hormones

Summary

Summary: Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.

Top Publications

  1. ncbi Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance
    Dana W Kolpin
    US Geological Survey, Iowa City, Iowa 52244, USA
    Environ Sci Technol 36:1202-11. 2002
  2. doi Skin and brain age together: The role of hormones in the ageing process
    Evgenia Makrantonaki
    Department of Dermatology, Dessau Medical Center, Germany
    Exp Gerontol 45:801-13. 2010
  3. ncbi Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study
    Henry A Feldman
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 87:589-98. 2002
  4. doi The influence of stress hormones on fear circuitry
    Sarina M Rodrigues
    Institute of Personality and Social Research, University of California, Berkeley, California 94720, USA
    Annu Rev Neurosci 32:289-313. 2009
  5. ncbi Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism
    Peter J Havel
    Department of Nutrition, University of California, Davis, Davis, California 95616, USA
    Diabetes 53:S143-51. 2004
  6. ncbi Cardiac hormones as diagnostic tools in heart failure
    Heikki Ruskoaho
    Department of Pharmacology and Toxicology, Biocenter Oulu, FIN 90014 University of Oulu, Finland
    Endocr Rev 24:341-56. 2003
  7. pmc MicroRNAs in body fluids--the mix of hormones and biomarkers
    Maria Angelica Cortez
    The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Rev Clin Oncol 8:467-77. 2011
  8. ncbi Hormonal responses and adaptations to resistance exercise and training
    William J Kraemer
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, 06269, USA
    Sports Med 35:339-61. 2005
  9. ncbi Stress hormones in mammals and birds: comparative aspects regarding metabolism, excretion, and noninvasive measurement in fecal samples
    R Palme
    Institute of Biochemistry, Department of Natural Sciences, University of Veterinary Medicine, Vienna, Austria
    Ann N Y Acad Sci 1040:162-71. 2005
  10. pmc Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise
    Scot R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 285:29027-32. 2010

Research Grants

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
  3. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
  4. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
  5. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
  6. SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016
  7. Sogol Mostoufi-Moab; Fiscal Year: 2016
  8. Yun Fai Chris Lau; Fiscal Year: 2014
  9. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
  10. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012

Detail Information

Publications442 found, 100 shown here

  1. ncbi Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance
    Dana W Kolpin
    US Geological Survey, Iowa City, Iowa 52244, USA
    Environ Sci Technol 36:1202-11. 2002
    To provide the first nationwide reconnaissance of the occurrence of pharmaceuticals, hormones, and other organic wastewater contaminants (OWCs) in water resources, the U.S...
  2. doi Skin and brain age together: The role of hormones in the ageing process
    Evgenia Makrantonaki
    Department of Dermatology, Dessau Medical Center, Germany
    Exp Gerontol 45:801-13. 2010
    ..ageing, these include the growth hormone/insulin-like growth factor-I axis (somatopause) and that of sexual hormones, namely estradiol (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulphate (..
  3. ncbi Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study
    Henry A Feldman
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 87:589-98. 2002
    ..cohort of men aged 40-70 yr at baseline, to establish normative age trends for serum level of T and related hormones in middle-aged men and to test whether general health status affected the age trends...
  4. doi The influence of stress hormones on fear circuitry
    Sarina M Rodrigues
    Institute of Personality and Social Research, University of California, Berkeley, California 94720, USA
    Annu Rev Neurosci 32:289-313. 2009
    ..These stress hormones, in turn, provide feedback to the brain and influence neural structures that control emotion and cognition...
  5. ncbi Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism
    Peter J Havel
    Department of Nutrition, University of California, Davis, Davis, California 95616, USA
    Diabetes 53:S143-51. 2004
    b>Hormones produced by adipose tissue play a critical role in the regulation of energy intake, energy expenditure, and lipid and carbohydrate metabolism...
  6. ncbi Cardiac hormones as diagnostic tools in heart failure
    Heikki Ruskoaho
    Department of Pharmacology and Toxicology, Biocenter Oulu, FIN 90014 University of Oulu, Finland
    Endocr Rev 24:341-56. 2003
    ..High levels of cardiac hormones identify those at greatest risk for future serious cardiovascular events...
  7. pmc MicroRNAs in body fluids--the mix of hormones and biomarkers
    Maria Angelica Cortez
    The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Rev Clin Oncol 8:467-77. 2011
    ..In addition, we explore the concept that miRNAs could function as hormones.
  8. ncbi Hormonal responses and adaptations to resistance exercise and training
    William J Kraemer
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, 06269, USA
    Sports Med 35:339-61. 2005
    ..Anabolic hormones such as testosterone and the superfamily of growth hormones (GH) have been shown to be elevated during 15-30 ..
  9. ncbi Stress hormones in mammals and birds: comparative aspects regarding metabolism, excretion, and noninvasive measurement in fecal samples
    R Palme
    Institute of Biochemistry, Department of Natural Sciences, University of Veterinary Medicine, Vienna, Austria
    Ann N Y Acad Sci 1040:162-71. 2005
    A multitude of endocrine mechanisms are involved in coping with challenges. Front-line hormones to overcome stressful situations are glucocorticoids (GCs) and catecholamines (CAs)...
  10. pmc Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise
    Scot R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 285:29027-32. 2010
    ..rates of protein synthesis and is controlled by numerous stimuli, including those arising from nutrients and hormones in the circulating blood, as well as from contraction-induced signaling within the tissue...
  11. doi Stress hormones and immune function
    Jeanette I Webster Marketon
    Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Cell Immunol 252:16-26. 2008
    ..20 years we have demonstrated both in animal models and in human studies that stress increases neuroendocrine hormones, particularly glucocorticoids and catecholamines but to some extent also prolactin, growth hormone and nerve ..
  12. doi Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors
    Mohan Singh
    Research Group in Molecular Oncology and Endocrinology, Department of Chemistry Biology, University of Quebec, Trois Rivieres, 3351, Boulevard des Forges, CP 500, Trois Rivieres, Quebec G8Y 5H7, Canada
    J Endocrinol 210:5-14. 2011
    ..Implantation is a very intricate process, which is controlled by a number of complex molecules like hormones, cytokines, and growth factors and their cross talk...
  13. ncbi Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care--correlations with food intake, metabolism, exercise capacity, and hormones
    Marita Fouladiun
    Surgical Metabolic Research Laboratory at Lundberg Laboratory for Cancer Research, Goteborg, Sweden
    Cancer 103:2189-98. 2005
    ....
