gastrointestinal hormones

Summary

Summary: HORMONES secreted by the gastrointestinal mucosa that affect the timing or the quality of secretion of digestive enzymes, and regulate the motor activity of the digestive system organs.

Top Publications

  1. ncbi Gastrointestinal hormones and food intake
    April D Strader
    Genome Research Institute, University of Cincinnati Medical Center, 2170 E Galbraith Road, Cincinnati, OH 45237, USA
    Gastroenterology 128:175-91. 2005
  2. ncbi Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
    Michelle Y Cheng
    Department of Pharmacology, University of California, Irvine, California 92697, USA
    Nature 417:405-10. 2002
  3. ncbi Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle
    S Battersby
    Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 89:2463-9. 2004
  4. pmc Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
    Carel W le Roux
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, UK
    Ann Surg 243:108-14. 2006
  5. pmc Gastrointestinal hormones regulating appetite
    Owais Chaudhri
    Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
    Philos Trans R Soc Lond B Biol Sci 361:1187-209. 2006
  6. pmc Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor
    Jemma Evans
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    FASEB J 23:2165-75. 2009
  7. pmc Prokineticin 1 signaling and gene regulation in early human pregnancy
    Jemma Evans
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:2877-87. 2008
  8. ncbi PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption
    Rachel Reynaud
    Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille CRN2M, Centre National de la Recherche Scientifique, Unité mixte de recherche 7286, Aix Marseille University, France
    J Clin Endocrinol Metab 97:E1068-73. 2012
  9. pmc The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations
    Cecilia Martin
    Harvard Center for Reproductive Endocrine Sciences, Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, 02114, USA
    Endocr Rev 32:225-46. 2011
  10. pmc Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 105:2640-5. 2008

Detail Information

Publications233 found, 100 shown here

  1. ncbi Gastrointestinal hormones and food intake
    April D Strader
    Genome Research Institute, University of Cincinnati Medical Center, 2170 E Galbraith Road, Cincinnati, OH 45237, USA
    Gastroenterology 128:175-91. 2005
    ....
  2. ncbi Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
    Michelle Y Cheng
    Department of Pharmacology, University of California, Irvine, California 92697, USA
    Nature 417:405-10. 2002
    ..The high expression of PKR2 mRNA within the SCN and the positive feedback of PK2 on its own transcription through activation of PKR2 suggest that PK2 may also function locally within the SCN to synchronize output...
  3. ncbi Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle
    S Battersby
    Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 89:2463-9. 2004
    ..91 +/- 0.75-fold elevation in PK1 expression, compared with controls (P < 0.05). These data identify a paracrine role for the PKs and their receptors in endometrial vascular function...
  4. pmc Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
    Carel W le Roux
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, UK
    Ann Surg 243:108-14. 2006
    ..To study the effect of bariatric surgery on the entero-hypothalamic endocrine axis of humans and rodents...
  5. pmc Gastrointestinal hormones regulating appetite
    Owais Chaudhri
    Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
    Philos Trans R Soc Lond B Biol Sci 361:1187-209. 2006
    The role of gastrointestinal hormones in the regulation of appetite is reviewed. The gastrointestinal tract is the largest endocrine organ in the body...
  6. pmc Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor
    Jemma Evans
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    FASEB J 23:2165-75. 2009
    ..These data describe a novel signaling pathway mediating maternal-embryonic crosstalk, in which embryonic hCG via endometrial PROK1 may play a pivotal role in enhancing receptivity and maintaining early pregnancy...
  7. pmc Prokineticin 1 signaling and gene regulation in early human pregnancy
    Jemma Evans
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:2877-87. 2008
    ..These data demonstrate that PROK1 and PROKR1 expression is elevated in human decidua during early pregnancy and that PROK1-PROKR1 interaction regulates expression of a host of implantation-related genes...
  8. ncbi PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption
    Rachel Reynaud
    Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille CRN2M, Centre National de la Recherche Scientifique, Unité mixte de recherche 7286, Aix Marseille University, France
    J Clin Endocrinol Metab 97:E1068-73. 2012
    ..Pituitary stalk interruption represents a frequent feature of congenital hypopituitarism, but only rare cases have been assigned to a known genetic cause...
  9. pmc The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations
    Cecilia Martin
    Harvard Center for Reproductive Endocrine Sciences, Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, 02114, USA
    Endocr Rev 32:225-46. 2011
    ....
  10. pmc Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 105:2640-5. 2008
    ..In summary, our studies verify a role for Bv8 in the mobilization and recruitment of myeloid cells and in the induction of tumor angiogenesis in the early stages of neoplastic progression...
  11. pmc Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum
    Lindsay W Cole
    Reproductive Endocrine Unit of the Department of Medicine, Harvard Reproductive Endocrine Sciences Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:3551-9. 2008
    ..Mice deficient in prokineticin 2(PROK2) and prokineticin receptor2 (PROKR2) exhibit variable olfactory bulb dysgenesis and GnRH neuronal migration defects reminiscent of human GnRH deficiency...
  12. ncbi Appetite control
    Katie Wynne
    Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    J Endocrinol 184:291-318. 2005
    ..It also considers future therapeutic targets for the treatment of obesity...
  13. ncbi Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor
    Daniel Chi Hong Lin
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 277:19276-80. 2002
    ..mRNA expression analysis reveals that prokineticin receptors are expressed in gastrointestinal organs, endocrine glands, and other tissues...
  14. pmc Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2
    Catherine Dode
    Institut Cochin, INSERM U567, Universite Rene Descartes, Paris, France
    PLoS Genet 2:e175. 2006
    ..They also shed new light on the complex genetic transmission of Kallmann syndrome...
  15. pmc Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei
    Haydn M Prosser
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 104:648-53. 2007
    ....
