progesterone

Summary

Summary: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.

Top Publications

  1. pmc Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
    J Julie Kim
    Division of Reproductive Biology Research, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Endocr Rev 34:130-62. 2013
  2. pmc WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse
    Heather L Franco
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 25:1176-87. 2011
  3. ncbi Progesterone activates the principal Ca2+ channel of human sperm
    Polina V Lishko
    Department of Physiology, University of California San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F, 600 16th Street, San Francisco, California 94158, USA
    Nature 471:387-91. 2011
  4. ncbi Progesterone induces adult mammary stem cell expansion
    Purna A Joshi
    Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada
    Nature 465:803-7. 2010
  5. ncbi The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
    Timo Strünker
    Center of Advanced European Studies and Research, Abteilung Molekulare Neurosensorik, Ludwig Erhard Allee 2, 53175 Bonn, Germany
    Nature 471:382-6. 2011
  6. ncbi Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
    J P Lydon
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 9:2266-78. 1995
  7. ncbi Expression of mRNAs for interleukin-4, interleukin-6 and their receptors in porcine corpus luteum during the estrous cycle
    Ryosuke Sakumoto
    Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305 8602, Japan
    Domest Anim Endocrinol 31:246-57. 2006
  8. ncbi Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles
    E Bosch
    Department of Reproduction, Instituto Valenciano de Infertilidad, University of Valencia, Plaza de la Policia Local, 3, 46015 Valencia, Spain
    Hum Reprod 25:2092-100. 2010
  9. ncbi The hormonal control of uterine luminal fluid secretion and absorption
    N Salleh
    Division of Reproductive Health, Endocrinology and Development, Guy s Campus, King s College, London, SE1 1UL, UK
    J Membr Biol 206:17-28. 2005
  10. ncbi Multiple sclerosis: neuroprotective alliance of estrogen-progesterone and gender
    Markus Kipp
    Institute of Neuroanatomy, RWTH Aachen University, 52074 Aachen, Germany
    Front Neuroendocrinol 33:1-16. 2012

Detail Information

Publications360 found, 100 shown here

  1. pmc Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
    J Julie Kim
    Division of Reproductive Biology Research, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Endocr Rev 34:130-62. 2013
    b>Progesterone receptor (PR) mediates the actions of the ovarian steroid progesterone, which together with estradiol regulates gonadotropin secretion, prepares the endometrium for implantation, maintains pregnancy, and differentiates breast ..
  2. pmc WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse
    Heather L Franco
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 25:1176-87. 2011
    ..and subsequent defects in endometrial stromal cell survival, differentiation, and responsiveness to progesterone signaling...
  3. ncbi Progesterone activates the principal Ca2+ channel of human sperm
    Polina V Lishko
    Department of Physiology, University of California San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F, 600 16th Street, San Francisco, California 94158, USA
    Nature 471:387-91. 2011
    Steroid hormone progesterone released by cumulus cells surrounding the egg is a potent stimulator of human spermatozoa. It attracts spermatozoa towards the egg and helps them penetrate the egg's protective vestments...
  4. ncbi Progesterone induces adult mammary stem cell expansion
    Purna A Joshi
    Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada
    Nature 465:803-7. 2010
    ..Here we show that the MaSC pool increases 14-fold during maximal progesterone levels at the luteal dioestrus phase of the mouse...
  5. ncbi The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
    Timo Strünker
    Center of Advanced European Studies and Research, Abteilung Molekulare Neurosensorik, Ludwig Erhard Allee 2, 53175 Bonn, Germany
    Nature 471:382-6. 2011
    In the oviduct, cumulus cells that surround the oocyte release progesterone. In human sperm, progesterone stimulates a Ca(2+) increase by a non-genomic mechanism...
  6. ncbi Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
    J P Lydon
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 9:2266-78. 1995
    Although progesterone has been recognized as essential for the establishment and maintenance of pregnancy, this steroid hormone has been recently implicated to have a functional role in a number of other reproductive events...
  7. ncbi Expression of mRNAs for interleukin-4, interleukin-6 and their receptors in porcine corpus luteum during the estrous cycle
    Ryosuke Sakumoto
    Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305 8602, Japan
    Domest Anim Endocrinol 31:246-57. 2006
    ..Moreover, the effects of these cytokines on progesterone (P(4)), estradiol-17beta (E(2)) and prostaglandin (PG) F2alpha secretion by cultured luteal cells were ..
  8. ncbi Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles
    E Bosch
    Department of Reproduction, Instituto Valenciano de Infertilidad, University of Valencia, Plaza de la Policia Local, 3, 46015 Valencia, Spain
    Hum Reprod 25:2092-100. 2010
    The influence of elevated serum progesterone levels during in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles on pregnancy rates is a matter of continued debate among fertility clinicians...
  9. ncbi The hormonal control of uterine luminal fluid secretion and absorption
    N Salleh
    Division of Reproductive Health, Endocrinology and Development, Guy s Campus, King s College, London, SE1 1UL, UK
    J Membr Biol 206:17-28. 2005
    ..of steroid treatment of ovariectomized rats mimicking early pregnancy, oestradiol caused fluid secretion, while progesterone resulted in an amiloride-sensitive fluid absorption...
  10. ncbi Multiple sclerosis: neuroprotective alliance of estrogen-progesterone and gender
    Markus Kipp
    Institute of Neuroanatomy, RWTH Aachen University, 52074 Aachen, Germany
    Front Neuroendocrinol 33:1-16. 2012
    The potential of 17β-estradiol and progesterone as neuroprotective factors is well-recognized. Persuasive data comes from in vitro and animal models reflecting a wide range of CNS disorders...
  11. ncbi Follicle-stimulating hormone regulation of microRNA expression on progesterone production in cultured rat granulosa cells
    Nan Yao
    Graduate School of Peking Union Medical College, Beijing, China
    Endocrine 38:158-66. 2010
    ..Here we show that expression of 31 miRNAs is altered during FSH-mediated progesterone secretion of cultured granulosa cells...
  12. pmc Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient
    James F Smith
    Department of Urology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 110:6823-8. 2013
    The female steroid hormone progesterone regulates ovulation and supports pregnancy, but also controls human sperm function within the female reproductive tract...
  13. ncbi Regulation of vascular smooth muscle cell expression and function of matrix metalloproteinases is mediated by estrogen and progesterone exposure
    Oscar H Grandas
    Department of Surgery, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee, USA
    J Vasc Surg 49:185-91. 2009
    ..We hypothesize that estrogen (Est) and progesterone (Prog) upregulate the MMP pathway in vascular smooth muscle cells (VSMCs) thereby increasing MMP activity and ..
  14. ncbi Progesterone and interferon-tau regulate cystatin C in the endometrium
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A and M University, College Station, 77843 2471, USA
    Endocrinology 147:3478-83. 2006
    ..This study determined effects of the estrous cycle, pregnancy, progesterone (P4), and interferon-tau (IFNT) on CST3 in the ovine uterus...
  15. ncbi Progesterone and the risk of preterm birth among women with a short cervix
    Eduardo B Fonseca
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    N Engl J Med 357:462-9. 2007
    Previous randomized trials have shown that progesterone administration in women who previously delivered prematurely reduces the risk of recurrent premature delivery...
