Summary: Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.

Top Publications

  1. ncbi The complex role of estrogens in inflammation
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Endocr Rev 28:521-74. 2007
  2. ncbi Estrogen carcinogenesis in breast cancer
    James D Yager
    Bloomberg School of Public Health, Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 354:270-82. 2006
  3. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
  4. ncbi Mechanisms of estrogen action
    S Nilsson
    KaroBio AB and Department of Biosciences, Karolinska Institute, Novum, Huddinge, Sweden
    Physiol Rev 81:1535-65. 2001
  5. ncbi A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    Chetana M Revankar
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Science 307:1625-30. 2005
  6. pmc The role of estrogens in control of energy balance and glucose homeostasis
    Franck Mauvais-Jarvis
    Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Endocr Rev 34:309-38. 2013
  7. ncbi Estrogen receptors: how do they signal and what are their targets
    Nina Heldring
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Physiol Rev 87:905-31. 2007
  8. pmc The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants
    A M Soto
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, MA 02111, USA
    Environ Health Perspect 103:113-22. 1995
  9. ncbi Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
    P Thomas
    University of Texas Marine Science Institute, 750 Channel View Drive, Port Aransas, Texas 78373, USA
    Endocrinology 146:624-32. 2005
  10. doi Estrogen receptors and the metabolic network
    Rodrigo P A Barros
    Center for Nuclear Receptors and Cell Signaling, Department of Cell Biology and Biochemistry, University of Houston, Houston, TX 77004, USA
    Cell Metab 14:289-99. 2011

Detail Information

Publications360 found, 100 shown here

  1. ncbi The complex role of estrogens in inflammation
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Endocr Rev 28:521-74. 2007
    There is still an unresolved paradox with respect to the immunomodulating role of estrogens. On one side, we recognize inhibition of bone resorption and suppression of inflammation in several animal models of chronic inflammatory ..
  2. ncbi Estrogen carcinogenesis in breast cancer
    James D Yager
    Bloomberg School of Public Health, Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 354:270-82. 2006
  3. pmc Pathogenesis of osteoporosis: concepts, conflicts, and prospects
    Lawrence G Raisz
    University of Connecticut Health Center, Musculoskeletal Institute, Farmington, Connecticut 06032, USA
    J Clin Invest 115:3318-25. 2005
    ..However, new and more effective approaches are likely to emerge from a better understanding of the regulators of bone cell function...
  4. ncbi Mechanisms of estrogen action
    S Nilsson
    KaroBio AB and Department of Biosciences, Karolinska Institute, Novum, Huddinge, Sweden
    Physiol Rev 81:1535-65. 2001
    Our appreciation of the physiological functions of estrogens and the mechanisms through which estrogens bring about these functions has changed during the past decade...
  5. ncbi A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    Chetana M Revankar
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Science 307:1625-30. 2005
    ..Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology...
  6. pmc The role of estrogens in control of energy balance and glucose homeostasis
    Franck Mauvais-Jarvis
    Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Endocr Rev 34:309-38. 2013
    b>Estrogens play a fundamental role in the physiology of the reproductive, cardiovascular, skeletal, and central nervous systems...
  7. ncbi Estrogen receptors: how do they signal and what are their targets
    Nina Heldring
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Physiol Rev 87:905-31. 2007
    ..In this review we focus on several of the interesting recent discoveries concerning estrogen receptors, on estrogen as a morphogen, and on the molecular mechanisms of anti-estrogen signaling...
  8. pmc The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants
    A M Soto
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, Boston, MA 02111, USA
    Environ Health Perspect 103:113-22. 1995
    b>Estrogens are defined by their ability to induce the proliferation of cells of the female genital tract...
  9. ncbi Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
    P Thomas
    University of Texas Marine Science Institute, 750 Channel View Drive, Port Aransas, Texas 78373, USA
    Endocrinology 146:624-32. 2005
    ..7 nm), limited capacity, displaceable, single binding site specific for estrogens was detected in plasma membranes of SKBR3 breast cancer cells that express GPR30 but lack nuclear estrogen ..
  10. doi Estrogen receptors and the metabolic network
    Rodrigo P A Barros
    Center for Nuclear Receptors and Cell Signaling, Department of Cell Biology and Biochemistry, University of Houston, Houston, TX 77004, USA
    Cell Metab 14:289-99. 2011
    ..Imbalance of ERα/ERβ ratio in this "metabolic network" may lead to the metabolic syndrome...
  11. ncbi Sources of estrogen and their importance
    E R Simpson
    Monash Medical Center, Prince Henry s Institute of Medical Research, PO Box 5152, Clayton 3168, Vic, Australia
    J Steroid Biochem Mol Biol 86:225-30. 2003
    ..Thus, circulating levels of estrogens in postmenopausal women and in men are not the drivers of estrogen action, they are reactive rather than ..
  12. ncbi Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    R A Campbell
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:9817-24. 2001
    ..Anti-estrogens such as tamoxifen inhibit the growth of ER-positive breast cancers by reducing the expression of estrogen-..
  13. doi Progesterone induces adult mammary stem cell expansion
    Purna A Joshi
    Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada
    Nature 465:803-7. 2010
    ..Our findings uncover a dynamic role for progesterone in activating adult MaSCs within the mammary stem cell niche during the reproductive cycle, where MaSCs are putative targets for cell transformation events leading to breast cancer...
  14. doi Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma
    Hiromichi Niikawa
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 14:4417-26. 2008
    ..Therefore, we examined intratumoral estradiol concentrations in NSCLC to examine local actions of estrogens in NSCLC.
