inhibins

Summary

Summary: Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively

Top Publications

  1. ncbi Changes in expression of bone morphogenetic proteins (BMPs), their receptors and inhibin co-receptor betaglycan during bovine antral follicle development: inhibin can antagonize the suppressive effect of BMPs on thecal androgen production
    Claire Glister
    School of Biological Sciences, Hopkins Building, University of Reading, Whiteknights, Reading RG6 6UB, UK
    Reproduction 140:699-712. 2010
  2. ncbi A systematic review of tests predicting ovarian reserve and IVF outcome
    F J Broekmans
    Department of Reproductive Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands
    Hum Reprod Update 12:685-718. 2006
  3. pmc Impact of cancer therapies on ovarian reserve
    Clarisa R Gracia
    Department of Obstetrics Gynecology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Fertil Steril 97:134-40.e1. 2012
  4. pmc Anti-mullerian hormone as a predictor of time to menopause in late reproductive age women
    Ellen W Freeman
    Department of Obstetrics Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 97:1673-80. 2012
  5. ncbi Data-driven assessment of the human ovarian reserve
    T W Kelsey
    School of Computer Science, University of St Andrews, St Andrews KY16 9SX, UK
    Mol Hum Reprod 18:79-87. 2012
  6. pmc Genetically determined dosage of follicle-stimulating hormone (FSH) affects male reproductive parameters
    Marina Grigorova
    Human Molecular Genetics Research Group, Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
    J Clin Endocrinol Metab 96:E1534-41. 2011
  7. ncbi Serum levels of anti-Müllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients
    Casper P Hagen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 95:5003-10. 2010
  8. ncbi Quad screen as a predictor of adverse pregnancy outcome
    Lorraine Dugoff
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Obstet Gynecol 106:260-7. 2005
  9. ncbi Production of inhibin A not B in rams: changes in plasma inhibin A during testis growth, and expression of inhibin/activin subunit mRNA and protein in adult testis
    A S McNeilly
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Reproduction 123:827-35. 2002
  10. ncbi The role of inhibins B and antimüllerian hormone for diagnosis and follow-up of granulosa cell tumors
    Inge Geerts
    Laboratory Medicine, Division of Gynecologic Oncology, University Hospitals Leuven, Leuven, Belgium
    Int J Gynecol Cancer 19:847-55. 2009

Detail Information

Publications335 found, 100 shown here

  1. ncbi Changes in expression of bone morphogenetic proteins (BMPs), their receptors and inhibin co-receptor betaglycan during bovine antral follicle development: inhibin can antagonize the suppressive effect of BMPs on thecal androgen production
    Claire Glister
    School of Biological Sciences, Hopkins Building, University of Reading, Whiteknights, Reading RG6 6UB, UK
    Reproduction 140:699-712. 2010
    ....
  2. ncbi A systematic review of tests predicting ovarian reserve and IVF outcome
    F J Broekmans
    Department of Reproductive Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands
    Hum Reprod Update 12:685-718. 2006
    ..As poor ovarian response will provide some information on OR status, especially if the stimulation is maximal, entering the first cycle of IVF without any prior testing seems to be the preferable strategy...
  3. pmc Impact of cancer therapies on ovarian reserve
    Clarisa R Gracia
    Department of Obstetrics Gynecology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Fertil Steril 97:134-40.e1. 2012
    ..To determine whether measures of ovarian reserve differ between females exposed to cancer therapies in a dose-dependent manner as compared with healthy controls of similar age and late reproductive age...
  4. pmc Anti-mullerian hormone as a predictor of time to menopause in late reproductive age women
    Ellen W Freeman
    Department of Obstetrics Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 97:1673-80. 2012
    ..Anti-mullerian hormone (AMH) has emerged as a marker of ovarian reserve and a possible surrogate measure of reproductive aging...
  5. ncbi Data-driven assessment of the human ovarian reserve
    T W Kelsey
    School of Computer Science, University of St Andrews, St Andrews KY16 9SX, UK
    Mol Hum Reprod 18:79-87. 2012
    ....
  6. pmc Genetically determined dosage of follicle-stimulating hormone (FSH) affects male reproductive parameters
    Marina Grigorova
    Human Molecular Genetics Research Group, Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
    J Clin Endocrinol Metab 96:E1534-41. 2011
    ..We have previously identified the association between the T-allele of the FSHB promoter polymorphism (rs10835638; G/T, -211 bp from the mRNA start) and significantly reduced male serum FSH...
  7. ncbi Serum levels of anti-Müllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients
    Casper P Hagen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 95:5003-10. 2010
    ..In adult women, anti-Müllerian hormone (AMH) is related to the ovarian follicle pool. Little is known about AMH in girls...
  8. ncbi Quad screen as a predictor of adverse pregnancy outcome
    Lorraine Dugoff
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Obstet Gynecol 106:260-7. 2005
    ....
  9. ncbi Production of inhibin A not B in rams: changes in plasma inhibin A during testis growth, and expression of inhibin/activin subunit mRNA and protein in adult testis
    A S McNeilly
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK
    Reproduction 123:827-35. 2002
    ....
  10. ncbi The role of inhibins B and antimüllerian hormone for diagnosis and follow-up of granulosa cell tumors
    Inge Geerts
    Laboratory Medicine, Division of Gynecologic Oncology, University Hospitals Leuven, Leuven, Belgium
    Int J Gynecol Cancer 19:847-55. 2009
    ..In conclusion, inhibin B and AMH are both useful serum markers for diagnosis and especially for follow-up of patients with a GCT. Currently, there is no evidence-based preference for inhibin B or AMH as tumor marker...
  11. ncbi Primary ovarian dysfunction contributes to the hypogonadism in women with Prader-Willi Syndrome
    Talia Eldar-Geva
    Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Horm Res 72:153-9. 2009
    ..To investigate the etiology of hypogonadism in women with Prader-Willi Syndrome (PWS)...
  12. ncbi Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha gene
    Brian M Gummow
    Department of Molecular and Integrative Physiology, Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:26572-9. 2003
    ..These data support the recent observation that beta-catenin can participate in nuclear receptor-mediated transcriptional activation and extend the findings to the monomer binding class of orphan nuclear receptors...
  13. ncbi Activin-binding protein from rat ovary is follistatin
    T Nakamura
    Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    Science 247:836-8. 1990
    ..A binding protein for activin was purified from rat ovary and was identical to follistatin, a specific inhibitor of FSH release. It is likely that the binding protein participates in the diverse regulatory actions of activin...
