    Angel García-López
    Department of Biology, Division of Endocrinology and Metabolism, Utrecht University, Faculty of Science, Utrecht, The Netherlands
    Endocrinology 151:2349-60. 2010
  10. pmc Gonadotropins regulate rat testicular tight junctions in vivo
    Mark J McCabe
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Victoria, Australia
    Endocrinology 151:2911-22. 2010

Detail Information

Publications294 found, 100 shown here

  1. doi Perspectives on fish gonadotropins and their receptors
    B Levavi-Sivan
    The Robert H Smith Faculty of Agriculture, Food and Environment, Department of Animal Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Gen Comp Endocrinol 165:412-37. 2010
    ..The various cell types in the teleost pituitary are organized in discrete domains. Fish possess two gonadotropins (GtH) similar to FSH and LH in other vertebrates; they are heterodimeric hormones that consist of a common ..
  2. ncbi Expression of ER-alpha and ER-beta in the hamster ovary: differential regulation by gonadotropins and ovarian steroid hormones
    Peixin Yang
    Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4515, USA
    Endocrinology 143:2385-98. 2002
    ..ER expression was stimulated by estrogen, but progesterone strongly inhibited estrogen action. These results indicate that ER expression is cell type specific to the larger extent and is critically regulated by reproductive hormones...
  3. ncbi Regulation of gonadotropins by inhibin and activin
    Susan J Gregory
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Semin Reprod Med 22:253-67. 2004
    ..These proteins can effect the regulation of the gonadotropins at many levels...
  4. doi Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial
    Francisco Fábregues
    Institut Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Faculty of Medicine University of Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Hum Reprod 24:349-59. 2009
    ..Studies in macaques have indicated that androgens have some synergistic effects with FSH on folliculogenesis. This study investigated the usefulness of pretreatment with transdermal testosterone in low-responder IVF patients...
  5. ncbi Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice
    P J Baker
    Division of Veterinary Physiology and Pharmacology, Department of Veterinary Preclinical Studies, University of Glasgow Veterinary School, Bearsden Rd, Glasgow G61 1QH, UK
    Reproduction 122:227-34. 2001
    ....
  6. ncbi Regulation of gonadotropin subunit gene transcription
    L L Burger
    Division of Endocrinology, Department of Internal Medicine and the Center for Research in Reproduction, University of Virginia, Charlottesville, VA 22908, USA
    J Mol Endocrinol 33:559-84. 2004
    Reproductive function in mammals is regulated by the pituitary gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH)...
  7. pmc Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits
    Kathryn J Bryan
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurochem 112:870-81. 2010
    Declining levels of estrogen in women result in increases in gonadotropins such as luteinizing hormone (LH) through loss of feedback inhibition. LH, like estrogen, is modulated by hormone replacement therapy...
  8. ncbi Clinical management of low ovarian response to stimulation for IVF: a systematic review
    B C Tarlatzis
    Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Greece
    Hum Reprod Update 9:61-76. 2003
    ..Well-designed, large-scale, randomized, controlled trials are needed to assess the efficacy of these different management strategies...
  9. pmc Studies in zebrafish reveal unusual cellular expression patterns of gonadotropin receptor messenger ribonucleic acids in the testis and unexpected functional differentiation of the gonadotropins
    Angel García-López
    Department of Biology, Division of Endocrinology and Metabolism, Utrecht University, Faculty of Science, Utrecht, The Netherlands
    Endocrinology 151:2349-60. 2010
    This study aimed to improve, using the zebrafish model, our understanding of the distinct roles of pituitary gonadotropins FSH and LH in regulating testis functions in teleost fish...
  10. pmc Gonadotropins regulate rat testicular tight junctions in vivo
    Mark J McCabe
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Victoria, Australia
    Endocrinology 151:2911-22. 2010
    ..are an essential component of the blood-testis barrier required for spermatogenesis; however, the role of gonadotropins in their maintenance is unknown...
  11. doi The interplay of insulin-like growth factors, gonadotropins, and endocrine disruptors in ovarian follicular development and function
    Jakub Kwintkiewicz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, California 94143 0132, USA
    Semin Reprod Med 27:43-51. 2009
    ..Some of these actions are synergistic with gonadotropins, although most are not sustainable with IGFs alone and require gonadotropin actions, thereby designating IGFs ..
  12. ncbi Minimal ovarian hyperstimulation for in vitro fertilization using sequential clomiphene citrate and gonadotropin with or without the addition of a gonadotropin-releasing hormone antagonist
    Shaun C Williams
    Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Fertil Steril 78:1068-72. 2002
    ..To compare the results of a minimal-stimulation protocol with those of a standard protocol used for IVF...
  13. pmc Comparison of the efficacy of the aromatase inhibitor letrozole and clomiphen citrate gonadotropins in controlled ovarian hyperstimulation: a prospective, simply randomized, clinical trial
    Ensieh Sh Tehrani Nejad
    Vali e Asr Reproductive Health Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
    J Assist Reprod Genet 25:187-90. 2008
    ..To study the efficacy of the aromatase inhibitor letrozole in controlled ovarian hyperstimulation (COH)...
  14. ncbi Sulfonation and sialylation of gonadotropins in women during the menstrual cycle, after menopause, and with polycystic ovarian syndrome and in men
    Leif Wide
    Department of Medical Sciences, University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 92:4410-7. 2007
    ..These charge alterations may reflect differences in the number of two negatively charged residues on the gonadotropins: sialic acid and sulfonated N-acetylgalactosamine, residues that modulate the half-life of the gonadotropins ..
  15. ncbi Differential expression and regulation of gonadotropins and their receptors in the Japanese eel, Anguilla japonica
    Shan Ru Jeng
    Department of Aquaculture, National Kaohsiung Marine University, Kaohsiung 811, Taiwan
    Gen Comp Endocrinol 154:161-73. 2007
    ..Real-time quantitative RT-PCR was used to quantify the expression of eel gonadotropins and their receptors...
  16. doi Gonadotropins induce tumor cell migration and invasion by increasing cyclooxygenases expression and prostaglandin E(2) production in human ovarian cancer cells
    Man Tat Lau
    Department of Obstetrics and Gynecology, University of British Columbia, 2H30, 4490 Oak Street, Vancouver, British Columbia, Canada V6H 3V5
    Endocrinology 151:2985-93. 2010
    b>Gonadotropins (FSH and LH) are detectable in ovarian tumor fluid, suggesting a possible role for gonadotropins in ovarian carcinogenesis and progression...
  17. doi Functional characterization of genetically labeled gonadotropes
    Shuping Wen
    Institute for Neural Signal Transduction, Center for Molecular Neurobiology, Falkenried 94, D 20253 Hamburg, Germany
    Endocrinology 149:2701-11. 2008
    ..Our mouse model will also be able to direct expression of other Cre recombination-dependent reporter genes to gonadotropes and, therefore, represents a versatile new tool in the understanding of gonadotrope biology...
  18. ncbi An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene
    K L Britt
    Prince Henry s Institute of Medical Research and Department of Anatomy, Monash University, Clayton, Victoria, Australia
    Endocrinology 141:2614-23. 2000
    ..In conclusion, the ovarian environment in ArKO mice does not allow the characteristic development of follicles that culminates in ovulation and demonstrates an in vivo requirement of estrogen for normal ovarian function in the mouse...
