vasoactive intestinal peptide

Summary

Summary: A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).

Top Publications

  1. pmc Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension
    Ventzislav Petkov
    Department of Internal Medicine, University of Vienna, Medical School, Vienna, Austria
    J Clin Invest 111:1339-46. 2003
  2. pmc Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons
    Sara J Aton
    Department of Biology, One Brookings Drive, Washington University, St Louis, Missouri 63130, USA
    Nat Neurosci 8:476-83. 2005
  3. ncbi Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis
    V S Conlin
    Division of Gastroenterology, Child and Family Research Institute, BC Children s Hospital, Vancouver, BC, Canada
    Am J Physiol Gastrointest Liver Physiol 297:G735-50. 2009
  4. ncbi Mice lacking the VIP gene show airway hyperresponsiveness and airway inflammation, partially reversible by VIP
    Anthony M Szema
    Department of Medicine, State University of New York at Stony Brook, NY 11794 8172, USA
    Am J Physiol Lung Cell Mol Physiol 291:L880-6. 2006
  5. ncbi The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei
    Anthony J Harmar
    Department of Neuroscience, University of Edinburgh, 1 George Square, United Kingdom
    Cell 109:497-508. 2002
  6. ncbi Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections
    E E Abrahamson
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Brain Res 916:172-91. 2001
  7. pmc Immunochemical characterization of inhibitory mouse cortical neurons: three chemically distinct classes of inhibitory cells
    Xiangmin Xu
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 518:389-404. 2010
  8. pmc Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1
    Anthony J Harmar
    University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 166:4-17. 2012
  9. pmc Serotonin 3A receptor subtype as an early and protracted marker of cortical interneuron subpopulations
    Ksenija Vucurovic
    CNRS UMR 7637, Laboratoire de Neurobiologie, ESPCI ParisTech, 75005 Paris, France
    Cereb Cortex 20:2333-47. 2010
  10. ncbi VPAC and PAC receptors: From ligands to function
    Louise Dickson
    Centre for Integrative Physiology, University of Edinburgh, EH8 9XD, UK
    Pharmacol Ther 121:294-316. 2009

Detail Information

Publications294 found, 100 shown here

  1. pmc Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension
    Ventzislav Petkov
    Department of Internal Medicine, University of Vienna, Medical School, Vienna, Austria
    J Clin Invest 111:1339-46. 2003
    ..We describe a new concept for treatment of the disease using vasoactive intestinal peptide, a neuropeptide primarily functioning as a neurotransmitter that acts as a potent systemic and ..
  2. pmc Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons
    Sara J Aton
    Department of Biology, One Brookings Drive, Washington University, St Louis, Missouri 63130, USA
    Nat Neurosci 8:476-83. 2005
    ..We conclude that VIP coordinates daily rhythms in the SCN and behavior by synchronizing a small population of pacemaking neurons and maintaining rhythmicity in a larger subset of neurons...
  3. ncbi Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis
    V S Conlin
    Division of Gastroenterology, Child and Family Research Institute, BC Children s Hospital, Vancouver, BC, Canada
    Am J Physiol Gastrointest Liver Physiol 297:G735-50. 2009
    ..Previous in vitro studies demonstrated that the neuropeptide vasoactive intestinal peptide (VIP) regulates epithelial paracellular permeability, and the high concentrations and close proximity ..
  4. ncbi Mice lacking the VIP gene show airway hyperresponsiveness and airway inflammation, partially reversible by VIP
    Anthony M Szema
    Department of Medicine, State University of New York at Stony Brook, NY 11794 8172, USA
    Am J Physiol Lung Cell Mol Physiol 291:L880-6. 2006
    ....
  5. ncbi The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei
    Anthony J Harmar
    Department of Neuroscience, University of Edinburgh, 1 George Square, United Kingdom
    Cell 109:497-508. 2002
    The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are implicated in the photic entrainment of circadian rhythms in the suprachiasmatic nuclei (SCN)...
  6. ncbi Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections
    E E Abrahamson
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Brain Res 916:172-91. 2001
    ..The organization of the mouse SCN, and its connections, are similar to that in other mammalian species...
  7. pmc Immunochemical characterization of inhibitory mouse cortical neurons: three chemically distinct classes of inhibitory cells
    Xiangmin Xu
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 518:389-404. 2010
    ..Taken together, our data reveal important chemical distinctions between mouse inhibitory cortical neurons and indicate that PV, SOM, and VIP can differentially label a majority of mouse inhibitory cortical neurons...
  8. pmc Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1
    Anthony J Harmar
    University of Edinburgh, Edinburgh, UK
    Br J Pharmacol 166:4-17. 2012
    b>Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are members of a superfamily of structurally related peptide hormones that includes glucagon, glucagon-like peptides, secretin, gastric ..
  9. pmc Serotonin 3A receptor subtype as an early and protracted marker of cortical interneuron subpopulations
    Ksenija Vucurovic
    CNRS UMR 7637, Laboratoire de Neurobiologie, ESPCI ParisTech, 75005 Paris, France
    Cereb Cortex 20:2333-47. 2010
    ..The first population was characterized by the frequent expression of the vasoactive intestinal peptide and a typical bipolar/bitufted morphology, whereas the second population expressed predominantly the ..
  10. ncbi VPAC and PAC receptors: From ligands to function
    Louise Dickson
    Centre for Integrative Physiology, University of Edinburgh, EH8 9XD, UK
    Pharmacol Ther 121:294-316. 2009
    b>Vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase activating polypeptides (PACAPs) share 68% identity at the amino acid level and belong to the secretin peptide family...
  11. ncbi Therapeutic treatment of experimental colitis with regulatory dendritic cells generated with vasoactive intestinal peptide
    Elena Gonzalez-Rey
    Institute of Parasitology and Biomedicine, Consejo Superior de Investigaciones Cientificas, Granada, Spain
    Gastroenterology 131:1799-811. 2006
    ..b>Vasoactive intestinal peptide is an immunomodulatory neuropeptide that induces regulatory DCs...
  12. ncbi The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine
    Serdar Gunaydin
    Department of Pediatric Cardiac Surgery, Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
    Cardiovasc Surg 10:138-45. 2002
    b>Vasoactive intestinal peptide (VIP) has regulatory effects on myocardial and vasomotor functions usually demonstrated by in vitro or isolated heart studies...
  13. ncbi Disrupted circadian rhythms in VIP- and PHI-deficient mice
    Christopher S Colwell
    Mental Retardation Res Ctr, Univ of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Am J Physiol Regul Integr Comp Physiol 285:R939-49. 2003
    The related neuropeptides vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) are expressed at high levels in the neurons of the suprachiasmatic nucleus (SCN), but their function in the regulation of circadian ..
  14. ncbi Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene
    Sami I Said
    Departments of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA
    Circulation 115:1260-8. 2007
    b>Vasoactive intestinal peptide (VIP), a pulmonary vasodilator and inhibitor of vascular smooth muscle proliferation, has been reported absent in pulmonary arteries from patients with idiopathic pulmonary arterial hypertension (PAH)...
  15. ncbi Vasoactive intestinal peptide protects against ischemic brain damage induced by focal cerebral ischemia in rats
    Jie Yang
    Department of Human Anatomy, Histology and Embryology, School of Medicine, Xi an Jiaotong University, Xi an, Shaanxi 710061, China
    Brain Res 1398:94-101. 2011
    b>Vasoactive intestinal peptide (VIP) exerts neuroprotective effects under various neurotoxic conditions in vitro. In the present study, we investigated the effects of VIP on transient ischemic brain damage...
