- Global strategy for asthma management and prevention: GINA executive summary
E D Bateman
University of Cape Town Lung Institute, PO Box 34560, Groote School, 7700 Mowbray, Cape Town, South Africa
Eur Respir J 31:143-78. 2008
..The importance of the patient-care giver partnership and guided self-management, along with setting goals for treatment, are also emphasised...
- COPD exacerbations: defining their cause and prevention
Jadwiga A Wedzicha
Academic Unit of Respiratory Medicine, Royal Free and University College Medical School University College London, UK
Lancet 370:786-96. 2007
- Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study
Critical Care Center, Hospital de Sabadell, CIBER Enfermedades Respiratorias, Universidad Autonoma de Barcelona, Sabadell, Spain
Am J Respir Crit Care Med 180:861-6. 2009
..Several Surviving Sepsis Campaign Guidelines recommendations are reevaluated...
- Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis
Department of Medicine, Wake Forest University School of Medicine, One Medical Center Boulevard, Winston Salem, NC 27157, USA
Arch Intern Med 169:219-29. 2009
..We aimed to ascertain the risk of pneumonia with long-term inhaled corticosteroid use among patients with chronic obstructive pulmonary disease (COPD)...
- The pathophysiology and treatment of sepsis
Richard S Hotchkiss
Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
N Engl J Med 348:138-50. 2003
- Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase
Peter J Barnes
Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
Lancet 363:731-3. 2004
..This hypothesis raises the possibility that novel therapeutic approaches might unlock this corticosteroid resistance, leading to more effective anti-inflammatory treatments for COPD and other severe inflammatory diseases...
- Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
Prescott G Woodruff
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 104:15858-63. 2007
- Corticosteroid effectiveness in IgA nephropathy: long-term results of a randomized, controlled trial
Department of Nephrology and Dialysis, A Manzoni Hospital, Lecco, Italy
J Am Soc Nephrol 15:157-63. 2004
..The histologic picture and proteinuria during early and late follow-up improve the prediction of outcome, but considerable variability remains outside the model...
- Internet-based self-management plus education compared with usual care in asthma: a randomized trial
Victor van der Meer
Leiden University Medical Center, Leiden, The Netherlands
Ann Intern Med 151:110-20. 2009
..The Internet may support patient self-management of chronic conditions, such as asthma...
- Temporal clustering of exacerbations in chronic obstructive pulmonary disease
John R Hurst
Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, London, United Kingdom
Am J Respir Crit Care Med 179:369-74. 2009
..We hypothesized that exacerbations may cluster together in time, a finding that would have important implications for targeting preventative interventions and the analysis of clinical trial data...
- Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma
Department of Pediatrics, Copenhagen University Hospital, DK 2920 Gentofte, Copenhagen, Denmark
Am J Respir Crit Care Med 171:315-22. 2005
..027) compared with placebo. Montelukast effectively reduced asthma exacerbations in 2- to 5-year-old patients with intermittent asthma over 12 months of treatment and was generally well tolerated...
- Pathogenesis and natural history of osteonecrosis
Division of Rheumatology, Allergy and Clinical Immunology, Department of Radiology, University of California at Davis, Davis, CA 95616, USA
Semin Arthritis Rheum 32:94-124. 2002
..The goal of this article is to review data extensively in the medical literature with respect to the pathogenesis of osteonecrosis, its natural history, and treatment...
- Roflumilast with long-acting β2-agonists for COPD: influence of exacerbation history
E D Bateman
University of Cape Town Lung Institute, Cape Town, South Africa
Eur Respir J 38:553-60. 2011
..No differences arose in adverse events between these subgroups. Roflumilast may be used to reduce exacerbations and improve dyspnoea and lung function, without increasing adverse events in COPD patients receiving concomitant LABAs...