  14. doi Changes in calcitropic hormones, bone markers and insulin-like growth factor I (IGF-I) during pregnancy and postpartum: a controlled cohort study
    U K Møller
    Department of Endocrinology and Internal Medicine, Aarhus University Hospital, and Department of Clinical Medicine, Faculty of Health Sciences, Aarhus University, Tage Hansens Gade 2, 8000, Aarhus C, Denmark
    Osteoporos Int 24:1307-20. 2013
    ..This population-based cohort study presents the physiological changes in biochemical indices of calcium homeostasis and bone metabolism during pregnancy and lactation..
  15. ncbi The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men
    John K Amory
    Department of Medicine, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA 98195, USA
    J Clin Endocrinol Metab 92:1659-65. 2007
    ..Dutasteride and finasteride are 5alpha-reductase inhibitors (5ARIs) that dramatically reduce serum levels of dihydrotestosterone (DHT)...
  16. ncbi Age, body mass index, race and other determinants of steroid hormone variability: the HERITAGE Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Eur J Endocrinol 145:1-9. 2001
    To investigate from the HERITAGE Family Study database, 13 steroid hormones (androstane-3alpha, 17beta-diol glucuronide, androsterone glucuronide, cortisol, dehydroepiandrosterone (DHEA), DHEA ester (DHEAE), DHEA sulfate (DHEAS), ..
  17. ncbi Effects of combined stress during intense training on cellular immunity, hormones and respiratory infections
    Danielle Gomez-Merino
    Department of Physiology, IMASSA, Bretigny sur Orge, France
    Neuroimmunomodulation 12:164-72. 2005
    ....
  18. ncbi A receptor in pituitary and hypothalamus that functions in growth hormone release
    A D Howard
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Science 273:974-7. 1996
    ..On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone...
  19. ncbi The effects of hormones on sex differences in infection: from genes to behavior
    S L Klein
    Department of Molecular Microbiology and Immunology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205 2179, USA
    Neurosci Biobehav Rev 24:627-38. 2000
    ..It is, however, becoming increasingly more apparent that in addition to affecting host immunity, sex steroid hormones alter genes and behaviors that influence susceptibility and resistance to infection...
  20. doi Influence of electromagnetic fields emitted by GSM-900 cellular telephones on the circadian patterns of gonadal, adrenal and pituitary hormones in men
    Yasmina Djeridane
    Faculte de Medecine Pierre et Marie Curie, Service de Biochimie Medicale et Biologie Moleculaire, INSERM U713, 75013, Paris, France
    Radiat Res 169:337-43. 2008
    ..Our data show that the 900 MHz EMF exposure, at least under our experimental conditions, does not appear to affect endocrine functions in men...
  21. doi A single exposure to social isolation in domestic piglets activates behavioural arousal, neuroendocrine stress hormones, and stress-related gene expression in the brain
    E Kanitz
    Research Unit Behavioural Physiology, Research Institute for the Biology of Farm Animals, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Physiol Behav 98:176-85. 2009
    ..The present results also suggest that psychosocial stress effects should be considered for the assessment of livestock handling practices with respect to health and welfare...
  22. pmc Influence of photoperiod on hormones, behavior, and immune function
    James C Walton
    Department of Neuroscience, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Front Neuroendocrinol 32:303-19. 2011
    ..Thus, melatonin is the fulcrum mediating redistribution of energetic investment among physiological processes to maximize fitness and survival...
  23. doi Sexual differentiation of human behavior: effects of prenatal and pubertal organizational hormones
    Sheri A Berenbaum
    Departments of Psychology and Pediatrics, The Pennsylvania State University, University Park, PA 16802, USA
    Front Neuroendocrinol 32:183-200. 2011
    A key question concerns the extent to which sexual differentiation of human behavior is influenced by sex hormones present during sensitive periods of development (organizational effects), as occurs in other mammalian species...
  24. pmc Epithelial Na+ channel (ENaC), hormones, and hypertension
    James K Bubien
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Biol Chem 285:23527-31. 2010
    ..ENaC can also be stimulated to conduct sodium by two hormones: aldosterone and insulin...
  25. doi Hormones as epigenetic signals in developmental programming
    Abigail L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Exp Physiol 94:607-25. 2009
    ..b>Hormones have an important role in these epigenetic modifications and can signal the type, severity and duration of the ..
  26. pmc Environmental endocrine disruption: an effects assessment and analysis
    T M Crisp
    U S Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC 20460, USA
    Environ Health Perspect 106:11-56. 1998
    ..Background information is presented on the field of endocrinology, the nature of hormones, and potential sites for endocrine disruption, with specific examples of chemicals affecting these sites...
  27. ncbi Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1
    R L Robker
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 12:924-40. 1998
    ..in granulosa cells by treatment with estradiol or FSH and were increased maximally by treatment with both hormones. In serum-free cultures of rat granulosa cells, cyclin D2 mRNA was rapidly elevated in response to FSH, forskolin,..
  28. pmc Comprehensive analysis of hormone and genetic variation in 36 genes related to steroid hormone metabolism in pre- and postmenopausal women from the breast and prostate cancer cohort consortium (BPC3)
    L Beckmann
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 96:E360-7. 2011
    ..Sex steroids play a central role in breast cancer development...
  29. ncbi Steroid hormones regulate gene expression posttranscriptionally by altering the stabilities of messenger RNAs
    Nancy H Ing
    Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 72:1290-6. 2005
    b>Hormones exert powerful effects on reproductive physiology by regulating gene expression...
  30. ncbi Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis
    P J Havel
    Department of Nutrition, University of California, Davis, California 95616, USA
    Exp Biol Med (Maywood) 226:963-77. 2001
    ..Other nutrients (e.g., amino acids and fatty acids) and GI peptide hormones, most notably cholecystokinin, are also involved in short-term regulation of food intake...
  31. ncbi Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids
    J F Louet
    , UPR 1524 CNRS, 9 rue Jules Hetzel, 92190 Meudon, France
    Biochem Soc Trans 29:310-6. 2001
    ..on the transcriptional regulation of liver carnitine palmitoyltransferase I (L-CPT I) by pancreatic and thyroid hormones and by long-chain fatty acids (LCFA)...
