desoxycorticosterone

Summary

Summary: 21-Hydroxypregn-4-ene-3,20-dione. Mineralocorticoid. Desoxycorticosterone acetate (DOCA) is used as replacement therapy in Addison's Disease.

Top Publications

  1. ncbi Systemic ethanol administration elevates deoxycorticosterone levels and chronic ethanol exposure attenuates this response
    Rahul T Khisti
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1049:104-11. 2005
  2. ncbi Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertensive rats
    L Jin
    Department of Physiology, Medical College of Georgia, Augusta, GA, USA
    J Physiol Pharmacol 57:343-57. 2006
  3. pmc Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats
    Emilie C Viel
    Lady Davis Institute for Medical Research, Montreal, QC, Canada H3T 1E2
    Am J Physiol Heart Circ Physiol 295:H281-8. 2008
  4. pmc Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans
    Patrizia Porcu
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 34:432-42. 2010
  5. ncbi Eel (Anguilla japonica) testis 11beta-hydroxylase gene is expressed in interrenal tissue and its product lacks aldosterone synthesizing activity
    J Q Jiang
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki, Japan
    Mol Cell Endocrinol 146:207-11. 1998
  6. pmc Allopurinol does not decrease blood pressure or prevent the development of hypertension in the deoxycorticosterone acetate-salt rat model
    Theodora Szasz
    Pharmacology and Toxicology Department, Michigan State University, East Lansing, MI 48824 1317, USA
    J Cardiovasc Pharmacol 56:627-34. 2010
  7. pmc 2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1
    Seyhan Sahan-Firat
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Heart Circ Physiol 299:H1891-901. 2010
  8. ncbi Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats
    Hui Xu
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, Mich 48824, USA
    Hypertension 43:329-34. 2004
  9. ncbi Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder
    Maria Carolina Hardoy
    Department of Public Health, University of Cagliari, Cagliari 09100, Italy
    J Clin Psychopharmacol 26:379-84. 2006
  10. ncbi Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms
    Glaucia E Callera
    Kidney Research Centre, Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Clin Sci (Lond) 110:243-53. 2006

Research Grants

  1. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
  2. EICOSANOIDS, VASCULAR TONE AND BLOOD PRESSURE
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
  3. Role of H,K-ATPase in the Action of Mineralocorticoids
    Charles S Wingo; Fiscal Year: 2013
  4. STEROIDS IN ADRENAL REGENERATION HYPERTENSION
    Celso Gomez Sanchez; Fiscal Year: 1980
  5. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2008
  6. Paraventricular Nucleus Signaling Mechanisms in Hypertension
    CARRIE NORTHCOTT; Fiscal Year: 2008
  7. ROS and NO interaction in the PVN during hypertension?
    CARRIE NORTHCOTT; Fiscal Year: 2006
  8. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2009
  9. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
  10. Mechanisms of altered venous tone in hypertension
    ALEX PEREZ RIVERA; Fiscal Year: 2005

Detail Information

Publications195 found, 100 shown here

  1. ncbi Systemic ethanol administration elevates deoxycorticosterone levels and chronic ethanol exposure attenuates this response
    Rahul T Khisti
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1049:104-11. 2005
    ..These findings suggest that acute ethanol increases DOC levels in ethanol naïve rats and chronic ethanol consumption induces tolerance to ethanol-induced increases in DOC levels...
  2. ncbi Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertensive rats
    L Jin
    Department of Physiology, Medical College of Georgia, Augusta, GA, USA
    J Physiol Pharmacol 57:343-57. 2006
    ..These data suggest that renal injury characteristic of mineralocorticoid hypertension is associated with oxidative stress and is partly independent of blood pressure...
  3. pmc Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats
    Emilie C Viel
    Lady Davis Institute for Medical Research, Montreal, QC, Canada H3T 1E2
    Am J Physiol Heart Circ Physiol 295:H281-8. 2008
    ..Our findings demonstrate the involvement of ET(A) receptor-modulated O(2)(*-) derived from XO and from mitochondrial oxidative enzymes in arteries from DOCA-salt rats...
  4. pmc Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans
    Patrizia Porcu
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 34:432-42. 2010
    ....
  5. ncbi Eel (Anguilla japonica) testis 11beta-hydroxylase gene is expressed in interrenal tissue and its product lacks aldosterone synthesizing activity
    J Q Jiang
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki, Japan
    Mol Cell Endocrinol 146:207-11. 1998
    ..Immunohistochemistry using an antiserum against P450(11beta) also revealed strong immunostaining in interrenal cells...
  6. pmc Allopurinol does not decrease blood pressure or prevent the development of hypertension in the deoxycorticosterone acetate-salt rat model
    Theodora Szasz
    Pharmacology and Toxicology Department, Michigan State University, East Lansing, MI 48824 1317, USA
    J Cardiovasc Pharmacol 56:627-34. 2010
    ..We conclude that XO does not play an important role in the development or maintenance of hypertension in the rat DOCA-salt hypertension model...
  7. pmc 2,3',4,5'-Tetramethoxystilbene prevents deoxycorticosterone-salt-induced hypertension: contribution of cytochrome P-450 1B1
    Seyhan Sahan-Firat
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Heart Circ Physiol 299:H1891-901. 2010
    ....
  8. ncbi Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats
    Hui Xu
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, Mich 48824, USA
    Hypertension 43:329-34. 2004
    ..It is concluded that depressor responses and decreases in HR and RSNA caused by acute tempol treatment are caused by direct sympathetic nerve activity inhibition that is not accompanied by SOD-mimetic action in the aorta or vena cava...
  9. ncbi Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder
    Maria Carolina Hardoy
    Department of Public Health, University of Cagliari, Cagliari 09100, Italy
    J Clin Psychopharmacol 26:379-84. 2006
    ..These differences did not seem to be attributable simply to drug treatment or to comorbidity with other psychiatric conditions in the patients...
