Genomes and Genes
medroxyprogesterone 17 acetate
Summary: A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
Publications272 found, 100 shown here
- Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trialJacques E Rossouw
Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
JAMA 288:321-33. 2002..Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain...
- Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trialSally A Shumaker
Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27104, USA
JAMA 289:2651-62. 2003..On July 8, 2002, the study drugs, estrogen plus progestin, in the Women's Health Initiative (WHI) trial were discontinued because of certain increased health risks in women receiving combined hormone therapy...
- Provision of DMPA by community health workers: what the evidence showsShawn Malarcher
Office of Population and Reproductive Health, Bureau for Global Health, USAID, Washington, DC 20523 3600, USA
Contraception 83:495-503. 2011..This article synthesizes evidence on the feasibility, safety and effectiveness of community-based delivery of the injectable contraceptive depot-medroxyprogesterone acetate (DMPA)...
- Hormonal contraception and HIV acquisition: reanalysis using marginal structural modelingCharles S Morrison
Behavioral and Biomedical Research Division, Family Health International, Research Triangle Park, North Carolina 27709, USA
AIDS 24:1778-81. 2010..Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk...
- Provision of injectable contraceptives in Ethiopia through community-based reproductive health agentsNdola Prata
University of California at Berkeley, School of Public Health, 229 University Hall, Berkeley, CA 94720 6390, United States of America
Bull World Health Organ 89:556-64. 2011..To determine whether community-based health workers in a rural region of Ethiopia can provide injectable contraceptives to women with similar levels of safety, effectiveness and acceptability as health extension workers (HEWs)...
- Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in womenLudo Lavreys
Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, Washington 98104 2499, USA
J Infect Dis 189:303-11. 2004..These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection...
- Dendritic cell activation and memory cell development are impaired among mice administered medroxyprogesterone acetate prior to mucosal herpes simplex virus type 1 infectionRodolfo D Vicetti Miguel
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
J Immunol 189:3449-61. 2012..Taken together, our results reveal that the administration of MPA prior to viral infection of mucosal tissue impairs DC activation, virus-specific T cell expansion, and development of virus-specific immunological memory...
- Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trialDavid D Waters
Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
JAMA 288:2432-40. 2002..Hormone replacement therapy (HRT) and antioxidant vitamins are widely used for secondary prevention in postmenopausal women with coronary disease, but no clinical trials have demonstrated benefit to support their use...
- Hormonal contraception and the risk of HIV acquisition among women in South AfricaCharles S Morrison
FHI 360, Durham, North Carolina 27713, USA
AIDS 26:497-504. 2012....
- Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II)Deborah Grady
Department of Epidemiology and Biostatistics, University of California, San Francisco, 74 New Montgomery St, Suite 600, San Francisco, CA 94105, USA
JAMA 288:49-57. 2002..However, in the hormone group, findings did suggest a higher risk of CHD events during the first year, and a decreased risk during years 3 to 5...
- Safety and tolerability of depot medroxyprogesterone acetate among HIV-infected women on antiretroviral therapy: ACTG A5093D Heather Watts
National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
Contraception 77:84-90. 2008..We evaluated the safety and tolerability of depot medroxyprogesterone acetate (DMPA) among women on ARV...
- Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cellsDominique Koubovec
Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa
Mol Cell Endocrinol 221:75-85. 2004..The MPA-induced nuclear translocation of the glucocorticoid receptor (GR), as well as the antagonistic effects of RU486, strongly suggest that the actions of MPA in these cells are mediated at least in part via the GR...
- Hormonal contraception and HIV-1 infection: medroxyprogesterone acetate suppresses innate and adaptive immune mechanismsRichard P H Huijbregts
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
Endocrinology 154:1282-95. 2013..The presented results suggest that MPA suppresses both innate and adaptive arms of the immune system resulting in a reduction of host resistance to invading pathogens...
- Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trialStephen R Rapp
Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
JAMA 289:2663-72. 2003..On July 8, 2002, the estrogen plus progestin therapy in the WHI trial was discontinued because of certain increased health risks for women...
- Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cellsJeffrey D Bray
Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
J Steroid Biochem Mol Biol 97:328-41. 2005..This analysis demonstrates a high degree of similarity among these progestins on PR-regulated gene expression in T47D cells, suggesting a similar and fairly specific mode of action...
- A novel immortalized human endometrial stromal cell line with normal progestational responseGraciela Krikun
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, P O Box 208063, New Haven, Connecticut 06520 8063, USA
Endocrinology 145:2291-6. 2004..In summary, an immortalized HESC line has been developed that is karyotypically, morphologically, and phenotypically similar to the primary parent cells, and it is a powerful and consistent resource for in vitro work...
- 5-aza-2'-deoxycytidine improves the sensitivity of endometrial cancer cells to progesterone therapyQian Hu
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China
Int J Gynecol Cancer 22:951-9. 2012..Here, we explored whether 5-aza-2'-deoxycytidine (5-aza-CdR), a demethylating agent, could enhance the susceptibility of EC cells to medroxyprogesterone acetate (MPA)...
- Contraceptive choices, pregnancy rates, and outcomes in a microbicide trialSengeziwe Sibeko
Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
Obstet Gynecol 118:895-904. 2011....
- Scaling up community provision of injectables through the public sector in UgandaKirsten Krueger
FHI, P O Box 13950, Research Triangle Park, NC 27709, USA
Stud Fam Plann 42:117-24. 2011..Lessons from scaling up in Uganda's public sector include recognizing the needs for ongoing assessment of support, a process to gain community "ownership," and spontaneous innovations to supplement CHW supervision...
- Hormonal contraceptive use, cervical ectopy, and the acquisition of cervical infectionsCharles S Morrison
Family Health International, Research Triangle Park, North Carolina 27709, USA
Sex Transm Dis 31:561-7. 2004..Several previous studies have suggested that hormonal contraception could be associated with increased risk of cervical infections. However, few high-quality prospective studies have examined this relationship...
- Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research GroupS Hulley
University of California, San Francisco 94143, USA
JAMA 280:605-13. 1998..However, given the favorable pattern of CHD events after several years of therapy, it could be appropriate for women already receiving this treatment to continue...
- Progestin-based contraceptive suppresses cellular immune responses in SHIV-infected rhesus macaquesNataliya Trunova
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave, 7th Floor, New York, NY 10016, USA
Virology 352:169-77. 2006....
- Synthetic progestins used in HRT have different glucocorticoid agonist propertiesDominique Koubovec
Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch 7602, South Africa
Mol Cell Endocrinol 242:23-32. 2005..MPA and NET-A therefore display very different GC-like properties compared to each other and to prog, and are likely to exhibit different side effects via the GR...
- The effect of hormonal contraception on genital tract shedding of HIV-1Chia C Wang
Department of Medicine, University of Washington, Seattle, Washington 98104 2499, USA
AIDS 18:205-9. 2004..We conducted a prospective study to determine if cervical shedding of HIV-1 increased after initiating hormonal contraception...
- Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cellsCecilia Proietti
Instituto de Biología y Medicina Experimental IBYME, CONICET, Buenos Aires 1428, Argentina
Mol Cell Biol 25:4826-40. 2005..Our results have for the first time demonstrated that progestins are able to induce Stat3 transcriptional activation, which is in turn an obligatory requirement for progestin stimulation of both in vitro and in vivo breast cancer growth...
- Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized TrialRowan T Chlebowski
Harbor UCLA Research and Education Institute, Torrance 90502, USA
JAMA 289:3243-53. 2003..Outstanding issues not previously addressed include characteristics of breast cancers observed among women using hormones and whether diagnosis may be influenced by hormone effects on mammography...
- Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trialSylvia Wassertheil-Smoller
Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
JAMA 289:2673-84. 2003..The Women's Health Initiative (WHI) trial of estrogen plus progestin was stopped early because of adverse effects, including an increased risk of stroke in the estrogen plus progestin group...
- Hormonal contraceptive use and HIV disease progression among women in Uganda and ZimbabweCharles S Morrison
Department of Clinical Sciences, Family Health International, Research Triangle Park, NC, USA
J Acquir Immune Defic Syndr 57:157-64. 2011..Previous studies report conflicting results regarding the effect of hormonal contraception on HIV disease progression...
- Potential role of leptin expression in hepatocellular carcinomaS N Wang
Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
J Clin Pathol 59:930-4. 2006..Obesity is associated with hepatocellular carcinoma (HCC). The association may result from the aberrant expression of adipokines...
- Pharmacological and endogenous progestins induce vascular endothelial growth factor expression in human breast cancer cellsS M Hyder
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center Houston, Houston, TX 77030, USA
Int J Cancer 92:469-73. 2001..This report demonstrates that progestins stimulate VEGF mRNA levels and raises the possibility that anti-progestins may be useful to inhibit proliferation and metastasis in some human breast cancers by blocking VEGF production...
- Interleukin-2, interferon-alpha and medroxyprogesterone acetate in metastatic renal cell carcinomaEmanuele Naglieri
Medical and Experimental Oncology Department, Oncology Institute, Via Amendola 209, 70126 Bari, Italy
Anticancer Res 22:3045-51. 2002..Therefore the purpose of our study was to evaluate the toxicity and the efficacy of the association between IL-2, IFN-alpha and MPA...
- Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II)Stephen Hulley
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143 0560, USA
JAMA 288:58-66. 2002..The Heart and Estrogen/progestin Replacement Study (HERS) was a randomized trial of estrogen plus progestin therapy after menopause...
- Effect of postmenopausal hormones on inflammation-sensitive proteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) StudyM Cushman
Departments of Medicine, and Biochemistry, University of Vermont, Burlington, VT 05446, USA
Circulation 100:717-22. 1999..Because higher levels of inflammation factors predict vascular disease outcomes, the effect of hormones on these factors is of interest...
- Characterization of a novel telomerase-immortalized human endometrial stromal cell line, St-T1bAnnemarie Samalecos
Endokrinologikum Hamburg, 20251 Hamburg, Germany
Reprod Biol Endocrinol 7:76. 2009..Studies into the mechanisms of decidualization are often hampered by the lack of primary ESC. Here we describe a novel immortalized human ESC line...
- Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetateGrant Buchanan
Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide Hanson Institute, Adelaide, South Australia, Australia
Cancer Res 65:8487-96. 2005..Collectively, these data suggest that reduced levels of AR or impaired AR function contribute to the failure of MPA therapy potentially due to abrogation of the inhibitory effect of AR on ER signaling...
- Estrogen and progestin, lipoprotein(a), and the risk of recurrent coronary heart disease events after menopauseM G Shlipak
Department of Medicine, University of California, and Veterans Affairs Medical Center, San Francisco, USA
JAMA 283:1845-52. 2000..However, few data exist on the clinical importance of Lp(a) lowering for CHD prevention. Hormone therapy with estrogen has been found to lower Lp(a) levels in women...
- Hormonal contraception and HIV prevalence in four African countriesPauline M Leclerc
Epidemiologie des Maladies Emergentes, Institut Pasteur, 25 rue du Docteur Roux, Paris, France
Contraception 77:371-6. 2008..The HIV seroprevalence among women aged 15-24 years was compared according to their pattern of contraceptive use in four African countries: Kenya, Lesotho, Malawi and Zimbabwe...
- Abrogation of attenuated lentivirus-induced protection in rhesus macaques by administration of depo-provera before intravaginal challenge with simian immunodeficiency virus mac239Kristina Abel
Center for Comparative Medicine, and California National Primate Research Center, University of California at Davis, Davis, California 95616, USA
J Infect Dis 190:1697-705. 2004..6-immunized macaques. In the primate model of sexual transmission of human immunodeficiency virus, treatment with progesterone before IVAG challenge with a pathogenic virus can decrease the efficacy of a model "vaccine."..
- Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signalingJon Nilsen
Department of Molecular Pharmacology and Toxicology and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90089, USA
Proc Natl Acad Sci U S A 100:10506-11. 2003..The recent results from the Women's Health Initiative trial, which used MPA as the progestinal agent, indicate that differences between progestin formulations are crucial to health outcomes in women...
- Effect of hormone replacement therapy on lipoprotein(a) and lipid levels in postmenopausal women. Influence of various progestogens and duration of therapyC J Kim
Department of Internal Medicine, Chung Ang University Medical Center, Seoul, Korea
Arch Intern Med 156:1693-700. 1996..One of the possible mechanisms of this effect is the modification of lipid profiles. However, there is controversy concerning the effects on lipoprotein(a) [Lp (a)] and lipid levels of progestogens administered with estrogen...
- Medroxyprogesterone acetate antagonizes the effects of estrogen treatment on social and sexual behavior in female macaquesKaren Pazol
Yerkes National Primate Research Center and the Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
J Clin Endocrinol Metab 89:2998-3006. 2004..The marked increase in aggression seen during MPA treatment suggests that production of negative affect may be a particularly serious side effect of MPA...
- A prospective, one-year study on the effects of two long acting injectable contraceptives (depot-medroxyprogesterone acetate and norethisterone oenanthate) on serum and lipoprotein lipidsL Enk
Department of Obstetrics and Gynecology, Sahlgrenska Hospital, , Sweden
Horm Metab Res 24:85-9. 1992..Thus our findings might indicate an adverse effect in this respect of long term treatment with these progestins, particularly with NET...
- Incidence of sexually transmitted infections among HIV-infected women using depot medroxyprogesterone acetate contraceptionEdgar Turner Overton
Division of Infectious Diseases, Washington University School of Medicine, Campus Box 8051, St Louis, MO 63110 1093, USA
Contraception 78:125-30. 2008..The primary aim of this study was to characterize the potential association between DMPA use and risk of STI acquisition among HIV-infected women...
- Use of injectable progestin contraception and risk of STI among South African womenAudrey Pettifor
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Contraception 80:555-60. 2009....
- Inhibition of cAMP-mediated decidualization in human endometrial stromal cells by IL-1beta and lamininK Mizuno
Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan
Horm Metab Res 31:307-10. 1999..These results indicate that IL-1beta and laminin additively and mutually inhibit cAMP-mediated decidualization signals, and that they may inhibit these signals through different mechanisms...
- Progesterone increases susceptibility and decreases immune responses to genital herpes infectionCharu Kaushic
Department of Pathology and Molecular Medicine, Center of Gene Therapeutics, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
J Virol 77:4558-65. 2003..Animal models and vaccine strategies for sexually transmitted diseases need to consider the effect of hormone treatments on susceptibility and immune responses...
- Oxidative stress, lipid profile and liver functions in average Egyptian long term depo medroxy progesterone acetate (DMPA) usersL M Faddah
Biochemistry Departments, Faculty of Pharmacy, El Minia University, Egypt
Molecules 10:1145-52. 2005..In addition, annual re-evaluation is much more advisable despite the proven safety of the drug...
- Estrogen plus progestin and the risk of coronary heart diseaseJoAnn E Manson
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
N Engl J Med 349:523-34. 2003..In this report, we provide the final results with regard to estrogen plus progestin and CHD from the Women's Health Initiative (WHI)...
- Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase/Akt/nuclear factor-kappaB cascade in human breast cancer cellsMaki Saitoh
Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
Endocrinology 146:4917-25. 2005....
- Treatment adherence in the Estonian postmenopausal hormone therapy (EPHT) trial [ISRCTN35338757]Sigrid Vorobjov
Department of Epidemiology and Biostatistics, National Institute for Health Development, Hiiu 42, 11619 Tallinn, Estonia
Maturitas 52:286-95. 2005..To investigate treatment adherence and factors related to non-adherence in the Estonian postmenopausal hormone therapy (EPHT) trial...
- Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health InitiativeVanessa M Barnabei
Department of Obstetrics and Gynecology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
Obstet Gynecol 105:1063-73. 2005..To estimate the effects of estrogen plus progestin (E+P) therapy on menopausal symptoms, vaginal bleeding, gynecologic surgery rates, and treatment-related adverse effects in postmenopausal women...
- Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cellsTommaso Simoncini
Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa 56100, Italy
Endocrinology 145:5745-56. 2004..Our findings show significant differences in the signal transduction pathways recruited by P and MPA in endothelial cells, which may have relevant clinical implications...
- Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt's lymphoma cells and cell lines: potential for applying old drugs to a new diseaseS L Fenton
Division of Medical Sciences, University of Birmingham, UK
Leukemia 17:568-75. 2003..Importantly, since fibrates and MPA are inexpensive and stable with minimal-associated toxicities, we suggest that these drugs should be considered as adjuncts to currently available treatments for BL in endemic and AIDS-related disease...
- Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy: results from the Heart and Estrogen/Progestin Replacement Study (HERS) trialMark A Hlatky
Stanford University School of Medicine, HRP Redwood Bldg, Room 150, Stanford, CA 94305 5405, USA
JAMA 287:591-7. 2002..Postmenopausal hormone therapy is commonly used by women for disease prevention, but its effects on quality of life have not been well documented...
- Spinal bone density in women using depot medroxyprogesterone contraceptionT Cundy
Department of Medicine, The Faculty of Medicine and Health Sciences, University of Auckland, New Zealand
Obstet Gynecol 92:569-73. 1998..To determine factors possibly associated with reduced bone density in women using the injectable contraceptive depot medroxyprogesterone acetate...
- Progestin-induced caveolin-1 expression mediates breast cancer cell proliferationM Salatino
Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
Oncogene 25:7723-39. 2006..We also demonstrated that caveolin-1 is a downstream effector of MPA that is partially responsible for the stimulation of growth of breast cancer cells...
- Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2R E Hayden
University of Birmingham, School of Biosciences, Edgbaston, Birmingham, UK
Leukemia 23:292-304. 2009..Given the known safety profiles of BEZ and MPA, our data warrant further investigation of their potential as novel therapy for CLL...
- Progesterone receptor regulates decidual prolactin expression in differentiating human endometrial stromal cellsJ J Brosens
Department of Reproductive Sciences and Medicine, Imperial College of Science, Technology, and Medicine, Hammersmith Hospital, London, United Kingdom
Endocrinology 140:4809-20. 1999....
- Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosisM R Adams
Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27157 1040, USA
Arterioscler Thromb Vasc Biol 17:217-21. 1997..Although the mechanism(s) remains unclear, we conclude that oral CEE inhibits the initiation and progression of coronary artery atherosclerosis and that continuously administered oral MPA antagonizes this atheroprotective effect...
- Overview of why hormones may be an issueChristine Mauck
CONRAD Arlington, VA, USA
J Acquir Immune Defic Syndr 38:S11-2. 2005
- Depo medroxyprogesterone acetate (DMPA) and combined oral contraceptives and cervical carcinoma in-situ in women aged 50 years and underC Hoyo
Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
West Indian Med J 53:406-12. 2004..4, 95% CI: 0.7, 3.1). These results suggest that if hormonal contraceptive use confers any risk of CIS, it is confined to long-term users. Increased risk in some groups, however, warrant further study...
- Dissociative glucocorticoid activity of medroxyprogesterone acetate in normal human lymphocytesC M Bamberger
Department of Medicine, University Hospital Eppendorf, Hamburg, Germany
J Clin Endocrinol Metab 84:4055-61. 1999..Because of its dissociative GC activity, MPA is a highly promising substance for the treatment of inflammatory/autoimmune states...
- Involvement of EGF in medroxyprogesterone acetate (MPA)-induced mammary gland hyperplasia and its role in MPA-induced mammary tumors in BALB/c miceA Molinolo
Instituto de Biologia y Medicina Experimental, Academia Nacional de Medicina, Buenos Aires, Argentina
Cancer Lett 126:49-57. 1998..It can be concluded that although EGF plays an important role in MPA-induced mammary carcinogenesis, it is not necessary in PD tumor growth...
- Ligand- and cell-specific effects of signal transduction pathway inhibitors on progestin-induced vascular endothelial growth factor levels in human breast cancer cellsJianbo Wu
Dalton Cardiovascular Research Center and the Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
Mol Endocrinol 19:312-26. 2005....
- The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cellsRadhika P Ghatge
University of Colorado Health Sciences Center, Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, Denver, Colorado, USA
Breast Cancer Res 7:R1036-50. 2005..Is this risk due to its progestational or androgenic properties? To address this, we assessed the transcriptional effects of MPA as compared with those of progesterone and dihydrotestosterone (DHT) in human breast cancer cells...
- Depo-Provera abrogates attenuated lentivirus-induced protection in male rhesus macaques challenged intravenously with pathogenic SIVmac239Meritxell Genesca
Center for Comparative Medicine, University of California, Davis, CA 95616, USA
J Med Primatol 36:266-75. 2007..Progesterone administration prior to intravaginal challenge with pathogenic SIVmac239 decreases the protective efficacy of live attenuated vaccines in rhesus macaques...
- Medroxyprogesterone acetate binds the glucocorticoid receptor to stimulate alpha-ENaC and sgk1 expression in renal collecting duct epitheliaChristie P Thomas
Division of Nephrology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1081, USA
Am J Physiol Renal Physiol 290:F306-12. 2006..The activation of steroid receptors such as GR can explain the apparent glucocorticoid effects of MPA, independent of PR activation...
- Prospective study of hormonal contraception and women's risk of HIV infection in South AfricaLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
Int J Epidemiol 36:166-74. 2007..We investigated associations between HIV incidence and use of combined oral contraceptives (COC), norethindrone enanthate (NET-EN) or depot medroxyprogesterone acetate (DMPA) in a cohort of South African women...
- Effects of long-term HRT and tamoxifen on the expression of progesterone receptors A and B in breast tissue from surgically postmenopausal cynomolgus macaquesE Isaksson
Department of Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden
Breast Cancer Res Treat 79:233-9. 2003..The results suggest that hormonal treatments have a different influence on the PRA/PRB balance in the breast...
- Adjuvant high-dose medroxyprogesterone acetate for early breast cancer: 13 years update in a multicentre randomized trialC Focan
Br J Cancer 85:1-8. 2001..For both NN and NP patients, differences in overall survivals observed in older women with a shorter follow-up, were no longer detected...
- The effects of progesterone, medroxyprogesterone acetate, and norethisterone on growth factor- and estradiol-treated human cancerous and noncancerous breast cellsElizabeth A Krämer
Section of Endocrinology and Menopause, University Womens Hospital, Tuebingen, Germany
Menopause 12:468-74. 2005....
- Effects of conjugated estrogens, medroxyprogesterone acetate, and tamoxifen on the mammary glands of macaquesJ M Cline
Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina 27157 1040, USA
Breast Cancer Res Treat 48:221-9. 1998....
- Relationship between progesterone receptor level in endometrium and bleeding pattern in depot medroxyprogesterone acetate usersPichai Chotnopparatpattara
Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
J Med Assoc Thai 86:172-7. 2003..05). In conclusion, after a second dose of DMPA, subjects with amenorrhea had a higher stromal PR score than those with uterine bleeding...
- Regulation of progesterone receptor messenger ribonucleic acid by progestin in human endometrial stromal cellsL Tseng
Department of Obstetrics, Gynecology and Reproductive Medicine, State University of New York at Stony Brook, 11794, USA
Biol Reprod 57:1360-6. 1997..The up-regulation of PR by progestin may be mediated in part by progestin-induced endometrial stromal cell factors such as estrogen and insulin-like growth factor-I, both of which stimulated the PR-A and PR-B mRNA in stromal cells...