  16. pmc The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells
    Jennifer LeCouter
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 100:2685-90. 2003
    ..The testis exhibits relatively high turnover of endothelial cells. Therefore, Bv8 and EG-VEGF, along with other factors such as VEGF-A, may maintain the integrity and also regulate proliferation of the blood vessels in the testis...
  17. ncbi Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humans
    Jose A L Calbet
    Copenhagen Muscle Research Center, Rigshospitalet, Copenhagen, Denmark
    Eur J Nutr 43:127-39. 2004
    ..The influence of protein fractionation on gastric emptying and rate of appearance of their constituent amino acids in peripheral blood remains unknown...
  18. pmc Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C
    Hila Romi
    The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev, Ben Gurion University, Beer Sheva 84105, Israel
    Am J Hum Genet 90:893-9. 2012
    ..Because GUCY2C heterozygous and homozygous mutant mice are resistant to E. coli STa enterotoxin-induced diarrhea, it is plausible that GUCY2C mutations in the desert-dwelling Bedouin kindred are of selective advantage...
  19. ncbi Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men
    Ixchel M Brennan
    University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
    Am J Physiol Gastrointest Liver Physiol 303:G129-40. 2012
    ..of meals with modest variations in 1) fat, protein, and carbohydrate content and 2) protein load on gastrointestinal hormones, appetite, and subsequent energy intake in lean and obese subjects...
  20. ncbi Genetic analysis in patients with Kallmann syndrome: coexistence of mutations in prokineticin receptor 2 and KAL1
    P Canto
    Unidad de Investigación Médica en Biología del Desarrollo, Centro Medico Nacional Siglo XXI, Coordinacion de Investigacion en Salud, Instituto Mexicano del Seguro Social, Mexico, DF, Mexico
    J Androl 30:41-5. 2009
    ..Our results strengthen the hypothesis of possible digenic inheritance in some patients with KS. Likewise, our data extend previous reports demonstrating that PROKR2 plays a role in the etiology of this syndrome...
  21. ncbi Gastrointestinal hormones, energy balance and bariatric surgery
    M Bueter
    Department of Surgery, University of Zurich, Zurich, Switzerland
    Int J Obes (Lond) 35:S35-9. 2011
    ..Here we review how gastrointestinal hormones potentially regulate energy balance, and summarize current available experimental and clinical data on ..
  22. ncbi Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass procedure: a review
    Lauren M Beckman
    Department of Food Science and Nutrition, University of Minnesota, 225 Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave, St Paul, MN 55108 6099, USA
    J Am Diet Assoc 110:571-84. 2010
    ..Although successful, the mechanisms for weight loss are not completely understood and it is thought that gastrointestinal hormones play a role...
  23. ncbi Hypothalamic regulation of food intake and clinical therapeutic applications
    Katherine Anne Simpson
    Department of Investigative Medicine, Imperial College, London United Kingdom
    Arq Bras Endocrinol Metabol 53:120-8. 2009
    ..In addition there are many projections to and from the brainstem, cortical areas and reward pathways, which modulate food intake...
  24. ncbi Comparable early changes in gastrointestinal hormones after sleeve gastrectomy and Roux-En-Y gastric bypass surgery for morbidly obese type 2 diabetic subjects
    Fabiola Romero
    Endocrinology and Diabetes Department, Obesity Unit, Hospital Clinic Universitari, Villarroel 170, 08036 Barcelona, Spain
    Surg Endosc 26:2231-9. 2012
    ..This study aimed to compare the early changes in gastrointestinal hormones involved in insulin and glucagon secretion in morbidly obese T2DM subjects undergoing SG or RYGBP.
  25. ncbi Molecular cloning and characterization of prokineticin receptors
    Takatoshi Soga
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Ibaraki 305 8585, Tsukuba, Japan
    Biochim Biophys Acta 1579:173-9. 2002
    ..The tissue distribution of PK-Rs reported in this paper suggests that the prokineticins play multifunctional roles in vivo...
  26. ncbi Can gut hormones control appetite and prevent obesity?
    Owais B Chaudhri
    Department of Metabolic Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Diabetes Care 31:S284-9. 2008
    ..One therapeutic target is the development of agents based on the gastrointestinal hormones that control appetite...
  27. pmc The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism
    Ana Paula Abreu
    Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular, LIM 42, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brasil
    Neuroendocrinology 91:283-90. 2010
    ....
  28. ncbi [Foods and nutrients modulates the release of anorexigenic gastrointestinal hormones]
    Gustavo D Pimentel
    Disciplina de Fisiologia da Nutrição, Universidade Federal de Sao Paulo, Brasil
    Acta Med Port 23:891-900. 2010
    ....
  29. pmc The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain
    Elisa Giannini
    Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, I 00185 Rome, Italy
    Proc Natl Acad Sci U S A 106:14646-51. 2009
    ..Inhibiting PK2 formation or antagonizing PKRs may represent another therapeutic approach for controlling inflammatory pain...
  30. ncbi The physiological role of GLP-1 in human: incretin, ileal brake or more?
    Jörg Schirra
    Department of Internal Medicine II, Marchioninistr 15, University of Munich, Munich D 81377, Germany
    Regul Pept 128:109-15. 2005
    ..As human studies indicate a central action of GLP-1 in reduction of food intake, it is uncertain if this is a consequence of induction of satiety or of transduction of visceral aversive stress signals...
  31. ncbi Structural determinants required for the bioactivities of prokineticins and identification of prokineticin receptor antagonists
    Clayton M Bullock
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Mol Pharmacol 65:582-8. 2004
    ....
  32. ncbi Gastrointestinal satiety signals
    Owais B Chaudhri
    Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Annu Rev Physiol 70:239-55. 2008
    ..Physiologically, such peptides are thought to act as satiety signals and meal terminators. Here, we review the current state of the field of the effects of gut hormone action on appetite control...
  33. pmc Efferent projections of prokineticin 2 expressing neurons in the mouse suprachiasmatic nucleus
    Chengkang Zhang
    Department of Pharmacology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e7151. 2009
    ..The efferent projections of PK2-expressing neurons supported the role of PK2 as an output molecule of the SCN...
