adrenal cortex hormones

Summary

Top Publications

  1. ncbi Global strategy for asthma management and prevention: GINA executive summary
    E D Bateman
    University of Cape Town Lung Institute, PO Box 34560, Groote School, 7700 Mowbray, Cape Town, South Africa
    Eur Respir J 31:143-78. 2008
  2. ncbi COPD exacerbations: defining their cause and prevention
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School University College London, UK
    Lancet 370:786-96. 2007
  3. ncbi Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study
    Ricard Ferrer
    Critical Care Center, Hospital de Sabadell, CIBER Enfermedades Respiratorias, Universidad Autonoma de Barcelona, Sabadell, Spain
    Am J Respir Crit Care Med 180:861-6. 2009
  4. ncbi Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis
    Sonal Singh
    Department of Medicine, Wake Forest University School of Medicine, One Medical Center Boulevard, Winston Salem, NC 27157, USA
    Arch Intern Med 169:219-29. 2009
  5. ncbi The pathophysiology and treatment of sepsis
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 348:138-50. 2003
  6. ncbi Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase
    Peter J Barnes
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Lancet 363:731-3. 2004
  7. pmc Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15858-63. 2007
  8. ncbi Corticosteroid effectiveness in IgA nephropathy: long-term results of a randomized, controlled trial
    Claudio Pozzi
    Department of Nephrology and Dialysis, A Manzoni Hospital, Lecco, Italy
    J Am Soc Nephrol 15:157-63. 2004
  9. ncbi Internet-based self-management plus education compared with usual care in asthma: a randomized trial
    Victor van der Meer
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:110-20. 2009
  10. ncbi Temporal clustering of exacerbations in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, London, United Kingdom
    Am J Respir Crit Care Med 179:369-74. 2009

Research Grants

  1. 2006 Clinical Research Training Institute
    James George; Fiscal Year: 2006
  2. Clinical Research Training Institute
    James George; Fiscal Year: 2005
  3. INHALED STEROID ADHERENCE IN MODERATE & SEVERE ASTHMA
    Andrea Apter; Fiscal Year: 2004
  4. Individualized Interventions to Improve Asthma Adherence
    Andrea Apter; Fiscal Year: 2009
  5. Adherence & Treatment Outcome in Adolescents in CAMPCS
    Bruce Bender; Fiscal Year: 2003
  6. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2008
  7. Mechanisms of Steroid Resistance in Severe Asthma
    William Calhoun; Fiscal Year: 2005
  8. ASTHMA CLINICAL RESEARCH NETWORK
    William Calhoun; Fiscal Year: 2008
  9. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2008
  10. HIPPOCAMPAL FUNCTION DURING CORTICOSTEROID THERAPY
    E Sherwood Brown; Fiscal Year: 2004

Detail Information

Publications343 found, 100 shown here

  1. ncbi Global strategy for asthma management and prevention: GINA executive summary
    E D Bateman
    University of Cape Town Lung Institute, PO Box 34560, Groote School, 7700 Mowbray, Cape Town, South Africa
    Eur Respir J 31:143-78. 2008
    ..The importance of the patient-care giver partnership and guided self-management, along with setting goals for treatment, are also emphasised...
  2. ncbi COPD exacerbations: defining their cause and prevention
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School University College London, UK
    Lancet 370:786-96. 2007
    ....
  3. ncbi Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study
    Ricard Ferrer
    Critical Care Center, Hospital de Sabadell, CIBER Enfermedades Respiratorias, Universidad Autonoma de Barcelona, Sabadell, Spain
    Am J Respir Crit Care Med 180:861-6. 2009
    ..Several Surviving Sepsis Campaign Guidelines recommendations are reevaluated...
  4. ncbi Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis
    Sonal Singh
    Department of Medicine, Wake Forest University School of Medicine, One Medical Center Boulevard, Winston Salem, NC 27157, USA
    Arch Intern Med 169:219-29. 2009
    ..We aimed to ascertain the risk of pneumonia with long-term inhaled corticosteroid use among patients with chronic obstructive pulmonary disease (COPD)...
  5. ncbi The pathophysiology and treatment of sepsis
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 348:138-50. 2003
  6. ncbi Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase
    Peter J Barnes
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Lancet 363:731-3. 2004
    ..This hypothesis raises the possibility that novel therapeutic approaches might unlock this corticosteroid resistance, leading to more effective anti-inflammatory treatments for COPD and other severe inflammatory diseases...
  7. pmc Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:15858-63. 2007
    ....
  8. ncbi Corticosteroid effectiveness in IgA nephropathy: long-term results of a randomized, controlled trial
    Claudio Pozzi
    Department of Nephrology and Dialysis, A Manzoni Hospital, Lecco, Italy
    J Am Soc Nephrol 15:157-63. 2004
    ..The histologic picture and proteinuria during early and late follow-up improve the prediction of outcome, but considerable variability remains outside the model...
  9. ncbi Internet-based self-management plus education compared with usual care in asthma: a randomized trial
    Victor van der Meer
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:110-20. 2009
    ..The Internet may support patient self-management of chronic conditions, such as asthma...
  10. ncbi Temporal clustering of exacerbations in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, London, United Kingdom
    Am J Respir Crit Care Med 179:369-74. 2009
    ..We hypothesized that exacerbations may cluster together in time, a finding that would have important implications for targeting preventative interventions and the analysis of clinical trial data...
  11. ncbi Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma
    Hans Bisgaard
    Department of Pediatrics, Copenhagen University Hospital, DK 2920 Gentofte, Copenhagen, Denmark
    Am J Respir Crit Care Med 171:315-22. 2005
    ..027) compared with placebo. Montelukast effectively reduced asthma exacerbations in 2- to 5-year-old patients with intermittent asthma over 12 months of treatment and was generally well tolerated...
  12. ncbi Pathogenesis and natural history of osteonecrosis
    Yehudith Assouline-Dayan
    Division of Rheumatology, Allergy and Clinical Immunology, Department of Radiology, University of California at Davis, Davis, CA 95616, USA
    Semin Arthritis Rheum 32:94-124. 2002
    ..The goal of this article is to review data extensively in the medical literature with respect to the pathogenesis of osteonecrosis, its natural history, and treatment...