  10. ncbi Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms
    Glaucia E Callera
    Kidney Research Centre, Ottawa Health Research Institute, University of Ottawa, Ottawa, Canada
    Clin Sci (Lond) 110:243-53. 2006
    ..Mitochondria may play a role in ET-1-driven oxidative stress, as evidenced by increased mitochondrial-derived ROS in this model of hypertension...
  11. ncbi Enhanced contraction to 5-hydroxytryptamine is not due to "unmasking" of 5-hydroxytryptamine(1b) receptors in the mesenteric artery of the deoxycorticosterone acetate-salt rat
    A K Banes
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 38:891-5. 2001
    ..These data support the conclusions that 5-HT(1B) receptors mediate contraction in mesenteric arteries from hypertensive rats and that this enhanced response to 5-HT is not due to membrane depolarization alone...
  12. ncbi Deoxycorticosterone upregulates PDS (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension
    Jill W Verlander
    Department of Medicine, University of Florida College of Medicine, Gainesville, USA
    Hypertension 42:356-62. 2003
    ..We conclude that pendrin is upregulated with aldosterone analogues and is critical in the pathogenesis of mineralocorticoid-induced hypertension and metabolic alkalosis...
  13. ncbi 5-Hydroxytryptamine lowers blood pressure in normotensive and hypertensive rats
    Jessica Diaz
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Pharmacol Exp Ther 325:1031-8. 2008
    ..5 g/l in water) prevented the fall in blood pressure to 5-HT. We conclude that chronic exogenous 5-HT reduces blood pressure in normotensive and hypertensive rats through mechanisms critically dependent on NOS...
  14. pmc Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, 3027 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychoneuroendocrinology 33:214-26. 2008
    ..Further, alcohol-dependent patients show a blunted PREG-S response to adrenal stimulation and a delayed deoxycorticosterone response to oCRH challenge...
  15. ncbi Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7178, USA
    Psychopharmacology (Berl) 186:293-301. 2006
    ..However, little data are available for male nonhuman primates...
  16. ncbi Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility
    Doodipala S Reddy
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 22:3795-805. 2002
    ....
  17. ncbi Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats
    Laura E O'Dell
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Pharmacol 484:241-7. 2004
    ..This response was followed by the further secretion of the anxiolytic neuroactive steroids allopregnanolone and allotetrahydrodeoxycorticosterone, both of which appeared to be of adrenal and gonadal origin...
  18. ncbi Progesterone oxidation by cytochrome P450 2D isoforms in the brain
    T Hiroi
    Department of Chemical Biology, Osaka City University Medical School, Osaka 545 8585, Japan
    Endocrinology 142:3901-8. 2001
    ..Collectively, our findings support the idea that cytochrome P450 2D may be involved in the regulation (metabolism and/or synthesis) of endogenous neuroactive steroids, such as progesterone and its derivatives, in brain tissues...
  19. ncbi 11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor
    A Sturm
    Station Commune de Recherche en Ichtyophysiologie, Biodiversité et Environnement, Institut National de la Recherche Agonomique, Institut Fedératif de Recherche 98, 35042 Rennes, France
    Endocrinology 146:47-55. 2005
    ..1 +/- 0.3 x 10(-9) and 3.7 +/- 1.9 x 10(-9) M, respectively). A similar response was observed in transactivation assays with rtMRb. These results are discussed in the view of reported circulating levels of corticosteroids in trout...
  20. ncbi Mechanisms of increased venous smooth muscle tone in desoxycorticosterone acetate-salt hypertension
    G D Fink
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
    Hypertension 35:464-9. 2000
    ..of the present study was to identify mechanisms that contribute to increased venous smooth muscle tone in desoxycorticosterone acetate (DOCA)-salt hypertension in rats...
  21. ncbi Upregulation of arterial serotonin 1B and 2B receptors in deoxycorticosterone acetate-salt hypertension
    Amy K L Banes
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824, USA
    Hypertension 39:394-8. 2002
    ....
  22. ncbi Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine
    Mariangela Serra
    Department of Experimental Biology, B Loddo, University of Cagliari, Italy
    J Psychopharmacol 16:133-8. 2002
    ....
  23. ncbi Hydration of rainbow trout oocyte during meiotic maturation and in vitro regulation by 17,20{beta}-dihydroxy-4-pregnen-3-one and cortisol
    Sylvain Milla
    Institut National de la Recherche Agronomique, INRA SCRIBE, IFR 140, Campus de Beaulieu, 35000 Rennes, France
    J Exp Biol 209:1147-56. 2006
    ..Together, these results suggest that cortisol could participate in the control of oocyte hydration and possibly in other periovulatory ovarian functions...
  24. ncbi Fluoxetine decreases concentrations of 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) in major depression
    A Strohle
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804, Munich, Germany
    J Psychiatr Res 34:183-6. 2000
    ..Our results give further evidence for a disequilibrium of 3 alpha-reduced neuroactive steroids in major depression, which is normalized by treatment with fluoxetine...
  25. pmc Extracellular signal-regulated kinase 1/2 activation, via downregulation of mitogen-activated protein kinase phosphatase 1, mediates sex differences in desoxycorticosterone acetate-salt hypertension vascular reactivity
    Fernanda R Giachini
    Medical College of Georgia, Department of Physiology, 1120 Fifteenth St, CA 2095, Augusta, GA 30912 3000, USA
    Hypertension 55:172-9. 2010
    ..Uninephrectomized male and female Sprague-Dawley rats received desoxycorticosterone acetate (DOCA) pellets (200 mg per animal) and saline to drink for 3 weeks...