  16. ncbi RNA interference-directed silencing of VPAC1 receptor inhibits VIP effects on both EGFR and HER2 transactivation and VEGF secretion in human breast cancer cells
    Ana Valdehita
    Department of Biochemistry and Molecular Biology, University of Alcala, Alcala de Henares 28871, Spain
    Mol Cell Endocrinol 348:241-6. 2012
    We used small-interference RNA (siRNA) to explore the mechanisms of some vasoactive intestinal peptide (VIP) actions on human breast cancer cells...
  17. ncbi VIP/PACAP preferentially attract Th2 effectors through differential regulation of chemokine production by dendritic cells
    Mario Delgado
    Instituto de Parasitologica y Biomedicina, CSIC, Granada, Spain
    FASEB J 18:1453-5. 2004
    The neuropeptides vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP) are potent immunomodulatory agents, acting as general anti-inflammatory factors...
  18. ncbi Mutations in the carboxy-terminus of the third intracellular loop of the human recombinant VPAC1 receptor impair VIP-stimulated [Ca2+]i increase but not adenylate cyclase stimulation
    Ingrid Langer
    Department of Biological Chemistry and Nutrition, Faculty of Medicine, Universite Libre de Bruxelles, Campus Erasme, Bat G E, 808 route de Lennik CP611, B 1070 Brussels, Belgium
    Cell Signal 17:17-24. 2005
    ..Thus, the interaction of different G proteins with the VPAC1 receptor involves different receptor sub-domains...
  19. ncbi Characterization of a G protein coupling "YL" motif of the human VPAC1 receptor, equivalent to the first two amino acids in the "DRY" motif of the rhodopsin family
    J W Tams
    Department of Clinical Biochemistry, Novozymes A S, Bagsvaerd, Denmark
    J Mol Neurosci 17:325-30. 2001
    ..By comparing vasoactive intestinal peptide (VIP) binding with or without the presence of GTP-gamma-S, it was found that the deltadelta G(o) for ..
  20. ncbi Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor
    S P Sreedharan
    Department of Medicine, University of California, San Francisco 94143 0724
    Biochem Biophys Res Commun 193:546-53. 1993
    b>Vasoactive intestinal peptide (VIP) is a potent mediator of gastrointestinal, nervous, pulmonary, vascular and immune functions...
  21. pmc Effects of vasoactive intestinal peptide genotype on circadian gene expression in the suprachiasmatic nucleus and peripheral organs
    Dawn H Loh
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    J Biol Rhythms 26:200-9. 2011
    ....
  22. pmc A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits
    Elizabeth S Maywood
    Division of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 108:14306-11. 2011
    ..is sufficient to restore cellular synchrony and amplitude of pacemaking in SCN circuits lacking vasoactive intestinal peptide (VIP)...
  23. ncbi Vasoactive intestinal peptide protects against beta-amyloid-induced neurodegeneration by inhibiting microglia activation at multiple levels
    Mario Delgado
    Instituto de Parasitologia y Biomedicina, CSIC, Granada, Spain
    Glia 56:1091-103. 2008
    ..The vasoactive intestinal peptide (VIP), a widely distributed neuropeptide, has shown neuroprotective effects in acute brain damage in ..
  24. ncbi Enhancement of pulmonary vascular remodelling and inflammatory genes with VIP gene deletion
    S A Hamidi
    Pulmonary and Critical Care Medicine, State University of New York Health Sciences Center, Stony Brook, NY 11784 8172, USA
    Eur Respir J 31:135-9. 2008
    ..The present authors recently reported that mice with vasoactive intestinal peptide (VIP) gene disruption show a spontaneous phenotype of PAH, with pulmonary vascular remodelling and ..
  25. ncbi Vasoactive intestinal peptide (VIP) induces malignant transformation of the human prostate epithelial cell line RWPE-1
    Ana B Fernández-Martínez
    Department of Biochemistry and Molecular Biology, University of Alcala, 28871 Alcala de Henares, Spain
    Cancer Lett 299:11-21. 2010
    The carcinogenic potential of vasoactive intestinal peptide (VIP) was analyzed in non-tumor human prostate epithelial cells (RWPE-1) and in vivo xenografts...
  26. ncbi Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease
    Catalina Abad
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    Gastroenterology 124:961-71. 2003
    ..b>Vasoactive intestinal peptide (VIP) has recently emerged as a promising candidate for treatment of inflammatory Th1-driven diseases...
  27. ncbi The significance of vasoactive intestinal peptide in immunomodulation
    Mario Delgado
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Calle Ventanilla 11, Granada 18001, Spain
    Pharmacol Rev 56:249-90. 2004
    First identified by Said and Mutt some 30 years ago, the vasoactive intestinal peptide (VIP) was originally isolated as a vasodilator peptide...
  28. ncbi The innervation of parvalbumin-containing interneurons by VIP-immunopositive interneurons in the primary somatosensory cortex of the adult rat
    Csaba David
    Albert Ludwigs University Freiburg, Institute of Anatomy and Cell Biology, Department of Neuroanatomy, D 79001 Freiburg, Germany
    Eur J Neurosci 25:2329-40. 2007
    ..Together with metabolic and neuromodulatory effects of VIP, this would probably result in an enhanced responsiveness of the latter cell type to tactile stimuli...
  29. ncbi 5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons
    Isabelle Ferezou
    Laboratoire de Neurobiologie et Diversité Cellulaire, Centre National de la Recherche Scientifique, Unité Mixte de Rechérche 7637, Ecole Superieure de Physique et Chime Industrielles de la ville de Paris, 75005 Paris, France
    J Neurosci 22:7389-97. 2002
    ..was expressed selectively in a subset of GABAergic interneurons coexpressing cholecystokinin (CCK) and vasoactive intestinal peptide (VIP)...
  30. pmc Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders
    Alejo Chorny
    Institute of Parasitology and Biomedicine, Consejo Superior de Investigaciones Cientificas, 18100 Granada, Spain
    Proc Natl Acad Sci U S A 102:13562-7. 2005
    ..In this study, we report on the use of the known immunosuppressive neuropeptide, the vasoactive intestinal peptide, as a new approach to induce tolerogenic DCs with capacity to generate Tr cells, to restore tolerance ..
  31. pmc Emerging roles of vasoactive intestinal peptide: a new approach for autoimmune therapy
    Elena Gonzalez-Rey
    Departamento de Bioquimica Medica y Biologia Molecular, Universidad de Sevilla, Servilla, Spain
    Ann Rheum Dis 66:iii70-6. 2007
    ..Among them, the vasoactive intestinal peptide (VIP), a well-characterised endogenous anti-inflammatory neuropeptide, has shown therapeutic potential ..
  32. ncbi Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation
    Rose Claire St Hilaire
    Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Peptides 31:1517-22. 2010
    Recent studies have suggested the potential use of vasoactive intestinal peptide (VIP) in the treatment of pulmonary arterial hypertension (PAH)...
  33. pmc Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression
    Bronwen Martin
    National Institutes of Health, National Institute on Aging, Baltimore, Maryland, USA
    Diabetes 59:1143-52. 2010
    ..evidence implicates gut-related hormones in taste perception, including glucagon-like peptide 1 and vasoactive intestinal peptide (VIP)...
  34. ncbi Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats
    T Rudholm
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden
    Regul Pept 152:8-12. 2009
    ..solutions on the release of the inhibitory gut peptides somatostatin (SOM), neurotensin (NT) and vasoactive intestinal peptide (VIP) was studied in conscious rats during pentagastrin-stimulated gastric acid secretion...
  35. ncbi Inhibition of CD26/DPP IV attenuates ischemia/reperfusion injury in orthotopic mouse lung transplants: the pivotal role of vasoactive intestinal peptide
    Wolfgang Jungraithmayr
    Division of Thoracic Surgery, University Hospital of Zurich, Raemistr 100, 8091 Zurich, Switzerland
    Peptides 31:585-91. 2010
    ..Furthermore, preservation of endogenous intragraft VIP levels correlate with maintaining lung function and structural integrity...