  19. ncbi Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid by gonadotropins in human immortalized ovarian surface epithelium and ovarian cancer cells
    Jung Hye Choi
    Department of Obstetrics and Gynecology, British Columbia Children s and Women s Hospital, Child and Family Research Institute, University of British Columbia, 2H 30, 4490 Oak St, Vancouver, British Columbia, Canada, V6H 3V5
    Endocr Relat Cancer 13:641-51. 2006
    ..In the present study, we employed real-time PCR to determine the potential regulatory effect of gonadotropins on the expression levels of GnRH I (the mammalian GnRH), GnRH II (a second form of GnRH) and their common ..
  20. pmc Synthesis and secretion of gonadotropins including structure-function correlates
    George R Bousfield
    Department of Biological Sciences, Wichita State University, Wichita, KS, USA
    Rev Endocr Metab Disord 12:289-302. 2011
    ..Finally, we discuss the therapeutic potential of understanding glycosylation function towards designing new forms of gonadotropins based on observations of physiologically relevant parameters such as age related glycosylation changes.
  21. ncbi Development of real-time RT-PCR assays for eel gonadotropins and their application to the comparison of in vivo and in vitro effects of sex steroids
    Salima Aroua
    USM 0401, UMR 5178 CNRS MNHN Université Pierre et Marie Curie, Biologie des Organismes Marins et Ecosystèmes, Département des Milieux et Peuplements Aquatiques, Museum national d histoire naturelle, 75231 Paris Cedex 05, France
    Gen Comp Endocrinol 153:333-43. 2007
    b>Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are key factors in the brain-pituitary-gonad axis and understanding their regulation remains essential for future management of eel reproduction...
  22. ncbi Development of specific enzyme-linked immunosorbent assay for determining LH and FSH levels in tilapia, using recombinant gonadotropins
    Joseph Aizen
    Department of Animal Sciences, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University, P O Box 12, Rehovot 76100, Israel
    Gen Comp Endocrinol 153:323-32. 2007
    ..Recombinant (r) gonadotropins were used to develop specific and homologous competitive ELISAs for measurements of FSH and LH in the plasma ..
  23. ncbi Ovulation induction management of PCOS
    David S Guzick
    University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Clin Obstet Gynecol 50:255-67. 2007
    ..If there is no pregnancy despite several cycles of successful ovulation induction, gonadotropin treatment should be considered, in which case in vitro fertilization is recommended as the safest and most effective strategy...
  24. doi Development of non-competitive enzyme-linked immunosorbent assays for mummichog Fundulus heteroclitus gonadotropins - examining seasonal variations in plasma FSH and LH levels in both sexes
    Akio Shimizu
    National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama 236 8648, Japan
    Gen Comp Endocrinol 178:463-9. 2012
    ..Nonetheless, they further suggest that the role of LH for various reproductive events other than the final maturation may be limited...
  25. ncbi Gonadotropins regulate N-cadherin-mediated human ovarian surface epithelial cell survival at both post-translational and transcriptional levels through a cyclic AMP/protein kinase A pathway
    Yuen Lam Pon
    Department of Zoology, University of Hong Kong, Hong Kong
    J Biol Chem 280:15438-48. 2005
    b>Gonadotropins are the major regulators of ovarian function and may be involved in the etiology of ovarian cancer...
  26. pmc The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis
    Fu Ping Zhang
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland
    Proc Natl Acad Sci U S A 100:13692-7. 2003
    ..Extrapolated to humans, it may indicate that only total abolition of testicular androgen action will result in consistent azoospermia, which is necessary for effective male contraception...
  27. ncbi Identification of follicle-stimulating hormone-selective beta-strands in the N-terminal hormone-binding exodomain of human gonadotropin receptors
    Henry F Vischer
    Department of Endocrinology, Utrecht University, The Netherlands
    Mol Endocrinol 20:1880-93. 2006
    ....
  28. pmc Expression of estrogen receptor α 36 (ESR36) in the hamster ovary throughout the estrous cycle: effects of gonadotropins
    Prabuddha Chakraborty
    Departments of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    PLoS ONE 8:e58291. 2013
    ..Esr1 and a receptor for non-genomic E signaling, in the hamster ovary during the estrous cycle and the role of gonadotropins and ovarian steroid hormones in ESR36 expression...
  29. ncbi Proteomic analysis of the mouse ovary in response to two gonadotropins, follicle-stimulating hormone and luteinizing hormone
    Manabu Satoh
    The Centre for Reproductive Medicine and Infertility, IVF Namba Clinic
    J Reprod Dev 55:316-26. 2009
    ..to our understanding of the molecular basis of functional and structural changes in the ovary in response to gonadotropins. Furthermore, the interesting ovarian proteins identified in this study may eventually serve as diagnostic ..
  30. ncbi Changes in plasma gonadotropins, inhibin and testosterone concentrations and testicular gonadotropin receptor mRNA expression during testicular active, regressive and recrudescent phase in the captive Japanese black bear (Ursus thibetanus japonicus)
    Ruriko Iibuchi
    Laboratory of Wildlife Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 57:185-96. 2010
    ..These results suggest that FSH, inhibin and testosterone have roles in testicular activity in male bears. This study provides important endocrine information for comprehending seasonal reproductivity in male Japanese black bears...
  31. doi Effect of epidermal growth factor-like peptides on pig cumulus cell expansion, oocyte maturation, and acquisition of developmental competence in vitro: comparison with gonadotropins
    Radek Prochazka
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska 89, 277 21 Libechov, Czech Republic
    Reproduction 141:425-35. 2011
    ..We conclude that EGF-like peptides do not mimic all effects of FSH on the cultured COCs; nevertheless, they yield oocytes with superior developmental competence...
  32. doi What is the optimal therapy for young males with hypogonadotropic hypogonadism?
    T S Han
    Centre for Neuroendocrinology, University College London Medical School, Royal Free Hospital, Hampstead, London NW3 2PF, UK
    Clin Endocrinol (Oxf) 72:731-7. 2010
    ..b>Gonadotropins can be self-administered subcutaneously and are not inferior to the more costly GnRH...
  33. ncbi Age-related changes in the regulation of luteinizing hormone secretion by estrogen in women
    Susanna J Park
    Department of Obstetrics, Gynecology, and Women s Health, New Jersey Medical School, 185 South Orange Avenue, MSB E 506, Newark, NJ 07103, USA
    Exp Biol Med (Maywood) 227:455-64. 2002
    ....
  34. ncbi Gonadotropins and cognition in older women
    Mark A Rodrigues
    Centre of Excellence for Alzheimer s Disease Research and Care, Hollywood Private Hospital, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia
    J Alzheimers Dis 13:267-74. 2008
    ..The findings indicate that gonadotropins can impact upon cognitive functioning in older postmenopausal women, and that luteinizing hormone and follicle ..
  35. doi Influence of the cumulus and gonadotropins on the metabolic profile of porcine cumulus-oocyte complexes during in vitro maturation
    G M Alvarez
    Institute of Research and Technology in Animal Reproduction, Area of Biochemistry, School of Veterinary Sciences, University of Buenos Aires, Buenos Aires, Argentina
    Reprod Domest Anim 47:856-64. 2012
    The aim of this work was to examine the influence of the cumulus and gonadotropins on the metabolic profile of porcine cumulus oocyte complexes (COCs) during in vitro maturation...