- [Effects of hormonal replacement therapy on breast density in postmenopausal women]T Bisanti
Dipartimento di Scienze Ginecologiche, Perinatologia, Puericultura, Universita degli Studi di Roma La Sapienza, Roma, Italy
Minerva Ginecol 56:125-30. 2004..The aim of this non randomised prospective study was to evaluate the effects of HRT and Tibolone on breast density in postmenopausal women...
- Combination therapy of low-dose medroxyprogesterone acetate and oral estrogen does not affect endothelial function in the forearms of postmenopausal womenMitsuhiro Sanada
Department of Obstetrics and Gynecology, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
Menopause 9:360-6. 2002..We investigated whether low-dose medroxyprogesterone acetate (MPA) combined with oral estrogen had adverse effects on endothelial function compared with oral estrogen alone in postmenopausal women with mild hypercholesterolemia...
- Comparison of the effects of tibolone and estrogen replacement therapy on echocardiographic basic cardiac functions in post-menopausal women: a randomized placebo controlled studyOmur Taskin
Department of Obstetrics Gynecology, Division of Reprod Endoc, Akdeniz University School of Medicine, Antalya, Turkey
Maturitas 48:354-9. 2004..This study is designed to investigate and compare the effects of synthetic steroid tibolone and HRT on systolic and diastolic heart functions in post-menopausal women...
- B-type natriuretic peptide after hormone therapy in postmenopausal women with chest pain and normal coronary angiogramHiroaki Kawano
Department of Cardiovascular Medicine, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
Menopause 15:352-6. 2008..We sought to examine the effects of hormone therapy (HT) on myocardial function and cardiac natriuretic peptides in postmenopausal women with chest pain and a normal coronary angiogram...
- Estrogen replacement therapy among postmenopausal women and its effects on signs and symptoms of temporomandibular disordersAysen Nekora-Azak
University of Istanbul, Faculty of Dentistry, Department of Maxillofacial Prosthodontics, Istanbul, Turkey
Cranio 26:211-5. 2008..There was no association between the use of postmenopausal hormones and the signs and symptoms of TMD in this study...
- No increased risk of endometrial hyperplasia with fixed long-cycle oestrogen-progestogen therapy after five yearsRisto Erkkola
Turku University Hospital, Turku, Finland
J Br Menopause Soc 10:9-13. 2004..Mammography was performed at baseline and at 24-month intervals thereafter. Adverse events were assessed throughout the study...
- [Differential effects on serum IGF-1 of tibolone (5 mg/day) vs combined continuous estrogen/progestagen in post menopausal women]Arnaldo Porcile
Departamentos de Obstetricia y Ginecología y de Medicina, Facultad de Medicina Campus Oriente, Universidad de Chile, Santiago, Chile
Rev Med Chil 131:1151-6. 2003..Tibolone has estrogenic, androgenic and progestational effects and is used in post menopausal women. It apparently has weaker effects on endometrial proliferation and mammary stimulation than conventional hormone replacement therapy...
- Hormone therapy and ophthalmic artery blood flow changes in women with primary open-angle glaucomaCesare Battaglia
III Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy
Menopause 11:69-77. 2004..To compare the effects of hormone therapy (HT) on plasma viscosity and Doppler flow parameters in normal, healthy, postmenopausal women and in women with normal-tension and chronic, open-angle glaucoma...
- Raloxifene reduces procarboxypeptidase U, an antifibrinolytic marker. A 2-year randomized, placebo-controlled study in healthy early postmenopausal womenTatjana E Vogelvang
project Aging Women and the Institute for Cardiovascular Research Vrije Universiteit ICaR VU Department of Obstetrics and Gynecology, Vrije University Medical Center, Amsterdam, The Netherlands
Menopause 11:110-5. 2004..The aim of this study was to compare the long-term effects of two dosages of raloxifene with oral hormone therapy (HT; conjugated equine estrogens combined with medroxyprogesterone acetate) on procarboxypeptidase U...
- Effect of postmenopausal hormone replacement therapy on cardiovascular performanceKurtulus Ozdemir
Cardiology Department, Medical Faculty, Selcuk University, Aybüke Sitesi 83 14, 42080 Selçuklu, Konya, Turkey
Maturitas 47:107-13. 2004..This study was planned to investigate the long-term effects of HRT on cardiac functions and exercise performance...
- HT and WHI: the baby and the bathwaterF W Danby
Climacteric 7:112. 2004
- Modulation by progestogens of the effects of oestrogen on hepatic endocrine function in postmenopausal womenAilish G Nugent
Garvan Institute of Medical Research, Department of Endocrinology, St Vincent s Hospital, Darlinghurst, NSW, Australia
Clin Endocrinol (Oxf) 59:690-8. 2003..As progestogens attenuate the effects of oestrogen on circulating lipid levels according to their androgenic properties, we have investigated the impact of progestogen types on the hepatic endocrine effects of oestrogen...
- Progestins initiate adverse events of menopausal estrogen therapyT Thomas
College of Medicine, University of South Florida, Tampa, Florida 34677, USA
Climacteric 6:293-301. 2003..We investigated the role of synthetic progestins in initiating the adverse events associated with estrogen therapy...
- Effect of hormone replacement therapy on serum levels of tumor markers in healthy postmenopausal womenBora Cengiz
Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey
Maturitas 46:301-6. 2003..The effect of hormone replacement therapy (HRT) on serum levels of tumor markers is barely defined. The aim of this study was to evaluate the effect of HRT on levels of tumor markers CA 125, CA 15-3, CA 19-9, CEA and alpha-FP...
- Endometrial safety and tolerability of triphasic sequential hormone replacement estradiol valerate/medroxyprogesterone acetate therapy regimenM C P Rees
Nuffield Department of Obstetrics and Gynaecology, Women s Centre, John Radcliffe Hospital, Oxford, UK
Climacteric 7:23-32. 2004..Two randomized comparative multicenter studies were conducted to establish the endometrial safety and tolerability of a triphasic sequential hormone replacement estradiol valerate/medroxyprogesterone acetate (E2V/MPA) therapy regimen...
