Genomes and Genes
Summary: Steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.
Publications241 found, 100 shown here
- Lack of estrogenic potential of progesterone- or 19-nor-progesterone-derived progestins as opposed to testosterone or 19-nor-testosterone derivatives on endometrial Ishikawa cellsJ Botella
Laboratoire Theramex, Preclinical Research and Development Department, Monaco, Monaco
J Steroid Biochem Mol Biol 55:77-84. 1995....
- Contrasting effects of estradiol and 17 beta-aminoestrogens on blood clotting time in rats and miceCristina Lemini
Departamento de Farmacologia, Facultad de Medicina, Edificio D, 1er piso, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico, D F, C P 04510, Apdo Postal 70 297, Mexico
Eur J Pharmacol 510:229-33. 2005..The maximum procoagulant effect of estradiol was obtained after 72 h with 10 microg/animal/day (-45%; P<0.01). 17 Beta-aminoestrogens always produced opposite effects to those of estradiol on blood coagulation...
- Effects of 17beta-aminoestrogens on the sexual behavior of female ratsC Lemini
Departamento de Farmacologia, UNAM Ciudad Universitaria, Apartado Postal 70 297, CP 04510, D F, Mexico
Physiol Behav 96:662-6. 2009..AEs LQDE50 values correlate with previous Uw DE50, LH ID50 and binding studies indicates mediation of the response by estrogen receptors. AEs facilitate sexual behavior of Ovx rats as partial estrogenic agonists...
- Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancerN Suh
Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Cancer Res 61:8412-5. 2001..Arzoxifene is devoid of the uterotrophic effects of tamoxifen, suggesting that, in contrast to tamoxifen, it is unlikely that the clinical use of arzoxifene will increase the risk of developing endometrial carcinoma...
- Effects of 17a-ethinylestradiol on the expression of three estrogen-responsive genes and cellular ultrastructure of liver and testes in male zebrafishMarkus Islinger
Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, D 69120, Heidelberg, Germany
Aquat Toxicol 62:85-103. 2003..Thus, in sexually differentiated males no reorganisation of the gonadal tissue towards an ovary could be definitely detected at any level investigated...
- The effects of estrogen administration on bone mineral density in adolescents with anorexia nervosaM T Muñoz
Department of Pediatrics, Division of Pediatric Endocrinology, Universidad Autonoma, Hospital Universitario Nino Jesus, Avda Menéndez Pelayo, 65, 28009 Madrid, Spain
Eur J Endocrinol 146:45-50. 2002..The aim of this work was to study the effect of prolonged AN on lumbar spine bone mineral density (BMD) and to determine whether oral estrogen administration prevents bone loss in women with this disorder...
- Detection of MDM2 alterations in cultured human hepatocytes treated with 17beta-estradiol or 17alpha-ethinylestradiolThilo Schlott
Department of Cytopathology, Georg August University, Goettingen, Germany
Anticancer Res 22:1545-51. 2002..Here we present the first report on the modulational effects of the steroids 17beta-estradiol (E2) and 17alpha-ethinylestradiol (EE2) on oncogene MDM2 in human hepatocytes...
- Effects of 17alpha-ethinylestradiol on the reproduction of the cladoceran species Ceriodaphnia reticulata and Sida crystallinaWolfgang Jaser
Institute of Ecological Chemistry, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, D 85764 Oberschleissheim, Germany
Environ Int 28:633-8. 2003..Negative consequences for the population dynamic cannot be excluded, e.g. the decrease of a population...
- Effects of 17beta-estradiol and xenoestrogens on the neuronal survival in an organotypic hippocampal cultureKaoru Sato
Division of Pharmacology, National Institute of Health Sciences, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
Neuroendocrinology 76:223-34. 2002..These results suggest that exposure to E(2) and xenoestrogens during the developmental stage results in a marked influence on synaptogenesis and neuronal vulnerability through mechanisms other than ERs...
- Bone mineral density in young, hypothalamic oligoamenorrheic women treated with oral contraceptivesC Castelo-Branco
Obstetric-Gynecologic Clinic, Department of Nuclear Medicine, and Hormone and Biochemistry Laboratories, Hospital Clinic, Faculty of Medicine, University of Barcelona, Villarroel 170, 08036-Barcelona, Spain
J Reprod Med 46:875-9. 2001..4%; B, 2.5%), while group C showed a significant decrease (1.2%, P < .05). CONCLUSION: Both doses of EE were equally effective in preventing bone loss related to hypoestrogenism in hypothalamic oligoamenorrheic subjects...
- Effects of two oral contraceptives, containing 30 or 20 microg of ethinyl estradiol in combination with gestodene, on blood coagulation and fibrinolysis in Brazilian womenA C Ferreira
Department of Clinical, Toxicological and Bromatological Analysis, , , Brazil
Int J Fertil Womens Med 46:265-70. 2001....
- Effects of sewage effluent and ethynyl oestradiol upon molecular markers of oestrogenic exposure, maturation and reproductive success in the sand goby (Pomatoschistus minutus, Pallas)Craig D Robinson
Fisheries Research Services, Marine Laboratory, PO Box 101, Victoria Road, AB11 9DB, Aberdeen, UK
Aquat Toxicol 62:119-34. 2003....
- Estrogen inhibits development of yolk veins and causes blood clotting in transgenic medaka fish overexpressing estrogen receptorToshiyuki Kawamura
Center for Gene Science, Hiroshima University, Japan
Zoolog Sci 19:1355-61. 2002..These results indicate that activation of estrogen receptor caused the estrogen-induced developmental defects. Our results show that the transgenic embryos can be used to assay the blood clotting activity of estrogenic compounds in vivo...
- Reciprocal antagonism between estrogen receptor and NF-kappaB activity in vivoM J Evans
Women's Health Research/Cardiovascular, Wyeth-Ayerst Research, Radnor, PA 19087, USA
Circ Res 89:823-30. 2001..These results suggest that the cross-talk between ER and NF-kappaB does occur in vivo and may indeed contribute significantly to the cardioprotective effects of estrogen...
