anabolic agents

Summary

Summary: These compounds stimulate anabolism and inhibit catabolism. They stimulate the development of muscle mass, strength, and power.

Top Publications

  1. ncbi Effects of androgenic-anabolic steroids in athletes
    Fred Hartgens
    Department of Surgery, Outpatient Clinic Sports Medicine, University Hospital Maastricht, and Sports Medicine Center Maastricht, Maastricht, The Netherlands
    Sports Med 34:513-54. 2004
  2. ncbi Experiences of anabolic steroid use: in-depth interviews with men and women body builders
    Sarah Grogan
    Department of Psychiatry, Staffordshire University, Stoke on Trent, UK
    J Health Psychol 11:845-56. 2006
  3. ncbi A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: the role of aryl hydrocarbon receptor as a mediator of osteogenic action
    Kunal Sharan
    Division of Endocrinology, CSIR Central Drug Research Institute, Lucknow, India
    J Bone Miner Res 26:2096-111. 2011
  4. pmc Anabolic agents and bone quality
    Tarek Sibai
    Department of Orthopaedic Surgery, Boston University Medical Center, 720 Harrison Avenue, Suite 808, Boston, MA 02118, USA
    Clin Orthop Relat Res 469:2215-24. 2011
  5. ncbi Clinical review 138: Anabolic-androgenic steroid therapy in the treatment of chronic diseases
    S Basaria
    The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 86:5108-17. 2001
  6. ncbi Skeletal muscle morphology in power-lifters with and without anabolic steroids
    Anders Eriksson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, 901 87 Umea, Sweden
    Histochem Cell Biol 124:167-75. 2005
  7. ncbi Anabolic agents: a new chapter in the management of osteoporosis
    Abdul Wahab Khan
    Faculty of Science, University of Ottawa, Ottawa ON
    J Obstet Gynaecol Can 28:136-41. 2006
  8. ncbi A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial
    Eva C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Chest 124:1733-42. 2003
  9. pmc Anabolic steroid abuse among teenage girls: an illusory problem?
    Gen Kanayama
    Biological Psychiatry Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 88:156-62. 2007
  10. ncbi Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity
    Joshua F Yarrow
    Geriatric Research, Education and Clinical Center, VA Medical Center, Gainesville, FL 32608, United States
    Steroids 75:377-89. 2010

Research Grants

  1. Novel Drug VS-105 for Treatment of Osteoporosis
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
  2. Eicosapentaenoic acid and protein modulation to induce anabolism in COPD
    MARIELLE PKJ ENGELEN; Fiscal Year: 2012
  3. Synthesis of bone-selective osteogenic oxysterols
    Frank Stappenbeck; Fiscal Year: 2013
  4. FGF SIGNALING IN SKELETAL DEVELOPMENT, HOMEOSTASIS AND AGING
    David M Ornitz; Fiscal Year: 2013
  5. Genetics of Osteoblast Differentiation
    Matthew Aaron Hibbs; Fiscal Year: 2012
  6. A megakaryocyte/PGE2/osteoblast triad in the normal and aged niche
    Louis M Pelus; Fiscal Year: 2013
  7. Extrarenal Functions of Polycystin-1
    L Darryl Quarles; Fiscal Year: 2013
  8. Mechanisms of Age-Related Skeletal Resistance to BMP-7 and IGF-I
    John C Lee; Fiscal Year: 2012
  9. BONE TARGETED DELIVERY OF ANABOLIC AGENTS
    JINDRICH H KOPECEK; Fiscal Year: 2011
  10. Mechanobiological Mechanism for Inflammaory Bone Loss
    Francis Young In Lee; Fiscal Year: 2013

Detail Information

Publications199 found, 100 shown here

  1. ncbi Effects of androgenic-anabolic steroids in athletes
    Fred Hartgens
    Department of Surgery, Outpatient Clinic Sports Medicine, University Hospital Maastricht, and Sports Medicine Center Maastricht, Maastricht, The Netherlands
    Sports Med 34:513-54. 2004
    ..AAS-induced increment of muscle tissue can be attributed to hypertrophy and the formation of new muscle fibres, in which key roles are played by satellite cell number and ultrastructure, androgen receptors and myonuclei...
  2. ncbi Experiences of anabolic steroid use: in-depth interviews with men and women body builders
    Sarah Grogan
    Department of Psychiatry, Staffordshire University, Stoke on Trent, UK
    J Health Psychol 11:845-56. 2006
    ..Social support, especially from within the body building community, was an important motivator. It is concluded that intervention programmes need the support of the body building community in order to be effective...
  3. ncbi A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: the role of aryl hydrocarbon receptor as a mediator of osteogenic action
    Kunal Sharan
    Division of Endocrinology, CSIR Central Drug Research Institute, Lucknow, India
    J Bone Miner Res 26:2096-111. 2011
    ..Based on these preclinical data, clinical evaluation of GTDF as a potential bone anabolic agent is warranted...
  4. pmc Anabolic agents and bone quality
    Tarek Sibai
    Department of Orthopaedic Surgery, Boston University Medical Center, 720 Harrison Avenue, Suite 808, Boston, MA 02118, USA
    Clin Orthop Relat Res 469:2215-24. 2011
    The definition of bone quality is evolving particularly from the perspective of anabolic agents that can enhance not only bone mineral density but also bone microarchitecture, composition, morphology, amount of microdamage, and ..
  5. ncbi Clinical review 138: Anabolic-androgenic steroid therapy in the treatment of chronic diseases
    S Basaria
    The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 86:5108-17. 2001
    ....
  6. ncbi Skeletal muscle morphology in power-lifters with and without anabolic steroids
    Anders Eriksson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, 901 87 Umea, Sweden
    Histochem Cell Biol 124:167-75. 2005
    ..The results of AS on VL morphology in this study were similar to previously reported short-term effects of AS on VL. The initial effects from AS appear to be maintained for several years...
  7. ncbi Anabolic agents: a new chapter in the management of osteoporosis
    Abdul Wahab Khan
    Faculty of Science, University of Ottawa, Ottawa ON
    J Obstet Gynaecol Can 28:136-41. 2006
    ..Anabolic therapies should complement the antiresorptive treatments currently available for use in women with postmenopausal osteoporosis...
  8. ncbi A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial
    Eva C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Chest 124:1733-42. 2003
    ..Anabolic steroids could be an additional mode of intervention to improve outcome of pulmonary rehabilitation by increasing physiologic functioning, possibly mediated by increasing erythropoietic function...
  9. pmc Anabolic steroid abuse among teenage girls: an illusory problem?
    Gen Kanayama
    Biological Psychiatry Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 88:156-62. 2007
    ..We questioned whether AAS use among teenage girls was as widespread as claimed...
  10. ncbi Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity
    Joshua F Yarrow
    Geriatric Research, Education and Clinical Center, VA Medical Center, Gainesville, FL 32608, United States
    Steroids 75:377-89. 2010
    ....