  34. ncbi Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors
    Yasushi Masuda
    Pharmaceutical Research Division, Takeda Chemical Industries Ltd, Wadai 10, Tsukuba, Ibaraki 300 4293, Japan
    Biochem Biophys Res Commun 293:396-402. 2002
    ..The mRNAs of both EG-VEGF/PK-R1 and -R2 were expressed in BACE. The identification of the receptors for EG-VEGF/prokineticins may provide a novel molecular basis for the regulation of angiogenesis in endocrine glands...
  35. pmc Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries
    Napoleone Ferrara
    Department of Molecular Oncology, Genentech Incorporated, South San Francisco, California 94080, USA
    Am J Pathol 162:1881-93. 2003
    ....
  36. ncbi Role of gastrointestinal hormones in the proliferation of normal and neoplastic tissues
    Robert P Thomas
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Endocr Rev 24:571-99. 2003
    ..The effects of these peptides on normal and neoplastic GI tissues will be described. Also, future perspectives and potential therapeutic implications will be discussed...
  37. pmc Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Department of Medicine and Harvard Reproductive Endocrine Science Centers, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:17447-52. 2007
    ..Homozygous loss-of-function PROK2 mutations cause both KS and nIHH...
  38. ncbi The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy
    Daniela Pasquali
    Department of Clinical and Experimental Medicine and Surgery, Endocrine Unit, Second University of Napoli, Via Pansini 5, 80131 Napoli, Italy
    Endocrinology 147:4245-51. 2006
    ..Thus, the level of EG-VEGF/PK1 could be useful for prostate cancer outcome evaluation and as a target for prostate cancer treatment in the future...
  39. ncbi Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    Farbod Shojaei
    Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 450:825-31. 2007
    ..Thus, Bv8 modulates mobilization of CD11b+Gr1+ cells from the bone marrow during tumour development and also promotes angiogenesis locally...
  40. ncbi Gut-brain cross-talk in appetite regulation
    Jaimini Cegla
    Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
    Curr Opin Clin Nutr Metab Care 13:588-93. 2010
    ..To review the role of gut hormones involved in appetite regulation and their potential in the treatment of obesity...
  41. ncbi Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon
    K V Haderslev
    Dept of Gastroenterology, Copenhagen University Hospital, Rigshospitalet, Denmark
    Scand J Gastroenterol 37:392-8. 2002
    ..This article describes the effect of GLP-2 on spinal and hip bone mineral density (BMD) and biochemical markers of bone turnover in these patients...
  42. pmc Prokineticin 2 and circadian clock output
    Qun Yong Zhou
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    FEBS J 272:5703-9. 2005
    ..The depolarizing effect of PK2 on neurons that express PK2 receptor may represent a possible mechanism for the regulatory role of PK2 in circadian rhythms...
  43. ncbi The biology of incretin hormones
    Daniel J Drucker
    Department of Medicine, The Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Ontario M5G 2C4, Canada
    Cell Metab 3:153-65. 2006
    ..This article summarizes current concepts of incretin action and highlights the potential therapeutic utility of GLP-1 receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes...
  44. ncbi Digestive physiology of the pig symposium: secretion of gastrointestinal hormones and eating control
    R E Steinert
    University of Adelaide Discipline of Medicine and Centre of Clinical Research Excellence in Nutritional Physiology, Interventions and Outcomes, Adelaide, SA 5005, Australia
    J Anim Sci 91:1963-73. 2013
    ....
  45. ncbi Coordinate upregulation of guanylin and uroguanylin expression by hypertonicity in HT29-18-N2 cells
    Kris A Steinbrecher
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Hospital Research Foundation, Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio 45229, USA
    Am J Physiol Cell Physiol 283:C1729-37. 2002
    ..We conclude that guanylin and uroguanylin are released in response to hypertonic stress and that regulation of these genes may be mediated by PKC isoforms...
  46. ncbi Role of gastrointestinal hormones in neuroblastoma
    W Clay Gustafson
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas, 77555, USA
    World J Surg 29:281-6. 2005
    ..Our study results demonstrate a role of GRP as an autocrine/paracrine growth factor and elucidate involvement of specific intracellular signaling, the phosphatidylinositol 3-kinase pathway, in the growth regulation of neuroblastoma...
  47. pmc Gastrointestinal hormones stimulate growth of Foregut Neuroendocrine Tumors by transactivating the EGF receptor
    Alessia Di Florio
    Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1804, USA
    Biochim Biophys Acta 1833:573-82. 2013
    ..These results raise the possibility that disruption of this signaling cascade by either EGFR inhibition alone or combined with receptor antagonists may be a novel therapeutic approach for treatment of foregut NETs/PETs...
  48. pmc Therapy for obesity based on gastrointestinal hormones
    Jonatan I Bagger
    Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Denmark
    Rev Diabet Stud 8:339-47. 2011
    ..This review discusses the effects of the incretin-based therapies in obesity, and provides an overview of intestinal peptides with promising effects as potential new treatments for obesity...
  49. pmc Plasma hormones facilitated the hypermotility of the colon in a chronic stress rat model
    Chengbai Liang
    Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China
    PLoS ONE 7:e31774. 2012
    To study the relationship between brain-gut peptides, gastrointestinal hormones and altered motility in a rat model of repetitive water avoidance stress (WAS), which mimics the irritable bowel syndrome (IBS).
  50. ncbi Metabolic surgery-principles and current concepts
    M Gass
    Department of Visceral Surgery, St Claraspital Basel, CH 4058 Basel, Switzerland
    Langenbecks Arch Surg 396:949-72. 2011
    ..In the almost six decades of bariatric surgery, a variety of surgical approaches to treating morbid obesity have been developed...