  13. ncbi Roflumilast with long-acting β2-agonists for COPD: influence of exacerbation history
    E D Bateman
    University of Cape Town Lung Institute, Cape Town, South Africa
    Eur Respir J 38:553-60. 2011
    ..No differences arose in adverse events between these subgroups. Roflumilast may be used to reduce exacerbations and improve dyspnoea and lung function, without increasing adverse events in COPD patients receiving concomitant LABAs...
  14. pmc Subacromial ultrasound guided or systemic steroid injection for rotator cuff disease: randomised double blind study
    Ole M Ekeberg
    Department of Physical Medicine and Rehabilitation, Ullevål University Hospital and Medical Faculty, University of Oslo, 0407 Oslo, Norway
    BMJ 338:a3112. 2009
    ..To compare the effectiveness of ultrasound guided corticosteroid injection in the subacromial bursa with systemic corticosteroid injection in patients with rotator cuff disease...
  15. ncbi Preterm birth and inhaled corticosteroid use in 6- to 19-year-olds: a Swedish national cohort study
    Hartmut Vogt
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatrics 127:1052-9. 2011
    ..In this study, we examined the risk of asthma in a national cohort of schoolchildren grouped according to degree of immaturity expressed as completed gestational weeks at birth...
  16. ncbi Exacerbations of chronic obstructive pulmonary disease
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, Dominion House, St Bartholomew s Hospital, London EC1A 7BE, United Kingdom
    Respir Care 48:1204-13; discussion 1213-5. 2003
    ..Antibiotics have some efficacy in treating exacerbations. Exacerbation frequency increases with progressive airflow obstruction; so patients with chronic respiratory failure are particularly susceptible to exacerbation...
  17. ncbi Limited agreement between current and long-term asthma control in children: the PACMAN cohort study
    Ellen S Koster
    Division of Pharmacoepidemiology and Clinical Pharmacotherapy, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Pediatr Allergy Immunol 22:776-83. 2011
    ..To assess predictors of asthma control, we need firm outcome phenotypes. The aim of this study was to investigate the association between measurements of current and long-term asthma control...
  18. pmc Shared treatment decision making improves adherence and outcomes in poorly controlled asthma
    Sandra R Wilson
    Palo Alto Medical Foundation Research Institute, CA 94301, USA
    Am J Respir Crit Care Med 181:566-77. 2010
    ..Poor adherence to asthma controller medications results in poor treatment outcomes...
  19. pmc Weekly self-monitoring and treatment adjustment benefit patients with partly controlled and uncontrolled asthma: an analysis of the SMASHING study
    Victor van der Meer
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 11:74. 2010
    ..We hypothesized that self-management guided by weekly monitoring of asthma control tailors pharmacological therapy to individual needs and improves asthma control for patients with partly controlled or uncontrolled asthma...
  20. ncbi Diagnosis and management of alcoholic liver disease
    Arthur J McCullough
    Department of Gastroenterology and Hepatology and The Digestive Disease Institute and the Cleveland Clinic Lerner College of Medicine at Case Western University, Cleveland, Ohio 44195, USA
    J Dig Dis 12:257-62. 2011
    ..Patients with endstage liver disease should be considered for liver transplantation. Six months of abstinence is considered to be a requirement prior to transplant, but this length of time may be adjusted in individual bases...
  21. ncbi Effect of immunomodulatory therapies in patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia
    Diego Viasus
    Department of Infectious Diseases, Hospital Universitari de Bellvitge, University of Barcelona, Feixa Llarga s n, Barcelona, Spain
    J Infect 62:193-9. 2011
    ..To determine the effect of immunomodulatory therapies on the development of severe disease in hospitalized adults with laboratory-confirmed pandemic influenza A (H1N1) 2009 complicated by pneumonia...
  22. ncbi The effect of corticosteroids usage on bacterial killing, clearance and nerve damage in leprosy; part 3--Study of two comparable groups of 100 multibacillary (MB) patients each, treated with MDT + steroids vs. MDT alone, assessed at 6 months post-release
    Vanaja Prabhakar Shetty
    The Foundation for Medical Research, 84 A, R G Thadani Marg, Worli, Mumbai 400 018, India
    Lepr Rev 81:41-58. 2010
    ..To investigate effects of therapeutic usage of corticosteroids on M. leprae killing and clearance, on clearance of granuloma and on nerve damage in multibacillary (MB) leprosy patients...
  23. ncbi Monocyte response to LPS after exposure to corticosteroids and chloroquine with implications for systemic lupus erythematosus
    A M Cepika
    Department of Pediatrics, Children s Hospital Zagreb, Klaiceva 16, Zagreb, Croatia
    Scand J Immunol 72:434-43. 2010
    ..Therefore, even if low-dose steroids or chloroquine do not seem to affect TLR4 expression and signalling, steroids might decrease cytokine production in response to LPS...
  24. ncbi Asthma symptoms and medication in the PIAMA birth cohort: evidence for under and overtreatment
    Daan Caudri
    Department of Pediatrics Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands
    Pediatr Allergy Immunol 22:652-9. 2011
    ..Our aim was to investigate whether inhaled medication use in young children was in agreement with asthma symptoms at the age of 2-8 yr...
  25. ncbi Neurosarcoidosis: a study of 30 new cases
    F G Joseph
    Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1LE, UK
    J Neurol Neurosurg Psychiatry 80:297-304. 2009
    ..The male preponderance is of interest particularly considering the female predominance of systemic sarcoidosis...
  26. pmc Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection
    R A M Breen
    Department of Thoracic and HIV Medicine, Royal Free Hospital, London NW3 2QG, UK
    Thorax 59:704-7. 2004
    ..It has been suggested that deterioration of tuberculosis (TB) during appropriate treatment, termed a paradoxical reaction (PR), is more common and severe in HIV positive individuals on highly active antiretroviral therapy (HAART)...
  27. ncbi Inhaled corticosteroids and risk of pneumonia in newly diagnosed COPD
    Min J Joo
    Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Respir Med 104:246-52. 2010
    ..Little is known of this risk in newly diagnosed COPD patients. The objective of this study was to determine if the use of ICS among newly diagnosed COPD patients is associated with an increased risk of pneumonia hospitalizations...
  28. ncbi The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology
    A Muraro
    Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Pediatrics, University of Padua, Padua, Italy
    Allergy 62:857-71. 2007
    ..The creation of national and European databases is expected to generate better-quality data and help develop a stepwise approach for a better management of paediatric anaphylaxis...