  11. ncbi Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases
    Tiia Kuuranne
    Division of Pharmaceutical Chemistry, University of Helsinki, Finland
    Drug Metab Dispos 31:1117-24. 2003
    ..Furthermore, the high activity of UGT1A8 and 1A10 toward some of the substrates indicates that extrahepatic enzymes might play a role in the metabolism of anabolic androgenic steroids...
  12. pmc Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors
    Daniel W D West
    Exercise Metabolism Research Group, Dept of Kinesiology, McMaster Univ, Hamilton, ON L8S4K1 Canada
    J Appl Physiol (1985) 108:60-7. 2010
    ..We conclude that exposure of loaded muscle to acute exercise-induced elevations in endogenous anabolic hormones enhances neither muscle hypertrophy nor strength with resistance training in young men...
  13. ncbi Doping in fitness sports: estimated number of unreported cases and individual probability of doping
    Perikles Simon
    University of Tuebingen, Department of Sports Medicine, General Internal Medicine V, Tuebingen, Germany
    Addiction 101:1640-4. 2006
    ..In this study we applied an alternative interview technique to assess more accurately unreported cases of doping in fitness centres...
  14. ncbi A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids
    N T Shahidi
    Department of Pediatric Hematology and Oncology, University of Wisconsin, Madison 53792-4672, USA
    Clin Ther 23:1355-90. 2001
    ....
  15. ncbi Adolescent anabolic steroid use, gender, physical activity, and other problem behaviors*
    Kathleen E Miller
    Research Institute on Addictions, University at Buffalo, Buffalo, NY 14203, USA
    Subst Use Misuse 40:1637-57. 2005
    ..Interventions to prevent steroid use should not be limited to male participants in organized sports programs, but should also target adolescents identified as at risk for other problem behaviors...
  16. ncbi Anabolic steroid use in weightlifters and bodybuilders: an internet survey of drug utilization
    Paul J Perry
    Department of Psychiatry, College of Medicine, and the College of Pharmacy, University of Iowa, Iowa City, IA 52242 1112, USA
    Clin J Sport Med 15:326-30. 2005
    ..Prior reports of anabolic steroid use suggest polypharmacy and high doses of injectable agents...
  17. ncbi Anabolics in osteoporosis: the emerging therapeutic tool
    R Trivedi
    Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    Curr Mol Med 10:14-28. 2010
    ..The anabolic agents currently in clinical use are reviewed...
  18. ncbi Current concepts in anabolic-androgenic steroids
    Nick A Evans
    UCLA Orthopaedic Hospital, Los Angeles, California, USA
    Am J Sports Med 32:534-42. 2004
    ..In the wake of important scientific advances during the past decade, the positive and negative effects of AAS warrant reevaluation. Guidelines for the clinical evaluation of AAS users will be presented for sports medicine practitioners...
  19. ncbi Misuse of androgenic-anabolic steroids and human deltoid muscle fibers: differences between polydrug regimens and single drug administration
    F Hartgens
    Netherlands Centre for Doping Affairs, Capelle aan den IJssel, The Netherlands
    Eur J Appl Physiol 86:233-9. 2002
    ....
  20. pmc Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men
    Daniel W D West
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    J Physiol 587:5239-47. 2009
    ..Local mechanisms are likely to be of predominant importance for the post-exercise increase in MPS...
  21. ncbi The anti-doping hot-line, a means to capture the abuse of doping agents in the Swedish society and a new service function in clinical pharmacology
    Ann Charlotte Eklöf
    Department of Clinical Pharmacology, Huddinge University Hospital, 14185 Stockholm, Sweden
    Eur J Clin Pharmacol 59:571-7. 2003
    ..Abuse of doping agents appears to be a new public health problem that needs detection, medical care and prevention...
  22. ncbi Hepatocyte nuclear phenotype: the cross-talk between anabolic androgenic steroids and exercise in transgenic mice
    Karina Fontana
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil
    Histol Histopathol 23:1367-77. 2008
    ..In this study, the image analysis permitted the monitoring of the nuclear response to mesterolone and physical exercise action in liver cells, the molecular mechanism of which is in prospect...
  23. ncbi Drugs in sport - the role of the physician
    R T Dawson
    Drugs In Sport Clinic and User s Support DISCUS, Adderstone House, Dene Road, Rowlands Gill, Tyne and Wear, NE39 1DU, UK
    J Endocrinol 170:55-61. 2001
    ..For the elite athlete, what price a gold medal that is tarnished by deceit? Its value then can only lie with the sponsors and politicians, for they can no longer claim to be sportsmen, only entertainers...
  24. pmc Effect of oral anabolic steroid on muscle strength and muscle growth in hemodialysis patients
    Ouppatham Supasyndh
    Division of Nephrology, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand
    Clin J Am Soc Nephrol 8:271-9. 2013
    ..Sarcopenia is common in hemodialysis patients. This study examined whether the anabolic steroid oxymetholone improves muscle mass and handgrip strength in hemodialysis patients and possible mechanisms that might engender such changes...
  25. ncbi Anabolic effects of Peniel 2000, a peptide that regulates TGF-β1 signaling on intervertebral disc degeneration
    Young Joon Kwon
    Department of Drug Development, Technology Research Institute, Ensoltek Co, Ltd, Daejeon, Korea
    Spine (Phila Pa 1976) 38:E49-58. 2013
    ..An in vitro study with bovine intervertebral disc (IVD) cells and an in vivo study with a rabbit disc degeneration model on the extracellular matrix metabolism by a biglycan-derived peptide (Peniel 2000; P2K)...
  26. ncbi Past anabolic-androgenic steroid use among men admitted for substance abuse treatment: an underrecognized problem?
    Gen Kanayama
    Alcohol and Drug Abuse Research Center, McLean Hospital, Belmont, Mass 02478, USA
    J Clin Psychiatry 64:156-60. 2003
    ..At present, however, little is known about prior AAS use among men entering inpatient substance abuse treatment...
  27. ncbi Effects of anabolic steroids on the muscle cells of strength-trained athletes
    F Kadi
    Department of Integrative Medical Biology, Umea University, Sweden
    Med Sci Sports Exerc 31:1528-34. 1999
    ..Athletes who use anabolic steroids get larger and stronger muscles. How this is reflected at the level of the muscle fibers has not yet been established and was the topic of this investigation...
  28. ncbi Psychiatric and medical effects of anabolic-androgenic steroid use in women
    A J Gruber
    Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Psychother Psychosom 69:19-26. 2000
    ..Although numerous studies have documented the psychiatric and physiological effects of anabolic-androgenic steroids (AAS) in males, virtually no studies have investigated the effects of illicit AAS use in women...
  29. ncbi Discovery of coumarin-dihydropyridine hybrids as bone anabolic agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute CSIR CDRI, Lucknow 226001, India
    J Med Chem 56:109-22. 2013
    ....
  30. ncbi Anabolic androgenic steroids produce dose-dependant increase in left ventricular mass in power atheletes, and this effect is potentiated by concomitant use of growth hormone
    T A M Karila
    Laboratory of Substance Abuse, National Public Health Institute, Helsinki, Finland
    Int J Sports Med 24:337-43. 2003
    ..Our findings suggest that AASs and GH have a direct effect on the myocardium...
