Genomes and Genes
Summary: Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.
Publications266 found, 100 shown here
- Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidismTroels Herlin
Department of Pediatrics, Skejby Sygehus, Aarhus University Hospital, Denmark
Scand J Rheumatol 31:46-9. 2002..Triplet A and B, but not C, both developed a strongly positive elastase-ANCA. Our results confirm the importance of a genetic factor influencing the susceptibility to drug-induced LE...
- Antithyroid drugsDavid S Cooper
Division of Endocrinology, Sinai Hospital of Baltimore, The Johns Hopkins University School of Medicine, Baltimore 21215, USA
N Engl J Med 352:905-17. 2005
- Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitidesBranka Bonaci-Nikolic
Institute of Allergy and Clinical Immunology, Clinical Centre of Serbia, Belgrade, Serbia and Montenegro
Arthritis Res Ther 7:R1072-81. 2005..Different serological profiles could help in the differential diagnosis and adequate therapeutic approach to ANCA-positive ATD-treated patients with symptoms of systemic disease...
- Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agentsGustavo C Roman
University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA
J Neurol Sci 262:15-26. 2007..Other antithyroid agents include polychlorinated biphenyls (PCBs), perchlorates, mercury, and coal derivatives such as resorcinol, ..
- Association of iodine fortification with incident use of antithyroid medication--a Danish Nationwide StudyCharlotte Cerqueira
Research Centre for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
J Clin Endocrinol Metab 94:2400-5. 2009..Iodine-induced hyperthyroidism has been reported in the early phases of almost all iodine fortification programs, depending on prior iodine intake in the population, the amount of fortification, and the rate of change...
- Antithyroid drugs in the management of patients with Graves' disease: an evidence-based approach to therapeutic controversiesDavid S Cooper
Division of Endocrinology, Sinai Hospital of Baltimore, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21215, USA
J Clin Endocrinol Metab 88:3474-81. 2003
- Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytesC Crescioli
Department of Clinical Pathophysiology, University of Florence, Italy
J Endocrinol 195:145-55. 2007..Targeting T helper 1-mediated autoimmune thyroid disease with drugs that impair different intracellular pathways could be a novel pharmacological tool...
- HyperthyroidismDavid S Cooper
Division of Endocrinology, Sinai Hospital of Baltimore, Johns Hopkins University School of Medicine, MD 21215 5271, USA
Lancet 362:459-68. 2003..The more unusual causes of hyperthyroidism, including struma ovarii, thyrotropin-secreting tumours, choriocarcinoma, and amiodarone-induced thyrotoxicosis are, more often than not, a challenge to diagnose and treat...
- Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' diseaseHirotoshi Nakamura
Department of Internal Medicine II, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, Japan
J Clin Endocrinol Metab 92:2157-62. 2007..Although methimazole (MMI) and propylthiouracil (PTU) have long been used to treat hyperthyroidism caused by Graves' disease (GD), there is still no clear conclusion about the choice of drug or appropriate initial doses...
- The effects of amiodarone on the thyroidE Martino
Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Ospedale de Cisanello, Via Paradisa, 2, 56124 Pisa, Italy
Endocr Rev 22:240-54. 2001..Radioiodine therapy is usually not feasible due to the low thyroidal radioiodine uptake, while thyroidectomy can be performed in cases resistant to medical therapy, with a slightly increased surgical risk...
- The use of metabolomics for the discovery of new biomarkers of effectB van Ravenzwaay
BASF Aktiengesellschaft, Experimental Toxicology and Ecology, Z 470, D 67056 Ludwigshafen, Germany
Toxicol Lett 172:21-8. 2007..Though the extent of change was less than for tyrosine the consistent change of these metabolites is diagnostic for this (toxicological) mode of action...
- Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and concentration of seleniumVesna Bacic Vrca
Department of Clinical Pharmacy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia
Clin Chim Acta 341:55-63. 2004....
- Feasibility of the extended one-generation reproductive toxicity study (OECD 443)I Fegert
BASF SE, GUP PP Z470, D 67056 Ludwigshafen, Germany
Reprod Toxicol 34:331-9. 2012..These results illustrate the variety of reproductive and developmental endpoints which can be captured in this complex but manageable study design. Time constraints for triggering further (F2) testing are summarized...
- ThyrotoxicosisJayne A Franklyn
Centre for Diabetes, Endocrinology and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Lancet 379:1155-66. 2012..Total thyroidectomy is an option in selected cases. Future efforts are likely to concentrate on novel and safe ways to modulate the underlying disease process rather than stopping excess thyroid hormone production...
- Frequency of antineutrophil cytoplasmic antibody in Graves' disease patients treated with methimazoleMonica Guma
Rheumatology Section, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
J Clin Endocrinol Metab 88:2141-6. 2003..Our results suggest that BPI-positive patients tend to relapse with antithyroid medication...
- Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatmentFlorentia Kaguelidou
Institut National de la Santé et de la Recherche Médicale U690, Hopital Robert Debre, 75019 Paris, France
J Clin Endocrinol Metab 93:3817-26. 2008..There is debate about how Graves' disease (GD) should be treated in children...
