endocannabinoids

Summary

Summary: Endogenous compounds that bind to CANNABINOID RECEPTORS. They are structurally different from the CANNABINOIDS which are primarily derived from plants.

Top Publications

  1. ncbi The molecular logic of endocannabinoid signalling
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nat Rev Neurosci 4:873-84. 2003
  2. ncbi Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids
    Veronique M Andre
    Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, NPI 58 258, Los Angeles, CA 90095, USA
    Eur J Neurosci 31:14-28. 2010
  3. pmc The endocannabinoid system as an emerging target of pharmacotherapy
    Pal Pacher
    Laboratory of Physiological Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2S 24, Bethesda, MD 20892 9413, USA
    Pharmacol Rev 58:389-462. 2006
  4. ncbi The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide
    Jesse Lo Verme
    Department of Pharmacology, 360 MSRII, University of California, Irvine, CA 92697 4625, USA
    Mol Pharmacol 67:15-9. 2005
  5. ncbi Role of endogenous cannabinoids in synaptic signaling
    Tamas F Freund
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 8, Szigony u 43, H 1083 Hungary
    Physiol Rev 83:1017-66. 2003
  6. ncbi Identification and functional characterization of brainstem cannabinoid CB2 receptors
    Marja D Van Sickle
    Institute of Infection, Immunity, and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1
    Science 310:329-32. 2005
  7. ncbi CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
    Science 302:84-8. 2003
  8. pmc The orphan receptor GPR55 is a novel cannabinoid receptor
    E Ryberg
    Department of Lead Generation, AstraZeneca R and D, Molndal, Sweden
    Br J Pharmacol 152:1092-101. 2007
  9. ncbi Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury
    Tiziana Genovese
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    J Pharmacol Exp Ther 326:12-23. 2008
  10. pmc Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    Douglas Osei-Hyiaman
    National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:1298-305. 2005

Detail Information

Publications422 found, 100 shown here

  1. ncbi The molecular logic of endocannabinoid signalling
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nat Rev Neurosci 4:873-84. 2003
  2. ncbi Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids
    Veronique M Andre
    Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, NPI 58 258, Los Angeles, CA 90095, USA
    Eur J Neurosci 31:14-28. 2010
    ..These effects were fully (D1 cells) or partially (D2 cells) mediated through retrograde signaling via endocannabinoids. A cannabinoid 1 receptor (CB1R) agonist and a blocker of anandamide transporter prevented the D1 receptor-..
  3. pmc The endocannabinoid system as an emerging target of pharmacotherapy
    Pal Pacher
    Laboratory of Physiological Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2S 24, Bethesda, MD 20892 9413, USA
    Pharmacol Rev 58:389-462. 2006
    ..by treatment with a CB(1) receptor antagonist, such as in obesity, and may also be absent when the action of endocannabinoids is enhanced indirectly through blocking their metabolism or transport...
  4. ncbi The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide
    Jesse Lo Verme
    Department of Pharmacology, 360 MSRII, University of California, Irvine, CA 92697 4625, USA
    Mol Pharmacol 67:15-9. 2005
    ..These findings indicate that PPAR-alpha mediates the anti-inflammatory effects of PEA and suggest that this fatty-acid ethanolamide may serve, like its analog OEA, as an endogenous ligand of PPAR-alpha...
  5. ncbi Role of endogenous cannabinoids in synaptic signaling
    Tamas F Freund
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 8, Szigony u 43, H 1083 Hungary
    Physiol Rev 83:1017-66. 2003
    ..by remarkable discoveries including identification of endogenous compounds with cannabimimetic activity (endocannabinoids) and the cloning of their molecular targets, the CB1 and CB2 receptors...
  6. ncbi Identification and functional characterization of brainstem cannabinoid CB2 receptors
    Marja D Van Sickle
    Institute of Infection, Immunity, and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1
    Science 310:329-32. 2005
    ..were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors...
  7. ncbi CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
    Science 302:84-8. 2003
    ..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
  8. pmc The orphan receptor GPR55 is a novel cannabinoid receptor
    E Ryberg
    Department of Lead Generation, AstraZeneca R and D, Molndal, Sweden
    Br J Pharmacol 152:1092-101. 2007
    ..Work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in a number of physiological processes...
  9. ncbi Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury
    Tiziana Genovese
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    J Pharmacol Exp Ther 326:12-23. 2008
    ..Together, the results indicate that PEA reduces inflammation and tissue injury associated with SCI and suggest a regulatory role for endogenous PPAR-alpha signaling in the inflammatory response associated with spinal cord trauma...
  10. pmc Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    Douglas Osei-Hyiaman
    National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:1298-305. 2005
    ..diet-induced obesity even though their caloric intake is similar to that of wild-type mice, suggesting that endocannabinoids also regulate fat metabolism...
  11. pmc Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
    Jonathan Z Long
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Chem Biol 5:37-44. 2009
    2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the cannabinoid receptors CB1 and CB2...
  12. pmc International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Pharmacol Rev 62:588-631. 2010
    ..phytocannabinoid Δ(9)-tetrahydrocannabinol, numerous synthetic compounds, and endogenous compounds known as endocannabinoids. Cannabinoid receptor antagonists have also been developed...
  13. pmc Endocannabinoid signal in the gut controls dietary fat intake
    Nicholas V DiPatrizio
    Department of Pharmacology, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:12904-8. 2011
    ..Collectively, the results suggest that the endocannabinoid system in the gut exerts a powerful regulatory control over fat intake and might be a target for antiobesity drugs...
  14. pmc The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
    William R Marrs
    Neurobiology and Behavior Graduate Program, University of Washington, Seattle, Washington, USA
    Nat Neurosci 13:951-7. 2010
    ..Our results indicate that ABHD6 is a rate-limiting step of 2-AG signaling and is therefore a bona fide member of the endocannabinoid signaling system...
  15. pmc Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 334:809-13. 2011
    ....
  16. ncbi Endocannabinoids mediate neuron-astrocyte communication
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Neuron 57:883-93. 2008
    ..These receptors are activated by endocannabinoids released by neurons, increasing astrocyte Ca2+ levels, which stimulate glutamate release that activates NMDA ..