  36. ncbi Serum levels of vasoactive intestinal peptide (VIP) in patients with adenocarcinomas of the gastrointestinal tract
    M Hejna
    Division of Oncology, University of Vienna, Austria
    Anticancer Res 21:1183-7. 2001
    ..CONCLUSIONS: As opposed to pancreatic cancer and healthy controls, patients in our series had elevated serum VIP-levels. Further studies are warranted to evaluate whether VIP can be used as a tumor marker in this disease...
  37. pmc Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal NTera2 cells
    Jinxiang Yuan
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Virol 83:6391-403. 2009
    ..HCMV-infected human pluripotent embryonal NTera2 cells (NT2) to model HCMV reactivation, we show that vasoactive intestinal peptide (VIP), an immunomodulatory neuropeptide, immediately and dose-dependently (1 to 500 nM) activates HCMV ..
  38. ncbi Immunology of VIP: a review and therapeutical perspectives
    R P Gomariz
    Dept Cell Biology, Faculty of Biology, Complutense University, Madrid 28040, Spain
    Curr Pharm Des 7:89-111. 2001
    b>Vasoactive intestinal peptide (VIP) is a neuropeptide with a broad distribution in the body that exerts very important pleiotropic functions in several systems. The present work reviews the immunology of VIP...
  39. ncbi Vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide receptor subtypes in mouse calvarial osteoblasts: presence of VIP-2 receptors and differentiation-induced expression of VIP-1 receptors
    P Lundberg
    Department of Odontology, Oral Cell Biology, Umea University, Umea, Sweden
    Endocrinology 142:339-47. 2001
    Three distinct complementary DNAs for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors have been cloned and designated VIP-1 receptor (VIP-1R), VIP-2 receptor (VIP-2R), and PACAP ..
  40. pmc Pharmacological inhibition of VIP signaling enhances antiviral immunity and improves survival in murine cytomegalovirus-infected allogeneic bone marrow transplant recipients
    Jian Ming Li
    Department of Hematology Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Blood 121:2347-51. 2013
    ..b>Vasoactive intestinal peptide (VIP) suppresses Th1 immunity...
  41. pmc Molecular and electrophysiological characterization of GFP-expressing CA1 interneurons in GAD65-GFP mice
    Corette J Wierenga
    Department of Cellular and Systems Neurobiolgy, Max Planck Institute of Neurobiology, Martinsried, Germany
    PLoS ONE 5:e15915. 2010
    ..The majority of them expresses either reelin (70±2%) or vasoactive intestinal peptide (VIP; 15±2%), while expression of parvalbumin and somatostatin is virtually absent...
  42. ncbi Vasoactive intestinal peptide antagonist retards the development of neonatal behaviors in the rat
    J M Hill
    Peptide Design, Germantown, MD 20874
    Peptides 12:187-92. 1991
    ..Cotreatment with VIP prevented the antagonist-induced delay. These results suggest that VIP activity is important in the development of select complex motor behaviors...
  43. pmc Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions
    Mario Delgado
    Instituto de Parasitologia y Biomedicina, IPBLN CSIC, Granada, Spain
    Amino Acids 45:25-39. 2013
    b>Vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide/neurotransmitter, is widely distributed in both the central and peripheral nervous system. VIP is released by both neurons and immune cells...
  44. ncbi Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38)
    A Miyata
    U S Japan Biomedical Research Laboratories, Tulane University Hebert Center, Belle Chasse, LA 70037
    Biochem Biophys Res Commun 170:643-8. 1990
    ..Moreover PACAP27 which shows a considerable homology with vasoactive intestinal polypeptide (VIP) demonstrated a similar vasodepressor activity as VIP, but the adenylate cyclase stimulating activity was about 1000 times greater than VIP...
  45. ncbi Immunomodulatory roles of VIP and PACAP in models of multiple sclerosis
    Catalina Abad
    The Semel Institute for Neuroscience and Human and Department of Psychiatry, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Curr Pharm Des 17:1025-35. 2011
    ..In this review, the immunomodulatory actions of VIP and PACAP will be discussed, with particular emphasis on their potential significance in MS...
  46. ncbi RNA sensors in human osteoarthritis and rheumatoid arthritis synovial fibroblasts: immune regulation by vasoactive intestinal peptide
    Mar Carrión
    Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense de Madrid, and Hospital 12 de Octubre, Madrid, Spain
    Arthritis Rheum 63:1626-36. 2011
    ..An additional goal was to study the effect of vasoactive intestinal peptide (VIP).
  47. ncbi Activation of CFTR trafficking and gating by vasoactive intestinal peptide in human bronchial epithelial cells
    Fei Qu
    Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China
    J Cell Biochem 112:902-8. 2011
    ....
  48. ncbi VPAC1 (vasoactive intestinal peptide (VIP) receptor type 1) G protein-coupled receptor mediation of VIP enhancement of murine experimental colitis
    Mahesh Yadav
    Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
    Cell Immunol 267:124-32. 2011
    Distinct roles of the two T cell G protein-coupled receptors for vasoactive intestinal peptide (VIP), termed VPAC1 and VPAC2, in VIP regulation of autoimmune diseases were investigated in the dextran sodium sulfate (DSS)-induced murine ..
  49. ncbi The vasoactive intestinal peptide receptor turnover in pulmonary arteries indicates an important role for VIP in the rat lung circulation
    Ventzislav Petkov
    Medical University Vienna, KIM 1, Institute of Cancer Research, Borschkegasse 8a, A 1090 Wien, Austria
    Ann N Y Acad Sci 1070:481-3. 2006
    b>Vasoactive intestinal peptide (VIP) is a potent vasorelaxing peptide that plays a role in lung physiology and possibly in pulmonary hypertension. We investigated the turnover of the VIP receptors on rat pulmonary arteries ex vivo...
  50. ncbi Vasoactive intestinal peptide prevents activated microglia-induced neurodegeneration under inflammatory conditions: potential therapeutic role in brain trauma
    Mario Delgado
    Department of Biological Sciences, Rutgers University, Newark, New Jersey, USA
    FASEB J 17:1922-4. 2003
    ..b>Vasoactive intestinal peptide (VIP) is a neuropeptide with a potent anti-inflammatory effect, which has been found to protect from ..
  51. ncbi The vasoactive intestinal peptide-receptor system is involved in human glioblastoma cell migration
    Stéphanie Cochaud
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, CNRS, 40 Avenue du Recteur Pineau, Poitiers F 86022, France
    Neuropeptides 44:373-83. 2010
    ..This cancer has an infiltrative nature and the median survival of patients is about one year. Vasoactive intestinal peptide (VIP) belongs to a structurally related family of polypeptides and is a major regulatory factor in the ..
  52. ncbi Vasoactive intestinal peptide reduces oxidative stress in pancreatic acinar cells through the inhibition of NADPH oxidase
    Nao Fujimori
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Peptides 32:2067-76. 2011
    b>Vasoactive intestinal peptide (VIP) attenuates experimental acute pancreatitis (AP) by inhibition of cytokine production from inflammatory cells...
  53. ncbi Selective responses of myenteric neurons to oxidative stress and diabetic stimuli
    E Voukali
    Department of Cell and Developmental Biology, University College London, Gower Street, London, UK
    Neurogastroenterol Motil 23:964-e411. 2011
    ..Diabetes has a differential effect on different subpopulations of myenteric neurons. Our aim was to investigate an in vitro model to examine the pathways underlying the development of nerve changes in diabetes...