- Beta-naphthoflavone inhibits the induction of hepatic oestrogen-dependent proteins by 17alpha-ethynylestradiol in mosquitofish (Gambusia holbrooki)E Aubry
INRA, SCRIBE, Rennes, France
Biomarkers 10:439-55. 2005....
- Exposure to 17 alpha-ethinylestradiol and bisphenol A--effects on larval moulting and mouthpart structure of Chironomus ripariusMatthew M Watts
School of Biosciences, Cardiff University, P O Box 915, Cardiff CF10 3TL, UK
Ecotoxicol Environ Saf 54:207-15. 2003..The relevance of these results in relation to the identification of an "endocrine-sensitive" endpoint for invertebrates is discussed...
- Effects of 17 alpha-ethinylestradiol on sexual development of the amphipod Hyalella aztecaGert F Vandenbergh
Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, J Pateaustraat 22, 9000 Ghent, Belgium
Ecotoxicol Environ Saf 54:216-22. 2003..These findings provide evidence that sexual development of H. azteca is affected by exposure to sublethal concentrations of EE...
- Intrauterine bisphenol A exposure leads to stimulatory effects on Sertoli cell number in ratsJoachim Wistuba
Institute of Reproductive Medicine of the University, Domagkstrasse11, 48149 Munster, Germany
Environ Res 91:95-103. 2003....
- Optimizing the dose of hormone replacement therapyValerie Montgomery Rice
Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Int J Fertil Womens Med 47:205-10. 2002..It is in these areas that the decision on the dose and the addition of a progestin to hormone replacement therapy is under review...
- Transdermal contraception: evaluation of three transdermal norelgestromin/ethinyl estradiol doses in a randomized, multicenter, dose-response studyRichard Dittrich
Partners in Women s Health, Methodist Hospital, Philadelphia, PA, USA
Am J Obstet Gynecol 186:15-20. 2002..The objective of this study was to identify the dose for a contraceptive patch that provides a predetermined level of ovulation suppression and cycle control and that is well tolerated...
- The potential for estradiol and ethinylestradiol to sorb to suspended and bed sediments in some English riversKarlijn I E Holthaus
Centre for Ecology and Hydrology, Wallingford, Oxon OX10 8BB, United Kingdom
Environ Toxicol Chem 21:2526-35. 2002..In the bed sediments, higher Kd values were associated with smaller particle size and higher organic carbon content. In most cases, the Kd values obtained for EE2 were higher than those for E2 by a factor of up to three...
- Effect of ethinylestradiol on the reproduction and induction of vitellogenin and testis-ova in medaka (Oryzias latipes)Masanori Seki
Chemicals Evaluation and Research Institute, Japan, Kurume shi, Fukuoka
Environ Toxicol Chem 21:1692-8. 2002..This suggests that the elevated VTG levels and testis-ova may not be definitely responsible for reproductive impairment of the fish...
- Pubertal exposure to estrogenic chemicals affects behavior in juvenile and adult male ratsDaniele Della Seta
Department of Physiology, Section of Neuroscience and Applied Physiology, University of Siena, 53100 Siena, Italy
Horm Behav 50:301-7. 2006..This can be due to the much higher estrogenic potency of EE; the direction of the behavioral effects of BPA, compared with EE, is however indicative of an estrogenic mechanism...
- Determination of estrogens in sludge and sediments by liquid extraction and GC/MS/MSThomas A Temes
ESWE Institute for Water Research and Water Technology, Wiesbaden, Germany
Anal Chem 74:3498-504. 2002..9 ng/g. Mestranol, a prodrug for 17alpha-ethinylestradiol, was not detected either in sludge or in sediments...
- Isolation and characterization of the ethynylestradiol-biodegrading microorganism Fusarium proliferatum strain HNS-1J H Shi
Department of Chemical Engineering, Tokyo University of Agriculture and Technology, 2 24 16 Naka, Koganei, Tokyo 184 8588, Japan
Water Sci Technol 45:175-9. 2002..L-1, with a first-order rate constant of 0.6 d-1. Unknown products of EE2 degradation, which may be more polar compounds that have a phenolic group, remained in the culture medium...
- Dose-response and time course relationships for vitellogenin induction in male western fence lizards (Sceloporus occidentalis) exposed to ethinylestradiolSandra M Brasfield
Department of Zoology, Oklahoma State University, Stillwater 74078, USA
Environ Toxicol Chem 21:1410-6. 2002..In conclusion, our data show that plasma ALP may be a suitable alternative for measuring plasma Vtg compared with developing a Vtg ELISA in fence lizards exposed to estrogenic compounds...
- Estrogen receptor alpha inhibits IL-1beta induction of gene expression in the mouse liverMark J Evans
Wyeth Research, Collegeville, Pennsylvania 19426, USA
Endocrinology 143:2559-70. 2002..Together, these results are consistent with a model of in vivo ER interference with IL-1beta signaling through a coactivator-based mechanism...
- [Low-dose combination oral contraceptives use in women with uterine leiomyomas]G Orsini
III Unità Operativa di Ginecologia e Ostetricia, Cattedra di Fisiopatologia della Riproduzione Umana, Dipartimento di Scienze Chirurgiche, Universita degli Studi, Bari, Italy
Minerva Ginecol 54:253-61. 2002..To evaluate the effects of the last generation of oral contraceptives (OC) on uterine leiomyomas...
- Long-lasting intestinal bleeding in an old patient with multiple mucosal vascular abnormalities and Glanzmann's thrombasthenia: 3-year pharmacological managementA Coppola
Centro di Coordinamento Regionale per le Emocoagulopatie, Cattedra di Gastroenterologia, Dipartimento di Medicina Clinica e Sperimentale, Universita Federico II, Napoli, Italy
J Intern Med 252:271-5. 2002....
- Toxicity of 17alpha-ethinylestradiol and bisphenol A to the freshwater Cnidarian Hydra vulgarisD Pascoe
School of Biosciences, Main Building, Cardiff University, P O Box 915, Cardiff CF10 3TL, UK
Arch Environ Contam Toxicol 43:56-63. 2002..vulgaris are not disrupted by estrogenic pollutants at low environmentally relevant concentrations...