  15. ncbi Sex determination: insights from the chicken
    Craig A Smith
    Murdoch Childrens Research Institute and Department of Paediatrics, Royal Childrens Hospital, Parkville, Victoria, Australia
    Bioessays 26:120-32. 2004
    ..The chicken embryo resembles lower vertebrates in that estrogens play a central role in gonadal sex differentiation...
  16. doi Estrogen signaling through the transmembrane G protein-coupled receptor GPR30
    Eric R Prossnitz
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Annu Rev Physiol 70:165-90. 2008
    ..In this review, we provide an overview of the evidence for the cellular and physiological actions of GPR30 in estrogen-dependent processes and discuss the relationship of GPR30 with classical estrogen receptors...
  17. ncbi The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
    Justin Lamb
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Science 313:1929-35. 2006
    ..These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project...
  18. ncbi Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats
    Sachika Adachi
    Graduate School of Science and Engineering, Saitama University, Saitama, Japan
    J Reprod Dev 53:367-78. 2007
    ..Taken together, the present study demonstrates that the AVPV metastin/kisspeptin neurons are a target of estrogen positive feedback to induce GnRH/LH surges in female rats...
  19. ncbi Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    A Morishima
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Endocrinol Metab 80:3689-98. 1995
    The aromatase enzyme complex catalyzes the conversion of androgens to estrogens in a wide variety of tissues, including the ovary, testis, placenta, brain, and adipose tissue...
  20. ncbi Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption
    Peter Thomas
    Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373, USA
    J Steroid Biochem Mol Biol 102:175-9. 2006
    ..We show here that several of these environmental estrogens also bind to the novel seven-transmembrane estrogen receptor, GPR30, to activate alternative estrogen signaling ..
  21. ncbi Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models
    K P Bhat
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 61:7456-63. 2001
    ..In rodent models, carcinogen-induced preneoplastic lesions and mammary tumors are inhibited. These data suggest that resveratrol may have beneficial effects if used as a chemopreventive agent for breast cancer...
  22. pmc Estrogen deficiency and bone loss: an inflammatory tale
    M Neale Weitzmann
    Division of Endocrinology, Metabolism, and Lipids and Molecular Pathogenesis Program, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 116:1186-94. 2006
    ..Due to the inherent difficulties associated with human investigation, many of the lessons learned have been in animal models. Consequently, many of these principles await further validation in humans...
  23. pmc Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    D B Lubahn
    Department of Pathology, University of North Carolina, Chapel Hill 27599
    Proc Natl Acad Sci U S A 90:11162-6. 1993
    ..Prenatal male and female reproductive tract development can therefore occur in the absence of estradiol receptor-mediated responsiveness...
  24. pmc Minireview: Obesity and breast cancer: the estrogen connection
    Margot P Cleary
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Endocrinology 150:2537-42. 2009
    ..Human and relevant preclinical studies are cited. In addition, other growth factors that may be involved in this relationship are considered...
  25. doi Widespread estrogen-dependent repression of micrornas involved in breast tumor cell growth
    Gérard Maillot
    Institut National de la Sante et de la Recherche Medicale U563, Institut Claudius Regaud, and universite de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Cancer Res 69:8332-40. 2009
  26. pmc Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation
    Quan Guang Zhang
    Developmental Neurobiology Program, Institute of Molecular Medicine and Genetics, and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    J Neurosci 29:13823-36. 2009
  27. ncbi Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen
    S Khosla
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 83:2266-74. 1998
    ..These studies suggest that in contrast to traditional belief, age-related bone loss may be the result of E deficiency not just in postmenopausal women, but also in men...
  28. pmc Analysis of estrogens in serum and plasma from postmenopausal women: past present, and future
    Ian A Blair
    Centers of Excellence in Environmental Toxicology and Cancer Pharmacology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
    Steroids 75:297-306. 2010
    ..Postmenopausal women with elevated plasma or serum estrogens are at increased risk for breast cancer...
  29. pmc The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis
    Jingyung Hur
    Department of Tumor Biology, Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:2351-6. 2004
    ..induced by estrogen starvation or exposure to fulvestrant, a pure antiestrogen that competes with the natural estrogens for binding to the estrogen receptors...
  30. doi Ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish
    Yann Guiguen
    INRA, UR1037 SCRIBE, IFR140, Ouest genopole, F 35000 Rennes, France
    Gen Comp Endocrinol 165:352-66. 2010
    The present review focuses on the roles of estrogens and aromatase (Cyp19a1a), the enzyme needed for their synthesis, in fish gonadal sex differentiation...
  31. ncbi Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    Edward J Filardo
    Department of Surgery, Rhode Island Hospital, and Brown University, Providence, Rhode Island 02903, USA
    Mol Endocrinol 16:70-84. 2002
  32. pmc Lower-dose vs high-dose oral estradiol therapy of hormone receptor-positive, aromatase inhibitor-resistant advanced breast cancer: a phase 2 randomized study
    Matthew J Ellis
    Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    JAMA 302:774-80. 2009
    ..Estrogen deprivation therapy with aromatase inhibitors has been hypothesized to paradoxically sensitize hormone-receptor-positive breast cancer tumor cells to low-dose estradiol therapy...
  33. pmc The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study
    A Van Hylckama Vlieg
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 P, PO Box 9600, NL 2300 RC Leiden, Netherlands
    BMJ 339:b2921. 2009
    ..To assess the thrombotic risk associated with oral contraceptive use with a focus on dose of oestrogen and type of progestogen of oral contraceptives available in the Netherlands...
  34. doi Actions of estrogens on glial cells: Implications for neuroprotection
    Maria Angeles Arevalo
    Instituto Cajal, CSIC, Madrid, Spain
    Biochim Biophys Acta 1800:1106-12. 2010
    ..Acting on oligodendrocytes, astrocytes and microglia, estrogens regulate remyelination, edema formation, extracellular glutamate levels and the inflammatory response after ..