- Subacromial ultrasound guided or systemic steroid injection for rotator cuff disease: randomised double blind study
Ole M Ekeberg
Department of Physical Medicine and Rehabilitation, Ullevål University Hospital and Medical Faculty, University of Oslo, 0407 Oslo, Norway
BMJ 338:a3112. 2009
..To compare the effectiveness of ultrasound guided corticosteroid injection in the subacromial bursa with systemic corticosteroid injection in patients with rotator cuff disease...
- Preterm birth and inhaled corticosteroid use in 6- to 19-year-olds: a Swedish national cohort study
Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
Pediatrics 127:1052-9. 2011
..In this study, we examined the risk of asthma in a national cohort of schoolchildren grouped according to degree of immaturity expressed as completed gestational weeks at birth...
- Exacerbations of chronic obstructive pulmonary disease
Jadwiga A Wedzicha
Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Dominion House, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
Respir Care 48:1204-13; discussion 1213-5. 2003
..Antibiotics have some efficacy in treating exacerbations. Exacerbation frequency increases with progressive airflow obstruction; so patients with chronic respiratory failure are particularly susceptible to exacerbation...
- Limited agreement between current and long-term asthma control in children: the PACMAN cohort study
Ellen S Koster
Division of Pharmacoepidemiology and Clinical Pharmacotherapy, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Pediatr Allergy Immunol 22:776-83. 2011
..To assess predictors of asthma control, we need firm outcome phenotypes. The aim of this study was to investigate the association between measurements of current and long-term asthma control...
- Shared treatment decision making improves adherence and outcomes in poorly controlled asthma
Sandra R Wilson
Palo Alto Medical Foundation Research Institute, CA 94301, USA
Am J Respir Crit Care Med 181:566-77. 2010
..Poor adherence to asthma controller medications results in poor treatment outcomes...
- Weekly self-monitoring and treatment adjustment benefit patients with partly controlled and uncontrolled asthma: an analysis of the SMASHING study
Victor van der Meer
Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
Respir Res 11:74. 2010
..We hypothesized that self-management guided by weekly monitoring of asthma control tailors pharmacological therapy to individual needs and improves asthma control for patients with partly controlled or uncontrolled asthma...
- Diagnosis and management of alcoholic liver disease
Arthur J McCullough
Department of Gastroenterology and Hepatology and The Digestive Disease Institute and the Cleveland Clinic Lerner College of Medicine at Case Western University, Cleveland, Ohio 44195, USA
J Dig Dis 12:257-62. 2011
..Patients with endstage liver disease should be considered for liver transplantation. Six months of abstinence is considered to be a requirement prior to transplant, but this length of time may be adjusted in individual bases...
- Effect of immunomodulatory therapies in patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia
Department of Infectious Diseases, Hospital Universitari de Bellvitge, University of Barcelona, Feixa Llarga s n, Barcelona, Spain
J Infect 62:193-9. 2011
..To determine the effect of immunomodulatory therapies on the development of severe disease in hospitalized adults with laboratory-confirmed pandemic influenza A (H1N1) 2009 complicated by pneumonia...
- The effect of corticosteroids usage on bacterial killing, clearance and nerve damage in leprosy; part 3--Study of two comparable groups of 100 multibacillary (MB) patients each, treated with MDT + steroids vs. MDT alone, assessed at 6 months post-release
Vanaja Prabhakar Shetty
The Foundation for Medical Research, 84 A, R G Thadani Marg, Worli, Mumbai 400 018, India
Lepr Rev 81:41-58. 2010
..To investigate effects of therapeutic usage of corticosteroids on M. leprae killing and clearance, on clearance of granuloma and on nerve damage in multibacillary (MB) leprosy patients...
- Monocyte response to LPS after exposure to corticosteroids and chloroquine with implications for systemic lupus erythematosus
A M Cepika
Department of Pediatrics, Children s Hospital Zagreb, Klaiceva 16, Zagreb, Croatia
Scand J Immunol 72:434-43. 2010
..Therefore, even if low-dose steroids or chloroquine do not seem to affect TLR4 expression and signalling, steroids might decrease cytokine production in response to LPS...