- Estradiol, but not raloxifene, improves aspects of spatial working memory in aged ovariectomized rhesus monkeysAGNES LACREUSE
Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA
Neurobiol Aging 23:589-600. 2002..Further, they suggest that raloxifene does not affect cognitive function after long-term ovarian hormone deprivation...
- Choriogenin mRNA induction in male medaka, Oryzias latipes as a biomarker of endocrine disruptionChulwoo Lee
Risk Research Department, National Institute of Environmental Research, Gyeongseo dong, Seo Gu, Incheon 404 170, South Korea
Aquat Toxicol 61:233-41. 2002..The induction of choriogenin subunits expression by these chemicals showed a dose-dependent pattern and choriogenin L was found to be more sensitive than choriogenin H...
- Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the "Enhanced OECD Test Guideline no. 407"Kanji Yamasaki
Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
Arch Toxicol 76:65-74. 2002....
- The potential for estradiol and ethinylestradiol degradation in English riversMonika D Jürgens
Centre for Ecology and Hydrology, Wallingford, Oxon, United Kingdom
Environ Toxicol Chem 21:480-8. 2002..Compared to E2, EE2 was much more resistant to biodegradation, but both E2 and EE2 were susceptible to photodegradation, with half-lives in the order of 10 d under ideal conditions...
- Environmental estrogens interact with and modulate the properties of plasma sex steroid-binding proteins in juvenile Atlantic salmon (Salmo salar)Knut Erik Tollefsen
Department of Biology, University of Oslo, Norway
Mar Environ Res 54:697-701. 2002..and give additional answers to the question why some weakly acting xenoestrogens are causing "estrogen-like" reproductive disturbances in developing males...
- Effects of an environmental estrogen, 17alpha-ethinyl-estradiol, on the maternal-fetal trophic relationship in the eelpout Zoarces viviparus (L)B Korsgaard
Institute of Biology, SDU, Odense University, Denmark
Mar Environ Res 54:735-9. 2002..These and other metabolic observations indicate that exposure to different doses of EE2 and to estradiol-17beta affects the maternal-fetal trophic relationship...
- Waterborne ethynylestradiol induces vitellogenin and alters metallothionein expression in lake trout (Salvelinus namaycush)Julieta Werner
Department of Zoology, University of Manitoba, Winnipeg, Canada R3T 2N2
Aquat Toxicol 62:321-8. 2003..Further studies to examine the specific links between estrogen exposure, VTG induction and regulation of essential metals like Zn are required...
- Comparison of ELISAs for detecting vitellogenin in the fathead minnow (Pimephales promelas)Eve Mylchreest
DuPont Haskell Laboratory for Health and Environmental Sciences, Elkton Road, PO Box 50, Newark, DE 19714, USA
Comp Biochem Physiol C Toxicol Pharmacol 134:251-7. 2003..The homologous fVTG assay is recommended to achieve accurate quantification of VTG levels in fathead minnows...
- Gene expression profile in the livers of rats orally administered ethinylestradiol for 28 days using a microarray techniqueNatsumi Kato
Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
Toxicology 200:179-92. 2004..0 ppm, up-regulation of genes dose-dependently in females provides a sensitive tool to detect estrogenic effects in the rat liver in the framework of the 28-day toxicity study...
- Mixtures of estrogenic contaminants in bile of fish exposed to wastewater treatment works effluentsR Gibson
Centre for Environmental Research, Chichester Building, University of Sussex, Falmer, Brighton BN1 9QJ, UK
Environ Sci Technol 39:2461-71. 2005..K. rivers. The composition of the mixture of estrogenic contaminants in the bile is species dependent and may determine the susceptibility of fish to the effects of exposure to estrogenic effluents...
- The effect of a selective estrogen receptor modulator on the progression of spontaneous autoimmune disease in MRL lpr/lpr miceL D Apelgren
Division of Cardiovascular Research, Lilly Research Labs, Indianapolis, Indiana 46285, USA
Cell Immunol 173:55-63. 1996..These studies demonstrate that SERMs may be potentially useful for the treatment of autoimmune disorders...
- Estimating the effects of 17alpha-ethinylestradiol on populations of the fathead minnow Pimephales promelas: are conventional toxicological endpoints adequate?Eric P M Grist
School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, United Kingdom
Environ Sci Technol 37:1609-16. 2003..The significance of these summary statistics when deriving environmental benchmarks for steroid estrogens is discussed in the context of affording protection to populations following long-term exposure...
- Contrasting effects of two hormone replacement therapies on the cardiovascular and mammary gland outcomes in surgically postmenopausal monkeysIrma H Suparto
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Am J Obstet Gynecol 188:1132-40. 2003....
- Developmental estrogenic exposure in zebrafish (Danio rerio): II. Histological evaluation of gametogenesis and organ toxicityLynn P Weber
Department of Zoology, Oklahoma State University, 430 Life Sciences West, Stillwater, OK 74078, USA
Aquat Toxicol 63:431-46. 2003....
- Ortho Evra/Evra versus oral contraceptives: follicular development and ovulation in normal cycles and after an intentional dosing errorRoger A Pierson
Obstetrics, Gynecology, and Reproductive Sciences, University of Saskatchewan, Saskatoon, Canada
Fertil Steril 80:34-42. 2003..To compare the effects of the contraceptive patch to oral contraceptives (OCs) on follicular size and incidence of ovulation in normal cycles and after dosing errors...
- Effects of 17alpha-ethynylestradiol in a partial life-cycle test with zebrafish (Danio rerio): effects on growth, gonads and female reproductive successK Van den Belt
Environmental Toxicology, Flemish Institute for Technological Research VITO, Boeretang 200, Mol B 2400, Belgium
Sci Total Environ 309:127-37. 2003....
- Systemic and histopathologic changes in Beagle dogs after chronic daily oral administration of synthetic (ethinyl estradiol) or natural (estradiol) estrogens, with special reference to the kidney and thyroidI Zayed
N V Organon, Oss, The Netherlands
Toxicol Pathol 26:730-41. 1998..The renal and thyroid changes did not alter clinicopathological function tests for either of these organs. These 2 new findings extend the list of estrogen-related effects in the dog...