- Age and gender predict the outcome of treatment for Graves' hyperthyroidismA Allahabadia
Division of Medical Sciences, University of Birmingham, Edgbaston, United Kingdom
J Clin Endocrinol Metab 85:1038-42. 2000....
- Pediatric Graves' disease: controversies in managementScott A Rivkees
Department of Pediatrics, Yale Pediatric Thyroid Center, Section of Developmental Biology and Endocrinology, Yale University School of Medicine, New Haven, CT, USA
Horm Res Paediatr 74:305-11. 2010..Thus the majority of pediatric patients with GD will need thyroidectomy or treatment with radioactive iodine (RAI; (131)I)...
- Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivoLars P Klieverik
Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Endocrinology 150:5639-48. 2009..The changes in whole-body lipid metabolism are accompanied by tissue-specific changes in TG-derived FA uptake in accordance with hyper- and hypometabolic states induced by thyrotoxicosis and hypothyroidism, respectively...
- Cholestasis secondary to hyperthyroidism made worse by methimazoleMohammed Majeed
Department of Internal Medicine, Memorial Hospital of Sweetwater County, Rocksprings, Wyoming, USA
Am J Med Sci 332:51-3. 2006..This case highlights the fact that worsening cholestasis after therapy for Graves disease should raise the possibility of thionamide-induced exaggeration of liver cholestasis...
- Central congenital hypothyroidism due to gestational hyperthyroidism: detection where prevention failedMarlies J E Kempers
Academic Medical Center, Emma Children s Hospital, Department of Pediatric Endocrinology, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
J Clin Endocrinol Metab 88:5851-7. 2003..A T(4)-based screening program appears useful in detecting this type of CCH. However, the preferential and presumably best strategy to prevent CCH caused by maternal Graves' disease is preserving euthyroidism throughout pregnancy...
- Treatment of hyperthyroidism in pregnancy and birth defectsMaurizio Clementi
Servizio di Informazione Teratologica, Genetica Clinica, Department of Pediatrics, University of Padova, Padova, Italy
J Clin Endocrinol Metab 95:E337-41. 2010..Clinical hyperthyroidism is not uncommon in pregnancy, with a reported prevalence of 0.1 to 0.4%. The available antithyroid drugs are propylthiouracil and methimazole/carbimazole...
- Antineutrophil cytoplasmic antibody-positive vasculitis in a patient with graves disease: cross-reaction between propylthiouracil and methimazoleKhulood Ahmed
Department of Internal Medicine, Texas Tech University Health Sciences Center, Odessa, Texas, USA
Endocr Pract 16:449-51. 2010..To alert clinicians about the risk of vasculitis and cross-reactivity of antithyroid medication...
- Perinuclear antineutrophil cytoplasmic antibody-associated vasculitis in a patient with Graves' disease treated with methimazoleDonna Bilu Martin
Department of Dermatology, University of Maryland Medical System, Baltimore, MD, USA
Skinmed 5:302-5. 2006..The patient underwent debridement of the thick, necrotic ulcerative eschars. To date, her lesions have resolved (Figure 4). An ANA drawn 5 months after withdrawal of MMI was negative, and p-ANCA was 1:67...
- The relation of initial methimazole dose to the incidence of methimazole-induced agranulocytosis in patients with Graves' diseaseKumiko Tsuboi
Division of Diabetes, Metabolism and Endocrinology, Department of Medicine, Toho University School of Medicine, Tokyo, Japan
Endocr J 54:39-43. 2007..31%) of 319 patients in the low-dose group (15 mg or lower) did. In conclusion, the incidence of agranulocytosis with low-dose MMI therapy was ten times lower than that of the high-dose regimen...
- Central nervous system vasculitis after starting methimazole in a woman with Graves' diseasePier Francesco Tripodi
Department of Internal Medicine, University of Messina, Messina, Italy
Thyroid 18:1011-3. 2008..Here we describe the first patient with central nervous system (CNS) vasculitis that developed shortly after the start of methimazole (MMI) treatment for GD...
- Methimazole-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and lupus-like syndrome with a cutaneous feature of vesiculo-bullous systemic lupus erythematosusHaw Yueh Thong
Acta Derm Venereol 82:206-8. 2002
- [Relationship between methimazole and antineutrophil cytoplasmic antibody-positive vasculitis]Lin qi Chen
Children s Hospital Affiliated to Suzhou University, Suzhou 215000, China
Zhonghua Er Ke Za Zhi 46:446-9. 2008..To study the relationship between methimazole (MMI) and antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis...
- Retrospective analysis of 18 cases of antithyroid drug (ATD)-induced agranulocytosisWei xin Dai
Endocrinology Department, Chinese Academy Medicine Sciences, Peking Union Medical College Hospital, Beijing, P R of China
Endocr J 49:29-33. 2002..In this series of patients, treatment with granulocyte-macrophage colony stimulating factor (GM-CSF) increased the granulocyte counts, whereas the effectiveness of glucocorticoid treatment was not confirmed...