  35. ncbi Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter
    Raphaël Métivier
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Cell 115:751-63. 2003
  36. ncbi Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
    K Paech
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143 0446, USA
    Science 277:1508-10. 1997
    ..Thus, the two ERs signal in different ways depending on ligand and response element. This suggests that ERalpha and ERbeta may play different roles in gene regulation...
  37. pmc From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis
    Stavros C Manolagas
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205 7199, USA
    Endocr Rev 31:266-300. 2010
    ..Loss of estrogens or androgens decreases defense against oxidative stress in bone, and this accounts for the increased bone ..
  38. pmc Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis
    Mark D Sternlicht
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Breast Cancer Res 8:201. 2006
    ..process, termed branching morphogenesis, begins in fetal development, pauses after birth, resumes in response to estrogens at puberty, and is refined in response to cyclic ovarian stimulation once the margins of the mammary fat pad are ..
  39. pmc An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens
    M M Montano
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine, Urbana, IL 61801 3704, USA
    Proc Natl Acad Sci U S A 96:6947-52. 1999
    ..member of this superfamily, is a hormone-activated transcription factor that mediates the stimulatory effects of estrogens and the inhibitory effects of antiestrogens such as tamoxifen in breast cancer and other estrogen target cells...
  40. ncbi Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity
    S Kousteni
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic, Bone Diseases, University of Arkansas for Medical Sciences and, the Central Arkansas Veterans Health Care, System, Little Rock, AR 72205, USA
    Cell 104:719-30. 2001
  41. ncbi Estrogen-related receptor alpha1 transcriptional activities are regulated in part via the ErbB2/HER2 signaling pathway
    Eric A Ariazi
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI 53706, USA
    Mol Cancer Res 5:71-85. 2007
    ..Taken together, we conclude that ERRalpha1 phosphorylation status shows potential as a biomarker of clinical course and antihormonal- and ErbB2-based treatment options, with ERRalpha1 serving as a novel target for drug development...
  42. doi Rapid estrogen signaling in the brain
    Limor Raz
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Neurosignals 16:140-53. 2008
  43. pmc Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 t
    Luigi Cicatiello
    Dipartimento di Patologia Generale, Seconda Universita degli Studi di Napoli, 80138 Naples, Italy
    Mol Cell Biol 24:7260-74. 2004
    ..We report here that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor alpha complex to the ..
  44. pmc Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids
    Qun Pan
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL 32610, USA
    J Cell Mol Med 12:227-40. 2008
  45. pmc Differential estrogen-regulation of CXCL12 chemokine receptors, CXCR4 and CXCR7, contributes to the growth effect of estrogens in breast cancer cells
    Antoine Boudot
    UMR CNRS 6026, Molecular and Cellular Interactions, IRSET, University of Rennes 1, IFR 140, Rennes, France
    PLoS ONE 6:e20898. 2011
    CXCR4 and CXCR7 are the two receptors for the chemokine CXCL12, a key mediator of the growth effect of estrogens (E2) in estrogen receptor (ER)-positive breast cancers...
  46. pmc FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription
    Mathieu Lupien
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell 132:958-70. 2008
    ..FoxA1 translates this epigenetic signature into changes in chromatin structure thereby establishing lineage-specific transcriptional enhancers and programs...
  47. ncbi Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling
    George Reid
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    Mol Cell 11:695-707. 2003
    ..Cyclic turnover of hERalpha permits continuous responses to changes in the concentration of estradiol...
  48. doi Estrogens and atherosclerosis: insights from animal models and cell systems
    Jerzy Roch Nofer
    Center for Laboratory Medicine, University Hospital Munster, Albert Schweizer Campus 1, Gebäude A1, 48129 Munster, Germany
    J Mol Endocrinol 48:R13-29. 2012
    b>Estrogens not only play a pivotal role in sexual development but are also involved in several physiological processes in various tissues including vasculature...
  49. doi The pancreatic beta-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes
    Angel Nadal
    Instituto de Bioingeniería and CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Universidad Miguel Hernandez de Elche, Alicante, Spain
    Mol Cell Endocrinol 304:63-8. 2009
    ..This may provoke insulin resistance in the liver and muscle, as well as beta-cell exhaustion and therefore, it may contribute to the development of type II diabetes...
  50. ncbi Fate, transport, and biodegradation of natural estrogens in the environment and engineered systems
    Samir Kumar Khanal
    Departments of Civil, Construction and Environmental Engineering and Agronomy, Iowa State University, Ames, Iowa 50011 3232, USA
    Environ Sci Technol 40:6537-46. 2006
    ..such as membrane processes remove the estrogen compounds mainly through physical straining of particle-bound estrogens. Another major source, which accounts for 90% of the estrogen load, is animal manure from concentrated animal-..
  51. ncbi Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    Garnet L Anderson
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 291:1701-12. 2004
    ..Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain...
  52. pmc Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer
    Caryn S Ross-Innes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genes Dev 24:171-82. 2010
  53. pmc Biosensor zebrafish provide new insights into potential health effects of environmental estrogens
    Okhyun Lee
    Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom
    Environ Health Perspect 120:990-6. 2012
    Environmental estrogens alter hormone signaling in the body that can induce reproductive abnormalities in both humans and wildlife. Available testing systems for estrogens are focused on specific systems such as reproduction...
  54. pmc A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 31:1097-111. 2006
    ..It is particularly important to investigate the putative receptor mechanisms and brain targets for E2 to determine whether mood-enhancing effects of E2 can occur without deleterious proliferative effects in reproductive tissues...