- Toxicity of 17alpha-ethynylestradiol and norethindrone, constituents of an oral contraceptive pill to the swimming and reproduction of cladoceran Daphnia magna, with special reference to their synergetic effectTakashi Goto
Graduate School of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, 252 8510, Kanagawa, Japan
Mar Pollut Bull 47:139-42. 2003..This result indicates the importance of examining synergetic effects of chemicals in the context of natural environments which face exposure to myriad chemicals...
- Removal of estrogenic activities of 17beta-estradiol and ethinylestradiol by ligninolytic enzymes from white rot fungiKazutaka Suzuki
Department of Forest Resources Science, Faculty of Agriculture, Shizuoka University, Ohya 836, Japan
Water Res 37:1972-5. 2003..These results strongly suggest that these ligninolytic enzymes are effective in removing the estrogenic activities of E(2) and EE(2)...
- Effects of 17alpha-ethinylestradiol on immune parameters in the lizard Sceloporus occidentalisD Kim Burnham
Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078, USA
Environ Toxicol 18:211-8. 2003..These effects probably involve mechanisms other than or in addition to the induction of cortisol release...
- Synthetic estrogen-mediated activation of ERK 2 intracellular signaling moleculeS Prifti
Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, Ruprechts Karls Universitaet, Heidelberg, Germany
Gynecol Endocrinol 17:423-8. 2003..Ethinylestradiol as used in oral contraceptives, and 17 beta-estradiol and 17 beta-estradiol valerate as used in hormone replacement therapy, are able to activate MAP kinase. This activation was blocked by an antiestrogen...
- Regulation of sex hormone-binding globulin secretion in human hepatoma G2 cellsK Browne-Martin
Departments of Obstetrics/Gynecology and Medicine, University of Massachusetts Medical Center, Worcester, MA 01655, USA
Steroids 66:605-7. 2001..In addition, TAM stimulates SHBG secretion by interaction with the genome that is different, in certain respects, from that of E2...
- Synthetic estrogens-mediated activation of JNK intracellular signaling moleculeS Prifti
Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, Ruprechts-Karls-Universitaet, Heidelberg, Germany
Gynecol Endocrinol 15:135-41. 2001..The estrogen receptor is necessary for JNK activation upon estrogen stimulation...
- HPLC-fluorescence detection and adsorption of bisphenol A, 17beta-estradiol, and 17alpha-ethynyl estradiol on powdered activated carbonYeomin Yoon
Department of Civil and Environmental Engineering, Arizona State University, ECG 252, Tempe, AZ 85287 5306, USA
Water Res 37:3530-7. 2003..This study confirms that PAC treatment is feasible for >99% removal of three estrogenic compounds from raw drinking waters that may be at risk for containing such compounds, at least at initial concentration of 500 ng/l and higher...
- Effects of 3-phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]- 2H-1-benzopyran-7-ol (CHF 4056), a novel nonsteroidal estrogen agonist/antagonist, on reproductive and nonreproductive tissueElisabetta Galbiati
Department of Pharmacology, Chiesi Pharmaceuticals S p A, Parma, Italy
J Pharmacol Exp Ther 300:802-9. 2002..In conclusion, CHF 4056 is a new SERM that produces beneficial effects on bone and cholesterol levels, while maintaining antagonist effects on the uterus...
- The influence of dietary isoflavone on the uterotrophic response in juvenile ratsMichael G Wade
Environmental and Occupational Toxicology Division, Healthy Environments and Consumer Safety Branch, Room 315, Environmental Health Centre, PL 0803D, Tunney s Pasture, Ottawa, Ontario, Canada K1A 0L2
Food Chem Toxicol 41:1517-25. 2003....
- Relative potencies and combination effects of steroidal estrogens in fishKaren L Thorpe
School of Biological Sciences, The Hatherly Laboratory, Exeter University, The Prince of Wales Road, Exeter, Devon, EX4 4PS, UK
Environ Sci Technol 37:1142-9. 2003....
- Steroid estrogens profiles along river stretches arising from sewage treatment works dischargesRichard J Williams
Centre for Ecology and Hydrology, Wallingford, Oxfordshire, OX10 8BB, UK
Environ Sci Technol 37:1744-50. 2003..The most likely cause of this decline is a combination of sorption and biodegradation equivalent to a first-order decay half-life of 2.5 days for the River Nene and 0.5 days for the River Lea...
- Effects of estradiol and aging on fine manual performance in female rhesus monkeysAGNES LACREUSE
Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
Horm Behav 43:359-66. 2003..These results confirm the slowing of fine motor performance with aging in female rhesus monkeys. They also indicate that estradiol, at least as administered in this study, does not benefit fine manual performance...
- Effect-directed analysis of key toxicants in European river basins a reviewWerner Brack
UFZ Centre for Environmental Research, Department of Effect Directed Analysis, Leipzig, Germany
Environ Sci Pollut Res Int 14:30-8. 2007..Thus, one focus of present European research is on toxicant identification in European river basins in order to allow for a reduction of toxic pressure on aquatic ecosystems according to the WFD...
- Synthesis of the catechols of natural and synthetic estrogens by using 2-iodoxybenzoic acid (IBX) as the oxidizing agentMuhammad Saeed
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Steroids 70:173-8. 2005..This method is highly efficient for the preparative scale synthesis of catechols of both natural and synthetic estrogens...
- Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's diseaseLiqin Zhao
Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
BMC Neurosci 7:24. 2006..Further, we sought, through computer-aided modeling analyses, to investigate the potential correlation of the molecular mechanisms that conferred estrogen neuroprotection with estrogen interactions with the estrogen receptor (ER)...
- Hormonal action of plant derived and anthropogenic non-steroidal estrogenic compounds: phytoestrogens and xenoestrogensT Lorand
Department of Biochemistry and Medical Chemistry, University of Pecs, Medical School, Pecs, Hungary
Curr Med Chem 17:3542-74. 2010..Better understanding of the molecular pharmacology of phyto- and xenoestrogens may result in the development of novel compounds with therapeutic utility and improved environmental protection...