  26. ncbi Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension
    Marc Iglarz
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 42:737-43. 2003
    ..Taken together, these data indicate a modulatory role of PPAR activators on cardiac remodeling in mineralocorticoid-induced hypertension, in part associated with decreased ET-1 production...
  27. ncbi Tempol, an antioxidant, restores endothelium-derived hyperpolarizing factor-mediated vasodilation during hypertension
    Ayotunde S O Adeagbo
    Department of Physiology and Biophysics, Health Sciences Center, A 1214, University of Louisville, Louisville, KY 40292, USA
    Eur J Pharmacol 481:91-100. 2003
    ..Our data also suggest that cyclooxygenase-2 mediates free radical production, and that free radicals modulate the EDHF-mediated vascular response in DOCA-salt induced hypertension...
  28. ncbi Heme oxygenase-mediated endothelial dysfunction in DOCA-salt, but not in spontaneously hypertensive, rat arterioles
    Fruzsina K Johnson
    Tulane Hypertension and Renal Center of Excellence, Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Physiol Heart Circ Physiol 286:H1681-7. 2004
    ..These results suggest that elevated HO-1 levels and activity, not resulting from hypertension per se, contribute to endothelial dysfunction in DOCA rats...
  29. ncbi Endothelin antagonist reduces hemodynamic responses to vasopressin in DOCA-salt hypertension
    M Yu
    Cardiovascular Risk Factor Reduction Unit and Department of Pharmacology, College of Medicine, Univesity of Saskatchewan, Saskatoon, Canada
    Am J Physiol Heart Circ Physiol 281:H2511-7. 2001
    ..These results suggest that endothelin contributes to the hemodynamic effects of vasopressin but not angiotensin II in the DOCA-salt model of hypertension...
  30. ncbi Contribution of endogenous endothelin in the enhanced coronary constriction in DOCA-salt hypertensive rats
    Esther Millette
    Groupe de Recherche sur le Systeme Nerveux Autonome, Faculte de Pharmacie, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada, H3C 3J7
    J Hypertens 21:115-23. 2003
    ....
  31. ncbi Comparison of the cardiovascular protection by omapatrilat and lisinopril treatments in DOCA-salt hypertension
    Esther Millette
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada, H3C 3J7
    J Hypertens 21:125-35. 2003
    ..To compare the cardiovascular protection provided by omapatrilat and lisinopril in an experimental model of hypertension...
  32. ncbi Ovarian hormones modulate endothelin-1 vascular reactivity and mRNA expression in DOCA-salt hypertensive rats
    F L David
    Departments of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, SP, Brazil
    Hypertension 38:692-6. 2001
    ..weeks later, rats were uninephrectomized and further randomized in DOCA-salt (subcutaneous injections of desoxycorticosterone and drinking water containing NaCl/KCl) and control normotensive (subcutaneous injections of vehicle and ..
  33. ncbi Mineralocorticoids upregulate arterial contraction to epidermal growth factor
    J A Florian
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824-1317, USA
    Am J Physiol Regul Integr Comp Physiol 281:R878-86. 2001
    ..These data indicate that arterial contraction to EGF may occur independent of hypertension and be stimulated by mineralocorticoids...
  34. ncbi The role of chloride in deoxycorticosterone hypertension: selective sodium loading by diet or drinking fluid
    J Kunes
    Center for Experimental Cardiovascular Research, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 53:149-54. 2004
    ....
  35. ncbi Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension
    Lixin Li
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
    Circulation 107:1053-8. 2003
    ..However, the mechanisms underlying superoxide production in low-renin hypertension are undefined...
  36. ncbi Cyclooxygenase-2 inhibitors attenuate increased blood pressure in renovascular hypertensive models, but not in deoxycorticosterone-salt hypertension
    Toshiaki Okumura
    Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan
    Hypertens Res 25:927-38. 2002
    ..These results suggest that COX-2 plays a significant role in the development of 2K1C and 1K1C renovascular hypertension, in addition to making a substantial contribution to the diuretic effect in the 1K1C model...
  37. ncbi Chronic endopeptidase inhibition in DOCA-salt hypertension: mechanism of cardiovascular protection
    Mohammad A Newaz
    Center for Cardiovascular Diseases, College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas 77004, USA
    Clin Exp Hypertens 25:335-47. 2003
    ..These effects suggest a correlation between endopeptidase-related reduction in ET-1 production and protection in DOCA-salt hypertension...
  38. ncbi Chronic V2 vasopressin receptor stimulation increases basal blood pressure and exacerbates deoxycorticosterone acetate-salt hypertension
    Sandrine Fernandes
    Institut National de la Sante et de la Recherche Medicale, Unité 367, Paris, France
    Endocrinology 143:2759-66. 2002
    ..These effects could be due at least in part to the sustained stimulation of sodium reabsorption by epithelial sodium channel in the distal part of the nephron, which promotes sodium retention...
  39. ncbi Effects of pergolide on blood pressure and tissue injury in DOCA-salt hypertension
    Mohammad A Newaz
    Center for Cardiovascular Diseases, College of Pharmacy and Health Sciences, Texas Southern University, Houston 77004, USA
    Blood Press 11:110-5. 2002
    ..These data suggest that the reduction of SBP by pergolide in DOCA-salt hypertension may be attributed to its natriuretic ability, not its ability to reduce superoxide generation or ET- 1 production...
  40. ncbi ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension
    Glaucia E Callera
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Hypertension 42:811-7. 2003
    ..5%. These in vivo findings indicate that increased vascular superoxide production is associated with activation of the endothelin system through ETA receptors in DOCA-salt hypertension, in apparently blood pressure-independent fashion...
  41. ncbi Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats
    Qian Pu
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    J Hypertens 20:899-907. 2002
    ..Here, we studied the relative roles of NEP and ACE inhibition and their effect on resistance artery structure and function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats...