  55. pmc The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer
    Atul Purohit
    Faculty of Medicine, Imperial College, St Mary s Hospital, London, UK
    Breast Cancer Res 4:65-9. 2002
    ..The co-ordinated stimulation of the activities of the enzymes that are involved in estrogen synthesis offers an explanation for the high concentrations of estrogens that are present in breast tumors.
  56. doi The immunomodulatory effects of estrogens: clinical relevance in immune-mediated rheumatic diseases
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:36-42. 2010
    ..Several significant factors generate confusion and opposite conclusions in evaluating the role of estrogens in these diseases, including relatively superficial translational studies from animals to the human condition, ..
  57. ncbi Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation
    Rosa Sirianni
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende, Cosenza, Italy
    Cancer Res 67:8368-77. 2007
    The aim of this study was to investigate the role of estrogens in Leydig cell tumor proliferation. We used R2C rat Leydig tumor cells and testicular samples from Fischer rats with a developed Leydig tumor...
  58. doi Estrogens maintain bone mass by regulating expression of genes controlling function and life span in mature osteoclasts
    Yuuki Imai
    Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    Ann N Y Acad Sci 1173:E31-9. 2009
    b>Estrogens play a key role in regulation of bone mass and strength by controlling activity of bone-forming osteoblasts and bone-resorbing osteoclasts...
  59. pmc The role of androgens and estrogens on healthy aging and longevity
    Astrid M Horstman
    Division of Endocrinology and Metabolism, Department of Internal Medicine, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    J Gerontol A Biol Sci Med Sci 67:1140-52. 2012
    ..If initiated carefully in the appropriate clinical population, hormone replacement therapies in men and women may prevent and reverse muscle and bone loss and functional declines and perhaps promote healthy aging and longevity...
  60. pmc Regulation of ERalpha-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: implications for breast cancer cell survival
    Melyssa R Bratton
    Tulane University School of Medicine, Department of Pharmacology, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Int J Oncol 37:541-50. 2010
    ..Collectively, our study suggests a role for ER/PI3K-AKT crosstalk in cell survival and documents the ability of AKT to regulate Bcl-2 expression via differential activation of ERalpha and ERbeta as well as regulation of GRIP1...
  61. doi Generation of a fluorescent transgenic zebrafish for detection of environmental estrogens
    Hao Chen
    Department of Molecular Genetics, Fudan University, PR China
    Aquat Toxicol 96:53-61. 2010
    To establish a novel in vivo test system for rapid detection of environmental estrogens, an ere-zvtg1: gfp transgenic zebrafish line has been generated...
  62. pmc Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer
    Jennifer Gjerde
    Hormone Laboratory, Haukeland University Hospital, Bergen, N 5021, Norway
    BMC Cancer 10:313. 2010
    ..Since tamoxifen and estrogens are both partly metabolized by these enzymes we hypothesize that a correlation between serum tamoxifen and ..
  63. pmc Androgens and estrogens in benign prostatic hyperplasia: past, present and future
    Tristan M Nicholson
    University of Rochester School of Medicine and Dentistry, Rochester, NY, United States
    Differentiation 82:184-99. 2011
    ..The prostate is an estrogen target tissue and estrogens directly and indirectly affect growth and differentiation of prostate...
  64. doi Reversibility of pre-malignant estrogen-induced epigenetic changes
    Kristy R Kutanzi
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Cell Cycle 9:3078-84. 2010
  65. doi Estrogens and gonadal function in schizophrenia and related psychoses
    Anita Riecher-Rössler
    Psychiatric University Clinic Basel, University Psychiatric Outpatient Department, c o University Hospital Basel, Petersgraben 4, Basel, 4031, Switzerland
    Curr Top Behav Neurosci 8:155-71. 2011
    Recent research has increasingly pointed to the importance of estrogens and the hypothalamic-pituitary-gonadal axis in schizophrenia...
  66. pmc Estrogen-mediated epigenetic repression of the imprinted gene cyclin-dependent kinase inhibitor 1C in breast cancer cells
    Benjamin A T Rodriguez
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 32:812-21. 2011
    ..Our findings suggest that in addition to promoter hypermethylation, epigenetic repression of tumor suppressor genes by CTCF and noncoding RNA transcripts could be more common and important than previously understood...
  67. pmc Mechanisms of estrogen signaling and gene expression via GPR30
    Eric R Prossnitz
    Department of Cell Biology and Physiology and Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Cell Endocrinol 308:32-8. 2009
    ..In this review, we will provide an overview of GPR30 function, focusing on the rapid signaling events that culminate in the transcriptional activation of certain genes...
  68. doi Estrogens, brain, and behavior: lessons from knockout mouse models
    Rachel A Hill
    Behavioral Neuroscience Laboratory, Mental Health Institute of Victoria, Parkville, Australia
    Semin Reprod Med 27:218-28. 2009 that local brain aromatase (the estrogen-synthesizing enzyme) may still convert locally produced androgens to estrogens. Hence, such "estrogen-deficient" models may not be completely void of estrogen...
  69. pmc Estrogen receptor beta: an overview and update
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Nucl Recept Signal 6:e003. 2008
    ..designated ERbeta (NR3A2), has redefined our knowledge about the mechanisms underlying cellular signaling by estrogens and has broad implications for our understanding of regulation of estrogen-responsive tissues...
  70. pmc Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women
    Faryal S Mirza
    University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Clin Endocrinol Metab 95:1991-7. 2010
    ..Sclerostin is a negative regulator of bone formation...
  71. doi Action of estrogens in the aging brain: dementia and cognitive aging
    Victor W Henderson
    Department of Health Research and Policy Epidemiology, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Biochim Biophys Acta 1800:1077-83. 2010
    Menopause is associated with sharp declines in concentrations of circulating estrogens. This change in hormone milieu has the potential to affect brain functions relevant to dementia and cognitive aging.