  17. pmc Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections
    Chia Shan Wu
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Eur J Neurosci 32:693-706. 2010
    ..In summary, our study provides strong evidence that endocannabinoids are a modulator for the proposed 'handshake' interactions between corticothalamic and thalamocortical axons, ..
  18. pmc Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids
    Martin Rossmeisl
    Department of Adipose Tissue Biology, Institute of Physiology Academy of Sciences of the Czech Republic v v i, Prague, Czech Republic
    PLoS ONE 7:e38834. 2012
    ..We hypothesised that the latter effect will be more pronounced when DHA/EPA is supplemented as phospholipids rather than as triglycerides...
  19. pmc Brain monoglyceride lipase participating in endocannabinoid inactivation
    T P Dinh
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Proc Natl Acad Sci U S A 99:10819-24. 2002
    The endogenous cannabinoids (endocannabinoids) are lipid molecules that may mediate retrograde signaling at central synapses and other forms of short-range neuronal communication...
  20. pmc The endocannabinoid system links gut microbiota to adipogenesis
    Giulio G Muccioli
    Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Mol Syst Biol 6:392. 2010
    ..These data indicate that gut microbiota determine adipose tissue physiology through LPS-eCB system regulatory loops and may have critical functions in adipose tissue plasticity during obesity...
  21. pmc Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
    Matthias Bluher
    University of Leipzig, Medical Department III, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes 55:3053-60. 2006
    ..We determined whether circulating endocannabinoids are related to visceral adipose tissue mass in lean, subcutaneous obese, and visceral obese subjects (10 men ..
  22. ncbi A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
    Raquel Gomez
    University Institute of Drug Dependencies, Department of Psychobiology, University Complutense of Madrid, Madrid 28223, Spain
    J Neurosci 22:9612-7. 2002
    ..Despite the existence of central mechanisms for the regulation of food intake by endocannabinoids, evidence indicates that peripheral mechanisms may also exist...
  23. pmc Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol
    Tim C Kirkham
    Department of Psychology, University of Reading, Earley Gate, Whiteknights, Reading RG6 6AL, UK
    Br J Pharmacol 136:550-7. 2002
    b>Endocannabinoids are implicated in appetite and body weight regulation. In rodents, anandamide stimulates eating by actions at central CB1 receptors, and hypothalamic endocannabinoids may be under the negative control of leptin...
  24. ncbi Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
    B F Cravatt
    Department of Chemistry, The Scripps Research Institute, La Jolla, California 92307, USA
    Nature 384:83-7. 1996
    ..Therefore we will hereafter refer to oleamide hydrolase as fatty-acid amide hydrolase, in recognition of the plurality of fatty-acid amides that the enzyme can accept as substrates...
  25. ncbi Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    R I Wilson
    Nature 410:588-92. 2001
    ..Signalling by the endocannabinoid system thus represents a mechanism by which neurons can communicate backwards across synapses to modulate their inputs...
  26. ncbi Intracellular trafficking of anandamide: new concepts for signaling
    Mauro Maccarrone
    Department of Biomedical Sciences, University of Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy
    Trends Biochem Sci 35:601-8. 2010
    b>Endocannabinoids are key mediators of many aspects of human health and disease...
  27. pmc Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
    Carlos Solorzano
    Department of Pharmacology, University of California, Irvine, CA 92697 4624, USA
    Proc Natl Acad Sci U S A 106:20966-71. 2009
    ..The PEA-hydrolyzing amidase NAAA may provide a previously undescribed target for antiinflammatory medicines...
  28. pmc Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
    Tiziana Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, 80078 Pozzuoli, Italy
    J Cell Biol 163:463-8. 2003
    ..This switch provides a possible explanation for a fundamental change in endocannabinoid function during brain development. Identification of these enzymes may offer new therapeutic opportunities for a wide range of disorders...
  29. ncbi Endocannabinoid signaling and long-term synaptic plasticity
    Boris D Heifets
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Annu Rev Physiol 71:283-306. 2009
    b>Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic transmission throughout the central nervous system. Accordingly, eCBs are involved in neural functions ranging from feeding homeostasis to cognition...
  30. ncbi Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide
    R A Ross
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
    Eur J Pharmacol 401:121-30. 2000
    ..In contrast, the inhibition by palmitoylethanolamide does not appear to be mediated by cannabinoid receptors...
  31. pmc TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
    Andres E Chavez
    Department of Neuroscience, Albert Einstein College of Medicine, New York, New York, USA
    Nat Neurosci 13:1511-8. 2010
    ..Thus, our findings reveal a previously unknown form of endocannabinoid- and TRPV1-mediated regulation of synaptic strength at central synapses...
  32. ncbi Depolarization-induced suppression of inhibition mediated by endocannabinoids at synapses from fast-spiking interneurons to medium spiny neurons in the striatum
    Madoka Narushima
    Department of Cellular Neuroscience, Osaka University, Graduate School of Medicine, Yamada oka, Suita 565 0871, Japan
    Eur J Neurosci 24:2246-52. 2006
    Endogenous cannabinoids (endocannabinoids) act as retrograde inhibitory messengers in various regions of the brain...
  33. ncbi Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Brain Behav Immun 25:1099-112. 2011
    ....
  34. pmc N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
    Douglas McHugh
    The Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    BMC Neurosci 11:44. 2010
    ..Here, we investigate the relationship between NAGly, Abn-CBD, the unidentified 'Abn-CBD' receptor, GPR18, and BV-2 microglial migration...
  35. pmc The case for peripheral CB₁ receptor blockade in the treatment of visceral obesity and its cardiometabolic complications
    George Kunos
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9413, USA
    Br J Pharmacol 163:1423-31. 2011
    In this review, we consider the role of endocannabinoids and cannabinoid-1 (CB(1)) cannabinoid receptors in metabolic regulation and as mediators of the thrifty phenotype that underlies the metabolic syndrome...
  36. pmc Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA
    Nat Neurosci 13:1113-9. 2010
    ..Thus, individual endocannabinoids generate distinct analgesic profiles that are either sustained or transitory and associated with agonism and ..
  37. ncbi Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels
    Vincenzo Micale
    Department of Experimental and Clinical Pharmacology, University of Catania Medical School, Catania, Italy
    Neuropsychopharmacology 34:593-606. 2009
    ..Simultaneous 'indirect' activation of CB(1) receptors following FAAH inhibition, and antagonism at TRPV1 receptors might represent a new therapeutic strategy against anxiety...