  42. ncbi Effect of magnesium on mRNA expression and production of endothelin-1 in DOCA-salt hypertensive rats
    Nathalie Berthon
    Laboratoire Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, UFR Médecine et Pharmacie, Universite de Franche Comte, Besancon, France
    J Cardiovasc Pharmacol 42:24-31. 2003
    ..In conclusion, these findings suggest that the lowering effect of Mg supplementation on blood pressure requires an inhibitory effect on endothelin-1 activity and/or endothelin-1 production in DOCA-salt hypertensive rats...
  43. ncbi Role of ET-1 receptor binding and [Ca(2+)](i) in contraction of coronary arteries from DOCA-salt hypertensive rats
    Ararat D Giulumian
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912 2500, USA
    Am J Physiol Heart Circ Physiol 282:H1944-9. 2002
    ....
  44. ncbi Effects of L-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats
    Akira Niijima
    Niigata University School of Medicine, Asahimachidoori, Japan
    Auton Neurosci 97:99-102. 2002
    ....
  45. ncbi Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension
    Jie sheng Zheng
    Department of Pharmacology and Toxicology and the Neuroscience Program, B403 Life Sciences Building, Michigan State University, East Lansing, Mich 48824 1317, USA
    Circulation 108:1238-45. 2003
    ..However, the interaction between O2- and BH4 on endothelial function and the underlying mechanisms are unknown...
  46. ncbi Decreased endothelin binding and [Ca2+]i signaling in microvessels of DOCA-salt hypertensive rats
    Mariela M Molero
    Vascular Biology Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Hypertens 20:1799-805. 2002
    ..The present study was designed to determine whether down-regulation of endothelin receptors or altered Ca2+ signaling contribute to the decreased contraction to ET-1...
  47. ncbi Effects of brain mineralocorticoid receptor blockade on blood pressure and renal functions in DOCA-salt hypertension
    Kamal Rahmouni
    Institut de Pharmacologie, Faculte de Medecine, Universite Louis Pasteur, Strasbourg, France
    Eur J Pharmacol 436:207-16. 2002
    ..In conclusion, these results demonstrate that in rats with hypertension induced by DOCA-salt, brain mineralocorticoid receptor blockade affects renal function and blood pressure regulation...
  48. ncbi Antihypertensive effects of the essential oil of Alpinia zerumbet and its main constituent, terpinen-4-ol, in DOCA-salt hypertensive conscious rats
    Saad Lahlou
    Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, Recife PE, Brasil
    Fundam Clin Pharmacol 17:323-30. 2003
    ..The data further support our previous hypothesis that hypotensive effects of EOAZ are partially attributed to the actions of Trp-4-ol...
  49. ncbi p38 mitogen-activated protein kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats
    Bokyung Kim
    Department of Physiology, College of Medicine, Konkuk University, Choongju, Korea
    Hypertension 43:1086-91. 2004
    ....
  50. ncbi Increased O2*- production and upregulation of ETB receptors by sympathetic neurons in DOCA-salt hypertensive rats
    Xiaoling Dai
    Department of Physiology, Michigan State University, East Lansing, MI 48823, USA
    Hypertension 43:1048-54. 2004
    ....
  51. ncbi Role of presynaptic beta 2-adrenergic facilitation in the development and maintenance of DOCA-salt hypertension
    P Moreau
    , , , , Canada
    Am J Hypertens 6:1016-24. 1993
    ..abstract truncated at 250 words)..
  52. ncbi Alteration of prejunctional alpha 2-adrenergic autoinhibition in DOCA-salt hypertension
    P Moreau
    , , , Canada
    Am J Hypertens 8:287-93. 1995
    ..This dysfunction could in part explain the hyperactivity and hyperreactivity of the sympathetic nervous system observed in this model, and thus contribute to the elevation of blood pressure in DOCA-salt hypertension...
  53. ncbi Deoxycorticosterone acetate-salt rats: hypertension and sympathoexcitation driven by increased NaCl levels
    Theresa L O'Donaughy
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA
    Hypertension 47:680-5. 2006
    ..Collectively, these data suggest that increased NaCl levels contribute to sympathoexcitation and hypertension in DOCA-salt rats because of amplification of the NaCl signal by DOCA...
  54. ncbi Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats
    N Yokota
    University of Ottawa Heart Institute Research Centre, Ottawa Civic Hospital, Ontario, Canada
    Am J Hypertens 8:301-10. 1995
    ....
  55. ncbi Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats
    David Loch
    Department of Physiology and Pharmacology, School of Biomedical Sciences, The University of Queensland, Australia
    J Cardiovasc Pharmacol 47:396-404. 2006
    ..We conclude that the pleiotropic effects of rosuvastatin include attenuation of aspects of cardiovascular remodeling in the DOCA-salt model of hypertension in rats without altering systolic blood pressure...
  56. ncbi Extrarenal Na+ balance, volume, and blood pressure homeostasis in intact and ovariectomized deoxycorticosterone-acetate salt rats
    Jens Titze
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Hypertension 47:1101-7. 2006
    ..Extrarenal Na+ and volume balance seem to play an important role in long-term volume and MAP control...
  57. ncbi Contribution of central nitric oxide to the regulation of blood pressure and sodium balance in DOCA-salt hypertension
    Shinji Seto
    Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Cardiovasc Pharmacol 47:680-5. 2006
    ..These data suggested that, in DOCA-salt, central nitric oxide is involved in BP regulation through the dual action on sympathetic nervous activity and sodium balance...
  58. ncbi Attenuation of cardiovascular remodeling in DOCA-salt rats by the vasopeptidase inhibitor, omapatrilat
    David Loch
    Department of Physiology and Pharmacology, School of Biomedical Sciences, The University of Queensland, 4072, Australia
    Clin Exp Hypertens 28:475-88. 2006
    ....