  29. ncbi Distribution of receptor targets in the lung
    Peter J Barnes
    Department of Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Proc Am Thorac Soc 1:345-51. 2004
    ..Many novel receptors, including orphan receptors, have now been identified as these may be future targets for developing novel therapies for asthma and chronic obstructive pulmonary disease...
  30. ncbi Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling
    Femke L Groeneweg
    Department of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research, Leiden University Medical Centre, Leiden University, Einsteinweg 55, Leiden, The Netherlands
    Mol Cell Endocrinol 350:299-309. 2012
    ..How do MR and GR translocate to the membrane and what are their downstream signalling partners? In this review we discuss these issues based on insights obtained from related receptors, most notably the estrogen receptor α...
  31. pmc Regular use of inhaled corticosteroids and the long term prevention of hospitalisation for asthma
    S Suissa
    Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Canada
    Thorax 57:880-4. 2002
    ..Inhaled corticosteroids are effective at preventing asthma morbidity and mortality. Most studies, however, have focused on short term effects, raising uncertainty about their effectiveness in the long term...
  32. ncbi Adrenocortical cell lines
    William E Rainey
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9032, USA
    Mol Cell Endocrinol 228:23-38. 2004
    ..The current review will discuss the attributes and limitations of the currently available adrenocortical cell lines as models for adrenal studies...
  33. ncbi Exhaled nitric oxide predicts lung function decline in difficult-to-treat asthma
    I H van Veen
    Dept of Pulmonology, Medisch Spectrum Twente, Postbus 50000, 7500 KA Enschede, The Netherlands
    Eur Respir J 32:344-9. 2008
    ..1 (95% CI, 1.7-3.4). Exhaled nitric oxide is a predictor of accelerated decline in lung function in patients with difficult-to-treat asthma, particularly if forced expiratory volume in one second is still normal...
  34. ncbi Evaluation of indirect biomarkers for detecting corticosteroids used as illegal growth promoters in beef cattle
    M Vascellari
    Department of Histopathology, Istituto Zooprofilattico Sperimentale delle Venzie, Via dell Università 10, 35020 Legnaro, Padova, Italy
    Vet Rec 163:147-51. 2008
    ..The samples that were positive by chemical analysis had cortisol concentrations of less than 2.0 ng/ml, whereas the mean cortisol concentration of the negative samples was 10.3 ng/ml...
  35. pmc Withdrawal of inhaled corticosteroids in people with COPD in primary care: a randomised controlled trial
    Aklak B Choudhury
    Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, 2 Newark Street, London, E1 2AT, UK
    Respir Res 8:93. 2007
    ..Most COPD patients are managed in primary care and receive ICS long-term and irrespective of severity. The effect of withdrawing ICS from COPD patients in primary care is unknown...
  36. ncbi Overall asthma control: the relationship between current control and future risk
    Eric D Bateman
    Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    J Allergy Clin Immunol 125:600-8, 608.e1-608.e6. 2010
    ..Asthma guidelines emphasize both maintaining current control and reducing future risk, but the relationship between these 2 targets is not well understood...
  37. ncbi Clinical practice. Gout
    Robert A Terkeltaub
    Rheumatology Section, Department of Medicine, San Diego Veterans Affairs Medical Center and the University of California San Diego School of Medicine, San Diego, CA 92161, USA
    N Engl J Med 349:1647-55. 2003
  38. ncbi Report on the 124th ENMC International Workshop. Treatment of Duchenne muscular dystrophy; defining the gold standards of management in the use of corticosteroids. 2-4 April 2004, Naarden, The Netherlands
    K Bushby
    Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne NE3 4YQ, UK
    Neuromuscul Disord 14:526-34. 2004
  39. ncbi High-dose inhaled corticosteroids versus add-on long-acting beta-agonists in asthma: an observational study
    Mike Thomas
    Department of General Practice and Primary Care, University of Aberdeen, Aberdeen, United Kingdom
    J Allergy Clin Immunol 123:116-121.e10. 2009
    ..Controversy persists about the best option in routine practice...
  40. ncbi A porcine model of acute quadriplegic myopathy: a feasibility study
    H Norman
    Department of Clinical Neurophysiology, Uppsala University, Sweden
    Acta Anaesthesiol Scand 50:1058-67. 2006
    ..Accordingly, there is a need for relevant experimental animal models aimed at identifying underlying mechanisms...
  41. ncbi Restoring production of hippocampal neurons in old age
    H A Cameron
    Laboratory of Molecular Biology, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Neurosci 2:894-7. 1999
    ..The findings further suggest that decreased neurogenesis may contribute to age-related memory deficits associated with high corticosteroids, and that these deficits may be reversible...
  42. pmc Carpal tunnel syndrome
    Somaiah Aroori
    Department of Surgery, Level 2, Belfast HSC Trust, Lisburn Road, Belfast BT9 7AB, United Kingdom
    Ulster Med J 77:6-17. 2008
    ..Apart from early recovery and return to work there is no significant difference in terms of early and late complications and long-term pain relief between endoscopic and open carpal tunnel surgery...
  43. ncbi Nephropathy in IgG4-related systemic disease
    Simon J W Watson
    Nephrology, Renal Unit, Queen Margaret Hospital, Whitefield Road, Dunfermline KY12 0SU, UK
    Am J Surg Pathol 30:1472-7. 2006
    ....
  44. pmc Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
    James C Hogg
    University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Am J Respir Crit Care Med 176:454-9. 2007
    ..COPD is associated with reduced life expectancy...
  45. pmc Corticosteroid injections for painful shoulder: a meta-analysis
    Bruce Arroll
    Department of General Practice and Primary Health Care, Faculty of Medical and Health Sciences, University of Auckland, PB 92019, Auckland, New Zealand
    Br J Gen Pract 55:224-8. 2005
    ..There are no systematic reviews of corticosteroids for shoulder pain that calculate the numbers needed to treat...
  46. ncbi Review article: remission rates achievable by current therapies for inflammatory bowel disease
    L Peyrin-Biroulet
    INSERM U954 and Department of Hepato Gastroenterology, University Hospital of Nancy, Henri Poincare University, Vandœuvre lès Nancy, France
    Aliment Pharmacol Ther 33:870-9. 2011
    ..New medical therapies have improved outlook in inflammatory bowel disease but published impact on surgical rates has been modest suggesting that many patients are still not attaining remission...
