Genomes and Genes
non steroidal estrogens
Summary: Non-steroidal compounds with estrogenic activity.
Publications227 found, 100 shown here
- Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor betaG G Kuiper
Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
Endocrinology 139:4252-63. 1998....
- Metabolism and kinetics of bisphenol a in humans at low doses following oral administrationWolfgang Völkel
Institut fur Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
Chem Res Toxicol 15:1281-7. 2002..The efficient glucuronidation of bisphenol A and the rapid excretion of the formed glucuronide result in a low body burden of the estrogenic bisphenol A in humans following oral absorption of low doses...
- Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley ratsR W Tyl
RTI, Research Triangle Park, North Carolina 27709 2194, USA
Toxicol Sci 68:121-46. 2002..001-5 mg/kg/day) on any parameters and no evidence of nonmonotonic dose-response curves across generations for either sex. BPA should not be considered a selective reproductive toxicant, based on the results of this study...
- Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part I: Bisphenol A and octylphenol as xeno-estrogensJ Oehlmann
Internationales Hochschulinstitut Zittau, Lehrstuhl Umweltverfahrenstechnik, Fachgruppe Human und Okotoxikologie, Markt 23, D 02763 Zittau, Germany
Ecotoxicology 9:383-97. 2000..cornuarietis is a promising candidate for a future organismic invertebrate model to identify endocrine-mimetic test compounds...
- Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: their structures and estrogenic potencyShin Ichi Yoshihara
Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
Toxicol Sci 78:50-9. 2004....
- Pubertal exposure to estrogenic chemicals affects behavior in juvenile and adult male ratsDaniele Della Seta
Department of Physiology, Section of Neuroscience and Applied Physiology, University of Siena, 53100 Siena, Italy
Horm Behav 50:301-7. 2006..This can be due to the much higher estrogenic potency of EE; the direction of the behavioral effects of BPA, compared with EE, is however indicative of an estrogenic mechanism...
- Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 miceDaniel Zalko
Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1089 Xénobiotiques, Toulouse, France
Environ Health Perspect 111:309-19. 2003..Thus, these data suggest the parental compound is responsible for the estrogenic effects observed in fetuses exposed to BPA during gestation in this mammalian model...
- Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levelsB S Rubin
Department of Anatomy and Cellular Biology, Tufts Medical School, Boston, MA 02111 USA
Environ Health Perspect 109:675-80. 2001..These data indicate an increased sensitivity to BPA during the perinatal period and suggest the need for careful evaluation of the current levels of exposure to this compound...
- Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavonesK D Setchell
Clinical Mass Spectrometry Center, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Am J Clin Nutr 68:1333S-1346S. 1998..These phytoestrogens and their metabolites have many potent hormonal and nonhormonal activities that may explain some of the biological effects of diets rich in phytoestrogens...
- Determination of free and total bisphenol A in human urine to assess daily uptake as a basis for a valid risk assessmentWolfgang Völkel
Bavarian Health and Food Safety Authority, Environmental Medicine Biomonitoring, Pfarrstrasse 3, Munchen, Germany
Toxicol Lett 179:155-62. 2008..5 microg/l was used and this value is 800-fold below the tolerable daily intake (TDI) of 50 microg/kg. Total BPA was determined in 147 urine samples with concentrations between <LOD and 9.3 microg/l...
- Bisphenol A-induced apoptosis of cultured rat Sertoli cellsHiroshi Iida
Laboratory of Zoology, Graduate School of Agriculture, Kyushu University, Higashiku Hakozaki 6 10 1, 812 8581 Fukuoka, Japan
Reprod Toxicol 17:457-64. 2003..Apoptosis-inducing cell death was observed in cells exposed to 150-200 microM BPA, while BPA at <100 microM had only slight cytotoxic effects on the cells...
- Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptorsTetsuya Adachi
Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
Food Chem Toxicol 43:713-9. 2005..In conclusion, we have demonstrated for the first time that long-term exposure to endocrine disrupters, such as BPA and NP, promotes in vitro insulin secretion from the pancreatic islets, via cytosolic/nuclear estrogen receptors...
- Metabolic activation of bisphenol A by rat liver S9 fractionS Yoshihara
Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
Toxicol Sci 62:221-7. 2001..The present results clearly indicate that BPA is metabolically activated in terms of estrogenicity under the conditions existing only with combined rat liver microsomes and cytosol...
- Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with Japanese medaka (Oryzias latipes)C D Metcalfe
Environmental and Resource Studies Program, Trent University, Peterborough, Ontario K9J 7B8, Canada
Environ Toxicol Chem 20:297-308. 2001....
- Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposureWade V Welshons
Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
Endocrinology 147:S56-69. 2006....
- Glucuronidation of the environmental oestrogen bisphenol A by an isoform of UDP-glucuronosyltransferase, UGT2B1, in the rat liverH Yokota
Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
Biochem J 340:405-9. 1999..These results indicate that bisphenol A, in male rat liver, is glucuronidated by UGT2B1, an isoform of UGT...
- Removal of estrogenic activity from municipal waste landfill leachate assessed with a bioassay based on reporter gene expressionAnja Coors
Department of Biology V Ecology, Ecotoxicology, Ecochemistry, Aachen University, Worringerweg 1, 52056 Aachen, Germany
Environ Sci Technol 37:3430-4. 2003....
- Exposure with the environmental estrogen bisphenol A disrupts the male reproductive tract in young miceT Takao
Second Department of Internal Medicine, Kochi Medical School, Nankoku, Japan
Life Sci 65:2351-7. 1999..These facts suggest that more detailed studies will warrant the assessment of the risk to the developing human testis from exposure to bisphenol A and other environmental estrogens in prepubertal and pubertal period...