  14. ncbi Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls
    A M Andersson
    Department of Growth and Reproduction, Copenhagen University Hospital, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen OE, Denmark
    J Clin Endocrinol Metab 89:3161-7. 2004
    ..On the other hand, the parallel impairment of spermatogenesis and Leydig cells may reflect a congenital dysfunction of both compartments caused by a testicular dysgenesis during fetal/infant development...
  15. ncbi Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels
    A M Andersson
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 82:3976-81. 1997
    ....
  16. ncbi East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland
    Niels Jørgensen
    Department of Growth and Reproduction, Rigshospitalet, The Juliane Marie Centre, Copenhagen, Denmark
    Hum Reprod 17:2199-208. 2002
    ....
  17. ncbi Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol
    André Hazout
    ART Unit Eylau la Muette, Clinic La Muette, Paris, France
    Fertil Steril 82:1323-9. 2004
    ..To test the hypothesis that the concentration of early follicular phase serum antimullerian hormone (AMH) or mullerian-inhibiting substance (MIS) is a useful marker of ovarian response and assisted reproductive technology (ART) outcome...
  18. ncbi Anti-müllerian hormone is a promising predictor for the occurrence of the menopausal transition
    Ilse A J van Rooij
    Department of Reproductive Medicine, University Medical Center, 3584 CX, The Netherlands
    Menopause 11:601-6. 2004
    ..In this study we explored several markers for their ability to predict the occurrence of the transition to menopause...
  19. ncbi Depletion of ovarian reserve in young women after treatment for cancer in childhood: detection by anti-Müllerian hormone, inhibin B and ovarian ultrasound
    L E Bath
    Department of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
    Hum Reprod 18:2368-74. 2003
    ..Treatment of cancer during childhood may result in loss of primordial follicles from the ovary...
  20. ncbi First- and second-trimester maternal serum markers for aneuploidy and adverse obstetric outcomes
    Lorraine Dugoff
    Department of Obstetrics and Gynecology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Obstet Gynecol 115:1052-61. 2010
    ..This article reviews the relationships between these markers and adverse obstetric outcomes. In addition, potential management strategies and future areas of research are discussed...
  21. ncbi Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions
    C W Brown
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 25:453-7. 2000
    ..The novel phenotypes in these mice further illustrate the usefulness of insertion strategies for defining protein function...
  22. ncbi A prospective, comparative analysis of anti-Müllerian hormone, inhibin-B, and three-dimensional ultrasound determinants of ovarian reserve in the prediction of poor response to controlled ovarian stimulation
    Kannamannadiar Jayaprakasan
    Nottingham University Research and Treatment Unit in Reproduction, Division of Human Development, School of Clinical Sciences, University of Nottingham, Nottingham, Nottinghamshire NG7 2UH, United Kingdom
    Fertil Steril 93:855-64. 2010
    ....
  23. ncbi Estradiol and regulation of anti-Müllerian hormone, inhibin-A, and inhibin-B secretion: analysis of small antral and preovulatory human follicles' fluid
    Claus Yding Andersen
    Laboratory of Reproductive Biology, Section 5712, University Hospital of Copenhagen, Blegdamsvej 9, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:4064-9. 2006
    ..In ovaries surgically removed for fertility preservation, hormone concentrations in fluid from small antral follicles were determined. Levels were compared with those found in preovulatory follicular fluid...
  24. ncbi Synergistic activation of the inhibin alpha-promoter by steroidogenic factor-1 and cyclic adenosine 3',5'-monophosphate
    M Ito
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Mol Endocrinol 14:66-81. 2000
    ..We propose a model in which direct interactions of SF-1, CREB, and associated coactivators like CBP induce strongly cooperative transactivation by pathways that individually have relatively weak effects on transcription...
  25. ncbi All in the family: TGF-beta family action in testis development
    Catherine Itman
    Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton, Victoria 3168, Australia
    Reproduction 132:233-46. 2006
    ....
  26. pmc Antimullerian hormone and obesity: insights in oral contraceptive users
    Anne Z Steiner
    Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC 27599, USA
    Contraception 81:245-8. 2010
    ..The study was conducted to examine the impact of oral contraceptives (OCs) on serum antimullerian hormone (AMH) levels by obesity status in reproductive-age women...
  27. ncbi Circulating levels of inhibin A, activin A and follistatin in missed and recurrent miscarriages
    S Muttukrishna
    Department of Obstetrics and Gynaecology, Royal Free UCL Medical School, 86 96 Chenies Mews, London WC1E 6HX, UK
    Hum Reprod 17:3072-8. 2002
    ..The aim of this study was to investigate the changes in circulating levels and the clinical use of inhibin A, activin A and follistatin as endocrine markers of early pregnancy loss...
  28. ncbi Suppression of inhibin A biological activity by alterations in the binding site for betaglycan
    Yogeshwar Makanji
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    J Biol Chem 283:16743-51. 2008
    b>Inhibins A and B negatively regulate the production and secretion of follicle-stimulating hormone from the anterior pituitary, control ovarian follicle development and steroidogenesis, and act as tumor suppressors in the gonads...
  29. ncbi Immunohistochemical localization of inhibin/activin subunits in the wild ground squirrel (Citellus dauricus Brandt) ovary
    Xia Sheng
    College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, PR China
    J Reprod Dev 58:531-6. 2012
    ..The dynamic expression of inhibin/activin subunits indicated that they might play important paracrine and/or autocrine roles during the seasonal folliculogenesis of the wild ground squirrel...
  30. pmc A pilot study of predictive markers of chemotherapy-related amenorrhea among premenopausal women with early stage breast cancer
    Carey Anders
    Division of Medical Oncology, Duke University Department of Medicine, Durham, North Carolina, USA
    Cancer Invest 26:286-95. 2008
    ..Premenopausal women treated for early stage breast cancer (ESBC) are at risk for chemotherapy-related amenorrhea (CRA). Prospectively-validated, predictive markers of CRA are needed...
  31. ncbi Regulation of activin and inhibin in the adult testis and the evidence for functional roles in spermatogenesis and immunoregulation
    Mark P Hedger
    Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    Mol Cell Endocrinol 359:30-42. 2012
    ..Consequently, elevated activin A production within the testis during inflammation and infection may contribute to spermatogenic failure, fibrosis and testicular damage...
  32. ncbi Rat inhibin: molecular cloning of alpha- and beta-subunit complementary deoxyribonucleic acids and expression in the ovary
    T K Woodruff
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60201
    Mol Endocrinol 1:561-8. 1987
    ..Hybridization in situ to rat ovarian tissue demonstrates that both the alpha-inhibin and beta A-inhibin mRNAs are specifically expressed in granulosa cells of the developing follicles...