- Asthma symptoms and medication in the PIAMA birth cohort: evidence for under and overtreatment
Department of Pediatrics Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands
Pediatr Allergy Immunol 22:652-9. 2011
..Our aim was to investigate whether inhaled medication use in young children was in agreement with asthma symptoms at the age of 2-8 yr...
- Neurosarcoidosis: a study of 30 new cases
F G Joseph
Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1LE, UK
J Neurol Neurosurg Psychiatry 80:297-304. 2009
..The male preponderance is of interest particularly considering the female predominance of systemic sarcoidosis...
- Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection
R A M Breen
Department of Thoracic and HIV Medicine, Royal Free Hospital, London NW3 2QG, UK
Thorax 59:704-7. 2004
..It has been suggested that deterioration of tuberculosis (TB) during appropriate treatment, termed a paradoxical reaction (PR), is more common and severe in HIV positive individuals on highly active antiretroviral therapy (HAART)...
- Inhaled corticosteroids and risk of pneumonia in newly diagnosed COPD
Min J Joo
Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
Respir Med 104:246-52. 2010
..Little is known of this risk in newly diagnosed COPD patients. The objective of this study was to determine if the use of ICS among newly diagnosed COPD patients is associated with an increased risk of pneumonia hospitalizations...
- The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology
Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Pediatrics, University of Padua, Padua, Italy
Allergy 62:857-71. 2007
..The creation of national and European databases is expected to generate better-quality data and help develop a stepwise approach for a better management of paediatric anaphylaxis...
- Distribution of receptor targets in the lung
Peter J Barnes
Department of Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
Proc Am Thorac Soc 1:345-51. 2004
..Many novel receptors, including orphan receptors, have now been identified as these may be future targets for developing novel therapies for asthma and chronic obstructive pulmonary disease...
- Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling
Femke L Groeneweg
Department of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden University Medical Centre, Leiden University, Einsteinweg 55, Leiden, The Netherlands
Mol Cell Endocrinol 350:299-309. 2012
..How do MR and GR translocate to the membrane and what are their downstream signalling partners? In this review we discuss these issues based on insights obtained from related receptors, most notably the estrogen receptor α...
- Regular use of inhaled corticosteroids and the long term prevention of hospitalisation for asthma
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Canada
Thorax 57:880-4. 2002
..Inhaled corticosteroids are effective at preventing asthma morbidity and mortality. Most studies, however, have focused on short term effects, raising uncertainty about their effectiveness in the long term...
- Adrenocortical cell lines
William E Rainey
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9032, USA
Mol Cell Endocrinol 228:23-38. 2004
..The current review will discuss the attributes and limitations of the currently available adrenocortical cell lines as models for adrenal studies...
- Exhaled nitric oxide predicts lung function decline in difficult-to-treat asthma
I H van Veen
Dept of Pulmonology, Medisch Spectrum Twente, Postbus 50000, 7500 KA Enschede, The Netherlands
Eur Respir J 32:344-9. 2008
..1 (95% CI, 1.7-3.4). Exhaled nitric oxide is a predictor of accelerated decline in lung function in patients with difficult-to-treat asthma, particularly if forced expiratory volume in one second is still normal...
- Evaluation of indirect biomarkers for detecting corticosteroids used as illegal growth promoters in beef cattle
Department of Histopathology, Istituto Zooprofilattico Sperimentale delle Venzie, Via dell Università 10, 35020 Legnaro, Padova, Italy
Vet Rec 163:147-51. 2008
..The samples that were positive by chemical analysis had cortisol concentrations of less than 2.0 ng/ml, whereas the mean cortisol concentration of the negative samples was 10.3 ng/ml...