  31. ncbi Differential effects of nandrolone decanoate in fast and slow rat skeletal muscles
    W H Joumaa
    General Physiology Laboratory, CNRS E P 1593, Faculty of Sciences and Technology, University of Nantes, 44322 Nantes, France
    Med Sci Sports Exerc 33:397-403. 2001
    ..We studied the effects of high doses of an anabolic-androgenic steroid, exercise training, and a combination of steroid and training on mammalian fast- and slow-twitch skeletal muscles at the cellular level...
  32. ncbi RNA-sequencing as useful screening tool in the combat against the misuse of anabolic agents
    Irmgard Riedmaier
    Physiology Weihenstephan, and ZIEL Research Center for Nutrition and Food Sciences, Technical University Munich, Weihenstephaner Berg 3, 85354 Freising, Germany
    Anal Chem 84:6863-8. 2012
    ..The analysis of physiological changes caused by the use of anabolic agents on the molecular level, for example, by quantifying gene expression response, is a new approach to develop ..
  33. ncbi Targeting the osteoblast: approved and experimental anabolic agents for the treatment of osteoporosis
    Konstantinos A Toulis
    Department of Endocrinology and Metabolism, 424 General Military Hospital, Thessaloniki, Greece
    Hormones (Athens) 10:174-95. 2011
    ..Safety and tissue specificity are the prerequisites in the development of a novel treatment, especially when addressing a chronic condition such as osteoporosis...
  34. ncbi Sports-related issues and biochemistry of natural and synthetic anabolic substances
    Maria K Parr
    Institute of Biochemistry, German Sport University Cologne DSHS, Cologne, Germany
    Endocrinol Metab Clin North Am 39:45-57, viii. 2010
    ..These products represent a major problem to doping control. Recently, clinical trials with selective androgen receptor modulators have been started...
  35. ncbi Biochemistry and physiology of anabolic hormones used for improvement of meat production
    H H Meyer
    Institute of Physiology, Technical University Munich Weihenstephan, Freising Weihenstephan, Germany
    APMIS 109:1-8. 2001
    ..Growth hormone and beta2-agonists use independent pathways for growth promotion not related to steroid biochemistry...
  36. ncbi Use of doping agents, particularly anabolic steroids, in sports and society
    Folke Sjöqvist
    Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden
    Lancet 371:1872-82. 2008
    ..The prevention of misuse of doping agents should include random doping analyses, medical follow-ups, pedagogic interventions, tougher legislation against possession of AAS, and longer disqualifications of athletes who use AAS...
  37. ncbi Androgens and the control of skeletal muscle protein synthesis
    M Sheffield-Moore
    Department of Surgery, University of Texas Medical Branch, Galveston 77550, USA
    Ann Med 32:181-6. 2000
    ..In this brief review, newly discovered information and emerging theories relating to the direct, indirect, priming and antiglucocorticoid action of androgens on skeletal muscle will be presented...
  38. ncbi Modification of mRNA expression after treatment with anabolic agents and the usefulness for gene expression-biomarkers
    Martina Reiter
    Physiology Weihenstephan, Technische Universitat Munchen, Weihenstephaner Berg 3, 85354 Freising, Germany
    Anal Chim Acta 586:73-81. 2007
    ..With the investigation of the regulation and possible function of anabolic sex steroids via gene expression, a preparatory work for the development of an expression pattern for drug screening was made...
  39. pmc Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging
    Micah J Drummond
    Department of Physical Therapy, Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
    J Appl Physiol (1985) 104:1452-61. 2008
    ..Notwithstanding, the combination of resistance exercise and EAA ingestion should be a useful strategy to combat sarcopenia...
  40. ncbi Abuse of anabolic androgenic steroids and related substances in sport and exercise
    Michael S Bahrke
    Human Kinetics, 1607 North Market Street, Champaign, Illinois 61825 5076, USA
    Curr Opin Pharmacol 4:614-20. 2004
    ..However, research demonstrates that DHEA supplementation does not increase serum testosterone concentrations or increase strength in men, and may acutely increase testosterone levels in women, thus producing a virilizing effect...
  41. ncbi Improving muscle mass: response of muscle metabolism to exercise, nutrition and anabolic agents
    Kevin D Tipton
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Essays Biochem 44:85-98. 2008
    ..Results from acute metabolic studies provide useful information for estimation of the efficacy of anabolic agents.
  42. pmc Long-term psychiatric and medical consequences of anabolic-androgenic steroid abuse: a looming public health concern?
    Gen Kanayama
    Biological Psychiatry Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, United States
    Drug Alcohol Depend 98:1-12. 2008
    ..The senior members of this population are now entering middle age; they represent the leading wave of a new type of aging former substance abusers, with specific medical and psychiatric risks...
  43. ncbi Evaluation of a health promotion programme to prevent the misuse of androgenic anabolic steroids among Swedish adolescents
    Sverker Nilsson
    Department of Primary Health Care, Varberg, Sweden
    Health Promot Int 19:61-7. 2004
    ..This study indicates that drug abuse among adolescents can be decreased by health promotion activities, such as group discussions. Controlled studies are needed before the results of this appearance programme can be generalized...
  44. ncbi Association between narcotic use and anabolic-androgenic steroid use among American adolescents
    Bryan E Denham
    Department of Communication Studies, Clemson University, Clemson, South Carolina 29634, USA
    Subst Use Misuse 44:2043-61. 2009
    ..Implications for health practitioners and recommendations for future research are offered. The study's limitations are noted...
  45. ncbi Favorable final height outcome in girls with Ullrich-Turner syndrome treated with low-dose growth hormone together with oxandrolone despite starting treatment after 10 years of age
    N Stahnke
    University Hospital, Department of Pediatrics, Hamburg, Germany
    J Pediatr Endocrinol Metab 15:129-38. 2002
    ..Moderate doses of GH plus Ox and late induction of puberty definitely improved final height even in patients with UTS treated relatively late...
  46. pmc The fate of trenbolone acetate and melengestrol acetate after application as growth promoters in cattle: environmental studies
    B Schiffer
    Institute of Physiology, TU München Weihenstephan, Freising Weihenstephan, Germany
    Environ Health Perspect 109:1145-51. 2001
    ..The results show that these substances should be investigated further concerning their potential endocrine-disrupting activity in agricultural ecosystems...
  47. ncbi Over-the-counter drug use in gymnasiums: an underrecognized substance abuse problem?
    G Kanayama
    Biological Psychiatry Laboratory, McLean Hospital, Belmont, Mass, and Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Psychother Psychosom 70:137-40. 2001
    ..We sought to estimate the prevalence of these forms of drug use in American gymnasiums...
  48. ncbi A double-blind, placebo-controlled trial of testosterone therapy for HIV-positive men with hypogonadal symptoms
    J G Rabkin
    New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    Arch Gen Psychiatry 57:141-7; discussion 155-6. 2000
    ..The goal was to evaluate the efficacy of testosterone in alleviation of hypogonadal symptoms (diminished libido, depressed mood, low energy, and depleted muscle mass) in men with symptomatic human immunodeficiency virus illness...