- Gene expression changes in the immature rat uterus: effects of uterotrophic and sub-uterotrophic doses of bisphenol AJ Ashby
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK
Toxicol Sci 82:458-67. 2004..Therefore, in the present study, the no effect level for uterotrophic activity for BPA coincided with the no transcriptional effect level for uterine genes...
- Parent bisphenol A accumulation in the human maternal-fetal-placental unitGilbert Schönfelder
Institute of Clinical Pharmacology and Toxicology, Department of Toxicology, Benjamin Franklin Medical Center, Freie Universitat, Berlin, Berlin, Germany
Environ Health Perspect 110:A703-7. 2002..We suggest that the range of BPA concentrations we measured may be related to sex differences in metabolization of parent BPA or variable maternal use of consumer products leaching BPA...
- Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risksPhilippa D Darbre
School of Biological Sciences, The University of Reading, Reading RG6 6AJ, UK
J Appl Toxicol 28:561-78. 2008....
- Phyto-oestrogens through the life cycleA Cassidy
Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford, UK
Proc Nutr Soc 59:489-96. 2000....
- Selective oestrogen receptor modulators--current and future brain and behaviour applicationsU Halbreich
School of Medicine and Biomedical Sciences, SUNY Clinical Center, Room BB170, 462 Grider Street, Buffalo, NY 14215, USA
Expert Opin Pharmacother 1:1385-98. 2000..It is quite safe to predict that the recent accumulation of knowledge, combined with the large, thirsty anticipated market for these 'designer oestrogens', will lead to clinical trials of CNS-targeted SERMs in the very near future...
- Bisphenol-A and chlorinated derivatives in adipose tissue of womenM F Fernandez
Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18071 Granada, Spain
Reprod Toxicol 24:259-64. 2007..Because of the estrogen mimicking effects of BPA and its Cl(x)BPA, further research is needed to explore their combined effects on human health and trends in human exposure...
- Disposition of a low dose of bisphenol a in male and female cynomolgus monkeysHideo Kurebayashi
Division of Pharmacology, National Institute of Health Sciences, Kamiyoga 1 18 1, Setagaya, Tokyo 158 8501, Japan
Toxicol Sci 68:32-42. 2002..5%) after oral dose. These results indicate that the intestinal absorption and metabolism of BPA was rapid and extensive, and the major metabolites, glucuronide conjugates of 14C-BPA, were rapidly excreted into urine in monkeys...
- The toxic effects of 4-tert-octylphenol on the reproductive system of male ratsQian Bian
The Key Laboratory of Reproductive Medicine of Jiangsu Province, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China
Food Chem Toxicol 44:1355-61. 2006..These data demonstrate that OP affects testicular functions. The primary sites of action may be spermatogenic cells and Sertoli cells. The results of the present study provide first information of OP on sperm motility...
- Phenylphenols, biphenols, bisphenol-A and 4-tert-octylphenol exhibit alpha and beta estrogen activities and antiandrogen activity in reporter cell linesFrancoise Paris
INSERM Unite 439, Pathologie Moléculaire des Récepteurs Nucléaires, 70 rue de Navacelles, 34090 Montpellier, France
Mol Cell Endocrinol 193:43-9. 2002..In conclusion, these environmental chemicals may have a negative impact on androgen action during fetal and post-natal life...
- Neonatally administered tert-octylphenol affects onset of puberty and reproductive development in female ratsKristine N Willoughby
Endocrinology Program and Department of Animal Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901, USA
Endocrine 26:161-8. 2005..These data suggest that exposure to OP during the critical period of sexual brain differentiation affects the onset of puberty and reproductive development...
- Critical parameters in the MCF-7 cell proliferation bioassay (E-Screen)Thomas Høj Rasmussen
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, DK 5000 Odense C, Denmark
Biomarkers 7:322-36. 2002..The improved proliferation bioassay will be a useful tool in identifying potential xeno-oestrogens...
- Environmental estrogens can affect the function of mussel hemocytes through rapid modulation of kinase pathwaysLaura Canesi
Istituto di Scienze Fisiologiche, Universita di Urbino, Carlo Bo, Loc Crocicchia, 61029 Urbino, Italy
Gen Comp Endocrinol 138:58-69. 2004..Our data address to the importance of investigating full range responses to estrogenic chemicals and may help understanding their basic mechanisms of action in ecologically relevant invertebrate species...
- Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaningJ Odum
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, United Kingdom
Toxicol Sci 68:147-63. 2002..This study therefore does not establish a unique role for exposures in utero or during the early neonatal period...
- Effect of Bisphenol A on non-specific immunodefenses against non-pathogenic Escherichia coliYoshiko Sugita-Konishi
Division of Microbiology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
Toxicol Lett 136:217-27. 2003..The production of MCP-1 was enhanced by BPA treatment, but that of IL-6 was suppressed after infection. These results suggest that BPA possessed immunotoxicity and reduced the non-specific host defense as an acute toxicity...
- Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the "Enhanced OECD Test Guideline no. 407"Kanji Yamasaki
Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
Arch Toxicol 76:65-74. 2002....
- Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infantsAntonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 117:639-44. 2009..For 42 of these infants, we evaluated urinary concentrations of several phenols, including bisphenol A (BPA), in association with the use of the same medical devices...
- NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol ARobert E Chapin
Pfizer, Inc, Groton, CT, USA
Birth Defects Res B Dev Reprod Toxicol 83:157-395. 2008
- Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in ratsS C Laws
Endocrinology Branch, Reproductive Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 54:154-67. 2000..These data can be useful during the assessment and validation of methods for screening environmental chemicals for endocrine disrupting activity...
- Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytesHiroshi Masuno
Department of Medical Laboratory Technology, Ehime College of Health Science, Takooda, Tobe cho, Iyo gun, Ehime 791 2101, Japan
J Lipid Res 43:676-84. 2002..Taken together, our results indicate that BPA in combination with INS can accelerate the adipocyte conversion...
- Bisphenol A (BPA) daily intakes in the United States: estimates from the 2003-2004 NHANES urinary BPA dataJudy S LaKind
aLaKind Associates, LLC, Catonsville, Maryland, USA
J Expo Sci Environ Epidemiol 18:608-15. 2008..Median intake was approximately three orders of magnitude below health-based guidance values of 50 microg/kg-day...
- Developmental exposure to low-dose estrogenic endocrine disruptors alters sex differences in exploration and emotional responses in miceLaura Gioiosa
Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Viale Usberti 11A, 43100 Parma, Italy
Horm Behav 52:307-16. 2007....
- Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary glandLaura N Vandenberg
Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, Massachusetts 02111, USA
Endocrinology 148:116-27. 2007..These results suggest that alterations in mammary gland phenotypes observed at puberty and adulthood in perinatally exposed mice have their origins in fetal development...
- Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancyJ C Kim
Toxicology Research Center, Korea Research Institute of Chemical Technology, Yuseong, Daejeon, Republic of Korea
Life Sci 69:2611-25. 2001....
- Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposureTessa J Murray
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, United States
Reprod Toxicol 23:383-90. 2007..Thus, fetal bisphenol A exposure is sufficient to induce the development of preneoplastic and neoplastic lesions in the mammary gland in the absence of any additional treatment aimed at increasing tumor development...
- Cancer risk in women prenatally exposed to diethylstilbestrolRebecca Troisi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Int J Cancer 121:356-60. 2007..Given that the population is still young, continued follow-up is necessary to assess the overall carcinogenic impact of prenatal DES exposure...
- Estrogenic chemicals at puberty change ERalpha in the hypothalamus of male and female ratsIlaria Ceccarelli
Department of Physiology, Section of Neuroscience and Applied Physiology, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
Neurotoxicol Teratol 29:108-15. 2007..EE increased testosterone in males at PND 37 and estradiol in females at PND 90. These results indicate the ability of estrogenic chemicals to change the reproductive neural circuits during puberty in male and female rats...
- Bisphenol A is released from used polycarbonate animal cages into water at room temperatureKembra L Howdeshell
Division of Biological Sciences, University of Missouri, Columbia, Missouri, USA
Environ Health Perspect 111:1180-7. 2003..Our findings suggest that laboratory animals maintained in polycarbonate and polysulfone cages are exposed to BPA via leaching, with exposure reaching the highest levels in old cages...
- Reproductive effects of long-term exposure to Bisphenol A in the fathead minnow (Pimephales promelas)P Sohoni
Department of Biological Sciences, Brunel University, Uxbridge, UB8 3PH
Environ Sci Technol 35:2917-25. 2001..The results demonstrate that BPA acts as a weak estrogen to fish when administered via the water, with effects on breeding at and above 640 micrograms/L...
- Bisphenol a induces both transient and permanent histofunctional alterations of the hypothalamic-pituitary-gonadal axis in prenatally exposed male ratsJorge G Ramos
Laboratorio de Endocrinologia y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, Casilla de Correo 242, 3000 Santa Fe, Argentina
Endocrinology 144:3206-15. 2003..These results support the hypothesis that prenatal exposure to environmental doses of BPA induces both transient and permanent age-dependent alterations in the male reproductive axis at different levels...
- Problems for risk assessment of endocrine-active estrogenic compoundsStephen H Safe
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
Environ Health Perspect 110:925-9. 2002..These results suggest that other receptors, such as the aryl hydrocarbon receptor, that also bind structurally diverse ligands may exhibit unique responses in vivo that are not predicted by standard in vitro bioassays...
- Tissue- and time-dependent estrogen receptor activation in estrogen reporter miceJ G Lemmen
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
J Mol Endocrinol 32:689-701. 2004..These could include selective ER modulators and environmental estrogens. In combination with the IVIS imaging system, this in vivo model is a powerful tool for assessing the kinetics of gene activation by estrogenic compounds...
- Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tractCaroline M Markey
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111 1800, USA
Biol Reprod 72:1344-51. 2005..In addition, BPA-induced alterations that specifically affect hypothalamic-pituitary-gonadal axis function may further contribute to the anomalies observed at 3 mo of age, long after the cessation of BPA exposure...
- Bisphenol A causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivityMasami Ishido
Endocrine Disruptors and Dioxin Research Projects, National Institute for Environmental Studies, Tsukuba, Japan
J Neurosci Res 76:423-33. 2004..We conclude that bisphenol A affected central dopaminergic system activity, resulting in hyperactivity due most likely to a large reduction of tyrosine hydroxylase activity in the midbrain...
- Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspringYasuyoshi Nikaido
Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
Reprod Toxicol 18:803-11. 2004..High-dose GEN and RES and high- and low-dose BPA and DES exerted transient effects on the reproductive tract and mammary glands, whereas ZEA exerted prolonged effects...