  16. ncbi Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives
    Birgit Gellersen
    Endokrinologikum Hamburg, Hamburg, Germany
    Semin Reprod Med 25:445-53. 2007
    ..This differentiation process is dependent entirely on the convergence of the cyclic adenosine monophosphate and progesterone signaling pathways that drives integrated changes at both the transcriptome and the proteome level...
  17. pmc Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
    Manfred Beleut
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research ISREC, NCCR Molecular Oncology, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 107:2989-94. 2010
    The mouse mammary gland develops postnatally under the control of female reproductive hormones. Estrogens and progesterone trigger morphogenesis by poorly understood mechanisms acting on a subset of mammary epithelial cells (MECs) that ..
  18. pmc Progesterone increases susceptibility and decreases immune responses to genital herpes infection
    Charu Kaushic
    Department of Pathology and Molecular Medicine, Center of Gene Therapeutics, McMaster University Health Sciences Center, Hamilton, Ontario, Canada
    J Virol 77:4558-65. 2003
    ..of mice to genital herpes simplex virus type 2 (HSV-2) after Depo-provera or a saline suspension of progesterone (P-sal)...
  19. ncbi Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Immunol 181:1470-9. 2008
    ..by mechanical stretch of the uterus imposed by the growing fetus and negatively by physiological withdrawal of progesterone (P4)...
  20. ncbi Steroid fluctuations modify functional cerebral asymmetries: the hypothesis of progesterone-mediated interhemispheric decoupling
    M Hausmann
    AE Biopsychologie, Fakultat fur Psychologie, Ruhr Universitat Bochum, D 44780, Bochum, Germany
    Neuropsychologia 38:1362-74. 2000
    ..Saliva progesterone levels were measured with radioimmunoassay (RIA)...
  21. ncbi Hormonal induction of endometrial receptivity
    Richard J Paulson
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Fertil Steril 96:530-5. 2011
    ..To review and synthesize information from the scientific literature pertaining to the hormonal induction of endometrial receptivity before ET...
  22. ncbi Copper/zinc superoxide dismutase insufficiency impairs progesterone secretion and fertility in female mice
    Yoshihiro Noda
    Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biol Reprod 86:1-8. 2012
    ..hormone, and estradiol were not altered in the mutant compared to the wild-type females, while the plasma progesterone level was significantly reduced in the mutant females...
  23. ncbi Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases
    V Boonyaratanakornkit
    University of Colorado School of Medicine, Pathology Department and Molecular Biology Program, Denver, CO 80262, USA
    Mol Cell 8:269-80. 2001
    ..We have identified a specific polyproline motif in the amino-terminal domain of conventional progesterone receptor (PR) that mediates direct progestin-dependent interaction of PR with SH3 domains of various ..
  24. ncbi Altered gene expression profiling in endometrium: evidence for progesterone resistance
    Lusine Aghajanova
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143 0132, USA
    Semin Reprod Med 28:51-8. 2010
    b>Progesterone plays an important role in regulating multiple events in the uterus. It controls endometrial proliferation and differentiation, which are important for uterine function...
  25. ncbi Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation
    N Forde
    School of Agriculture, Food Science, and Veterinary Medicine, and Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Biol Reprod 84:266-78. 2011
    In cattle, elevated concentrations of circulating progesterone (P4) in the immediate postconception period are associated with advanced conceptus development, while low P4 is implicated as a causative factor in low pregnancy rates ..
  26. ncbi Intrahepatic cholestasis of pregnancy: Amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine
    Anna Glantz
    Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital East, Gothenburg, Sweden
    Hepatology 47:544-51. 2008
    ..of pregnancy (ICP) is characterized by pruritus, elevated bile acids, and, specifically, elevated disulphated progesterone metabolites...
  27. ncbi Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis
    E Labarta
    Department of Human Reproduction, University of Valencia, Valencia, Spain
    Hum Reprod 26:1813-25. 2011
    Elevated serum progesterone levels at the end of the follicular phase in controlled ovarian stimulation (COS) leads to a poorer ongoing pregnancy rate in IVF cycles due to reduced endometrial receptivity...
  28. pmc The biology of progesterone receptor in the normal mammary gland and in breast cancer
    Alison E Obr
    Departments of Molecular and Cellular Biology and Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Endocrinol 357:4-17. 2012
    This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse mammary gland that has been used extensively as an experimental model...
  29. pmc Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial
    Guomin Xiao
    Department of Neurosurgery and Neurotrauma Center, Affiliated Hospital, College of Medicine, Hangzhou Normal University, Hangzhou 310015, China
    Crit Care 12:R61. 2008
    ..Although there are a number of animal models of TBI using progesterone for head injury, the effects of progesterone on neurologic outcome of acute TBI patients remain unclear...
  30. ncbi High feed intake increases liver blood flow and metabolism of progesterone and estradiol-17beta in dairy cattle
    S Sangsritavong
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Dairy Sci 85:2831-42. 2002
    ..Similarly, progesterone (P4) and estradiol-17beta (E2) were administered by continuous infusion...
  31. ncbi Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis
    Yan Wu
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    Epigenetics 1:106-11. 2006
    The physiological effects of progesterone (P) are mediated by two isoforms of progesterone receptors (PRs): PR-A and PR-B...
  32. pmc Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 t
    Luigi Cicatiello
    Dipartimento di Patologia Generale, Seconda Universita degli Studi di Napoli, 80138 Naples, Italy
    Mol Cell Biol 24:7260-74. 2004
    ..Interestingly, progesterone triggers similar regulatory events through its own NRs, suggesting that the gene regulation cascade described ..
  33. ncbi ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury
    David W Wright
    Department of Emergency Medicine, School of Medicine of Emory University, Atlanta, GA, USA
    Ann Emerg Med 49:391-402, 402.e1-2. 2007
    Laboratory evidence indicates that progesterone has potent neuroprotective effects. We conducted a pilot clinical trial to assess the safety and potential benefit of administering progesterone to patients with acute traumatic brain injury.
  34. ncbi Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone
    Kenneth W Beagley
    School of Biomedical Sciences, The University of Newcastle, Royal Newcastle Hospital, Newcastle, NSW 2300, Australia
    FEMS Immunol Med Microbiol 38:13-22. 2003
    ..This review describes what is currently known about the effects of the female sex hormones oestradiol and progesterone on innate and adaptive immune responses in order to provide a framework for understanding these sex differences...
  35. ncbi Progesterone attenuates neurological behavioral deficits of experimental autoimmune encephalomyelitis through remyelination with nucleus-sublocalized Olig1 protein
    Hong jun Yu
    Department of Rehabilitation, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Neurosci Lett 476:42-5. 2010
    ..The deterioration of the disease is characterized by the axonal loss with defective remyelination. Progesterone can promote the remyelination, but whether it exerts beneficial effect on treatment of MS still remains unclear...