  72. pmc Neuroprotective effects of estrogens following ischemic stroke
    Shotaro Suzuki
    Departments of Physiology and Biophysics, and Biology, University of Washington, Seattle, WA 98195 1237, USA
    Front Neuroendocrinol 30:201-11. 2009
    ..Here we will review the discoveries comprising our current understanding of neuroprotective actions of estrogens against ischemic stroke...
  73. ncbi Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
    J P Lydon
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 9:2266-78. 1995
    ..Collectively, these results provide direct support for progesterone's role as a pleiotropic coordinator of diverse reproductive events that together ensure species survival...
  74. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
    ..estrogenic chemicals is very limited, the estrogenic potency of phytoestrogens is significant, especially for ER beta, and they may trigger many of the biological responses that are evoked by the physiological estrogens.
  75. ncbi Production and actions of estrogens
    Christian J Gruber
    Department of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna Medical School, Vienna, Austria
    N Engl J Med 346:340-52. 2002
  76. pmc Structural basis for androgen specificity and oestrogen synthesis in human aromatase
    Debashis Ghosh
    Structural Biology, Hauptman Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, New York 14203, USA
    Nature 457:219-23. 2009
    ..The molecular basis for the enzyme's androgenic specificity and unique catalytic mechanism can be used for developing next-generation aromatase inhibitors...
  77. ncbi Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism
    Marina Brama
    Department of Biochemical Sciences, University La Sapienza, P le A Moro 5, 00185 Roma, Italy
    Mol Cell Endocrinol 264:102-8. 2007
    ..Cadmium (Cd) a toxic pollutant, acts as estrogens in BC cells...
  78. pmc Estrogen regulation of apoptosis: how can one hormone stimulate and inhibit?
    Joan S Lewis-Wambi
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res 11:206. 2009
    ..This finding has implications for the control of breast cancer with low-dose estrogen and other targeted therapeutic drugs...
  79. doi Regulation of estrogen rapid signaling through arginine methylation by PRMT1
    Muriel Le Romancer
    INSERM, U590, Lyon F 69008, France Université de Lyon, Lyon 1, ISPB and IFR62, Lyon F 69003, France
    Mol Cell 31:212-21. 2008
    ..Our data indicate that the methylation of ERalpha is a physiological process occurring in the cytoplasm of normal and malignant epithelial breast cells and that ERalpha is hypermethylated in a subset of breast cancers...
  80. pmc Universal assay of vitellogenin as a biomarker for environmental estrogens
    S A Heppell
    Department of Zoology, North Carolina State University, Raleigh, Raleigh 27695, USA
    Environ Health Perspect 103:9-15. 1995
    ..the serum phospholipoglycoprotein precursor to egg yolk, is potentially an ideal biomarker for environmental estrogens. This study was undertaken to develop antibodies against conserved regions on the VTG molecule that could form ..
  81. ncbi Estrogen actions throughout the brain
    Bruce McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Recent Prog Horm Res 57:357-84. 2002
    ..It is also likely that estrogens may locally regulate events at the sites of synaptic contact in the excitatory pyramidal neurons where the ..
  82. ncbi Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements
    Julie M Hall
    Receptor Biology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 16:469-86. 2002
  83. pmc Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM
    Simeen Malik
    Department of Molecular and Cellular Biology, 3 Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 30:399-412. 2010
  84. ncbi Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin
    R K Ross
    University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9181, USA
    J Natl Cancer Inst 92:328-32. 2000
    ..Few data exist on the association between CHRT and breast cancer risk. We determined the effects of CHRT on a woman's risk of developing breast cancer in a population-based, case-control study...
  85. ncbi Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects
    N E Skakkebaek
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Hum Reprod 16:972-8. 2001
    ..Otherwise, important biological information may be lost...
  86. ncbi The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta
    L K Saxon
    Department of Orthopaedic Surgery, Indiana University Purdue University, Indianapolis, USA
    Am J Physiol Endocrinol Metab 293:E484-91. 2007
    ..001). We conclude that estrogen signaling through ER-beta suppresses the mechanical loading response on the periosteal surface of long bones...
  87. ncbi Bone remodeling in post-menopausal osteoporosis
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
    J Dent Res 85:584-95. 2006
  88. ncbi Vascular effects of estrogens: arterial protection versus venous thrombotic risk
    M P Bracamonte
    Dept of Physiology and Biophysics, Mayo Clinic, 55905, Rochester, MN, USA
    Trends Endocrinol Metab 12:204-9. 2001
  89. ncbi Rapid and reversible inhibition of brain aromatase activity
    J Balthazart
    Center for Research in Cellular and Molecular Neurobiology, Research Group in Behavioural Neuroendocrinology, University of Liege, Liege, Belgium
    J Neuroendocrinol 13:63-73. 2001
  90. pmc Collapse of a fish population after exposure to a synthetic estrogen
    Karen A Kidd
    Fisheries and Oceans Canada, Freshwater Institute, 501 University Crescent, Winnipeg, Manitoba, Canada R3T 2N6
    Proc Natl Acad Sci U S A 104:8897-901. 2007
    Municipal wastewaters are a complex mixture containing estrogens and estrogen mimics that are known to affect the reproductive health of wild fishes...
  91. ncbi Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells
    Xiaofei Wang
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Mol Pharmacol 70:395-404. 2006
    Neuroprotective effects of estrogens have been shown in various in vitro and in vivo models, but the mechanisms underlying protection by estrogen are not clear...