  49. ncbi Medicine and science in the fight against doping in sport
    D H Catlin
    Anti Doping Research Institute, 3873 Grand View Blvd, Los Angeles, CA 90066, USA
    J Intern Med 264:99-114. 2008
    ....
  50. ncbi Anabolic-androgenic steroid use among young male and female athletes: is the game to blame?
    P A Harmer
    Department of Exercise Science, Willamette University, Salem, OR 97301, USA
    Br J Sports Med 44:26-31. 2010
    ....
  51. ncbi Anabolic steroids: a review for the clinician
    Eric C Kutscher
    Western Missouri Mental Health Center, Kansas City, Missouri 64108, USA
    Sports Med 32:285-96. 2002
    ..This review will address the common anabolic steroid misconceptions held by many of today's athletes by providing an evaluation of the scientific literature related to AS in athletic performance...
  52. ncbi Acute kidney injury due to anabolic steroid and vitamin supplement abuse: report of two cases and a literature review
    Elizabeth F Daher
    Division of Nephrology, Hospital Geral de Fortaleza, Secretaria da Saúde do Estado do Ceará, Fortaleza, CE, Brazil
    Int Urol Nephrol 41:717-23. 2009
    ..Acute kidney injury (AKI) is not frequently described. The purpose of this study is to report two cases of AKI associated with anabolic steroid and vitamin supplement abuse...
  53. ncbi Prolonged intrahepatic cholestasis and renal failure secondary to anabolic androgenic steroid-enriched dietary supplements
    Prashant V Krishnan
    Division of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI, 48202, USA
    J Clin Gastroenterol 43:672-5. 2009
    ..Recognition of this entity could obviate the need for invasive diagnostic testing and hospitalization and facilitate diagnosis and appropriate counseling...
  54. pmc Anabolic-androgenic steroid dependence? Insights from animals and humans
    Ruth I Wood
    Department of Cell and Neurobiology, Keck School of Medicine of the University of Southern California, 1333 San Pablo Street, BMT 401, Los Angeles, CA 90033, USA
    Front Neuroendocrinol 29:490-506. 2008
    ..In humans, AAS abuse is associated with prescription opioid use. In animals, AAS overdose produces symptoms resembling opioid overdose, and AAS modify the activity of the endogenous opioid system...
  55. ncbi Acute myocardial infarction in a young man using anabolic steroids
    Mariusz Wysoczanski
    Department of Internal Medicine Beth Israel Medical Center, New York, NY 10003, USA
    Angiology 59:376-8. 2008
    ..We report a case of MI in a young 31-year-old bodybuilder. Because of the serious cardiovascular complications of anabolic steroids, physicians should be aware of their abuse and consequences...
  56. ncbi [Severe cholestasis with kidney failure from anabolic steroids in a body builder]
    W Habscheid
    Medizinische Klinik, Paracelsus Krankenhaus Ruit, Esslingen
    Dtsch Med Wochenschr 124:1029-32. 1999
    ..Physical examination was unremarkable except for yellow discoloration of the skin and sclerae...
  57. ncbi Sports drug testing--an analyst's perspective
    Graham J Trout
    Australian Sports Drug Testing Laboratory, Australian Government Analytical Laboratories, Sydney, Australia
    Chem Soc Rev 33:1-13. 2004
    ..The contest between those who wish to cheat and those who wish to maintain fair play in sport is an ongoing one...
  58. ncbi [Severe nephrotic syndrome in a young man taking anabolic steroid and creatine long term]
    Tamás Révai
    Szent János Kórház, II Belgyógyászat, Nefrologia
    Orv Hetil 144:2425-7. 2003
    ..They also call attention to the role of the continuously consumed creatine in the renal failure...
  59. ncbi The effect of high school sports participation on the use of performance-enhancing substances in young adulthood
    Tonya L Dodge
    Department of Psychology, The George Washington University, Washington, DC 20052, USA
    J Adolesc Health 39:367-73. 2006
    ..Additionally, the relationship between the use of AS and legal dietary supplements was explored...
  60. ncbi Hair analysis of anabolic steroids in connection with doping control-results from horse samples
    P Anielski
    Institute of Doping Analysis and Sports Biochemistry, Dresdner Strasse 12, D 01731 Kreischa, Germany
    J Mass Spectrom 43:1001-8. 2008
    ..Trimethylsilyl (TMS) and tert-butyl dimethylsilyl derivatives were detected by gas chromatography-high-resolution mass spectrometry (GC-HRMS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)...
  61. pmc The development of multiple drug use among anabolic-androgenic steroid users: six subjective case reports
    Kurt Skarberg
    School of Health and Medical Sciences, Psychiatric Research Centre, Orebro University, Orebro, Sweden
    Subst Abuse Treat Prev Policy 3:24. 2008
    ..The aim of this study was to improve understanding of the development of multiple drug use in patients seeking treatment at an addiction clinic for AAS-related problems...
  62. ncbi Anabolic-androgenic steroid abuse and performance-enhancing drugs among adolescents
    M S Bahrke
    Academic Books Division, Human Kinetics Publishers, Champaign, Illinois, USA
    Child Adolesc Psychiatr Clin N Am 7:821-38. 1998
    ..Assessment of anabolic steroid abuse includes physical and mental status and laboratory examinations. Steroid cessation, supportive therapy, and adjunctive pharmacotherapies are all employed in treating steroid abuse and dependence...
  63. ncbi Anabolic androgenic steroids: a survey of 500 users
    Andrew B Parkinson
    Department of Orthopaedic Surgery, Harbor UCLA Medical Center, Torrance, CA 90007, USA
    Med Sci Sports Exerc 38:644-51. 2006
    ..The purpose of this study is to identify current trends in the drug-taking habits of AAS users...
  64. ncbi Increased premature mortality of competitive powerlifters suspected to have used anabolic agents
    M Pärssinen
    National Public Health Institute, Laboratory of Substance Abuse, Helsinki, Finland
    Int J Sports Med 21:225-7. 2000
    ....
  65. pmc Pharmacology of anabolic steroids
    A T Kicman
    King s College London, Drug Control Centre, Department of Forensic Science and Drug Monitoring, London, UK
    Br J Pharmacol 154:502-21. 2008
    ....
  66. ncbi Identification of potential gene expression biomarkers for the surveillance of anabolic agents in bovine blood cells
    Irmgard Riedmaier
    Physiology Weihenstephan, Technische Universitaet Muenchen, Weihenstephaner Berg 3, 85354 Freising, Germany
    Anal Chim Acta 638:106-13. 2009
    ..Therefore, new monitoring systems are needed to overcome the misuse of anabolic agents in meat production...
  67. ncbi Anabolic steroids: what should the emergency physician know?
    James T Brown
    OSF Saint Francis Medical Center, 530 N E Glen Oak, Peoria, IL 61637, USA
    Emerg Med Clin North Am 23:815-26, ix-x. 2005
    ..As research continues, the emergency physician may find uses for androgens within the emergency department...