  33. pmc Cloning and sequence analysis of cDNA species coding for the two subunits of inhibin from bovine follicular fluid
    R G Forage
    Proc Natl Acad Sci U S A 83:3091-5. 1986
    ..These data establish that a 31-kDa form of inhibin also isolated from bovine follicular fluid, with subunits of 20 kDa (Ac) and 15 kDa (B), is derived from the 58-kDa form by proteolytic processing of the A subunit...
  34. ncbi Polycystic ovarian morphology in adolescents with regular menstrual cycles is associated with elevated anti-Mullerian hormone
    C Villarroel
    Institute of Maternal and Child Research, IDIMI, School of Medicine, University of Chile, Casilla 226 3, Santiago, Chile
    Hum Reprod 26:2861-8. 2011
    ..We also determined whether AMH could be used as a surrogate marker of PCOM during adolescence...
  35. ncbi Gonadal pathologies in transgenic mice expressing the rat inhibin alpha-subunit
    M L McMullen
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Endocrinology 142:5005-14. 2001
    ..The antagonist studies are consistent with a direct ovarian effect of the alpha-subunit transgene product mediated by changes in the inhibin-to-activin ratio in these mice...
  36. ncbi Inhibins and activins in pregnancy
    P Florio
    Chair of Obstetrics and Gynecology, Deaprtment of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    Mol Cell Endocrinol 225:93-100. 2004
    ..The measurement of inhibin A and activin A into the biological fluids of pregnancy will offer in the future further possibilities in early diagnosis, prediction, and monitoring pregnancy diseases...
  37. ncbi Abnormal second-trimester serum analytes are more predictive of preterm preeclampsia
    Richelle N Olsen
    Department of Reproductive Medicine, University of California at San Diego School of Medicine, San Diego, CA, USA
    Am J Obstet Gynecol 207:228.e1-7. 2012
    ..We sought to determine the association of abnormal second-trimester serum analytes with early preterm preeclampsia...
  38. ncbi Feedback regulation by inhibins A and B of the pituitary secretion of follicle-stimulating hormone
    Yogeshwar Makanji
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Vitam Horm 85:299-321. 2011
    b>Inhibins A and B are gonadal factors that negatively regulate FSH synthesis by the anterior pituitary...
  39. ncbi Changes in inhibins and activin secretion in healthy and pathological pregnancies
    P Florio
    Department of Obstetrics and Gynecology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100, Siena, Italy
    Mol Cell Endocrinol 180:123-30. 2001
    ..The availability of suitable assays developed in the last years has enabled the measurement of inhibins and activin A in their dimeric forms, in order to investigate their role in physiological conditions of pregnancy...
  40. ncbi Activin from secondary follicles causes small preantral follicles to remain dormant at the resting stage
    H Mizunuma
    Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Japan
    Endocrinology 140:37-42. 1999
    ..These results have suggested that secondary follicles cause primary follicles to become dormant at the resting stage by secreting activin...
  41. ncbi Activin A stimulates meiotic maturation of human oocytes and modulates granulosa cell steroidogenesis in vitro
    B M Alak
    Department of Obstetrics and Gynecology, The Ohio State University, Columbus 43210, USA
    Fertil Steril 70:1126-30. 1998
    ..To test the hypothesis that activin A promotes in vitro human oocyte meiotic maturation while inhibiting steroid secretion by nonluteinized antral granulosa cells...
  42. ncbi Statistically significant changes of antimüllerian hormone and inhibin levels during the physiologic menstrual cycle in reproductive age women
    Dorothea M Wunder
    Department of Obstetrics and Gynaecology, University of Berne, Berne, Switzerland
    Fertil Steril 89:927-33. 2008
    To define the dynamics of antimüllerian hormone (AMH) and inhibins during the physiologic menstrual cycle.
  43. ncbi Candidate genes for premature ovarian failure
    Nobuhiro Suzumori
    Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medicine, 1 Kawasumi, Nagoya 467 8601, Japan
    Curr Med Chem 14:353-7. 2007
    ..Studies in animal models provide new candidate genes for ovarian failure in humans...
  44. ncbi Characterization of inhibin/activin subunit, activin receptor, and follistatin messenger ribonucleic acid in human and mouse oocytes: evidence for activin's paracrine signaling from granulosa cells to oocytes
    Y Sidis
    Reproductive Endocrine Unit, Department of Obstetricsand Gynecology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Reprod 59:807-12. 1998
    ..Taken together with previous studies, these results indicate that oocytes may be capable of responding to, but not synthesizing, activin...
  45. ncbi Inhibin A is a follicle stimulating hormone-responsive marker of granulosa cell differentiation, which has both autocrine and paracrine actions in sheep
    B K Campbell
    Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh, UK
    J Endocrinol 169:333-45. 2001
    ..001). We conclude that inhibin A is an FSH-responsive marker of granulosa cell differentiation which has both autocrine and paracrine actions in sheep...
  46. pmc The stature of boys is inversely correlated to the levels of their sertoli cell hormones: do the testes restrain the maturation of boys?
    Kirstie Morgan
    Department of Anatomy and Structural Biology, Brain Health Research Centre, University of Otago, Dunedin, New Zealand
    PLoS ONE 6:e20533. 2011
    ..Consequently, the MIS/InhB slowing of male growth may have been historically advantageous, as it would minimizes any sex bias in the maternal cost of early child rearing...
  47. ncbi Sporadic hemangioblastoma of the kidney: an underrecognized pseudomalignant tumor?
    Yiu Tung Ip
    Department of Pathology, Queen Elizabeth Hospital, Hangzhou, Zhejiang, China
    Am J Surg Pathol 34:1695-700. 2010
    ....
  48. ncbi Production and purification of recombinant human inhibin and activin
    S A Pangas
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Endocrinol 172:199-210. 2002
    ..These proteins will be valuable for future analysis of inhibin and activin function and have been distributed to the US National Hormone and Peptide Program...
  49. ncbi Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
    K A Lewis
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 404:411-4. 2000
    Activins and inhibins, structurally related members of the TGF-beta superfamily of growth and differentiation factors, are mutually antagonistic regulators of reproductive and other functions...
  50. ncbi Relationships between serum hormone levels and semen quality among men from an infertility clinic
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, and Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, USA
    J Androl 28:397-406. 2007
    ..Additional consideration should be given to the utility of serum hormone levels as a surrogate for semen quality in epidemiologic studies in which the collection of semen is difficult due to logistical and/or volunteer rate constraints...