  32. ncbi Hormones are key actors in gene x environment interactions programming the vulnerability to Parkinson's disease: glia as a common final pathway
    Bianca Marchetti
    OASI Institute for Research and Care on Mental Retardation and Brain Aging IRCCS, Neuropharmacology Section, Via Conte Ruggero 73, 94018 Troina EN, Italy
    Ann N Y Acad Sci 1057:296-318. 2005
    ..In particular, genetic factors, including gender, may interact with early life events such as exposure to hormones, endotoxins, or neurotoxins, thereby influencing disease predisposition and/or severity, but little is known ..
  33. ncbi Hormones as indicators of stress
    E Möstl
    Institut fur Biochemie, Veterinarmedizinische Universitat, Veterinarplatz 1, Austria
    Domest Anim Endocrinol 23:67-74. 2002
    ..During stress, various endocrine responses are involved to improve the fitness of the individual. The front-line hormones to overcome stressful situations are the glucocorticoids and catecholamines...
  34. ncbi Breast cancer: hormones and other risk factors
    B S Hulka
    Department of Epidemiology, School of Public Health, University of North Carolina, 2104 McGavran Greenberg Building, CB 7400, Chapel Hill, NC 27599 7400, USA
    Maturitas 38:103-13; discussion 113-6. 2001
    ..Whereas alcohol consumption is associated with increased risk, most environmental factors, including polychlorinated compounds and electromagnetic fields, are not...
  35. ncbi Expression of gonadotropin receptor and growth responses to key reproductive hormones in normal and malignant human ovarian surface epithelial cells
    V Syed
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 61:6768-76. 2001
    Epidemiological data have implicated reproductive hormones as probable risk factors for ovarian cancer (OCa) development...
  36. ncbi Regulation of beta-cell mass by hormones and growth factors
    J H Nielsen
    Department of Cell Biology, Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 50:S25-9. 2001
    ....
  37. ncbi Fetal uninephrectomy leads to postnatal hypertension and compromised renal function
    Karen M Moritz
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia k moritz hfi unimelb edu au
    Hypertension 39:1071-6. 2002
    ..These results suggest that formation of a low nephron number in utero, may result in elevated blood pressure and compromised renal function in later life...
  38. ncbi Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, 8000 Arhus C, Denmark
    Annu Rev Nutr 21:407-28. 2001
    ..than nonspecific pinocytosis, accounts for the apical epithelial uptake of many carrier-bound nutrients and hormones. The two interacting receptors of distinct evolutionary origin, megalin and cubilin, are main receptors in this ..
  39. ncbi The neuroanatomical axis for control of energy balance
    Harvey J Grill
    Graduate Group of Psychology, University of Pennsylvania, Philadelphia, 19104, USA
    Front Neuroendocrinol 23:2-40. 2002
    ....
  40. doi Advantages and challenges of mass spectrometry assays for steroid hormones
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Steroid Biochem Mol Biol 121:491-5. 2010
    Although steroid hormones have been measured, primarily in urine, by gas chromatography-mass spectrometry (GC-MS) assays for many years, in the past decade both clinical and research laboratories have dramatically increased usage of ..
  41. ncbi Hormones and the stressed brain
    E Ronald de Kloet
    Division of Medical Pharmacology, LACDR LUMC, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Ann N Y Acad Sci 1018:1-15. 2004
    ..In the latter transcriptional regulation, the corticosteroid hormones have two modes of operation...
  42. doi Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderate-weight women
    Rebecca L Robker
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, 5005 Australia
    J Clin Endocrinol Metab 94:1533-40. 2009
    ..Obese women experience longer times to conception, even if they are young and cycling regularly, which is suggestive of alterations in ovarian function during the periconceptual period...
  43. pmc Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hormones
    Malena B Rone
    The Research Institute of the McGill University Health Centre and Departments of Medicine, Biochemistry and Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1A4, Canada
    Mol Endocrinol 26:1868-82. 2012
    Steroid hormones are critical for organismal development and health...
  44. pmc Wnt and mammary stem cells: hormones cannot fly wingless
    Kevin Roarty
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Curr Opin Pharmacol 10:643-9. 2010
    ..These processes are intricately guided by the influence of systemic hormones and local factors...
  45. doi Westernized-like-diet-fed rats: effect on glucose homeostasis, lipid profile, and adipocyte hormones and their modulation by rosiglitazone and glimepiride
    Mona Schaalan
    Biochemistry Department, Faculty of Pharmacy, Misr International University MIU, Cairo, Egypt
    J Diabetes Complications 23:199-208. 2009
    ..These results show that this diet could be used to induce an effect that mimics human type 2 diabetes with its metabolic disturbances and is suitable for screening the antidiabetic agents used for management of this disease...
  46. doi Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis
    A Kalsbeek
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Mol Cell Endocrinol 349:20-9. 2012
    The pronounced daily variation in the release of adrenal hormones has been at the heart of the deciphering and understanding of the circadian timing system...
  47. ncbi SwePep, a database designed for endogenous peptides and mass spectrometry
    Maria Fälth
    Laboratory for Biological and Medical Mass Spectrometry, Biomedical Centre, Box 583, Uppsala University, SE 75123 Uppsala, Sweden
    Mol Cell Proteomics 5:998-1005. 2006
    ..This new approach holds great potential for removing the bottleneck that occurs during the identification process in the field of peptidomics. The SwePep database is available to the public...
  48. ncbi Hormone signaling in evolution and development: a non-model system approach
    Andreas Heyland
    Department of Zoology, University of Florida, Gainesville, Florida, USA
    Bioessays 27:64-75. 2005
    ..Because of this property, we argue that hormones are frequently involved in the coordination of life history transitions (LHTs) and their evolution (LHE)...
  49. pmc Transcriptomic analysis of neuropeptides and peptide hormones in the barnacle Balanus amphitrite: evidence of roles in larval settlement
    Xing Cheng Yan
    Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
    PLoS ONE 7:e46513. 2012
    ..and neuroactive substances of the barnacle, a comprehensive understanding of neuropeptides and peptide hormones remains lacking...
  50. doi The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development
    Krystyna Nahlik
    Institut für Mikrobiologie and Genetik, Georg August Universitat, D 37077 Gottingen, Germany
    Mol Microbiol 78:964-79. 2010
    ..CSN promotes the formation of asexual spores by regulating developmental hormones produced by PpoA and PpoC dioxygenases...
  51. ncbi Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis
    Rainer H Straub
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 46:654-62. 2002
    To compare levels of steroid hormones in relation to cytokines and to study levels of cortisol or dehydroepiandrosterone (DHEA) in relation to other adrenal hormones in untreated patients with early rheumatoid arthritis (RA) and reactive ..