  36. doi Spaying-induced coat changes: the role of gonadotropins, GnRH and GnRH treatment on the hair cycle of female dogs
    Iris Margaret Reichler
    Section of Small Animal Reproduction, Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland
    Vet Dermatol 19:77-87. 2008
    ..The present study did not identify the pathomechanism of spaying-induced coat changes...
  37. ncbi Gonadotropins affect Oct-4 gene expression during mouse oocyte growth
    Manuela Monti
    Laboratorio di Biologia dello Sviluppo, Dipartimento di Biologia Animale, Universita degli Studi di Pavia, Pavia, Italy
    Mol Reprod Dev 73:685-91. 2006
    ..The results of this study show that gonadotropins induced two major increases in Oct-4 expression during folliculogenesis: (1) 48 hr after PMSG injection, in ..
  38. ncbi Gonadotropin and activin enhance maturational competence of oocytes in the zebrafish (Danio rerio)
    Yefei Pang
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Biol Reprod 66:259-65. 2002
    ....
  39. ncbi Spermatogenesis without gonadotropins: maintenance has a lower testosterone threshold than initiation
    D J Handelsman
    Department of Medicine, University of Sydney, New South Wales, Australia
    Endocrinology 140:3938-46. 1999
    ..T) alone could induce spermatogenesis and produce normally fertile spermatozoa in the absence of circulating gonadotropins. These studies used the hpg mouse, which is characterized by a congenital gonadotrophin deficiency due to a ..
  40. ncbi Pregnancies achieved by testicular sperm recovery in male hypogonadotrophic hypogonadism with persistent azoospermia
    C Akarsu
    Ankara Private IVF Centre, Ankara, Turkey
    Reprod Biomed Online 18:455-9. 2009
    ..If azoospermia persists after medical treatment, spermatozoa can be obtained surgically from testes and can be used successfully to achieve pregnancy in cases of hypogonadotrophic hypogonadism...
  41. doi Chronic effects of low lead levels on sperm quality, gonadotropins and testosterone in albino rats
    Lynda Allouche
    Department of Biology, Faculty of Sciences, University of Setif, Algeria
    Exp Toxicol Pathol 61:503-10. 2009
    The current study evaluates the impact of low or moderate levels of lead acetate (PbAc) on sperm parameters, gonadotropins (FSH, LH) and testosterone. Adult albino wistar male rats were allocated to five groups and given 0%, 0.025%, 0...
  42. doi Influence of equine growth hormone, insulin-like growth factor-I and its interaction with gonadotropins on in vitro maturation and cytoskeleton morphology in equine oocytes
    G R Pereira
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Animal 7:1493-9. 2013
    ..on the in vitro maturation (IVM) of equine oocytes, and the effects of eGH in addition to estradiol (E2), gonadotropins (FSH and LH) and fetal calf serum (FCS) on IVM...
  43. ncbi New advances in ovulation induction
    Souzan Kafy
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Curr Opin Obstet Gynecol 19:248-52. 2007
    ..To review recent advances in ovulation induction...
  44. pmc Chitosan-nanoconjugated hormone nanoparticles for sustained surge of gonadotropins and enhanced reproductive output in female fish
    Mohd Ashraf Rather
    Central Institute of Fisheries Education, Versova, Mumbai, India
    PLoS ONE 8:e57094. 2013
    ..Histology of the ovaries also attested the pronounced effect of nanoparticles on reproductive output. This is the first report on use of chitosan-conjugated nanodelivery of gonadotropic hormone in fish...
  45. pmc Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxin
    Tomoki Takeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Biol Chem 287:18440-50. 2012
    ..previous studies have revealed that maternal treatment with TCDD attenuates the fetal production of pituitary gonadotropins (luteinizing hormone (LH) and follicle-stimulating hormone) at gestational day (GD) 20, leading to the ..
  46. ncbi The role of gonadotropins in Alzheimer's disease: potential neurodegenerative mechanisms
    Anna M Barron
    Centre for Aging and Alzheimer s Disease, Edith Cowan University, Joondalup, WA, Australia
    Endocrine 29:257-69. 2006
    In addition to the classical role of gonadotropins as a modulator of sex hormone production, it is now becoming apparent that the gonadotropins may have actions within the central nervous system...
  47. doi The effect of exogenous gonadotropins on ovarian function in goats actively immunized against inhibin
    W Holtz
    Department of Animal Science, Georg August University Goettingen, Goettimngen, Germany
    Theriogenology 77:253-9. 2012
    ..acted as the key factor in determining the ovulatory response since no impact of any of the supplementary gonadotropins was noted in inhibin-immunized does...
  48. ncbi The ovary feels fine when paracrine and autocrine networks cooperate with gonadotropins in the regulation of folliculogenesis
    R Canipari
    Department of Health Sciences, University of L Aquila, L Aquila, Italy
    Curr Pharm Des 18:245-55. 2012
    ..Follicular growth and oocyte maturation are dependent primarily on pituitary-derived gonadotropins, follicle stimulating hormone (FSH) and luteinizing hormone (LH)...
  49. doi Novel pathways in gonadotropin receptor signaling and biased agonism
    Alfredo Ulloa-Aguirre
    BIOS group, INRA, UMR85, Unité Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France
    Rev Endocr Metab Disord 12:259-74. 2011
    b>Gonadotropins play a central role in the control of male and female reproduction. Selective agonists and antagonists of gonadotropin receptors would be of great interest for the treatment of infertility or as non steroidal contraceptive...
  50. ncbi ICSI using testicular sperm in male hypogonadotrophic hypogonadism unresponsive to gonadotrophin therapy
    I Fahmy
    The Egyptian IVF ET Center, Maadi, Cairo 11431
    Hum Reprod 19:1558-61. 2004
    ..The aim of this study was to assess the use of testicular sperm for ICSI in azoospermic men with hypogonadotrophic hypogonadism unresponsive to gonadotrophin therapy...
  51. ncbi Clinical evidence that hyperinsulinaemia independent of gonadotropins stimulates ovarian growth
    Carla Musso
    Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1770, USA
    Clin Endocrinol (Oxf) 63:73-8. 2005
    ..Ovarian enlargement is a constant feature of syndromes of extreme insulin resistance. The objective of this study is to show the role of insulin on ovarian growth in the presence of low gonadotropin levels...
  52. ncbi Sex differences and individual differences in cognitive performance and their relationship to endogenous gonadal hormones and gonadotropins
    Rozmin Halari
    Department of Psychology, City University, London, England
    Behav Neurosci 119:104-17. 2005
    ..and cognitive performance, suggesting that there are few, if any, consistent, substantial relationships between endogenous, nonfluctuating levels of gonadal hormones or gonadotropins and these cognitive abilities in men or women.
  53. ncbi Proteolytic activity of the 26S proteasome is required for the meiotic resumption, germinal vesicle breakdown, and cumulus expansion of porcine cumulus-oocyte complexes matured in vitro
    Young Joo Yi
    Division of Animal Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Biol Reprod 78:115-26. 2008
    ..We conclude that proteasomal proteolysis has multiple functions in the progression of oocyte meiosis beyond GV and metaphase I stage, polar body extrusion, and cumulus expansion...