  51. ncbi Inhibins, activins and follistatin in reproduction
    D M de Kretser
    Centre for Molecular Reproduction and Endocrinology, Monash Institute of Reproduction and Development, Monash University, Clayton 3168, Victoria, Australia
    Hum Reprod Update 8:529-41. 2002
    ..In this review, the structure and physiology of the inhibins, activins and follistatin are discussed in terms of the evidence supporting their role as endocrine hormones, and ..
  52. ncbi Final height and gonad function after total body irradiation during childhood
    A C Couto-Silva
    Universite Paris Descartes, Unité d Endocrinologie Pédiatrique, AP HP, Hopital Bicetre, Le Kremlin Bicetre, France
    Bone Marrow Transplant 38:427-32. 2006
    ..005) concentrations. We concluded that the indications for GH treatment should be mainly based on the age at irradiation, taking into account the GH peak. The plasma FSH and inhibin B concentrations may predict sperm function...
  53. ncbi Comparison of ovarian function markers in users of hormonal contraceptives during the hormone-free interval and subsequent natural early follicular phases
    M H van den Berg
    Department of Pediatric Oncology Hematology, VU University Medical Center VUmc, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Hum Reprod 25:1520-7. 2010
    ..In addition, values measured on day 7 of the hormone-free interval were examined for the purpose of predicting values measured on days 2-5 during the second natural cycle...
  54. ncbi Reproductive hormone reference intervals for healthy fertile young men: evaluation of automated platform assays
    Ken Sikaris
    Royal College of Pathologists of Australasia and Australasian Association of Clinical Biochemists, Chemical Pathology Quality Assurance Programs Pty Ltd, Flinders Medical Centre, South Australia 5042, Australia
    J Clin Endocrinol Metab 90:5928-36. 2005
    ..Management of male infertility and/or androgen deficiency requires accurate hormonal measurements with valid reference intervals...
  55. ncbi Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 82:863-70. 2004
    ..To examine the relationship between body mass index (BMI) and semen quality among young men from the general population...
  56. ncbi Serum inhibin B as a marker of spermatogenesis
    F H Pierik
    Department of Andrology, University Hospital Dijkzigt Rotterdam, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 83:3110-4. 1998
    ..We conclude that inhibin B is the best available endocrine marker of spermatogenesis in subfertile men...
  57. ncbi Bovine follicle development is associated with divergent changes in activin-A, inhibin-A and follistatin and the relative abundance of different follistatin isoforms in follicular fluid
    Claire Glister
    School of Biological Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, UK
    J Endocrinol 188:215-25. 2006
    ....
  58. ncbi Different phenotypes for mice deficient in either activins or activin receptor type II
    M M Matzuk
    Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    Nature 374:356-60. 1995
    ..The striking lack of overlap between phenotypes of ActRcII-deficient and activin-deficient mice suggests that the ligands that signal through ActRcII during embryonic development are not activins...
  59. ncbi Inhibin is an antagonist of bone morphogenetic protein signaling
    Ezra Wiater
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 278:7934-41. 2003
    b>Inhibins are endogenous antagonists of activin signaling, long recognized as important regulators of gonadal function and pituitary FSH release...
  60. pmc The spectrum of phenotypes associated with mutations in steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) includes severe penoscrotal hypospadias in 46,XY males without adrenal insufficiency
    Birgit Kohler
    Developmental Endocrinology Research Group, UCL Institute of Child Health, University College London, London, UK
    Eur J Endocrinol 161:237-42. 2009
    ..We hypothesized that NR5A1 mutations could be identified in boys with hypospadias...
  61. ncbi Dynamic assays of inhibin B, anti-Mullerian hormone and estradiol following FSH stimulation and ovarian ultrasonography as predictors of IVF outcome
    Talia Eldar-Geva
    IVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Ben Gurion University of the Negev, Jerusalem 91031, Israel
    Hum Reprod 20:3178-83. 2005
    ....
  62. ncbi Follistatin binds to both activin and inhibin through the common subunit
    M Shimonaka
    Department of Molecular Endocrinology, Whittier Institute for Diabetes and Endocrinology, La Jolla, CA 92037
    Endocrinology 128:3313-5. 1991
    ..Therefore, these results suggest that follistatin binds to both activin and inhibin through the common beta-subunit...
  63. ncbi Comparison of preovulatory follicular concentrations of epidermal growth factor, insulin-like growth factor-I, and inhibins A and B in women undergoing assisted conception treatment with gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists
    Ulun Ulug
    Fertil Steril 87:995-8. 2007
    ..Similarly, follicular fluid levels of epidermal growth factor, insulin-like growth factor, and inhibins A and B were found not to be different...
  64. ncbi Expression of activin and inhibin subunits, receptors and binding proteins in human adrenocortical neoplasms
    J Hofland
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 65:792-9. 2006
    ..Expression of these activin-related mRNAs was measured in different types of adrenocortical tissues and tumours to study the relationship with tumorigenesis...
  65. ncbi Plasma inhibin A in heifers: relationship with follicle dynamics, gonadotropins, and steroids during the estrous cycle and after treatment with bovine follicular fluid
    E C Bleach
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom
    Biol Reprod 64:743-52. 2001
    ..This indicates that desensitization of gonadotropes to inhibin negative feedback is a contributory factor, together with reduced ovarian output of E, in generation of the post-bFF rebound in FSH...
  66. ncbi Neonatal exposure to estrogens suppresses activin expression and signaling in the mouse ovary
    Jingjing L Kipp
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208, USA
    Endocrinology 148:1968-76. 2007
    ..Estrogen also suppressed activin subunit gene promoter activities, suggesting a direct transcriptional effect. Overall, this study demonstrates that activin subunits are targets of estrogen action in the early mouse ovary...
  67. ncbi Inhibin B in male reproduction: pathophysiology and clinical relevance
    S J Meachem
    , Domagkstrasse 11, , Germany
    Eur J Endocrinol 145:561-71. 2001
    ..In summary, although inhibin B is a valuable index of spermatogenesis, the measurement of serum inhibin B levels is still of limited clinical relevance for individual patients...
  68. ncbi Hypogonadism in females with Prader-Willi syndrome from infancy to adulthood: variable combinations of a primary gonadal defect and hypothalamic dysfunction
    Talia Eldar-Geva
    Reproductive Endocrinology and Genetics Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, The Hebrew University, PO Box 3235, Jerusalem 91031, Israel
    Eur J Endocrinol 162:377-84. 2010
    ..Recent studies have documented primary testicular dysfunction in PWS males. Our aims were to characterize sexual development and reproductive hormones in PWS females and to investigate the etiology of hypogonadism...