  68. ncbi The use of anabolic agents in HIV disease
    G Newshan
    Yonkers General Hospital, Yonkers, New York, USA
    Int J STD AIDS 12:141-4. 2001
    ..This article will review commonly prescribed anabolic agents, discuss potential side effects and contraindications.
  69. ncbi Anabolic ergogenic substance users in fitness-sports: a distinct group supported by the health care system
    Heiko Striegel
    Department Sports Medicine, University of Tuebingen, Silchertrasse 5, 72076 Tuebingen, Germany
    Drug Alcohol Depend 81:11-9. 2006
    ..Nevertheless, it is subject to debate whether ergogenic substance users exhibit similar features as multiple substance users or whether they constitute a discrete group...
  70. ncbi Anabolic steroid users' attitudes towards physicians
    Harrison G Pope
    Biological Psychiatry Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Addiction 99:1189-94. 2004
    ..To assess anabolic-androgenic steroid (AAS) users' trust in the knowledge and advice of physicians...
  71. ncbi Anabolic agents and the bone morphogenetic protein pathway
    I R Garrett
    OsteoScreen, San Antonio, Texas 78229, USA
    Curr Top Dev Biol 78:127-71. 2007
    ..Consequently, the discovery of low cost orally available bone anabolic agents is critical for the future treatment of bone loss conditions...
  72. ncbi Consequences of use of anabolic androgenic steroids
    Marcel J Casavant
    Department of Pediatrics, The Ohio State University College of Medicine, 370 West 9th Ave, Columbus, OH 43210, USA
    Pediatr Clin North Am 54:677-90, x. 2007
    ....
  73. ncbi Medical complications of anabolic steroids
    Alexander A Feller
    Miriam Hospital, USA
    Med Health R I 85:338-40. 2002
  74. ncbi In vitro and in vivo effects of 17beta-trenbolone: a feedlot effluent contaminant
    Vickie S Wilson
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 72, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 70:202-11. 2002
    ..In summary, TB is a potent environmental androgen both in vitro and in vivo and, in contrast to other reports, can induce developmental abnormalities in the fetus...
  75. pmc Development of focal segmental glomerulosclerosis after anabolic steroid abuse
    Leal C Herlitz
    Columbia University College of Physicians and Surgeons, Department of Pathology, New York, NY 10032, USA
    J Am Soc Nephrol 21:163-72. 2010
    ..Because of the expected rise in serum creatinine as a result of increased muscle mass in bodybuilders, this complication is likely underrecognized...
  76. ncbi The use of omic technologies for biomarker development to trace functions of anabolic agents
    Irmgard Riedmaier
    Physiology Weihenstephan, Technische Universitaet Muenchen, Weihenstephaner Berg 3, 85354 Freising, Germany
    J Chromatogr A 1216:8192-9. 2009
    ..to develop new screening technologies for a broad range of illegal drugs including newly designed xenobiotic anabolic agents. The use of omic technologies like, transcriptomics, proteomics or metabolomics is a promising approach to ..
  77. ncbi Adolescent use of anabolic-androgenic steroids and relations to self-reports of social, personality and health aspects
    A M Kindlundh
    Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, PO Box 591, S 751 24 Uppsala, Sweden
    Eur J Public Health 11:322-8. 2001
    ..However, the risk profile of AAS use is still not well understood. This study analysed the importance of social, personality and health factors for the use of AAS...
  78. ncbi Effect of anabolic steroids on mitochondria and sarcotubular system of skeletal muscle
    A Saborido
    Department of Biochemistry and Molecular Biology I, Faculty of Chemistry, Complutense University, Madrid, Spain
    J Appl Physiol (1985) 70:1038-43. 1991
    ..The present data indicate that anabolic/androgenic steroids can affect mitochondrial and sarcotubular enzymes in skeletal muscle. The effects are muscle-type specific...
  79. ncbi The prevalence of the use of androgenic anabolic steroids by adolescents in a county of Sweden
    S Nilsson
    Department of Primary Health Care, Neptun kliniken, Södra Hamnvägen 4, 43244 Varberg, Sweden
    Eur J Public Health 11:195-7. 2001
    ..This study was undertaken to examine the prevalence of the misuse--the non-medical use--of androgenic anabolic steroids among adolescents in a county of Sweden...
  80. ncbi Anabolic agents for improving muscle regeneration and function after injury
    Gordon S Lynch
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:852-8. 2008
    ....
  81. ncbi Anabolic steroid use: patterns of use and detection of doping
    Michael R Graham
    Department of Health and Exercise Science, School of Applied Science, University of Glamorgan, Pontypridd, UK
    Sports Med 38:505-25. 2008
    ..The knowledge acquired by such work can only assist in the education of individuals who use such doping agents, with a view to minimizing health risks and hopefully once again create a level playing field in sport...
  82. ncbi Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroids
    F Molano
    Department of Biochemistry and Molecular Biology I, Faculty of Chemistry, Complutense University, Madrid, Spain
    Med Sci Sports Exerc 31:243-50. 1999
    ....
  83. ncbi Determination of 13C/12C ratios of endogenous urinary steroids: method validation, reference population and application to doping control purposes
    Thomas Piper
    Institute of Biochemistry, German Sport University Cologne, Carl Diem Weg 6, 50933 Koln, Germany
    Rapid Commun Mass Spectrom 22:2161-75. 2008
    ..In order to determine naturally occurring (13)C/(12)C ratios of all implemented steroids, a reference population of n = 61 subjects was measured to enable the calculation of reference limits for all relevant steroidal Delta values...
  84. ncbi High amounts of 17-methylated anabolic-androgenic steroids in effervescent tablets on the dietary supplement market
    Maria K Parr
    Centre for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Carl Diem Weg 6, 50933 Cologne, Germany
    Biomed Chromatogr 21:164-8. 2007
    ..The quantitation of metandienone, norandrostenedione, and stanozolol was performed using HPLC-DAD...
  85. ncbi Abuse of anabolic-androgenic steroids and bodybuilding acne: an underestimated health problem
    Bodo Melnik
    Department of Dermatology, Environmental Medicine and Health Science, Division of Human Sciences, University of OsnabrYck, Germany
    J Dtsch Dermatol Ges 5:110-7. 2007
    ..Both acne conglobata and acne fulminans can be induced by AAS abuse. The dermatologist should recognize bodybuilding acne, address the AAS abuse, and warn the patient about other potential hazards...
  86. ncbi Metabolism and excretion of anabolic steroids in doping control--new steroids and new insights
    Peter Van Eenoo
    Doping control laboratory DoCoLab, Ghent University Ugent, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Steroid Biochem Mol Biol 101:161-78. 2006
    ..Additionally an update and insight on new aspects for "older" steroids with respect to doping control is given...
  87. ncbi Psychiatric side effects induced by supraphysiological doses of combinations of anabolic steroids correlate to the severity of abuse
    Thomas A Pagonis
    Department of Psychiatry, University Hospital, Thessaly University Medical School, Larissa, Greece
    Eur Psychiatry 21:551-62. 2006
    ..The hypothesis tested by the study was that the use of AAS induces a wide range of psychological side effects whose impact and emergence is dependent upon the severity of the abuse...