  52. doi Do hormones influence melanoma? Facts and controversies
    Amie Gupta
    Department of Dermatology, University of Maryland School of Medicine, 419 W Redwood St, Baltimore, MD 21201, USA
    Clin Dermatol 28:287-92. 2010
    The issue of whether hormones influence malignant melanoma (MM) has been controversial for many years...
  53. doi Stress hormones and immunological responses to a dual challenge in professional firefighters
    Chun Jung Huang
    Florida Atlantic University, Boca Raton, FL, USA
    Int J Psychophysiol 75:312-8. 2010
    ..In addition, this evidence provides insight into the possible mechanisms that explain the link between physical activity, psychological stress, and stress-related diseases...
  54. pmc Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant
    Victoria Persky
    University of Illinois, School of Public Health, 1603 West Taylor St, Chicago, IL 60612, USA
    Environ Health 11:57. 2012
    Studies have shown associations of diabetes and endogenous hormones with exposure to a wide variety of organochlorines...
  55. ncbi Cytokines and hormones in the regulation of hypoxia inducible factor-1alpha (HIF-1alpha)
    Jie Zhou
    Institute of Biochemistry I, University of Frankfurt Medical School, Frankfurt, Germany
    Cardiovasc Hematol Agents Med Chem 4:189-97. 2006
    ..Here we summarize current knowledge and existing concepts that help to understand how cytokines and hormones affect protein accumulation of HIF-1alpha and discuss potential implications of activating HIF-1 under normoxia...
  56. ncbi Effects of strength training on muscle power and serum hormones in middle-aged and older men
    M Izquierdo
    Centro de Investigación y Medicina del Deporte de Navarra, Gobierno de Navarra, 31002 Pamplona, Navarra, Spain
    J Appl Physiol (1985) 90:1497-507. 2001
    ....
  57. ncbi Hormones, nevi, and melanoma: an approach to the patient
    Marcia S Driscoll
    Department of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Am Acad Dermatol 57:919-31; quiz 932-6. 2007
    For many years, clinicians have been concerned about a potential adverse effect of pregnancy-associated hormones and exogenous hormones on melanocytic nevi and malignant melanoma...
  58. ncbi Cardiovascular death and the metabolic syndrome: role of adiposity-signaling hormones and inflammatory markers
    Claudia Langenberg
    Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0607, USA
    Diabetes Care 29:1363-9. 2006
    Levels of adiposity-signaling hormones and inflammatory markers are less favorable in individuals with the metabolic syndrome; their role in the association between the metabolic syndrome and cardiovascular mortality remains unclear.
  59. doi Regulation of the rose Rh-PIP2;1 promoter by hormones and abiotic stresses in Arabidopsis
    Yunhui Li
    Department of Ornamental Horticulture, China Agricultural University, 100094, Beijing, China
    Plant Cell Rep 28:185-96. 2009
    ..Taken together, our results indicated that the Rh-PIP2;1 promoter responded to hormones and abiotic stresses in a developmental- and spatial-dependent manner, and the -886 to -828 region was crucial ..
  60. doi Molecular mechanisms of fat preference and overeating
    Dany Gaillard
    Physiologie de la Nutrition, UMR INSERM U866, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation ENSBANA, Universite de Bourgogne, Dijon, France
    Ann N Y Acad Sci 1141:163-75. 2008
    ..This paper provides a brief overview of postoral regulation of food intake by lipids and then highlights recent data suggesting the existence of a "fatty taste" which might contribute to lipid overeating and hence to the risk of obesity...
  61. pmc Neuroendocrine disturbances in Huntington's disease
    Nadine Saleh
    Centre de référence maladie de Huntington, AP HP, Groupe Henri Mondor Albert Chenevier Pitié Salpétrière, Creteil, Paris, France
    PLoS ONE 4:e4962. 2009
    ..and to determine the relationship with weight loss seen in HD METHODS AND FINDING: We compared plasma levels of hormones from the five pituitary axes in 219 patients with genetically documented HD and in 71 sex- and age-matched ..
  62. ncbi Gender and ethnic differences in urinary stress hormones: the population-based Chicago Health, Aging, and Social Relations Study
    Christopher M Masi
    Institute for Mind and Biology, University of Chicago, Chicago, Illinois 60637, USA
    J Appl Physiol (1985) 97:941-7. 2004
    ..The purpose of this study was to determine whether urinary stress hormones were higher among men and blacks in a population-based sample...
  63. pmc Brain meets body: the blood-brain barrier as an endocrine interface
    William A Banks
    Veterans Affairs Puget Sound Health Care System and Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Endocrinology 153:4111-9. 2012
    ..However, this does not prevent hormones from entering the brain, but shifts the main control of entry to the BBB...
  64. pmc Associations of exercise-induced hormone profiles and gains in strength and hypertrophy in a large cohort after weight training
    Daniel W D West
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, 1280 Main St West, Hamilton, ON, L8S 4K1, Canada
    Eur J Appl Physiol 112:2693-702. 2012
    ..We report that the acute exercise-induced systemic hormonal responses of cortisol and GH are weakly correlated with resistance training-induced changes in fibre CSA and LBM (cortisol only), but not with changes in strength...
  65. ncbi Four peptide hormones decrease the number of human breast adenocarcinoma cells
    B A Vesely
    Department of Biochemistry and Molecular Biology, University of South Florida Cardiac Hormone Center and James A Haley Veteran s Administration Medical Center, Tampa, FL, USA
    Eur J Clin Invest 35:60-9. 2005
    A family of six hormones, i.e...
  66. pmc Utilization of antihypertensives, antidepressants, antipsychotics, and hormones in Alzheimer disease
    Carolyn W Zhu
    Geriatric Research, Education, and Clinical Center GRECC and Health Services Research and Development HSR and D Center for Study of Health Care across Systems and Sites of Care, James J Peters VA Medical Center, Bronx, New York, NY 10468, USA
    Alzheimer Dis Assoc Disord 25:144-8. 2011
    ..patient characteristics and use of 4 drug classes (antihypertensives, antidepressants, antipsychotics, and hormones) that showed significant changes in use rates over time in patients with Alzheimer disease...