- Effects of natural and synthetic estrogens and various environmental contaminants on vitellogenesis in fish primary hepatocytes: comparison of bream (Abramis brama) and carp (Cyprinus carpio)T Rouhani Rankouhi
Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD, The Netherlands
Toxicol Sci 81:90-102. 2004..Due to their anti-estrogenic capacity with benchmark-concentrations in the pM range TCDD, PCDF, and PCB126 may form a potential hazard for the reproductive success of fish species by inhibition of vitellogenesis...
- Stimulation of alkaline phosphatase activity in Ishikawa cells induced by various phytoestrogens and synthetic estrogensJannette Wober
Molecular Cell Physiology and Endocrinology, Institute of Zoology, Dresden University of Technology, Mommsenstr 13, 01062 Dresden, Germany
J Steroid Biochem Mol Biol 83:227-33. 2002..The latter result demonstrated the estrogen receptor dependency of this process. In summary, most of the phytoestrogens and industrial chemicals tested, behaved as estrogen receptor agonists in terms of the stimulation of AlkP activity...
- Estrogen-independent expression of neuropsin, a serine protease in the vagina of mice exposed neonatally to diethylstilbestrolYoshinao Katsu
Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki 444 8585, Japan
Mol Cell Endocrinol 195:99-107. 2002..This is the first report on the gene expression of a serine-protease neuropsin in the mouse vagina, and as a marker of the estrogen-independent persistent proliferation and cornification of the vaginal epithelium...
- Presence of natural and anthropogenic organic contaminants and potential fish health impacts along two river gradients in Alberta, CanadaKen M Jeffries
Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
Environ Toxicol Chem 29:2379-87. 2010..Therefore, many activities within these basins impact water quality in the South Saskatchewan River Basin and affect endemic longnose dace populations...
- Transcription-modulating drugs: mechanism and selectivityW Cai
Oncogene Science Inc, 106 Charles Lindbergh Boulevard, Uniondale, NY 11553, USA
Curr Opin Biotechnol 7:608-15. 1996....
- Determination of estrogens in wastewater using three-phase hollow fiber-mediated liquid-phase microextraction followed by HPLCMeihua Liu
Ministry of Education, Key Laboratory of Analysis and Detection Technology for Food Safety Fuzhou University, Department of Chemistry, Fuzhou University, Fuzhou, Fujian, China
J Sep Sci 31:622-8. 2008..The determination limit at an S/N of 3 ranged from 0.25 to 0.5 microg/L for the estrogens. The recovery ratio was more than 86% in the determination of these estrogens in wastewater...
- Impact of oral contraceptives on sex hormone-binding globulin and androgen levels: a retrospective study in women with sexual dysfunctionClaudia Panzer
Department of Endocrinology, Boston University Medical Center, Boston, MA, USA
J Sex Med 3:104-13. 2006..OC use is associated with a decrease of androgen ovarian synthesis and an increase in the production of sex hormone-binding globulin (SHBG). There have been limited studies assessing SHBG values after discontinuation of OC use...
- Catechol quinones of estrogens in the initiation of breast, prostate, and other human cancers: keynote lectureErcole Cavalieri
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 8198 6805, USA
Ann N Y Acad Sci 1089:286-301. 2006..This unifying mechanism of the origin of cancer and other diseases suggests preventive strategies based on the level of depurinating DNA adducts that generate the first critical step in the initiation of diseases...
- Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cellsFei Wu
Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX, United States
J Steroid Biochem Mol Biol 103:1-9. 2007..These data suggest that xenoestrogens are selective ER modulators (SERMs)...
- A unifying mechanism in the initiation of cancer and other diseases by catechol quinonesErcole L Cavalieri
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Ann N Y Acad Sci 1028:247-57. 2004..In summary, the apurinic sites produced in DNA from the loss of these depurinating adducts can be converted into mutations by error-prone repair, which may initiate cancer and other diseases...
- The unusual binding properties of the third distinct teleost estrogen receptor subtype ERbetaa are accompanied by highly conserved amino acid changes in the ligand binding domainM B Hawkins
Department of Zoology, North Carolina State University, Box 7617, Raleigh, North Carolina 27695, USA
Endocrinology 145:2968-77. 2004....
- Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancersDeodutta Roy
Department of Environmental and Occupational Health, Florida International University, Miami, Florida 33199, USA
J Toxicol Environ Health B Crit Rev 10:235-57. 2007....
- The co-mitogenic effects of various estrogens for TGF-alpha-induced DNA synthesis in cultured female rat hepatocytesN Ni
Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205
Cancer Lett 84:133-40. 1994..In addition, enhancement of TGF-alpha-induced DNA synthesis by conditioned medium from E2-treated cells supports the notion that a metabolite mediates its co-mitogenic effect...
- New stably transfected bioluminescent cells expressing FLAG epitope-tagged estrogen receptors to study their chromatin recruitmentEric Badia
IRCM, Institut de Recherche en Cancérologie de Montpellier, F 34298 INSERM, U896, F 34298 Université Montpellier1, F 34298 CRLC Val d Aurelle Paul Lamarque, Montpellier, F 34298, France
BMC Biotechnol 9:77. 2009..The use of antibodies directed against the FLAG epitope allowed a direct comparative evaluation of the respective actions of both ERs using ChIP...
- Effects of neonatal administration of diethylstilbestrol in male hamsters: disruption of reproductive function in adults after apparently normal pubertal developmentS A Khan
Department of Cell Biology and Biochemistry and Southwest Cancer Center at the University Medical Center, Texas Tech University Health Sciences Center, Lubbock 79430, USA
Biol Reprod 58:137-42. 1998....
- Ligninase-mediated removal of natural and synthetic estrogens from water: II. Reactions of 17beta-estradiolLiang Mao
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, P R China
Environ Sci Technol 44:2599-604. 2010..Data obtained from E-SCREEN test confirmed that the estrogenicity of E2 can be effectively eliminated following sequential reactions mediated by LiP...