  36. pmc A computer simulation of progesterone and Cox2 inhibitor treatment for preterm labor
    Ozlem Equils
    Department of Pediatrics, Burns and Allen Research Institute, Cedars Sinai Medical Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e8502. 2010
    ..This development allows the in silico investigation of pathological mechanisms and the trialing of potential treatments...
  37. pmc Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer
    Kuang Tzu Huang
    Department of Medicine, New York University School of Medicine, New York, United States of America
    PLoS ONE 7:e46072. 2012
    ..Conversely, progesterone (Pg) as an inhibitor of endometrial proliferation increases nuclear p27 and Cdh1 in primary EECs and ECA cells...
  38. ncbi Progesterone stimulation of fluid absorption by the rat uterine gland
    R J Naftalin
    Division of Physiology, King s College London, New Hunt s House, Guys Campus, SE1 1UL, UK
    Reproduction 123:633-8. 2002
    ..Under progesterone dominance, the glands showed an amiloride-sensitive dextran accumulation indicating sodium-dependent fluid ..
  39. pmc Progesterone is essential for maintenance and growth of uterine leiomyoma
    Hiroshi Ishikawa
    Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, Department of Obstetrics and Gynecology, 4th Floor, Suite 4 127, 303 East Superior Street, Chicago, Illinois 60611, USA
    Endocrinology 151:2433-42. 2010
    ..of UL growth on ovarian steroids is well established, the relative contributions of 17beta-estradiol and progesterone are yet to be clarified...
  40. ncbi Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells
    Jennifer K Richer
    Department of Medicine Endocrinology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Biol Chem 277:5209-18. 2002
    The PR-A and PR-B isoforms of progesterone receptors (PR) have different physiological functions, and their ratio varies widely in breast cancers...
  41. ncbi Women's attractiveness changes with estradiol and progesterone across the ovulatory cycle
    David A Puts
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Horm Behav 63:13-9. 2013
    ..changed over the cycle as a function of two likely candidates for mediating these changes: estradiol and progesterone. We scheduled women to attend one session during the late follicular phase and another during the mid-luteal ..
  42. pmc Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype
    Shadi Abu-Hayyeh
    Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
    Hepatology 57:716-26. 2013
    ..The endocrine signals that cause cholestasis are not known but 3α-sulfated progesterone metabolites have been shown to be elevated in ICP, leading us to study the impact of sulfated progesterone ..
  43. ncbi Transcriptomic analysis of the bovine endometrium: What is required to establish uterine receptivity to implantation in cattle?
    Niamh Forde
    School of Agriculture and Food Science, University College Dublin, Dublin 4, Ireland
    J Reprod Dev 58:189-95. 2012
    ..The two main modulators of these processed are progesterone (P4) and the pregnancy recognition signal interferon tau (IFNT)...
  44. pmc Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes
    Christine L Clarke
    Westmead Institute for Cancer Research, Sydney Medical School Westmead, University of Sydney at the Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia
    PLoS ONE 7:e35859. 2012
    The transcriptional effects of the ovarian hormone progesterone are pleiotropic, and binding to DNA of the nuclear progesterone receptor (PR), a ligand-activated transcription factor, results in diverse outcomes in a range of target ..
  45. ncbi Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles
    Bei Xu
    Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Fertil Steril 97:1321-7.e1-4. 2012
    ..To investigate the relationship between serum P levels on the day of hCG administration and pregnancy outcomes in different responders undergoing IVF...
  46. ncbi Estrogen and progesterone control of gene expression in the mouse meibomian gland
    Tomo Suzuki
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 49:1797-808. 2008
    The purpose of the study was to test the hypothesis that estrogen and progesterone regulate gene expression in the meibomian gland.
  47. pmc Progesterone analogs influence germination of Clostridium sordellii and Clostridium difficile spores in vitro
    Marc Liggins
    Department of Chemistry, University of Nevada, Las Vegas, Las Vegas, Nevada 89154, USA
    J Bacteriol 193:2776-83. 2011
    ..difficile spore germination. Thus, even though C. sordellii and C. difficile are phylogenetically related, the two species' spores respond differently to steroidal compounds...
  48. ncbi Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
    Pamela A Williams
    Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, UK
    Science 305:683-6. 2004
    ..three crystal structures of CYP3A4: unliganded, bound to the inhibitor metyrapone, and bound to the substrate progesterone. The structures revealed a surprisingly small active site, with little conformational change associated with ..
  49. ncbi Progesterone signalling in breast cancer: a neglected hormone coming into the limelight
    Cathrin Brisken
    ISREC Swiss Institute for Experimental Cancer Research, National Center of Competence for Molecular Oncology, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, SV2 832 Station 19, CH 1015 Lausanne, Switzerland
    Nat Rev Cancer 13:385-96. 2013
    ..Early progesterone receptor (PR) antagonists, however, were dismissed because of severe side effects, but awareness is now ..
  50. ncbi Progesterone-regulated changes in endometrial gene expression contribute to advanced conceptus development in cattle
    N Forde
    School of Agriculture, Food Science and Veterinary Medicine, Conway Institute, College of Life Sciences, University College Dublin, Belfield, Dublin, Ireland
    Biol Reprod 81:784-94. 2009
    The postovulatory rise in circulating progesterone (P4) concentrations is associated with increased pregnancy success in beef and dairy cattle...
  51. ncbi Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression
    I Van Vaerenbergh
    Vrije Universiteit Brussel and UZ Brussel, Department of Pathology, Jette, Belgium
    Reprod Biomed Online 22:263-71. 2011
    Premature progesterone rise during gonadotrophin-releasing hormone (GnRH) antagonist cycles for IVF is a frequent phenomenon and has been associated with lower pregnancy and implantation rates...
  52. ncbi Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A
    Amy A Merlino
    Department of Reproductive Biology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 5034, USA
    J Clin Endocrinol Metab 92:1927-33. 2007
    We examined whether human parturition involves functional progesterone withdrawal mediated by changes in myometrial expression of progesterone receptors (PRs)-A and -B.
  53. pmc Research resource: Genome-wide profiling of progesterone receptor binding in the mouse uterus
    Cory A Rubel
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030
    Mol Endocrinol 26:1428-42. 2012
    b>Progesterone (P4) signaling through its nuclear transcription factor, the progesterone receptor (PR), is essential for normal uterine function...
  54. ncbi Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 79:1226-36. 2008
    b>Progesterone (P4) is unequivocally required to maintain a uterine environment conducive to pregnancy...
  55. ncbi Effect of increasing progesterone concentration from Day 3 of pregnancy on subsequent embryo survival and development in beef heifers
    F Carter
    School of Agriculture, Food Science and Veterinary Medicine, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
    Reprod Fertil Dev 20:368-75. 2008
    Higher systemic progesterone in the immediate post-conception period is associated with an increase in embryonic growth rate, interferon-tau production and pregnancy rate in cattle...
  56. ncbi Ca2+ signaling tools acquired from prostasomes are required for progesterone-induced sperm motility
    Kwang Hyun Park
    Department of Biochemistry, Chonbuk National University Medical School, JeonJu 561 180, Korea
    Sci Signal 4:ra31. 2011
    b>Progesterone-induced calcium ion (Ca2+) signals in the neck region of sperm play a pivotal role in promoting sperm motility...