- Withdrawal of inhaled corticosteroids in people with COPD in primary care: a randomised controlled trial
Aklak B Choudhury
Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, 2 Newark Street, London, E1 2AT, UK
Respir Res 8:93. 2007
..Most COPD patients are managed in primary care and receive ICS long-term and irrespective of severity. The effect of withdrawing ICS from COPD patients in primary care is unknown...
- Overall asthma control: the relationship between current control and future risk
Eric D Bateman
Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
J Allergy Clin Immunol 125:600-8, 608.e1-608.e6. 2010
..Asthma guidelines emphasize both maintaining current control and reducing future risk, but the relationship between these 2 targets is not well understood...
- Clinical practice. Gout
Robert A Terkeltaub
Rheumatology Section, Department of Medicine, San Diego Veterans Affairs Medical Center and the University of California San Diego School of Medicine, San Diego, CA 92161, USA
N Engl J Med 349:1647-55. 2003
- Report on the 124th ENMC International Workshop. Treatment of Duchenne muscular dystrophy; defining the gold standards of management in the use of corticosteroids. 2-4 April 2004, Naarden, The Netherlands
Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne NE3 4YQ, UK
Neuromuscul Disord 14:526-34. 2004
- High-dose inhaled corticosteroids versus add-on long-acting beta-agonists in asthma: an observational study
Department of General Practice and Primary Care, University of Aberdeen, Aberdeen, United Kingdom
J Allergy Clin Immunol 123:116-121.e10. 2009
..Controversy persists about the best option in routine practice...
- A porcine model of acute quadriplegic myopathy: a feasibility study
Department of Clinical Neurophysiology, Uppsala University, Sweden
Acta Anaesthesiol Scand 50:1058-67. 2006
..Accordingly, there is a need for relevant experimental animal models aimed at identifying underlying mechanisms...
- Restoring production of hippocampal neurons in old age
H A Cameron
Laboratory of Molecular Biology, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Neurosci 2:894-7. 1999
..The findings further suggest that decreased neurogenesis may contribute to age-related memory deficits associated with high corticosteroids, and that these deficits may be reversible...
- Carpal tunnel syndrome
Department of Surgery, Level 2, Belfast HSC Trust, Lisburn Road, Belfast BT9 7AB, United Kingdom
Ulster Med J 77:6-17. 2008
..Apart from early recovery and return to work there is no significant difference in terms of early and late complications and long-term pain relief between endoscopic and open carpal tunnel surgery...
- Nephropathy in IgG4-related systemic disease
Simon J W Watson
Nephrology, Renal Unit, Queen Margaret Hospital, Whitefield Road, Dunfermline KY12 0SU, UK
Am J Surg Pathol 30:1472-7. 2006
- Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
James C Hogg
University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
Am J Respir Crit Care Med 176:454-9. 2007
..COPD is associated with reduced life expectancy...
- Corticosteroid injections for painful shoulder: a meta-analysis
Department of General Practice and Primary Health Care, Faculty of Medical and Health Sciences, University of Auckland, PB 92019, Auckland, New Zealand
Br J Gen Pract 55:224-8. 2005
..There are no systematic reviews of corticosteroids for shoulder pain that calculate the numbers needed to treat...
- Review article: remission rates achievable by current therapies for inflammatory bowel disease
INSERM U954 and Department of Hepato Gastroenterology, University Hospital of Nancy, Henri Poincare University, Vandœuvre lès Nancy, France
Aliment Pharmacol Ther 33:870-9. 2011
..New medical therapies have improved outlook in inflammatory bowel disease but published impact on surgical rates has been modest suggesting that many patients are still not attaining remission...
- Budesonide/formoterol for maintenance and reliever therapy of asthma: a meta analysis of randomised controlled trials
S J Edwards
Outcomes Research, AstraZeneca UK Ltd, Luton, UK
Int J Clin Pract 64:619-27. 2010
- Clinical course of intestinal Behcet's disease during the first five years
Yoon Suk Jung
Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul, Korea
Dig Dis Sci 58:496-503. 2013
..We aimed to evaluate the clinical course of intestinal BD during the first 5 years after diagnosis, and to identify factors that could predict the 5-year clinical course...