- Methimazole-induced antineutrophil cytoplasmic antibody-associated diffuse alveolar haemorrhage in a Chinese woman with Graves' diseaseEmmy Y F Lau
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong
Hong Kong Med J 15:209-12. 2009..Diffuse alveolar haemorrhage is a rare complication of thiourea agents and the treatment often requires corticosteroids or other immunosuppressants, together with withdrawal of the causative agent...
- Graves' disease in childhood: advances in management with antithyroid drug therapyFlorentia Kaguelidou
Pediatric Endocrinology Department, Centre de Référence Maladies Endocriniennes de la Croissance, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Universite Paris VII, Paris, France
Horm Res 71:310-7. 2009..Long-term careful follow-up is needed to determine the efficacy of disease management during childhood...
- Dissimilar hepatotoxicity profiles of propylthiouracil and methimazole in childrenScott A Rivkees
Yale Pediatric Thyroid Center, Section of Developmental Endocrinology and Biology, Yale University, 464 Congress Avenue, New Haven, CT 06520, USA
J Clin Endocrinol Metab 95:3260-7. 2010..To date, there has not been a systematic and comparative evaluation of the adverse events associated with antithyroid drug use...
- Analytic review: thyrotoxic periodic paralysis: a reviewPooja Pothiwala
Department of Medicine, Section of Endocrinology and Metabolism, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA
J Intensive Care Med 25:71-7. 2010..Correction of hypokalemia and the underlying thyrotoxic state usually results in amelioration of the acute attack. This review summarizes the epidemiology, clinical manifestations, pathogenesis, diagnosis, and treatment of TPP...
- Serum concentrations of granulocyte colony-stimulating factor (G-CSF) in antithyroid drug-induced agranulocytosisYasuhiro Murakami
Comprehensive Medical Center for Health, Otemae Hospital, Osaka 584 0008, Japan
Endocr J 51:579-85. 2004....
- Thyrotoxic hypokalemic periodic paralysis triggered by high carbohydrate dietAdel S El-Hennawy
Nephrology and Dialysis Center, Department of Medicine, Renal Division, Coney Island Hospital, Brooklyn, NY, USA
Am J Ther 14:499-501. 2007....
- Juvenile thyrotoxicosis; can we do better?G Birrell
Department of Paediatrics, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
Arch Dis Child 89:745-50. 2004..Even "definitive" treatment will typically necessitate thyroxine replacement for life...
- Epitope heterogeneity of thyroid-stimulating antibodies predicts long-term outcome in Graves' patients treated with antithyroid drugsTae Yong Kim
Department of Internal Medicine, Seoul National University College of Medicine and Clinical Research Institute, Seoul National University Hospital, Seoul 110 744, Korea
J Clin Endocrinol Metab 88:117-24. 2003....
- Antithyroid drug-induced immunomodulation in Graves' disease patientsMirna Lechpammer
Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital, Vinogradska 29, HR 10000 Zagreb, Croatia
Acta Med Croatica 56:21-6. 2002..Study results strongly support the hypothesis of a direct immunosuppressive effect of methimazole in patients with Graves' disease rather than the theory favoring concomitant immunomodulation due to thyroid hormone decrease...
- Iridic and retinal coloboma associated with prenatal methimazole exposureMichihiko Aramaki
Am J Med Genet A 139:156-8. 2005
- Pharmacokinetics and pharmacotherapy of thionamides in pregnancyShannon M Clark
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
Ther Drug Monit 28:477-83. 2006..None of the above have been substantiated in more recent studies. The pharmacokinetics of the thionamides in the pregnant and nonpregnant states, as well as the pharmacotherapeutic recommendation for hyperthyroidism will be reviewed...
- Thyrotoxic hypokalemic periodic paralysis in a Turkish male with graves' disease: a rare case report and review of the literatureCihangir Erem
Department of Internal Medicine, Division of Endocrinology and Metabolism, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
Endocrine 27:63-5. 2005..He had no further episodes of hypokalemic paralysis. To the best of the author's knowledge, and after a Medline search, THPP has not been described previously in a Turkish man...
- Therapeutic drug monitoring of antithyroid drugs in pregnancy: the knowledge gapsGideon Koren
Department of Medicine, Division of Endocrinology and Metabolism, Lombardi Cancer Center
Ther Drug Monit 28:12-3. 2006..This knowledge gap must be filled to ensure fetal safety...
- Graves' hyperthyroidism: how long should antithyroid drug therapy be continued to achieve remission?Anthony P Weetman
Medical School, University of Sheffield, UK
Nat Clin Pract Endocrinol Metab 2:2-3. 2006
- Higher dose of methimazole causes frequent adverse effects in the management of Graves' disease in children and adolescentsHirokazu Sato
Nakayama Medical Square, Chiba, Japan
J Pediatr Endocrinol Metab 25:863-7. 2012..The aim of this study was to evaluate the correlation between the initial dose of MMI and the clinical course of GD after treatment...