  51. pmc Bv8, the amphibian homologue of the mammalian prokineticins, induces a proinflammatory phenotype of mouse macrophages
    Cataldo Martucci
    Department of Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Br J Pharmacol 147:225-34. 2006
    ..7.--In conclusion, Bv8 appears to be able to induce the macrophage to migrate and to acquire a proinflammatory phenotype...
  52. ncbi Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1
    Jingcai Chen
    Pharmaceutical Research and Development, Johnson and Johnson LLC, 3210 Merryfield Row, San Diego, CA 92121, USA
    Mol Pharmacol 67:2070-6. 2005
    ..PKRs have been reported to couple to G(q) and G(i) proteins. In this report, we show that PKs not only stimulate Ca(2+) mobilization but also induce cAMP accumulation in PKR-expressing cells...
  53. ncbi The gut as the largest endocrine organ in the body
    H Ahlman
    Department of Surgery, at the Lundberg Laboratory for Cancer Research, Goteborg University, Sweden
    Ann Oncol 12:S63-8. 2001
    ..g. the secretory diarrhea associated with midgut carcinoid tumours...
  54. ncbi Peptide YY: a gut hormone associated with anorexia during infectious diarrhea in children
    Amy L Beck
    From the Department of Pediatrics, University of California San Francisco, San Francisco, CA
    J Pediatr 153:677-82. 2008
    ....
  55. ncbi Effects of long- and short-chain fatty acids on the release of gastrointestinal hormones using an ex vivo porcine intestinal tissue model
    Trudy Voortman
    TNO, P O Box 360, 3700 AJ Zeist, The Netherlands
    J Agric Food Chem 60:9035-42. 2012
    ..In conclusion, this porcine tissue model shows to be of advantageous use in a tiered approach to study the potential of satiety-inducing compounds to be selected for studies in humans...
  56. ncbi Role of gastrointestinal hormones in postprandial reduction of bone resorption
    Dennis B Henriksen
    Nordic Bioscience, Herlev, Denmark
    J Bone Miner Res 18:2180-9. 2003
    ..Investigations led to a dose escalation study with glucagon like peptide-2 (GLP-2) in postmenopausal women. We found a dose-dependent effect of GLP-2 on the reduction of bone resorption...
  57. ncbi Bv8/PK2 and prokineticin receptors: a druggable pronociceptive system
    Lucia Negri
    Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza, University of Rome, P le A Moro 5, 00185 Rome, Italy
    Curr Opin Pharmacol 12:62-6. 2012
    ..Availability of a nonpeptide PKR antagonist, leading to blockade of the Bv8/PKR system, ameliorates pain arising from tissue injury and reduces the time required for recovery from injury...
  58. ncbi Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Neuromolecular Med 11:114-22. 2009
    ..However, because our samples were small, it will be important to replicate and confirm these findings in other independent studies using larger samples...
  59. ncbi Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing
    C Moss
    Imperial College London, Nutrition and Dietetic Research Group, Section of Investigative Medicine, London, UK
    J Hum Nutr Diet 25:3-15. 2012
    ..This review explores how age influences gastrointestinal appetite hormones in humans, as well as how this may contribute to the development of age-related malnutrition...
  60. ncbi Implications of gastrointestinal hormones in the pathogenesis of obesity in prepubertal children
    Cinzia Bascietto
    Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy
    J Pediatr Endocrinol Metab 25:255-60. 2012
    ..In particular, it has been suggested that ghrelin ("hunger" peptide), and obestatin and glucagon-like peptide-1 (GLP-1) ("satiety" peptides) could play important roles in the pathogenesis of obesity...
  61. ncbi Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling
    Kwan L Ng
    Department of Pharmacology, University of California Irvine UCI, Irvine, CA 92697, USA
    Science 308:1923-7. 2005
    ..These findings define an essential role for G protein-coupled PK2 signaling in postnatal and adult OB neurogenesis...
  62. ncbi Dietary galacto-oligosaccharides and calcium: effects on energy intake, fat-pad weight and satiety-related, gastrointestinal hormones in rats
    Joost Overduin
    Department of Health, NIZO Food Research, PO Box 20, 6710 BA Ede, The Netherlands
    Br J Nutr 109:1338-48. 2013
    ..These results indicate that dietary GOS stimulate a number of physiological mechanisms that can reduce energy intake, regardless of the calcium phosphate content of the diet...
  63. ncbi Gastric electrical activity and gastrointestinal hormones in dyspeptic patients
    G Riezzo
    Laboratory of Experimental Pathophysiology, Scientific Institute of Gastroenterology, Via F Valente, 4, I 70013 Castellana Grotte, Bari, Italy
    Digestion 63:20-9. 2001
    To explore the patterns of gastric electrical activity, gastric emptying and gastrointestinal hormones in dyspeptic patients and relate them to Helicobacter pylori status.
  64. ncbi Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass surgery
    Lauren M Beckman
    Department of Food Science and Nutrition, University of Minnesota, Minneapolis, Minnesota, USA
    JPEN J Parenter Enteral Nutr 35:169-80. 2011
    ..This study evaluated changes in GI hormones and leptin post-RYGB. The study also evaluated whether GI hormones differed after a short-term dose of protein or fat...
  65. ncbi Obesity and gastrointestinal hormones-dual effect of angiotensin II receptor blockade and a partial agonist of PPAR-γ
    Hironori Nakagami
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, Japan
    Curr Vasc Pharmacol 9:162-6. 2011
    ..These favorable characteristics of telmisartan might be due to its action as a partial agonist of PPAR-γ, beyond its blood pressure-lowering effect, through Ang II blockade, which may be called "metabosartan"...
  66. ncbi Evidence for a role of the gut hormone PYY in the regulation of intestinal fatty acid-binding protein transcripts in differentiated subpopulations of intestinal epithelial cell hybrids
    G Hallden
    Department of Nutritional Sciences, University of California, Berkeley, California 94720 3104, USA
    J Biol Chem 272:12591-600. 1997
    ..In addition, these studies suggest a mechanism whereby luminal agents can modulate expression of proteins in terminally differentiated cells in the gastrointestinal mucosa...