- Ultrastructure study of postmenopausal endometria of tibolone, conjugated estrogen + medroxyprogesterone acetate and tamoxifen usersTuncay Nas
Department of Obstetrics and Gynecology, Faculty of Medicine, Gazi University, 06510 Besevler, Ankara, Turkey
Saudi Med J 28:1917-9. 2007
- A low-dose start in hormone replacement therapy provides a beneficial bleeding profile and few side-effects: randomized comparison with a conventional-dose regimenL A Mattsson
Sahlgrenska University Hospital, Department of Obstetrics and Gynecology, Gothenburg, Sweden
Climacteric 7:59-69. 2004..To compare bleeding control, efficacy and safety of two dose-ranging continuous combined hormone replacement therapy (HRT) regimens with those of a conventional continuous combined HRT...
- Serum androgen levels and insulin resistance in postmenopausal women: association with hormone therapy, tibolone and raloxifeneG Christodoulakos
2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, V Sofias 76, GR 11528, Athens, Greece
Maturitas 50:321-30. 2005..To assess endogenous androgen and insulin resistance status in postmenopausal women receiving continuous combined hormone therapy (HT), tibolone, raloxifene or no therapy...
- Association of serum complement (C3, C4) and immunoglobulin (IgG, IgM) levels with hormone replacement therapy in healthy post-menopausal womenMehmet Yilmazer
Department of Obstetrics and Gynecology, Afyon Kocatepe University, Faculty of Medicine, Afyon, Turkey
Hum Reprod 18:1531-5. 2003..In this cross-sectional study, serum C3, C4, IgG and IgM levels were evaluated in healthy post-menopausal women receiving two different short-term HRT regimens, and in untreated women...
- [Profiles of irregular bleeding induced by low-dose hormone therapy and Chinese formulated herbs products]Shao Hai Wang
Department of Obstetrics and Gynecology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:256-61. 2006..To compare profiles and related factors of irregular bleeding induced by different types of low-dose hormone therapy (HT) and a Chinese formulated herbs products...
- Overweight and effect of hormone replacement therapy on lipid profiles in postmenopausal womenHong Sook Ko
Department of Internal Medicine, College of Medicine, Chung Ang University Seoul, Korea
Korean J Intern Med 20:33-9. 2005..However, the results of randomized controlled trials have been discouraging. We attempted to evaluate the influence of overweight, a frequent risk factor for coronary artery disease, on the lipid-modifying effects of HRT...
- Apoptosis and proliferation in breast cancer cells, cultured in vitro: effects of SERMsH M J Werner
Departments of Obstetrics and Gynecology, Medisch Spectrum Twente Hospital Group, Enschede, The Netherlands
Climacteric 8:294-9. 2005..e. MCF-7 and T-47D) and -negative (ER-) (i.e. MDA-MB-231) human breast cancer cells in vitro...
- The effect of postmenopausal hormone therapy with or without folic acid supplementation on serum homocysteine levelA Toprak
Department of Cardiology, Marmara University School of Medicine, Istanbul, Turkey
Climacteric 8:279-86. 2005..Additionally, a non-randomized control group with no treatment was included...
- Hormone use and patient concerns after the findings of the Women's Health InitiativeSharon J Rolnick
HealthPartners Research Foundation, Minneapolis, MN 55440 1524, USA
Menopause 12:399-404. 2005..To assess behaviors and concerns related to hormone therapy after the findings of the Women's Health Initiative (WHI)...
- Effects of two different regimens of continuous hormone replacement therapy on endometrial histopathology and postmenopausal uterine bleedingGazi Yildirim
Zeynep Kamil Women and Children s Education and Research Hospital, Istanbul, Turkey
Arch Gynecol Obstet 273:268-73. 2006..625 mg conjugated equine estrogen (CEE) + 2.5 mg medroxyprogesterone acetate (MPA) and 1 mg 17beta estradiol (E2) + 0.5 mg norethindrone acetate (NETA), on endometrial histopathology and postmenopausal uterine bleeding...
- Interleukin-6 and flow-mediated dilatation as markers of increased vascular inflammation in women receiving hormone therapyCristiana Vitale
Cardiovascular Research Unit Department of Medical Sciences, Fondazione San Raffaele IRCCS Roma, Tosinvest Sanita, Roma, Italy
Menopause 12:552-8. 2005....
- Progestogens: effects on clinical and biochemical parameters in postmenopausal womenDavid F Archer
Menopause 12:484-7. 2005
- Innate immunity predictors of HIV: the role of contraception, pregnancy and HSV-2Charles Morrison; Fiscal Year: 2013..This research provides a unique opportunity to elucidate and validate the complex associations between endogenous and exogenous hormones, HSV-2 and HIV-1 through analysis of underlying shared biological mechanisms. ..
- Variations in Hormones During Menopause: Effects on Cognitive and Brain AgingHeather A Bimonte-Nelson; Fiscal Year: 2013..This work will yield insight into cognitive effects of the menopause transition, variations in menopause type and HTs, and related mechanisms. ..
- Biosignature of the endometrium in women with endometriosisNeil Sidell; Fiscal Year: 2010....
- MOLECULAR MECHANISM OF LEIOMYOMA GROWTH AND REGRESSIONGREGORY SCOTT SCHULTZ; Fiscal Year: 2011..This proposal will investigate how fibroids are developed and grow, and ways to prevent them, including their symptoms. ..
- Quantification of Immune Cells in Women Using ContraceptionSHARON LYNELLE ACHILLES; Fiscal Year: 2013....
- A Randomized Trial of the Copper IUD versus DMPA for HIV Prevention in WomenHelen Rees; Fiscal Year: 2012....