- Thyrotoxicosis and paraparesis in a young woman: case report and review of the literatureGunnar Mellgren
Department of Internal Medicine, University of Bergen, Haukeland Hospital, Norway
Thyroid 12:77-80. 2002..With increasing immigration, TPP is likely to occur more frequently in both Europe and North America and awareness of the condition is vital. Treatment of the underlying thyroid dysfunction cures the muscle symptoms...
- Treatment of Graves' hyperthyroidism: evidence-based and emerging modalitiesLaszlo Hegedus
Department of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, Odense, Denmark
Endocrinol Metab Clin North Am 38:355-71, ix. 2009..Prospective, randomized studies comparing available and any novel therapeutic options for GD are needed. The focus of these studies should include, but not be limited to, cost and quality of life...
- Hypothyroidism reduces glutamate-synaptic release by ouabain depolarization in rat CA3-hippocampal regionK B Sánchez-Huerta
Departamento de Fisiología Mauricio Russek, Escuela Nacional de Ciencias Biologicas, IPN, Mexico D F, Mexico
J Neurosci Res 90:905-12. 2012....
- Positive impact of long-term antithyroid drug treatment on the outcome of children with Graves' disease: national long-term cohort studyJuliane Leger
Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Service d endocrinologie pédiatrique, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, INSERM Unité 676, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
J Clin Endocrinol Metab 97:110-9. 2012..Drug-based therapy is usually the initial treatment for Graves' disease (GD) hyperthyroidism in children, but there is some debate about treatment duration...
- Antithyroid drug-induced fetal goitrous hypothyroidismSofie Bliddal
Department of Medical Endocrinology, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
Nat Rev Endocrinol 7:396-406. 2011..The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T(4) levels...
- Elevated serum IL-16 and RANTES levels in patients with autoimmune thyroid diseases and modulation by methimazole therapyX Gu
Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou City, Zhejiang Province, P R China
Horm Metab Res 44:482-7. 2012..In conclusion, IL-16 and RANTES might be involved in the pathogenesis of GD and HT, and serum IL-16 levels in GD maybe a potential marker of disease activity and severity...
- Management of Graves' disease during pregnancy: the key role of fetal thyroid gland monitoringDominique Luton
Department of Perinatology, Multidisciplinary Center for Prenatal Diagnosis, Robert Debre Hospital, 75019 Paris, France
J Clin Endocrinol Metab 90:6093-8. 2005..Early diagnosis is essential to successful management. We investigated a new approach to the fetal diagnosis of thyroid dysfunction and validated the usefulness of fetal thyroid ultrasonograms...
- Pediatric Graves' disease: outcome and treatmentLaura Gruneiro-Papendieck
Division de Endocrinologia, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
J Pediatr Endocrinol Metab 16:1249-55. 2003..Graves' disease treatment in children and adolescents includes antithyroid drugs (ATD), 131I (RI) or subtotal thyroidectomy (CX), all of which present beneficial effects and disadvantages...
- Pulmonary hypertension in men with thyrotoxicosisArdeshir Soroush-Yari
Pulmonary and Critical Care Section, Department of Medicine, VA Greater Los Angeles Healthcare System, UCLA School of Medicine, Los Angeles, Calif, USA
Respiration 72:90-4. 2005..Recognition is important since treatment and response are very different compared to other patients with pulmonary hypertension. This association may not be readily considered in men, since most reports have been of women...
- Clinical review: Thyrotoxic periodic paralysis: a diagnostic challengeAnnie W C Kung
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
J Clin Endocrinol Metab 91:2490-5. 2006..The aim of this article was to review the clinical presentation, pathogenesis, and management of thyrotoxic periodic paralysis (TPP)...
- Predictors of outcome and comparison of different drug regimens for the prevention of relapse in patients with Graves' diseaseBjorn G Nedrebo
Division of Endocrinology, Department of Internal Medicine, University of Bergen, Bergen, Norway
Eur J Endocrinol 147:583-9. 2002..To investigate the effect of different antithyroid drug (ATD) regimens on relapse rates of Graves' disease, and to look for predictors of relapse...
- Choanal atresia associated with maternal hyperthyroidism treated with methimazole: a case-control studyPablo Barbero
Centro Nacional de Genetica Medica, ANLIS, Ministerio de Salud, Buenos Aires, Argentina
Am J Med Genet A 146:2390-5. 2008..In addition, based on our cases and a critical literature review, we propose that the mother's disease might be the causal factor and not the MMI treatment...
- Prevalence of positive anti-neutrophil cytoplasmic antibody (ANCA) in patients receiving anti-thyroid medicationJ E Gunton
Department of Endocrinology, Royal North Shore Hospital, St Leonards, Sydney, Australia
Eur J Endocrinol 142:587. 2000....
- Remission of Graves' disease during anti-thyroid drug therapy. Time to reconsider the mechanism?Peter Laurberg
Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, DK 9000 Aalborg, Denmark
Eur J Endocrinol 155:783-6. 2006..The conclusion that remission is associated with restoration of the euthyroid state, and that it is not a special drug effect, highlights the importance of making and keeping patients with Graves' disease euthyroid...