  54. pmc Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis
    Catalina Abad
    The Semel Institute and Department of Psychiatry, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:19555-60. 2010
    The neuropeptide vasoactive intestinal peptide (VIP) has been shown to inhibit macrophage proinflammatory actions, promote a positive Th2/Th1 balance, and stimulate regulatory T-cell production...
  55. ncbi (N-stearyl, norleucine17)VIPhybrid is a broad spectrum vasoactive intestinal peptide receptor antagonist
    Terry W Moody
    National Cancer Institute, Medicine Branch, Rockville, MD 20850, USA
    J Mol Neurosci 18:29-35. 2002
    The effects of a (N-stearyl, Norleucine17) vasoactive intestinal peptide hybrid ((SN)VIPhybrid) on cells stably transfected with VPAC,, VPAC2, or PAC1 receptors were investigated...
  56. ncbi Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide
    P Nicole
    Unité INSERM U410 de Neuroendocrinologie et Biologie Cellulaire Digestives, Faculte de Medecine Xavier Bichat, Paris, 75018, France
    J Biol Chem 275:24003-12. 2000
    The widespread neuropeptide vasoactive intestinal peptide (VIP) has two receptors VPAC(1) and VPAC(2)...
  57. pmc Novel association between vasoactive intestinal peptide and CRTH2 receptor in recruiting eosinophils: a possible biochemical mechanism for allergic eosinophilic inflammation of the airways
    Amr E El-Shazly
    Department of Oto Rhino Laryngology and Head and Neck Surgery, Liege University Hospital Centre hospitalier Universaitaire C H U, 4000 Liege, Belgium
    J Biol Chem 288:1374-84. 2013
    We explored the relation between vasoactive intestinal peptide (VIP), CRTH2, and eosinophil recruitment...
  58. ncbi Neuroprotective potential of three neuropeptides PACAP, VIP and PHI
    Agnieszka Dejda
    Centre for Medical Biology, Polish Academy of Sciences, Lodowa 106, PL 93 232 Łódź, Poland
    Pharmacol Rep 57:307-20. 2005
    Pituitary adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal peptide (VIP) and peptide histidine-isoleucine (PHI), are structurally related endogenous peptides widely expressed in the central and peripheral nervous ..
  59. ncbi Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit chemokine production in activated microglia
    Mario Delgado
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    Glia 39:148-61. 2002
    ..b>Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two structurally related ..
  60. ncbi Signaling mechanisms of vasoactive intestinal peptide in inflammatory conditions
    Alejo Chorny
    Instituto de Parasitologia y Biomedicina, CSIC, Avd Conocimiento, PT Ciencias de la Salud, Granada 18100, Spain
    Regul Pept 137:67-74. 2006
    The vasoactive intestinal peptide (VIP) is a neuropeptide belonging to the secretin/glucagon family of peptides, which exerts a wide spectrum of immunological functions controlling the homeostasis of immune system through different ..
  61. ncbi Vasoactive intestinal peptide family as a therapeutic target for Parkinson's disease
    Elena Gonzalez-Rey
    Instituto de Parasitologia y Biomedicina, CSIC, Avd Conocimiento sn, PT Ciencias de la Salud, Granada, Spain
    Expert Opin Ther Targets 9:923-9. 2005
    ..b>Vasoactive intestinal peptide (VIP), a neuropeptide with a potent anti-inflammatory, antiapoptotic and neurotrophic effect, has been ..
  62. ncbi Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome
    Joanna M Hill
    Section on Developmental and Molecular Pharmacology, NICHD, NIH, Bethesda, MD 20892, USA
    Exp Neurol 183:56-65. 2003
    ..Recent data link vasoactive intestinal peptide malfunction with developmental delays and cognitive deficits...
  63. ncbi 99mTc labeled VIP analog: evaluation for imaging colorectal cancer
    P S Rao
    Thomas Jefferson University, Department of Radiology, Philadelphia, PA, USA
    Nucl Med Biol 28:445-50. 2001
    ..Colorectal cancer cells express Vasoactive Intestinal Peptide (VIP) receptors in high density...
  64. ncbi Vasoactive intestinal peptide balances pro- and anti-inflammatory cytokines in the Pseudomonas aeruginosa-infected cornea and protects against corneal perforation
    Elizabeth A Szliter
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 178:1105-14. 2007
    ..To determine whether vasoactive intestinal peptide (VIP) played a role in development of the resistant response, protein expression levels were tested by ..
  65. ncbi Expression localisation and functional activity of pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal polypeptide and their receptors in mouse ovary
    Marzia Barberi
    Department of Histology and Medical Embriology, La Sapienza University of Rome, Via A Scarpa, 14, Rome 00161, Italy
    Reproduction 134:281-92. 2007
    ..Moreover, the presence of PACAP/VIP receptors in the untreated ovary suggests a possible role for PACAP and VIP during follicle development...
  66. ncbi Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP
    A Couvineau
    Unité de Neuroendocrinologie et Biologie Cellulaire Digestives, INSERM U 410, Faculte de Medecine Xavier Bichat, Paris, France
    Biochem Biophys Res Commun 206:246-52. 1995
    ....
  67. ncbi Inhibition of endotoxin-induced macrophage chemokine production by VIP and PACAP in vitro and in vivo
    M Delgado
    Rutgers University, Newark, NJ, USA
    Arch Physiol Biochem 109:377-82. 2001
    ..Peptides such as vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP), released following antigenic ..
  68. ncbi VIP and PACAP
    Jan Fahrenkrug
    Department of Clinical Biochemistry, Bispebjerg Hospital, Faculty of Health Sciences, University of Copenhagen, 2400, Copenhagen, NV, Denmark
    Results Probl Cell Differ 50:221-34. 2010
    ..All peptides are present in tissue, the dominating form being PACAP 38. Prohormone convertase (PC) 1 and 2 seem to be involved in the processing of PACAP, except in the testes and ovary, where the PACAP precursor is substrate for PC4...
  69. pmc Vasoactive intestinal polypeptide requires parallel changes in adenylate cyclase and phospholipase C to entrain circadian rhythms to a predictable phase
    Sungwon An
    Department of Biology, Washington University, St Louis, MO 63130 4899, USA
    J Neurophysiol 105:2289-96. 2011
    ..We conclude that VIP entrains circadian timing among SCN neurons through rapid and parallel changes in adenylate cyclase and phospholipase C activities...
  70. ncbi Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E
    Ariane Leite Rozza
    Morphology Department, Biosciences Institute, Univ Estadual Paulista, Botucatu, SP, Brazil
    Chem Biol Interact 189:82-9. 2011
    ..CL gastroprotective mechanism is involved with PGE₂. PIN did not present gastroprotective activity...
  71. pmc Absence of vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in mice
    Jian Ming Li
    Department of Hematology Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    J Immunol 187:1057-65. 2011
    b>Vasoactive intestinal peptide (VIP) induces regulatory dendritic cells (DC) in vitro that inhibit cellular immune responses...
  72. pmc Select cognitive deficits in vasoactive intestinal peptide deficient mice
    Dipesh Chaudhury
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 760 Westwood Plaza, Los Angeles, California 90024 1759, USA
    BMC Neurosci 9:63. 2008
    The neuropeptide vasoactive intestinal peptide (VIP) is widely distributed in the adult central nervous system where this peptide functions to regulate synaptic transmission and neural excitability...
  73. ncbi Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activation polypeptide (PACAP) protect mice from lethal endotoxemia through the inhibition of TNF-alpha and IL-6
    M Delgado
    Department of Cellular Biology, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    J Immunol 162:1200-5. 1999
    The neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) down-regulate cytokine production...