  59. ncbi Central action of increased osmolality to support blood pressure in deoxycorticosterone acetate-salt rats
    Theresa L O'Donaughy
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland 97239, USA
    Hypertension 48:658-63. 2006
    ....
  60. ncbi Biomechanical response of arterial wall to DOCA-salt hypertension in growing and middle-aged rats
    Kozaburo Hayashi
    Research Institute of Technology, Okayama University of Science, 1 1 Ridai cho, Okayama 700 0005, Japan
    J Biomech 40:1583-93. 2007
    ..These results were essentially similar to previous ones observed in Goldblatt hypertension and in younger animals. Age-related differences in arterial wall remodeling were not clearly observed...
  61. ncbi The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    J Pharmacol Exp Ther 321:485-91. 2007
    ..However, it is the 5-HT2A receptor and not the 5-HT2B receptor that participates in these effects...
  62. ncbi Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase
    Rosario Jimenez
    Department of Pharmacology, School of Pharmacy, Spain
    Free Radic Biol Med 43:462-73. 2007
    ..All these results suggest that chronic treatment with RWPs prevents hypertension and vascular dysfunction. RWPs prevent vascular oxidative stress by inhibiting NADPH oxidase activity and/or by reducing ET-1 release...
  63. ncbi Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats
    Kazuhiro Ishimaru
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Pharmacol 50:187-94. 2007
    ....
  64. pmc Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Eur J Pharmacol 589:225-7. 2008
    ..Moreover, blood pressure elevated similarly (~50 mm Hg) in all strains given DOCA and salt. Thus, the lack of functional SERT did not prevent development of DOCA-salt induced hypertension or modify basal blood pressure significantly...
  65. ncbi Magnesium supplementation and deoxycorticosterone acetate--salt hypertension: effect on arterial mechanical properties and on activity of endothelin-1
    Nathalie Berthon
    Laboratoire Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, UFR Médecine et Pharmacie, Universite de Franche Comte, Besancon, France
    Can J Physiol Pharmacol 80:553-61. 2002
    ..These findings suggest that Mg supplementation prevents blood pressure elevation by attenuating peripheral resistance and by decreasing hypertrophic effect of endothelin-1 via inhibition of endothelin-1 production...
  66. ncbi Evolution of liver antioxidant status and iron implication during the development of deoxycorticosterone-saline hypertension in rats
    Fatiha Elhaïmeur
    Laboratoire de Physiologie Pharmacologie Nutrition Préventive Expérimentale, UFR des Sciences Médicales et Pharmaceutiques, 25030 Besancon Cedex, France
    Biol Trace Elem Res 107:263-76. 2005
    ....
  67. ncbi Concurrent administration of aqueous Azadirachta indica (neem) leaf extract with DOCA-salt prevents the development of hypertension and accompanying electrocardiogram changes in the rat
    Idongesit Obiefuna
    Department of Basic Medical Sciences, University of the West Indies
    Phytother Res 19:792-5. 2005
    ..Daily administration of 20 mg/kg neem-leaf extract concurrently with DOCA-salt for 5 weeks, prevents the development of hypertension and the accompanying alterations in the ECG patterns seen in DOCA-salt treated rats...
  68. pmc Role of endothelin and vasopressin in DOCA-salt hypertension
    M Yu
    Cardiovascular Risk Factor Reduction Unit and Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, S7N 5E5
    Br J Pharmacol 132:1447-54. 2001
    ..However, the magnitude of the contribution to the hypertensive state appears greater for ET than for AVP. Enhanced vascular responses to ET appear to contribute to this greater role...
  69. ncbi Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil
    Milagros Galisteo
    Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
    Planta Med 70:334-41. 2004
    ....
  70. ncbi Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism
    F Ammarguellat
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, , , Canada
    Circulation 103:319-24. 2001
    ..These results support the hypothesis of a role for endothelin-1 in cardiac collagen deposition in mineralocorticoid hypertension, which may have pathophysiological and pharmacological implications in hypertensive heart disease...
  71. ncbi Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats
    Satoshi Kagitani
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Hypertens 22:1007-15. 2004
    ....
  72. ncbi The effect of estrogen on serum nitric oxide concentrations in normotensive and DOCA Salt hypertensive ovariectomized rats
    M Nematbakhsh
    Department of Physiology, School of Medicine, Medical University of Isfahan, Isfahan, Iran
    Clin Chim Acta 344:53-7. 2004
    ..This study investigated the effect of estrogen on serum NO concentrations in normotensive and deoxycorticostrone acetate (DOCA) Salt hypertensive ovariectomized rats...
  73. ncbi Endothelial dysfunction in aortic rings and mesenteric beds isolated from deoxycorticosterone acetate hypertensive rats: possible involvement of protein kinase C
    Zahra Fatehi-Hassanabad
    Department of Physiology and Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, P O Box 91775 1843, Meshed, Iran
    Eur J Pharmacol 494:199-204. 2004
    ..Our data suggest that protein kinase C plays a crucial role in the endothelial dysfunction induced by hypertension...
  74. ncbi Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteries
    Kevin B Atkins
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0676, USA
    Am J Physiol Heart Circ Physiol 288:H235-43. 2005
    ....
  75. ncbi Microvascular responses to endothelin in deoxycorticosterone acetate-salt hypertensive rats
    H Zhao
    Department of Physiology and Biophysics, University of Louisville, School of Medicine, Kentucky 40292, USA
    Am J Hypertens 13:819-26. 2000
    ..However, the ET-B receptor-mediated vasoconstriction is potentiated during DOCA-salt hypertension...
  76. ncbi Endothelin in the splanchnic vascular bed of DOCA-salt hypertensive rats
    Hong Wang
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Physiol Heart Circ Physiol 288:H729-36. 2005
    ..These results argue against the hypothesis that increased venomotor tone in DOCA-salt hypertension is caused by increased ET-1 concentration around splanchnic venous smooth muscle cells...