  67. ncbi Obestatin: an interesting but controversial gut hormone
    Antonio Lacquaniti
    Department of Internal Medicine, University of Messina, Messina, Italy
    Ann Nutr Metab 59:193-9. 2011
    ..Given the current controversy regarding the effects of obestatin and its cognate ligand, this article provides the latest review of the physiological and pathological characteristics of this hormone...
  68. ncbi Appetite, food intake, and plasma concentrations of cholecystokinin, ghrelin, and other gastrointestinal hormones in undernourished older women and well-nourished young and older women
    Kerstin Sturm
    Department of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
    J Clin Endocrinol Metab 88:3747-55. 2003
    ..These observations suggest that reduced basal hunger, rather than increased meal-induced satiety, contributes to the anorexia of aging and that changes in CCK and ghrelin are unlikely to be responsible...
  69. pmc Prokineticin 2 is an endangering mediator of cerebral ischemic injury
    Michelle Y Cheng
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:5475-80. 2012
    ..These findings indicate that PK2 can be activated by pathological stimuli such as hypoxia-ischemia and excitotoxic glutamate and identify PK2 as a deleterious mediator for cerebral ischemia...
  70. ncbi Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport
    Robert P Watson
    Novartis Institutes for BioMedical Research, Novartis Horsham Research Centre, Horsham, West Sussex, UK
    Neurogastroenterol Motil 24:65-75, e12. 2012
    ..Given the established role of prokineticin signaling on gastrointestinal function, we have explored Prok2 gene expression in inflammatory conditions of the gastrointestinal tract and assessed the possible consequences on gut physiology...
  71. ncbi Effects of orally disintegrating vs regular olanzapine tablets on body weight, eating behavior, glycemic and lipid indices, and gastrointestinal hormones: a randomized, open comparison in outpatients with bipolar depression
    William V Bobo
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Ann Clin Psychiatry 23:193-201. 2011
    ..This randomized, open-label trial aimed to compare the metabolic effects of olanzapine orally disintegrating tablets (ODT) and solid oral tablets (SOT) in bipolar depressed and mixed outpatients...
  72. pmc Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons
    Ping Ren
    Department of Pharmacology, Xianning College, Xianning, Hubei, People s Republic of China
    PLoS ONE 6:e20263. 2011
    ..And the inhibitory effect of PK2 required PKC activation in the postsynaptic cells. Our data suggest that PK2 could alter cellular activities within the SCN and may influence behavioral and physiological rhythms...
  73. ncbi Effect of ileal infusion of short-chain fatty acids on pancreatic prandial secretion and gastrointestinal hormones in pigs
    Vaida Sileikiene
    Institute of Animal Nutrition and daggerBioinformatics Unit, University of Hohenheim, Stuttgart, Germany
    Pancreas 37:196-202. 2008
    ..This study investigated the effect of ileal SCFAs on pancreatic secretion and plasma levels of peptide YY, cholecystokinin, motilin, and neurotensin...
  74. ncbi Prokineticin 2 modulates the excitability of subfornical organ neurons
    G Trevor Cottrell
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Neurosci 24:2375-9. 2004
    ..The activation of SFO neurons by PK2 illustrates a mechanism through which this peptide may exert circadian control of autonomic functions...
  75. pmc Impaired pain sensation in mice lacking prokineticin 2
    Wang Ping Hu
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Mol Pain 2:35. 2006
    ..Taken together, these results reveal that PK2 sensitize nociception without affecting inflammation...
  76. ncbi Prokineticin 1, homeobox A10, and progesterone receptor messenger ribonucleic acid expression in primary cultures of endometrial stromal cells isolated from endometrium of healthy women and from eutopic endometrium of women with endometriosis
    Federica Tiberi
    Istituto Scientifico Internazionale Paolo VI, Università Cattolica del Sacro Cuore UCSC, Rome, Italy
    Fertil Steril 94:2558-63. 2010
    ....
  77. ncbi Prokineticin 2 modulates the excitability of area postrema neurons in vitro in the rat
    Matthew V Ingves
    Department of Physiology, Queen s University, Kingston, ON, Canada K7L 3N6
    Am J Physiol Regul Integr Comp Physiol 298:R617-26. 2010
    ..These data suggest that the level of AP neuronal excitability may be regulated by PK2, ultimately affecting AP autonomic control...
  78. ncbi Prokineticin 2 suppresses GABA-activated current in rat primary sensory neurons
    Yan Cai Xiong
    Department of Pharmacology, Xianning College, 88 Xianning Road, Xianning 437100, Hubei, PR China
    Neuropharmacology 59:589-94. 2010
    ....
  79. pmc Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss
    Madhuri Salker
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom
    PLoS ONE 5:e10287. 2010
    ....
  80. pmc Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2
    Shun ichiro Matsumoto
    Molecular Medicine Research Laboratories, Drug Discovery Research, Astellas Pharma, Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Proc Natl Acad Sci U S A 103:4140-5. 2006
    ..Our current findings demonstrated that physiological activation of PKR2 is essential for normal development of the OB and sexual maturation...
  81. ncbi A gut feeling for obesity: 7TM sensors on enteroendocrine cells
    Maja S Engelstoft
    Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
    Cell Metab 8:447-9. 2008
    ..2008) and in this issue (Reimann et al., 2008)...
  82. ncbi Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells
    Farbod Shojaei
    Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Res 68:5501-4. 2008
    ..Thus, G-CSF may promote tumor angiogenesis through a Bv8-dependent pathway that bypasses VEGF and renders tumors refractory to anti-VEGF therapy...
  83. ncbi Identification of an angiogenic mitogen selective for endocrine gland endothelium
    J LeCouter
    Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Nature 412:877-84. 2001
    ..EG-VEGF is an example of a class of highly specific mitogens that act to regulate proliferation and differentiation of the vascular endothelium in a tissue-specific manner...