  69. pmc Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome
    Deborah S Wachs
    Department of Reproductive Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0633, USA
    J Clin Endocrinol Metab 93:1827-33. 2008
    ..In women with polycystic ovary syndrome (PCOS), excess ovarian androgen production is driven by increased LH secretion. Studies conducted in animals suggest that the granulosa cell may influence LH-stimulated theca cell androgen production...
  70. ncbi Expression of activin/inhibin signaling components in the human adrenal gland and the effects of activins and inhibins on adrenocortical steroidogenesis and apoptosis
    T Vänttinen
    Department of Pediatrics, Kuopio University, Kuopio, Finland
    J Endocrinol 178:479-89. 2003
    Activins and inhibins are structurally related glycoprotein hormones modulating pituitary FSH secretion and gonadal steroidogenesis...
  71. ncbi First trimester levels of inhibins and activin A in normal and failing pregnancies
    Euan M Wallace
    Centre for Women s Health Research, Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Clayton, Victoria, Australia
    Clin Endocrinol (Oxf) 60:484-90. 2004
    ..We undertook this study to assess whether inhibin A, pro-alphaC inhibin and/or activin A, products of the corpus luteum and placenta, might be useful in either the prediction or diagnosis of miscarriage...
  72. ncbi Changes in serum inhibin levels and immunolocalization of inhibin/activin subunits during the breeding season in the wild male Japanese black bear (Ursus thibetanus japonicus)
    Qiang Weng
    Faculty of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China
    Endocrine 29:345-50. 2006
    ..These results suggest that Japanese black bear testes may secrete bioactive inhibins during the breeding season and that the circulating inhibin may be a useful indicator of the testicular function ..
  73. ncbi Inhibins in normal male physiology
    Anne E O'Connor
    Centre for Molecular Reproduction and Endocrinology, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Semin Reprod Med 22:177-85. 2004
    ..The availability of specific immunoassays for each of the isoforms has enabled the study of the individual inhibins and their physiological roles...
  74. ncbi The mouse inhibin alpha-subunit promoter directs SV40 T-antigen to Leydig cells in transgenic mice
    K Kananen
    Department of Physiology, University of Turku, Finland
    Mol Cell Endocrinol 119:135-46. 1996
    ..This gonadal tumor model is valuable for further studies on endocrine functions of Leydig cells and their tumorigenesis in vivo and in vitro...
  75. ncbi Reproductive deficiencies in transgenic mice expressing the rat inhibin alpha-subunit gene
    B N Cho
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Endocrinology 142:4994-5004. 2001
    ....
  76. ncbi Increased anti-Müllerian hormone serum concentrations in prepubertal daughters of women with polycystic ovary syndrome
    Teresa Sir-Petermann
    Laboratory of Endocrinology, Department of Medicine West Division, School of Medicine, University of Chile, Las Palmeras 299, Interior Quinta Normal, Casilla 33052, Correo 33, Santiago, Chile
    J Clin Endocrinol Metab 91:3105-9. 2006
    ..Adult women with polycystic ovary syndrome (PCOS) have increased levels of AMH associated with an excessive number of growing follicles. However, it is not known whether these abnormalities are present before the clinical onset of PCOS...
  77. ncbi Development and evaluation of a novel DNA vaccine expressing inhibin alpha (1-32) fragment for improving the fertility in rats and sheep
    Li Han
    College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China
    Anim Reprod Sci 109:251-65. 2008
    ..Our results revealed that inhibin DNA vaccine may be an alternative to the use of exogenous gonadotrophins for increasing ovarian follicular development and improving animal fertility...
  78. ncbi Inhibins, activins, and follistatin in the aging female and male
    Joshua M Hurwitz
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Semin Reprod Med 22:209-17. 2004
    Dimeric inhibins, activins, and follistatin (FS) were all initially characterized as reproductive endocrine hormones that regulate follicle-stimulating hormone (FSH) secretion...
  79. ncbi Antimüllerian hormone serum levels: a putative marker for ovarian aging
    Annemarie de Vet
    Department of Obstetrics and Gynecology, Division of Reproductive Medicine, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Fertil Steril 77:357-62. 2002
    ..To investigate whether serum concentrations of antimüllerian hormone may be used as a marker for ovarian aging...
  80. ncbi Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage
    Alka Prakash
    Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Jessop Wing, Sheffield, United Kingdom
    Fertil Steril 83:1758-63. 2005
    ..To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage...
  81. ncbi Regulation of cellular and system function by activin
    T K Woodruff
    Department of Medicine, Northwestern University, Chicago, IL 60611 3008, USA
    Biochem Pharmacol 55:953-63. 1998
    ..Activin antagonists (inhibins) and bioneutralizing binding proteins (follistatins) act as gating molecules to ensure accurate delivery of ..
  82. ncbi Differential effects of inhibin on gonadotropin stores and gonadotropin-releasing hormone binding to pituitary cells from cycling female rats
    G V Childs
    Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston 77555 1043, USA
    Endocrinology 138:1577-84. 1997
    ..These last effects are consistent with known reductions in FSH synthesis. The effects of inhibin on LH secretion may be secondary to the effects on Bio-GnRH receptors in bihormonal gonadotropes...
  83. ncbi Seasonal changes in spermatogenesis and immunolocalization of inhibin/activin subunits in the wild male ground squirrel (Citellus dauricus Brandt)
    Xia Sheng
    College of Biological Science and Technology, Beijing Forestry University, Beijing, China
    J Reprod Dev 54:460-4. 2008
    ....
  84. pmc Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis
    Michelle Myers
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 334:458-67. 2009
    ..Together, these data provide key evidence to suggest that regulation of the inhibin/activin system is essential for early folliculogenesis in the prepubertal mouse ovary...
  85. ncbi Immunodetection of inhibin in the human testis and epididymis during normal development and in non-tumoural testicular lesions
    Manuel Nistal
    Department of Pathology, La Paz Hospital, Paseo Castellana, 261, Madrid 28046, Spain
    Reprod Fertil Dev 22:558-63. 2010
    ..The data suggest that, in humans, inhibin is secreted by Sertoli cells into the seminiferous tubules and then travels towards the efferent ducts, where it is reabsorbed into the bloodstream...