  47. ncbi Budesonide/formoterol for maintenance and reliever therapy of asthma: a meta analysis of randomised controlled trials
    S J Edwards
    Outcomes Research, AstraZeneca UK Ltd, Luton, UK
    Int J Clin Pract 64:619-27. 2010
    ....
  48. ncbi Clinical course of intestinal Behcet's disease during the first five years
    Yoon Suk Jung
    Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul, Korea
    Dig Dis Sci 58:496-503. 2013
    ..We aimed to evaluate the clinical course of intestinal BD during the first 5 years after diagnosis, and to identify factors that could predict the 5-year clinical course...
  49. ncbi COPD, bone metabolism, and osteoporosis
    An Lehouck
    Respiratory Division, Center of Metabolic Bone Diseases, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Chest 139:648-57. 2011
    ..As long as intervention studies focusing on the bone in COPD are lacking, a more rigorous application of existing treatment guidelines of osteoporosis in general is mandatory...
  50. ncbi Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma
    R J Meijer
    Department of Pulmonary Diseases, University Hospital Groningen, Groningen, The Netherlands
    Clin Exp Allergy 32:1096-103. 2002
    ..Several markers of inflammation like eosinophils and eosinophil cationic protein (ECP), as well as exhaled nitric oxide (NO), are good candidates to predict clinical response...
  51. ncbi Randomized controlled trial of adherence with single or combination inhaled corticosteroid/long-acting beta-agonist inhaler therapy in asthma
    Kyle Perrin
    Medical Research Institute of New Zealand, Wellington, New Zealand
    J Allergy Clin Immunol 126:505-10. 2010
    ..The inhaled corticosteroid (ICS)/long-acting beta-agonist (LABA) combination inhaler has the potential to improve adherence with ICS therapy in asthma...
  52. pmc Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma
    Raed A Dweik
    Department of Pulmonary, Allergy, and Critical Care Medicine Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 181:1033-41. 2010
    ..Here, we hypothesized that classification of severe asthma based on airway inflammation as defined by Fe(NO) levels would identify a more reactive, at-risk asthma phenotype...
  53. ncbi Exacerbations of chronic obstructive pulmonary disease
    Antonio Anzueto
    South Texas Veterans Health Care System, Audie L Murphy Division, University of Texas Health Science Center, 7400 Merton Minter Boulevard, San Antonio, TX 78229, USA
    Proc Am Thorac Soc 4:554-64. 2007
    ..We summarize the current literature, with special emphasis on the assessment of the long-term impact of this condition...
  54. ncbi Current trends in the pharmacotherapy of diabetic retinopathy
    B Kumar
    Department of Pharmacology, Ocular Laboratory, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, New Delhi, India
    J Postgrad Med 58:132-9. 2012
    ..Method- Literature search was done on online database, Pubmed, Google Scholar, clinitrials.gov and browsing through individual ophthalmology journals and leading pharmaceutical company websites...
  55. ncbi Efficacy of tocilizumab in two patients with anti-TNF-alpha refractory uveitis
    Aurore Muselier
    Ophthalmology Department, University Hospital, Dijon, France
    Ocul Immunol Inflamm 19:382-3. 2011
    ..To report on two patients with refractory uveitis treated with tocilizumab; a new humanized monoclonal antibody against the interleukin-6 receptor (IL-6R)...
  56. ncbi A mobile telephone-based interactive self-care system improves asthma control
    W T Liu
    Dept of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Eur Respir J 37:310-7. 2011
    ..The mobile telephone-based interactive self-care system provides a convenient and practical self-monitoring and -management of asthma, and improves asthma control...
  57. ncbi Second-generation corticosteroids for the treatment of Crohn's disease and ulcerative colitis: more effective and less side effects?
    Chiara De Cassan
    IBD Center, Milan, Italy
    Dig Dis 30:368-75. 2012
    ....
  58. ncbi Refill adherence by the elderly for asthma/chronic obstructive pulmonary disease drugs dispensed over a 10-year period
    K Krigsman
    Department of Pharmacy, Uppsala University, Uppsala, Sweden
    J Clin Pharm Ther 32:603-11. 2007
    ..The objective was to survey prescription refill adherence for preventive asthma/chronic obstructive pulmonary disease (COPD) medication dispensed to patients 60 years and older over a 10-year period...
  59. pmc Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial
    Stanley J Szefler
    National Jewish Health, Denver, CO, USA
    Lancet 372:1065-72. 2008
    ....
  60. ncbi Long-term treatment with fluticasone propionate/salmeterol via Diskus improves asthma control versus fluticasone propionate alone
    Rohit K Katial
    National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 32:127-36. 2011
    ..In addition, FSC 250/50 micrograms-treated subjects experienced fewer severe asthma exacerbations than subjects treated with FP 250 micrograms...
  61. ncbi Allergic rhinitis and inflammatory airway disease: interactions within the unified airspace
    Bradley F Marple
    Department of Otolaryngology Head and Neck Surgery, UT Southwestern Medical Center at Dallas, Dallas, Texas 75390 9035, USA
    Am J Rhinol Allergy 24:249-54. 2010
    ....
  62. ncbi Etiology and management of pyoderma gangrenosum: a comprehensive review
    Iris Ahronowitz
    Department of Dermatology, University of California, San Francisco, 94115, USA
    Am J Clin Dermatol 13:191-211. 2012
    ..Here, we review the clinical presentation and pathophysiology of PG, as well as its associated conditions, diagnostic work-up, and management...
  63. ncbi New targets for drug development in asthma
    Ian M Adcock
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Lancet 372:1073-87. 2008
    ..Although a cure is unlikely to be developed in the near future, a greater understanding of disease mechanisms could bring such a situation nearer to reality...
  64. ncbi Impact of a short-term educational intervention on adherence to asthma treatment and on asthma control
    Paulo de Tarso Roth Dalcin
    Department of Internal Medicine, Universidade Federal do Rio Grande do Sul UFRGS, Federal University of Rio Grande do Sul School of Medicine, Porto Alegre, Brazil
    J Bras Pneumol 37:19-27. 2011
    ..To evaluate the effect of a short-term individualized education program on adherence to asthma treatment, inhalation techniques, and asthma control...