  38. ncbi Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats
    Barbara Batetta
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Cagliari, Cagliari 09100, Italy
    J Nutr 139:1495-501. 2009
    ..These effects were associated with a lower concentration of the endocannabinoids, anandamide and 2-arachidonoylglycerol, in the visceral adipose tissue and of anandamide in the liver and ..
  39. ncbi Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease
    S E O'Sullivan
    School of Graduate Entry Medicine and Health, University of Nottingham, Nottingham, UK
    Immunobiology 215:611-6. 2010
    ..The major endocannabinoids, anandamide and 2-arachidonoylglycerol, and ajulemic acid, a structural analogue of the phytocannabinoid ..
  40. ncbi Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
    Vivien Chevaleyre
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 38:461-72. 2003
    ..receptors at CA1 pyramidal cells, triggering a persistent reduction of GABA release that is mediated by endocannabinoids. This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with ..
  41. ncbi Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
    Fabricio A Moreira
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, D 55099 Mainz, Germany
    Neuropharmacology 54:141-50. 2008
    Anandamide and 2-arachidonoyl glycerol, referred to as endocannabinoids (eCBs), are the endogenous agonists for the cannabinoid receptor type 1 (CB1)...
  42. ncbi Endocannabinoid signaling as a synaptic circuit breaker in neurological disease
    Istvan Katona
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H 1083 Budapest, Hungary
    Nat Med 14:923-30. 2008
    ....
  43. ncbi Hardwiring the brain: endocannabinoids shape neuronal connectivity
    Paul Berghuis
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    Science 316:1212-6. 2007
    ..b>Endocannabinoids trigger CB(1)R internalization and elimination from filopodia and induce chemorepulsion and collapse of ..
  44. ncbi Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Neuron 68:113-26. 2010
    b>Endocannabinoids and their receptor CB1 play key roles in brain function. Astrocytes express CB1Rs that are activated by endocannabinoids released by neurons...
  45. ncbi Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum
    Motokazu Uchigashima
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 27:3663-76. 2007
    Endogenous cannabinoids (endocannabinoids) mediate retrograde signals for short- and long-term suppression of transmitter release at synapses of striatal medium spiny (MS) neurons...
  46. ncbi The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Italy
    Pain 139:541-50. 2008
    ..The findings presented here, in addition to prove the beneficial effects of PEA in chronic pain, identify new potential targets for analgesic medicine...
  47. ncbi The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission
    Asami Tanimura
    Department of Neurophysiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Neuron 65:320-7. 2010
    b>Endocannabinoids are released from postsynaptic neurons and cause retrograde suppression of synaptic transmission. Anandamide and 2-arachidonoylglycerol (2-AG) are regarded as two major endocannabinoids...
  48. pmc Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance
    Ulrike Taschler
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 286:17467-77. 2011
    ..Defective degradation of 2-AG does not provoke cannabinoid-like effects on feeding behavior, lipid storage, and energy expenditure, which may be explained by desensitization of CBR...
  49. ncbi Modulation of anxiety through blockade of anandamide hydrolysis
    Satish Kathuria
    Department of Pharmacology, University of California, Irvine, California, USA
    Nat Med 9:76-81. 2003
    ..Our results indicate that anandamide participates in the modulation of emotional states and point to fatty acid amide hydrolase inhibition as an innovative approach to anti-anxiety therapy...
  50. pmc Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice
    Bin Pan
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurosci 31:13420-30. 2011
    ..These results indicate that genetic deletion of MAGL causes profound changes in eCB signaling, long-term synaptic plasticity, and learning behavior...
  51. pmc Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
    Wen Jiang
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Clin Invest 115:3104-16. 2005
    ....
  52. ncbi Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum
    Anatol C Kreitzer
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Neuron 34:787-96. 2002
    b>Endocannabinoids serve as retrograde messengers in many brain regions. These diffusible lipophilic molecules are released by postsynaptic cells and regulate presynaptic neurotransmitter release...
  53. ncbi The endocannabinoid system in obesity and type 2 diabetes
    V Di Marzo
    Endocannabinoid Research Group at the Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, 80078, Pozzuoli NA, Italy
    Diabetologia 51:1356-67. 2008
    b>Endocannabinoids (ECs) are defined as endogenous agonists of cannabinoid receptors type 1 and 2 (CB1 and CB2). ECs, EC anabolic and catabolic enzymes and cannabinoid receptors constitute the EC signalling system...
  54. pmc Endocannabinoid-dependent plasticity at spinal nociceptor synapses
    Ako Kato
    Institute of Pharmacology and Toxicology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Physiol 590:4717-33. 2012
    ..Both findings may have important implications for our understanding of endogenous pain control mechanisms and of analgesia evoked by cannabinoid receptor agonists...
  55. ncbi The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
    Pharmacol Res 60:77-84. 2009
    ..principle of the hemp plant Cannabis sativa; (2) the endogenous agonists at these receptors, known as endocannabinoids, of which anandamide and 2-arachidonoylglycerol are the best known; and (3) proteins and enzymes for the ..
  56. ncbi A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation
    Thien P Dinh
    Department of Pharmacology, University of California, 360 Med Surge II, Irvine, CA 92697 4625, USA
    Chem Phys Lipids 121:149-58. 2002
    ..These results indicate that hydrolysis via MGL may be a primary route of 2-AG inactivation in intact neuronal cells...
  57. ncbi Endocannabinoid control of food intake and energy balance
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy
    Nat Neurosci 8:585-9. 2005
    ..weight in wasting syndromes, suggesting that the CB(1) cannabinoid receptor and its endogenous ligands, the endocannabinoids, are involved in controlling energy balance...
  58. pmc Cannabinoid receptors in acute and chronic complications of atherosclerosis
    F Mach
    Department of Internal Medicine, Division of Cardiology, Geneva University Hospital, Foundation for Medical Researches, Geneva, Switzerland
    Br J Pharmacol 153:290-8. 2008
    ..For these purposes, it is important to better understand the complex mechanisms of endocannabinoid signalling and potential consequences of its pharmacological modulation, as it may have both pro- and anti-atherosclerotic effects...
  59. ncbi Anandamide uptake explained?