  86. ncbi Nocturnal secretory dynamics of inhibin B and testosterone in pre- and peripubertal boys
    P M Crofton
    Department of Pediatric Biochemistry, Royal Hospital for Sick Children, Edinburgh EH9 1LF, United Kingdom
    J Clin Endocrinol Metab 89:867-74. 2004
    ..We conclude that both testosterone and inhibin B are related to nocturnal LH release in peripubertal boys but over different time scales...
  87. ncbi Changes of dimeric inhibin B levels in maternal serum throughout healthy gestation and in women with gestational diseases
    F Petraglia
    Department of Gynecology, Obstetrics and Pediatric Sciences, University of Modena, Italy
    J Clin Endocrinol Metab 82:2991-5. 1997
    ..Experimental studies have shown an effect of inhibins on placental hormone secretion, but an endocrine function is suggested by the high levels in maternal circulation...
  88. ncbi Dimeric inhibins in amniotic fluid, maternal serum, and fetal serum in human pregnancy
    E M Wallace
    Department of Obstetrics and Gynecology, University of Edinburgh, United Kingdom
    J Clin Endocrinol Metab 82:218-22. 1997
    ..Further, the presence of inhibin B in male fetuses is consistent with a testicular origin, suggesting that inhibin B may be important in the development of the fetal hypothalamo-pituitary-testicular axis...
  89. ncbi Interactions between follicle-stimulating hormone and growth factors in modulating secretion of steroids and inhibin-related peptides by nonluteinized bovine granulosa cells
    C Glister
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom
    Biol Reprod 65:1020-8. 2001
    ..This hypothesis was reinforced by the finding that addition of FS, to reduce the act A:FS ratio and sequester secreted activin, markedly suppressed (P < 0.001) FSH (3-fold)-, and LR3 IGF-I (2-fold)-induced E2 output...
  90. ncbi Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells
    Jianqi Liu
    Department of Pathology, Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland
    J Clin Endocrinol Metab 88:5002-8. 2003
    Activins and inhibins are often antagonistic in the regulation of ovarian function...
  91. ncbi Immunoreactivity of CD10 and inhibin alpha in differentiating hemangioblastoma of central nervous system from metastatic clear cell renal cell carcinoma
    Shih Ming Jung
    Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Mod Pathol 18:788-94. 2005
    ..In conclusion, in addition to the immunostaining of inhibin A, CD10 is a superior marker for distinguishing between a hemangioblastoma and a metastatic clear cell renal cell carcinoma...
  92. pmc Activins and inhibins: novel regulators of thymocyte development
    Paula Licona-Limón
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Circuito Escolar s n, Mexico, DF 04510, Mexico
    Biochem Biophys Res Commun 381:229-35. 2009
    Activins and inhibins are members of the transforming growth factor-beta superfamily that act on different cell types and regulate a broad range of cellular processes including proliferation, differentiation, and apoptosis...
  93. ncbi Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family
    K Tsuchida
    Institute for Enzyme Research, University of Tokushima, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    J Biol Chem 275:40788-96. 2000
    ..Our finding implies that cellular signaling by activin and BMPs is tightly regulated by multiple members of the follistatin family...
  94. ncbi An emerging role for co-receptors in inhibin signal transduction
    D J Bernard
    Department of Neurobiology and Physiology, Northwestern University, O.T. Hogan 4-150, 2153 N. Campus Drive, 60208, Evanston, IL, USA
    Mol Cell Endocrinol 180:55-62. 2001
    ..Several cell surface proteins that associate with inhibin have been identified recently, and these molecules may provide the clues necessary to understand how inhibin regulates reproductive function...
  95. ncbi Aberrantly increased mRNA expression of betaglycan, an inhibin co-receptor in the ovarian tissues in women with polycystic ovary syndrome
    Rui Zhu
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
    J Obstet Gynaecol Res 36:138-46. 2010
    To compare the gene expressional levels of receptors for activins and inhibins in ovarian tissues between women with polycystic ovary syndrome (PCOS) and normal controls, and to analyze their biologically relevant associations with serum ..
  96. ncbi Inhibins are the major activin ligands expressed during early thymocyte development
    Paula Licona
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Circuito Escolar s n, Mexico DF 04510
    Dev Dyn 235:1124-32. 2006
    ..much higher levels compared to betaA and betaB subunits, demonstrating for the first time the potential role of Inhibins as important mediators during early T cell development...
  97. pmc Inhibin A-subunit cDNAs from porcine ovary and human placenta
    K E Mayo
    Proc Natl Acad Sci U S A 83:5849-53. 1986
    ..The human precursor is highly homologous to its porcine counterpart and is predicted to generate an 18-kDa glycosylated inhibin A subunit...
  98. ncbi [Inhibins, activins and anti-Müllerian hormone: structure, signalling pathways, roles and predictive value in reproductive medicine]
    X Deffieux
    Service de gynécologie obstétrique et médecine de la reproduction, Hopital Tenon, 4, rue de la Chine, 75020 Paris, France
    Gynecol Obstet Fertil 31:900-11. 2003
    Anti-Müllerian hormone (AMH), inhibins and activins are members of the transforming growth factor (TGFbeta) superfamily and are known to have a variety of actions concerning reproduction, hormonogenesis, development processes and ..
  99. ncbi Isolation and characterization of native activin B
    T Nakamura
    Frontier Research Program, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    J Biol Chem 267:16385-9. 1992
    ....
  100. ncbi Sex differences in FSH-regulatory peptides in pubertal age boys and girls and effects of sex steroid treatment
    Carol M Foster
    Department of Pediatrics Endocrinology and the Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Reprod 19:1668-76. 2004
    ..FSH concentrations are higher in girls than in boys before puberty. We hypothesized that steroid-mediated changes in FSH-regulatory proteins underlie the sex differences in FSH secretion and pubertal timing...
  101. ncbi Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3
    Renato Fanchin
    Departments of Obstetrics and Gynecology and Reproductive Medicine, Clamart, France, and Biochemistry and Hormonology, Paris and Clamart, France
    Hum Reprod 18:323-7. 2003
    ..The study aim was to compare the relationship between serum anti-Müllerian hormone (AMH) levels and other markers of ovarian function with early antral follicle count on day 3...

Research Grants62

  1. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..By elucidating the interacting impact of declining ovarian and adrenal steroids on CNS function, we expect to lay a foundation for the development of therapies for many aging-associated disorders in women. ..
  2. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..In addition, when the boys reach adulthood, environmental risk factors for altered semen quality will also be explored. ..
  3. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..We also propose to extend the STRAW recommendations to be more broadly applicable to the range of women's diverse experience of reproductive aging. ..