  88. ncbi Anabolic androgens restore mating after sexual satiety in male rats
    Bryan V Phillips-Farfán
    Department of Pharmacobiology, CINVESTAV, Mexico City, Mexico
    Pharmacol Biochem Behav 89:241-6. 2008
    ..This effect was only blocked by the combined administration of flutamide plus tamoxifen. The data suggest that anabolic androgens metabolites synergize to restore mating behavior after sexual satiety...
  89. ncbi [A case of a tumorsimulating expansion caused by anabolic androgen steroids in body building]
    G Kienbacher
    Universitätsklinik für Orthopädie, Medizinische Universitat Graz, Osterreich
    Sportverletz Sportschaden 21:195-8. 2007
    ..Erwinia species are associated with plants, Pseudomonas fluorescens is found in feces, sewage and soil. It is obvious, that the infection is caused by an inappropriate injection of AAS or by the contamination of the injected substances...
  90. ncbi [Anesthesia and bodybuilding]
    Frank Hokema
    Klinik und Poliklinik für Anästhesiologie und Intensivtherapie des Universitätsklinikums Leipzig
    Anasthesiol Intensivmed Notfallmed Schmerzther 43:354-8. 2008
    ..The anesthesia risk is not exactly known but seems to be determined mainly by cardiovascular events like myocardial ischemia and dysrhythmias...
  91. ncbi Pulmonary embolism associated with the use of anabolic steroids
    Sissela Liljeqvist
    Department of Internal Medicine, Karolinska Institutet, Sodersjukhuset, SE 118 83, Stockholm, Sweden
    Eur J Intern Med 19:214-5. 2008
    ..The thromboembolic episodes in this previously healthy patient were in all probability associated with intramuscular injections of testosterone and nandrolone, to which there is a clear correlation in time...
  92. ncbi Mass spectrometric detection of and similarities between 1-androgens
    K Verheyden
    Ghent University, Faculty of Veterinary Medicine, Department of Veterinary Public Health and Food Safety, Laboratory of Chemical Analysis, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Anal Chim Acta 586:57-72. 2007
    ..Similarities in spectra to known analytes, which may lead to pitfalls in the interpretation of the derivatised analytes, are discussed...
  93. ncbi Rapid screening of doping agents in human urine by vacuum MALDI-linear ion trap mass spectrometry
    Hari Kosanam
    Department of Chemistry, University of Memphis, Memphis, Tennessee 38152, USA
    Anal Chem 79:6020-6. 2007
    ..Hence, vMALDI-LIT/MS can be used as a rapid screening method to complement the traditional GC/MS and LC/MS techniques for simultaneous identification, confirmation, and quantification of doping agents in urine...
  94. ncbi Pharmacokinetics of boldenone and stanozolol and the results of quantification of anabolic and androgenic steroids in race horses and nonrace horses
    L R Soma
    School of Veterinary Medicine, New Bolton Center Campus, University of Pennsylvania, Kennett Square, PA 19348, USA
    J Vet Pharmacol Ther 30:101-8. 2007
    ..Plasma concentrations of endogenous 19-nortestosterone (nandrolone; NA) from racing and nonracing males were 50.2+/-5.5 and 71.8+/-4.6 pg/mL, respectively...
  95. ncbi Fullerene-C60-modified electrode as a sensitive voltammetric sensor for detection of nandrolone--an anabolic steroid used in doping
    Rajendra N Goyal
    Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India
    Anal Chim Acta 597:82-9. 2007
    ..The described method was successfully employed for the determination of nandrolone in human serum and urine samples. A cross-validation of observed results by GC-MS indicates that the results are in good agreement with each other...
  96. ncbi Analysis of exogenous nandrolone metabolite in horse urine by gas chromatography/combustion/carbon isotope ratio mass spectrometry
    Masayuki Yamada
    Laboratory of Racing Chemistry, 1731 2 Tsurutamachi, Utsunomiya, Tochigi 320 0851, Japan
    J Pharm Biomed Anal 45:654-8. 2007
    ....
  97. ncbi Anabolic-androgenic steroids: use and abuse in pediatric patients
    Julie M Kerr
    Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272, USA
    Pediatr Clin North Am 54:771-85, xii. 2007
    ....
  98. ncbi Development and validation of a qualitative screening method for the detection of exogenous anabolic steroids in urine by liquid chromatography-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, Department of Clinical Chemistry, Microbiology and Immunology, University of Ghent, Technologiepark 30, 9052, Zwijnaarde, Belgium
    Anal Bioanal Chem 389:1209-24. 2007
    ..Limits of detection between 1 and 10 ng/ml were obtained for most analytes which fulfil current requirements. The applicability of the method was shown by analysing positive samples...
  99. ncbi [Identification of candidate genes and expression profiles, as doping biomarkers]
    A Paparini
    Dipartimento di Scienze della Salute, Unità di Sanità Pubblica, Istituto Universitario Scienze Motorie, Roma
    Ann Ig 19:303-14. 2007
    ..This pilot study shows the potential of molecular biology-based strategies in anti-doping controls...
  100. ncbi It's not supposed to happen this way...a cautionary tale
    Mark A Roettger
    Academy for Sports Dentistry, USA
    Northwest Dent 86:21. 2007
  101. ncbi Detrimental effects of anabolic steroids on human endothelial cells
    Sandra D'Ascenzo
    Department of Experimental Medicine, University of L Aquila, Via Vetoio Coppito 2, L Aquila 67100, Italy
    Toxicol Lett 169:129-36. 2007
    ..As a whole, this study demonstrates that AAS might alter endothelial homeostasis, predisposing to the early endothelial cell activation that is responsible for vascular complications observed frequently in AAS users...

Research Grants64

  1. Novel Drug VS-105 for Treatment of Osteoporosis
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..Current treatments for osteoporosis include several anti-resorptive (or anti-catabolic) and some anabolic agents. VDRMs such as calcitriol are currently used to treat osteoporosis in several ex-US countries...
  2. Eicosapentaenoic acid and protein modulation to induce anabolism in COPD
    MARIELLE PKJ ENGELEN; Fiscal Year: 2012
    ..like the low daily dosage of EPA+DHA, the delayed plasma EPA peak after intake, as well as the absence of anabolic agents like proteins and specific amino acids (ie leucine) might explain that EPA+DHA treatment was unsuccessful...
  3. Synthesis of bone-selective osteogenic oxysterols
    Frank Stappenbeck; Fiscal Year: 2013
    ..will provide the rationale for future investigation of the therapeutic effects of Oxy133-BTA analogues in animal models of osteoporosis that may ultimately lead to the development of new bone anabolic agents fit for use in humans.
  4. FGF SIGNALING IN SKELETAL DEVELOPMENT, HOMEOSTASIS AND AGING
    David M Ornitz; Fiscal Year: 2013
    ..of skeletal aging is a decline in the rate of bone formation, and there exists an unmet clinical need for anabolic agents to offset this decline...