    Christopher J Fowler
    Department of Pharmacology and Clinical Neuroscience, Umea University, SE 901 87 Umea, Sweden
    Trends Pharmacol Sci 33:181-5. 2012
    The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol are removed from the extracellular space by a process of cellular uptake followed by metabolism...
  60. pmc Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus
    Takayuki Yoshida
    Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 108:3059-64. 2011
    ..These findings suggest that perisomatic inhibition by invaginating synapses is a key target of 2-AG-mediated control of the excitability of BA pyramidal neurons...
  61. ncbi The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders
    Mario Van Der Stelt
    Endocannabinoid Research Group, Istituto Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Bldg 70, I 80078 NA, Pozzuoli, Italy
    Eur J Pharmacol 480:133-50. 2003
    To date, N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol are the best studied endocannabinoids and are thought to act as retrograde messengers in the central nervous system (CNS)...
  62. pmc Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus
    Shi Di
    Department of Cell and Molecular Biology, 2000 Percival Stern Hall, Tulane University, New Orleans, LA 70118 5698, USA
    J Physiol 569:751-60. 2005
    ..the hypothalamic paraventricular nucleus and supraoptic nucleus (SON) respond to glucocorticoids by releasing endocannabinoids as retrograde messengers to modulate the synaptic release of glutamate...
  63. pmc Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory
    Patrizia Campolongo
    Department of Physiology and Pharmacology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Proc Natl Acad Sci U S A 106:4888-93. 2009
    ..c.). These findings indicate that endocannabinoids in the BLA enhance memory consolidation and suggest that CB1 activity within this brain region is required ..
  64. ncbi Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism
    Shi Di
    Division of Neurobiology, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118 5698, USA
    J Neurosci 23:4850-7. 2003
    ....
  65. ncbi Concerted action of CB1 cannabinoid receptor and deleted in colorectal cancer in axon guidance
    Anteneh Argaw
    University of Montreal, Montreal, Quebec H3T 1J4, Canada
    J Neurosci 31:1489-99. 2011
    b>Endocannabinoids (eCBs) are retrograde neurotransmitters that modulate the function of many types of synapses...
  66. ncbi Endocannabinoid signaling in the brain
    Rachel I Wilson
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Science 296:678-82. 2002
    ..Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism...
  67. ncbi Endocannabinoids as regulators of transient receptor potential (TRP) channels: A further opportunity to develop new endocannabinoid-based therapeutic drugs
    V Di Marzo
    Institute of Biomolecular Chemistry, Pozzuoli, Italy
    Curr Med Chem 17:1430-49. 2010
    ..out independently in two laboratories led to establish an important connection between the function of the endocannabinoids, which, as exemplified in this special issue, is per se very complex and ubiquitous in animals, and that of ..
  68. ncbi Palmitoylethanolamide protects dentate gyrus granule cells via peroxisome proliferator-activated receptor-α
    Marco Koch
    Dr Senckenbergische Anatomie, Institut für Anatomie II, Goethe Universitat, Frankfurt am Main, Germany
    Neurotox Res 19:330-40. 2011
    b>Endocannabinoids like 2-arachidonoylglycerol strongly modulate the complex machinery of secondary neuronal damage and are shown to improve neuronal survival after excitotoxic lesion...
  69. ncbi DAGL-dependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis
    Madeleine J Oudin
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Eur J Neurosci 34:1634-46. 2011
    ....
  70. pmc The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Neuron 51:455-66. 2006
    ..The endocannabinoid system tightly controls neuronal excitability. Here, we show that endocannabinoids directly target hippocampal glutamatergic neurons to provide protection against acute epileptiform seizures ..
  71. ncbi Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity
    Alessandra Quercioli
    Department of Internal Medicine, Cardiovascular Center, University Hospitals of Geneva, Geneva, Switzerland
    Eur Heart J 32:1369-78. 2011
    ..Aim of this study was to evaluate a possible association between endocannabinoid (EC) plasma levels, such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and coronary circulatory function in obesity...
  72. ncbi Cannabinoid receptors and their ligands
    R G Pertwee
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Prostaglandins Leukot Essent Fatty Acids 66:101-21. 2002
    ..Endogenous agonists for cannabinoid receptors (endocannabinoids) have also been discovered, the most important being arachidonoyl ethanolamide (anandamide), 2-arachidonoyl ..
  73. pmc Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    Biochem J 358:249-55. 2001
    ..We suggest that long-term PEA treatment of cells may positively affect the pharmacological activity of AEA, in part by inhibiting FAAH expression...
  74. ncbi Endocannabinoids in neuroimmunology and stress
    E J Carrier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Curr Drug Targets CNS Neurol Disord 4:657-65. 2005
    Two topics are presented in this review. In the first section, we review data regarding the effects of the endocannabinoids (eCBs) and cannabinoid receptors on neuroimmune function...
  75. ncbi Anandamide regulates lipopolysaccharide-induced nitric oxide synthesis and tissue damage in the murine uterus
    C A Vercelli
    Laboratory of Physiopathology of Pregnancy and Labour, Centre for Pharmacological and Botanical Studies, Paraguay 2155, Buenos Aires, Argentina
    Reprod Biomed Online 18:824-31. 2009
    ..This proinflammatory effect of anandamide may be implicated in pathological reproductive events such as septic abortion...
  76. ncbi Dual effect of anandamide on rat placenta nitric oxide synthesis
    M Cella
    Laboratory of Physiopathology of Pregnancy and Labor CEFYBO, School of Medicine, National Research Council University of Buenos Aires, Paraguay 2155, C1121ABG Buenos Aires, Argentina
    Placenta 29:699-707. 2008
    ..We hypothesized that AEA have an important implication in the normal function of placental tissues...
  77. pmc The endocannabinoid system and pain
    Josee Guindon
    Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Athens, GA 30602 3013, USA
    CNS Neurol Disord Drug Targets 8:403-21. 2009
    ..b>Endocannabinoids, the brain's own cannabis-like substances, share the same molecular target as Delta(9)-tetrahydrocannabinol, ..
  78. ncbi Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli, NA, Italy
    J Neuroimmune Pharmacol 5:103-21. 2010
    ..endogenous lipids that were originally identified in animals as agonists of CB1 and CB2 receptors, and named endocannabinoids. Over the last decade, several potential alternative receptors for phytocannabinoids, endocannabinoids, and ..