  4. Use of a Fragile X premutation knock-in mouse to study FXPOI
    Joshua Johnson; Fiscal Year: 2013
    ..Hormonal assessment of PM carriers indicates that FSH is elevated, inhibins and anti-Mullerian hormone (both made by granulosa cells) are reduced...
  5. Functional Significance of the HIF1 Transcriptome in Granulosa Cells
    John H Nilson; Fiscal Year: 2013
    ..Moreover, understanding how FSH signals to direct follicular maturation can translate into safer and more effective treatments of infertility and early pregnancy loss as well as new approaches for contraceptive drugs. ..
  6. Center for Reproductive Research at Northwestern University
    Teresa K Woodruff; Fiscal Year: 2012
    ..Moreover, each of our continuing projects reaffirms our commitment to translate our findings to the bedside, and thereby contribute to the overall health of women. ..
  7. Role of Dicer in Gonadotrope and Reproductive Function
    T Rajendra Kumar; Fiscal Year: 2013
    ..Delineation of mechanisms of gonadotropin secretion is fundamental to physiology of reproduction and offers long-term clinical benefits of diagnosing and treating gonadotropin-dependent fertility/infertility disorders. ..
  8. Genetic Markers Associated with Epithelial Ovarian Cancer and Hypodontia
    Lorri A Morford; Fiscal Year: 2012
    ....
  9. Modulation of PAH ovarian toxicity by biotransformation enzyme polymorphisms
    Ulrike Luderer; Fiscal Year: 2010
    ..In so doing, they will also lay the groundwork for possible interventions to protect against ovarian dysfunction. ..
  10. Time to Conceive
    ANNE ZWEIFEL STEINER; Fiscal Year: 2010
    ..Given that unproven home urinary "fertility test" kits are already being marketed, a prospective study to determine their ability to predict fecundability and fertility in the general population is imperative. ..
  11. Maternal markers and prediction of preeclampsia
    Lorraine Dugoff; Fiscal Year: 2010
    ..Accomplishing either of these objectives would lead to reduced morbidity and mortality of both mothers and babies. ..
  12. TCF3: A Wnt Pathway Effector in Pluripotent Stem Cell Self-Renewal
    Marian L Waterman; Fiscal Year: 2013
    ..These studies could provide new insights into mechanisms regulating early human development. ..
  13. Prenatal Organochlorine Exposure and Male Reproduction
    PAM R FACTOR LITVAK; Fiscal Year: 2010
    ..This study represents the first large systematic evaluation of prenatal exposures to organochlorine compounds and male reproduction and has important implications for basic science, public health and public policy. ..
  14. Molecular Pathogenesis of Diamond Blackfan Anemia
    KATHLEEN MIHO SAKAMOTO; Fiscal Year: 2013
    ..Therefore, results from this work will improve the quality of life of DBA patients. ..
  15. Predictors of ovarian failure after chemotherapy in young breast cancer patients
    HUI CHUN IRENE SU; Fiscal Year: 2013
    ..These tools will assist young breast cancer patients and their physicians in making treatment decisions that would impact cancer survival and reproduction. ..
  16. Array Microscope Assay for Cancer Cell Mechanics
    Richard Superfine; Fiscal Year: 2013
    ..These measurements will validate our high throughput force system for a wide variety of cancer cell biology studies, enabling the elucidation of the biochemical and genetic determinants of metastatic behavior. ..
  17. Characterization and prevention of chemotherapy-induced damage to ovarian reserve
    Kutluk H Oktay; Fiscal Year: 2011
    ....
  18. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..S.; and (9) the population possesses unique characteristics for examining the proposed hypothesis, i.e., a stable workforce, a non-smoking group and excellent compliance rates. ..
  19. EXPRESSION OF OVARIAN INHIBIN AND ACTIVIN GENES
    Kelly Mayo; Fiscal Year: 1993
    ....
  20. INHIBIN GENE EXPRESSION IN TESTIS AND SERTOLI CELLS
    HUGH KEEPING; Fiscal Year: 1991
    ..The study of primate inhibin may also lead to a greater understanding of fertility and infertility in the human...
  21. SPERMATOGENESIS: SERTOLI-GERM CELL INTERACTION
    ANNA STEINBERGER; Fiscal Year: 1991
    ....
  22. Serum Inhibin B Levels in Male Polymer Production Worker
    Richard Lewis; Fiscal Year: 2000
    ..We believe that this investigation is novel and has the potential to be the foundation for meaningful medical surveillance for male reproductive toxicity. ..
  23. US STUDY OF SEMEN QUALITY IN PARTNERS OF PREGNANT WOMEN
    Shanna Swan; Fiscal Year: 2001
    ....
  24. GONADAL AND PHENOTYPIC SEX DIFFERENTIATION
    FREDRICK GEORGE; Fiscal Year: 1993
    ..A transplantation model will be developed to study the possible role of estrogen in urogenital tract development...
  25. Reversal of Infertility in Ovarian Failure
    Ayman Al Hendy; Fiscal Year: 2006
    ..Gene therapy is a rapidly developing field and may be a useful tool in treating several conditions in the area of women health that currently have no effective treatment available. ..
  26. ACTIVIN, INHIBIN AND FOLLISTATIN AND OSTEOBLASTOGENESIS
    Dana Gaddy; Fiscal Year: 2003
    ..The definition of the combined and respective contributions of these hormones during mouse osteoblastogenesis will provide insight into their potentially similar roles in cycling and post-menopausal women. ..
  27. Analysis of anti-growth properties of processed Follistatin proteins
    THEODOR HAERRY; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Members of the TGF-b family of growth factors (Activins/Inhibins/BMPs) are extracellular proteins that provide important signals during animal development...
  28. EFFECTS OF AGING ON THE REGULATION OF FSH SECRETION
    LOUIS DE PAOLO; Fiscal Year: 1990
    ..Finally, it is hoped that the data obtained from such studies may aid the gynecologist in developing a treatment which would effectively regulate the erratic nature of menstrual cycles normally observed during the menopausal transition...
  29. CHEMISTRY OF INHIBIN AND RELATED HORMONES
    DARRELL WARD; Fiscal Year: 1990
    ..The latter type of assay has been very useful in our functional group substitution experiments to learn something of the mechanism of action of thee glycoprotein hormones...
  30. Function of MAP2D in Granulosa Cells
    Mary Hunzicker Dunn; Fiscal Year: 2009
    ..Understanding how follicular maturation is regulated can translate into safer and more effective treatments for fertility. ..