  65. ncbi The transient value of classifying preschool wheeze into episodic viral wheeze and multiple trigger wheeze
    A Schultz
    School of Paediatric and Child Health, University of Western Australia, Perth, WA, Australia
    Acta Paediatr 99:56-60. 2010
    ..A recently proposed method for classifying preschool wheeze is to describe it as either episodic (viral) wheeze or multiple trigger wheeze. In research studies, phenotype is generally determined by retrospective questionnaire...
  66. pmc Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence
    L Keoki Williams
    Center for Health Services Research, Henry Ford Health System, Detroit, MI 48202, USA
    J Allergy Clin Immunol 128:1185-1191.e2. 2011
    ..Asthma is an inflammatory condition often punctuated by episodic symptomatic worsening, and accordingly, patients with asthma might have waxing and waning adherence to controller therapy...
  67. ncbi Respiratory medicines for children: current evidence, unlicensed use and research priorities
    A R Smyth
    University of Nottingham Division of Child Health, Queens Medical Centre, Nottingham, NG7 2UH, UK
    Eur Respir J 35:247-65. 2010
    ....
  68. pmc Eosinophilic airway inflammation in COPD
    Shironjit Saha
    Institute for Lung Health, University Hospitals of Leicester, Leicester, UK
    Int J Chron Obstruct Pulmon Dis 1:39-47. 2006
    ..Whether controlling eosinophilic inflammation in COPD patients with an airway eosinophilia will modify disease progression and possibly alter mortality is unknown, but warrants further investigation...
  69. ncbi Asthma: defining of the persistent adult phenotypes
    Sally E Wenzel
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Lancet 368:804-13. 2006
    ..This Review analyses some of the methods that have been used to define asthma phenotypes and proposes an integrated method of classification to improve our understanding of these phenotypes...
  70. ncbi Corticosteroid insufficiency in acutely ill patients
    Mark S Cooper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    N Engl J Med 348:727-34. 2003
  71. pmc Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis
    Christopher R Sudfeld
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, 6th Floor, Baltimore, MD 21205, United States
    J Cyst Fibros 9:110-6. 2010
    ..Filamentous fungi are frequently recovered from respiratory cultures of individuals with CF...
  72. ncbi Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease
    Johannes M A Daniels
    Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Am J Respir Crit Care Med 181:150-7. 2010
    ..The role of antibiotics in acute exacerbations is controversial and their efficacy when added to systemic corticosteroids is unknown...
  73. ncbi Clinical manifestations of cerebral amyloid angiopathy-related inflammation
    Jessica A Eng
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 55:250-6. 2004
    ..These data add to evidence that inflammation against A beta can cause vascular dysfunction, a potential mechanism for the toxic response recently observed in clinical trials of A beta immunization...
  74. ncbi Dose-response relationship of inhaled corticosteroids and cataracts: a systematic review and meta-analysis
    Mark Weatherall
    University of Otago, Otago, New Zealand
    Respirology 14:983-90. 2009
    ..The aim of this study was to determine the dose-response relationship of ICS use and risk of cataracts in adults...
  75. ncbi The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release
    Aiwu Zhou
    Department of Haematology and Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
    J Mol Biol 380:244-51. 2008
    ..The change in the hormone binding affinity results from a change in the flexibility or plasticity of the connecting loop, which modulates the configuration of the binding site...
  76. ncbi Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up
    Taco Gosens
    Department of Orthopaedic Surgery, St Elisabeth Hospital, Tilburg, The Netherlands
    Am J Sports Med 39:1200-8. 2011
    ..Platelet-rich plasma (PRP) has been shown to be a general stimulation for repair and 1-year results showed promising success percentages...
  77. ncbi Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma
    P Bhavsar
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 63:784-90. 2008
    ....
  78. ncbi Prolonged protection of the new inhaled corticosteroid fluticasone furoate against AMP hyperresponsiveness in patients with asthma
    M van den Berge
    Department of Pulmonary Diseases, University Medical Center Groningen, The Netherlands
    Allergy 65:1531-5. 2010
    ..The aim of this study was to evaluate the efficacy and duration of action of a single dose of FF by studying protection against AHR to adenosine 5'-monophosphate (AMP) and effects on exhaled nitric oxide (eNO)...
  79. pmc Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry
    Richard Beale
    Division of Asthma, King s College London, Guy s, Campus, Great Maze Pond, London SE1 9RT, UK
    Crit Care 14:R102. 2010
    ....
  80. pmc Management of severe asthma in children
    Andrew Bush
    Imperial School of Medicine, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Lancet 376:814-25. 2010
    ..However, despite the interest in innovative approaches, getting the basics right in children with apparently severe asthma will remain the foundation of management for the foreseeable future...
  81. ncbi Clinical practice. The incidentally discovered adrenal mass
    William F Young
    Division of Endocrinology, Diabetes, Metabolism, Nutrition, and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 356:601-10. 2007
  82. ncbi Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regime
    Tmirah Haselkorn
    Genentech, Inc, South San Francisco, Calif 94080, USA
    J Allergy Clin Immunol 124:895-902.e1-4. 2009
    ..Identification of patients at risk for asthma exacerbations can assist physicians in addressing disease management and improve asthma-related health outcomes...
  83. ncbi Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study
    Eric D Bateman
    UCT Lung Institute, P O Box 34560, Groote Schuur 7937, Cape Town, South Africa
    Am J Respir Crit Care Med 170:836-44. 2004
    ..07-0.27 per patient per year) and improvement in health status were significantly better with salmeterol/fluticasone. This study confirms that the goal of guideline-derived asthma control was achieved in a majority of the patients...
  84. ncbi Combination therapy of prednisone and ACE inhibitor versus ACE-inhibitor therapy alone in patients with IgA nephropathy: a randomized controlled trial
    Jicheng Lv
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, No 8 Xishiku Street, Xicheng District, Beijing, People s Republic of China
    Am J Kidney Dis 53:26-32. 2009
    ..In this study, we aim to investigate whether the addition of steroids to ACE-inhibitor therapy produces a more potent antiproteinuric effect and better protection of kidney function than an ACE inhibitor alone...
  85. ncbi Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids
    J C Virchow
    Department of Pneumology, University Medical Clinic Freiburg, Germany and AstraZeneca Pharmaceuticals, Macclesfield, United Kingdom
    Am J Respir Crit Care Med 162:578-85. 2000
    ....