  77. ncbi Enhanced hypotensive effects of the essential oil of Ocimum gratissimum leaves and its main constituent, eugenol, in DOCA-salt hypertensive conscious rats
    Leylliane Fátima Leal Interaminense
    Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Pernambuco PE, Brazil
    Planta Med 71:376-8. 2005
    ..This enhancement appears related mainly to an increase in EOOG-induced vascular smooth relaxation rather than to enhanced sympathetic nervous system activity in this hypertensive model...
  78. ncbi Blood pressure variability, cardiac baroreflex sensitivity and organ damage in experimentally hypertensive rats
    Di Song Wang
    Department of Pharmacology, Second Military Medical University, Shanghai, China
    Clin Exp Pharmacol Physiol 32:545-52. 2005
    ..The DOCA rats had the highest BPV and the l-NAME rats had the lowest BRS. Obvious organ damage was seen in all three hypertensive models 6 weeks after the induction of hypertension...
  79. ncbi Effect of chronic treatment with two different ET(A) selective endothelin receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats
    J S Li
    MRC Multidisciplinary Research Group on Hypertension, , , , Canada
    Am J Hypertens 11:554-62. 1998
    ....
  80. ncbi NAD(P)H oxidase/nitric oxide interactions in peroxisome proliferator activated receptor (PPAR)alpha-mediated cardiovascular effects
    Mohammad Newaz
    Center for Cardiovascular Diseases, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
    Mutat Res 579:163-71. 2005
    ..Thus, apart from inhibition of ET-1 production, PPARalpha activation exerts protective actions in hypertension via a mechanism that involves NO production and/or inhibition of NAD(P)H oxidase activity...
  81. ncbi High calcium diet effectively opposes the development of deoxycorticosterone-salt hypertension in rats
    H Mäkynen
    Department of Biomedical Sciences, University of Tampere, Finland
    Am J Hypertens 7:520-8. 1994
    ..In addition, the mineralocorticoid-salt treatment impaired relaxation responses of endothelium-intact arterial rings to acetylcholine, sodium nitroprusside, and isoproterenol.(ABSTRACT TRUNCATED AT 250 WORDS)..
  82. ncbi Comparison of human fetal hepatic and adrenal cytochrome P450 activities with some major gestational steroids and ethylmorphine as substrates
    A Rane
    Department of Clinical Pharmacology, Akademiska Hospital, Uppsala, Sweden
    J Steroid Biochem Mol Biol 43:335-41. 1992
    ..In fetal adrenal microsomes, 21-hydroxylation of progesterone to 11-desoxycorticosterone (DOC) and 11-desoxycortisol (DOCOL) was catalyzed...
  83. ncbi The role of zinc in pre- and postnatal mammalian thymic immunohistogenesis
    B Bodey
    Department of Pathology, School of Medicine, University of Southern California, Los Angeles, USA
    In Vivo 12:695-722. 1998
    ..marked involution, cortisone and progesterone administration have a slight to moderate effect while use of desoxycorticosterone has no effect...
  84. ncbi Influence of infusion of deoxycorticosterone acetate on the responses of kidney function elicited by stimulation of the peripheral arterial chemoreceptors with almitrine bismesylate in anaesthetized rats
    M Schmidt
    Institute of Physiology, Ernst Moritz Arndt University Greifswald, DDR
    Biomed Biochim Acta 46:1027-33. 1987
    ..25 mg/kg). The experiments were carried out in moderate osmotic diuresis. In one series desoxycorticosterone acetate (DOCA) was infused at a rate of 35-40 ng/min.100 g body weight...
  85. ncbi ["High pouch output" syndrome. Role of mineralocorticoid diagnosis after restorative proctocolectomy]
    F X Huber
    , Heidelberg
    Chirurg 72:1446-52. 2001
    ..Neither group of patients showed increased activity of free corticosterone and free cortisol. Only free 11-desoxycorticosterone was elevated in the group with 'high pouch output'...
  86. ncbi Hypertension and virilization caused by a unique desoxycorticosterone- and androgen-secreting adrenal adenoma
    D Soranno
    Department of Pediatrics, New York University Medical Center, NY 10016, USA
    J Pediatr Endocrinol Metab 12:215-20. 1999
    We describe a rare androgen and desoxycorticosterone (DOC)-secreting adrenal tumor in a non-Cushingoid 14 year-old Haitian girl with secondary amenorrhea, hypertension and virilization...
  87. pmc Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction
    Tomasz J Guzik
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30033, USA
    J Exp Med 204:2449-60. 2007
    ..hypertension and do not develop abnormalities of vascular function during angiotensin II infusion or desoxycorticosterone acetate (DOCA)-salt. Adoptive transfer of T, but not B, cells restored these abnormalities...
  88. pmc Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms' tumor
    Joseph T Azzarello
    Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Int J Clin Exp Pathol 3:147-55. 2009
    ..In addition to its ability to catalyze steroid hormones (including androgen, desoxycorticosterone, and progesterone) and involvement in prostaglandins metabolism, we suspect that AKR1C3 may function as a ..
  89. ncbi Regulation of mineralocorticoid secretion by the superfused fetal monkey adrenal gland: lack of stimulation of aldosterone by ACTH
    M Seron Ferre
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco 94143
    J Dev Physiol 13:33-6. 1990
    ..of fetal adrenal minces (n = 6) demonstrated that the fetal adrenal secretes aldosterone as well as desoxycorticosterone, 18 hydroxydesoxy corticosterone, and 18 hydroxycorticosterone...