  54. doi Serum anti-Müllerian hormone (AMH) levels are differentially modulated by both serum gonadotropins and not only by serum follicle stimulating hormone (FSH) levels
    Dimitrios Panidis
    Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Greece
    Med Hypotheses 77:649-53. 2011
    ..knowledge, this opinion article aims to show that serum AMH levels are differentially modulated by both serum gonadotropins, depending on the degree of ovarian reserve...
  55. doi Does stimulation with human gonadotropins and gonadotropin-releasing hormone agonist enhance and accelerate the developmental capacity of oocytes in human ovarian tissue xenografted into severe combined immunodeficient mice?
    Laura Lotz
    Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich Alexander Universität Erlangen Nürnberg FAU, Erlangen, Germany
    Fertil Steril 101:1477-84. 2014
    ..To assess the capacity of human frozen-thawed ovarian follicles matured in xenografts to form metaphase II (MII) oocytes after xenotransplantation and exogenous stimulation...
  56. ncbi Effects of gonadotropin on ovarian intrafollicular processes during the development of oocyte maturational competence in a teleost, the Atlantic croaker: evidence for two distinct stages of gonadotropin control of final oocyte maturation
    R Patino
    University of Texas, Austin Marine Science Institute, Port Aransas 78373 1267
    Biol Reprod 43:818-27. 1990
    ..The priming stage may involve mechanisms requiring RNA as well as protein synthesis...
  57. ncbi Purification of mummichog (Fundulus heteroclitus) gonadotropins and their subunits, using an immunochemical assay with antisera raised against synthetic peptides
    Akio Shimizu
    National Research Institute of Fisheries Science, Fukuura 2 12 4, Kanazawa, Yokohama 236 8648, Japan
    Gen Comp Endocrinol 125:79-91. 2002
    To detect mummichog gonadotropins (GtHs) and their subunits immunochemically, fragment peptides with amino acid sequences corresponding to cDNA data were synthesized, and antisera were raised against them...
  58. ncbi Present and future of recombinant gonadotropins in reproductive medicine
    Vincenzo De Leo
    Department of Obstetrics and Gynecology, Policlinico Le Scotte, 53100 Siena, Italy
    Curr Pharm Biotechnol 13:379-91. 2012
    ..Currently, gonadotropins are the most important tools to proceed with ovarian stimulation for all purposes, including ART and ..
  59. ncbi Molecular characterization of two sea bass gonadotropin receptors: cDNA cloning, expression analysis, and functional activity
    Ana Rocha
    Department of Fish Physiology and Biotechnology, Instituto de Acuicultura de Torre la Sal, Consejo Superior de Investigaciones Cientificas, 12595 Torre la Sal, Ribera de Cabanes, Castellon, Spain
    Mol Cell Endocrinol 272:63-76. 2007
    ..Nevertheless, specific stimulation of the sbsLHR was observed when recombinant sea bass gonadotropins were used...
  60. ncbi Effect of gonadotropins during in vitro maturation of feline oocytes on oocyte-cumulus cells functional coupling and intracellular concentration of glutathione
    Gaia C Luvoni
    Department of Veterinary Clinical Sciences, Obstetrics and Gynaecology, University of Milan, Italy
    Anim Reprod Sci 96:66-78. 2006
    ..The aim of this study was to investigate the effect of the presence of gonadotropins during IVM, on meiotic progression in relation to the status of gap junction mediated communications between ..
  61. ncbi A preliminary study of serum concentrations of soluble epidermal growth factor receptor (sErbB1), gonadotropins, and steroid hormones in healthy men and women
    A T Baron
    Tumor Biology Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 10:1175-85. 2001
    ..Furthermore, these data demonstrate that gender, age, menstrual cycle phase, menopausal status, and exogenous hormone use must be considered when using serum p110 sErbB1 concentrations as cancer biomarkers...
  62. ncbi Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial
    Tsung Hsien Lee
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
    Fertil Steril 90:113-20. 2008
    ..To evaluate the effectiveness of a GnRH antagonist in preventing premature LH surge under a letrozole and gonadotropin protocol...
  63. ncbi Gonadotropins: a cohesive gender-based etiology of Alzheimer disease
    Kate M Webber
    Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Mol Cell Endocrinol 260:271-5. 2007
    ..In this review, we examine how the gonadotropins may play a central and determining role in modulating the susceptibility to, and progression of, Alzheimer ..
  64. ncbi Molecular cloning and induction of bovine prostaglandin E synthase by gonadotropins in ovarian follicles prior to ovulation in vivo
    F Filion
    Centre de Recherche en Reproduction Animale and the Département de Biomédecine Vétérinaire, Faculte de Medecine Veterinaire, Universite de Montreal, C P 5000, Saint Hyacinthe, Quebec J2S 7C6, Canada
    J Biol Chem 276:34323-30. 2001
    ..the objectives of this study were to clone bovine PGE synthase (PGES) and to characterize its regulation by gonadotropins in preovulatory follicles in vivo...
  65. doi Bilateral undescended testes classified according to preoperative and postoperative status of gonadotropins and inhibin B in relation to testicular histopathology at bilateral orchiopexy in infant boys
    Jorgen Thorup
    Department of Pediatric Surgery, Rigshospitalet, Copenhagen, Denmark
    J Urol 188:1436-42. 2012
    ..We evaluated whether blood samples of gonadotropins and inhibin B as well as histopathology could be used to classify undescended testes.
  66. ncbi Effects of thyroid hormones on bovine granulosa and thecal cell function in vitro: dependence on insulin and gonadotropins
    L J Spicer
    Department of Animal Science, Oklahoma State University, Stillwater 74078, USA
    J Dairy Sci 84:1069-76. 2001
    ..These results support the hypothesis that thyroid hormones may have direct stimulatory effects on ovarian function in cattle, acting at the level of granulosa and thecal cells...
  67. ncbi Contemporary issues in primary amenorrhea
    Lorna S Timmreck
    Division of Reproductive Endocrinology and Infertility, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, KS 322, Boston, MA 02215, USA
    Obstet Gynecol Clin North Am 30:287-302. 2003
    ..However, the reported deaths of patients with Turner's syndrome who become pregnant by donor oocyte should remind us to proceed cautiously as new reproductive avenues are opened for these patients...
  68. ncbi Tilapia follicle-stimulating hormone (FSH): immunochemistry, stimulation by gonadotropin-releasing hormone, and effect of biologically active recombinant FSH on steroid secretion
    Joseph Aizen
    Department of Animal Sciences, Faculty of Agricultural, Food and Environmental Quality Sciences, Hebrew University, Rehovot 76100, Israel
    Biol Reprod 76:692-700. 2007
    ..Moreover, FSH is under the control of hypothalamic decapeptide GnRH, an effect that was abolished through the use of specific bioneutralizing antisera, anti-rtFSH beta. It also reduced basal secretion of 11-KT...
  69. doi The role of gonadotropins in the follicular phase
    Ioannis E Messinis
    Department of Obstetrics and Gynecology, University of Thessalia Medical School, Larissa, Greece
    Ann N Y Acad Sci 1205:5-11. 2010
    Folliculogenesis in humans is a lengthy process that involves several regulators. Pituitary gonadotropins play crucial roles in the late stages, particularly in the last 15 days of follicle maturation...