  92. ncbi Androgens and estrogens induce seasonal-like growth of song nuclei in the adult songbird brain
    Anthony D Tramontin
    Department of Neurosurgery Research, University of California, San Francisco, California 94143, USA
    J Neurobiol 57:130-40. 2003
    ..These data also suggest that T's effects on seasonal song nucleus growth may depend, in part, upon enzymatic conversion of T to bioactive metabolites...
  93. ncbi Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
    Jason S Carroll
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cell 122:33-43. 2005
    ..Furthermore, knockdown of FoxA1 expression blocks the association of ER with chromatin and estrogen-induced gene expression demonstrating the necessity of FoxA1 in mediating an estrogen response in breast cancer cells...
  94. pmc Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
    T Simoncini
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 407:538-41. 2000
    ..Our findings define a physiologically important non-nuclear oestrogen-signalling pathway involving the direct interaction of ER alpha with PI(3)K...
  95. doi Control of mammary stem cell function by steroid hormone signalling
    Marie Liesse Asselin-Labat
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Nature 465:798-802. 2010
    ..These findings further indicate that breast cancer chemoprevention may be achieved, in part, through suppression of MaSC function...
  96. pmc Estrogen in the adult male reproductive tract: a review
    Rex A Hess
    Department of Veterinary Biosciences, Reproductive Biology and Toxicology, University of Illinois, Urbana, IL 61802, USA
    Reprod Biol Endocrinol 1:52. 2003
    ..Thus, we conclude that estrogen or its alpha-receptor is an absolute necessity for fertility in the male...
  97. ncbi Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition
    R Kaaks
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Endocr Relat Cancer 12:1071-82. 2005
    ..The results from this study caution against the use of DHEA(S), or other androgens, for postmenopausal androgen replacement therapy...
  98. pmc Estrogen directly activates AID transcription and function
    Siim Pauklin
    DNA Editing Laboratory, Cancer Research UK, Clare Hall Laboratories, South Mimms, EN6 3LD, England, UK
    J Exp Med 206:99-111. 2009
    ..We therefore suggest that estrogen-induced autoimmunity and oncogenesis may be derived through AID-dependent DNA instability...
  99. pmc The role of estrogen in the initiation of breast cancer
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Steroid Biochem Mol Biol 102:89-96. 2006
    b>Estrogens are considered to play a major role in promoting the proliferation of both the normal and the neoplastic breast epithelium...
  100. pmc Estrogen and mechanisms of vascular protection
    Dongqi Xing
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Arterioscler Thromb Vasc Biol 29:289-95. 2009
  101. ncbi Estrogen and spermatogenesis
    Prince Henry s Institute of Medical Research, Victoria, Australia
    Endocr Rev 22:289-318. 2001
    ..estrogen exposure to perturb spermatogenesis and male fertility, as well as the emerging physiological role of estrogens in male fertility, suggesting that, in this local context, estrogenic substances should also be considered "male ..

Research Grants79

  1. Effects of herbs on transcription and cell proliferation
    Dale Leitman; Fiscal Year: 2003
    Multiple lines of evidence indicate that estrogens promote breast cancer, Selective estrogen receptor modulators (SERMs), such as tamoxifen are first-line drugs used as adjuvant therapy for preventing recurrences and reducing mortality ..
  2. Xenoestrogen regulation of Leydig cells
    ..Research training to be afforded by the present application to professional veterinary students will contribute to efforts geared to preparing future veterinarians to meet these challenges. ..
  3. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
    ..It was here that I noted in preclinical studies that estrogens suppress orexin activity and that ina recent clinical study dramatic loss of estrogen during menopause leads to ..
    Carole R Mendelson; Fiscal Year: 2013
  5. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
  6. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    ..The studies would also lead to the identification of biomarkers that would be useful in clinical trials. ..
  7. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..Circulating T and DHT also serve as precursors of estrogens through their conversion to estradiol and estrone by aromatase...
  8. 5-HT transporter function: Interaction of hormones and antidepressants
    Alan Frazer; Fiscal Year: 2013
    ..Our basic research studies could have treatment implications for patients with either MDD and/or PTSD. ..
    Chella David; Fiscal Year: 2009
    ..The findings would shed light on the role of immune system in health and disease and may identify new therapeutic approaches for arthritis. ..
  10. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..This type of infertility exhibits excess estrogen production without ovulation that can lead to polycystic ovary syndrome, irregular vaginal bleeding, metabolic abnormalities as well as endometrial polyps, hyperplasia, and even cancer. ..
  11. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
  12. Axonopathy in Glaucoma
    Samuel D Crish; Fiscal Year: 2013
    ..This proposal is designed with the goal of identifying new therapeutic targets for this disease as well as identifying the potential role that function-restoring therapies could play in glaucoma and other neurodegenerative diseases. ..
  13. Sex Steroid Hormone Regulation of Drug Reinforcement
    Diane Lebesgue; Fiscal Year: 2012
    ..Indeed, sex differences in drug abuse liability are well documented, and there is growing evidence that estrogens potentiate drug reinforcement...
  14. Central Action of Brain-Derived Neurotrophic Factor in Male and Female Rats
    Haifei Shi; Fiscal Year: 2010
  15. Mechanisms of Sex Determination in Zebrafish
  16. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..These assays will provide a novel diagnostic/prognostic tools and serve as "safety biomarkers." according to the FDA. ..
  17. Metabolic mechanisms of antiestrogen resistance in breast cancer
    ..I hope to become a physician scientist who links the laboratory and clinical research aspects to improve the lives of patients with breast cancer. 1 ..
  18. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
  19. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..There is evidence that estrogens in the form of hormone therapy (HT) can reduce abdominal fat accumulation...
