antisense oligodeoxyribonucleotides

Summary

Summary: Short fragments of DNA that are used to alter the function of target RNAs or DNAs to which they hybridize.

Top Publications

  1. ncbi Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies
    Anatoly Dritschilo
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20007
    Clin Cancer Res 12:1251-9. 2006
  2. ncbi Tumor-selective targeted delivery of genes and antisense oligodeoxyribonucleotides via the folate receptor
    Xiaobin B Zhao
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Room 542, LM Parks Hall, 500 W 12th Avenue, Columbus, OH 43210, USA
    Adv Drug Deliv Rev 56:1193-204. 2004
  3. ncbi Treatment of Streptococcus mutans with antisense oligodeoxyribonucleotides to gtfB mRNA inhibits GtfB expression and function
    Qing yu Guo
    Department of Oral Biology, College of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    FEMS Microbiol Lett 264:8-14. 2006
  4. ncbi Synthesis of light-activated antisense oligodeoxynucleotide
    XinJing Tang
    Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
    Nat Protoc 1:3041-8. 2006
  5. ncbi Effective targeted gene 'knockdown' in zebrafish
    A Nasevicius
    Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota, USA
    Nat Genet 26:216-20. 2000
  6. ncbi Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways
    Zsuzsanna S Nagy
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 77030, USA
    J Leukoc Biol 72:819-28. 2002
  7. pmc Regulating gene expression in human leukemia cells using light-activated oligodeoxynucleotides
    XinJing Tang
    The Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucleic Acids Res 36:559-69. 2008
  8. pmc Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNA
    S Patrick Walton
    Center for Engineering in Medicine Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital, Boston, Massachusetts 02114, USA
    Biophys J 82:366-77. 2002
  9. ncbi Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1
    K A Carnevale
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 167:3414-21. 2001
  10. pmc Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules
    J B Opalinska
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nucleic Acids Res 32:5791-9. 2004

Research Grants

  1. Targeted Lipopolyplexes for Oligonucleotide Delivery to AML
    Robert J Lee; Fiscal Year: 2012
  2. SOMATOSTATIN RECEPTORS--CLASSIFICATION OF NEUROBLASTOMAS
    M O DORISIO; Fiscal Year: 1999
  3. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2006
  4. INTERLEUKIN 13 STIMULATION OF HUMAN MONOCYTES
    MARTHA CATHCART; Fiscal Year: 2002
  5. ONTOGENY AND EXPRESSION OF THE CFTR IN BRAIN
    ANDREW MULBERG; Fiscal Year: 2003
  6. COMPARATIVE ANALYSIS OF CLOCK GENES
    STEVEN REPPERT; Fiscal Year: 2001
  7. Examing Oligonucleotide Effects on Gene Expression
    Alan Gewirtz; Fiscal Year: 2007
  8. Developing Nucleic Acid Therapeutics
    Alan Gewirtz; Fiscal Year: 2007
  9. A Metabolomic Approach to Discovering Biomarkers for ADPKD
    Robert H Weiss; Fiscal Year: 2010
  10. Reactive astrocytes from gliotic capsule
    J Marc Simard; Fiscal Year: 2007