  79. ncbi Endocannabinoids render exploratory behaviour largely independent of the test aversiveness: role of glutamatergic transmission
    W Jacob
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Genes Brain Behav 8:685-98. 2009
    ..This process differentially involves endocannabinoid-controlled glutamatergic transmission, depending on the controllability of the test situation...
  80. ncbi An endocannabinoid mechanism for stress-induced analgesia
    Andrea G Hohmann
    Neuroscience and Behavior Program, Department of Psychology, The University of Georgia, Athens, Georgia 30602 3013, USA
    Nature 435:1108-12. 2005
    ..These studies also identify monoacylglycerol lipase as a previously unrecognized therapeutic target...
  81. ncbi Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum
    Takashi Maejima
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    J Neurosci 25:6826-35. 2005
    b>Endocannabinoids mediate retrograde signaling and modulate synaptic transmission in various regions of the CNS...
  82. pmc A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
    Jacqueline L Blankman
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 14:1347-56. 2007
    Endogenous ligands for cannabinoid receptors ("endocannabinoids") include the lipid transmitters anandamide and 2-arachidonoylglycerol (2-AG)...
  83. ncbi Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    Won Il Jeong
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 7:227-35. 2008
    ..We conclude that paracrine activation of hepatic CB1 receptors by stellate cell-derived 2-AG mediates ethanol-induced steatosis through increasing lipogenesis and decreasing fatty acid oxidation...
  84. ncbi Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward
    Stephen V Mahler
    Department of Psychology, The University of Michigan, Ann Arbor, MI 48109, USA
    Neuropsychopharmacology 32:2267-78. 2007
    ..Identification of an endocannabinoid hotspot for sensory pleasure gives insight into brain mechanisms of natural reward, and may be relevant to understanding the neural effects of cannabinoid drugs of abuse and therapeutic agents...
  85. ncbi Involvement of the endocannabinoid system in drug addiction
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Carrer Dr Aiguader 80, 08003 Barcelona, Spain
    Trends Neurosci 29:225-32. 2006
    ..in the primary rewarding effects of cannabinoids, nicotine, alcohol and opioids, through the release of endocannabinoids in the ventral tegmental area...
  86. ncbi Endocannabinoid-mediated control of synaptic transmission
    Masanobu Kano
    Department of Neurophysiology, The University of Tokyo, Tokyo, Japan
    Physiol Rev 89:309-80. 2009
    The discovery of cannabinoid receptors and subsequent identification of their endogenous ligands (endocannabinoids) in early 1990s have greatly accelerated research on cannabinoid actions in the brain...
  87. ncbi Associative short-term synaptic plasticity mediated by endocannabinoids
    Stephan D Brenowitz
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 45:419-31. 2005
    ..Here, we assess whether endocannabinoids can mediate such plasticity...
  88. pmc A catalytically silent FAAH-1 variant drives anandamide transport in neurons
    Jin Fu
    Department of Pharmacology, University of California, Irvine, Irvine, California, USA
    Nat Neurosci 15:64-9. 2012
    ..The results identify FLAT as a critical molecular component of anandamide transport in neural cells and a potential target for therapeutic drugs...
  89. ncbi Postsynaptic endocannabinoid release is critical to long-term depression in the striatum
    G L Gerdeman
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    Nat Neurosci 5:446-51. 2002
    ..These findings demonstrate a new role for endocannabinoids in the induction of long-term synaptic plasticity in a circuit necessary for habit formation and motor control...
  90. ncbi Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice
    Ying Gao
    Neuroscience Discovery, Pfizer Research, Princeton, New Jersey 08543, and Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 30:2017-24. 2010
    b>Endocannabinoids (eCBs) function as retrograde signaling molecules at synapses throughout the brain, regulate axonal growth and guidance during development, and drive adult neurogenesis...
  91. ncbi Molecular characterization of a peripheral receptor for cannabinoids
    S Munro
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 365:61-5. 1993
    ..Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen...
  92. ncbi Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain
    Madeleine J Oudin
    Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 31:4000-11. 2011
    ..These results describe a novel role for the endocannabinoid system in neuroblast migration in vivo, highlighting its importance in regulating an additional essential step in adult neurogenesis...
  93. ncbi Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain
    Harald S Hansen
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Exp Neurol 224:48-55. 2010
    ....
  94. pmc Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 158:451-61. 2009
    b>Endocannabinoids in tissues controlling energy homeostasis are altered in obesity, thus contributing to metabolic disorders...
  95. ncbi Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt Ingram Cancer Center, and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 277:44877-85. 2002
    Cyclooxygenase-2 (COX-2) action on the endocannabinoids, 2-arachidonylglycerol (2-AG) and anandamide (AEA), generates prostaglandin glycerol esters (PG-G) and ethanolamides (PG-EA), respectively...
  96. ncbi Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors
    T Maejima
    Department of Physiology, Kanazawa University School of Medicine, Takara machi, Kanazawa 920 8640, Japan
    Neuron 31:463-75. 2001
    ..Our data highlight a signaling mechanism whereby activation of postsynaptic mGluR retrogradely influences presynaptic functions via endocannabinoid system...
  97. pmc Expression and function of fatty acid amide hydrolase in prostate cancer
    Michael P Endsley
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Cancer 123:1318-26. 2008
    The hydrolysis of endocannabinoids has profound effects on the function of the endocannabinoid signaling system in the regulation of prostate carcinoma cells...
  98. ncbi Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine
    Andreas Artmann
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1781:200-12. 2008
    b>Endocannabinoids and N-acylethanolamines are lipid mediators regulating a wide range of biological functions including food intake...
  99. pmc A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease
    Justin R Piro
    Neuroscience Research Unit, Pfizer Global Research and Development, Groton, CT 06340, USA
    Cell Rep 1:617-23. 2012
    ..We recently demonstrated that monoacylglycerol lipase (MAGL) hydrolyzes endocannabinoids to generate the primary arachidonic acid pool for neuroinflammatory prostaglandins...
  100. pmc Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice
    Jie Liu
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 9413, USA
    Gastroenterology 142:1218-1228.e1. 2012
    ..We explored the role of hepatic CB(1) in insulin resistance and inhibition of insulin signaling pathways...