  67. doi Screening of pharmaceuticals and hormones at the regional scale, in surface and groundwaters intended to human consumption
    Emmanuelle Vulliet
    Institut des Sciences Analytiques UMR5280, Département Service Central d Analyse, Echangeur de Solaize, Chemin du Canal, F 69360 Solaize, France
    Environ Pollut 159:2929-34. 2011
    ..for the health of populations, to certain classes of emerging substances, several families of pharmaceuticals and hormones were looked for in waters intended to drinking...
  68. doi Fate of steroid hormones and endocrine activities in swine manure disposal and treatment facilities
    Sarah Combalbert
    INRA, UR050 Laboratoire de Biotechnologie de l Environnement, Avenue des Etangs, F 11100 Narbonne, France
    Water Res 46:895-906. 2012
    Manure may contain high concern endocrine-disrupting compounds (EDCs) such as steroid hormones, naturally produced by pigs, which are present at μgL(-1) levels...
  69. pmc Convergence of hormones, inflammation, and energy-related factors: a novel pathway of cancer etiology
    Martha L Slattery
    Department of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    Cancer Prev Res (Phila) 2:922-30. 2009
    ..CRC) is a multifactorial disease with several hypothesized etiologic factors including inflammatory processes; hormones such as estrogen, androgen, and insulin; and energy-related factors...
  70. ncbi Molecular architecture and biorecognition processes of the cystine knot protein superfamily: part I. The glycoprotein hormones
    M T Hearn
    Centre for Bioprocess Technology, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    J Mol Recognit 13:223-78. 2000
    ..In the present review article, specific emphasis has been placed on advances with the glycoprotein hormones (GPHs) that have facilitated greater insight into their physiological functions, molecular structures and most ..
  71. ncbi Skin permeation of different steroid hormones from polymeric coated liposomal formulations
    Babette Biruss
    Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria
    Eur J Pharm Biopharm 62:210-9. 2006
    ..The liposomes contained 1% (w/w) of the steroid hormones. Standard diffusion experiments were performed...
  72. pmc Evening chronotype is associated with changes in eating behavior, more sleep apnea, and increased stress hormones in short sleeping obese individuals
    Eliane A Lucassen
    Clinical Center, National Institutes of Health, Bethesda, MD, USA
    PLoS ONE 8:e56519. 2013
    ..5 hours per night...
  73. ncbi Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women
    Anne B Loucks
    Department of Biological Sciences, Ohio University, Athens, Ohio 45701, USA
    J Clin Endocrinol Metab 88:297-311. 2003
    ..beta-hydroxybutyrate, GH, and cortisol and contrasted with the dependencies displayed by the other metabolic hormones (simultaneously P < 0.05)...
  74. ncbi The role of hormones, cytokines and heat shock proteins during age-related muscle loss
    Claire E Lee
    School of Clinical Sciences, Faculty of Medicine, University of Liverpool, Liverpool L69 3GA, UK
    Clin Nutr 26:524-34. 2007
    ..the process of skeletal muscle degeneration with ageing, normal and aberrant skeletal muscle regeneration, and to address recent research on the effects of gender and sex steroid hormones during the process of age-related muscle loss.
  75. pmc Endogenous hormones and coronary heart disease in postmenopausal women
    Yu Chen
    Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016 3240, United States
    Atherosclerosis 216:414-9. 2011
    ..These findings suggest that circulating estradiol and SHBG are not associated with CHD risk in postmenopausal women beyond what can be explained by the variation in hypertension status, BMI, and cholesterol...
  76. ncbi Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part I: HPA axis responses
    Arieh Y Shalev
    Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 11:365-72. 2008
    ..Survivors with (n=31) and without (n=124) PTSD at 5 months had similar levels of hormones at all times. Plasma cortisol levels decreased with time in both groups...
  77. ncbi Role of hormones in pilosebaceous unit development
    D Deplewski
    Department of Medicine and Pediatrics, The University of Chicago Pritzker School of Medicine, Illinois 60637 1470, USA
    Endocr Rev 21:363-92. 2000
    ..Many other hormones such as GH, insulin-like growth factors, insulin, glucocorticoids, estrogen, and thyroid hormone play important ..
  78. ncbi Regulation of pituitary somatotroph differentiation by hormones of peripheral endocrine glands
    Tom E Porter
    Department of Animal and Avian Sciences, Molecular and Cell Biology Program, University of Maryland, College Park, MD 20742, USA
    Domest Anim Endocrinol 29:52-62. 2005
    ..growth hormone (GH) producing cells in the chick and the rat is regulated by adrenal glucocorticoids and thyroid hormones. Somatotroph differentiation can be induced in cultures of chick embryonic and rat fetal pituitary cells with ..
  79. pmc Mono-ADP-ribosylation of the G protein betagamma dimer is modulated by hormones and inhibited by Arf6
    Nadia Dani
    G Protein mediated Signalling Laboratory, Consorzio Mario Negri Sud, Via Nazionale, 8 A 66030 Santa Maria Imbaro Chieti, Italy
    J Biol Chem 286:5995-6005. 2011
    ..These data provide further understanding of the mechanisms that regulate endogenous ADP-ribosylation of the Gβ subunit, and they demonstrate a novel role for Arf6 in hormone regulation of Gβ subunit mono-ADP-ribosylation...
  80. doi Determination of steroid hormones in biological and environmental samples using green microextraction techniques: an overview
    Jana Aufartová
    Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic
    Anal Chim Acta 704:33-46. 2011
    Residues of steroid hormones have become a cause for concern because they can affect the biological activity of non-target organisms...
  81. doi Pharmaceuticals, hormones and bisphenol A in untreated source and finished drinking water in Ontario, Canada--occurrence and treatment efficiency
    Sonya Kleywegt
    Standards Development Branch, Ontario Ministry of the Environment, 40 St Clair Avenue West, Toronto, Ontario, Canada
    Sci Total Environ 409:1481-8. 2011
    ..MOE) conducted a survey in 2006 on emerging organic contaminants (EOCs) which included pharmaceuticals, hormones and bisphenol A (BPA)...
  82. pmc Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China
    Sue K Park
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, EPS 5024, MSC 7234, Bethesda, MD 20892 7234, USA
    Carcinogenesis 30:606-14. 2009
    ..To further clarify the role of hormones in biliary tract cancers and biliary stones, we genotyped 18 single-nucleotide polymorphisms (SNPs) in nine genes ..
  83. doi Semen quality, reproductive hormones and fertility of men operated for hypospadias
    C Asklund
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:80-7. 2010
    ..Therefore, we investigated semen quality and reproductive hormones of 92 men with isolated hypospadias (IH) and 20 with hypospadias and additional genital disorders (HAGD) and ..