  57. ncbi Select nutrients and their associated transporters are increased in the ovine uterus following early progesterone administration
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 82:224-31. 2010
    ..The present study identified alterations in glucose and amino acids in response to an early rise in progesterone (P4), which accelerates blastocyst growth and development...
  58. ncbi Behavioral response of human spermatozoa to a concentration jump of chemoattractants or intracellular cyclic nucleotides
    Anna Gakamsky
    Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Hum Reprod 24:1152-63. 2009
    ..A major question in mammalian sperm chemotaxis is whether the cells sense a chemoattractant gradient by comparing the chemoattractant concentration between time points or between spatial points...
  59. pmc Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data
    Roberto Romero
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, and Detroit, MI, USA
    Am J Obstet Gynecol 206:124.e1-19. 2012
    To determine whether the use of vaginal progesterone in asymptomatic women with a sonographic short cervix (≤ 25 mm) in the midtrimester reduces the risk of preterm birth and improves neonatal morbidity and mortality.
  60. pmc Gastrin-releasing peptide (GRP) in the ovine uterus: regulation by interferon tau and progesterone
    Gwonhwa Song
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 79:376-86. 2008
    ..These studies determined the effects of pregnancy, progesterone (P4), interferon tau (IFNT), placental lactogen (CSH1), and growth hormone (GH) on expression of GRP in the ..
  61. pmc The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2
    Quanxi Li
    Department of Comparative Biosciences, University of Illinois Urbana Champaign, Urbana, IL 61820, USA
    Science 331:912-6. 2011
    During pregnancy, progesterone inhibits the growth-promoting actions of estrogen in the uterus. However, the mechanism for this is not clear...
  62. pmc miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor
    Nora E Renthal
    Department of Biochemistry, North Texas March of Dimes Birth Defects Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:20828-33. 2010
    Throughout most of pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is initiated/facilitated by a concerted series of biochemical events that activate ..
  63. ncbi Progesterone: therapeutic opportunities for neuroprotection and myelin repair
    Michael Schumacher
    UMR 788 Inserm and University Paris Sud 11, Kremlin Bicetre, France
    Pharmacol Ther 116:77-106. 2007
    b>Progesterone and its metabolites promote the viability of neurons in the brain and spinal cord...
  64. ncbi Progesterone receptors in the human pregnancy uterus: do they hold the key to birth timing?
    Sam Mesiano
    Department of Reproductive Biology and Obstetrics and Gynecology, University Hospitals Case Medical Center, Cleveland, OH 44106 5034, USA
    Reprod Sci 18:6-19. 2011
    ..b>Progesterone, through specific progesterone receptors (PRs) in uterine tissues, is key player in this process...
  65. pmc Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice
    W Tong
    Departments of Developmental and Molecular Biology and Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 19:2251-64. 1999
    ..a synchronized wave of DNA synthesis and cell division in the epithelial cells, while pretreatment with progesterone (P4) completely inhibits this E2-induced cell proliferation...
  66. ncbi Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats
    Courtney L Robertson
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Exp Neurol 197:235-43. 2006
    ..b>Progesterone has emerged as a key hormone involved in many potential neuroprotective pathways after acute brain injury and ..
  67. ncbi Progesterone enhances HLA-G gene expression in JEG-3 choriocarcinoma cells and human cytotrophoblasts in vitro
    Shang mian Yie
    Department of Gynecology and Obstetrics, Sunnybrook and Women s College Health Science Center, Toronto, Ontario, Canada
    Hum Reprod 21:46-51. 2006
    ..However, regulation of HLA-G gene expression is not well understood. Many studies have suggested that progesterone may also be important in suppressing maternal immune response to the fetus...
  68. pmc Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial
    S S Hassan
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Ultrasound Obstet Gynecol 38:18-31. 2011
    ..This study was undertaken to determine the efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short ..
  69. ncbi Are animal models relevant to key aspects of human parturition?
    Bryan F Mitchell
    Department of Obstetrics and Gynecology, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R525-45. 2009
    ..suggests two major mechanisms regulating the timing of parturition: the withdrawal of the steroid hormone progesterone and a proinflammatory response by the immune system...
  70. pmc Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2
    Amy E Gillgrass
    Center of Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Center 4H30F, 1200 Main Street West, Hamilton, Ontario, Canada L8P 3Z5
    J Virol 77:9845-51. 2003
    ..These results indicate that longer exposure to Depo leads to poor innate and adaptive immune responses to HSV-2 that fail to protect mice from subsequent genital challenges...
  71. ncbi Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses
    Thomas E Spencer
    Center for Animal Biotechnology andGenomics, Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Reprod Fertil Dev 19:65-78. 2007
    ..on pregnancy recognition and conceptus development and implantation in sheep with respect to regulation by progesterone, interferons and endogenous retroviruses...
  72. ncbi Fetal programming: prenatal testosterone treatment leads to follicular persistence/luteal defects; partial restoration of ovarian function by cyclic progesterone treatment
    Mohan Manikkam
    Department of Pediatrics, University of Michigan, Ann Arbor, 48109 0404, USA
    Endocrinology 147:1997-2007. 2006
    ..We hypothesized that follicular persistence causes polycystic ovaries and that cyclic progesterone (P) treatment would overcome follicular persistence and restore cyclicity...
  73. ncbi Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle
    J E Fata
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Biol Reprod 65:680-8. 2001
    ..Epithelial proliferation and apoptosis exhibited a positive relationship with serum levels of progesterone, but not with 17beta-estradiol...
  74. ncbi Effects of time of progesterone supplementation on embryo development and interferon-tau production in the cow
    G E Mann
    Division of Animal Physiology, School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK
    Vet J 171:500-3. 2006
    We have investigated the effects of the timing of progesterone supplementation on early embryo development in mature, non-lactating Holstein-Friesian cows...
  75. ncbi Control of mammary stem cell function by steroid hormone signalling
    Marie Liesse Asselin-Labat
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Nature 465:798-802. 2010
    The ovarian hormones oestrogen and progesterone profoundly influence breast cancer risk, underpinning the benefit of endocrine therapies in the treatment of breast cancer...
  76. ncbi Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study
    Eduardo B da Fonseca
    Obstetrics Clinic, University of Sao Paulo Medical School, Brazil
    Am J Obstet Gynecol 188:419-24. 2003
    The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population.
  77. ncbi Functional changes of mouse placental multidrug resistance phosphoglycoprotein (ABCB1) with advancing gestation and regulation by progesterone
    Sophie Petropoulos
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Reprod Sci 14:321-8. 2007
    ..will result in increased transplacental transfer of ABCB1 substrates over the second half of gestation and that progesterone exhibits a regulatory role on placental ABCB1 expression and function...
  78. ncbi DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen
    Yoshiaki Yamagata
    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Minamikogushi 1 1 1, Ube 755 8505, Japan
    Hum Reprod 24:1126-32. 2009
    ..We investigated expression of DNA methyltransferases (DNMTs) in endometrium during the menstrual cycle and the influence of sex steroid hormones on DNMT in endometrial stromal cells (ESC) in culture...