  86. ncbi Potential adverse effects of the inhaled corticosteroids
    H William Kelly
    Department of Pediatrics, University of New Mexico Children s Hospital, ACC Building 3rd Floor, 2211 Lomas Boulevard NE, Albuquerque, NM 87131 5311, USA
    J Allergy Clin Immunol 112:469-78; quiz 479. 2003
    ..The data are insufficient to determine whether there is an effect on attainment of predicted adult height. The ICSs affect bone mineral density and risk of fractures in a dose-dependent fashion that appears significant at high doses...
  87. pmc Exhaled leukotrienes and prostaglandins in COPD
    P Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Thorax 58:585-8. 2003
    ....
  88. ncbi Atopic dermatitis in children in the United States, 1997-2004: visit trends, patient and provider characteristics, and prescribing patterns
    Kimberly A Horii
    Section of Dermatology, Children s Mercy Hospitals and Clinics, 2401 Gillham Rd, Kansas City, MO 64108, USA
    Pediatrics 120:e527-34. 2007
    ....
  89. ncbi COPD: management of acute exacerbations and chronic stable disease
    M H Hunter
    Department of Family Medicine, Medical University of South Carolina College of Medicine, Charleston, USA
    Am Fam Physician 64:603-12. 2001
    ..Influenza and pneumococcal vaccines should be given. Patients who do not respond to standard therapies may benefit from surgery...
  90. ncbi ANCA-associated vasculitis: diagnostic and therapeutic strategy
    Shoichi Ozaki
    Division of Rheumatology and Allergy, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    Allergol Int 56:87-96. 2007
    ..This article describes the diagnostic criteria and the recent evidence-based therapeutic strategy of AAV...
  91. ncbi Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial
    Kellie E Murphy
    Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Lancet 372:2143-51. 2008
    ..We aimed to find out whether multiple courses of antenatal corticosteroids would reduce neonatal morbidity and mortality without adversely affecting fetal growth...
  92. ncbi Pharmacology of acute lung injury
    Sadatomo Tasaka
    Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Pulm Pharmacol Ther 15:83-95. 2002
    ..Replacements of anticoagulation mediators have also suggested beneficial effects on the patient outcome. This article provides an overview of pharmacological treatments of ALI/ARDS...
  93. ncbi Severe strongyloidiasis in corticosteroid-treated patients: case series and literature review
    Laurence Fardet
    Hopital Saint Antoine, Internal Medicine, Parasitology and Intensive Care Department, 184 rue du Fbg Saint Antoine, 75012 Paris, France
    J Infect 54:18-27. 2007
    ..To describe the main features of severe strongyloidiasis in corticosteroid-treated patients..
  94. pmc Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma
    Kelan G Tantisira
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pharmacogenet Genomics 18:733-7. 2008
    ..Additional pharmacogenetic investigations into regions of chromosomal diversity, including copy number variation and inversions, are warranted...
  95. ncbi Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD
    Woo J Kim
    Department of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea
    Respirology 14:260-3. 2009
    ..This study investigated the association between the change in lung function in response to inhaled corticosteroids and single-nucleotide CRHR1 polymorphisms in patients with COPD...
  96. ncbi Intranasal corticosteroids and adrenal suppression
    Francesca Maria Bruni
    Department of Pediatrics, Policlinico G B Rossi, Verona, Italy
    Neuroimmunomodulation 16:353-62. 2009
    ....
  97. ncbi Corticosteroid treatment in critically ill patients with pandemic influenza A/H1N1 2009 infection: analytic strategy using propensity scores
    Sung Han Kim
    Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    Am J Respir Crit Care Med 183:1207-14. 2011
    ..Administration of adjuvant corticosteroids to patients with pandemic influenza A/H1N1 2009 (pH1N1) may reduce inflammation and improve outcomes...
  98. ncbi Clinical practice. Atopic dermatitis
    Hywel C Williams
    Center of Evidence Based Dermatology, Queen s Medical Center, University of Nottingham, Nottingham, United Kingdom
    N Engl J Med 352:2314-24. 2005
  99. ncbi Pharmacologic immunosuppression
    Neal R Barshes
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin Suite 1628, Houston, TX 77030, USA
    Front Biosci 9:411-20. 2004
    ..Ideally, medications would inducing graft tolerance while avoiding generalized immunosuppression and non-immunologic adverse effects. Future research will likely focus on molecular- and gene-level mechanisms to achieve this goal...
  100. pmc Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis
    John Victor Peter
    Department of Medical Intensive Care, Christian Medical College and Hospital, Vellore, India 632 004
    BMJ 336:1006-9. 2008
    ..To systematically review the efficacy of steroids in the prevention of acute respiratory distress syndrome (ARDS) in critically ill adults, and treatment for established ARDS...
  101. ncbi Corticosteroid resistance in airway disease
    Peter J Barnes
    National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Proc Am Thorac Soc 1:264-8. 2004
    ....

Research Grants74

  1. 2006 Clinical Research Training Institute
    James George; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  2. Clinical Research Training Institute
    James George; Fiscal Year: 2005
    ..It is through this near one to one ratio with the trainees that ASH intends to foster and sustain interest in clinical hematologic research and thereby help stimulate the career development of future clinical researchers in hematology. ..
  3. INHALED STEROID ADHERENCE IN MODERATE & SEVERE ASTHMA
    Andrea Apter; Fiscal Year: 2004
    ..Upon the foundation of my prior clinical experience and education, this training program is designed to equip me with the additional skills and research experience necessary to become a fully independent investigator. ..
  4. Individualized Interventions to Improve Asthma Adherence
    Andrea Apter; Fiscal Year: 2009
    ..We will estimate the incremental cost-effectiveness of PS. ..
  5. Adherence & Treatment Outcome in Adolescents in CAMPCS
    Bruce Bender; Fiscal Year: 2003
    ..abstract_text> ..
  6. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2008
    ..abstract_text> ..
  7. Mechanisms of Steroid Resistance in Severe Asthma
    William Calhoun; Fiscal Year: 2005
    ..abstract_text> ..
  8. ASTHMA CLINICAL RESEARCH NETWORK
    William Calhoun; Fiscal Year: 2008
    ..Pitt strongly supports collaborative, clinical network research. Data from the DART and ESTA trials can help to improve the care of patients with asthma. ..