  84. ncbi Major advances associated with reproduction in dairy cattle
    K Moore
    Department of Animal Sciences, University of Florida, Gainesville, 32611 0910, USA
    J Dairy Sci 89:1254-66. 2006
    ....
  85. pmc Inhibitory activity of YKL-40 in mammary epithelial cell differentiation and polarization induced by lactogenic hormones: a role in mammary tissue involution
    Steve Scully
    Pioneer Valley Life Sciences Institute, University of Massachusetts, Springfield, Massachusetts, United States of America
    PLoS ONE 6:e25819. 2011
    ..in vivo, we grew a mammary epithelial cell line 76N MECs in a 3-D Matrigel system in the presence of lactogenic hormones including prolactin, hydrocortisone, and insulin...
  86. ncbi Effect of osmotic shrinkage and hormones on the expression of Na+/H+ exchanger-1, Na+/K+/2Cl- cotransporter and Na+/K+ -ATPase in gill pavement cells of freshwater adapted Japanese eel, Anguilla japonica
    William K F Tse
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong
    J Exp Biol 210:2113-20. 2007
    ..In this paper, we aimed to determine the effects of osmotic hypertonicity, hormones and cellular signaling molecules on the expression of ion transporters in the cultured primary freshwater ..
  87. doi Modification of endothelial biology by acute and chronic stress hormones
    T Nickel
    Medizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig Maximilians Universitat, Munchen, Germany
    Microvasc Res 78:364-9. 2009
    ..The present study was designed to evaluate the relationship between acute (epi- and norepinephrine) and chronic stress hormones (dexamethasone, beta-endorphin, corticotropin releasing hormone) and endothelial dysfunction.
  88. doi Steroid hormones specifically modify the activity of organic anion transporting polypeptides
    Anna Koenen
    Department of Pharmacology, Ernst Moritz Arndt University, Felix Haussdorf Str 3, 17487 Greifswald, Germany
    Eur J Pharm Sci 47:774-80. 2012
    ..of progesterone on OATP2B1-mediated atorvastatin and glibenclamide uptake and studied the impact of steroid hormones on the transport activity of OATP1A2, OATP1B1 and OATP1B3...
  89. doi Hormones and cardiovascular disease: a shift in paradigm with clinical consequences?
    Bregje van Zaane
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Semin Thromb Hemost 35:478-87. 2009
    ..In this article, we discuss in detail the contribution of thyroid hormones, cortisol, the somatotropic hormones, and prolactin in the development of CVD...
  90. doi Differential effects of restricted versus unlimited high-fat feeding in rats on fat mass, plasma hormones and brain appetite regulators
    T Shiraev
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    J Neuroendocrinol 21:602-9. 2009
    ....
  91. ncbi Pancreatic polypeptide reduces appetite and food intake in humans
    R L Batterham
    Department of Metabolic Medicine, Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Endocrinol Metab 88:3989-92. 2003
    ..Overall PP infusion reduced cumulative 24-hour energy intake by 25.3 +/- 5.8%. In conclusion our data demonstrates that PP causes a sustained decrease in both appetite and food intake...
  92. pmc Minireview: Glucagon in stress and energy homeostasis
    B J Jones
    Department of Investigative Medicine, Commonwealth Building, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0HS, United Kingdom
    Endocrinology 153:1049-54. 2012
    ..These findings seem more in keeping with glucagon having some role as a hormone enhancing the response to stress...
  93. doi The specificity of binding of glycoprotein hormones to their receptors
    G Caltabiano
    Laboratori de Medicina Computacional, Unitat de Bioestadistica, Facultat de Medicina, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Cell Mol Life Sci 65:2484-92. 2008
    ..at the molecular level, these important discriminating determinants for selective binding of glycoprotein hormones to their receptors, as well as natural mutations, observed in patients with gestational hyperthyroidism or ..
  94. ncbi Stress hormones in Ménière's disease and acoustic neuroma
    Kathleen C Horner
    Laboratoire de Physiologie Neurovégétative, Cnrs UMR 6153, 1147 INRA, Universite Paul Cezanne, faculté des sciences St Jérôme, Cases 351 352, Avenue Escadrille Normandie Niemen, 13397 Marseille Cedex 20, France
    Brain Res Bull 66:1-8. 2005
    ..We investigated stress hormones in Ménière's patients and patients with acoustic neuroma...
  95. pmc Rapid seasonal-like regression of the adult avian song control system
    Christopher K Thompson
    Graduate Program in Neurobiology and Behavior, University of Washington, Box 351525, Seattle, WA 98195 1525, USA
    Proc Natl Acad Sci U S A 104:15520-5. 2007
    ..These results reveal that the rapid regression of the song control system provides a model for the important role sex steroid hormones play in mediating adult neural plasticity and in neuroprotection.
  96. doi Role of hormones in acne vulgaris
    Megha Kataria Arora
    Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India
    Clin Biochem 44:1035-40. 2011
    To elucidate the role of endogenous hormones like testosterone, progesterone, estrogen, insulin-like growth factor, insulin and glucocorticoids in a common skin condition acne vulgaris.
  97. doi Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women
    Nobuyasu Yoshimoto
    Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Cancer Sci 102:2065-72. 2011
    ..of breast cancer, age at menopause, use of hormone replacement therapy, alcohol intake, and smoking), serum hormones and growth factors (estradiol, testosterone, prolactin, insulin-like growth factor 1 [IGF1] and IGF binding ..
  98. ncbi Motherhood and the hormones of pregnancy modify concentrations of hippocampal neuronal dendritic spines
    Craig H Kinsley
    Department of Psychology Center for Neuroscience, 103 Richmond Hall, University of Richmond, VA 23173, USA
    Horm Behav 49:131-42. 2006
    Short-term fluctuations in steroid hormones such as estradiol (E2) and progesterone (P) can affect the concentration of hippocampal dendritic spines in adult, cycling nulliparous female rats...
  99. ncbi Epidemiology of urinary melatonin in women and its relation to other hormones and night work
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:936-43. 2004
    ..There is little information, however, about the interrelationships of night work, urinary melatonin levels, and levels of plasma steroid hormones in women.