  20. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Estrogens play a central role in the brain's regulation of reproductive behavior, sexual development and cognitive processes such as learning and memory formation...
  21. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
  22. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..e. use of estrogen receptor therapeutics as viable approaches to improve ischemic tolerance in aged women. ..
  23. Regulation of NFkappaB activity by the Estrogen Receptor
    Kendall W Nettles; Fiscal Year: 2012
    ..ER suppression of NFB is critical for protective effects of estrogens in inflammatory bowel disease, sepsis, arthritis, atherosclerosis, and lipid metabolism, highlighting the broad ..
  24. Runx Proteins and Sex Steroid Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2009
    ..Specific Aim 3 is to test the ability of estrogens (and later androgens) to correct the hyper-osteoclastogenic phenotype of osteoblasts over- expressing Runx2 in ..
  25. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    ..Furthermore, we will develop a new methodology that will be critical for examining epigenetic changes in gene expression in a temporal and spatial manner in neural tissue with heterogeneous cell populations. ..
  26. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
  27. Epigenetic effects of developmental endocrine disruptor exposure in the ovary
    Mehmet Uzumcu; Fiscal Year: 2010
    ..A mechanistic understanding of the epigenetic effects of EDC exposure can lead to better prevention, diagnosis, and therapies, thereby improving public health and reducing health care costs. ..
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    ..Overall, reproductive experience-induced shifts in endocrine activities may affect endocrine-related diseases and behaviors later in adulthood, i.e. breast cancer, autoimmune diseases, and postpartum mood disorders. ..
  29. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
  30. Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
    ANNE LOUISE SCHAFER; Fiscal Year: 2013
    ..Dr. Schafer is committed to improving the health care of veterans through clinical research, and the CDA-2 is critical for the attainment of her career objectives. ..
    ANN NARDULLI; Fiscal Year: 2013
    ..b>Estrogens and selective estrogen receptor modulators are widely used in regulating fertility, alleviating postmenopausal ..
  32. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..This project may allow disclose novel targets for development of more effective anti-resorptive therapies for osteoporosis and related disease. Thus, this project is highly relevant to the VA patient care mission. ..
  33. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..Health Initiative study which found a negative consequence of using UNPHYSIOLOGICAL conjugated equine estrogens. The above data indicate that the decline in circulating physiological sex steroids at menopause and during ..
  34. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..Knowledge gained from this study may also have application to other diseases across the age spectrum that are associated with bone loss and involve alterations in bone marrow composition. ..
    Walter C Willett; Fiscal Year: 2010
    ..The findings will contribute importantly to the prevention and prognosis of major cancers of men and women. ..
  36. Somatic Stem Cells in Engineered Human Skin
    Steven Boyce; Fiscal Year: 2009
  37. Regulation of vasculature by estrogen receptors during aging in mouse models
    Margaret Markiewicz; Fiscal Year: 2013
    ..This may lead to future discovery of a new therapeutic intervention for cardiovascular and cerebrovascular diseases. ..
  38. Transgenerational effects of maternal high fat diet during pregnancy on breast ca
    Leena A Hilakivi-Clarke; Fiscal Year: 2013
  39. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..need for new and safer estrogen therapies (ET) to treat the symptoms associated with low levels or a lack of estrogens, including decreased sexual motivation, hot flushes, sleep disorders, depression/anxiety, brain and spinal cord ..
  40. Exploratory Studies on the Anti-Breast Cancer Function of Bamboo Extract
    Jun Panee; Fiscal Year: 2010
    ..also enhanced the activity of sulfotransferases (SULT) in the liver, an enzyme family that conjugates estrogens. The preliminary results indicate that BEX may affect the functions of multiple tissues that synergistically ..
  41. Sex-Hormones and the TMPRSS2: ERG Fusion in Prostate Cancer Progression
    Lorelei Mucci; Fiscal Year: 2013
    ..The regulation of TMPRSS2 by androgens and possibly estrogens is intriguing and illuminates a potential mechanism whereby sex hormones could drive tumor growth and ..
  42. Parental age at birth and risk of adult-onset cancer in female offspring
    Yani Lu; Fiscal Year: 2013
    ..Biological evidence of higher levels of circulating estrogens with advancing gestational age and higher chance of germ cell mutations and DNA damage from older fathers (but ..
  43. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    b>Estrogens affect a wide variety of processes in the brain and many aspects of behavior including social interactions, reproduction, and memory...
  44. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2010
  45. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..Current therapies include estrogen or hormone (estrogens + progestins) therapies (ERT and HRT), clonidine, the selective serotonin and/or norepinephrine reuptake ..
  46. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    Veena Taneja; Fiscal Year: 2013
    ..The findings would shed light on the role of MHC, immune system in health and disease and may identify new therapeutic approaches for arthritis. ..
  48. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    ..The current proposal is focusing on determining androgen downstream target genes and subsequent signaling network during the process of inguinoscrotal testis descent, which may provide new insight into the causes of testis maldescent. ..
  49. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..By elucidating the interacting impact of declining ovarian and adrenal steroids on CNS function, we expect to lay a foundation for the development of therapies for many aging-associated disorders in women. ..
  50. Sex Steroids and Runx Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2013
    ..They will decipher cryptic mechanisms of action of existing SERMs, and support the rationale development of novel ones, based on their influence on Runx proteins. ..
  51. Endocrine Targets for Prevention of Lung Cancer
    Robert M Bigsby; Fiscal Year: 2012, we will determine which of the three estrogen receptor types mediate the tumor promoter action of estrogens. In this way we can identify the precise target(s) for future development of antiestrogens that can be used ..
  52. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    ..Understanding the differences in autoimmune disease risk in men and women, and how hormones affects autoimmunity may lead to novel hormone-based therapies, and insights into this essential riddle in autoimmune disease. ..