  31. Ovarian Aspects of Caloric Restriction
    MARY ZELINSKI WOOTEN; Fiscal Year: 2004
    ..These studies will provide valuable insight into the potential impact of CR on the mechanisms of ovarian aging in primates. ..
  32. Effects of organochlorines on male infertility
    JULIA WIRTH; Fiscal Year: 2006
    ..abstract_text> ..
  33. OOCYTE COMPETENCY IN PRENATALLY ANDROGENIZED ANIMALS
    DANIEL DUMESIC; Fiscal Year: 2000
    ..and that these impairments are associated with abnormal follicular fluid concentrations of androgens and inhibins. Prenatally androgenized female rhesus monkeys will serve as a model for PCOS because they demonstrate LH ..
  34. St. John's Wort Effects on Levonorgestrel
    Patricia Murphy; Fiscal Year: 2006
    ..The study protocol will be refined for use in future studies of levonorgestrel and other emergency contraceptive regimens. ..
  35. REGULATION OF R55 EXPRESSION IN EARLY FOLLICULOGENESIS
    Vaughan Lee; Fiscal Year: 2002
    ....
  36. A High-Pressure Freezing and Cryoprocessing System for Northwestern University
    WILLIAM RUSSIN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. FACTORS REGULATING SYNTHESIS AND SECRETION OF LH AND FSH
    TORRANCE NETT; Fiscal Year: 1992
    ..The results should also aid in the design of more efficacious treatments for medical problems associated with gonadotropin synthesis and/or release...
  38. Mechanisms of activin antagonism
    Peter Gray; Fiscal Year: 2004
    Activins and their antagonists the inhibins play a critical role in regulating the pituitary gonadal axis. Betaglycan (BG) binds inhibin and facilitates antagonism of activin by inhibin...
  39. ROLE OF A GONADAL FSH BINDING COMPETITOR IN FSH ACTION
    Alan Schneyer; Fiscal Year: 1992
    ....
  40. OVARY SELECTIVE GENES: CRITICAL OVARIAN REGULATORS
    Eli Adashi; Fiscal Year: 2002
    ..Insight derived from this investigation may contribute to novel strategies for the promotion of fertility or its control. ..
  41. ACTIVIN AS AN FSH-RELEASING HORMONE
    JONATHAN WHEATON; Fiscal Year: 1993
    ....
  42. Breast Cancer Therapy by Differentiation Gene Activation
    Irma Russo; Fiscal Year: 2006
    ..abstract_text> ..
  43. OVARY-SELECTIVE KNOCKOUT OF IGF-I
    Eli Adashi; Fiscal Year: 2004
    ....
  44. DEVELOPMENTAL & FUNCTIONAL ROLES OF ACTIVIN & INHIBIN
    Martin Matzuk; Fiscal Year: 1993
    ..and biochemical characterization of the mutant mice produced in phase I; and 2) Crossbreeding of mice carrying these different mutant alleles in their germlines to produce mice deficient in several of the activins and inhibins.
  45. InhibinB as a Marker for Premenstrual Dysphoric Symptoms
    SHIRLEY HARTLAGE; Fiscal Year: 2007
    ..Results are expected to provide clues to the cause of PMDD, facilitate the now burdensome diagnostic process, and lead to new treatments. [unreadable] [unreadable] [unreadable]..
  46. MECHANISMS OF FSH-REGULATED GENE EXPRESSION
    Susan Hall; Fiscal Year: 1992
    ..The library will be screened using double stranded oligonucleotides corresponding to the mouse c-fos CRE and AP-1 regulatory elements. These experiments are designed to identify previously unknown mediators of FSH action...
  47. PHYSIOLOGICAL REGULATION OF GONADOTROPIN GENE EXPRESSION
    John Marshall; Fiscal Year: 2002
    ....
  48. REGULATION OF TESTICULAR INHIBIN/ACTIVIN GENE EXPRESSION
    CHING LING CHEN; Fiscal Year: 2000
    ..Aim 3 will investigate the developmental expression and hormonal regulation of GATA-binding proteins in the rat testis to determine whether any observed changes correlate to the known regulation of the a- and bB-subunit genes. ..
  49. Structural Determination of the E-Related Region of the TGFbeta type III receptor
    THOMAS MILLSTEAD; Fiscal Year: 2009
    ..Understanding the structural and functional role betaglycan plays in TGF(32 signaling, it will give vital insight into craniofacial development. ..
  50. HUMAN OVARIAN INHIBIN AND ITS SECRETION
    CORNELIA CHANNING; Fiscal Year: 1980
    ..Various hormones and other agents are being added to the cultured ovarian cell types and their secretion of inhibin measured using a rat anterior pituitary cell culture assay. Follicular inhibin is also being purified...
  51. Transcription Factor Interactions in Inhibin Regulation
    Kelly Mayo; Fiscal Year: 2002
    ..abstract_text> ..
  52. Cellular and Molecular Mechanisms of Inhibin Action on the Skeleton
    KRISTY NICKS; Fiscal Year: 2009
    ..The focus of this proposal is to determine the molecular mechanisms by which Inhibins exert a bimodal regulation on the skeleton such that short-term exposure represses osteoblastogenesis and long-..
  53. Inhibin/Activin Family in Human Cranifocial Development
    Geralyn Messerlian; Fiscal Year: 2003
    ..abstract_text> ..
  54. EPIDEMIOLOGIC STUDY OF THE LATE REPRODUCTIVE YEARS
    Ellen W Freeman; Fiscal Year: 2010
    ..abstract_text> ..
  55. CAREER DEVELOPMENT IN WOMEN'S HEALTH RESEARCH AND GENDE*
    Ellen Freeman; Fiscal Year: 2006
    ..The BIRCWH program will track the career trajectories of Scholars and will continue to serve as a resource in terms of career counseling and research advice. [unreadable] [unreadable]..
  56. Core symptoms and profiles in premenstrual syndrome
    Ellen Freeman; Fiscal Year: 2008
    ..Further information will contribute to improved health care for women in their reproductive years. [unreadable] [unreadable] [unreadable] [unreadable]..
  57. Reproductive Hormonal Effects of Weight Loss in Women
    Nanette Santoro; Fiscal Year: 2005
    ..Thus, this initial exploration, if positive, would provide the basis for a new line of investigation for the PI into the interactions between reproduction and metabolism. ..
  58. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  59. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2002
    ..abstract_text> ..
  60. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  61. Epidemiology of Ovarian Age
    Jennie Kline; Fiscal Year: 2003
    ..2. To conduct exploratory studies, using data from the Oocyte study, to assess whether or not skewed X-inactivation is associated with advanced ovarian age. ..