  101. pmc Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory
    Piray Atsak
    Department of Neuroscience, Section Anatomy, University Medical Center Groningen, University of Groningen, 9713 AV, Groningen, The Netherlands
    Proc Natl Acad Sci U S A 109:3504-9. 2012
    ..Thus, these findings strongly suggest that the endocannabinoid system plays an intermediary role in regulating rapid glucocorticoid effects on noradrenergic activity in impairing memory retrieval of emotionally arousing experiences...

Research Grants76

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
  3. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..The proposed experiments will determine in animal models the efficacy and mechanisms of action responsible for the antifibrotic effects of ajulemic acid (AJA). ..
  4. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
    ..TRP) pathway plays a pivotal role in pain transmission and the TRPV1 receptor is known to be regulated by endocannabinoids (CB) acting on CB1 receptors which inhibit TRPV1 function...
  5. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..free fatty acids, and bile salts), to neurotransmitters (CGRP and SP), and to paracrine agents (5-HT and endocannabinoids) known to mediate or modulate the peristaltic reflex...
  6. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce S McEwen; Fiscal Year: 2013
    ..Stress effects on structural plasticity and other functions involve interactions among endocannabinoids, excitatory amino acids and glucocorticoids and neuroprotective agents, such as the chaperone, BAG1...
  7. Lipid glyceryl ester homeostasis in macrophages and perturbation by environmental
    Matthew K Ross; Fiscal Year: 2012
    ..Thus, endocannabinoids may have physiological roles in the vasculature that modulate development of atherosclerosis...
  8. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..These studies will provide information that contributes to our understanding of the neural mechanisms of drug addiction and possibly neuropsychiatric and movement disorders, such as schizophrenia and Parkinsonism. ..
  9. Research Center for Pharmacology &Drug Toxicology
    L Jackson Roberts; Fiscal Year: 2013
    ..The proposed research in Project 3 will explore the selective oxygenation of endocannabinoids by cyclooxygenase-2 to form 2-arachidonoylethanolamide and 2-arachidonoylglycerol and their substrate- ..
  10. CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1a
    DANA E contact SELLEY; Fiscal Year: 2010
    ..CB1 receptors also mediate many effects of the lipid-derived endogenous cannabinoids (endocannabinoids)...
  11. Stress and Visceral Hyperalgesia: Epigenetic Mechanisms
    John W Wiley; Fiscal Year: 2012
    ..Therapeutic interventions that target epigenetic mechanisms are touted as a pathway to personalized medicine in the future. ..
  12. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..free fatty acids, and bile salts), to neurotransmitters (CGRP and SP), and to paracrine agents (5-HT and endocannabinoids) known to mediate or modulate the peristaltic reflex...
  13. Endocannabinoid Intracellular Transporters
    Dale G Deutsch; Fiscal Year: 2010
    ..The endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are the major signaling molecules for the cannabinoid ..
  14. Endocannabinoid Discrimination
    Jenny L Wiley; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Anandamide (AEA) and 2-arachidonyl glycerol (2-AG), the two primary endocannabinoids, play an important modulatory role in many crucial CNS processes such as brain reward, appetite regulation, ..
  15. The Biosynthesis of Anandamide
    Dale G Deutsch; Fiscal Year: 2010
    ....
  16. Role of cannabinoid 2 receptors in B lymphocyte function
    Catherine E Patterson; Fiscal Year: 2010
    ..Also, CB2 mRNA expression will be analyzed in stimulated B cell cultures by RT coupled with real time PCR;expression of overlapping transcription factors will be studied by commercially available gene array kits. ..
  17. Unconventional Synaptic Modulation at the Vertebrate Neuromuscular Junction
    Clark A Lindgren; Fiscal Year: 2010
    ..Unconventional neuromodulators, such as nitric oxide, endocannabinoids, and prostaglandins, have been known about for many years;however, their participation in synaptic modulation ..
  18. Role of PGE2 and other eicosanoids in hematopoietic stem cell function
    Louis M Pelus; Fiscal Year: 2013
    ..are physiological lipids that include prostaglandins, prostacyclins, thromboxanes, leukotrienes, and endocannabinoids. Our early studies demonstrated important negative and positive physiological roles forprostaglandin E2 (PGE2)..
  19. Searching for Novel Analgesic and Anti-inflammatory Agents
    Guigen Li; Fiscal Year: 2010
    ..The present NIH-R15 grant will greatly benefit PI's undergraduate and graduate education and help the PI to attract more students into sciences. ..
  20. CNS EFFECTS OF ALCOHOL: CELLULAR NEUROBIOLOGY
    George F Koob; Fiscal Year: 2013
    ..recruitment of a dysregulated central stress system, most notably driven by changes in CRF, glutamate, and endocannabinoids in the extended amygdala (Specific Aim 2)...
  21. Central Endocannabinoid System Dysfunction and Hypertension
    Jeanne L Seagard; Fiscal Year: 2013
    ..In prior studies, evidence was obtained that suggested that endocannabinoids (ECBs), endogenous agonists of neural cannabinoid receptors (CB1Rs), provide a presynaptic mechanism that ..
  22. Kainate receptor signaling in striatal synaptic function and plasticity
    John Marshall; Fiscal Year: 2012
    ..work has determined that, in the striatum, activating kainate receptors facilitates the release of endocannabinoids. This is a novel interaction that has not been previously demonstrated...
  23. Transdermal delivery of 2-Arachidonoyl glycerol (2-AG) for the treatment of arthr
    Audra L Stinchcomb; Fiscal Year: 2012
    ....
  24. Lipidomic profile of endocannabinoids from neuronal cells
    VINCENT JO DAVISSON; Fiscal Year: 2010
    ..The two major endocannabinoids identified in the brain are anandamide (N-arachidonyl- ethanolamide) and 2-AG...
  25. Endocannabinoid modulation of pain-depressed behavior
    LAURA J SIMSELLEY; Fiscal Year: 2013
    ....
  26. (R)-flurbiprofen Substrate-Selective Inhibition of COX-2 and Analog Development
    Daniel Hermanson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Endocannabinoids are endogenously produced fatty acid derivatives that act at the cannabinoid 1 and 2 receptors...