  84. pmc The AVIT protein family. Secreted cysteine-rich vertebrate proteins with diverse functions
    Alexandra Kaser
    Current address Institute of Genetics, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    EMBO Rep 4:469-73. 2003
    ..This shows that members of this new family of small proteins are involved in diverse biological processes...
  85. ncbi Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite
    W L Hall
    Centre for Nutrition and Food Safety, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH
    Br J Nutr 89:239-48. 2003
    ....
  86. ncbi Bv8/Prokineticins and their Receptors A New Pronociceptive System
    Lucia Negri
    Department of Physiology and Pharmacology, University Sapienza of Roma, P le Aldo Moro 5, 00185 Rome, Italy
    Int Rev Neurobiol 85:145-57. 2009
    ..Blockade of PKRs may represent a novel therapeutic strategy in acute and inflammatory pain conditions...
  87. pmc Evidence of prokineticin dysregulation in fallopian tube from women with ectopic pregnancy
    Julie L V Shaw
    Centre for Reproductive Biology, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Fertil Steril 94:1601-8.e1. 2010
    ..To demonstrate expression and regulation of prokineticins (PROKs) and their receptors (PROKRs) in fallopian tube (FT) from women who are not pregnant and women with ectopic pregnancy (EP)...
  88. ncbi Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy
    Pascale Hoffmann
    Institut National de la Santé et de la Recherche Médicale EMI 01 05, Département réponse et dynamique cellulaires Laboratoire d Angiogenèse, Commissariat a l Energie Atomique Grenoble, France
    Endocrinology 147:1675-84. 2006
    ..The expression pattern of EG-VEGF, its regulation by oxygen tension, and its complementary localization to that of VEGF suggest that this new factor might also be deregulated in preeclampsia...
  89. pmc Potential roles of the prokineticins in reproduction
    David Maldonado-Pérez
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Trends Endocrinol Metab 18:66-72. 2007
    ..Their expression has also been reported in various pathologies of the reproductive tract, and future studies will highlight whether inhibition of prokineticin function in these pathologies would be a useful therapeutic target...
  90. ncbi PYY and GLP-1 contribute to feedback inhibition from the canine ileum and colon
    J Wen
    Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol 269:G945-52. 1995
    ..This negative feedback loop also affects the distal small bowel. The proximal colon also triggers the feedback inhibition of gut motility (colonic brake)...
  91. pmc Prokineticin 2 depolarizes paraventricular nucleus magnocellular and parvocellular neurons
    Erik A Yuill
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Eur J Neurosci 25:425-34. 2007
    ..In combination, these studies have identified separate cellular mechanisms through which PK2 influences the excitability of different subpopulations of PVN neurons...
  92. ncbi Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome
    Ana Paula Abreu
    Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Disciplina de Endocrinologia e Metabologia, 05403 900 Sao Paulo, Brasil
    J Clin Endocrinol Metab 93:4113-8. 2008
    ..Physiological activation of the prokineticin pathway has a critical role in olfactory bulb morphogenesis and GnRH secretion in mice...
  93. pmc Altered circadian and homeostatic sleep regulation in prokineticin 2-deficient mice
    Wang Ping Hu
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Sleep 30:247-56. 2007
    ..In particular, mice lacking the PK2 gene (PK2-/-) have been shown to display significantly reduced rhythmicity for a variety of circadian physiological and behavioral parameters. We investigated the role of PK2 in sleep regulation...
  94. ncbi EG-VEGF and Bv8: a novel family of tissue-restricted angiogenic factors
    Napoleone Ferrara
    Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Biochim Biophys Acta 1654:69-78. 2004
    ..Bv8 expression is mainly restricted to the testis. The identification of these tissue-selective angiogenic factors raises the possibility that other secreted molecules with selectivity for the endothelium of other organs exist...
  95. ncbi Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor
    Stephen L Carrithers
    Department of Internal Medicine, Division of Infectious Diseases, Lexington VA Medical Center and University of Kentucky, Lexington, Kentucky 40506, USA
    Kidney Int 65:40-53. 2004
    ..However, the in vivo consequences of GN, UGN, and STa on renal function and their mechanism of action have yet to be rigorously tested...
  96. ncbi Cytokine properties of prokineticins
    Justin Monnier
    INSERM U620, Universite de Rennes 1, IFR 140, Rennes Cedex, France
    FEBS J 275:4014-21. 2008
    ..Their structure, size, signaling and biological activities are reminiscent of the chemokine superfamily. In this review, emphasis is placed on the properties of prokineticins as cytokines and their role in the immune system...
  97. ncbi Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis
    Chengkang Zhang
    Department of Pharmacology, University of California, Irvine, California 92697, USA
    J Biol Chem 282:6917-21. 2007
    ..Our results establish PK2 as a common functional target gene for different bHLH transcriptional factors in mediating their respective functions...
  98. ncbi Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8
    Vittorio Vellani
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom
    J Neurosci 26:5109-16. 2006
    ..The results suggest a role for prokineticins in physiological inflammation and hyperalgesia...
  99. ncbi Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior
    Lucia Negri
    Department of Human Physiology and Pharmacology Vittorio Erspamer, University of Roma La Sapienza, 00185 Roma, Italy
    J Neurosci 26:6716-27. 2006
    ..These findings indicate a modulatory role of PKR1 in acute nociception and inflammatory pain and disclose a pharmacological interaction between PKR1 and TRPV1 in nociceptor activation and sensitization...
  100. pmc Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization
    Jennifer LeCouter
    Department of Physiology, Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 101:16813-8. 2004
    ..Bv8 potentially modulates growth, survival, and function of cells of the innate and adaptive immune systems, possibly through autocrine or paracrine signaling mechanisms...