  70. ncbi Ovarian response to gonadotropins after laparoscopic salpingectomy or the division of fallopian tubes for hydrosalpinges
    Tarek A Gelbaya
    Department of Reproductive Medicine, Saint Mary s Hospital, Manchester, United Kingdom
    Fertil Steril 85:1464-8. 2006
    To compare the effect of prophylactic laparoscopic salpingectomy versus division of the fallopian tubes on ovarian response to gonadotropins in women undergoing IVF.
  71. ncbi Gonadotropins, prolactin, inhibin A, inhibin B, and activin A in human fetal serum from midpregnancy and term pregnancy
    F Debieve
    Department of Obstetrics and Gynecological Endocrinology, Universite Catholique de Louvain, Brussels, Belgium
    J Clin Endocrinol Metab 85:270-4. 2000
    ..We speculate that inhibin A could be a method to detect maternal blood contamination in cord venipuncture...
  72. ncbi Gonadotropins, their receptors, and the regulation of testicular functions in fish
    R W Schulz
    Research Group Endocrinology, Department of Developmental Biology, Faculty of Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
    Comp Biochem Physiol B Biochem Mol Biol 129:407-17. 2001
    The pituitary gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) regulate steroidogenesis and spermatogenesis by activating receptors expressed by Leydig cells (LH receptor) and Sertoli cells (FSH receptor), ..
  73. ncbi Resistance to growth hormone releasing hormone and gonadotropins in Albright's hereditary osteodystrophy
    Giovanna Mantovani
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Milan, Italy
    J Pediatr Endocrinol Metab 19:663-70. 2006
    ..PHP-Ia display variable degrees of resistance to parathyroid hormone (PTH), thyroid stimulating hormone (TSH), gonadotropins and growth hormone (GH) releasing hormone (GHRH)...
  74. doi Use of gonadotropins for initiation of singleton gestations in non-assisted reproductive technology cycles
    Michael P Diamond
    Wayne State University School of Medicine, Detroit, Michigan, USA
    Fertil Steril 97:810-2. 2012
    b>Gonadotropins are a valuable part of the armamentarium available to assist couples in achieving a live birth...
  75. doi Molecular characterization of marbled eel (Anguilla marmorata) gonadotropin subunits and their mRNA expression profiles during artificially induced gonadal development
    Hai Huang
    State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and the Guangdong Province Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat Sen University, Guangzhou, China
    Gen Comp Endocrinol 162:192-202. 2009
    ....
  76. ncbi What is the underlying cause of aneuploidy associated with increasing maternal age? Is it associated with elevated levels of gonadotropins?
    Polat Dursun
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara 06100, Turkey
    Med Hypotheses 66:143-7. 2006
    ..Such high level gonadotropins are also seen physiologically in the adolescent period...
  77. ncbi [Gonadotropins and ovarian cancer]
    Ewa Nowak-Markwitz
    Klinika Onkologii Ginekologicznej, AM im Karola Marcinkowskiego w Poznaniu
    Ginekol Pol 76:153-62. 2005
    The ovary is a tissue, which is sensitive to gonadotropins. Gonadotropins receptors are present in the epithelium and stroma of the ovary...
  78. doi Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial
    Stefano Palomba
    Department of Obstetrics and Gynecology, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Fertil Steril 96:1128-33. 2011
    To evaluate the effects of metformin on the ovarian response to gonadotropins given for in vitro fertilization (IVF) programs in patients with polycystic ovary syndrome (PCOS) and reduced ovarian reserve.
  79. doi Plasma kisspeptin levels are elevated in cord blood and present sexual dimorphism in the adult population: relation with leptin, gonadotropins and anthropometrical data
    Jimena Pita
    Laboratory of Endocrinology, Institute of Biomedical Research Fundación Jiménez Díaz, Universidad Autonoma de Madrid, Madrid, Spain
    Peptides 32:983-8. 2011
    ..To test our hypothesis, we have analyzed plasma kisspeptin levels and their possible relationship with gonadotropins and leptin in a cohort composed of newborns (n = 86) and adults (n = 55)...
  80. pmc Suppression of gonadotropins and estradiol in premenopausal women by oral administration of the nonpeptide gonadotropin-releasing hormone antagonist elagolix
    R Scott Struthers
    Neurocrine Biosciences Inc, 12780 El Camino Real, San Diego, California 92130, USA
    J Clin Endocrinol Metab 94:545-51. 2009
    ..Parenteral administration of peptide GnRH analogs is widely employed for treatment of endometriosis and fibroids and in assisted-reproductive therapy protocols. Elagolix is a novel, orally available nonpeptide GnRH antagonist...
  81. doi Peripheral concentrations of inhibin A, ovarian steroids, and gonadotropins associated with follicular development throughout the estrous cycle of the sow
    Michiko Noguchi
    Laboratory of Veterinary Internal Medicine, Azabu University, Sagamihara, Kanagawa 229 8501, Japan
    Reproduction 139:153-61. 2010
    We investigated changes in peripheral concentrations of inhibin A, total inhibin, steroids, and gonadotropins throughout the intact estrous cycle of the sow in relation to ovarian changes determined by daily transrectal ultrasonography...
  82. doi Falling FSH levels predict poor IVF pregnancy rates in patients whom the gonadotropins are withheld
    Munire Erman Akar
    Department of Obstetrics and Gynecology, Dumlupinar Bulvari, Akdeniz University, School of Medicine, Kadin Hastaliklari ve Dogum A D, Antalya, Turkey
    Arch Gynecol Obstet 280:761-5. 2009
    To determine whether monitoring follicle stimulating hormone (FSH) levels in over-responding patients whom the gonadotropins were withheld would predict pregnancy outcome.
  83. pmc Combined transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in men
    Vahid Mahabadi
    Department of Medicine, Division of Endocrinology, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
    J Clin Endocrinol Metab 94:2313-20. 2009
    ..Nestorone (NES), a progestin without estrogenic or androgenic activity, when combined with T may be an excellent candidate for male contraception...
  84. ncbi Gonadal defects and hormonal alterations in transgenic mice expressing a single chain human chorionic gonadotropin-lutropin receptor complex
    Thomas P Meehan
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    J Mol Endocrinol 34:489-503. 2005
    ..Taken together, these data indicate that the single chain YHR is functional in vivo and demonstrate that YHR(+) mice provide a novel system to further understand the reproductive consequences of aberrant LHR activation...
  85. doi Disruption of lipid rafts induces gonadotropin release in ovine pituitary and LbetaT2 gonadotroph cells
    E Robin
    UMR Physiologie de la Reproduction et des Comportements, INRA CNRS Université Tours Haras Nationaux, 37380 Nouzilly, France
    Biol Reprod 79:17-25. 2008
    ..underlying LH and FSH secretion, we have addressed the contribution of lipid rafts to the secretion of gonadotropins. We used methyl-beta-cyclodextrin (MbetaCD), a cholesterol-sequestering agent, on an LbetaT2 murine ..