  74. ncbi Emerging therapies for the treatment of pulmonary hypertension
    Kurt R Stenmark
    Developmental Lung Biology Laboratory, University of Colorado Denver, Aurora, CO, USA
    Pediatr Crit Care Med 11:S85-90. 2010
    ..Rho kinase inhibitors, vasodilator peptides (such as vasoactive intestinal peptide and adrenomedullin), and endothelial nitric oxide synthase coupling agents (cicletanine) have been ..
  75. pmc Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea
    S Kordasti
    Department of Virology, Swedish Institute for Infectious Disease Control, 172 82 Solna, Sweden
    Gut 53:952-7. 2004
    ..We now report that antagonists for the 5-hydroxytryptamine 3 receptor (5-HT(3)) and vasoactive intestinal peptide (VIP) receptor, but not antagonists for 5-hydroxytryptamine 4 receptor or the muscarinic receptor, ..
  76. pmc Neuropeptides activate human mast cell degranulation and chemokine production
    Marianna Kulka
    National Research Council Canada, Room 432, 550 University Avenue, Charlottetown, PE, Canada
    Immunology 123:398-410. 2008
    ..These results are likely to have direct relevance to neuronally induced inflammatory diseases...
  77. ncbi Vasoactive intestinal peptide fibers innervate neuroendocrine dopaminergic neurons
    L M Gerhold
    Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA
    Brain Res 919:48-56. 2001
    ..Using antibodies directed against vasoactive intestinal peptide (VIP) and tyrosine hydroxylase (TH) the rate-limiting enzyme in dopamine synthesis, fine VIP fibers in ..
  78. ncbi Distribution of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC1, VPAC2, and PAC1 receptor) in the rat brain
    Kyeung Min Joo
    Department of Anatomy, Seoul National University College of Medicine, Seoul 110 799, Korea
    J Comp Neurol 476:388-413. 2004
    ..We hope that this first demonstration of the distributions of the VIP/PACAP receptors provides data useful in the investigation of the mechanisms of the many functions of VIP and PACAP in the brain, which require further elucidation...
  79. pmc Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease
    S G R Smalley
    School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, Leicestershire, UK
    Clin Exp Immunol 157:225-34. 2009
    Since the late 1970s a number of laboratories have studied the role of vasoactive intestinal peptide (VIP) in inflammation and immunity...
  80. pmc VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies
    Terry W Moody
    Department of Health and Human Services, National Cancer Institute Office of the Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Endocrinol Diabetes Obes 18:61-7. 2011
    b>Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) as well as the three classes of G-protein-coupled receptors mediating their effects, are widely distributed in the central nervous system (..
  81. ncbi Corticotropin releasing factor-distribution in rat intestine and role in neuroprotection
    Elin Sand
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Regul Pept 166:68-75. 2011
    ..neurons from rat ileum and to examine if additions of CRF, urocortin 1 (Ucn1), CRF antagonist or vasoactive intestinal peptide (VIP) affect neuronal survival in vitro...
  82. ncbi Vasoactive intestinal peptide and regulatory T-cell induction: a new mechanism and therapeutic potential for immune homeostasis
    Elena Gonzalez-Rey
    Departamento de Bioquimica Medica y Biologia Molecular, Universidad de Sevilla, Sevilla 41009, Spain
    Trends Mol Med 13:241-51. 2007
    ..Recent evidence indicates that vasoactive intestinal peptide (VIP), an anti-inflammatory neuropeptide with therapeutic potential in various immune disorders, ..
  83. ncbi New formulation of vasoactive intestinal peptide using liposomes in hyaluronic acid gel for uveitis
    Laure Lajavardi
    Univ Paris Sud 11, Physico chimie Pharmacotechnie Biopharmacie, Faculte de Pharmacie, F 92296 Chatenay Malabry, France
    J Control Release 139:22-30. 2009
    We evaluated the benefits of a novel formulation of vasoactive intestinal peptide (VIP) based on the incorporation of VIP-loaded rhodamine-conjugated liposomes (VIP-Rh-Lip) within hyaluronic acid (HA) gel (Gel-VIP-Rh-Lip) for the ..
  84. ncbi Vasoactive intestinal peptide (VIP) treatment of Parkinsonian rats increases thalamic gamma-aminobutyric acid (GABA) levels and alters the release of nerve growth factor (NGF) by mast cells
    Orhan Tansel Korkmaz
    Department of Physiology, Medical Faculty, Eskisehir Osmangazi University, 26480, Eskisehir, Turkey
    J Mol Neurosci 41:278-87. 2010
    ..In a previous study, we found that systemically administered vasoactive intestinal peptide (VIP) was effective at reversing the motor deficits (but not the decline in striatal dopamine levels) ..
  85. ncbi Inhibition of endotoxin-induced macrophage chemokine production by vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide in vitro and in vivo
    M Delgado
    Department of Biological Sciences, Rutgers University, 101 Warren Street, Newark, NJ 07102, USA
    J Immunol 167:966-75. 2001
    ..Neuropeptides such as vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP), released after antigenic ..
  86. pmc Vasoactive intestinal peptide is critical for circadian regulation of glucocorticoids
    Dawn H Loh
    Semel Institute for Neuroscience, Mental Retardation Research Center, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Calif 90024 1759, USA
    Neuroendocrinology 88:246-55. 2008
    ..A variety of recent evidence indicates that the neuropeptide vasoactive intestinal peptide (VIP) is critical for normal functioning of the SCN...
  87. ncbi c-Maf and JunB mediation of Th2 differentiation induced by the type 2 G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide
    Julia Voice
    Departments of Medicine and Microbiology Immunology, Medical Center, University of California San Francisco, 533 Parnassus at 4th, San Francisco, CA 94143, USA
    J Immunol 172:7289-96. 2004
    b>Vasoactive intestinal peptide and its G protein-coupled receptors, VPAC(1) and VPAC(2), regulate critical aspects of innate and adaptive immunity...
  88. ncbi The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation
    Sami I Said
    Pulmonary and Critical Care Medicine, SUNY Health Sciences Center, Stony Brook, NY 11794 8172, USA
    Ann N Y Acad Sci 1144:148-53. 2008
    ..Based on studies in a model of PAH resulting from targeted deletion of the neuropeptide vasoactive intestinal peptide (VIP) gene, we propose that, at least in this experimental model, but possibly also in other ..
  89. ncbi Involvement of endothelial NO in the dilator effect of VIP on rat isolated pulmonary artery
    - Anaid Shahbazian
    Institute of Cancer Research, University Clinic of Internal Medicine I, Medical University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
    Regul Pept 139:102-8. 2007
    ..b>Vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide, relaxes the rat pulmonary artery, but there is controversy as to ..
  90. ncbi VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFNgamma synthesis by T cells
    M Delgado
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102 1811, USA
    J Neuroimmunol 96:167-81. 1999
    ..This study examines the effect of two neuropeptides, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP), on interleukin-12 (IL-12) ..
  91. ncbi The neuropeptide vasoactive intestinal peptide generates tolerogenic dendritic cells
    Mario Delgado
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA
    J Immunol 175:7311-24. 2005
    ..In this report, we present evidence that two known immunosuppressive neuropeptides, the vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptide (PACAP), contribute to the ..
  92. pmc Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity
    Yong Jun Liu
    University of Missouri Kansas City, School of Medicine, Kansas City, Missouri, USA
    Obesity (Silver Spring) 18:2339-46. 2010
    ..Among all of the pathways analyzed, the vasoactive intestinal peptide (VIP) pathway was most strongly associated with fat mass (nominal P = 0...
  93. ncbi Therapeutical approaches of vasoactive intestinal peptide as a pleiotropic immunomodulator
    Elena Gonzalez-Rey
    Instituto de Parasitologia y Biomedicina Lopez Neyra CSIC, Granada, Spain
    Curr Pharm Des 13:1113-39. 2007
    The vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two neuropeptides belonging to the VIP/secretin/glucagon family of peptides...