  9. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2008
    ..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
  10. HIPPOCAMPAL FUNCTION DURING CORTICOSTEROID THERAPY
    E Sherwood Brown; Fiscal Year: 2004
    ..Through this award, the Pl will extend his previous research experience by adding new skills and knowledge which will be used for investigations at the interface of neuroscience and clinical research. ..
  11. Treating Asthma Patients with Major Depressive Disorder
    E Sherwood Brown; Fiscal Year: 2004
    ....
  12. Naltrexone for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2006
    ..Alcohol use is the primary outcome, and alcohol craving is the secondary outcome. Manic and depressive symptom severity and the relationship between changes in alcohol use and changes in mood will be expIored. ..
  13. THE CLINICAL EFFECTIVENESS OF PHARMACY ADHERENCE INFORMATION FOR DIABETES CONTROL
    Keoki Williams; Fiscal Year: 2010
    ..Analyses will control for cluster randomization effects. The introduction of sustainable medication adherence monitoring in clinical practice holds great potential to improve health outcomes among patients with diabetes. ..
  14. USING INFORMATION TECHNOLOGY TO IMPROVE ASTHMA ADHERENCE
    Keoki Williams; Fiscal Year: 2008
    ..abstract_text> ..
  15. Cognition and Affect in Children Treated with Steroids
    Christine Mrakotsky; Fiscal Year: 2005
    ..This cross-sectional study will lay the foundation to future longitudinal research on acute vs. chronic GC effects and provide vital information for neuropsychological intervention planning. ..
  16. Use of Automated Phone Calls to Promote Adherence with Inhaled Corticosteroids
    William Vollmer; Fiscal Year: 2009
    ..This method, if it helps people take their medications as prescribed, could be used with a variety of other long-term medical conditions. ..
  17. Promoting Adherence to Improve Effectiveness of Cardiovascular Disease Therapies
    WILLIAM MARION VOLLMER; Fiscal Year: 2010
    ..This research should also be broadly applicable to other diseases and treatments. ..
  18. Mechanism of Endotoxin's Effect On Allergy Risk
    Keoki Williams; Fiscal Year: 2008
    ..It is the hoped that understanding the mechanism of endotoxin's effect will establish new targets for the prevention of allergies. ..
  19. Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism
    Carlos Camargo; Fiscal Year: 2008
    ..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..
  20. Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children
    Carlos Camargo; Fiscal Year: 2008
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of asthma. [unreadable] [unreadable] [unreadable] [unreadable]..
  21. SCLERODERMA LUNG STUDY
    Donald Tashkin; Fiscal Year: 2003
    ..abstract_text> ..
  22. Improving Physician Adherence to Asthma Guidelines
    Gregory Diette; Fiscal Year: 2005
    ..usual generalist care; and 3) How care should be organized for management of chronic diseases. ..
  23. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Donald Tashkin; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate in this study. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  24. Pimecrolius on T cell Responses in Atopic March
    Jonathan Spergel; Fiscal Year: 2008
    ..In third aim of the trial, we explore the effects of pimecrolimus as a disease-modifying agent in the prevention of asthma. Asthma phenotype will be examined by spirometry per and post-beta-2-agonist and exhaled nitric oxide. ..
  25. FES for foot-drop in hemiparesis
    John Chae; Fiscal Year: 2009
    ..This proposed approach is expected to improve patient outcome and challenge the present clinical paradigm of prescribing AFOs for stroke survivors with foot-drop. ..
  26. ELECTROSTIMULATION FOR HEMIPLEGIA
    John Chae; Fiscal Year: 2004
    ..EMG-controlled NIMES may also be effective for lower extremity motor and functional recovery. ..
  27. Airway-Central Nervous System Control
    Richard Martin; Fiscal Year: 2008
    ..abstract_text> ..
  28. Brain Connections
    Michelle Petri; Fiscal Year: 2006
    ..abstract_text> ..
  29. Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage Function
    Anne Fitzpatrick; Fiscal Year: 2009
    ..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
  30. Nutritional and Hormonal Determinants of Peak Bone Mass
    Madhusmita Misra; Fiscal Year: 2008
    ..The effects of estrogen in weight recovered vs. non-weight recovered AN will also be studied. ..
  31. Genetic epidemiology of TLR4 alleles and bacteremia
    Jason Chien; Fiscal Year: 2006
    ..Ultimately, this cohort of patients will be developed in anticipation of future genetic discoveries in the complicated pathway of pathogen recognition and host inflammatory response. ..
  32. Novel treatment for muscle disease: Fueling the pipeline and finding the product
    ROBERT GRIGGS; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  33. Perinatal Regionalization and Quality of Care
    Scott Lorch; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  34. Cytokine Regulation of Growth Hormone Signaling
    LEE ARMISTEAD DENSON; Fiscal Year: 2010
    ..If the proposed studies support the utility of TNF blockade in reversing GH resistance in colitis, these findings should translate into improved clinical therapies for children with IBD. ..
  35. Dichlorphenamide vs Acetazolamide for Periodic Paralysis
    Robert C Griggs; Fiscal Year: 2010
    ..abstract_text> ..
  36. DISEASE MECHANISMS IN ASNHL AND ITS MOUSE MODEL
    Vincent K Tuohy; Fiscal Year: 2010
    ..abstract_text> ..
  37. Towards a better understanding of work-aggravated asthma
    Catherine Lemiere; Fiscal Year: 2009
    ..The occurrence of asthma exacerbations will be recorded. The economic impact of WAA will be assessed in terms of work disability and use of health resources and compared with OA and asthma without OA not WAA. ..
  38. DEVELOPMENTAL LUNG TOXICOLOGY & THE IMMATURE CLARA CELL
    Charles Plopper; Fiscal Year: 2009
    ..This work will further our understanding of the basic molecular mechanisms by which environmental insults are involved in the origins of lung diseases that begin in childhood. ..
  39. Interneuronal mechanisms for the control of walking
    Jianguo Cheng; Fiscal Year: 2009
    ....
  40. Respiratory Viruses and Airflow Obstruction after HCT
    Michael Boeckh; Fiscal Year: 2008
    ..These studies will improve our understanding of the interaction between respiratory viruses and late pulmonary complications after HCT, which will ultimately enable us to formulate more rational treatment strategies. ..