- Factors That Affect Endometrial Immunity: Implications for HIV InfectionJoseph C Chen; Fiscal Year: 2012..The achievement of these goals can greatly contribute to the field of reproductive biology and overall reproductive health. ..
- Modulation of Hormonal and Systemic Immunity by Hormonal Contraceptive UseThomas L Cherpes; Fiscal Year: 2013....
- Effect of sex hormones on HIV infection of cervical and rectal mucosal tissueNatalia Teleshova; Fiscal Year: 2013..Furthermore, we will address the mechanism of progestin/progesterone action at both sites by focusing on the immune environment and potentially identify underlying factors that influence a woman's susceptibility to HIV infection. ..
- Evaluation of the immunologic and genital tract changes among Malawian women Jennifer Tang; Fiscal Year: 2013..This trial will be submitted by Dr. Tang as an R01 application before the end of the 4-year career development award period. ..
- Evaluation of a subunit Chlamydia trachomatis vaccine in Rhesus MacaquesLuis M de la Maza; Fiscal Year: 2011..vag. challenge. Decreasing the incidence and prevalence of CT infections with a vaccine would have a major health impact worldwide. ..
- Hormone Therapy and Cognitive Aging in Older and Younger Postmenopausal Women: ESally Shumaker; Fiscal Year: 2011..WHIMS-Y tests the [unreadable]window of opportunity[unreadable] hypothesis that HT shortly after menopause will confer benefit to later cognitive health. ..
- The effect of Depo-Provera on HIV susceptibility, immune activation, and PrEP PKCRAIG WALTER HENDRIX; Fiscal Year: 2013....
- Hormonal Contraception and HIV Acquisition: An IPD Meta-analysisCharles Morrison; Fiscal Year: 2012....
- Prevention of HIV transmission/acquisition through informed contraceptive choiceDanny J Schust; Fiscal Year: 2013....
- ENDOMETRIAL VEGF: ENDOCRINE REGULATION OF ANGIOGENESISRobert Taylor; Fiscal Year: 1999..An understanding of the cellular expression of VEGF and the endocrine regulation of endometrial angiogenesis should provide new targets to improve the acceptability of these effective contraceptive devices. ..
- CONFIRMATION STUDIES OF BLOOD BASED BIOMARKERS OF RISK FOR BREAST CANCERSamir M Hanash; Fiscal Year: 2012..The proposed project has the potential to contribute clinically relevant breast cancer biomarkers to identify women at increased risk and to clarify breast cancer risk associated with postmenopausal hormone therapy. ..
- Modulation of innate immunity,microbiome and HIV transmission by Depo-ProveraZhiheng Pei; Fiscal Year: 2013..The results of our studies will provide a better understanding of how DMPA modulates immunologic responses and microbiomes, thereby informing the design of effective HIV prevention strategies. ..
- HORMONAL CONTRACEPTON & RISK OF HIV ACQUISITIONMORRISON CHARLES; Fiscal Year: 2010..abstract_text> ..
- CGMP PROTEIN KINASE IN PREGNANT MYOMETRIUMTrudy Cornwell; Fiscal Year: 2000..Clarification of the regulation of cG-kinase by progesterone will provide insight into the design of tocolytic therapies based on nitric oxide and cGMP actions. ..
- OVARIAN STEROIDS AND CALCIUM HOMEOSTASISNEIL BRESLAU; Fiscal Year: 1991..The potential ability of oral contraceptives (as an adjunctive agent in treating hirsutism) and the nonsteroidal estrogen antagonist tamoxifen (as an adjunctive agent in treating breast cancer) to protect bone will be evaluated...
- INITIATING CONTRACEPTION IN AN STD CLINIC SETTINGJudith Shlay; Fiscal Year: 1999..3%. Such a program has the potential of addressing comprehensive reproductive care from the context of the STD clinic and, if successful, may offer a useful model for other STD programs to consider. ..
- HORMONAL CONTRACEPTON &RISK OF HIV ACQUISITIONElaine D Eaker; Fiscal Year: 2009....
- FEMORAL OSTEOPOROSIS IN ELDERLY WOMENSusan Greenspan; Fiscal Year: 1999..Data derived from this study should provide the basic for an effective intervention to stabilize or increase femoral bone mass and reserve architectural integrity in elderly women. ..
- ER beta selective agonist coronary protection-menopauseR Hermsmeyer; Fiscal Year: 2005..The new ERbetaA is to be contrasted with PremPro(r) (oral conjugated equine estrogens plus medroxyprogesterone acetate) which failed to provide cardiovascular protection in the Women's Health Initiative. ..
- Progestin Actions in the Primate Breast and UterusCharles Wood; Fiscal Year: 2009..This work will have immediate public health relevance to postmenopausal women seeking the safest form of hormone therapy. ..
- DIHYDRODIOL DEHYDROGENASE & PAH DETOXIFICATIONTREVOR PENNING; Fiscal Year: 1992....
- Hormone Replacement and Cerebral Glucose MetabolismJohn Woodard; Fiscal Year: 2000....
- Progestin Levels and Inflammation in PostmenopausePeifeng Hu; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- ADOLESCENT MISCONCEPTIONS ABOUT HORMONAL CONTRACEPTIONLIANA CLARK; Fiscal Year: 2003..Increased usage and improved compliance with Depo-Provera, Norplant and the oral contraceptive pill will result in an overall decrease in the rate of unintended adolescent pregnancy. ..
- HORMONE REPLACEMENT AND METABOLIC CARDIOVASCULAR RISKCynthia Sites; Fiscal Year: 2003..In addition, our study may allow physicians to target hormone replacement to women with specific body compositions. ..
- EXERCISE, ESTROGEN AND AGING--CARDIAC FUNCTION IN WOMENROBERT SPINA; Fiscal Year: 1999..Blood volume will be measured by determining red cell and plasma volumes by standard radionuclide techniques. Arterial stiffness will be evaluated by measurement of pulse wave velocity. ..