  79. ncbi Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients
    J Smitz
    Follicle Biology Laboratory and Center for Reproductive Medicine, Academisch Ziekenhuis Vrije Universiteit Brussel, Belgium
    Hum Reprod 22:676-87. 2007
    ..Highly purified menotrophin (HP-hMG) has been associated with fewer oocytes retrieved and a higher proportion of top-quality embryos compared with recombinant FSH (rFSH)...
  80. pmc Progesterone receptors, their isoforms and progesterone regulated transcription
    Britta M Jacobsen
    Department of Medicine Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States
    Mol Cell Endocrinol 357:18-29. 2012
    This review discusses mechanisms by which progesterone receptors (PR) regulate transcription...
  81. pmc Progesterone: the ultimate endometrial tumor suppressor
    Shujie Yang
    Department of Obstetrics and Gynecology and Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA
    Trends Endocrinol Metab 22:145-52. 2011
    ..Estrogen drives epithelial proliferation, and progesterone inhibits growth and causes cell differentiation...
  82. pmc Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice
    Wei Lei
    Department of Biology, Shantou University, Shantou 515063, China
    J Biol Chem 287:15174-92. 2012
    ..are markedly induced in mouse uterine stromal cells undergoing decidualization, only RRM2 is regulated by progesterone, a key regulator of decidualization...
  83. ncbi Candidates for membrane progestin receptors--past approaches and future challenges
    Yong Zhu
    Department of Biology, East Carolina University, 1000 E 5th Street, Greenville, NC 27858, USA
    Comp Biochem Physiol C Toxicol Pharmacol 148:381-9. 2008
    ..Clarification of the controversies surrounding the identities and localization of membrane progestin receptors may help direct future research that could advance our understanding of rapid actions of steroids...
  84. pmc Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus
    Jae Hee Lee
    Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University College of Human Medicine, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA
    FASEB J 27:2553-63. 2013
    ..signal transducer and activator of transcription-3 (Stat3) is required for decidualization, interacting with progesterone receptor (PR) in uterus...
  85. pmc Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 m
    John J Peluso
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Endocrinology 149:534-43. 2008
    b>Progesterone (P4) receptor membrane component-1 (PGRMC1) and its binding partner, plasminogen activator inhibitor 1 RNA binding protein (PAIRBP1) are thought to form a complex that functions as membrane receptor for P4...
  86. pmc Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis
    Serdar E Bulun
    Division of Reproductive Biology Research, Department Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Reprod Med 28:36-43. 2010
    Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease...
  87. ncbi The effect of elevated progesterone and pregnancy status on mRNA expression and localisation of progesterone and oestrogen receptors in the bovine uterus
    L A Okumu
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Reproduction 140:143-53. 2010
    To investigate the effects of pregnancy or post-ovulatory progesterone (P(4)) supplementation on the expression of oestrogen and P(4) receptors (ESRs and PGRs) in the bovine uterus, heifers (n=263) were randomly assigned to the following ..
  88. ncbi Select nutrients in the ovine uterine lumen. III. Cationic amino acid transporters in the ovine uterus and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:602-9. 2009
    ..acid transporters in uteri of cyclic and pregnant ewes and conceptuses was studied, and effects of pregnancy, progesterone (P4), and interferon tau (IFNT) on their expression were investigated...
  89. ncbi Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis
    Richard O Burney
    Department of Obstetrics and Gynecology, Stanford University, Stanford, California 94305, USA
    Endocrinology 148:3814-26. 2007
    ..Comparative gene expression analysis of progesterone-regulated genes in secretory phase endometrium confirmed the observation of attenuated progesterone response...
  90. ncbi Aberrant pre-receptor regulation of estrogen and progesterone action in endometrial cancer
    Tina Smuc
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Mol Cell Endocrinol 301:74-82. 2009
    Endometrial cancer is related to estrogen stimulation not opposed by progesterone. We have examined expression of the pre-receptor regulatory enzymes aromatase, 17beta-hydroxysteroid dehydrogenases (17beta-HSDs), 20alpha-hydroxysteroid ..
  91. pmc Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells
    Ping Yin
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA
    Cancer Res 70:1722-30. 2010
    ..Although progesterone stimulates the proliferation of uterine leiomyoma cells, the mechanism of progesterone action is not well ..
  92. pmc Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids
    Y Majeed
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Pharmacol 162:1509-20. 2011
    ..Steroids are known to modulate fear and anxiety states, and we therefore investigated whether TRPC5 exhibited sensitivity to steroids...
  93. ncbi Estrogen addition to progesterone for luteal phase support in cycles stimulated with GnRH analogues and gonadotrophins for IVF: a systematic review and meta-analysis
    E M Kolibianakis
    Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Nea Efkarpia Peripheral Road, Thessaloniki 54603, Greece
    Hum Reprod 23:1346-54. 2008
    ..The purpose of the present systematic review and meta-analysis was to examine whether the probability of pregnancy is increased by adding estrogen to progesterone for luteal phase support in patients treated by in vitro fertilization (IVF).
  94. ncbi RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis
    Eva Gonzalez-Suarez
    Department of Hematology Oncology Research, Amgen Inc, Seattle, Washington 98119, USA
    Nature 468:103-7. 2010
    ..It has been shown that RANKL is responsible for the major proliferative response of mouse mammary epithelium to progesterone during mammary lactational morphogenesis, and in mouse models, manipulated to induce activation of the RANK/..
  95. ncbi Protective effects of progesterone administration on axonal pathology in mice with experimental autoimmune encephalomyelitis
    Laura Garay
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina
    Brain Res 1283:177-85. 2009
    ..Previous work has shown that progesterone attenuated the clinical severity, demyelination and neuronal dysfunction of EAE mice (Garay et al., J...
  96. ncbi Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex
    M Djebaili
    Brain Research Laboratory, Department of Emergency Medicine, 1648 Pierce Drive, Cell Biology Building, Room 261, Emory University, Atlanta, GA 30322, USA
    Neuroscience 123:349-59. 2004
    We compared the effects of three different doses of allopregnanolone (4, 8 or 16 mg/kg), a metabolite of progesterone, to progesterone (16 mg/kg) in adult rats with controlled cortical impact to the pre-frontal cortex...
  97. ncbi A caged progesterone analog alters intracellular Ca2+ and flagellar bending in human sperm
    M Rocio Servin-Vences
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico UNAM, Apdo Postal 510 3, Cuernavaca, Morelos 62250, Mexico
    Reproduction 144:101-9. 2012
    b>Progesterone is a physiological agonist for mammalian sperm, modulating its flagellar movement and facilitating the acrosome reaction...
  98. pmc Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice
    Jenna C Carroll
    University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191
    Endocrinology 151:2713-22. 2010
    Depletion of estrogens and progesterone at menopause has been linked to an increased risk for the development of Alzheimer's disease (AD) in women...
  99. ncbi Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells
    Ping Yin
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 92:4459-66. 2007
    ..b>Progesterone stimulates their growth, whereas treatment with progesterone receptor (PR) antagonists or selective ..