  90. ncbi [Effect of hypophysin and desoxycorticosterone acetate on kidney function in 3-month-old calves]
    D Jankowiak
    Katedra Fizjologii Zwierzat Akademii Rolniczej, Szczecinie
    Pol Arch Weter 30:57-73. 1990
    ..breed at the age of 3 months. Clearance methods were used to examine the hypophysin (0.1 u V/kg) and desoxycorticosterone acetate (0...
  91. ncbi [Effects of hypophysin and desoxycorticosterone-21-acetate on renal function in calves in the neonatal period. I. Diuresis volume, glomerular filtration rate and urinary excretion of endogenous creatinine]
    D Jankowiak
    Katedra Fizjologii Zwierzat Akademii Rolniczej w Szczecinie
    Pol Arch Weter 29:43-51. 1989
    Experiments concerning the influence of hypophysin (0.1 vol. unit/kg) and desoxycorticosterone-21-acetate (0...
  92. ncbi Renal hypertensive angiopathy. Comparison between chronic NO suppression and DOCA-salt intoxication
    Y Xu
    INSERM U28, Paris, France
    Am J Hypertens 8:167-76. 1995
    NG-nitro-L-arginine methyl ester (L-NAME) and 11-desoxycorticosterone plus salt intake (DOCA-salt) hypertensive rat models were compared to study the possible involvement of model-specific factors in the development of renal angiopathy ..
  93. ncbi [Non-hypertensive desoxycorticosterone treatment enhances the progression of atherosclerosis in WHHL rabbit]
    N Villeneuve
    Institut de Recherches Servier, Suresnes
    Arch Mal Coeur Vaiss 88:1197-201. 1995
    ....
  94. ncbi Tadeus Reichstein, co-winner of the Nobel Prize for Physiology or Medicine: on the occasion of the 110th anniversary of his birth in Poland
    Andrzej Wincewicz
    Department of Medical and General Pathomorphology, Medical University of Bialystok, Waszyngtona 13, 15 269, Bialystok, Poland
    Hormones (Athens) 6:341-3. 2007
    ..It was Tadeus Reichstein who isolated and synthesized desoxycorticosterone, which still remains the drug of first choice in the treatment of Addison's disease...
  95. ncbi Simultaneous quantitation of seven endogenous C-21 adrenal steroids by liquid chromatography tandem mass spectrometry in human serum
    Valdemir Melechco Carvalho
    Fleury Medicine and Health, Av Gal Valdomiro de Lima, 508 São Paulo, SP, CEP 04344 070, Brazil
    J Chromatogr B Analyt Technol Biomed Life Sci 872:154-61. 2008
    ..of cortisol, cortisone, 11-desoxycortisol, 21-desoxycortisol, corticosterone, 17-hydroxyprogesterone and 11-desoxycorticosterone in human serum by on-line extraction and LC-MS/MS...
  96. ncbi [Fibrosing alveolitis in a 7-year-old girl with autoimmune hemolytic anemia and autoimmune hepatitis]
    K Paul

    Pneumologie 45:928-31. 1991
    ..Progression of the disease could be avoided during the past 6 months by intensifying the immunosuppressive prednisolone therapy...
  97. ncbi [Historical vision of shock]
    C Dosne Pasqualini
    Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires
    Medicina (B Aires) 58:337-40. 1998
    ..moreover, it was demonstrated that the administration of cortisone led to 40% survival of the animals while desoxycorticosterone had no effect...
  98. ncbi Neuronal responses to iontophoretically applied angiotensin II, losartan and aldosterone, as well as gustatory stimuli, in non-anesthetized control and desoxycorticosterone acetate-pretreated rats
    M C Mousseau
    CNRS URA 1860, College de France, Paris, France
    Regul Pept 66:51-4. 1996
    The neuronal mechanism of the sodium appetite initiated in rats by priming with a mineralocorticoid (desoxycorticosterone acetate (DOCA)) treatment and subsequent central angiotensin II (Ang II) was investigated using electrophysiological-..
  99. ncbi Calcium carbonate exacerbates glomerular capillary hypertension and injury in rats with desoxycorticosterone-salt hypertension
    L D Dworkin
    Department of Medicine, New York University Medical Center, New York 10016
    Am J Hypertens 3:444-50. 1990
    ..on systemic and renal hemodynamics and glomerular injury in experimental hypertension, rats with desoxycorticosterone-salt hypertension were fed either standard chow, containing 1% calcium by weight, or chow supplemented with ..
  100. ncbi Marinobufagenin is an upstream modulator of Gadd45a stress signaling in preeclampsia
    Mohammad N Uddin
    Division of Nephrology and Hypertension, Department of Medicine, Texas A and M Health Science Center College of Medicine and Scott and White Memorial Hospital, Temple, TX 76508, USA
    Biochim Biophys Acta 1812:49-58. 2011
    ..These were: normal pregnant (NP, n=8); pregnant rats which received weekly injections of desoxycorticosterone acetate and 0...
  101. ncbi Glomerular expression of endothelial nitric oxide synthase in deoxycorticosterone acetate-salt-treated rats
    K Tsuchiya
    Department of Medicine, Kidney Center Tokyo Women s Medical University, Japan
    Clin Exp Pharmacol Physiol 27:818-20. 2000
    ..and mRNA expression was detected by reverse transcription-polymerase chain reaction (RT-PCR) in desoxycorticosterone acetate (DOCA)-salt-treated rats. 2...

Research Grants37

  1. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  2. EICOSANOIDS, VASCULAR TONE AND BLOOD PRESSURE
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..Blood pressure will also be measured in WT, TG or KO mice made hypertensive with desoxycorticosterone acetate/1% sodium chloride (DOCA-salt), angiotensin II or a NO synthase inhibitor...
  3. Role of H,K-ATPase in the Action of Mineralocorticoids
    Charles S Wingo; Fiscal Year: 2013
    ..Aldosterone and desoxycorticosterone (DOC) are mineralocorticoids that cause hypertension through increased urinary sodium (Na) retention and ..