  53. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..The development of a viable non-toxic chemoprevention strategy targeting high risk women could have a significant impact on breast cancer morbidity and mortality. ..
  54. Theranostic Nanomedicine for Breast Cancer Prevention and Image-Guided Therapy
    Prakash R Rai; Fiscal Year: 2011
    ..Nanotechnology has made major contributions to BrCa therapy. We propose an innovative nanotechnology-based approach for BrCa prevention and treatment that could significantly impact patient care. ..
  55. Estrogens, androgens, aging, and bone loss in males
    Stavros C Manolagas; Fiscal Year: 2013
    ..Conversely, estrogens or non-aromatizable androgens decrease oxidative stress...
  56. Vascular Surgery - Estrogen and the Injury Response
    Richard H Karas; Fiscal Year: 2012
  57. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
  58. Modulation of Colonic Epithelial Permeability by Sex Hormones
    Muriel Larauche; Fiscal Year: 2013
    ..and secretion in IBS and enable the candidate to propose new testable hypotheses regarding mechanisms of IBS pain and constipation, in particular regarding differential treatment approaches based on pathophysiology and sex differences ..
  59. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..This proposal may improve the application of anti-atherosclerosis agents and lead to development of new agents to protect blood vessels from atherosclerosis and its complications. ..
  60. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
  61. Regulation Of Inorganic Phosphorus (Pi) Metabolism By Estrogen
    Hassane Amlal; Fiscal Year: 2013
    ..This effect should be considered when prescribing estrogen, and this hormone can also be used when blood level of Pi is high (hyperphosphatemia). ..
  62. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..An understanding of the fetal mechanisms associated with sex differences in MOD will have etiologic imolications and imoortance for the development of sex-specific treatments and prevention of MOD. ..
  63. The Role of Sex in Self Antigen Generation in SLE
    David Stephen Pisetsky; Fiscal Year: 2010
    ..Studies on the effects of sex influence on conditions such as shock and sepsis suggest, however, that estrogens may modulate macrophage function and thereby influence the clearance process...
  64. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..A regulatory mechanism is proposed that could lead to a novel treatment in psychiatric illnesses with explosive rage and impulse disorders. ..
    Sreenivas Koka; Fiscal Year: 1999
    ..Identification of the mechanisms by which estrogen regulates IL-6 gene expression will enhance our understanding of the pathobiology of osteoporosis and suggest future strategies aimed at treating and preventing this disease. ..
  66. Biotransformation of Estrogens to Carcinogenic Quinoids
    JUDY BOLTON; Fiscal Year: 2005
    DESCRIPTION: There is a clear association between excessive exposure to estrogens and the development of cancer in several tissues including breast and endometrium...
  67. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..In mice, steroidal estrogens can inhibit anti-myelin helper T-lymphocyte responses and suppress EAE...
  68. A Novel Function of the Oocyte in Estrogen-Regulated FSH Action
    Shunichi Shimasaki; Fiscal Year: 2009
    ..The proposed studies aim to elucidate the molecular and cellular mechanisms of this finding, which may lead to develop pharmaceutical regimens for treating ovarian dysfunctions, particularly in aging women. ..
    JUDY BOLTON; Fiscal Year: 2000
    There is a clear association between excessive exposure to estrogens and the development of cancer in several tissues including breast and endometrium...
    James Shull; Fiscal Year: 2002
    b>Estrogens play a central role in the regulation of cell proliferation in numerous mammalian tissues and are inextricably implicated in the etiology of several major human cancers...
  71. Estrogen Metabolism and Action in Prostate Cancer Etiology in PCPT
    Ashraful Hoque; Fiscal Year: 2007
    ..Metaplastic growth of the prostate has been produced by estrogens combined with a constant level of androgens, but estrogens alone inhibited prostate cell growth in vitro...
  72. Interactive effects of ethanol and estrogen on brain vasopressin during puberty
    Toni R Pak; Fiscal Year: 2010
    ..disorders due to the heightened stress reactivity that occurs as a direct result of increased circulating estrogens during pubertal development...
  73. Int5/Aromatase Effect of Breast Estrogen in Neoplasia
    RAJESHWAR TEKMAL; Fiscal Year: 2005
    ..These changes are persistent even without circulating ovarian estrogens. We have also shown that: aromatase overexpression affects the expression of estrogen receptor (ER) and ..
  74. Interaction of Estrogen and Serotonin in Modulating Brain Activation in Menopause
    C Neill Epperson; Fiscal Year: 2010
    ..This application is both novel and timely as results from this study are likely to provide information critical to the on-going discussion regarding the risks and benefits of ET use in menopausal women. ..
    Preston Marx; Fiscal Year: 2007
    ..Consultant PHS 398 (Rev. 4/98) Page3 BB KK Principal Investicj^yrogram Director (Last, first, middle): RESEARCH GRANT TABLE OFCONTENTS Page Numbers Face Page 1-2 Description, ..
  76. Interactions Between Dietary Soy Components & Tamoxifen
    Jin Rong Zhou; Fiscal Year: 2003
    ..that are related to estrogen-pathways such as tumor expressions of ER(alpha), ER(beta) and serum levels of estrogens. We will then quantify tumor proliferation index by PCNA staining and apoptotic index by TUNEL assay...
    Rex Hess; Fiscal Year: 2000
    ..This research will provide basic information that will allow us to study disease processes that target the head of the epididymis and lead to male infertility. ..
    Dominique Toran Allerand; Fiscal Year: 2000
  79. Development of an animal model to study how to prevent progression of hormone dep
    Gudmundur Thordarson; Fiscal Year: 2009
    ..abstract_text> ..