- Physiologically based pharmacokinetics of bisphenol ABeom Soo Shin
College of Pharmacy, Sungkyunkwan University, Kyonggi Do, Korea
J Toxicol Environ Health A 67:1971-85. 2004..8 min) predicted for humans were comparable to those previously predicted by simple allometric scaling. This PBPK model may provide insights into the tissue distribution characteristics as a result of human exposure to bisphenol A...
- Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostateT E Stoker
Endocrinology Branch, Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Biol Reprod 61:1636-43. 1999..This study demonstrates that prepubertal exposures to compounds that increase PRL secretion, albeit through different mechanisms, can increase the incidence of lateral prostate inflammation in the adult...
- Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar ratsMilena Durando
Laboratorio de Endocrinologia y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, Santa Fe, Argentina
Environ Health Perspect 115:80-6. 2007..Prenatal exposure to BPA has produced long-lasting and profound effects on rodent hormone-dependent tissues that are manifested 1-6 months after the end of exposure...
- Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cellsDavid W Singleton
Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267 0521, USA
Environ Res 100:86-92. 2006..5-fold by BPA. These results reveal novel effects by BPA and E2, raising interesting possibilities regarding the role of endocrine disruptors in sexual development...
- Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in micePaola L Palanza
Department of Evolutionary and Functional Biology, Parma University, Parco Area delle Scienze 11A, 43100 Parma, Italy
Environ Health Perspect 110:415-22. 2002..The changes seen in maternal behavior may be the result of a direct effect of BPA on the neuroendocrine substrates underlying the initiation of maternal behavior...
- Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratioKira C Taylor
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Development NICHD, NIH, DHHS, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852, USA
Environ Res 103:99-105. 2007..The direction of the odds ratios in this preliminary study varied by PCB groupings, supporting the need to study specific PCB patterns when assessing environmental influences on the secondary sex ratio...
- Leached components from dental composites and their effects on fertility of female miceAhmad S Al-Hiyasat
Department of Restorative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan
Eur J Oral Sci 112:267-72. 2004..The results suggest that leached components from the dental composite used and commercially purchased BPA have adverse effects on the fertility and reproductive system of female mice...
- Altered sexually dimorphic nucleus of the preoptic area (SDN-POA) volume in adult Long-Evans rats by dietary soy phytoestrogensT D Lund
The Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
Brain Res 914:92-9. 2001..These data suggest that consumption of phytoestrogens via a soy diet, significantly: (1) decreases body and prostate weight, (2) delays puberty onset, and (3) alters SDN-POA volumes during adulthood...
- The environmental estrogenic compound bisphenol A exerts estrogenic effects on mouse hippocampal (HT-22) cells: neuroprotection against glutamate and amyloid beta protein toxicityE Gursoy
Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0551, USA
Neurochem Int 38:181-86. 2001....
- Time to pregnancy and secondary sex ratio in men exposed prenatally to diethylstilbestrolLauren A Wise
Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
Am J Epidemiol 166:765-74. 2007..92 (95% confidence interval: 0.80, 1.04) comparing the exposed with the unexposed. In conclusion, prenatal DES exposure was not associated with a significant decrease in either fecundability or secondary sex ratio...
- Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tractRetha R Newbold
Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
Reprod Toxicol 24:253-8. 2007..These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation...
- Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostateJ G Ramos
, Faculty of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina
Biol Reprod 65:1271-7. 2001..These findings are significant in light of the data on human prostate cancers where alterations in the stroma compartment may enhance the invasive and/or malignant potential of the nascent tumor...
- Toxic effects of the mycotoxin zearalenone and its derivatives on in vitro maturation of bovine oocytes and 17 beta-estradiol levels in mural granulosa cell culturesF Minervini
Institute of Toxins and Mycotoxins, CNR, Viale Einaudi 51, 70125 Bari, Italy
Toxicol In Vitro 15:489-95. 2001....
- Prenatal exposure to bisphenol A up-regulates immune responses, including T helper 1 and T helper 2 responses, in miceShin Yoshino
Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Japan
Immunology 112:489-95. 2004..Similar results were obtained from females whose mothers had consumed BPA during pregnancy. These results suggest that prenatal exposure to BPA may result in the up-regulation of immune responses, especially Th1 responses, in adulthood...
- Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivityHolger Greschik
Département de Biologie et Génomique Structurales, Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, B P 10142, 67404 Illkirch, France
J Biol Chem 279:33639-46. 2004....
- Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushingC Brede
Naeringsmiddeltilsynet for Midt Rogaland, Stavanger, Norway
Food Addit Contam 20:684-9. 2003..7 + -4 microg l(-1) (dishwashed 169 times), respectively. None of the bottles released bisphenol A at levels that exceed the recently established provisional tolerable daily intake (0.01 mg kg(-1) body weight/day) in the European Union...
- Developing a marker of exposure to xenoestrogen mixtures in human serumA M Soto
Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, Massachusetts, USA
Environ Health Perspect 105:647-54. 1997....
- The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cellsYelena B Wetherill
Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
Mol Cancer Ther 1:515-24. 2002..These data implicate BPA as an inappropriate mitogen for prostatic adenocarcinoma cells and provide the impetus to study the consequence of BPA exposure on prostate cancer...
- Predicting plasma concentrations of bisphenol A in children younger than 2 years of age after typical feeding schedules, using a physiologically based toxicokinetic modelAndrea N Edginton
School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada
Environ Health Perspect 117:645-52. 2009..Of particular interest is the exposure of young children to BPA via food stored in BPA-containing packaging...