  100. ncbi Neuroprotective actions of sex steroids in Parkinson's disease
    Mélanie Bourque
    Molecular Endocrinology and Genomic Research Center, Laval University Medical Center, CHUL, Quebec City, Quebec, Canada
    Front Neuroendocrinol 30:142-57. 2009
    ..This paper reviews the protective effects of sex hormones, particularly estradiol, progesterone and androgens, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of Parkinson's disease ..
  101. ncbi PIBF: the double edged sword. Pregnancy and tumor
    Julia Szekeres-Bartho
    Department of Medical Microbiology and Immunology, Medical School, Pecs University, H 7643 Pecs, Hungary
    Am J Reprod Immunol 64:77-86. 2010
    The role of progesterone-dependent immunomodulation in the maintenance of normal pregnancy.

Research Grants77

  1. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..graduate research utilized sheep as an experimental model to study mechanisms controlling the synthesis of progesterone (P4) by the corpus luteum (CL). During this experience, Dr...
  2. 5-HT transporter function: Interaction of hormones and antidepressants
    Alan Frazer; Fiscal Year: 2013
    ..of in vivo chronoamperometry, that acute administration of ovarian hormones (estradiol benzoate (EB) or progesterone (P)), either given systemically or locally into the CA3 region of the hippocampus, interferes with the ability ..
  3. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..One neurosteroid is progesterone, a classic sex hormone involved in the regulation of reproduction...
  4. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..kinase A (PKA) signaling events initiated by LH, and to determine how these novel mechanisms contribute to progesterone synthesis...
  5. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..safety and efficacy pilot studies will be conducted in another SIV/HIV vaginal transmission animal model: the progesterone-treated macaque model...
  6. Understanding Pain of Gastrointestinal Origin in Women that Serve in OEF/OIF
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..estrous cycle with the luteal phase being associated with visceral hypersensitivity and that elevated levels of progesterone and/or estradiol on the amygdala lead to heightened responsiveness to colorectal distension...
  7. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..will measure 1) the concentrations of luteinizing hormone, follicle-stimulating hormone, E2, pregnenolone (P5), progesterone (P4) and T in matched plasma, CSF and hippocampus from 200 AD and age-matched control brains...
  8. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2010
    ..miRNA analysis in a large collection of triple negative (HER2 gene amplification, Estrogen Receptor (ER), and Progesterone Receptor (PR) negative) and other types of breast tumors in collaboration with Marc van de Vijver at the ..
  9. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..Induction of lordosis in ovariectomized females rats using a sequential DHED and progesterone treatment will test the central activity of DHED...
  10. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..the menopause is a marked attenuation in the production and release of ovarian steroids, such as estradiol and progesterone. However, the impact of these changes on human physiology, especially within the central nervous system (CNS), ..
  11. Endocrine Targets for Prevention of Lung Cancer
    Robert M Bigsby; Fiscal Year: 2012
    ..Considering the interplay between estrogen and progesterone in cancers of other organs, it is likely that progesterone is the ovarian tumor progression factor...
  12. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ..reprotoxicity has yet to be addressed in animal studies and because bulk Cd: is an endocrine disruptor;reduces progesterone levels;alters placental steroidogenesis;can concentrate in the placenta;and, exposure to bulk Cd is associated ..
  13. Apoptosis and Trophoblast Fusion
    NEAL STEWART ROTE; Fiscal Year: 2010
    ..is to investigate the role of these caspases in villous cytotrction of hCG to maintain production of progesterone by the corpus luteum early in pregnancy and transport of gasses, nutrients and maternal protective antibodies ..
  14. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..b>Progesterone (P) is thought to be the major regulator of GnRH synthesis and secretion...
  15. Neuroendocrine Contribution to Behavior &Cognition in the Female Lifespan
    C NEILL NEILL EPPERSON; Fiscal Year: 2013
    ..While 1H-MRS as a tool is excellent for exploring the interaction between progesterone (via allopregnanolone) and GABA, it is not the appropriate technology for questions related to estrogen and ..
  16. RCT of exercise on aromatase inhibitor side effects in breast cancer survivors
    Melinda L Irwin; Fiscal Year: 2012
    ..provided by applicant): Two thirds of all breast cancers diagnosed in US women express estrogen and/or progesterone receptors...
  17. Genomic actions of progesterone receptors in human myometrial cells
    Sam Mesiano; Fiscal Year: 2010
    ..our research focuses on understanding the hormonal control of labor and in particular how the steroid hormone progesterone acting through the nuclear progesterone receptors (nPRs) PR-A and PR-B, controls uterine contractility...
  18. microRNAs as novel biomarkers for management of breast cancer
    LORENZO SEMPERE; Fiscal Year: 2012
    ..The activation status of the Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal growth factor Receptor-like 2 (HER2) are the main diagnostic and prognostic ..
  19. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry J Thompson; Fiscal Year: 2013
    ..be initiated with the objective of identifying subcategories of tumors (initially categorized by estrogen and progesterone receptor status and Her-2/Neu expression) that regress in response to PA;mechanisms that account for regression ..
  20. Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine Disease
    Thomas J Meade; Fiscal Year: 2013
    ..b>Progesterone and estrogen are steroid hormones that bind to their receptors and function as a transcription factors in the ..
  21. Development of transformed lactobacilli as a microbicide
    Richard B Markham; Fiscal Year: 2010
    ..the purpose of demonstrating proof of principle in mouse model systems that require pre-treatment of mice with progesterone. Lactobacillus rhamnosus GR-1 will be used in a mouse model that does not require progesterone pre-treatment, ..
  22. Inhibiting EGFR and ER pathways in NSCLC
    Edward B Garon; Fiscal Year: 2013
    ..collected as part of the clinical trial for correlative secondary endpoints, including tumor levels of ER, ER, progesterone receptor, aromatase and EGFR as well as EGFR mutations and other selected biologic markers...
  23. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010
    ..An essential mediator of this process is the steroid hormone progesterone. Knockout studies have identified several progesterone-regulated genes that contribute are necessary for ..
  24. Transcranial Magnetic Stimulation in Pregnant Women with Depressive Disorder
    Deborah Kim; Fiscal Year: 2013
    ..will measure maternal serum brain derived neurotrophic factor (BDNF) and correlate it with levels of estradiol, progesterone, allopregnanolone, oxytocin and corticotrophin-releasing hormone (CRH) levels pre and post-rTMS...
  25. PROGESTIN AND GROWTH FACTOR CROSS-TALK IN BREAST CANCER
    CAROL ANN LANGE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The ovarian steroid hormones, estrogen and progesterone, promote accumulation of genetic changes during the development of breast cancers, and drive the growth of established breast cancer...
  26. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
    ..Groups include gonadectomized female rats treated with EB, progesterone, EB+progesterone or oil, and also gonadally intact female rats treated with EB or oil...
  27. Neonatal Programming of Growth and Maturation in Rhesus Monkeys
    Andrew Muir; Fiscal Year: 2013
    ..IGF-1) and body composition (DEXA), skeletal (X-ray) and pubertal maturation (physical examination, serum progesterone), and measures of metabolically dysregulated adipose tissue, including insulin resistance (HOMA-IR, glucose ..