  41. Acute Effects of Diesel Exhaust in Asthmatic Children
    Toby Lewis; Fiscal Year: 2008
    ..They will also investigate associations between exhaled hydrogen a biomarker of asthma activity, and diesel exhaust exposure. [unreadable] [unreadable] [unreadable]..
  42. Maternal flu infection and brain development in primates
    Christopher L Coe; Fiscal Year: 2010
    ....
  43. Models and technologies for defining phenotype
    Eugene Bleecker; Fiscal Year: 2006
    ..A heavy emphasis will be placed on discussing, demonstrating, and where feasible performing approaches and techniques useful for characterization of "phenotype" ..
  44. 2004 National Vitiligo Foundation Scientific Conference
    Raymond Boissy; Fiscal Year: 2004
    ..In addition, mini-symposiums will be organized for each of the sessions. ..
  45. INHALED NO IN PREVENTION OF CHRONIC LUNG DISEASE
    Scott Lorch; Fiscal Year: 2004
    ..In summary, this clinical trial will assess the efficacy and safety of inhaled nitric oxide for amelioration of a major disease of premature infants. ..
  46. Proteomic and mRNA Profiling of Urine and Urine Sediment
    Brad Rovin; Fiscal Year: 2004
    ..abstract_text> ..
  47. ASSESSMENT MODE AND VALIDITY OF SELF-REPORTS IN CHILDREN
    Bruce Bender; Fiscal Year: 2004
    ..Results from this investigation are expected to have immediate and direct implication for clinical research in asthma and with other chronic conditions. ..
  48. IMMUNOPATHOGENESIS OF ALLERGIC ASPERGILLOSIS
    RAYMOND SLAVIN; Fiscal Year: 2003
    ..abstract_text> ..
  49. PHENOLS/CATECHOLS IN OCCUPATIONAL/CONTACT VITILIGO SKIN
    Raymond Boissy; Fiscal Year: 2002
    ....
  50. ON THE ROLE OF THE HPS GENE PRODUCT IN MELANOCYTES
    Raymond Boissy; Fiscal Year: 2002
    ..These studies will contribute to our knowledge of cellular trafficking in general and the pathophysiology of HPS in specific. ..
  51. CNS REMYELINATION BY GENETICALLY-MODIFIED T CELLS
    VINCENT TUOHY; Fiscal Year: 2002
    ..abstract_text> ..
  52. NEUROSCIENCE OF HIV CONFERENCE
    Joseph Berger; Fiscal Year: 2002
    ..Dr. Brian Wigdahl, international co-chair of the ISNV, is a co-investigator on this grant. ..
  53. Cytokine Regulation of Liver Growth Hormone Signaling
    Lee Denson; Fiscal Year: 2004
    ..These findings will have implications for therapeutic strategies to ameliorate acquired GH resistance in diseases complicated by liver inflammation, including chronic cholestatic liver diseases ..
  54. Nitric Oxide/Carbon Monoxide in Pulmonary Hypertention
    Raed Dweik; Fiscal Year: 2006
    ..The training component of this proposal will lead to the candidate's transition to a fully independent investigator. ..
  55. ANDROGEN PRODUCTION IN ADRENARCHE AND PCOS
    WALTER MILLER; Fiscal Year: 2006
    ..abstract_text> ..
  56. Thymosin beta 4 and Autoimmune Ocular Surface Disease
    Gabriel Sosne; Fiscal Year: 2004
    ..abstract_text> ..
  57. NEONATAL TRAINING GRANT
    Alan Jobe; Fiscal Year: 2005
    ..The goal for this training grant is to support only research training for Neonatologists who have the potential and motivation to become successful research oriented academic neonatologists. ..
  58. Plan forTrial to find Optimum Steroid Regimen in Duchenne Muscular Dystrophy
    ROBERT GRIGGS; Fiscal Year: 2006
    ....
  59. CELLULAR IMMUNOTHERAPY FOR HEMATOLOGIC MALIGNANCY
    John Levine; Fiscal Year: 2006
    ..2A. To evaluate a panel of cytokines as surrogate markers for GVHD and correlate these with clinical outcomes during the above trial. 2B. To correlate changes in minimal residual disease with clinical outcomes during the above trial. ..
  60. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
  61. Biomarkers of oxidative stress and inflammation in COPD
    William MacNee; Fiscal Year: 2005
    ..Such information will allow the identification of novel biomarkers and the fingerprints themselves may represent a mechanism to stratify COPD patients and allow the assessment of novel therapies. ..
  62. Thymosin beta 4 and Corneal Wound Healing
    Gabriel Sosne; Fiscal Year: 2005
    ..abstract_text> ..
  63. Jo-1-specific T Cell Responses in Polymyositis
    DANA ASCHERMAN; Fiscal Year: 2007
    ..These studies are intended to also provide insight concerning the relative roles of altered T cell repertoire and antigen presentation in the expression of Jo-1+ polymyositis. ..
  64. COMMUNITY PARTNERSHIP TO REDUCE ASTHMA DISPARITIES
    Elizabeth McQuaid; Fiscal Year: 2009
    ..A Sustainability Advisory board will provide guidance regarding project implementation in the community beyond the life of the grant. ..
  65. Phase II Study of 44Gy from 131I-81C6 for CNS Tumors
    David Reardon; Fiscal Year: 2004
    ..To further define the toxicity of this approach and Specific Aim 3.To determine the impact of this therapy on quality of life. ..
  66. TESTING INTERVENTIONS IN PEDIATRIC ASTHMA
    Elizabeth McQuaid; Fiscal Year: 2002
    ..Exploratory analyses will investigate mediators of behavior change. Results will be used to design a larger, randomized controlled trial comparing behavioral feedback to asthma education. ..
  67. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2008
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. [unreadable] [unreadable]..
  68. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  69. SunSmart America: Evaluating a School-based Curriculum
    Robert Kirsner; Fiscal Year: 2008
    ..The results will be used for planning to implement the SunSmart America curriculum throughout Florida and nationwide. [unreadable] [unreadable] [unreadable]..
  70. ROLE OF CONDITIONING IN THE PHARMACOTHERAPY OF PSORIASIS
    Robert Ader; Fiscal Year: 2004
    ....