  86. ncbi An activated human follicle-stimulating hormone (FSH) receptor stimulates FSH-like activity in gonadotropin-deficient transgenic mice
    Miriam Haywood
    Andrology Laboratory, ANZAC Research Institute, Sydney, New South Wales 2139, Australia
    Mol Endocrinol 16:2582-91. 2002
    ..This novel transgenic paradigm provides a unique approach to investigate the in vivo actions of mutated activating gonadotropin receptors...
  87. ncbi Effect of 2-deoxy-D-glucose on gonadotropins, prolactin and serum glucose concentrations in the mare
    Christina J McManus
    Department of Veterinary Science, Maxwell Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546 0099, USA
    Anim Reprod Sci 71:217-28. 2002
    ..This lack of response to glucoprivation may reflect species differences in the response to glucoprivation or may be due to metabolic responses to the inhibition of glucose availability...
  88. pmc Peritoneal adhesion and angiogenesis in ovarian carcinoma are inversely regulated by hyaluronan: the role of gonadotropins
    Yael Chagit Tzuman
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
    Neoplasia 12:51-60. 2010
    ..We postulated that menopause could augment ovarian cancer progression through the effects of gonadotropins on multifocal seeding to the mesothelial layer lining the peritoneum...
  89. doi Effects of exogenous testosterone supplementation in gonadotrophin stimulated cycles
    Christopher S Sipe
    Fertility Centers of Illinois, Chicago, IL 60610, USA
    Hum Reprod 25:690-6. 2010
    ..Our aim was to determine the effects of exogenous testosterone supplementation in older women on ovarian folliculogenesis and steroidogenesis...
  90. ncbi Serum concentrations of gonadotropins and steroid hormones of Neophocaena phocaenoides asiaeorientalis in middle and lower regions of the Yangtze River
    Yu Jiang Hao
    Institute of Hydrobiology, The Chinese Academy of Sciences, No 7, South Road of East Lake, Wuchang District, Wuhan 430072, China
    Theriogenology 67:673-80. 2007
    ..To our knowledge, this is the first study of endocrine-related maturity and seasonal breeding characteristics of the Yangtze finless porpoise...
  91. doi The expanding role of recombinant gonadotropins in assisted reproduction
    T E Adams
    Department of Animal Science, University of California, Davis, CA, USA
    Reprod Domest Anim 43:186-92. 2008
    Using recombinant gonadotropins for assisted reproduction of domestic species is still in its infancy...
  92. doi Effects of puberty and gonadotropins on the molecular events controlling meiotic resumption of mouse oocytes
    Dong Han
    Laboratory for Animal Reproduction and Embryology, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai an City 271018, Shandong Province, People s Republic of China
    Reproduction 139:959-69. 2010
    ..meiotic progression and allowing more time for cytoplasmic maturation, the mechanisms by which puberty and gonadotropins regulate meiotic progression require additional detailed studies...
  93. ncbi Correlation between the Aging Males' Symptoms Scale and sex steroids, gonadotropins, dehydroepiandrosterone sulfate, and growth hormone levels in ambulatory men
    Yoshiji Miwa
    Department of Urology, University of Fukui, Fukui, Japan
    J Sex Med 3:723-6. 2006
    ..In addition to testosterone, the levels of other hormones also decrease with age; therefore, multihormone alterations may influence PADAM-related symptoms...
  94. doi Dynamics of circulating concentrations of gonadotropins and ovarian hormones throughout the menstrual cycle in the bonnet monkey: role of inhibin A in the regulation of follicle-stimulating hormone secretion
    P S Suresh
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
    Am J Primatol 71:817-24. 2009
    ..The results taken together suggest a tight coupling between LH and INH A secretion and that INH A is largely responsible for maintenance of low FSH concentration seen during the luteal phase...
  95. ncbi A prospective randomized trial comparing anastrozole and clomiphene citrate in an ovulation induction protocol using gonadotropins
    Christopher S Sipe
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1080, USA
    Fertil Steril 86:1676-81. 2006
    To compare the ovarian and endometrial effects of anastrozole and clomiphene when used with gonadotropins in a combination protocol.
  96. ncbi Predictors of ovarian response: progress towards individualized treatment in ovulation induction and ovarian stimulation
    B C J M Fauser
    Department of Reproductive Medicine and Gynecology, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Hum Reprod Update 14:1-14. 2008
    ..In this review, the methodology behind predictive factors and prediction models and their potential clinical applicability across ovulation induction and ovarian stimulation are explored...
  97. doi Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study
    Amr A Azim
    Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York, USA
    J Clin Oncol 26:2630-5. 2008
    ....
  98. ncbi A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report
    S K Goswami
    Institute of Reproductive Medicine, Salt Lake, Kolkata 700091, India
    Hum Reprod 19:2031-5. 2004
    ..Use of letrozole, a selective inhibitor of aromatase, reduces the gonadotrophin dose required to induce follicular maturation. We evaluated whether incorporation of letrozole could be an effective low-cost IVF protocol for poor responders...
  99. doi Expression and gonadotropin regulation of membrane progestin receptor alpha in Atlantic croaker (Micropogonias undulatus) gonads: role in gamete maturation
    Christopher Tubbs
    The University of Texas at Austin, Marine Science Institute, Port Aransas, 78373 TX, USA
    Gen Comp Endocrinol 165:144-54. 2010
    ..Taken together, these data strongly support the hypothesis that mPRalpha mediates progestin induction of oocyte maturation and upregulation of sperm motility in teleosts...
  100. ncbi Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition
    Richard L Bowen
    Voyager Pharmaceutical Corporation, Raleigh, NC 27615, USA
    J Biol Chem 279:20539-45. 2004
    ..Because sex steroids and gonadotropins are both part of the HPG feedback loop, any loss in sex steroids results in a proportionate increase in ..
  101. ncbi Reversal of idiopathic hypogonadotropic hypogonadism
    Taneli Raivio
    Harvard Center for Reproductive Endocrine Sciences and the Reproductive Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
    N Engl J Med 357:863-73. 2007
    ..Idiopathic hypogonadotropic hypogonadism was previously thought to require lifelong therapy. We describe 15 men in whom reversal of idiopathic hypogonadotropic hypogonadism was sustained after discontinuation of hormonal therapy...

Research Grants70

  1. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..abstract_text> ..
  2. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..The long-term objectives of this research are to fully understand the cellular mechanisms of action of gonadotropins and the regulation of steroidogenesis...
  3. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..Following leptin treatment, a gradual increase in gonadotropins and estradiol levels, enlargement of the gonads and pubertal development were observed...
  4. Transcriptional control of pituitary gonadotropin genes
    Varykina G Thackray; Fiscal Year: 2013
    ..Funding of this proposal will also allow the PI, as an Early-Stage Investigator, to establish a fully-independent research program in the field of reproductive endocrinology. ..
  5. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..and 7) the negative correlation between serum sex steroids, but positive correlation between serum gonadotropins, in women and men with AD...
  6. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ..disrupts follicular development, ovarian steroid production, or renders ovarian follicles less responsive to gonadotropins. Specific Aim 2 determines if 1,25-(OH)2D3 deficiency disrupts hypothalamic-pituitary axis function...
  7. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..The proposed research will investigate the cellular mechanisms that underlie this gene-environment interaction that affects a behavior associated with many mental disorders. ..