  28. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2013
    ..Recent evidence suggests that specific genomic progesterone receptor isoforms (PGR-A and -B) regulate different activities in target tissue;and the discovery of nongenomic ..
  29. Sex and Stress Mechanisms of Vulnerability to Addiction
    Rajita Sinha; Fiscal Year: 2011
    ..We will examine how sensitivity is related to estrus cycle and determine the role of estrogen and progesterone on cocaine-induced VTA CRF responses. Both cue- and stress-induced relapse will be investigated...
  30. Integration of PR and FoxO Signaling in Pituitary Gonadotropes
    Varykina G Thackray; Fiscal Year: 2010
    ..stimuli, she proposes to study whether metabolism and fertility are connected at this level by integration of progesterone receptor (PR) and forkhead (FoxO) signaling...
  31. A twin study of ovarian hormones and disordered eating
    Kelly L Klump; Fiscal Year: 2012
    ..Radioimmunoassay will be used to analyze estradiol, and enzymeimmunoassay will be used to analyze progesterone. Dynamical systems models will examine the extent to which changes in ovarian hormones predict changes in binge ..
  32. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    Howard D Strickler; Fiscal Year: 2012
    ..with: (i) fasting serum levels of insulin, total and free IGF-I, IGF-II, IGFBP-1 and -3, estradiol, estrone, progesterone and sex hormone binding globulin (SHBG);(ii) tumor expression of IGF-I, IGF-II, IGFBP-1 and -3 mRNA (based on ..
  33. Fatty Acid Synthase:Molecular Target for Breast Cancer Therapy &Chemoprevention
    Ruth Lupu; Fiscal Year: 2013
    ..Receptor positive (ER+), HER2 3+ overexpressing (HER2+) and triple negative (TN) [which do not express ER, Progesterone Receptor (PgR), and HER2+)...
  34. BRCA1 and progesterone receptors in breast cancer
    Eva Y Lee; Fiscal Year: 2013
    ..A cross interaction between BRCA1 and nuclear hormone receptors including estrogen and progesterone receptors provides a potential window to address the tissue (mammary epithelial cells)-specific issue...
  35. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..e., the ability to synthesize progesterone and estradiol). Isolated rhesus macaque cumulus-oocyte complexes (COCs) from non-luteinized follicles (i.e...
  36. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    Joanne E Fortune; Fiscal Year: 2010
    ..of this R21 application: that steroids produced by the fetal bovine ovary, particularly estradiol and progesterone, regulate both follicle formation and the competence of follicles to be activated...
  37. Molecular Analysis of NeoAdjuvant Platinum in Triple Negative Breast Cancer
    MARK DANIEL contact PEGRAM; Fiscal Year: 2010
    ..Triple-negative breast cancer (TNBC), defined by lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2), accounts for 15-20% of all breast cancers ..
  38. Depression, Estrogen Replacement, and Cardiovascular Health in the Perimenopause
    David R Rubinow; Fiscal Year: 2013
    ..will then be randomized to either transdermal 172-E2 (100ug/day) or placebo for 12 months, and micronized progesterone (P) will be given every 3 months to women on active ERT (placebo P given on 2 out of 3 months) and placebo P ..
  39. Role of mineralocorticoid receptor in primate ovarian function
    CHARLES CHAFFIN; Fiscal Year: 2009
    ..CYP21A2 converts progesterone to the potent mineralocorticoid receptor (MR) agonist 11-deoxycorticosterone (DOC), and thus correlates with ..
  40. The baroreflex in pregnancy: effects of adrenal and placental steroids
    Maureen Keller-Wood; Fiscal Year: 2012
    ..We further hypothesize that these effects are modulated by progesterone and estradiol, and that the vulnerability of the late gestation pregnant ewe to decreases in plasma cortisol is ..
  41. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network
    Edward K Chien; Fiscal Year: 2013
    ..important understanding regarding prediction and prevention of preterm birth (Preterm Prediction Study, 17-OH progesterone in singletons, twins, and triplets, omega-3 supplements, antibiotics for asymptomatic bacterial vaginosis and T...
  42. HORMONAL INFLUENCES ON AIRWAY DISEASE
    Raksha Jain; Fiscal Year: 2013
    ..Accordingly, the goal of this proposal is to determine the impact of sex hormones, specifically progesterone, on mucociliary clearance, as a basis of explanation for the gender disparity in airways diseases...
  43. Modifiable lifestyle-related factors and triple negative breast cancer prognosis
    SARAH JEAN NECHUTA; Fiscal Year: 2013
    ..provided by applicant): Triple negative breast cancers (TNBCs) are defined as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) negative...
  44. Steroid regulation of glucose utilization during early pregnancy.
    ANTONINA I FROLOVA; Fiscal Year: 2010
    ..differentially modulates glucose uptake by regulating the expression of specific glucose transporters in the progesterone-primed endometrial stromal cells...
  45. Progesterone &Estrogen Differentially Regulate DC Function in Lupus Autoimmunity
    Grant Hughes; Fiscal Year: 2012
    ..1) nine out of ten patients are female;2) SLE patients show increased estrogen (E) activity and decreased progesterone (Pg) and androgen activity;3) in SLE animal models, disease is exacerbated by E;and 4) E has direct stimulatory ..
  46. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2013
    ..of in vivo chronoamperometry, that acute administration of ovarian hormones (estradiol benzoate (EB) or progesterone (P)) impacts the ability of selective serotonin reuptake inhibitors (SSRIs) to alter the function of what is ..
  47. The Effects of Estradiol on Genetic Risk for Disordered Eating During Puberty
    Kelly L Klump; Fiscal Year: 2013
    ..e., progesterone, luteinizing hormone, follicle stimulating hormone, physical changes of puberty, body weight and adiposity) ..
  48. Defining the CD44-STAT3 axis in the pathogenesis of triple-negative breast cancer
    JENNIFER ELYNN YEH; Fiscal Year: 2013
    ..provided by applicant): Triple-negative breast cancers (TNBCs), which do not express estrogen receptor or progesterone receptor or overexpress human epidermal growth factor-related 2 (HER2), are clinically aggressive tumors ..
  49. A Novel IgE Cancer Therapeutic Specific for the Epithelial Membrane Protein-2
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..overexpressed on a large number of breast cancer cells and its expression is independent of estrogen receptor, progesterone receptor, and HER2/neu status, making it an especially meaningful target for a generalized therapy...
  50. c-Abl-mediated Suppression of Breast Cancer Development and Metastasis
    WILLIAM SCHIEMANN; Fiscal Year: 2013
    ..TNBCs are also noteworthy by their failure to express hormone receptors (estrogen and progesterone) and ErbB2/HER2, a phenotype that renders targeted chemotherapies (e.g...
  51. Targeted Therapy of Triple Negative Breast Cancer Using Theranostic Nanoparticles
    Lily Yang; Fiscal Year: 2013
    ..TNBC lacks expression of estrogen (ER), progesterone (PR) and Her-2/neu...
  52. Estrogen and hippocampal plasticity
    LORI LYNN MCMAHON; Fiscal Year: 2012
    ..The Women's Health Initiative (WHI) reported in 2003-2004 that hormone replacement therapy, either progesterone and estrogen in combination or estrogen alone, provided no cardiovascular or cognitive benefit in ..