- Bisphenol A levels in human urineAkiko Matsumoto
Department of Environmental Health, University of Occupational and Environmental Health, Kitakyusyu, Japan
Environ Health Perspect 111:101-4. 2003..We speculate that recent changes made in Japan regarding the interior coating of cans used to package these beverages may partly explain these findings...
- Factors influencing the migration of bisphenol A from cansJeong Hun Kang
Department of Veterinary Public Health, Faculty of Agriculture, Miyazaki University, Kibanadai Nishi, Gakuen, Miyazaki shi 889 2192, Japan
J Food Prot 66:1444-7. 2003..Moreover, the presence of 5 to 20% glucose in cans heated to 121 degrees C resulted in increased BPA migration relative to that for water controls...
- Bisphenol A increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized ratsT Funabashi
Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
J Neuroendocrinol 15:134-40. 2003..The present study suggests that BPA influences reproductive functions, including sexual behaviour even in adulthood, by altering the PR system in the hypothalamus...
- Aggressive behavior and serum testosterone concentration during the maturation process of male mice: the effects of fetal exposure to bisphenol AKeisuke Kawai
Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Environ Health Perspect 111:175-8. 2003..The mechanism activating this aggressive behavior was not elevated testosterone concentration...
- Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the ratK Kubo
Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University 60, 812-8582, Fukuoka, Japan
Neurosci Lett 304:73-6. 2001..Our results suggest that the current methods to determine the NOAEL of artificial industrial chemicals may not be sufficient to detect a disruption of the sexual differentiation in the brain...
- Altered profiles of spontaneous novelty seeking, impulsive behavior, and response to D-amphetamine in rats perinatally exposed to bisphenol AWalter Adriani
Section of Behavioral Pathophysiology, Laboratorio Fisiopatologia O S, Istituto Superiore di Sanita, Roma, Italy
Environ Health Perspect 111:395-401. 2003..This may be a cause for concern for public health, confirming that exposure to a weak environmental estrogen in the period of sexual differentiation of the brain can influence adult behavior...
- Effect of bisphenol A on murine immune function: modulation of interferon-gamma, IgG2a, and disease symptoms in NZB X NZW F1 miceCatherine Sawai
Department of Biology, Carleton College, Northfield, Minnesota 55057, USA
Environ Health Perspect 111:1883-7. 2003..05). The long-lasting effects of BPA on IFN-gamma and IgG2a production likely contributed to the increased symptom-free period of the NZB/NZW mice...
- Sensitivity of the immature rat uterotrophic assay to mixtures of estrogensHelen Tinwell
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom
Environ Health Perspect 112:575-82. 2004..Given these uncertainties, we conclude that it may be most expedient to select and bioassay whole environmental mixtures of potential concern...
- Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States)E E Hatch
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Cancer Causes Control 12:837-45. 2001..The purpose of the current study was to evaluate the long-term risk of developing high-grade squamous neoplasia of the genital tract among women exposed prenatally to DES...
- Male reproductive toxicity of four bisphenol antioxidants in mice and rats and their estrogenic effectOsamu Takahashi
Department of Toxicology Tokyo Metropolitan Research Laboratory of Public Health, 24 1, Hyakunincho 3 chome, 169 0073 Shinjuku ku, Tokyo, Japan
Arch Toxicol 80:225-41. 2006..These results suggest that BM and TM are weakly toxic, possibly through an estrogenic mechanism to male reproductive organs in mice as well as rats, while MM and ME may be the direct testicular toxins in rats but not mice...
- Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approachJustin G Teeguarden
Biological Monitoring and Modeling, Pacific Northwest National Laboratory, 902 Battelle Boulevard, P7 56, Richland, Washington 99352, USA
Toxicol Sci 85:823-38. 2005....
- In utero exposure to low doses of bisphenol A lead to long-term deleterious effects in the vaginaG Schönfelder
Department of Toxicology, Institute of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, FU Berlin, Garystrasse 5, 14195 Berlin, Germany
Neoplasia 4:98-102. 2002..ER alpha downregulation seems to be responsible for the observed altered vaginal morphology...
- An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessmentFrederick S vom Saal
Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
Environ Health Perspect 113:926-33. 2005....
- Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproductionShizuka Honma
Graduate School of Integrated Science, Yokohama City University, 22 2 Seto, Kanazawa ku 236 0027, Japan
Reprod Toxicol 16:117-22. 2002..The present results indicate that prenatal exposure to low doses of BPA and DES induces early vaginal opening, but does not affect reproductive functioning at the first breeding...
- Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male ratsFrancesca Farabollini
Institute of Human Physiology, University of Siena, Via Aldo Moro, Siena, Italy I 53100
Environ Health Perspect 110:409-14. 2002..On the contrary, we observed a potentiation of female behavior in females and a depotentiation of male behavior in males...
- Early cerebral activities of the environmental estrogen bisphenol A appear to act via the somatostatin receptor subtype sst(2)Rosa Maria Facciolo
Comparative Anatomy Laboratory, Ecology Department, University of Calabria, 87036 Rende, Cosenza, Italy
Environ Health Perspect 110:397-402. 2002....
- Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer reviewRonald Melnick
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 110:427-31. 2002....
- D-amphetamine-related reinforcing effects are reduced in mice exposed prenatally to estrogenic endocrine disruptorsGiovanni Laviola
Section of Behavioral Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena, 299 I 00161 Roma, Italy
Brain Res Bull 65:235-40. 2005..These data confirm that exposure to weak environmental estrogens in the period of brain sexual differentiation can influence adult behavior...