  100. ncbi Peripheral arousal-related hormones modulate norepinephrine release in the hippocampus via influences on brainstem nuclei
    Teiko Miyashita
    Department of Psychology, The University of Virginia, P O Box 400400, 102 Gilmer Hall, Charlottesville, VA 22904 4400, USA
    Behav Brain Res 153:87-95. 2004
    ..These findings indicate that the mnemonic effects of EPI reported in a wide range of learning conditions may not be mediated solely by NE release in the amygdala, but may also involve coactivation of the HIPP NE system...
  101. pmc Effects of exercise on energy-regulating hormones and appetite in men and women
    Todd A Hagobian
    University of Massachusetts Amherst, Energy Metabolism Laboratory, Department of Kinesiology, 107 Totman Bldg, 30 Eastman Lane, Amherst, MA 01003, USA
    Am J Physiol Regul Integr Comp Physiol 296:R233-42. 2009
    ..study was to evaluate whether this observation could be related to sex differences in the way energy-regulating hormones and appetite perception respond to exercise...

Research Grants75

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..This is known as chronic CSC. - Chronic CSC may be caused by hormones called androgens. Finasteride is a drug that can alter the effects certain of androgens...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..This is known as chronic CSC. - Chronic CSC may be caused by hormones called androgens. Finasteride is a drug that can alter the effects certain of androgens...
  3. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  4. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..to metabolism and excretion of exogenous compounds such as drugs or toxins as well as endogenous compounds like hormones, bilirubin and bile acids and cholesterol...
  5. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    ..Research training to be afforded by the present application to professional veterinary students will contribute to efforts geared to preparing future veterinarians to meet these challenges. ..
  6. SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016
    ..The long-term goal is to identify the regulatory mechanisms to assist in the development of novel therapeutic protocols for better treatments. ..
  7. Sogol Mostoufi-Moab; Fiscal Year: 2016
    ..survivors stems from the inverse relation between bone and fat formation within the bone marrow cavity, where hormones and transcription factors regulate mesenchyme stem cell (MSC) differentiation into osteoblasts or osteocytes...
  8. Yun Fai Chris Lau; Fiscal Year: 2014
    ..This project will shed important insights on how the Y-oncogene and X-tumor suppressor operate and how one can interfere or boost their actions respectively to treat prostate cancer. ..
  9. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..In many cases, nephrotic syndrome can be treated effectively with the use of artificial steroid hormones such as prednisone...
  10. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..abstract_text> ..
  11. PHILIP LEE JOHNSON; Fiscal Year: 2016
    ..provided by applicant): Currently I have had extensive training in: 1) neuroendocrinology of female sex hormones and behavior during my Masters with Thesis;2) neuroendocrinology and functional neuroanatomy of stress responses ..
  12. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..Carnell's interests. Her proposed Mentor for the K99 is Dr. Allan Geliebter, an expert in the role of gut hormones in eating disorders and obesity, and well-published author in neuroimaging of obesity. Her Co-mentor is Dr...
  13. Paolo Fanti; Fiscal Year: 2014
    ..the plasma and urine glycoproteome, with focus on those glycoproteins serving as inflammatory cell messengers and hormones. These variables will be monitored in relation to both treatment allocation and prevalent blood and urine levels ..
  14. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..2. Evaluate the potential therapeutic effects of CST and its variants on insulin sensitivity and baroreflex sensitivity and heart rate variability in high fat diet-induced insulin resistant and in db/db diabetic mice. ..
  15. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..The mechanisms leading to the sensation of appetite and the release of gastrointestinal hormones in response to meal stimuli play an important role in the regulation of body weight homeostasis...
  16. VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2014
    ..Fam20C phosphorylates casein and several hormones specifically at S-x-E/pS motifs in the lumen of the Golgi...
  17. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..The proposed research is hypothesis-driven, is based on strong preliminary evidence, is innovative with high likelihood for novel findings with applicability to humans. ..
  18. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..We seek support for additional blood markers to PROMIS by assaying plasma biomarkers potentially relevant to atherogenesis, plaque rupture and/or thrombosis. ..
  19. KRISTEN RACHEL VELLA; Fiscal Year: 2014
    ..abstract_text> ..
  20. NICOLE RENEE TARTAGLIA; Fiscal Year: 2015
    ..males) and represents an excellent model in which to study the interplay between genetic factors and reproductive hormones on neurodevelopment...
  21. Ashraf Gorgey; Fiscal Year: 2016
    ..The rationale is based on the evidence that individuals with SCI experience decline in anabolic hormones which may be responsible for the deterioration in body composition and metabolic profiles and leads to increase ..
  22. Charles W Wilkinson; Fiscal Year: 2016
    ..Hypopituitarism, as defined by deficient production of one or more pituitary hormones measured at least one year after injury, has been reported to occur in 30-70% of TBI cases, and its occurrence is ..
  23. Ming Zhou; Fiscal Year: 2014
    ..Compounds that selectively block urea transporter will have diuretic effect but will not interfere with the salt balance. ..
  24. Susan Carnell; Fiscal Year: 2015
    ..Carnell's interests. Her proposed Mentor for the K99 is Dr. Allan Geliebter, an expert in the role of gut hormones in eating disorders and obesity, and well-published author in neuroimaging of obesity. Her Co-mentor is Dr...
  25. Bayar Thimmapaya; Fiscal Year: 2016
    ....
  26. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..Cachexia is also a complication of many other conditions including lung and heart disease and aging, the knowledge generated through this proposal also will help us in establishing new therapies for these conditions. ..
  27. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..The synthesis and discovery of an optimal locally active androgen antagonist to be applied to the skin to treat acne, alopecia, seborrhea (and hirsutism in women) are the subjects of this application. ..
  28. Mark W Chapleau; Fiscal Year: 2015
    ..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
  29. Alan Frazer; Fiscal Year: 2016
    ..It is likely that effects of gonadal hormones contribute to the development of MDD (as well as postpartum depression) and this may be part of the reason why ..
  30. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..The findings would shed light on the role of immune system in health and disease and may identify new therapeutic approaches for arthritis. ..
  31. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..arginylation as a posttranslational modification, transcriptional regulation of differentiation, growth hormones, respiration, cell cycle, cell death, spermatogenesis, obesity, stress, immunology, eye development, and dinosaur ..
  32. Paul E Micevych; Fiscal Year: 2016
    ..This type of infertility exhibits excess estrogen production without ovulation that can lead to polycystic ovary syndrome, irregular vaginal bleeding, metabolic abnormalities as well as endometrial polyps, hyperplasia, and even cancer. ..
  33. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..The overall goal of this project is use these newly identified gene products as novel therapeutic targets for detection and treatment of NSCLC. ..