- Prenatal exposure of Long-Evans rats to 17alpha-ethinylestradiol modifies neither latent inhibition nor prepulse inhibition of the startle reflex but elicits minor deficits in exploratory behaviorGuy Sandner
U405 INSERM, Faculty of Medicine, Louis Pasteur University, 11 rue Humann, 67085 Strasbourg Cedex, France
Brain Res Dev Brain Res 152:177-87. 2004..This indicates that standard models of schizophrenia did not fit to the behavioral abnormalities found by others and confirmed in this study. They were not due to the abnormal maternal care to pups elicited by the treatment...
- Ligninase-mediated removal of 17beta-estradiol from water in the presence of natural organic matter: efficiency and pathwaysLiang Mao
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, PR China
Chemosphere 80:469-73. 2010..NOM moieties seemed to couple to each other upon reaction with LiP, which was evidenced by the development of a characteristic absorbance band...
- [Hormone replacement therapy in menopause and risk of breast cancer]F Clavel-Chapelon
INSERM U521, Institut Gustave Roussy, Villejuif
Presse Med 29:1688-93. 2000..Many epidemiological studies have analysed the relation between hormonal replacement therapy and risk of breast cancer. We present here a synthesis of the available results...
- Toxicology of environmental estrogensS H Safe
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
Reprod Fertil Dev 13:307-15. 2001..For example, BPA inhibits E2-induced responses in the rodent uterus, and HPTE and structurally related compounds are ERalpha agonists and ERbeta antagonists in assays carried out in HepG2 and other cancer cell lines...
- Vitellogenin as a biomarker for estrogenic effects in brown trout, Salmo trutta: laboratory and field investigationsPoul Bjerregaard
Institute of Biology, 55, Campusvej, DK 5230 Odense M, Denmark
Environ Toxicol Chem 27:2387-96. 2008..It is noteworthy, however, that exposure to synthetic estrogens (EE2, BP, and OP) resulted in higher liver concentrations (for the same plasma concentration) than exposure to the natural estrogens E1 and E2...
- Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: Insights into the structural determinants favoring a differential subtype bindingBao Ting Zhu
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Basic Pharmaceutical Sciences, College of Pharmacy, 700 Sumter Street, Columbia, South Carolina 29209, USA
Endocrinology 147:4132-50. 2006....
- Promotive effects of diethylstilbestrol, its metabolite (Z,Z-dienestrol) and a stereoisomer of the metabolite (E,E-dienestrol) in tumorigenesis of rat mammary glands pregnancy-dependently initiated with radiationH Inano
Division of Chemical Pharmacology, National Institute of Radiological Sciences, Chiba shi, Japan
Carcinogenesis 14:2157-63. 1993..The findings suggest that DES acts directly on radiation-initiated mammary cells via binding with estrogen receptors and/or stimulates the secretion of prolactin from the pituitary glands...
- Effects of synthetic estrogens, (R,R)-(+)-, (S,S)-(-)-, dl- and meso-hexestrol stereoisomers on microtubule assemblyY Sakakibara
Biochemistry Division, Kyoritsu College of Pharmacy, Tokyo, Japan
Biochem Pharmacol 39:167-72. 1990..These results were discussed with physico-chemical properties of hexestrols, e.g. absolute configurations as well as circular dichroism spectra and solid state carbon-13 nuclear magnetic resonance spectra...
- An assessment of estrogenic organic contaminants in Canadian wastewatersMarc P Fernandez
University of Alberta, Department of Civil and Environmental Engineering, Edmonton, AB, Canada
Sci Total Environ 373:250-69. 2007..e. dibutyl phthalate) and natural sterols (i.e. beta-sitosterol) contributing to the overall estrogenic load...
- Prevention of mammary carcinogenesis by short-term estrogen and progestin treatmentsLakshmanaswamy Rajkumar
Department of Molecular and Cell Biology and The Cancer Research Laboratory, University of California, Berkeley, California, USA
Breast Cancer Res 6:R31-7. 2004..This protective effect is observed universally among women of all ethnic groups. Parity in rats and mice also protects them against chemically induced mammary carcinogenesis...
- Impact of endocrine disrupting chemicals on reproduction in Japanese quailKrister Halldin
Department of Environmental Toxicology, Uppsala University, Norbyvagen 18A, SE 752 36 Uppsala, Sweden
Domest Anim Endocrinol 29:420-9. 2005..Our studies suggest that the neural system and the female reproductive system of avian embryos are very sensitive to the effects of chemicals with estrogenic activity...
- ERalpha gene expression in human primary osteoblasts: evidence for the expression of two receptor proteinsS Denger
European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Mol Endocrinol 15:2064-77. 2001..In particular, the current models of the action of estrogens should be reevaluated to take account of the presence of at least two ERalpha protein isoforms in bone and perhaps in other tissues...
- The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligandsR M Blair
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Toxicol Sci 54:138-53. 2000..The current study provides the most structurally diverse ER RBA data set with the widest range of RBA values published to date...
- Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1Dong yu Wang
Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario M5S 3E5, Canada
Mol Endocrinol 18:402-11. 2004..These results provide evidence that some estrogenic compounds differentially enhance the transcription of estrogen-regulated genes and suggest a role for EEIG1 in estrogen action...
- Estrogens from sewage in coastal marine environmentsShannon Atkinson
Hawaii Institute of Marine Biology, University of Hawaii at Manoa, Kaneohe, Hawaii, USA
Environ Health Perspect 111:531-5. 2003....
- Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activationKun Don Yi
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
J Pharmacol Exp Ther 324:1188-95. 2008....
- Pregnancy and lupus nephritisH Julkunen
Department of Internal Medicine, Peijas Hospital, Vantaa, Finland
Scand J Urol Nephrol 35:319-27. 2001..Especially poor fetal outcome is associated with antiphospholipid antibodies. Pregnancies in women with lupus nephritis require intense fetal and maternal surveillance...
- Induction and synchronization of estrus in dogsMichelle Anne Kutzler
158 Magruder Hall, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA
Theriogenology 64:766-75. 2005..This review will summarize published reports on estrus induction and synchronization in bitches and summarize preliminary results using a long-acting injectable preparation of deslorelin...