  8. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2013
    ..We hope to understand how mutations in two genes (CHD7 and NELF) disrupt puberty and cause infertility in humans. These human studies will be complemented by experiments in relevant cell types and an animal model. ..
  9. MOUSE MODEL FOR DISEASES OF PROTEIN MISFOLDING
    P Michael Conn; Fiscal Year: 2012
    ..A convenient laboratory model for these diseases is needed if the use of pharmacoperones is to translate to human well-being, since US law requires animal testing prior to normal human volunteers. ..
  10. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ....
  11. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..An understanding of the fetal mechanisms associated with sex differences in MOD will have etiologic imolications and imoortance for the development of sex-specific treatments and prevention of MOD. ..
  12. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    ....
  13. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..It is also expected that kisspeptin-induced Ca2+ mobilization will increase at puberty and that these changes will account for the pubertal increase in GnRH secretion. ..
  14. Molecular Analysis of GnRH Action
    Mark S Roberson; Fiscal Year: 2012
    ..between the brain, pituitary gland and the gonad through the actions of gonadotropin releasing hormone (GnRH), gonadotropins and gonadal hormones...
  15. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    ..The proposed research will generate proof-of-principle data on antagonists to a previously unexplored drug target that is highly expressed in endometriosis and appears to be central to the pathophysiology of this debilitating disease. ..
  16. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    ..Therefore, the failure to accrue peak bone mass during the adolescent years represents a missed opportunity to optimize bone mass during one's life. ..
  17. CONTROL OF GONADOTROPIN SECRETION DURING LACTATION
    Kevin L Grove; Fiscal Year: 2013
    ..These studies will identify new pathways that regulate kisspeptin neurons that in turn control GnRH neurons and could lead to new treatments for restoring fertility or for new contraceptive agents that inhibit fertility. ..
  18. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010
    ..Upon stimulation by gonadotropins, granulosa cells rapidly divide and the follicle grows until proliferation is terminated by a surge in ..
  19. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..This proposal thus addresses important questions about how leptin can affect reproductive competence at the level of the pituitary. ..
  20. WNT and gonadotropin mediated regulation of ovarian steroidogenesis
    JENNIFER HERNANDEZ GIFFORD; Fiscal Year: 2010
    ....
  21. Novel functions of RGS3
    Nickolai O Dulin; Fiscal Year: 2012
    ..Therefore, defining the molecular mechanisms of T cell activation and differentiation may lead to a better understanding the pathogenesis of these diseases. ..
  22. Integration of PR and FoxO Signaling in Pituitary Gonadotropes
    Varykina G Thackray; Fiscal Year: 2010
    ....
  23. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..e., pre-hCG) will be directly exposed to LIF to determine a direct effect of this cytokine on promoting C-OE, reinitiation of meiosis, fertilization, and embryonic development. ..
  24. The Kiss1 system in the neuroendocrine control of reproduction
    VICTOR MANUEL NAVARRO; Fiscal Year: 2013
    ..This additional training will aid in my development of a competitive research program and contribute to my establishment as an independent investigator. ..
  25. Oocyte-derived R-spondin2 as a Follicle Stimulating Hormone
    AARON JW HSUEH; Fiscal Year: 2013
    ..This will be followed by the derivation of healthy pups as the basis for future clinical application using R-spondin2 to treat infertile patients with low FSH responses. ..
  26. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2013
    ..This multifaceted approach should yield a comprehensive understanding of the program of GnRH neuronal migration and cell fate in vivo and in vitro and provide insight into the genetics of hypogonadotropic hypogonadism. ..
  27. CELLULAR AND MOLECULAR BASES FOR RHYTHMIC GNRH RELEASE
    Suzanne M Moenter; Fiscal Year: 2013
    ..We also have preliminary data supporting the equally interesting hypothesis that GnRH feeds back to inhibit KNDy neuronal networks. ..
  28. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2011
    ..in a pulsatile pattern from a population of ~800 neurons, scattered throughout the hypothalamus, to regulate gonadotropins in the pituitary...
  29. Variations in Hormones During Menopause: Effects on Cognitive and Brain Aging
    Heather A Bimonte-Nelson; Fiscal Year: 2013
    ..VCD-treated rats undergo ovarian failure;follicles and estrogens deplete, androgens become unopposed, and gonadotropins increase, a profile resembling transitionally menopausal women...
  30. Embryonic regulation of GnRH neuron migration and function
    David J Kozlowski; Fiscal Year: 2012
    ..A further understanding of the mechanisms guiding GnRH neuron migration is essential to determine the etiology of birth defects and predict clinical outcomes regarding reproductive maturation and fertility in humans. ..
  31. REGULATION OF OVARIAN FUNCTION BY GONADOTROPIN
    JAIRAM K M MENON; Fiscal Year: 2013
    ..The studies proposed here address novel questions that are central to reproductive endocrinology and the results might provide new insights into novel approaches for the treatment of infertility. ..
  32. Neural basis of leptin action on reproduction
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..Following leptin treatment, a gradual increase in gonadotropins and estradiol levels, enlargement of the gonads and pubertal development were observed...
  33. Hormonal and Paracrine Regulation of Spermatogenesis
    Barry R Zirkin; Fiscal Year: 2010
    ..These biosensors will be designed to measure oxidized nucleosides, 8-oxodeoxyadenosine and 8-oxodeoxyguanosine, in the DNA of sperm from infertile men. ..
  34. DEVELOPMENT OF MAMMALIAN OOCYTE-GRANULOSA CELL COMPLEX
    John J Eppig; Fiscal Year: 2012
    ..The regulation of follicular development is complex, involving gonadotropins, steroid hormones, and other paracrine and autocrine growth factors that are crucially important for ..
  35. Insulin and IGF-1 regulation of the GnR H neuron
    Sara A DiVall; Fiscal Year: 2012
    ..These studies will provide insight into how the brain's control of reproduction is affected by the nutrition dependent hormones insulin and insulin-like growth factor-1. ..
  36. Physiological Mechanisms Underlying Heightened Responsiveness of Gonadotropes to
    Colin M Clay; Fiscal Year: 2013
    ....
  37. Ovarian hormone suppression and regulation of adipogenesis in women
    Wendy M Kohrt; Fiscal Year: 2012
    ..Thus, identifying strategies that effectively prevent an increase in adipogenesis during ovarian hormone withdrawal would be of high clinical importance. ..
  38. Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2010
    ..The results should provide new insight into the integrative biological mechanisms by which sex hormone deficiency modulates the age-related reduction in large artery compliance in women as they transition through the menopause. ..
  39. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin M Matzuk; Fiscal Year: 2010
    ..Both gonadotropins (FSH and LH) are also involved in the tumorigenesis process...
  40. Exploring the Role of the Prokineticin System in Human Reproduction
    ANA PAULA DE ABREU E SILVA METZGER; Fiscal Year: 2013
    ....
  41. Protease regulation of ovarian recrudescence
    KELLY ANSLEY YOUNG; Fiscal Year: 2013
    ..where seasonal changes in day length can either inhibit or stimulate hypothalamic/ pituitary secretion of GnRH/gonadotropins, leading to atrophy or resumption of ovarian function...