  5. Genetics of Osteoblast Differentiation
    Matthew Aaron Hibbs; Fiscal Year: 2012
    ..One of the most promising therapeutic avenues for the treatment of osteoporosis is the development of anabolic agents which promote osteoblast function...
  6. A megakaryocyte/PGE2/osteoblast triad in the normal and aged niche
    Louis M Pelus; Fiscal Year: 2013
    ..innovative with respect to the potential role of MKs, alone or with PGE2 (a known bone anabolic molecule), as anabolic agents to improve bone health, and understanding the normal bone and hematopoietic loss of function as a consequence ..
  7. Extrarenal Functions of Polycystin-1
    L Darryl Quarles; Fiscal Year: 2013
    ..cilium complex as a new anabolic pathway in bone as well as possibly provide a new target for developing anabolic agents to treat osteoporotic disorders...
  8. Mechanisms of Age-Related Skeletal Resistance to BMP-7 and IGF-I
    John C Lee; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bone Morphogenetic proteins (BMPs) show great promise as bone anabolic agents in several therapeutic settings...
  9. BONE TARGETED DELIVERY OF ANABOLIC AGENTS
    JINDRICH H KOPECEK; Fiscal Year: 2011
    ....
  10. Mechanobiological Mechanism for Inflammaory Bone Loss
    Francis Young In Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Current therapeutics such as bisphosphonates or anabolic agents do not always effectively prevent or treat osteoporosis and inflammatory bone loss in rheumatoid arthritis, periodontitis, and implant ..
  11. EFFECTS OF AGE ON SIGNALING IN HUMAN OSTEOBLASTOGENESIS
    Julie Glowacki; Fiscal Year: 2010
    ..aim tests the hypotheses that with aging, there is diminished signal transduction in response to osteo-anabolic agents like parathyroid hormone (PTH) and sex hormones and the third specific aim tests whether combination ..
  12. Targeting bone homing of the MSCs to augment bone formation
    Wei Yao; Fiscal Year: 2010
    ..In addition, we will evaluate the efficacy of combination low-dose anabolic agents and Bis-LLP2A in the augmentation of bone formation in osteoporotic animals. 2...
  13. Myeloma-Microenvironment Interaction Dynamics
    Shmuel Yaccoby; Fiscal Year: 2012
    ..microenvironmental-targeted therapies associated with activation of osteoclasts and explore the use of bone-anabolic agents and SLRPs as effective and safe strategies to improve patients'quality of life and control myeloma...
  14. Structural, Molecular, and Functional Specialization in Osteocyte Mechanosensing
    Sheldon Weinbaum; Fiscal Year: 2013
    ..though changes osteocyte mechanosensitivity have been implicated in regulating the effect of both bone anabolic agents and sex hormones...
  15. Treatment of Skeletal Muscle Dysfunction in ICU Patients
    Gerald S Supinski; Fiscal Year: 2013
    ..The purpose of the present proposal is to address this issue and evaluate the impact of anabolic agents on strength and outcomes in a large, diagnostically broad based MICU patient population...
  16. The Norepinephrine Transporter as a Novel Target for a Bone Anabolic Treatment
    Florent Elefteriou; Fiscal Year: 2013
    ..preliminary results identify NET as a potential molecular target for drug discovery of a novel class of bone anabolic agents and have led us to hypothesize that clinically available selective NET blockers could promote bone gain...
  17. Actions of Endoxifen on the Skeleton
    Anne Gingery; Fiscal Year: 2013
    ..Thus, a significant need exists for the development of additional bone anabolic agents to prevent or treat this debilitating disease...
  18. REGULATION OF RUNX-2 TRANSCRIPTIONAL ACTIVITY
    Jennifer J Westendorf; Fiscal Year: 2010
    ..Our previous work indicates that Hdac inhibitors are potential anabolic agents. Thus, it is our expectation that this work will provide new perspectives and knowledge into treatment of ..
  19. 4th NY Skeletal Biology and Medicine Conference
    Mone Zaidi; Fiscal Year: 2011
    ..therapeutic directions to focus on multiple modes of intervention involving anti-resorptive and importantly anabolic agents. A better understanding of the fundamentals of skeletal biology, the pathophysiology associated with skeletal ..
  20. Mechanisms of WNT signaling in bone
    Fanxin Long; Fiscal Year: 2013
    ..provided by applicant): Wnt signaling provides a promising target pathway for developing novel bone anabolic agents. Most studies to date have supported a model in which autocrine or paracrine Wnt signaling in osteoblast-..
  21. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..role of the steroid 5-alpha-reductase system, and has immediate clinical relevance in establishing whether selective androgen receptor modulators that do not undergo 5-alpha reduction would be useful as anabolic agents.
  22. 11th International Conference on Cancer-Induced Bone Disease in Chicago, IL, in p
    KEVIN BALIOZIAN; Fiscal Year: 2012
    ..Molecularly Targeted Therapies, Translating Trial Results into Clinical Practice, Therapy Resistance, Anabolic Agents, Primary Bone Tumors and Tumor-associated Stroma...
  23. Indian Hedgehog Signaling in Osteoblast Differentiation
    Fanxin Long; Fiscal Year: 2013
    ..osteoblast development in the embryo, providing a promising target pathway for development of bone anabolic agents. This proposal is designed to elucidate the molecular mechanism through which Hh controls osteoblast ..
  24. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2004
    ..versus alternative management strategies, including parenteral nutrition, naso-gastric feeding and anabolic agents. (2A) Compare, in the second arm of the above clinical trial, the efficacy of high versus standard dose ..
  25. Mentored Patient-Oriented Research Career Development Aw
    Zhenqi Liu; Fiscal Year: 2004
    ..One of the possible mechanisms is glucocorticoid- or thyroid hormone-induced resistance to the anabolic agents in skeletal muscle...
  26. ANABOLIC HORMONES IN NUTRITION SUPPORT
    Thomas Ziegler; Fiscal Year: 1999
    ..exchange to summarize recent clinical trials, prior experience, and relevant animal studies on the use anabolic agents in nutritional support...
  27. AAV-mediated gene therapy for metabolic bone disease
    Selvarangan Ponnazhagan; Fiscal Year: 2009
    ..Treatments to increase bone density by anabolic agents are limited due to ineffective delivery methods and a short half-life of the drugs and purified proteins...
  28. Anabolic Skeletal Agents for Osteoporosis
    Andrew Stewart; Fiscal Year: 2004
    ..the past year, the FDA has approved parathyroid hormone, the first effective drug in a new class of skeletal anabolic agents. This event, together with rapid and extensive advances in the understanding of osteoblastic bone formation, ..
  29. ANABOLIC ACTIONS OF Ca2+-RECEPTOR IN OSTEOBLASTIC CELLS
    Naibedya Chattopadhyay; Fiscal Year: 2005
    ..A major goal of osteoporosis research is to develop effective anabolic agents that will enhance osteoblast recruitment, differentiation and/or their ability to form mineralized bone...