  53. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2011
    ..We support this aim with preliminary data that GnRH pulses from GT1 cells are regulated by estrogen and progesterone in vitro...
  54. Preventing Anthracycline Cardiovascular Toxicity with Statins
    William Gregory Hundley; Fiscal Year: 2013
    ..Anth-bC) myocardial injury experienced during and after treatment for triple negative (estrogen, progesterone, HER-2 receptor negative) breast cancer...
  55. Genomewide Determinants Of Prognosis And Treatment Of Early-Onset Breast Cancer
    Habibul Ahsan; Fiscal Year: 2010
    ..cancer is disproportionately worse for early-onset cases, who are more likely to be negative for estrogen and progesterone receptors and present with higher grade tumors and advanced stage disease...
  56. Regulation of CD4+ T cell responses by a progesterone receptor
    Grant Hughes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Modulation of inflammation and adaptive immunity by a progesterone receptor Female sex steroids like progesterone (Pg) are powerful modulators of the immune system...
  57. Targeting Adenovirus for Gene Therapy of Uterine Leiomyoma
    Ayman Al-Hendy; Fiscal Year: 2013
    ..effective in local ablation of fibroid lesions;dominant negative estrogen receptor (DN-ER), dominant negative progesterone receptor (DN- PR) or thymidine kinase/ganciclovir (TK/GCV) approach...
  58. Exploiting synthetic-lethal interactions to target triple-negative breast cancers
    Dai Horiuchi; Fiscal Year: 2013
    ..not overexpress human epidermal growth factor receptor 2 (HER2) and lacks the expression of the estrogen and progesterone receptors...
  59. Regulation of miRNA in breast cancer
    Carolyn M Klinge; Fiscal Year: 2013
    ..concordance with other well-established markers of breast cancer stage and patient prognosis including ER1 and progesterone receptor, tumor stage, number of positive lymph nodes, and vascular invasion...
  60. Role of Phospho-Progesterone Receptors (PR) in Hormone Refractory Breast Cancer
    CAROL ANN LANGE; Fiscal Year: 2013
    ..However, progesterone receptors (PR) may also play a key role as mediators of early breast cancer progression...
  61. Impact of Pregnancy on Drug Absorption, Disposition and End Organ Response
    Steve N Caritis; Fiscal Year: 2013
    ..which also express the polymorphisms of interest in CYP, 2C9 and 2D6 and challenge them with estrogen and progesterone to determine the hormone's effects...
  62. Anxiety Sensitivity, Menstrual Cycle Phase, and Panic-Relevant Responding
    Yael Nillni; Fiscal Year: 2011
    ..Cycle phase will be estimated by day count and ovulation kits and confirmed via progesterone assay...
  63. Medications Development for the Pregnant Opiate Addict
    Mahmoud S Ahmed; Fiscal Year: 2010
    ..The activity of aromatase and P-gp are affected by placental genotype and gestational age. Progesterone is an allosteric regulator of P-gp activity...
  64. PREGNANCY & HORMONE EFFECTS ON KIDNEY & URINARY TRACT
    Linda Shortliffe; Fiscal Year: 1999
    ..and urinary tract changes associated with pregnancy, the post-partum period, and alterations in estrogen and progesterone levels will be defined...
  65. HETEROGENEITY OF ESTROGEN RECEPTOR STRUCTURE AND ACTION
    Beth Schachter; Fiscal Year: 1993
    ..Additional correlations with the variant genotype in the breast tumor samples include a lower estrogen receptor/progesterone receptor ratio and a higher progesterone receptor affinity for its steroid...
  66. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    Sandra Carson; Fiscal Year: 1990
    ..Medicine Network provide the opportunity to investigate definitively with sufficient power the role of progesterone deficiency (LPD) in the etiology of spontaneous abortion...
  67. Neuroactive Steroids and Seizure Control during Pregnancy in Women with Epilepsy
    PAGE BUCKHANNAN PENNELL; Fiscal Year: 2010
    ..During pregnancy, the sex steroid hormones estradiol and progesterone increase dramatically...
  68. CGMP PROTEIN KINASE IN PREGNANT MYOMETRIUM
    Trudy Cornwell; Fiscal Year: 2000
    ..protein kinase (cG-kinase) in the normal uterus and how cGMP signaling through this enzyme is modified by progesterone. Cyclic GMP is a second messenger best known for its role as a vasorelaxant...
  69. EXTRAADRENAL MINERALOCORTICOSTEROID FORMATION-METABOLISM
    M Casey; Fiscal Year: 1992
    ..a potent steroid hormone in extraglandular tissues is the biosynthesis of deoxycorticosterone (DOC) from plasma progesterone. It also is recognized that biologically active steroid hormones may be formed in situ in tissue sites of ..
  70. NOVEL ROLE AND REGULATION OF UTERINE TIMPS
    Warren Nothnick; Fiscal Year: 2000
    ..tissue during the reproductive cycle, that these patterns of expression are modulated by estradiol and/or progesterone, and that the steroid-induced expression of TIMP-3 is mediated at least in part through TIMP-1...
  71. REGULATORY MECHANISMS OF OVARIAN PROGESTERONE RECEPTORS
    Ok Kyong Park Sarge; Fiscal Year: 2000
    ..Dr Park-Sarge's research has focused on the regulatory mechanisms of the progesterone receptor gene in tahe ovary...
  72. PROGESTERONE AND ESTROGEN ON SIV VAGINAL TRANSMISSION
    Preston Marx; Fiscal Year: 2007
    b>Progesterone and estrogen have opposing effects on vaginal physiology. Estrogen promotes vaginal epithelial maturation and decreases pH, while progesterone is an estrogen antagonist...
  73. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
    ..b>Progesterone acts to oppose the effects of estrogen on cell proliferation and, consequently, it is used in the treatment of ..
  74. Sex Steroids, and TMJ Pain
    Larry Bellinger; Fiscal Year: 2009
    ..Our central hypothesis is that changes in physiological estrogen, progesterone and testosterone concentrations modulates acute pain as modeled in the TMJ through action at peripheral tissue(..
  75. IN VIVO REGULATION OF STAR IN THE HUMAN CORPUS LUTEUM
    JEROME STRAUSS; Fiscal Year: 2003
    The synthesis of progesterone by the corpus luteum is required for the establishment of human pregnancy...
  76. STEROID CONTROL OF UTERINE VASCULAR FUNCTION
    RONALD MAGNESS; Fiscal Year: 1999
    ..flow (UBF) increases during the follicular phase of the estrous cycle when the systemic and local estrogen/progesterone ratio is elevated. In the nonpregnant sheep...
  77. BRAIN OXYTOCIN RECEPTORS--FUNCTION AND STRUCTURE
    LORETTA FLANAGAN CATO; Fiscal Year: 2001
    ..receptors (OTRs) in the hypothalamus facilitate female sexual behavior after pretreatment with estradiol and progesterone. Estradiol appears important for enhancing the level of mRNA for this protein...