- The environmental estrogen bisphenol a inhibits estradiol-induced hippocampal synaptogenesisNeil J MacLusky
Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, New York, New York 10993 1195, USA
Environ Health Perspect 113:675-9. 2005..It may also exacerbate the impairment of hippocampal function observed during normal aging, as endogenous estrogen production declines...
- Reproductive outcomes in men with prenatal exposure to diethylstilbestrolKimberly M Perez
Department of Social and Preventive Medicine, University of Buffalo, State of New York, Buffalo, New York, USA
Fertil Steril 84:1649-56. 2005..To examine prenatal diethylstilbestrol (DES) exposure in relation to male reproductive outcomes...
- Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor statusYelena B Wetherill
Department of Cell Biology and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Cancer Res 65:54-65. 2005....
- Behavioral alterations in response to fear-provoking stimuli and tranylcypromine induced by perinatal exposure to bisphenol A and nonylphenol in male ratsTakayuki Negishi
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Environ Health Perspect 112:1159-64. 2004..g., electrical shock), as well as monoaminergic neural pathways. Key words: behavior, bisphenol A, fear, learning, monoamine, nonylphenol...
- Dietary soy phytoestrogen effects on brain structure and aromatase in Long-Evans ratsE D Lephart
Neuroscience Center, Brigham Young University, Provo, UT 84602, USA
Neuroreport 12:3451-5. 2001..e. anteroventral periventricular nucleus; AVPV) in male, but not in female rats. Since most commercial animal diets contain significant concentrations of phytoestrogens their influence on brain structure should be considered...
- Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and functionE D Lephart
Neuroscience Center, Brigham Young University, 633 WIDB, Provo, UT 84602, USA
Brain Res Brain Res Rev 37:25-37. 2001..a low phytoestrogen diet on visual spatial memory in male and female rats is presented...
- Disentangling the molecular mechanisms of action of endogenous and environmental estrogensAngel Nadal
Institute of Bioengineering, School of Medicine, Miguel Hernandez University, Sant Joan Campus, Carretera Alicante Valencia Km 87, 03550 Alicante, Spain
Pflugers Arch 449:335-43. 2005....
- Developmental effects of perinatal exposure to bisphenol-A and diethylstilbestrol on reproductive organs in female miceAtsuko Suzuki
Graduate School of Integrated Science, Yokohama City University, 22 2 Seto, Kanazawa ku 236 0027, Japan
Reprod Toxicol 16:107-16. 2002..3 or 3 microg) at 30 days. These findings indicate for the first time that a large dose of BPA can induce ovary-independent vaginal epithelial changes when given postnatally but not prenatally...
- Bisphenol A stimulates NO synthesis through a non-genomic estrogen receptor-mediated mechanism in mouse endothelial cellsSoichi Noguchi
Department of Obstetrics and Gynecology, Okayama University Medical School, 2 5 1 Shikata, Okayama 700 8558, Okayama City, Japan
Toxicol Lett 135:95-101. 2002..These results indicate that BPA stimulates NO synthesis through a non-genomic ER-mediated mechanism. Short-term effects of BPA on NO synthesis were weak but similar to 17beta-estradiol...
- The Chinese rare minnow (Gobiocypris rarus) as an in vivo model for endocrine disruption in freshwater teleosts: a full life-cycle test with diethylstilbestrolXueping Zhong
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
Aquat Toxicol 71:85-95. 2005..These findings indicate that exposure to DES causes a variety of developmental, reproductive and transgenerational effects...
- Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female ratsAnna Maria Aloisi
Institute of Human Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
Brain Res 937:1-7. 2002..These results indicate that exposure to BPA modified the activity of neural pathways and/or centers involved in nociception and pain in a sex-related and exposure-related manner...
- Expression of the estrogen-inducible EGFP gene in aromatase-null mice reveals differential tissue responses to estrogenic compoundsKatsumi Toda
Department of Molecular Genetics, School of Medicine, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
Mol Cell Endocrinol 229:119-26. 2005..In conclusion, the Ar(-/-) mouse carrying the E2-inducible EGFP gene is a valuable tool for quantitative analyses of natural and synthetic estrogenic compounds in vivo...
- ANALYSIS AND PHYSIOLOGY OF ISOFLAVONES IN SOYBEANSKenneth Setchell; Fiscal Year: 1993..We will also refine existing mass spectrometric methods to permit the determination of isoflavones in tissues. The results of these studies will permit the most appropriate design of future dietary intervention studies using soy protein...
- Phytoestrogens as an alternative treatment for MSLarry Sherman; Fiscal Year: 2006..unreadable] [unreadable]..
- PSYCHOBIOLOGY OF ESTROGEN RECEPTOR MODULATORSMark Wilson; Fiscal Year: 2003..These data will provide not only a better understanding of the biology of SERMs but will also help clinicians and patients evaluate of these compounds on behavioral health. ..
- COGNITIVE AGING: EFFECTS OF ESTRADIOL AND RALOXIFENEAGNES LACREUSE; Fiscal Year: 2000..abstract_text> ..
- Selective estrogen modulators and cognitionJames Herndon; Fiscal Year: 2005..These data in the rhesus monkey will provide valuable information on the efficacy of SERMs on female cognition and will help in evaluating the risks and benefits of using these compounds in hypoestrogenic women. ..
- Coactivation of Estrogen Receptor alpha/Sp1Stephen Safe; Fiscal Year: 2006..abstract_text> ..