- Skin aging and sex hormones in women -- clinical perspectives for intervention by hormone replacement therapyPaul G Sator
Department of Dermatology, Municipal Hospital Lainz, Vienna, Austria
Exp Dermatol 13:36-40. 2004..Although a large number of publications have documented the effects of sex hormones on the aging process, it is obvious that hormone replacement should not be administered as an independent treatment for skin aging...
- Effects of environmental and natural estrogens on vitellogenin production in hepatocytes of the brown frog (Rana temporaria)T Rouhani Rankouhi
Institute for Risk Assessment Sciences IRAS, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands
Aquat Toxicol 71:97-101. 2005..Exposure to bisphenol A and methoxychlor concentrations up to 100 microM did not have any effect on in vitro vitellogenesis...
- Early exposure to genistein exerts long-lasting effects on the endocrine and immune systems in ratsSabra L Klein
The W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Mol Med 8:742-9. 2002..The primary goal of this study was to compare the effects of perinatal exposure with life-long exposure to genistein, an estrogenic compound in soy, on the endocrine and immune system in adulthood...
- Effects of phytoestrogens on the ovarian and pituitary phenotypes of estrogen-deficient female aromatase knockout miceKara L Britt
Prince Henry s Institute of Medical Research, Monash University, Clayton, Victoria, Australia
Menopause 12:174-85. 2005..The purpose of this study was to evaluate the (ArKO) mouse as a model to test the effects of phytoestrogen replacement in vivo...
- Regulation of NFkappaB activity by the Estrogen ReceptorKendall W Nettles; Fiscal Year: 2012..We propose to use these synthetic compounds to understand the molecular details of this important anti-inflammatory pathway. ..
- Effect of bisphenol A exposure on mammary stem cell function and transformationLuzhe Sun; Fiscal Year: 2013....
- Actions of Endoxifen on the SkeletonAnne Gingery; Fiscal Year: 2013....
- Molecular Complementation of Nuclear ReceptorsJohn T Koh; Fiscal Year: 2010..We will further develop these "functionally orthogonal" estrogen/ER pairs as novel chemical biology tools for dissecting the seven or more estrogen dependent signaling pathways. ..
- A Molecular Basis for Phytoestrogen ChemopreventionAndrew Mesecar; Fiscal Year: 2002..aid in the design of new compounds that can serve as selective estrogen modulators (SERMs). ..
- MOLECULAR BASIS OF SEX STEROID ACTION IN PROSTATE CANCERYuan Shan Zhu; Fiscal Year: 2005..abstract_text> ..
- Effects of dietary phytoestrogens on the aging brainCynthia Corbitt; Fiscal Year: 2006..For specific aim 2, end points include morphological measures (size of infarct) and number of cells with ischemia-induced damage in regions surrounding the infarct. ..
- Estrogen enhancement of endothelial vasodilatory factorsRoshanak Rahimian; Fiscal Year: 2003..The enhanced insight into these protective mechanisms is expected to eventually also be beneficial for the male population. ..
- LIGAND/PROTEIN INTERACTIONS IN ESTROGEN RECEPTORSRichard Miksicek; Fiscal Year: 1993....
- MULTISTAGE CARCINOGENESIS OF THE CERVIX AND VAGINAClaudio Conti; Fiscal Year: 1992..The effect of ovarian hormones on these genetic altered cultures will be evaluated in short term and long term experiments in vivo and in vitro...
- Zebrafish Assay for Identifying Endocrine DisruptorsCatherine Willett; Fiscal Year: 2004..Zebra fish are also inexpensive to breed and maintain, and large numbers can be analyzed for statistically significant results. ..
- Estrogen Pathway Genes and Association with Prostate Cancer RiskJanet Stanford; Fiscal Year: 2009..In addition, this study may identify patient characteristics that interplay with genotypes to increase risk. Lastly, results may serve as pilot data to further explore novel estrogen or anti-estrogen therapeutic approaches. ..
- BIOSENSOR STUDIES OF ESTROGENIC COMPOUNDS WITH HER-A & BRichard Smith; Fiscal Year: 1999..This research will provide data which defines the scope of application of the instrument. ..
- ESTROGEN IMPRINTING OF PROSTATE GLAND VIA METHYLATONGail Prins; Fiscal Year: 2005....
- A MECHANISTIC BIOASSAY FOR EPIGENETIC CARCINOGENSCatherine Klein; Fiscal Year: 2002..The long term goals of this project are to further validate the use of the Epigene Assay for routine experimental and risk assessment used, as well as for mechanistic studies of altered DNA methylation and gene expression. ..
- LIGAND STRUCTURE AND ER MEDIATED TRANSACTIVATIONJANICE SCHWARTZ; Fiscal Year: 2002....
- SYNTHESIS AND BIOLOGIC ACTIVITY OF NOVEL PHYTOESTROGENSSARA LI; Fiscal Year: 1992..One unique advantage of biologic estrogenic activity available to this group is the use of a specific estrogen-induced primary epithelial cell proliferation system to screen potentially useful compounds...
- MOLECULAR ORIGIN OF CANCER--CATECHOL/SEMIQUINOE/QUINONEErcole Cavalieri; Fiscal Year: 2003..In addition, we will identify biomarkers for use in diagnosis and in studies of prevention of breast cancer and other diseases. ..
- Molecular Orgin Cancer--Catechol Estrogen 3 4 QuinonesErcole Cavalieri; Fiscal Year: 2004..The knowledge acquired from these studies will be essential for developing preventive strategies. ..
- Coactivation of Estrogen Receptor alpha/Sp1Stephen Safe; Fiscal Year: 2006..abstract_text> ..
- Colon Cancer Inhibition by a Class of PPARgamma AgonistsStephen Safe; Fiscal Year: 2009..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2007..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- Mechanisms of Growth Factor-Estrogen Receptor CrosstalkStephen Safe; Fiscal Year: 2006..abstract_text> ..
- Vascular Protective Role of Endothelin B ReceptorsRAOUF KHALIL; Fiscal Year: 2006..abstract_text> ..