  34. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Vitamin D and estrogen are two steroid hormones long recognized for their ability to influence the growing skeleton...
  35. Maria Diakonova; Fiscal Year: 2014
    ..Understanding how these proteins work together will help to design new therapeutic approaches and possibly drugs for treatment of different human diseases and breast cancer. ..
  36. Epigenetics of Sex Differences in Brain and Behavior
    BRIDGET NUGENT; Fiscal Year: 2012
    ....
  37. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
    ....
  38. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..Studies in animals and humans suggest that sleep deprivation leads to changes in hormones and increased sympathetic nervous system (SNS) function amongst other effects...
  39. Diane Lebesgue; Fiscal Year: 2014
    ..This will equip me to develop independent research projects on the role of sex steroid hormones in the brain that do not overlap with the research projects going on in the lab of either of my mentors...
  40. DAVID MATTHEW KELLER; Fiscal Year: 2016
    ..In pancreatic [unreadable]-cells, intracellular cAMP is elevated following exposure to hormones, neurotransmitters, and other nutrient secretagogues, and potentiates glucose-stimulated insulin secretion...
  41. Haifei Shi; Fiscal Year: 2015
    ..We will first investigate the hypothesis that gonadal hormones modulate the activity of the BDNF/TrkB signaling...
  42. UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2015
    ..Pajvani will need in order to become an independent translational medical researcher and a productive member of the academic medical community. ..
  43. John S Davis; Fiscal Year: 2014
    ..Considering the importance sex steroids in health and disease, we must have a better understanding of the mechanisms controlling the synthesis of steroid hormones.
  44. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ....
  45. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..The analysis of the role of Akt2 in diabetic cardiomyopathy may lead to new therapies that may help to reduce the high mortality rate associated with diabetes. ..
  46. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..between telomere length and other analytes already measured in the trial: DNA damage repair (COMET), sex hormones, insulin &glucose, inflammation (C-reactive protein, serum amyloid A, interleukin-6), insulin like growth ..
  47. THOMAS STERLING SCANLAN; Fiscal Year: 2014
    ....
  48. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ....
  49. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..digested nutrients with the mucosa of the distal small intestine resulting in increased secretion of gut hormones such as glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY)...
  50. Fredric B Kraemer; Fiscal Year: 2016
    ....
  51. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..Both hormones play a role in the pathogenesis of hypertension, cardiovascular fibrosis, and nephrosclerosis...
  52. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
    ....
  53. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..aging and is defined by permanent changes in ovarian function, we still do not understand how postmenopausal sex hormones affect diabetes risk...
  54. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..Our goal is to discover estrogens that do not promote cancer, but retain the beneficial of estrogens on body weight and fat accumulation. ..
  55. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2012
    ..In addition, we aim to understand how this hormone engages sensory-regulated, plasticity-associated gene expression, and ultimately modulates higher-order behaviors such as auditory discrimination. ..
  56. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2012
    ..It is generally believed that the female advantage is associated with the effects of sex hormones. This project will test the question of whether the presence of cellular mosaicism of X chromosome-linked protein ..
  57. Rebecca A Simmons; Fiscal Year: 2016
    ..Endocrine disrupting compounds are exogenous substances that mimic endogenous hormones in the endocrine pathway...
  58. Iris Z Jaffe; Fiscal Year: 2016
    ..abstract_text> ..
  59. Anna Eisenstein; Fiscal Year: 2015
    ..Ravid, a Biochemist and expert in vascular and adenosine biology, and Dr. Gokce, a Clinician Scientist with access to human samples and expertise in studying human adipose tissue. ..
  60. Metabolic Adapation and Control of Lactation in Humans
    Morey W Haymond; Fiscal Year: 2010
    ....
  61. Edward P Feener; Fiscal Year: 2016
    ..These studies could reveal new therapeutic strategies to treat diabetic macular edema, a leading cause of vision loss. ..
  62. C Michael Hart; Fiscal Year: 2016
    ..The results of this proposal can thereby define novel and effective therapeutic strategies to regulate programs of gene expression involved in PH pathogenesis. ..
  63. PAUL CHRISTIAN SCHILLER; Fiscal Year: 2015
    ..Aim 3: Determine the role of progerin in the bone forming capacity of hMSCs in vivo. We expect that increased progerin expression in hMSCs will decrease their bone forming capacity in vivo. ..
  64. Site-directed Chemotherapy for Breast Cancer using Novel Angiogenesis Inhibitor
    Shaker A Mousa; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Recent evidence has been provided that thyroid hormones may also play a role in carcinogenesis, and pioneering investigations in this area have demonstrated that the thyroid hormones such as 3,5,3&..
  65. Long-acting Growth Hormone for Treating HIV-Associated Adipose Redistribution Syn
    George Cox; Fiscal Year: 2009
    ....
  66. Effect of Polybrominated Diphenal Ether Flame Retardant Exposure on Osteogenesis
    Deena J Small; Fiscal Year: 2010
    ..These compounds are endocrine disrupting chemicals with a structure very similar to thyroid hormones, although the molecular mechanism(s) by which PBDE modifies thyroid hormone function is (are) not clear...
  67. The relative roled of sex and genes during development of systemic autoimmunity
    TRINE NORGAARD JORGENSEN; Fiscal Year: 2010
    ..understanding of the etiology of SLE implies important roles for genetics and environmental factors such as sex hormones. Analyses of mouse models of SLE have proven good models for both;however, the relative importance of genes ..
  68. EXPRESSION OF OVARIAN INHIBIN AND ACTIVIN GENES
    Kelly Mayo; Fiscal Year: 1993
    The goal of this project is to examine the expression and regulation of genes encoding gonadal polypeptide hormones that are involved in controlling mammalian reproduction...
  69. Identification of Novel Alpha Amidated Peptide Hormones
    ANGELO CONSALVO; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Peptide hormones with a C-terminal a-amide functionality are widely important, being found in mammals, insects, cnidarians and plants...
  70. Sex Hormones and Rat Anterior Cruciate Ligament Strength
    William A Romani; Fiscal Year: 2010
    ..Gender specific differences in the hormonal milieu and response to specific steroid sex hormones have been suggested as potential causes for the disparities in ACL strength and injury risk between males and ..
  71. GALANIN REGULATION OF PITUITARY REPRODUCTIVE HORMONES
    ANGELA BAUER DANTOIN; Fiscal Year: 1999
    ..abstract_text> ..