- COPD, bone metabolism, and osteoporosis
Respiratory Division, Center of Metabolic Bone Diseases, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
Chest 139:648-57. 2011
..As long as intervention studies focusing on the bone in COPD are lacking, a more rigorous application of existing treatment guidelines of osteoporosis in general is mandatory...
- Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma
R J Meijer
Department of Pulmonary Diseases, University Hospital Groningen, Groningen, The Netherlands
Clin Exp Allergy 32:1096-103. 2002
..Several markers of inflammation like eosinophils and eosinophil cationic protein (ECP), as well as exhaled nitric oxide (NO), are good candidates to predict clinical response...
- Randomized controlled trial of adherence with single or combination inhaled corticosteroid/long-acting beta-agonist inhaler therapy in asthma
Medical Research Institute of New Zealand, Wellington, New Zealand
J Allergy Clin Immunol 126:505-10. 2010
..The inhaled corticosteroid (ICS)/long-acting beta-agonist (LABA) combination inhaler has the potential to improve adherence with ICS therapy in asthma...
- Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma
Raed A Dweik
Department of Pulmonary, Allergy, and Critical Care Medicine Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Respir Crit Care Med 181:1033-41. 2010
..Here, we hypothesized that classification of severe asthma based on airway inflammation as defined by Fe(NO) levels would identify a more reactive, at-risk asthma phenotype...
- Exacerbations of chronic obstructive pulmonary disease
South Texas Veterans Health Care System, Audie L Murphy Division, University of Texas Health Science Center, 7400 Merton Minter Boulevard, San Antonio, TX 78229, USA
Proc Am Thorac Soc 4:554-64. 2007
..We summarize the current literature, with special emphasis on the assessment of the long-term impact of this condition...
- Current trends in the pharmacotherapy of diabetic retinopathy
Department of Pharmacology, Ocular Laboratory, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, New Delhi, India
J Postgrad Med 58:132-9. 2012
..Method- Literature search was done on online database, Pubmed, Google Scholar, clinitrials.gov and browsing through individual ophthalmology journals and leading pharmaceutical company websites...
- Efficacy of tocilizumab in two patients with anti-TNF-alpha refractory uveitis
Ophthalmology Department, University Hospital, Dijon, France
Ocul Immunol Inflamm 19:382-3. 2011
..To report on two patients with refractory uveitis treated with tocilizumab; a new humanized monoclonal antibody against the interleukin-6 receptor (IL-6R)...
- A mobile telephone-based interactive self-care system improves asthma control
W T Liu
Dept of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
Eur Respir J 37:310-7. 2011
..The mobile telephone-based interactive self-care system provides a convenient and practical self-monitoring and -management of asthma, and improves asthma control...
- Second-generation corticosteroids for the treatment of Crohn's disease and ulcerative colitis: more effective and less side effects?
Chiara De Cassan
IBD Center, Milan, Italy
Dig Dis 30:368-75. 2012
- Refill adherence by the elderly for asthma/chronic obstructive pulmonary disease drugs dispensed over a 10-year period
Department of Pharmacy, Uppsala University, Uppsala, Sweden
J Clin Pharm Ther 32:603-11. 2007
..The objective was to survey prescription refill adherence for preventive asthma/chronic obstructive pulmonary disease (COPD) medication dispensed to patients 60 years and older over a 10-year period...
- Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial
Stanley J Szefler
National Jewish Health, Denver, CO, USA
Lancet 372:1065-72. 2008
- Long-term treatment with fluticasone propionate/salmeterol via Diskus improves asthma control versus fluticasone propionate alone
Rohit K Katial
National Jewish Health, Denver, Colorado, USA
Allergy Asthma Proc 32:127-36. 2011
..In addition, FSC 250/50 micrograms-treated subjects experienced fewer severe asthma exacerbations than subjects treated with FP 250 micrograms...