- Choanal atresia associated with prenatal methimazole exposure: three new patientsP Barbero
Centro Nacional de Genetica Medica, Buenos Aires, Argentina
Am J Med Genet A 129:83-6. 2004..At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus...
- Elevated CD69 expression on naive peripheral blood T-cells in hyperthyroid Graves' disease and autoimmune thyroiditis: discordant effect of methimazole on HLA-DR and CD69A Gessl
Department of Medicine III, University of Vienna, Austria
Clin Immunol Immunopathol 87:168-75. 1998..These data suggest association of HLA-DR expression with ongoing autoimmunity, while increased CD69 expression relates in part also to elevated thyroid hormone concentration in GDH...
- Extrathyroidal actions of antithyroid thionamidesUday Bandyopadhyay
Department of Physiology, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Calcutta 700 032, India
Toxicol Lett 128:117-27. 2002..Thionamides also affect gene expression and modulate the functions of some cell types. A brief account of the chemistry and metabolism of antithyroid thionamides, along with their biological actions are presented...
- The treatment of Graves' disease in childrenScott A Rivkees
Yale Pediatric Thyroid Center, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
J Pediatr Endocrinol Metab 19:1095-111. 2006..Definitive therapy in the form of surgery or radioactive iodine is necessary and unavoidable for the majority of pediatric patients with Graves' disease...
- Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomesZ Guo
Department of Drug Metabolism and Pharmacokinetics, Rhone Poulenc Rorer, Collegeville, PA 19426, USA
Drug Metab Dispos 25:390-3. 1997..This study indicates orphenadrine cannot be used as a selective inhibitor of CYP2B6 in human liver microsomes and that methimazole is not a selective inhibitor of the flavin-containing monooxygenase in human liver microsomes...
- Management of Graves' hyperthyroidism in pregnancy: focus on both maternal and foetal thyroid function, and caution against surgical thyroidectomy in pregnancyPeter Laurberg
Department of Endocrinology and Medicine, Aalborg Hospital, Aalborg, Denmark
Eur J Endocrinol 160:1-8. 2009..Surgical thyroidectomy of a pregnant woman with active disease may lead to isolated foetal hyperthyroidism...
- Carbimazole embryopathy: an emerging phenotypeNicola Foulds
SW Thames Regional Genetics Services, St George s Hospital, London, UK
Am J Med Genet A 132:130-5. 2005..The phenotype associated with exposure to carbimazole appears to be rare but specific with distinctive facial features. We report on two new cases of carbimazole embryopathy with strikingly similar facial features...
- Diagnosis and treatment of Graves diseaseDarcie D Streetman
University of Michigan Health Systems, University of Michigan, Ann Arbor, MI, USA
Ann Pharmacother 37:1100-9. 2003..Specifically, antithyroid drugs, beta-blockers, inorganic iodide, lithium, and radioactive iodine are discussed, focusing on current controversies...
- Thyroid function in wholly breast-feeding infants whose mothers take high doses of propylthiouracilN Momotani
Ito Hospital, Tokyo, Japan
Clin Endocrinol (Oxf) 53:177-81. 2000..However, there are virtually no data on the effects of maternal PTU on thyroid status of infants whose mothers take more than 300 mg PTU daily and who are wholly breast-feeding...
- Treatment options for Graves disease: a cost-effectiveness analysisHaejin In
Department of Surgery, Boston Medical Center, 88 East Newton St, C515, Boston, MA 02118, USA
J Am Coll Surg 209:170-179.e1-2. 2009..We aim to determine the most cost-effective option...
- Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxineSofie Bliddal
Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen University, Copenhagen, Denmark
Thyroid 21:75-81. 2011..Treatment of Graves' disease during pregnancy with antithyroid drugs (ATDs) poses a risk of inducing hypothyroidism and, thus, development of a goiter to the fetus...
- Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UKSimon H S Pearce
School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
Clin Endocrinol (Oxf) 61:589-94. 2004..To determine the frequency and spectrum of serious adverse drug reactions (ADRs) to thionamide antithyroid drugs...
- Therapy insight: management of Graves' disease during pregnancyGrace W Chan
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Nat Clin Pract Endocrinol Metab 3:470-8. 2007..Neonatal thyrotoxicosis can occur in the first few days of life after clearance of maternal antithyroid drug, and can last for several months, until maternal antibodies are also cleared...
- Methimazole-induced hepatotoxicityKenneth A Woeber
Department of Medicine, University of California, San Franscisco, California 94143 1640, USA
Endocr Pract 8:222-4. 2002..To present the case of a patient with Graves' hyperthyroidism in whom treatment with methimazole led to severe cholestasis...
- [Characterization of therapy failures in radioiodine therapy of Graves' disease without simultaneous antithyroid agents]O Sabri
Nuklearmedizin 40:1-6. 2001..It should be noted, though, that 5 therapy failures (2.2%) reached an absorbed energy dose of > 250 Gy...