  27. Modulation of Pruritus by Spinal Cannabinoids
    Gregory W Terman; Fiscal Year: 2010
    ..application proposes to begin testing this hypothesis with three specific aims: 1) To verify that spinal endocannabinoids act at spinal CB1 receptors to inhibit itch...
  28. Endocannabinoid signaling in a model of cancer pain
    Virginia S Seybold; Fiscal Year: 2013
    ..Anandamide (AEA) and 2-arachidonoylglycerol (2AG) are two endocannabinoids that are synthesized on demand from membrane phospholipids, and they may play fundamental roles in modulating ..
  29. Endocannabinoid Signaling in Postnatal Ethanol Effects
    BASAVARAJ S BALAPAL; Fiscal Year: 2013
    ..Additionally, the results of the proposed studies may be used by health care professionals in counseling pregnant women on the potential effects of alcohol consumption. ..
  30. Monoacylglycerol Lipase Inhibitors for Treating Opioid Use Disorders
    Aron H Lichtman; Fiscal Year: 2013
    ....
  31. Regulation of Cholinergic Transmission and Theta Rhythms by Endocannabinoids
    DANIEL ALAN NAGODE; Fiscal Year: 2012
    ..Endogenous cannabinoids (endocannabinoids) are retrograde signaling molecules in the central nervous system...
  32. BEHAVIORAL EFFECTS OF CB2 CANNABINOID RECEPTORS (CB2RS)
    Emmanuel S Onaivi; Fiscal Year: 2012
    ..Cannabinoids are the constituents in marijuana and endocannabinoids (eCBs) are the natural endogenous marijuana-like substances found in animals and humans...
  33. Allosteric Modulators of CB1 Cannabinoid Receptor
    GANESHSINGH ARJUNSINGH THAKUR; Fiscal Year: 2010
    ..sub-type-specific and topographically distinct site from the orthosteric pocket, would inhibit the action of endocannabinoids and thus act more selectively to tune CB signaling in a site- and event-specific fashion...
  34. Pope-Presynaptic modulation of anticholinesterase toxicity
    Carey N Pope; Fiscal Year: 2013
    ..b>Endocannabinoids (eCBs, e.g...
  35. Transdermal Cannabidiol Prodrug Delivery
    Audra L Stinchcomb; Fiscal Year: 2011
    ....
  36. Glucocorticoids and endocannabinoids in vagal complex
    Bret N Smith; Fiscal Year: 2013
    ..Possible translational benefits also exist because of the benefit in controlling eCB levels in the vagal system of patients with elevated glucocorticoids. ..
  37. Imaging Brain Cannabinoid Receptors (CB1) in Schizophrenia
    DEEPAK CYRIL D'SOUZA; Fiscal Year: 2013
    ..Since the findings were present in subjects who were unmedicated, the observed changes cannot be attributed to the effects of ongoing antipsychotic medications. ..
  38. CB1 and DA Receptor Deletion by RNAi in Cocaine Self-Administration
    CAROLINE EVELYN BASS; Fiscal Year: 2011
    ..These findings may lead to the development of novel and more effective therapeutic interventions for drug addiction. ..
  39. Endocannabinoid signaling in alcohol induced hepatic steatosis
    LEAH YU LIU; Fiscal Year: 2013
    ..These studies will not only reveal the mechanisms of EC signaling during ALD, but also seek to identify novel therapeutic targets and drugs for the treatment of patients with ALD. ..
  40. Endocannabinoid signaling and aging
    MATTHEW SIMON GILL; Fiscal Year: 2013
    ..enzymes extends lifespan, now suggests that this powerful model organism can be used to define the role of endocannabinoids in lifespan determination...
  41. Presynaptic Release of Endocannabinoids in the Nucleus Accumbens
    Yanhua H Huang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Endocannabinoids (eCBs) mediate one of the most prevalent and complex signaling systems in the central nervous system...
  42. CB1 Receptor-Mediated Tyrosine Phosphorylation of FAK and ERK in Neurons
    George D Dalton; Fiscal Year: 2012
    ....
  43. AMINO ACID TRANSMITTERS AND BRAIN SEXUAL DIFFERENCES
    Margaret M McCarthy; Fiscal Year: 2013
    ..b>Endocannabinoids are lipid derived signaling molecules that ubiquitously regulate synaptic function and are only recently ..
  44. Synaptic plasticity in adolescent cannabis users: relevance to schizophrenia
    Subroto Ghose; Fiscal Year: 2013
    ....
  45. CaMKII, endocannabinoids, synaptic plasticity and motor function
    Roger J Colbran; Fiscal Year: 2013
    ..Test the hypothesis that CaMKII modulates eCB-dependent motor activity. We will evaluate motor activity and coordination under basal conditions and following pharmacological modulation of 2-AG metabolism in WT, T286A-KI and eAC3I mice. ..
  46. Molecular characterization of endocannabinoid degradative enzymes
    JACQUELINE LORAYNE BLANKMAN; Fiscal Year: 2012
    ..The endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) are the endogenous ligands of CB1 and are thought to ..
  47. Endocannabinoid and Cholecystokinin Interactions Mediating Extinction Learning
    Mallory Bowers; Fiscal Year: 2013
    ..Studies of cannabinoid receptor (Cb1) knockout mice suggest that the retrograde transmitters known as the endocannabinoids are critical for extinction of conditioned fear1...
  48. Role of Endocannabinoids in Levodopa-Induced Dyskinesias
    Andrea Giuffrida; Fiscal Year: 2012
    ..The study will identify new and more effective therapeutic strategies for the treatment of levodopa-associated motor complications. ..
  49. Functional Analysis of Cyclooxygenase-2
    Lawrence J Marnett; Fiscal Year: 2013
    ..opportunities to develop chemical probes to investigate the in vivo importance of COX-2 oxygenation of endocannabinoids and may explain the reported anti-inflammatory and cancer preventive activities of (R)-profens...
  50. Endocannabinoid Signaling During Early Pregnancy
    Sudhansu K Dey; Fiscal Year: 2012
    ..N-arachidonoylethanolamine (anandamide) and 2-arachidonoyglycerol (2-AG) function as endogenous ligands (endocannabinoids) for cannabinoid receptors (CB1 and CB2). CB1 and CB2 are G protein-coupled receptors...