- Colon Cancer Inhibition by a Class of PPARgamma AgonistsStephen Safe; Fiscal Year: 2009..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
- 2,3,7,8,--TCDD Effects on the Estrogenic ResponsesStephen Safe; Fiscal Year: 2006..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
- Mechanisms of Growth Factor-Estrogen Receptor CrosstalkStephen Safe; Fiscal Year: 2006..abstract_text> ..
- ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXESStephen Safe; Fiscal Year: 2002..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
- Inhibition of Pancreatic Cancer by New PPARgamma Agonis*Stephen Safe; Fiscal Year: 2008..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
- TOXICOLOGY OF ENVIRONMENT CONTAMINANTSStephen Safe; Fiscal Year: 2007..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
- ALKYL PCDFS--INHIBITION OF MAMMARY CANCERStephen Safe; Fiscal Year: 2001..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
- Plant Foods and Endometrial Cancer EpidemiologyPAMELA HORN ROSS; Fiscal Year: 2005..A priori definitions and factor analysis will be used to identify dietary patterns. The results of the proposed analyses will provide further understanding of the etiology of endometrial cancer. ..
- Nutrition and Thyroid Cancer Risk in the CTS CohortPAMELA HORN ROSS; Fiscal Year: 2007..The results of this research will have important implications for improving our understanding of the etiology of this disease which disproportionately affects young women. [unreadable] [unreadable] [unreadable]..
- Lifestyle Factors and Type 2 Diabetes in Black WomenJulie Palmer; Fiscal Year: 2008..Because the follow-up and data collection are funded by another grant, the proposed large study of modifiable risk factors for type 2 diabetes can be carried out at a relatively modest cost. ..
- Developmental toxicity of environmental chemicalsFREDERICK VOM SAAL; Fiscal Year: 2006..5a-reductase activity will be determined by radiometric assay. ..
- Serum IGFs--Effects of a Soy Intervention in HumansJohanna Lampe; Fiscal Year: 2002..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
- Human Gut Microflora Profiling for Population StudiesJohanna Lampe; Fiscal Year: 2006..abstract_text> ..
- Breast and Bone Density: Impact of Colonic EnvironmentJohanna Lampe; Fiscal Year: 2006..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
- Hormone Status Postmenopause: Colonic Bacterial EffectsJohanna Lampe; Fiscal Year: 2003..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
- Mammographic Density and Soy IsoflavonesLee Jane W Lu; Fiscal Year: 2010..The study may lead to a novel, non-invasive and economical approach to breast cancer prevention. ..
- Molecular Consequences of Estrogen-Induced InterferonyS Ahmed; Fiscal Year: 2007..1 Description, ..
- GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCESJohanna Lampe; Fiscal Year: 2006..abstract_text> ..
- HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCEJohanna Lampe; Fiscal Year: 2002..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
- Glucuronidation in Humans--Genotypes and PhenotypesJohanna Lampe; Fiscal Year: 2004..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
- The Association between obesity, central adiposity and endocrine disruptorsELIZABETH HATCH; Fiscal Year: 2007..Nevertheless, it may provide important clues for future, epidemiologic studies of the effect of these environmental contaminants on the risk of obesity. [unreadable] [unreadable] [unreadable]..
- UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal WomenJohanna Lampe; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Liquid Chromatography Mass Spectrometry systemAdrian Franke; Fiscal Year: 2005..abstract_text> ..
- UTERINE DISRUPTION: DNA METHYLATION & EPITHELIA-STROMAWILLIAM HENDRY; Fiscal Year: 2005..It should also yield important new insight into the topic of 'endocrine disruption'. ..
- Soy Isoflavone Distribution in Biological Fluids as Markers of Prostate ExposureMINDY KURZER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- DNA Damage: Fruit & Vegetable Effects in a Feeding TrialJohanna Lampe; Fiscal Year: 2005..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
- A Pilot Study Of Internet Recruitment and follow-up among Reproductive Age WomenELIZABETH HATCH; Fiscal Year: 2007..If successful, we envision this study to be the first of more elaborate studies that employ the internet to enroll cohort members into long-term follow-up studies. [unreadable] [unreadable] [unreadable]..
- Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese WomenJohanna Lampe; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Nongenomic Signaling Mechanisms of Environmental EstrogensCheryl S Watson; Fiscal Year: 2011..breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
- AGE-RELATED LOSS OF CYCLICITY--LHRH NEURONAL DYSFUNCTIONBEVERLY RUBIN; Fiscal Year: 2002..The studies proposed will determine if modulation of excitatory and inhibitory neurotransmission can enhance the normally diminished levels of LHRH neuronal activity in middle-aged females. ..
- Environmental Estrogens Acting via a Membrane ReceptorCHERYL WATSON; Fiscal Year: 2004..abstract_text> ..
- Does perinatal exposure to Bisphenol A contribute to adult obesityBEVERLY RUBIN; Fiscal Year: 2007..It is expected that these results, in turn, may generate a better understanding of the obesity problem, and provide elements to help devise a sound policy addressing this serious public health problem. ..
- TOTAL SYNTHESIS OF APOPTOLIDINK Nicolaou; Fiscal Year: 2004..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
- Negative Effects of Bisphenol A on the Monkey CNSCsaba Leranth; Fiscal Year: 2008..Therefore, we propose to reveal the effect of BPA on estrogen-induced spine synapse formation in the brain of non-human primates, which will provide more relevance to human health. [unreadable] [unreadable] [unreadable]..