- Allergic rhinitis and inflammatory airway disease: interactions within the unified airspace
Bradley F Marple
Department of Otolaryngology Head and Neck Surgery, UT Southwestern Medical Center at Dallas, Dallas, Texas 75390 9035, USA
Am J Rhinol Allergy 24:249-54. 2010
- Etiology and management of pyoderma gangrenosum: a comprehensive review
Department of Dermatology, University of California, San Francisco, 94115, USA
Am J Clin Dermatol 13:191-211. 2012
..Here, we review the clinical presentation and pathophysiology of PG, as well as its associated conditions, diagnostic work-up, and management...
- New targets for drug development in asthma
Ian M Adcock
Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
Lancet 372:1073-87. 2008
..Although a cure is unlikely to be developed in the near future, a greater understanding of disease mechanisms could bring such a situation nearer to reality...
- Impact of a short-term educational intervention on adherence to asthma treatment and on asthma control
Paulo de Tarso Roth Dalcin
Department of Internal Medicine, Universidade Federal do Rio Grande do Sul UFRGS, Federal University of Rio Grande do Sul School of Medicine, Porto Alegre, Brazil
J Bras Pneumol 37:19-27. 2011
..To evaluate the effect of a short-term individualized education program on adherence to asthma treatment, inhalation techniques, and asthma control...
- The transient value of classifying preschool wheeze into episodic viral wheeze and multiple trigger wheeze
School of Paediatric and Child Health, University of Western Australia, Perth, WA, Australia
Acta Paediatr 99:56-60. 2010
..A recently proposed method for classifying preschool wheeze is to describe it as either episodic (viral) wheeze or multiple trigger wheeze. In research studies, phenotype is generally determined by retrospective questionnaire...
- Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence
L Keoki Williams
Center for Health Services Research, Henry Ford Health System, Detroit, MI 48202, USA
J Allergy Clin Immunol 128:1185-1191.e2. 2011
..Asthma is an inflammatory condition often punctuated by episodic symptomatic worsening, and accordingly, patients with asthma might have waxing and waning adherence to controller therapy...
- Respiratory medicines for children: current evidence, unlicensed use and research priorities
A R Smyth
University of Nottingham Division of Child Health, Queens Medical Centre, Nottingham, NG7 2UH, UK
Eur Respir J 35:247-65. 2010
- Eosinophilic airway inflammation in COPD
Institute for Lung Health, University Hospitals of Leicester, Leicester, UK
Int J Chron Obstruct Pulmon Dis 1:39-47. 2006
..Whether controlling eosinophilic inflammation in COPD patients with an airway eosinophilia will modify disease progression and possibly alter mortality is unknown, but warrants further investigation...
- Asthma: defining of the persistent adult phenotypes
Sally E Wenzel
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Lancet 368:804-13. 2006
..This Review analyses some of the methods that have been used to define asthma phenotypes and proposes an integrated method of classification to improve our understanding of these phenotypes...
- Corticosteroid insufficiency in acutely ill patients
Mark S Cooper
Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
N Engl J Med 348:727-34. 2003
- Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis
Christopher R Sudfeld
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, 6th Floor, Baltimore, MD 21205, United States
J Cyst Fibros 9:110-6. 2010
..Filamentous fungi are frequently recovered from respiratory cultures of individuals with CF...
- Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease
Johannes M A Daniels
Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Am J Respir Crit Care Med 181:150-7. 2010
..The role of antibiotics in acute exacerbations is controversial and their efficacy when added to systemic corticosteroids is unknown...
- Clinical manifestations of cerebral amyloid angiopathy-related inflammation
Jessica A Eng
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Ann Neurol 55:250-6. 2004
..These data add to evidence that inflammation against A beta can cause vascular dysfunction, a potential mechanism for the toxic response recently observed in clinical trials of A beta immunization...