  101. ncbi The importance of acclimatisation and habituation to experimental conditions when investigating the anorectic effects of gastrointestinal hormones in the rat
    C R Abbott
    Endocrine Unit, Imperial College London, Hammersmith Campus, London, UK
    Int J Obes (Lond) 30:288-92. 2006
    ..We have investigated the effect of handling, exposure to a novel environment or to environmental enrichment on the anorectic effect of these gut hormones...

Research Grants62

  1. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..The mechanisms leading to the sensation of appetite and the release of gastrointestinal hormones in response to meal stimuli play an important role in the regulation of body weight homeostasis...
  2. Comparative Effectiveness of Medical Therapy vs. Bariatric Surgery for Obese T2DM
    DAVID BRADLEY contact LAUTZ; Fiscal Year: 2010
    ..b>Gastrointestinal hormones including incretins (GLP-1, GIP) and appetite regulating peptides (ghrelin, PYY, leptin) will be ..
  3. Motivational Changes for Nutritionally Relevant Tastes after Gastric Bypass
    Alan C Spector; Fiscal Year: 2013
    ..After RYGB, circulating levels of key anorexogenic gastrointestinal hormones such as peptide YY and glucagon-like peptide-1 increase...
  4. Understanding the role of bile as a mechanism for improved glucose homeostasis fo
    APRIL DAWN STRADER; Fiscal Year: 2010
    ..It is known that nutrient infusions into the gut will stimulate the secretion of gastrointestinal hormones like GLP-1 and PYY...
  5. STUDIES IN GASTROINTESTINAL ENDOCRINOLOGY
    Mark R Hellmich; Fiscal Year: 2010
    ..in the gastrointestinal (Gl) tract and to provide useful new information on these mechanisms by which gastrointestinal hormones (GIH) and growth factors influence gut function...
  6. NEURAL SUBSTRATES OF PEPTIDE INDUCED SATIETY
    Robert C Ritter; Fiscal Year: 2012
    ..provided by applicant): The overall goal of this work is to define the neural mechanisms through which gastrointestinal hormones, especially cholecystokinin (CCK) and glucagon-related peptide (CCK), control food intake and to ..
  7. Autocrine/Paracrine Regulation of Intrahepatic Bile Duct Growth
    GIANFRANCO D ALPINI; Fiscal Year: 2013
    ..regulating the functional heterogeneous responses of small and large intrahepatic cholangiocytes to gastrointestinal hormones and liver injury/toxins...
  8. Mechanisms Regulating Gastrointestinal Hormone Secretion
    Rodger A Liddle; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gastrointestinal hormones are produced by discrete neuroendocrine cells which are scattered throughout the intestine...
  9. CALCIUM AND PANCREATIC STIMULUS-SECRETION COUPLING
    John A Williams; Fiscal Year: 2013
    The overall aim of this research is to understand how regulatory neurotransmitters and gastrointestinal hormones act through changes in intracellular free Ca2+ to bring about digestive enzyme secretion by pancreatic acinar cells...
  10. Cincinnati Mouse Metabolic Phenotyping Center
    Patrick Tso; Fiscal Year: 2013
    ..Lipid, Lipoprotein, and Glucose Metabolism Core will study lipid and glucose metabolism and measure gastrointestinal hormones known to influence insulin secretion;4) Cardiovascular Core will provide numerous assessments of ..
  11. SURGICAL STUDIES ON METABOLISM OF G. I. HORMONES
    James Thompson; Fiscal Year: 1993
    The objectives of this proposal are to investigate the role of gastrointestinal hormones (GIH) in the digestive (and related) processes...
  12. INTESTINAL AND COLONIC CYTOCHROME P450 GENE EXPRESSION
    Peter Traber; Fiscal Year: 1993
    ..Finally, physiologic factors such as bile and gastrointestinal hormones, which may be responsible for maintaining expression of P450 genes in the small intestine and colon will ..
  13. MECHANISM OF DIETARY ADAPTATION OF PANCREATIC FUNCTION
    PATSY BRANNON; Fiscal Year: 1990
    ..The role of glucose, and its interaction with insulin and gastrointestinal hormones, in the regulation of both enzymes will be investigated...
  14. BIOSYNTHESIS OF GASTROINTESTINAL HORMONES
    Andrew Leiter; Fiscal Year: 1990
    ..In addition the gene encoding PYY will be isolated from a genomic library. Finally, the tissue localization of PYY and PP and the fetal development of PP will be defined utilizing the technique of in situ hybridization...
  15. Brainstem Esophageal-Gastric Reflexes
    Richard Rogers; Fiscal Year: 2009
    ..We have previously shown that extrinsic factors, especially gastrointestinal hormones, directly and dramatically modulate vago-vagal reflex control of the gut...
  16. SURGICAL STUDIES ON METABOLISM OF GI HORMONES
    Guillermo Gomez; Fiscal Year: 2003
    ..The Specific Aims of this research proposal are: 1) to determine the role of gastrointestinal hormones in the regulation of pancreatic apoptosis and regeneration in experimental models of acute pancreatitis; ..
  17. PANCREATIC PHYSIOLOGY STUDIES
    MORTON GROSSMAN; Fiscal Year: 1980
    ..Trophic Effects of Gastrointestinal Hormones. Pancreatic weight, DNA synthesis and content, and enzyme content will be measured after treatment with ..
  18. SEARCH FOR NOVEL GASTROINTESTINAL HORMONES
    Gary Gray; Fiscal Year: 1991
    ..We anticipate that such studies will shed further light on the regulatory mechanisms of the digestive system and will have implications toward understanding the pathogenesis of some digestive diseases...
  19. ALCOHOL & PANCREATIC DIGESTIVE ENZYME SYNTHESIS
    BIDDANDA PONNAPPA; Fiscal Year: 1991
    ..effects of ethanol ingestion on pancreatic protein synthesis and turnover is mediated by the release of gastrointestinal hormones such as cholecystokinin and secretin will be tested...