- Estrogens for Alcoholism & Its Neurological ConsequencesJames Simpkins; Fiscal Year: 2008..the proposed studies will provide new knowledge on the mechanism of estrogen protection from the consequences of EW and determine if estrogens are potential pharmacotherapies for alcoholism and its consequences [unreadable] [unreadable]..
- Inhibition of Pancreatic Cancer by New PPARgamma Agonis*Stephen Safe; Fiscal Year: 2008..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
- 2,3,7,8,--TCDD Effects on the Estrogenic ResponsesStephen Safe; Fiscal Year: 2006..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
- ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXESStephen Safe; Fiscal Year: 2002..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
- ALKYL PCDFS--INHIBITION OF MAMMARY CANCERStephen Safe; Fiscal Year: 2001..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
- EXERCISE, DIET, AND SEX HORMONES IN POSTMENOPAUSAL WOMENAnne McTiernan; Fiscal Year: 2008..Intervention adherence will be monitored via exercise and diet logs and weekly weighing. Potential adverse effects will be measured including injuries, overall bone density (DEXA), and Quality of Life. ..
- ENVIRONMENTAL INFLUENCES ON BRAIN PLASTICITYDavid Crews; Fiscal Year: 2002..The final category of experiments is particularly important as it will discern whether the incubation temperature effects are direct or indirect. ..
- Pittsburgh Mind-Body Center-IIKaren Matthews; Fiscal Year: 2008..Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible. ..
- EVOLUTION OF BRAIN-BEHAVIOR CONTROLLING MECHANISMSDavid Crews; Fiscal Year: 2009..abstract_text> ..
- BRAIN TARGETING OF THYROTROPIN RELEASING HORMONE ANALOGSLaszlo Prokai; Fiscal Year: 2002..Behavioral observations, dose-dependence and duration of action will also be addressed by appropriate method or study designs. ..
- The Role of GPR30 in Advanced Endometrial CancerEric Prossnitz; Fiscal Year: 2009..abstract_text> ..
- The Role of Quinols in Estrogen NeuroprotectionLaszlo Prokai; Fiscal Year: 2006..Hence, they will serve as new lead compounds for the development of neuroprotective agents with improved efficacy. ..
- EFFECT OF RALOXIFENE ON SALIVARY STEROIDSVIRGIL JORDAN; Fiscal Year: 2002..Most importantly, completion of the study will validate an important new methodology to monitor the ovarian effects of any new chemopreventive that can be used in premenopausal women. ..
- Timing of dietary exposure and breast cancer riskLeena Hilakivi Clarke; Fiscal Year: 2008..This program aims to develop novel means to prevent some breast cancers by dietary modifications that take place during pregnancy and puberty. ..
- A novel intracellular 7TM estrogen receptor in breastEric R Prossnitz; Fiscal Year: 2010..abstract_text> ..
- MECHANISMS OF LEUKOCYTE ACTIVATION AND CHEMOTAXISEric Prossnitz; Fiscal Year: 2002....
- NONHISTONE PROTEINS AND HORMONAL CARCINOGENESISDeodutta Roy; Fiscal Year: 2001....
- Pharmacogenetics of Sulfate ConjugationVIRGIL JORDAN; Fiscal Year: 2006..These results will increase our understanding of the contribution of SULT1A1 pharmacogenetics to individual variation in response to estrogens and an important antiestrogen. ..
- TRAINING PROGRAM IN NEUROBIOLOGY AND BEHAVIORDavid Crews; Fiscal Year: 2003..All of the laboratories comply with NIH requirements. ..
- The Yoga for Hyperkyphosis TrialGail Greendale; Fiscal Year: 2007..At the end of this phase we will again measure study endpoints to assess whether participants have maintained the physical function achieved at the end of the RCT. ..
- Pregnancy Estrogens, Diet, and Breast Cancer RiskLeena Hilakivi Clarke; Fiscal Year: 2005..abstract_text> ..
- Cellular and Molecular Mediators of Hantavirus InfectionSabra Klein; Fiscal Year: 2006..abstract_text> ..
- Melanoma PathogenesisLinda Titus Ernstoff; Fiscal Year: 2006..e., slide preparation) of pathology specimens, and the refinement of laboratory techniques for analyzing chromosome 9p21 alterations. [unreadable] [unreadable]..
- PERINATAL ESTROGEN, OXIDATIVE DAMAGES & UTERINE LESIONSDeodutta Roy; Fiscal Year: 2005....
- Epigenetic Influences on Brain and BehaviorDavid Crews; Fiscal Year: 2004..Specific Aim III. To establish if the different behavioral profiles exhibited in such animals in adulthood are reflected in different patterns of activity in a network of interconnected limbic nuclei. ..
- EXERCISE INTERVENTION IN COLORECTAL POLYP PATIENTSAnne McTiernan; Fiscal Year: 2004..Results from this unique human experimental study will provide important information about mechanisms of exercise effects on colon carcinogenesis and about potential ..
- Molecular Consequences of Estrogen-Induced InterferonyS Ahmed; Fiscal Year: 2007..1 Description, ..
- In utero dietary exposure to endocrine disruptorsLeena Hilakivi Clarke; Fiscal Year: 2007..unreadable] [unreadable]..
- Arrestin activation probed with mass spectrometryEric Prossnitz; Fiscal Year: 2007..Our results will contribute to our basic knowledge of this key signaling molecule and provide the basis for the design of therapeutic agents related to GPCR signaling. ..
- Sex Steroids & Mammographic Density in the PostmenopauseGail Greendale; Fiscal Year: 2007..We will quantify the relations between the hormone and genetic exposures measured in this project and mammographic density (at baseline as well as change in density between baseline and 12 months). ..
- Stress, Sleep and Emerging CVD Risk FactorsKaren Matthews; Fiscal Year: 2007..The study will provide novel data testing the relationships of daytime stressful events, SDB, and other nocturnal physiological measures with the emerging risk factors and subclinical CVD measured in HeartSCORE. [unreadable] [unreadable]..
- Survey of Age-Associated Carbonylation of Brain ProteinsLaszlo Prokai; Fiscal Year: 2008..The degree of association will be determined between performance in each task and the degree of specific carbonylation associated with individual aging-associated oxidation-sensitive proteins. ..