  30. 3rd Skeletal Biology and Medicine Conference
    Mone Zaidi; Fiscal Year: 2009
    ..therapeutic directions to focus on multiple modes of intervention involving anti-resorptive and importantly anabolic agents. Also significant is the role that other physiological systems or disease states such as the immune system, ..
  31. RESTORATION OF LOST BONE MASS AFTER OVARIECTOMY
    Thomas Wronski; Fiscal Year: 2007
    ..human and animal studies indicate that the severely osteopenic skeleton fails to respond adequately to bone anabolic agents such as NaF and PTH, probably due to lack of adequate numbers of bone spicules that serve as a template for ..
  32. EFFECTS OF ANABOLIC AGENTS ON HEALING OF BONE DEFECTS
    Di Chen; Fiscal Year: 2000
    ..This project aims to confirm these effects in several standard preclinical models to determine potential efficacy as a therapeutic local bone growth stimulant. ..
  33. 2005 Bones & Teeth Gordon Conference
    Rene St Arnaud; Fiscal Year: 2005
    ..and calcification; teeth/craniofacial biology; signaling/cytokines; osteoclasts/bone resorption; and skeletal anabolic agents. The discussion leaders and speakers selected to date are among the finest investigators in the international ..
  34. Oxysterols Regulate Marrow Stromal Cell Differentiation
    Farhad Parhami; Fiscal Year: 2009
    ..Novel bone anabolic agents that stimulate osteoblast activity and bone formation are necessary for improved interventions in ..
  35. Effects of Insulin on Post-Burn Hypermetabolism
    Steven Wolf; Fiscal Year: 2007
    ..Recent studies done by our group indicate that anabolic agents such as insulin decrease protein catabolism when used over short terms in the severely burned...
  36. IDENTIFICATION OF ANABOLIC AGENTS FOR BONE GROWTH
    Gloria Gutierrez; Fiscal Year: 1999
    ..This project aims to characterize one such compound we have identified. ..
  37. Skeletal Biology and Medicine Conference
    Mone Zaidi; Fiscal Year: 2007
    ..therapeutic directions to focus on multiple modes of intervention involving anti-resorptive treatments and anabolic agents. Also significant is the role that other physiological systems or disease states such as the immune system, ..
  38. Somatomedin: Autologous Regulator of Bone Formation
    Ernesto Canalis; Fiscal Year: 2008
    ..These investigations should clarify the role of CHOP in bone cell differentiation and function. [unreadable] [unreadable]..
  39. NEURAL AND BEHAVIORAL ACTIONS OF ANABOLIC STEROIDS
    Ann Clark; Fiscal Year: 2003
    ....
  40. AAS and the Neurobiology of Social Behaviors
    Ann Clark; Fiscal Year: 2009
    ..Such data may be relevant towards understanding not only the effects of AAS, but of other abused drugs that act via GABAergic pathways. ..
  41. Assessment of Appearance and Performance Enhancing Drug Use
    Thomas Hildebrandt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. Targeting Bone Remodeling For the Treatment of Osteoporosis
    John Bilezikian; Fiscal Year: 2008
    ..The purpose of this meeting is to bring together experts from these interdisciplinary fields so as to define the direction of the future. ..
  43. Muscle Perfusion and Protein Metabolism in Elderly
    Melinda Sheffield Moore; Fiscal Year: 2009
    ..Results from these studies will provide evidence as to the regulatory role of increased muscle perfusion, amino acid supplementation and aerobic exercise as means of improving skeletal muscle protein synthesis in the elderly. ..
  44. Seasonal Bone Loss in Mice
    Clifford Rosen; Fiscal Year: 2008
    ..unreadable] Understanding the impact of circadian and circannual rhythms on the skeleton will afford greater insight into homeostatic mechanisms controlling bone maintenance. [unreadable] [unreadable] [unreadable]..
  45. SUN VALLEY SKELETAL TISSUE WORKSHOP
    WEBSTER JEE; Fiscal Year: 2003
    ..A plan is presented for supporting junior scientists and for encouraging interaction with other junior and senior scientists. There are plans to advertise and distribute a summary of the workshop, partly using Web-based, resources. ..
  46. METABOLIC EFFECTS OF PROTEASE INHIBITORS IN HIV DISEASE
    Kathleen Mulligan; Fiscal Year: 2002
    ....
  47. CAN PTH REVERSE GLUCOCORTICOID INDUCED OSTEOPOROSIS
    Nancy Lane; Fiscal Year: 2002
    ....
  48. COUNTER REGULATION OF STRESS MEDIATED IMMUNOSUPPRESSION
    David Padgett; Fiscal Year: 2002
    ..The long-term goals should provide insight into the relationships between the nervous, endocrine, and immune systems and how inflammatory immune responses can be regulated at many different central and peripheral levels. ..
  49. BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESS
    Robert Heaney; Fiscal Year: 2001
    ....
  50. The Epidemiology and Genetics of Hip OA in Elderly Men
    Nancy Lane; Fiscal Year: 2009
    ..After determining the prevalence of hip OA in the Mr. OS cohort we will perform case-control studies of candidate genes associated with bone and cartilage metabolism. ..
  51. Genetics, Brain Activity, and Relapse to Alcoholism
    Kirk Brower; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  52. Risk Factors for Anabolic-Androgenic Steroid Abuse
    HARRISON POPE; Fiscal Year: 2009
    ....
  53. Young Investigators Initiative Workshop (U13)
    Nancy Lane; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Bone-Sparing by Ca Salts With & Without Extra Phosphorus
    Robert Heaney; Fiscal Year: 2008
    ..1 Description, ..
  55. Small Grant Program for Conference Support (R13)
    Nancy Lane; Fiscal Year: 2007
    ..To review the issues they need to address to fully develop their submissions, if participants have not yet submitted proposals. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  56. EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONE
    Joel Finkelstein; Fiscal Year: 2008
    ..Without continued K24 support, I will need to increase my clinical activities, reduce my research time, and forego training of new clinical investigators. ..
  57. Androgen action in bone: Overexpression of AR
    Kristine M Wiren; Fiscal Year: 2010
    ..Non-aromatizable androgens such as Salpha- dihydrotestosterohe (DHT), are anabolic agents that increase bone mass by stimulation of bone formation, and thus represent an important therapeutic class...
  58. DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMES
    Judith Rabkin; Fiscal Year: 2004
    ..The data collected in the preliminary study will be used in the full-scale study. ..
  59. PATHOBIOLOGY OF THE OSTEOCLAST IN PAGETS DISEASE
    G Roodman; Fiscal Year: 2002
    ..abstract_text> ..
  60. Prescription Drug Abuse Among College Students
    SEAN MCCABE; Fiscal Year: 2005
    ....
  61. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2003
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  62. GABA A RECEPTOR MODULATORS IN THE DEVELOPING RAT FOREBRA
    Leslie Henderson; Fiscal Year: 2003
    ....
  63. DEVELOPMENT OF MATURE ZEBRAFISH AS AN ANIMAL MODEL
    Evan Keller; Fiscal Year: 2006
    ....