  94. ncbi N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants
    F M Dautzenberg
    Pharma Division, Preclinical Research, F Hoffmann La Roche Ltd, Basel, Switzerland
    J Neuroendocrinol 11:941-9. 1999
    ..These data indicate that residues 53-88 within the N-terminal domain of the PAC1 are important for high affinity ligand binding, whereas residues 89-109 determine the receptor's ligand selectivity...
  95. ncbi Neuroprotection: a comparative view of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide
    Douglas E Brenneman
    Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, PA 19477, USA
    Peptides 28:1720-6. 2007
    The neuroprotective properties of vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) place these peptides in a special category of ligands that have implications for our understanding of ..
  96. ncbi Differential signal transduction by five splice variants of the PACAP receptor
    D Spengler
    CNRS UPR 9023, Mecanismes Moleculaires des Communications Cellulaires, CCIPE, Montpellier, France
    Nature 365:170-5. 1993
    ..Expression of these cDNAs revealed altered patterns of adenylyl cyclase and phospholipase C stimulation, suggesting a novel mechanism for fine tuning of signal transduction...
  97. ncbi Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways
    Bruno Cauli
    Laboratoire de Neurobiologie et Diversité Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7637, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, 75005 Paris, France
    J Neurosci 24:8940-9. 2004
    ..Identification of vasomotor interneurons by single-cell RT-mPCR revealed expression of vasoactive intestinal peptide (VIP) or nitric oxide synthase (NOS) in interneurons inducing dilatation and somatostatin (SOM) in ..
  98. ncbi Inhaled vasoactive intestinal peptide exerts immunoregulatory effects in sarcoidosis
    Antje Prasse
    Department of Pneumology, University Hospital, Freiburg, Germany
    Am J Respir Crit Care Med 182:540-8. 2010
    Previous studies suggest an important immunoregulatory role of vasoactive intestinal peptide (VIP) in experimental models of chronic noninfectious inflammation...
  99. ncbi Region-specific changes in the immunoreactivity of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC2, and PAC1 receptor) in the aged rat brains
    Jae Chul Lee
    Department of Anatomy, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Brain Res 1351:32-40. 2010
    Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) have been implicated in a large array of physiological and patho-physiological processes through their receptors (VPAC(1), VPAC(2), and PAC(1) ..
  100. pmc Tuning immune tolerance with vasoactive intestinal peptide: a new therapeutic approach for immune disorders
    David Pozo
    Departamento de Bioquimica Medica y Biologia Molecular, Universidad de Sevilla, Sevilla 41009, Spain
    Peptides 28:1833-46. 2007
    ..The vasoactive intestinal peptide (VIP) is a well-characterized endogenous anti-inflammatory neuropeptide with therapeutic potential for ..
  101. ncbi VIP differentially activates beta2 integrins, CR1, and matrix metalloproteinase-9 in human monocytes through cAMP/PKA, EPAC, and PI-3K signaling pathways via VIP receptor type 1 and FPRL1
    Nabil El Zein
    Hemato Oncology Unit and Laboratory of Pediatric Oncology, Hopital Universitaire des Enfants, Brussels, Belgium
    J Leukoc Biol 83:972-81. 2008
    The neuropeptide vasoactive intestinal peptide (VIP) regulates the exocytosis of secretory granules in a wide variety of cells of neuronal and non-neuronal origin...

Research Grants65

  1. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ....
  2. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..In this proposal we will determine the influence of these specific neuropeptides (vasoactive intestinal peptide (VIP), substance P (SP), and cholecystokinin (CCK)) on synaptic transmission in thalamocortical ..
  3. Neuropeptides and Regulatory T cells
    Doina Ganea; Fiscal Year: 2013
    ..We showed previously that dendritic cells (DC) differentiated in the presence of the neuropeptide vasoactive intestinal peptide (VIP) become tolerogenic, and induce regulatory T cells (Treg)...
  4. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
    ..In this proposal we will determine the influence of these neuropeptides (vasoactive intestinal peptide (VIP), substance P (SP), and cholecystokinin (CCK)) on synaptic transmission in thalamocortical ..
  5. Phospholipid Nanocarriers Improve Chemotherapy by Targeted Drug Delivery
    Hayat Onyuksel; Fiscal Year: 2010
    ..and exploits the attributes of sterically stabilized mixed micelles (SSMM) with surface-grafted vasoactive intestinal peptide (VIP)...
  6. Social and Motivational Properties of Vasoactive Intestinal Polypeptide Circuits
    James L Goodson; Fiscal Year: 2013
    ..Such processes are poorly understood, but are of clear relevance to mental health. ..
  7. Long-acting VIP formulations for the treatment of chronic inflammatory diseases
    Sandra Reichstetter; Fiscal Year: 2010
    ..b>Vasoactive intestinal peptide (VIP) is an immunomodulatory peptide that induces regulatory T-cells and anti-inflammatory cytokine ..
  8. Regeneration of periodontal structures through the recruitment of regulatory lymp
    ANDREW JASON GLOWACKI; Fiscal Year: 2013
    ..Our preliminary data shows treatment with vasoactive intestinal peptide (VIP) up-regulates the expression of endogenous Treg recruiting chemokine CCL-22 in gingival tissues ..
  9. Corneal endothelial cell survival in human donor corneas for transplantation
    Shay Whey M Koh; Fiscal Year: 2012
    ..Previously, We have reported how a CE autocrine trophic factor, the 28 amino-acid vasoactive intestinal peptide (VIP) maintains the differentiated state of the corneal endothelium, including CE cell size, shape, ..
  10. ALTERATION WITH AGE OF RESISTANCE TO EYE INFECTIONS
    Linda D Hazlett; Fiscal Year: 2013
    ..role of the pro- inflammatory neuropeptide, Substance P (SP) and the anti-inflammatory neuropeptide, vasoactive intestinal peptide (VIP) in regulation of inflammation, innate immunity and restoration of corneal homeostasis...
  11. Neuropeptide modulation of C. elegans light avoidance circuitry
    DEBTIRTHO DIPON GHOSH; Fiscal Year: 2013
    ..While PDF and its homolog Vasoactive Intestinal Peptide (VIP) mediate the circadian clock in insects and mammals, respectively, PDF function in worms is ..
  12. Mechanisms Underlying Activity-Dependent Interneuron Development
    NATALIA VANESA DE MARCO GARCIA; Fiscal Year: 2013
    ..indicates that the radial migration and morphological development of calretinin and reelin but not vasoactive intestinal peptide interneurons, the major subtypes derived from the caudal ganglionic eminence (CGE), are activity-..
  13. CELLULAR BASIS OF CIRCADIAN RHYTHMS IN MAMMALS
    ERIK HERZOG; Fiscal Year: 2013
    ..This project examines the role of specific neurons and signaling molecules in the circadian regulation of neural activity and gene expression in and between brain areas and in locomotor and sensory function. ..
  14. Community-Based, Phase III Trial of acupuncture to treat chronic Xerostomia
    Lorenzo Cohen; Fiscal Year: 2013
    ..Examine the role of expectancy for the benefits of acupuncture in predicting outcomes. The role of expectancy as a moderator of the effects of treatment will be thoroughly examined. ..
  15. HETEROCHROMATIN RECRUITMENT OF THE VPAC1 LOCUS BY IKAROS
    Glenn Paul Dorsam; Fiscal Year: 2010
    ..is to investigate the molecular mechanisms governing Ikaros-mediated transcriptional regulation of vasoactive intestinal peptide receptor - 1 (VPACR-1) in T lymphocytes...