- Dose-response relationship of inhaled corticosteroids and cataracts: a systematic review and meta-analysis
University of Otago, Otago, New Zealand
Respirology 14:983-90. 2009
..The aim of this study was to determine the dose-response relationship of ICS use and risk of cataracts in adults...
- The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release
Department of Haematology and Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
J Mol Biol 380:244-51. 2008
..The change in the hormone binding affinity results from a change in the flexibility or plasticity of the connecting loop, which modulates the configuration of the binding site...
- Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up
Department of Orthopaedic Surgery, St Elisabeth Hospital, Tilburg, The Netherlands
Am J Sports Med 39:1200-8. 2011
..Platelet-rich plasma (PRP) has been shown to be a general stimulation for repair and 1-year results showed promising success percentages...
- Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma
National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
Thorax 63:784-90. 2008
- Prolonged protection of the new inhaled corticosteroid fluticasone furoate against AMP hyperresponsiveness in patients with asthma
M van den Berge
Department of Pulmonary Diseases, University Medical Center Groningen, The Netherlands
Allergy 65:1531-5. 2010
..The aim of this study was to evaluate the efficacy and duration of action of a single dose of FF by studying protection against AHR to adenosine 5'-monophosphate (AMP) and effects on exhaled nitric oxide (eNO)...
- Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry
Division of Asthma, King s College London, Guy s, Campus, Great Maze Pond, London SE1 9RT, UK
Crit Care 14:R102. 2010
- Management of severe asthma in children
Imperial School of Medicine, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
Lancet 376:814-25. 2010
..However, despite the interest in innovative approaches, getting the basics right in children with apparently severe asthma will remain the foundation of management for the foreseeable future...
- Clinical practice. The incidentally discovered adrenal mass
William F Young
Division of Endocrinology, Diabetes, Metabolism, Nutrition, and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
N Engl J Med 356:601-10. 2007
- Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regime
Genentech, Inc, South San Francisco, Calif 94080, USA
J Allergy Clin Immunol 124:895-902.e1-4. 2009
..Identification of patients at risk for asthma exacerbations can assist physicians in addressing disease management and improve asthma-related health outcomes...
- Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study
Eric D Bateman
UCT Lung Institute, P O Box 34560, Groote Schuur 7937, Cape Town, South Africa
Am J Respir Crit Care Med 170:836-44. 2004
..07-0.27 per patient per year) and improvement in health status were significantly better with salmeterol/fluticasone. This study confirms that the goal of guideline-derived asthma control was achieved in a majority of the patients...
- Combination therapy of prednisone and ACE inhibitor versus ACE-inhibitor therapy alone in patients with IgA nephropathy: a randomized controlled trial
Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, No 8 Xishiku Street, Xicheng District, Beijing, People s Republic of China
Am J Kidney Dis 53:26-32. 2009
..In this study, we aim to investigate whether the addition of steroids to ACE-inhibitor therapy produces a more potent antiproteinuric effect and better protection of kidney function than an ACE inhibitor alone...
- Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids
J C Virchow
Department of Pneumology, University Medical Clinic Freiburg, Germany and AstraZeneca Pharmaceuticals, Macclesfield, United Kingdom
Am J Respir Crit Care Med 162:578-85. 2000
- Potential adverse effects of the inhaled corticosteroids
H William Kelly
Department of Pediatrics, University of New Mexico Children s Hospital, ACC Building 3rd Floor, 2211 Lomas Boulevard NE, Albuquerque, NM 87131 5311, USA
J Allergy Clin Immunol 112:469-78; quiz 479. 2003
..The data are insufficient to determine whether there is an effect on attainment of predicted adult height. The ICSs affect bone mineral density and risk of fractures in a dose-dependent fashion that appears significant at high doses...