  4. STEROIDS IN ADRENAL REGENERATION HYPERTENSION
    Celso Gomez Sanchez; Fiscal Year: 1980
    We have recently isolated 19-nor-desoxycorticosterone from the urine of rats with adrenal regeneration hypertension...
  5. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2008
    ..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. [unreadable] [unreadable] [unreadable]..
  6. Paraventricular Nucleus Signaling Mechanisms in Hypertension
    CARRIE NORTHCOTT; Fiscal Year: 2008
    ..In addition, due to the integrative nature of the PVN, these data will also provide a glimpse at the role of signaling in other physiological conditions, such as obesity. ..
  7. ROS and NO interaction in the PVN during hypertension?
    CARRIE NORTHCOTT; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2009
    ..abstract_text> ..
  9. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..Consequently, it will identify another component (Ac-SDKP) as part of the multiple mediators participating in the cardioprotective effects of ACEi in hypertension. ..
  10. Mechanisms of altered venous tone in hypertension
    ALEX PEREZ RIVERA; Fiscal Year: 2005
    ..Answers to these questions will provide a basic understanding of venous function that could lead to better pharmacological approaches not only for hypertension treatment but also for any disease in which there is a vein dysfunction. ..
  11. Genetic Determinants of Sodium Retention
    John Pratt; Fiscal Year: 2006
    ..In summary, by exploring candidate sites for increased Na retention in blacks in comparison to whites, we seek to identify new mechanisms for common forms of hypertension. ..
  12. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2002
    ..Data obtained from these specific aims will permit the understanding of the molecular determinant responsible for synaptic plasticity in CNS. ..
  13. Endothelin Actions on Vascular Function in Hypertension
    RALPH WATSON; Fiscal Year: 2007
    ..Could this lead to the development of a new class of ET-1 receptor antagonists for the treatment of salt-sensitive HT and the prevention of vascular complications of HT? ..
  14. Epithelial Na channel (ENaC) polymorphisms in hyptertention
    James Stockand; Fiscal Year: 2007
    ..Preliminary results support the feasibility of this investigation and suggest that this line of inquiry will yield significant and novel findings. [unreadable] [unreadable]..
  15. Tissue Kallikrein, Oxidative Stress and Renal Fibrosis
    Julie Chao; Fiscal Year: 2007
    ..abstract_text> ..
  16. KALLISTATIN IN HYPERTENSION
    Julie Chao; Fiscal Year: 2008
    ..abstract_text> ..
  17. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 2001
    ..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
  18. RENAL TRANSPORT OF NONELECTROLYTES, SALT AND WATER
    James Schafer; Fiscal Year: 2002
    ..These observations will provide important information regarding the physiological or pathophysiological circumstances under which AVP would contribute to salt retention. ..
  19. Progesterone regulation of human luteal cell viability
    John Peluso; Fiscal Year: 2006
    ..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. [unreadable] [unreadable]..
  20. Low-Renin Hypertension in African Americans
    John Pratt; Fiscal Year: 2003
    ..In summary, we explore unique but simple approaches to treatment of low-renin hypertension in blacks, a treatment modality that could prove useful to many patients currently with uncontrolled blood pressure. ..
  21. Fusion Proteins As Probes of P450 Structure and Function
    Richard Auchus; Fiscal Year: 2004
    ..In addition, this approach might be generally applicable to structural studies of membrane-bound proteins. ..
  22. FOREBRAIN AND HINDBRAIN MECHANISMS OF SALT APPETITE
    ROBERT THUNHORST; Fiscal Year: 2005
    ....
  23. CENTRAL GUSTATORY ELECTROPHYSIOLOGY IN MICE
    Stuart McCaughey; Fiscal Year: 2005
    ..abstract_text> ..
  24. SELECTIVE ANESTHETIC ACTIONS ON NMDA RECEPTORS
    Hugh Criswell; Fiscal Year: 2002
    ..This Aim will verify experimentally, the correlational data from Specific Aims I and II. ..
  25. Stoichiometry and modular retrieval of ENaC
    James Stockand; Fiscal Year: 2009
    ..This research will provide critical insight about the molecualr architecture of ENaC and regulation of this important channel. ..
  26. ENDOTHELIN AND NEURAL CONTROL OF VEINS IN HYPERTENSION
    Gregory Fink; Fiscal Year: 2002
    ..abstract_text> ..
  27. Humoral Interactions in long-term blood pressure control
    VIRGINIA BROOKS; Fiscal Year: 2005
    ..abstract_text> ..
  28. NEUROPEPTIDES AND CARDIOVASCULAR REGULATION
    VIRGINIA BROOKS; Fiscal Year: 2002
    ....
  29. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2003
    ..Data obtained from these specific aims will permit the understanding of the molecular determinant responsible for synaptic plasticity in CNS possibly relevant o for the understanding of neuropsychiatric disorders. ..
  30. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2008
    ..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
  31. Experimental approaches to understanding the ENS and its disorders
    James Galligan; Fiscal Year: 2006
    ..This will help the attendees develop a network of professional contacts who can help the young investigator in the career development process. [unreadable] [unreadable]..
  32. Regulation of Oocyte Viability by Granulosa Cell Contact
    John Peluso; Fiscal Year: 2004
    ..abstract_text> ..
  33. Protein Kinase G Regulation of Granulosa Cell Viability
    John Peluso; Fiscal Year: 2006
    ..We now propose to test this hypothesis using biochemical, genetic, imaging and cell biological techniques. [unreadable] [unreadable]..
  34. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  35. Neurosteroids: Relevance to Cortical Development
    A Grobin; Fiscal Year: 2007
    ..These studies could represent a model of the role of neurosteroid on stress in brain development. ..
  36. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  37. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..