  16. Eosinophil trafficking in fungal allergic asthma
    Glenn Paul Dorsam; Fiscal Year: 2013
    ..recruitment and trafficking of eosinophils in the lung lumen to signaling by a neuropeptide called vasoactive intestinal peptide (VIP)...
  17. Vasoactive intestinal peptide for the treatment of psoriasis
    Sandra Reichstetter; Fiscal Year: 2013
    ..We are proposing to formulate the immunomodulatory neuropeptide vasoactive intestinal peptide (VIP) into a long-acting formulation that will be tested as a drug candidate for the treatment of ..
  18. The role of VIP in the Circadian Regulation of Cardiovascular Rhythms
    ANALYNE M SCHROEDER; Fiscal Year: 2011
    ..The neuropeptide, Vasoactive Intestinal Peptide (VIP), is expressed in the SCN and is implicated in coordinating cellular oscillators...
  19. NEUROENDOCRINE CONTROL OF SMALL INTESTINAL MOTILITY
    Thomas Nowak; Fiscal Year: 1990
    ..Ultimately, this study will help to better understand the pathophysiology of motor abnormalities such as intestinal pseudoobstruction, paralytic ileus, and diabetic enteropathy...
  20. NEUROENDOCRINE ETIOLOGY OF DIABETIC GASTROPATHY
    Thomas Nowak; Fiscal Year: 1999
    ..Ultimately, the results of these investigations will improve not only the understanding of diabetic gastropathy, but also the treatment of patients with this disorder. ..
  21. VIP AND EGF RECEPTORS IN NON-SMALL CELL LUNG CANCER
    Terry Moody; Fiscal Year: 1991
    ..These studies will further define the cell surface receptors present on lung cancer cells and aid in determining if these receptors can be utilized to develop novel therapeutic approaches for the treatment of lung cancer...
  22. Intrinsic Anatomy of the Circadian Rhythm System
    LAWRENCE MORIN; Fiscal Year: 2005
    ..The results will provide the anatomical framework necessary for interpretation of future physiological and molecular experiments. ..
  23. 8th International Symposium for VIP, PACAP & Related Peptides
    Victor May; Fiscal Year: 2007
    ..Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are members of a superfamily composed of six genes encoding nine bioactive peptides...
  24. TACHYKININS & ARTERIAL CHEMORECEPTOR EXCITATION
    Nanduri Prabhakar; Fiscal Year: 1992
    ..This proposal may also yield information of potential use in the treatment of hypoxemia and hypercarbia which are major problems in chronic obstructive lung diseases...
  25. Functions of distinct interneuron subtypes in cortical dynamics and behavior
    Adam Kepecs; Fiscal Year: 2013
    ..to study three non-overlapping classes of interneurons: the parvalbumin (PV), somatostain (SOM), and vasoactive intestinal peptide (VIP) positive cells using knock-in Cre-driver lines, each with distinct functions...
  26. GONADAL AND PHENOTYPIC SEX DIFFERENTIATION
    FREDRICK GEORGE; Fiscal Year: 1993
    ..They plan to extend the observation that vasoactive intestinal peptide (VIP) stimulates steroidogenesis in the rat to other species, at least the rabbit, and then determine ..
  27. Volume Regulatory Pathways in Cystic Fibrosis Mice
    Won Kyoo Cho; Fiscal Year: 2003
    ..to isolate IBDU from normal mouse yielded intact polarized functional IBDU that responds to secretin, vasoactive intestinal peptide, and DBcAMP/IBMX. Similar IBDUs were also isolated from CF mice but need further characterization...
  28. NEUROTRANSMITTERS AND CYTOKINES IN TOOTH MOVEMENT
    ZEEV DAVIDOVITCH; Fiscal Year: 1992
    ..The specific aims are to: 1) localize the neuropeptides substance P, vasoactive intestinal peptide, methionine-enkephalin, calcitonin gene- related peptide and the cytokines Interleukin 1 alpha, 1 beta,..
  29. NEUROPEPTIDE RECEPTORS IN OCULAR AND PERIPHERAL TISSUES
    Steven Rosenzweig; Fiscal Year: 1992
    The long range objective of this proposal is to analyze the structure and function of the receptors for vasoactive intestinal peptide (VIP) and insulin in retinal and hepatic membranes...
  30. NEUROIMMUNOMODULATION IN HUMAN GUT MUCOSA
    Peter Anton; Fiscal Year: 1993
    ..to determine which subsets express surface receptors for the neuropeptides Substance P (SP) and/or Vasoactive Intestinal Peptide (VIP)...
  31. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 1999
    ..They are the neuropeptides alpha-melanocyte stimulating hormone (alpha- MSH), and vasoactive intestinal peptide (VIP), along with transforming growth factor-beta (TGF-beta)...
  32. IMMUNE EFFECTOR VASOACTIVE INTESTINAL PEPTIDE RECEPTORS
    M O DORISIO; Fiscal Year: 1991
    ..b>Vasoactive intestinal peptide (VIP) is a 28 amino acid neuromodulator found in high concentrations in both central and peripheral ..
  33. CHLORIDE CHANNELS IN A MODEL EPITHELIUM--GALLBLADDER
    ARTHUR FINN; Fiscal Year: 1991
    ..and since it can be changed to a secreting organ by stimuli (such as inflammation, prostaglandins, vasoactive intestinal peptide, cholera toxin) which also lead to a secretory response in the intestine...
  34. NEUROCHEMISTRY OF GESTATION-PRODUCED ANALGESIA
    Alan R Gintzler; Fiscal Year: 2010
    ..abstract_text> ..
  35. Mechanisms of Cutaneous Vasodilation in Humans
    CHRISTOPHER MINSON; Fiscal Year: 2005
    ..Of these potential vasodilator substances, a role for vasoactive intestinal peptide (VIP) and adenosine in active cutaneous vasodilation appears likely and are specifically targeted in ..
  36. HYPOTHALAMIC CONTROL OF PROLACTIN SECRETION
    JAMES VOOGT; Fiscal Year: 2001
    ..Another major player may be vasoactive intestinal peptide (VIP), recognized as a neuromodulator of PRL, secretion and dominant peptide in the suprachiasmatic ..
  37. VIP, VIP RECEPTORS AND THE INTESTINAL EPITHELIAL CELL
    Toan Nguyen; Fiscal Year: 1992
    The effects of vasoactive intestinal peptide (VIP) on intestinal secretion have been well characterized...
  38. FUNCTION OF AMACRINE CELLS IN MAMMALIAN RETINA
    Ralph Jensen; Fiscal Year: 1991
    ..The specific aims of this project are: (1) to understand the role the neurotransmitter vasoactive intestinal peptide (VIP) plays in the formation of the receptive fields of ganglion cells; (2) to study the functional ..
  39. CHARACTERIZATION OF THE VIP RECEPTOR IN THE LUNG
    Sudhir Paul; Fiscal Year: 1992
    The objectives are: (1) To solubilize functional receptors for vasoactive intestinal peptide (VIP) from the lung; (2) To raise monoclonal anti-receptor antibody; (3) To purify the receptor and analyze its structure; (4) To demonstrate ..
  40. REGULATION OF IMMUNITY TO HERPES SIMPLEX VIRUS
    John Sheridan; Fiscal Year: 1990
    ..Experimental studies have also demonstrated that neuropeptides (NP) such as vasoactive intestinal peptide (VIP), somatostatin (SOM), substance P (SP), gastrin-releasing peptide (GRP) can affect lymphocyte ..
  41. LANGERHANS CELLS AND NERVES: BIDIRECTIONAL SIGNALING
    Richard Granstein; Fiscal Year: 2009
    ..calcitonin gene-related peptide (CGRP), pituitary adenylate activating polypeptide (PACAP), and vasoactive intestinal peptide (VIP)] are all able to modulate cutaneous immune responses in vivo and in vitro...