- Effect of hypothyroidism on beta-adrenoceptor-mediated relaxation in the rat thoracic aortae. A time-dependent studyBeryl Ampong
Department of Pharmacology, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 193 0392, Japan
Vascul Pharmacol 38:149-55. 2002....
- Adult-onset hypothyroidism impairs paired-pulse facilitation and long-term potentiation of the rat dorsal hippocampo-medial prefrontal cortex pathway in vivoL Sui
Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, Shanghai, PR China
Brain Res 1096:53-60. 2006..The results suggest that such alterations in synaptic plasticity of the dorsal hippocampo-mPFC pathway might contribute to understanding basic mechanisms underlying learning and memory deficits associated with adult-onset hypothyroidism...
- Methimazole-induced cholestatic jaundiceNasser E Mikhail
Division of Endocrinology, Department of Medicine, Olive View UCLA Medical Center, Sylmar, CA 91342 1495, USA
South Med J 97:178-82. 2004..Physicians and patients should be aware of this adverse effect so that, upon occurrence, they can discontinue methimazole therapy and avoid unnecessary invasive procedures...
- Effects of thyroid hormones on cardiac structure: a tissue characterization study in patients with thyroid disorders before and after treatmentM M Ciulla
Institute of Internal Medicine, Centro di Fisiologia Clinica e Ipertensione, University of Milan, Ospedale Maggiore Policlinico IRCCS, Italy
Thyroid 11:613-9. 2001....
- Thyroid hormones affect the level and activity of nitric oxide synthase in rat cerebral cortex during postnatal developmentZoltan Serfozo
Department of Experimental Zoology, Balaton Limnological Research Institute, Hungarian Academy of Sciences, Klebelsberg Kuno u 3, Tihany 8237, Hungary
Neurochem Res 33:569-78. 2008..Our findings indicate that abnormal TH levels differentially regulate the activity and the level of nNOS and suggest a cross-talk between the TH and NO signaling pathway in the developing cerebral cortex of rats...
- Therapeutic plasmapheresis in patients with severe hyperthyroidism in whom antithyroid drugs are contraindicatedN Ozbey
Division of Endocrinology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Int J Clin Pract 58:554-8. 2004..However, this is an invasive procedure and patients should be followed carefully for prolonged clinic/subclinic coagulopathy due to plasma exchange...
- Fulminant hepatic failure associated with propylthiouracil: a case report with treatment emphasis on the use of plasmapheresisSelim Aydemir
Department of Gastroenterology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
J Clin Apher 20:235-8. 2005..Here we report a case of fulminant hepatic failure due to propylthiouracil and review the issues of treatment and management with special emphasis on the use of plasmapheresis in such situations...
- 2'3'Cyclic nucleotide 3'phosphodiesterase immunohistochemistry shows an impairment on myelin compaction in hypothyroid ratsP C Barradas
Depto Farmacologia e Psicobiologia, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
Int J Dev Neurosci 18:887-92. 2000..Thus, our data suggest a disorder in myelin compaction and point once more to the post-natal period as critical for the mechanisms that are thyroid hormone regulated in myelinogenesis...
- Hypothyroidism induces selective oxidative stress in amygdala and hippocampus of ratEdgar Cano-Europa
Departamento de Fisiología Mauricio Russek, Escuela Nacional de Ciencias Biologicas, IPN, Prol Carpio y Plan de Ayala, S N, cp 11340 Mexico City, Mexico
Metab Brain Dis 23:275-87. 2008..Results show that hypothyroidism induces selective oxidative stress in both the hippocampus and amygdala, where the nitrergic system is involved...
- Effects of hypothyroidism induced by perinatal exposure to PTU on rat behavior and synaptic gene expressionKumiko Kobayashi
Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
Toxicology 212:135-47. 2005....
- Prevalence of serum anti-myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves' disease treated with propylthiouracil and thiamazoleNorio Wada
Division of Endocrinology and Metabolism, Department of Medicine, Sapporo City General Hospital, Kita 11, Nishi 13, Chuo Ku, Sapporo 060 8604, Japan
Endocr J 49:329-34. 2002..Thus, there is a high frequency of MPO-ANCA in patients with Graves' disease treated with PTU, compared with patients treated with MMI, although classical ANCA-associated vasculitis develops in only a few MPO-ANCA positive patients...
- Propylthiouracil and carbimazole associated-antineutrophil cytoplasmic antibodies (ANCA) in patients with Graves' diseaseL Harper
Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, UK
Clin Endocrinol (Oxf) 60:671-5. 2004..We aimed to investigate whether carbimazole therapy was also associated with increased risk of ANCA...
- Impairment in short-term but enhanced long-term synaptic potentiation and ERK activation in adult hippocampal area CA1 following developmental thyroid hormone insufficiencyL Sui
National Research Council, Washington, DC 20001, USA
Toxicol Sci 85:647-56. 2005..Such alterations in hippocampal synaptic function may contribute to persistent behavioral deficits associated with developmental hypothyroidism...