- Exhaled leukotrienes and prostaglandins in COPD
Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
Thorax 58:585-8. 2003
- Atopic dermatitis in children in the United States, 1997-2004: visit trends, patient and provider characteristics, and prescribing patterns
Kimberly A Horii
Section of Dermatology, Children s Mercy Hospitals and Clinics, 2401 Gillham Rd, Kansas City, MO 64108, USA
Pediatrics 120:e527-34. 2007
- COPD: management of acute exacerbations and chronic stable disease
M H Hunter
Department of Family Medicine, Medical University of South Carolina College of Medicine, Charleston, USA
Am Fam Physician 64:603-12. 2001
..Influenza and pneumococcal vaccines should be given. Patients who do not respond to standard therapies may benefit from surgery...
- ANCA-associated vasculitis: diagnostic and therapeutic strategy
Division of Rheumatology and Allergy, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
Allergol Int 56:87-96. 2007
..This article describes the diagnostic criteria and the recent evidence-based therapeutic strategy of AAV...
- Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial
Kellie E Murphy
Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Lancet 372:2143-51. 2008
..We aimed to find out whether multiple courses of antenatal corticosteroids would reduce neonatal morbidity and mortality without adversely affecting fetal growth...
- Pharmacology of acute lung injury
Department of Medicine, Keio University School of Medicine, Tokyo, Japan
Pulm Pharmacol Ther 15:83-95. 2002
..Replacements of anticoagulation mediators have also suggested beneficial effects on the patient outcome. This article provides an overview of pharmacological treatments of ALI/ARDS...
- Severe strongyloidiasis in corticosteroid-treated patients: case series and literature review
Hopital Saint Antoine, Internal Medicine, Parasitology and Intensive Care Department, 184 rue du Fbg Saint Antoine, 75012 Paris, France
J Infect 54:18-27. 2007
..To describe the main features of severe strongyloidiasis in corticosteroid-treated patients..
- Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma
Kelan G Tantisira
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Pharmacogenet Genomics 18:733-7. 2008
..Additional pharmacogenetic investigations into regions of chromosomal diversity, including copy number variation and inversions, are warranted...
- Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD
Woo J Kim
Department of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea
Respirology 14:260-3. 2009
..This study investigated the association between the change in lung function in response to inhaled corticosteroids and single-nucleotide CRHR1 polymorphisms in patients with COPD...
- Intranasal corticosteroids and adrenal suppression
Francesca Maria Bruni
Department of Pediatrics, Policlinico G B Rossi, Verona, Italy
Neuroimmunomodulation 16:353-62. 2009
- Corticosteroid treatment in critically ill patients with pandemic influenza A/H1N1 2009 infection: analytic strategy using propensity scores
Sung Han Kim
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
Am J Respir Crit Care Med 183:1207-14. 2011
..Administration of adjuvant corticosteroids to patients with pandemic influenza A/H1N1 2009 (pH1N1) may reduce inflammation and improve outcomes...
- Clinical practice. Atopic dermatitis
Hywel C Williams
Center of Evidence Based Dermatology, Queen s Medical Center, University of Nottingham, Nottingham, United Kingdom
N Engl J Med 352:2314-24. 2005
- Pharmacologic immunosuppression
Neal R Barshes
Michael E DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin Suite 1628, Houston, TX 77030, USA
Front Biosci 9:411-20. 2004
..Ideally, medications would inducing graft tolerance while avoiding generalized immunosuppression and non-immunologic adverse effects. Future research will likely focus on molecular- and gene-level mechanisms to achieve this goal...
- Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis
John Victor Peter
Department of Medical Intensive Care, Christian Medical College and Hospital, Vellore, India 632 004
BMJ 336:1006-9. 2008
..To systematically review the efficacy of steroids in the prevention of acute respiratory distress syndrome (ARDS) in critically ill adults, and treatment for established ARDS...
- Corticosteroid resistance in airway disease
Peter J Barnes
National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
Proc Am Thorac Soc 1:264-8. 2004