  42. IN VITRO INTERACTIONS BETWEEN CIRCADIAN CLOCK AFFERENTS
    Rebecca Prosser; Fiscal Year: 1999
    ....
  43. MECHANISMS OF PEPSINOGEN SECRETION FROM CHIEF CELLS
    Jean Pierre Raufman; Fiscal Year: 1990
    ..These cells have been used to determine that changes in cAMP mediate the actions of secretin, vasoactive intestinal peptide, prostaglandins, and cholera toxin, whereas changes in cell calcium concentration play a role in ..
  44. PRENATAL POLYDRUG EXPOSURE & CARDIOVASCULAR DEVELOPMENT
    Lena Sun; Fiscal Year: 1999
    ..alters its modulation by cholinergic neurotransmitters and autonomic neuropeptides, neuropeptide Y and vasoactive intestinal peptide; (2) enhances the presynaptic sympathetic neural development and function and (3) modifies postnatal ..
  45. VIP AND NO IN AIRWAY INFLAMMATION AND ASTHMA
    SAMI SAID; Fiscal Year: 2000
    ..The proposal will test the following specific hypotheses regarding two transmitters, vasoactive intestinal peptide (VIP) and nitric oxide (NO): 1) As cotransmitters of non-adrenergic, non-cholinergic relaxation, VIP ..
  46. HIV GP120 EFFECTS ON NEUROTRANSMISSION
    RICHARD ZIEGLER; Fiscal Year: 1993
    ..1) the induction of the synthesis of the neuromodulatory second messenger molecule, cAMP, by vasoactive intestinal peptide, a neuropeptide found in nerve terminals within the cerebral cortex hippocampus, amygdaloid nucleus ..
  47. HORMONAL REGULATION OF NEURONAL ONTOGENY
    Robert Hamill; Fiscal Year: 1993
    ..Do hormones interact directly with the neuron? 2) Do hormones regulate neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in pelvic ganglia? These two peptides are integrally involved in reproductive and excretory ..
  48. VIP--A MEDIATOR OF NEUROIMMUNE INTERACTIONS
    Doina Ganea; Fiscal Year: 2000
    ..neuropeptides such as substance P stimulate immune functions, whereas other neuropeptides such as the vasoactive intestinal peptide (VIP) exert primarily an anti-inflammatory action...
  49. Multiscale Modeling & Analysis of Circadian Rhythm Generation & Synchronization
    Linda Petzold; Fiscal Year: 2009
    ..hypothesis is that the coupling of individual pacemaker neurons is mediated by the neurotransmitter vasoactive intestinal peptide (VIP) prevalent in the suprachiasmatic nucleus (SCN)...
  50. Phenotype analysis of tyrosine hydroxylase neurons in rat and human cortices
    STEPHEN ASMUS; Fiscal Year: 2009
    ..The developmental coexpression of TH with GABA, vasoactive intestinal peptide (VIP), and the cholinergic enzyme choline acetyltransferase (ChAT) will be assessed...
  51. REGULATION OF THE RAT VIP RECEPTOR GENE
    Lin Pei; Fiscal Year: 2000
    b>Vasoactive intestinal peptide (VIP) is a 28 amino acid polypeptide with a broad spectrum of biological functions. The effects of VIP are mediated by high affinity receptors...
  52. ELECTRICAL & BIOCHEMICAL STUDIES OF PROLACTIN SECRETION
    AILEEN RITCHIE; Fiscal Year: 1990
    ..The secretion of prolactin from these cells is enhanced by thyrotropin releasing hormone, vasoactive intestinal peptide and estrogen and inhibited by somatostatin and acetylcholine...
  53. NO AND VIP IN GASTRIC MOTILITY USING KNOCKOUT MICE
    Hiroshi Mashimo; Fiscal Year: 1999
    ..This proposal uses mice with gene-targeted disruption of nitric oxide synthases (NOS) and vasoactive intestinal peptide (VIP) to understand their inhibitory role in gut neurotransmission and motility...
  54. VISUAL CORTEX: CELLULAR BASIS FOR NORADRENERGIC ACTIONS
    Chiye Aoki; Fiscal Year: 1993
    ..BAR) or one of four other putative transmitters, acetylcholine (Ach), GABA, neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) will be examined...
  55. IMAGING COLORECTAL CANCER WITH TC 99M VIP
    Mathew Thakur; Fiscal Year: 1999
    ..propose to test the feasibility of developing a radiopharmaceutical based on Tc-99m-labeled vasoactive intestinal peptide for receptor-specific uptake on tumors with over-expression, as further described by their abstract: "..
  56. Modulation of Lung Inflammation and Cell Death by VIP
    SAMI SAID; Fiscal Year: 2006
    ..2) Excitotic mechanisms are a major pathogenic factor in cell death due to oxidant stress; and 3) Vasoactive intestinal peptide (VIP) and the related pituitary adenylate cyclase activating peptide (PACAP) can effectively reduce or ..
  57. ECTOPIC HORMONE SYNTHESIS IN PHEOCHROMOCYTOMA CELLS
    Richard Goodman; Fiscal Year: 1991
    ..Understanding the mechanisms by which classical second messengers and other trans-acting factors regulate VIP production may help explain why some neural crest-derived tumors produce VIP...
  58. GASTROINTESTINAL NERVE CIRCUITS IN COLONIC CONTROL
    JOHN FURNESS; Fiscal Year: 1993
    ..including dynorphin, enkephalin, galanin, neuromedin U, neuropeptide Y, somatostatin, substance P and vasoactive intestinal peptide, of the neuronal marker calbindin D28K and of the putative transmitters serotonin and gamma-..
  59. CYTOKINE REGULATION OF VIP GENE EXPRESSION
    Aviva Symes; Fiscal Year: 2002
    ..CNTF and LIF induce expression of the gene that encodes the neuropeptide, vasoactive intestinal peptide (VIP), through a 180bp cytokine response element (CyRE) in the VIP promoter...
  60. Olfactory Neurons--Model for PACAP Neurotrophic Function
    Gabriele Ronnett; Fiscal Year: 2005
    ..The vasoactive intestinal peptide (VIP/pituitary adenylyl cyclase activating polypeptide (PACAP) family of neuropeptides is implicated ..
  61. NEUROPEPTIDES AND CARCADIAN RHYTHMS DURING AGING
    Phyllis Wise; Fiscal Year: 2000
    ..b>Vasoactive intestinal peptide (VIP) and somatostatin (SRIF) may play key roles as communicators of differential afferent input, ..
  62. OLFACTORY NEURONS:MODEL FOR PACAP NEUROTROPHIC FUNCTIONS
    Gabriele Ronnett; Fiscal Year: 2001
    ..The vasoactive intestinal peptide (VIP/pituitary adenylyl cyclase activating polypeptide (PACAP) family of neuropeptides is implicated ..
  63. GABAA RECEPTOR FUNCTION AND SUBUNIT EXPRESSION
    HERMES YEH; Fiscal Year: 1999
    ..Within the context of an operating neuronal circuit, the net result would be an alteration in the gating or efficacy of synaptic transmission. ..
  64. Peptidergic regulation of photic signaling within the SCN
    ANDREW MARTIN VOSKO; Fiscal Year: 2010
    ..One such neuropeptide, vasoactive intestinal peptide (VIP), appears to modulate light responses in the master circadian pacemaker of mammals, the ..
  65. NEUROENDOCRINE AND NEUROCHEMICAL FUNCTION DURING AGING
    Phyllis Wise; Fiscal Year: 1999
    ..Attention will be focused on vasoactive intestinal peptide (VIP), its major afferent input, serotonin (5HT), and a major efferent target, GnRH...