  51. Chronic Ethanol's Effects on Endocannabinoid Modulation of Neocrotical Up-states
    Matthew J Pava; Fiscal Year: 2010
    ..b>Endocannabinoids (eCB) are a class of neuromodulators that regulate PFC function, and the eCB system is itself perturbed by ..
  52. Mechanistic studies of 2-AG inactivation inhibitors as antidepressants
    Qing Song Liu; Fiscal Year: 2013
    ....
  53. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    Virginia M Pickel; Fiscal Year: 2013
    ..Metabotropic glutamate (mGlu) receptors and endocannabinoids, active at the cannabinoid type-1 (CB1) receptor, are increasingly implicated in the synaptic plasticity ..
  54. Endocannabinoid Inactivation:Plasma Membrane Uptake and Cellular Trafficking
    Dale G Deutsch; Fiscal Year: 2012
    The endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are the major signaling molecules for the cannabinoid receptors CB1 and CB2...
  55. Ethanol Remodeling of Striatal Microcircuits
    BRIAN NEIL MATHUR; Fiscal Year: 2013
    ..The data derived from this study should provide novel therapeutic strategies targeting alcohol dependence. ..
  56. CELLULAR SUBSTRATES OF CEREBELLAR INFORMATION STORAGE
    David J Linden; Fiscal Year: 2013
    ..To extend analysis of meta-plastic effects, we shall assess the interaction of LTD(mGluR1) with short-term retrograde modulation of glutamate release that uses mGluR1-driven endocannabinoid signaling. ..
  57. Structure-Function Studies of Endocannabinoid Biosynthetic Enzymes
    JOSE OLUCHA - ALVAREZ; Fiscal Year: 2013
    ..Ray Stevens'group. The knowledge on DAG lipases obtained through the work proposed in this project has the potential to become an important tool for the rational design of inhibitors against these key therapeutic targets. ..
  58. Endogenous Cannabinoids and NGF Signaling in Pain Associated with Cystitis
    DALE EDMOND BJORLING; Fiscal Year: 2013
    ..Endogenous cannabinoids (endocannabinoids) function to limit inflammatory pain, but very little is known about their function in the bladder...
  59. Qualification of Novel Immune Markers in Human Serum of Patients with MS
    Michelle Sexton; Fiscal Year: 2010
    ..The primary aims of this research are: Aim 1: To measure endocannabinoids (eCBs) in human serum to determine if there is a difference between healthy subjects and patients with ..
  60. Presynaptic Forms of Long-Term Plasticity in the CNS
    Pablo E Castillo; Fiscal Year: 2013
    ..new type of use-dependent synaptic plasticity that requires retrograde signaling by endogenous cannabinoids (endocannabinoids) has been identified in several brain structures...
  61. Mechanisms of Intercelllar Communication
    VYTAUTAS K VERSELIS; Fiscal Year: 2013
    ..Trainees are encouraged to take full advantage of the multiplicity of scientific opportunities in the College as a whole. RELEVANCE (See instructions): ..
  62. Cannabinoid mobilization in neurons (R15DA021683)
    Masako Isokawa; Fiscal Year: 2013
    ..Natural molecules that activate CB1R are endocannabinoids (eCBs)...
  63. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..There are endogenous cannabinoids (or endocannabinoids) such as anandamide and 2-arachidonyl glycerol...
  64. The role of cannabinoid signaling in the nematode Caenorhabditis elegans
    MATTHEW SIMON GILL; Fiscal Year: 2010
    ..In this respect, I have discovered that the worm contains several endocannabinoids that are structurally related to the CB receptor ligands in mammals...
  65. Inhibition of Endocannabinoid Biosynthesis via Diacylglycerol Lipase
    RICHARD DUCLOS; Fiscal Year: 2009
    ..This downregulation of endocannabinoid signaling may have a benefical effect on obesity, recovery from addiction, and movement disorder symptoms from the resulting changes in cell communication pathways. ..
  66. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2003
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  67. ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACH
    Andrea Hohmann; Fiscal Year: 2007
    ..Successful validation of our technological approach and hypotheses may facilitate development of endocannabinoid-based pharmacological and gene therapies for pain. [unreadable] [unreadable] [unreadable]..
  68. Control of Breast Cancer by the Endocannabinoid System
    Sean McAllister; Fiscal Year: 2009
    ..This research may also elucidate novel mechanisms related to the anticancer activity of cannabinoids, and will serve to develop the career of the candidate in the field of cancer biology. ..
  69. Stress regulation of the endocannabinoid system: Effects on synaptic physiology
    Christian Reich; Fiscal Year: 2009
    ..b>Endocannabinoids, analogs of 9-THC, are neuromodulators implicated in regulating stress and anxiety...
  70. Role of monoacylglycerol lipase in coordinating diverse lipid signaling pathways
    DANIEL KOJI NOMURA; Fiscal Year: 2010
    ..In brain, MAGL controls endocannabinoids and prostaglandins- both important in neuroinflammation...
  71. REPRESSION OF T CELL ACTIVATION BY ENDOCANNABINOIDS
    Norbert Kaminski; Fiscal Year: 2003
    ..endogenous eicosinoid-like cannabinoids; and (b) to elucidate the signal transduction pathways by which these endocannabinoids disrupt T-cell activation...
  72. Endocannabinoid Modulation of Pruritus
    JOEL SCHLOSBURG; Fiscal Year: 2009
    ..and enzyme inhibitors) to investigate the receptor mechanisms, anatomical loci, and physiologic response of endocannabinoids in management of itch...
  73. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  74. NOVEL ENDOGENOUS CARDIOVASCULAR REGULATORS
    Edward Ishac; Fiscal Year: 2000
    ..The findings of the proposed research will significantly expand our understanding of paracrine mechanisms involved in the control of vascular tone. ..
  75. Cannabinoid modulation of epileptiform activity in mice
    Bret Smith; Fiscal Year: 2006
    ..Understanding these effects may promote more effective treatment strategies designed specifically for TLE patients, whose brains have undergone a degree of synaptic reorganization. [unreadable] [unreadable]..
  76. In-vivo Modulation of Synapses by Endocannabinoids
    Alberto Pereda; Fiscal Year: 2009
    The long-term objective of the proposed research is to study the modulatory actions of endocannabinoids on synaptic transmission in the CNS...