- A case of propylthiouracil-induced pyoderma gangrenosum associated with antineutrophil cytoplasmic antibodySeok Beom Hong
Department of Dermatology, College of Medicine, Kyunghee University, Seoul, Korea
Dermatology 208:339-41. 2004..The authors think that propylthiouracil is associated with the occurrence of pyoderma gangrenosum in this patient...
- Effect of PTU on IL-12 and IL-10 in psoriasisAlan N Elias
Department of Medicine Endocrinology and Dermatology, University of California, Irvine, Irvine, California, USA
J Drugs Dermatol 2:645-8. 2003..It is speculated that the beneficial effect is likely mediated by an inhibitory effect on keratinocyte proliferation or promotion of apoptosis in these proliferated keratinocytes...
- Antioxidant potential of propylthiouracil in patients with psoriasisSerap Utas
Erciyes University, School of Medicine, Department of Dermatology
Clin Biochem 35:241-6. 2002....
- Propylthiouracil-induced lupus-like syndrome developing in a Graves' patient with a sibling with systemic lupus erythematosusAkemi Yamada
Institute of Clinical Endocrinology, Tokyo Women s Medical University, Tokyo
Intern Med 41:1204-8. 2002..Both patients had the identical HLA-DR alleles (HLA-DR9). These present two cases in siblings suggest that both sisters had lupus diathesis, and that the elder sister developed a PTU-induced lupus-like syndrome...
- Drug-induced neutropenia associated with anti-neutrophil cytoplasmic antibodies (ANCA): possible involvement of complement in granulocyte cytotoxicityT Akamizu
Department of Medicine and Clinical Science, Kyoto Universoty Graduate School of Medicine, Japan
Clin Exp Immunol 127:92-8. 2002..These findings suggest that ANCA induced by propylthiouracil contributed to leucopenia through a complement-mediated mechanism...
- Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patientsCesare Carani
Department of Endocrinology, University of Modena, Italy
J Clin Endocrinol Metab 90:6472-9. 2005..Thyroid hormones have a dramatic effect on human behavior. However, their role on sexual behavior and performance has seldom been investigated in men...
- Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves' hyperthyroidismChih Tsueng He
Division of Endocrinology and Metabolism, Department of Medicine, Tri Service General Hospital, National Defense Medical Centre, Taipei, Taiwan
Clin Endocrinol (Oxf) 60:676-81. 2004..The present study was to compare the efficacy of a single daily dose of methimazole (MMI) and propylthiouracil (PTU) in the treatment of Graves' hyperthyroidism...
- Antithyroid drugsBernard Goichot
N Engl J Med 352:2246-7; author reply 2246-7. 2005
- Effective methimazole dose for childhood Graves' disease and use of free triiodothyronine combined with concurrent thyroid-stimulating hormone level to identify mild hyperthyroidism and delayed pituitary recoveryArnold H Slyper
Department of Pediatrics, Loyola University Medical Center, Maywood, IL 60153, USA
J Pediatr Endocrinol Metab 18:597-602. 2005..Free T3 levels combined with concurrent TSH levels permit differentiation of mild hyperthyroidism from delayed pituitary recovery...
- Susceptible alleles of the CD40 and CTLA-4 genes are not associated with the relapse after antithyroid withdrawal in Graves' diseaseKyung Won Kim
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Thyroid 17:1229-34. 2007..These findings suggest that the genetic markers associated with the development of GD cannot be used to predict the relapse of GD patients in place of clinical parameters...
- Use of anti-thyroid drugs in euthyroid pregnant women with previous Graves' diseaseTammy McNab
Department of Medicine, Division of Endocrinology, University of Alberta, Edmonton, AB, Canada
Clin Invest Med 28:127-31. 2005....
- Successful intrauterine therapy for fetal goitrous hypothyroidism during late gestationIchiro Miyata
Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
Endocr J 54:813-7. 2007..This case indicates that intrauterine therapy by the intraamniotic administration of L-T(4) can be effective in treating fetal goitrous hypothyroidism even during late gestation...
- Ambulatory blood pressure monitoring in patients with hyperthyroidism before and after control of thyroid functionP Iglesias
Department of Endocrinology, Hospital General, Segovia, Spain
Clin Endocrinol (Oxf) 63:66-72. 2005..Our aims were (1) to analyse ABPM in a group of normotensive hyperthyroid patients before and after normalizing circulating thyroid hormones and (2) to compare these results with those obtained in a group of euthyroid subjects...
- The use of konjac glucomannan to lower serum thyroid hormones in hyperthyroidismAdil Dogan Azezli
Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology Metabolism and Nutrition, Fatih Istanbul, Turkey
J Am Coll Nutr 26:663-8. 2007....
- The effect of anti-thyroid drug treatment duration on thyroid gland microvessel density and intraoperative blood loss in patients with Graves' diseaseYesim Erbil
Istanbul Medical Faculty, Department of General Surgery, Istanbul University, Turkey
Surgery 143:216-25. 2008..We aimed to evaluate thyroid blood flow and microvessel density in patients with GD according to antithyroid drug (ATD) treatment, preoperatively...