  20. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..Particular focus is on the hypothalamic melanocortin and dopaminergic pathways and gastrointestinal hormones involved in the regulation of food intake...
  21. CHARACTERIZATION OF HUMAN GASTROINTESTINAL HORMONES
    Terry Lee; Fiscal Year: 1991
    ..Walsh, Reeve, and Vigna at the Wadsworth VA in Los Angeles. Our collaborators will perform physiological and membrane receptor studies with the newly identified peptide hormones...
  22. 14th International Symposium on Regulatory Peptides
    Timothy Wang; Fiscal Year: 2002
    ..This symposium, which originated with a focus on gastrointestinal hormones, now includes coverage of other regulatory peptides and related molecules...
  23. REGULATION OF NEUROTENSIN-CONTAINING ENTERIC CELLS
    DIANE BARBER; Fiscal Year: 1991
    ..nutrient and transmitter regulation of a single peptide expressed in both endocrine and neural cells, thus increasing current understanding of the coordinated actions of gastrointestinal hormones and transmitters in digestive function.
  24. CELLULAR LOCALIZATION OF GASTRIN
    MARIE GREIDER; Fiscal Year: 1980
    ..and HCO3 minus, ), to amino acids (as histidine, phenylalanine, glycine and arginine), and to other gastrointestinal hormones is being studied...
  25. GROWTH FACTORS AND PANCREATIC CANCER
    ROBERT BEAUCHAMP; Fiscal Year: 1991
    ..I further plan to determine whether the gastrointestinal hormones which cause in vivo pancreatic growth in rodents can induce alterations of TGF production, TGF receptors ..
  26. Metabolic and Epigenetic Effects of Maternal High Fat Diet in Obesity Prone Rats
    Timothy H Moran; Fiscal Year: 2010
    ..The results of these experiments will enhance our understanding of the etiology of obesity and metabolic disease ultimately allowing the development of rational clinical interventions for such conditions. ..
  27. Low Carbohydrate Diets: Feeding and Endocrine Signaling
    Timothy Moran; Fiscal Year: 2006
    ..abstract_text> ..
  28. Society for the Study of Ingestive Behavior Annual Meet
    Timothy Moran; Fiscal Year: 2003
    ..abstract_text> ..
  29. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..abstract_text> ..
  30. GASTRIC NEUROPEPTIDASES/PEPTIDE RECEPTOR INTERACTIONS
    Catia Sternini; Fiscal Year: 2002
    ..We also plan to characterize GRP receptor recycling and resensitization in cells that normally express GRP receptors: gastric G cells, Swiss 3T3 cells, and small cell lung carcinoma line NCI-H345 cells. ..
  31. CONSTITUTIVELY ACTIVE DOPAMINE D1 AND D2 RECEPTORS
    Qun Yong Zhou; Fiscal Year: 2002
    ....
  32. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
    ..abstract_text> ..
  33. Chemosensing in the Gastrointestinal Tract
    Catia Sternini; Fiscal Year: 2010
    ....
  34. Modulation of Insulin Action by Testosterone in Men
    Nelly Pitteloud; Fiscal Year: 2010
    ..Therefore, if low T levels are shown to play a role in the pathogenesis of insulin resistance, T may well represent an important therapeutic modality for both preventing and treating the metabolic syndrome and type 2 diabetes in men. ..
  35. Prokineticin 2 and Suprachiasmatic Circadian Output
    Qun Yong Zhou; Fiscal Year: 2008
    ..the output of timing information from the SCN circadian crock, and could have a major impact on the future treatment of a number of circadian disorders such as jet-lag, shift work syndrome, and chronic insomnia [unreadable] [unreadable]..
  36. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2007
    ..abstract_text> ..
  37. ROLE OF GALANIN RECEPTORS IN GASTROINTESTINAL MOTILITY
    Catia Sternini; Fiscal Year: 2006
    ..abstract_text> ..
  38. Defintion of the Physiological Properties of GIP
    Michael Wolfe; Fiscal Year: 2007
    ..abstract_text> ..
  39. Role of Gastrin in the Pathogenesis of Colorectal Cancer
    Michael Wolfe; Fiscal Year: 2008
    ..The answers to these provocative hypotheses can only be achieved by gaining a thorough understanding of the molecular mechanisms by which gastrin exerts its trophic properties. ..
  40. HEDONICS AND DIETARY INTAKE OF FAT
    Richard Mattes; Fiscal Year: 2008
    ..This will be explored through stable isotope tracer studies for Aim 3. The proposed work will hold important public health, clinical, commercial and basic biological implications. [unreadable] [unreadable]..
  41. Gut to Brain Pathways for Infection-Induced Anxiety
    Mark Lyte; Fiscal Year: 2005
    ..abstract_text> ..
  42. Glucose-Sensing and Intestinal Feedback Inhibition
    Helen Raybould; Fiscal Year: 2007
    ..A greater understanding of these sensory mechanisms will help in understanding the pathophysiology of these diseases. ..
  43. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  44. Angiogenesis:Novel Basic Science Insight & Human Therapy
    Napoleone Ferrara; Fiscal Year: 2004
    ..abstract_text> ..
  45. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2004
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  46. NPY elicits meal-anticipatory responses
    DEBORAH DRAZEN; Fiscal Year: 2005
    ....
  47. SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEX
    Xueguo Zhang; Fiscal Year: 2002
    ....
  48. ROLE OF SENSING OF K+ INTAKE IN K+ HOMEOSTASIS
    JANG YOUN; Fiscal Year: 2005
    ..Significance: This project will potentially identify an important, previously unknown regulator of ECF K+ homeostasis. ..
  49. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  50. Mechanisms of ileal-induced weight loss
    APRIL STRADER; Fiscal Year: 2005
    ..Together these specific aims will help clarify the mechanisms underlying obesity surgery and may contribute to the development of more effective treatments for obesity. ..