  42. Vervet Monkey: Modeling Effects of Diet-Induced Obesity on Reproduction
    Alex Joel Polotsky; Fiscal Year: 2011
    ..central reproductive drive is present in regularly cycling obese women as demonstrated by diminished levels of gonadotropins and sex steroids. This relative hypogonadotropic hypogonadism of obesity is only partially understood...
  43. Melatonin in Menopausal Depression
    Barbara L Parry; Fiscal Year: 2012
    ..It also will confirm and extend our understanding of chronobiological abnormalities in depressed women as the basis for developing innovative treatments. ..
  44. Regulation of Leydig cell function by small noncoding RNAs
    Wei Yan; Fiscal Year: 2013
    ..persistently elevated levels of T, decreased levels of estradiol (E2), and slightly increased levels of both gonadotropins (FSH and LH)...
  45. Bisphenol-A and Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2013
    ..controlling postnatal neuroendocrine feedback controls of GnRH/LH secretion and ovarian sensitivity to gonadotropins. Further, prenatal exposure to BPA will exacerbate postnatal reproductive susceptibility to steroid exposure ..
  46. The interaction between sleep and reproductive hormone secretion during puberty
    NATALIE DARA SHAW; Fiscal Year: 2013
    ....
  47. Neural substrates for matching hearing to utterance
    Darcy B Kelley; Fiscal Year: 2012
    ..If so, understanding auditory/vocal matching in Xenopus could provide a set of candidate neural mechanisms whose prevalence and utility can then be investigated more widely. ..
  48. Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOS
    Christopher R McCartney; Fiscal Year: 2012
    ..abstract_text> ..
  49. RCT of GnRH-a for ovarian protection during CYC therapy for rheumatic disease
    WILLIAM J MC CUNE; Fiscal Year: 2012
    ..Prevention of premature ovarian failure is important not only to preserve fertility, but also to reduce risk of other health problems associated with early menopause, such as cardiovascular disease, osteoporosis, and overall mortality. ..
  50. Gonadotropins in a female model of age-induced hypertension
    KATHRYN L SANDBERG; Fiscal Year: 2012
    ..The clinical significance of this research is the insight it will provide into the mechanisms underlying the marked rise in the prevalence of hypertension in women as they age and after their transition into menopause. ..
  51. Central actions of estrogens: Effects of GnRH neurons
    Suzanne M Moenter; Fiscal Year: 2013
    ..Integration of the data resulting from the study of an excitatory and an inhibitory afferet network into existing knowledge will increase our understanding of the central neuronal control of ovulation by estradiol. ..
  52. Derivation of Mature Oocytes from Human Primordial Follicles
    AARON JW HSUEH; Fiscal Year: 2010
    ..At the early antral stage, select follicles respond to gonadotropins and one preovulatory follicle release the mature oocyte for fertilization...
  53. STRESS AND REPRODUCTIVE HORMONES IN DEPRESSION
    Jon Kar Zubieta; Fiscal Year: 2012
    ..This project will evaluate whether women with depression show low estrogen levels and if the changes in estrogen are accompanied by changes in serotonin binding in the brains of women with major depression ..
  54. Novel Receptor-Targeting Theranostic Peptides for Prostate Cancer
    Yubin Miao; Fiscal Year: 2013
    ....
  55. Circadian Regulation of Gonadotropin-Releasing Hormone
    Patrick E Chappell; Fiscal Year: 2010
    ....
  56. Sexual differentiation and development of reproductive neural circuits
    Sheila J Semaan; Fiscal Year: 2011
    ..abstract_text> ..
  57. A Novel Testicular Germ Cell Maturation Model for Fertility Preservation in Pre-p
    Kirk C Lo; Fiscal Year: 2012
    ..The initiation of puberty involves a series of complex endocrine events culminating in an increase in gonadotropins and the subsequent induction of spermatogenesis...
  58. GnRH-Regulated Transcriptome in the Gonadotrope
    Djurdjica Coss; Fiscal Year: 2010
    ..overlap of these data sets will identify the genes whose transcription may be regulated similarly to gonadotropins. In the second aim, using a two-hybrid screen of a cDNA library from gonadotrope-derived cells, we will ..
  59. Excess androgen production in overweight pubertal girls--precursor to PCOS
    CHRISTINE MICHELE BURT SOLORZANO; Fiscal Year: 2013
    ..It may identify targets for therapeutic strategies to treat or prevent androgen excess during puberty - a critical stage for the development of PCOS. ..
  60. Determining the role of RFRP-3 in stress-related female infertility
    MOLLY JOANNE DICKENS; Fiscal Year: 2013
    ..Ultimately, the goal of this research is to help define a mode of dysregulation underlying stress-induced infertility in women. ..
  61. Regulation of Follistatin Expression by Activin
    Louise M Bilezikjian; Fiscal Year: 2013
    ..to locally regulate gonadotrope function and promote the differential expression and secretion of the two gonadotropins, FSH and LH...
  62. Identification of target genes for Lhx3 in gonadotropes
    Richard A Maurer; Fiscal Year: 2012
    ..in mice or humans that inactivate LHX3 have been found to drastically decrease production and secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH)...
  63. EXPRESSION OF OVARIAN INHIBIN AND ACTIVIN GENES
    Kelly Mayo; Fiscal Year: 1993
    ..Four protein hormones that modulate the synthesis and secretion of the pituitary gonadotropins have been described...
  64. GALANIN REGULATION OF PITUITARY REPRODUCTIVE HORMONES
    ANGELA BAUER DANTOIN; Fiscal Year: 1999
    ..abstract_text> ..
  65. PRETRANSLATIONAL REGULATION OF FSH AND LH
    Margaret Wierman; Fiscal Year: 1993
    ..Additionally, they will impact on the design of future fertility and contraceptive agents and potential therapeutic interventions for reproductive disorders and hormone responsive malignancies...
  66. ABNORMALITIES IN CALVES FROM EMBRYO TRANSFER
    George Seidel; Fiscal Year: 1980
    Human infertility is often treated with exogenous gonadotropins or drugs to stimulate endogenous gonadotropin secretion. Despite this fact, only anecdotal information is available on normalcy of resulting pregnancies and children...
  67. Long-term Follow-Up of Infertility Patients: A Pilot Study
    Francine Grodstein; Fiscal Year: 2010
    ..Thus, we propose to conduct a pilot study exploring the possibility of initiating research on infertility treatment in relation to long-term health within participants of the ongoing Nurses'Health Study II. ..
  68. MECHANISMS GOVERNING ONSET OF OVARIAN FUNCTION
    Kathleen Ryan; Fiscal Year: 1990
    ..Thus an added tool is available to allow the distinction of somatic changes from pubertal changes, and the separation of photoperiod specific changes from puberty specific ones - a truly exciting prospect...
  69. SAGE Analysis of Murine Oocyte Maturation
    CHARLOTTE FARIN; Fiscal Year: 2004
    ..adversely affect embryo development following in vitro fertilization and are influenced by exposure to gonadotropins during oocyte maturation...
  70. Regulation of Immediate Early Genes by GnRH in the Gonadotrope
    Djurdjica Coss; Fiscal Year: 2009
    ..Thus, understanding the molecular mechanisms governing gonadotrope gene expression will lead to insight into the physiology and pathophysiology of the reproductive system. ..