- GRAVES' DISEASE STUDIESDavid Solomon; Fiscal Year: 1980..From all of these observations, it may be possible to choose among current hypotheses as to the pathogenesis of hyperthyroidism in Graves' disease...
- CHEMICAL AND ENZYMIC MECHANISM OF THIOCARBAMIDE TOXICITYDaniel Doerge; Fiscal Year: 1990..This research will correlate the enzymology of thiocarbamide metabolism with the chemistry of putative reactive intermediates to define toxicological mechanisms and health hazards of this significant class of environmental chemicals...
- Anti-Adenosine Therapy of Neonatal Brain InjuryScott Rivkees; Fiscal Year: 2007..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
- Radioactive Iodide Therapy of Pediatric Graves' DiseaseScott A Rivkees; Fiscal Year: 2010....
- CB1 Receptor Action on the Developing HippocampusScott Rivkees; Fiscal Year: 2005..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
- Adenosinergic Mechanisms of Intrauterine Growth RetardationScott A Rivkees; Fiscal Year: 2010..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..
- A-1 Adenosine Receptor Action in Developing HeartScott Rivkees; Fiscal Year: 2005..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
- The Role of Adenosine in Hypoglycemic Brain InjuryScott Rivkees; Fiscal Year: 2003..We anticipate that these studies will yield new insights into the mechanisms of hypoglycemic brain injury and may lead to the development of practical strategies for reducing hypoglycemic brain injury. ..
- Vaccine therapy of congenital adrenal HyperplasiaScott Rivkees; Fiscal Year: 2003..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
- A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUSScott Rivkees; Fiscal Year: 2003..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
- DEVELOPING CIRCADIAN RHYTHMICITYScott Rivkees; Fiscal Year: 2002..These studies may also lead to the development of new care practices in Neonatal Intensive Care Units and extend the field of developmental chronobiology to the bedside. ..
- Nitogen reduction and xenobiotic responseLauren A Trepanier; Fiscal Year: 2010..The ultimate goal of these studies is to find better ways to prevent these adverse reactions. ..
- Retinal Oxygenation in Diabetic RetinopathyBRUCE BERKOWITZ; Fiscal Year: 2004..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
- Cardiovascular Consequences of Thyroid DysfunctionElizabeth Pearce; Fiscal Year: 2007..Pearce's career as an independent academic clinical investigator with a focus on thyroid disease and epidemiology. ..
- MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITYBRUCE BERKOWITZ; Fiscal Year: 2001..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
- Developmental Neuroendocrine Effects of PCBs and PBDEs: Parallels with ADHDRICHARD FIELD SEEGAL; Fiscal Year: 2010....
- ADVANCES IN SELENIUM SUPPLEMENTATIONMichael Franklin; Fiscal Year: 2006..abstract_text> ..
- EYE IN GRAVES DISEASE--ROLE OF ORBITAL FIBROBLASTSRebecca Bahn; Fiscal Year: 2004..The main goal of the research program is to increase understanding of the orbital immune response in GO in order that novel and more specific therapeutic and preventive strategies for this condition might be developed. ..
- Manganese-enhanced MRI Studies of Retinal NeovascularizationBRUCE BERKOWITZ; Fiscal Year: 2008..The novel methods in this application will also contribute to the advancement of functional MRI for the study of retinal diseases. [unreadable] [unreadable] [unreadable]..
- Cerebral edema in pediatric ketoacidosisNicole Glaser; Fiscal Year: 2009..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
- Thyrotropin Receptor Auto Antibodies in Graves' OphthalmopathyRebecca S Bahn; Fiscal Year: 2010..Our studies will yield information concerning mechanisms involved in disease development, and will determine the effectiveness of a novel approach to therapy. ..
- Genital Ulcer Disease and HIV TransmissionJeanne Sheffield; Fiscal Year: 2005..The pursuit of these aims will further elucidate the cellular and molecular bases of the interrelationship between GUD and HIV-1 transmission, particularly in women. ..
- PCB-Induced Inflammation and Nigral Dopamine LossRichard Seegal; Fiscal Year: 2005..abstract_text> ..
- Thyroid Hormone Receptor Isoform-Specific ActionsGregory Brent; Fiscal Year: 2008..abstract_text> ..
- Immune Thrombocytopenia and Low-Level Mercury ExposureJodi Segal; Fiscal Year: 2006..Segal with the necessary support for successful completion [unreadable] [unreadable] [unreadable]..
- Mentored Patient-Oriented Research Career Development AwardJacqueline Jonklaas; Fiscal Year: 2006..A new sustained release product, which results in steady triiodothyronine levels, will furnish more physiologic replacement. This will be tested against treatment with levothyroxine, and levothyroxine and triiodothyronine. ..
- Thyrocytes Express Inflammatory MediatorsAndrew Gianoukakis; Fiscal Year: 2006..The candidate will develop the scientific knowledge base, problem solving abilities, and technical skills which will allow him to develop into a independent physician/scientiist. ..