- The Mouse Oocyte: A New Assay for Reproductive ToxinsPatricia Hunt; Fiscal Year: 2003..In addition, because the observed meiotic disruption (congression failure) is an age-related defect in human oocytes, the data may provide important insight to human age-related aneuploidy. ..
- TOTAL SYNTHESIS OF NATURAL PRODUCTSK Nicolaou; Fiscal Year: 2002..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
- Inflammatory Markers in a 2-Year Soy Intervention among Premenopausal WomenGertraud Maskarinec; Fiscal Year: 2008..The statistical analysis will apply general linear models to compare the levels of inflammatory markers by soy intake, while taking into account the repeated measurement design. [unreadable] [unreadable] [unreadable] [unreadable]..
- A prospective study of diet and endometriosisStacey Missmer; Fiscal Year: 2006..These analyses will be the first to evaluate the relation between these dietary factors and this important and understudied cause of morbidity among premenopausal women. [unreadable] [unreadable]..
- Endogenous Hormones and Risk of EndometriosisStacey Missmer; Fiscal Year: 2009..Establishment of follow-up among our younger cohort will provide resources for the first prospective study of endometriosis among adolescents. ..
- Effects of Soy on Estrogens in Breast Fluid and UrineGertraud Maskarinec; Fiscal Year: 2010..The NAF approach is the only way to learn more about the beneficial and adverse effects of soy directly in the female breast without applying invasive procedures to women without breast disease or surgery. ..
- Atherosclerosis Stage, Estrogen Receptors, and Vascular Responses to EstrogenTHOMAS COSTIN REGISTER; Fiscal Year: 2010....
- GENETIC CONTROL OF MEIOTIC CHROMOSOME SEGREGATIONPatricia Hunt; Fiscal Year: 2009..The combined data from these studies will allow us to understand the control of recombination In mammals and how the events of prophase influence meiotic chromosome segregation. ..
- NEUROENDOCRINE CONTROL OF FSHVasantha Padmanabhan; Fiscal Year: 2001....
- Role of estrogen receptor beta in cancer prevention by dietary indole-3-carbinolAbby Benninghoff; Fiscal Year: 2008..abstract_text> ..
- Prolactin and Estrogens as Mitogens in Prostate CancerNira Ben Jonathan; Fiscal Year: 2002..The findings on BPA may reveal the potential risk associated with human exposure to environmental estrogens. ..
- A Pilot Study of Acupuncture for Cancer-Related FatigueJudith Balk; Fiscal Year: 2006..This pilot study will enable a larger, more rigorous, well-controlled research study on the efficacy of acupuncture for cancer-related fatigue. ..
- Prenatal xenoestrogen exposure and mammary cancerANA SOTO; Fiscal Year: 2006..It may even influence public policy about prevention. ..
- Subcortical Estrogen Effect on The HippocampusCsaba Leranth; Fiscal Year: 2005..cholinergic and GABAergic septo-hippocampal neurons involved in mediating estrogenic effect to the hippocampus? and (d) Do SUM neurons mediate estrogenic effect to the hippocampus directly or indirectly, via the MSDB? ..
- Ovary Intact Murine Model for MenopausePatricia Hoyer; Fiscal Year: 2007..Characterization of the VCD-treated mouse will, therefore, make a profound contribution to the study of menopause-related pathologies and, therefore, to women's health. ..
- Effect of GnRH antagonist on primordial follicle survival in the primate ovaryDOUGLAS DANFORTH; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MECHANISMS OF CARDIOVASCULAR DISEASE AND GENE THERAPYLeslie Leinwand; Fiscal Year: 2005..In addition, we have established a formal link with the MD-PhD) program in Denver that allows those students to do their thesis work in Boulder. This training grant can facilitate those ventures. ..
- PROSTATE CELL PROLIFERATION IN CANCER AND AGINGANA SOTO; Fiscal Year: 2005..We expect that this research will lead to the development of markers to identify this phenotype, and to the development of specific therapeutic strategies. ..
- Variations in plasma phytoestrogen levels in EuropePetra Peeters; Fiscal Year: 2004..This pilot study will determine whether the variation of phytoestrogen concentrations in the European EPIC population is sufficient to justify further large-scale prospective nested case-control studies. ..
- Reproductive Consequences of Prenatal AndrogenizationVasantha Padmanabhan; Fiscal Year: 2005..Specifically it will establish that discrete, experimentally induced androgen excess of fetal sheep provides the first clear etiology for hyperandrogenic anovulation in adulthood. ..
- NEONATAL EFFECTS AND METABOLISM OF XENOESTROGENSNira Ben Jonathan; Fiscal Year: 2003..The results should provide a much needed experimental foundation for assessing the vulnerability of the neuroendocrine system to insults by environmental factors. ..
- Novel Approaches to Studying the Situ Bioremediation of Complex MixturesROLF HALDEN; Fiscal Year: 2009..abstract_text> ..
- Perinatal xenoestrogen exposure: epigenesis and neoplasiaANA SOTO; Fiscal Year: 2007..This will also have a great impact on the way we study risk factors and conduct epidemiological studies; it may even influence public policy about breast cancer prevention. [unreadable] [unreadable] [unreadable] [unreadable]..
- Advanced Reproductive Age and Environmental HealthStephanie Engel; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Identifying Gene Interactions in SLE by Mixed ChimerasEric Sobel; Fiscal Year: 2006..unreadable] Successful completion of these experiments would identify a novel method of systematically identifying epistatic interactions in an important murine model of SLE. [unreadable] [unreadable]..