- INJECTABLE CONTRACEPTIVES AND BONE ULTRASOUND MEASURESLynn Rosenberg; Fiscal Year: 2005..Millions of women worldwide have used IPCs. Given the heavy burden of osteoporotic fractures in elderly women, it is of public health importance to determine whether IPCs have an adverse effect on bone. ..
- Modulation of Estrogen-regulated Genes by PR IsoformsDJUANA HARVELL; Fiscal Year: 2006..Together, these experiments will define how PRs influence +E signaling in breast cancers. ..
- Progestogen Inhibition of Ovarian Cancer Cell MetastasisWilliam Murdoch; Fiscal Year: 2003....
- HORMONES, THE BRAIN AND BEHAVIORDoris Zumpe; Fiscal Year: 1999..Comparisons between monkeys and rats will help elucidate a previously identified species difference in mating-induced c-fos expression. ..
- CORONARY ANGIOGRAPHIC TRIAL OF ESTROGEN THERAPYHOWARD HODIS; Fiscal Year: 2001..Hard data on this critical issue is needed for physicians to weigh the risk/benefit concerning HRT in postmenopausal women in order to set practice patterns. ..
- Estrogen Modulates Injury-Induced InflammationSuzanne Oparil; Fiscal Year: 2007..These fundamental mechanistic studies will enhance our understanding of the pathobiology of vascular disease, particularly as it occurs in aging women, and will provide the basis for development of novel therapeutic strategies. ..
- RANDOMIZED TRIAL OF ESTROGEN-ATHEROSCLEROSIS REGRESSIONThomas Clarkson; Fiscal Year: 1992....
- Effect of hormonal contraception on bone mineral densityAbbey Berenson; Fiscal Year: 2005..Ultimately, this study will determine which women, if any, are placed at increased risk of osteopenia or osteoporosis as a result of using these hormonal contraceptives during their reproductive years. ..
- DEPO PROVERA AND BONE MINERAL DENSITY IN ADOLESCENTSBarbara Cromer; Fiscal Year: 2003..The statistical analysis will estimate the effect of DMPA on bone density while taking account of constant treatment discontinuation throughout the study period. ..
- Depo-provera & BMD: Continuing ObservationsM Clark; Fiscal Year: 2005..The longitudinal design will be continued, maintaining all methods and protocols employed in the parent study. ..
- The effect of nonoxynol-9 on human endometriumJohn Jain; Fiscal Year: 2005..The results of this study will provide important preliminary information on the role of microbicides on endometrial toxicity and may help guide future research priorities. ..
- Ectopic Pregnancy: Assessing Long-Term Trends in Rates and Risk FactorsDelia Scholes; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- DOXYCYCLINE FOR BLEEDING IN PROGESTIN ONLY CONTRACEPTORSDavid Archer; Fiscal Year: 2006..If successful, DOX treatment could become an important adjuvant for treatment of this and possibly other inflammatory disorders effecting reproductive tract tissues. ..
- Oral Contraceptive Use and Bone Density in Young WomenDelia Scholes; Fiscal Year: 2008..abstract_text> ..
- Prevention of Weight Gain in Young AdultsMark Espeland; Fiscal Year: 2009..This approach shows promise for reducing weight gain and thereby improving long-term cardiovascular health. (End of Abstract) ..
- Seniors Health and Activity Research Program Pilot (SHARP-P)Mark Espeland; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORKBruce Carr; Fiscal Year: 2004..In summary, the reproductive endocrinology research team is experienced in multi- center clinical trials and is committed to collaborative participation consistent with the goals of the RMU network. ..
- Thrombosis Gene Polymorphisms and Early CHD Risk in HERSDavid Herrington; Fiscal Year: 2004....
- Soy and Estrogen Interactions in the BreastJ Cline; Fiscal Year: 2009..The proposed work will provide a unique view of an otherwise inaccessible period of breast development in a primate model with high genetic and physiologic similarity to human beings. ..
- PHYSIOLOGY OF REPRODUCTIONBruce Carr; Fiscal Year: 2003..D. and 5 M.D. trainees, on average) and 2 predoctoral students matriculating for the Ph.D. degree. During the past 10 years, 45 postdoctoral and predoctoral trainees have been supported by this grant. ..
- A MECHANISTIC STUDY OF SKELETAL ACTIONS OF 1-34hPTHRobert Lindsay; Fiscal Year: 2009..abstract_text> ..
- Estrogen Receptor Variance and CHD Risk in HERSDavid Herrington; Fiscal Year: 2004..In addition, this information could lead to fundamentally important new knowledge about mechanisms of estrogen action, regulation of HDL cholesterol, and pathogenesis of CHD. ..
- Effects of Dietary Soy on Biomarkers in Prostate CancerJ Cline; Fiscal Year: 2004..abstract_text> ..
- UCSF-KAISER WOMEN'S HEALTH INTERDISCIPLINARY SCHOLARSHIPDeborah Grady; Fiscal Year: 2004..Our goal is to create a model national resource for training successful investigators in women's health. ..
- Progesterone, GABA Receptors and Cell SurvivalMeharvan Singh; Fiscal Year: 2005..abstract_text> ..
- Estrogen Receptor Variants,HDL, and AtherosclerosisDavid Herrington; Fiscal Year: 2005....
- Machine Learning to Identify Complex Interactions in Genome-Wide Association DataDavid Herrington; Fiscal Year: 2009..Determining specific genetic and/or environmental factors that influence a person's risk of disease may help doctors reduce risk for disease and reveal new treatments for disease. (End of Abstract) ..
- A DIAGNOSTIC TEST TO ASSESS RISK ASSOCIATED WITH ANDROGEN THERAPYMeharvan Singh; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Intrauterine Inflammation & Adverse Neurological OutcomeMichal A Elovitz; Fiscal Year: 2010..abstract_text> ..
- Membrane Androgen Receptors in NeuroprotectionMeharvan Singh; Fiscal Year: 2007..unreadable] [unreadable]..