Detail Information

Publications228 found, 100 shown here

  1. ncbi Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies
    Anatoly Dritschilo
    Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20007
    Clin Cancer Res 12:1251-9. 2006
    ..In this dose escalation study, we evaluated the safety of combined liposomal formulation of raf antisense oligonucleotide (LErafAON) and radiation therapy in patients with advanced malignancies...
  2. ncbi Tumor-selective targeted delivery of genes and antisense oligodeoxyribonucleotides via the folate receptor
    Xiaobin B Zhao
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Room 542, LM Parks Hall, 500 W 12th Avenue, Columbus, OH 43210, USA
    Adv Drug Deliv Rev 56:1193-204. 2004
    ..In addition, FR-targeted liposomes have been evaluated for the targeted delivery of antisense oligodeoxyribonucleotides (ODNs)...
  3. ncbi Treatment of Streptococcus mutans with antisense oligodeoxyribonucleotides to gtfB mRNA inhibits GtfB expression and function
    Qing yu Guo
    Department of Oral Biology, College of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    FEMS Microbiol Lett 264:8-14. 2006
    We examined the effects of phosphorothioate-modified antisense oligodeoxyribonucleotides (PS-ODN) targeted to mRNA transcribed from gtfB, which encodes synthesis of water-insoluble glucans in Streptococcus mutans. Treatment of S...
  4. ncbi Synthesis of light-activated antisense oligodeoxynucleotide
    XinJing Tang
    Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
    Nat Protoc 1:3041-8. 2006
    ..Here, we provide a detailed procedure for synthesizing photoactive asODNs in good yields. Synthesis, purification and analysis of the light-activated asODN can be completed within 1-2 weeks...
  5. ncbi Effective targeted gene 'knockdown' in zebrafish
    A Nasevicius
    Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota, USA
    Nat Genet 26:216-20. 2000
    ..Conserved vertebrate processes and diseases are now amenable to a systematic, in vivo, reverse-genetic paradigm using zebrafish embryos...
  6. ncbi Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways
    Zsuzsanna S Nagy
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 77030, USA
    J Leukoc Biol 72:819-28. 2002
    ..We conclude that IL-2 family cytokines tightly control Stat5 serine phosphorylation through a kinase distinct from the Stat3 serine kinase...
  7. pmc Regulating gene expression in human leukemia cells using light-activated oligodeoxynucleotides
    XinJing Tang
    The Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucleic Acids Res 36:559-69. 2008
    ..Two-fold photomodulation of c-MYB protein levels was also observed with S-C5. However, no photomodulation of c-MYB protein levels was observed with S-C6, perhaps due to the greater stability of this duplex...
  8. pmc Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNA
    S Patrick Walton
    Center for Engineering in Medicine Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Burns Hospital, Boston, Massachusetts 02114, USA
    Biophys J 82:366-77. 2002
    ..Implications for the rational design of effective antisense reagents are discussed...
  9. ncbi Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1
    K A Carnevale
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 167:3414-21. 2001
    ..These data demonstrate novel and distinct roles for these two phospholipases in this critical step in inflammation...
  10. pmc Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules
    J B Opalinska
    Division of Hematology Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nucleic Acids Res 32:5791-9. 2004
    ..We conclude that rationally targeted, OXE modified ODNs, can function efficiently as gene silencing agents, and hypothesize that they will prove useful for therapeutic purposes...
  11. ncbi Developmental, molecular, and genetic dissection of INa in vivo in embryonic zebrafish sensory neurons
    Ricardo H Pineda
    Department of Physiology and Biophysics, Mail Stop 8307, University of Colorado Health Sciences Center at Fitzsimons, P O Box 6511, Aurora, CO 80045, USA
    J Neurophysiol 93:3582-93. 2005
    ..Finally, analysis of macho mutants indicated that developmental upregulation of INa was absent in RB cells. These results indicate that MOs are a useful tool for the molecular dissection and analysis of ion channel function in vivo...
  12. pmc Identification of antisense nucleic acid hybridization sites in mRNA molecules with self-quenching fluorescent reporter molecules
    Lida K Gifford
    Department of Chemistry, School of Arts and Sciences 231 South 34th Street, Philadelphia, PA 19104, USA
    Nucleic Acids Res 33:e28. 2005
    ..The general utility of this method is demonstrated by SQRM identification of targetable sequence within c-myb and bcl-6 mRNA. Corresponding antisense oligonucleotides reduce these gene products in cells...
  13. ncbi Multigene targeting with antisense oligodeoxynucleotides: an exploratory study using primary human leukemia cells
    Joanna B Opalinska
    Authors Affiliations Hematology and Pathology, Pommeranian Medical University, Szczecin, Poland
    Clin Cancer Res 11:4948-54. 2005
    ..Because the expression of these genes is not known to be linked, we sought to determine the therapeutic value of silencing both genes simultaneously in K562 and primary patient (n = 9) chronic myelogenous leukemia cells...
  14. ncbi Administration of dendritic cells transduced with antisense oligodeoxyribonucleotides targeting CD80 or CD86 prolongs allograft survival
    Xiaoyan Liang
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Transplantation 76:721-9. 2003
    ..We examined the effects of transduction with high-affinity antisense oligodeoxyribonucleotides (ODNs) designed to target the mRNA of CD80 or CD86 on the phenotype and function of dendritic cells ..
  15. pmc 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (2'F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing
    A Kalota
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nucleic Acids Res 34:451-61. 2006
    ..Therefore, our data demonstrate that PS-2'F-ANA-DNA chimeras are efficient gene silencing molecules, and suggest that they could have significant therapeutic potential...
  16. ncbi Intrahippocampal infusion of antisense oligodeoxynucleotide to the GABA(A) receptor gamma2 subunit enhances neuropeptide Y gene expression
    J D Mikkelsen
    Display Systems Biotech A/S, Copenhagen, Denmark
    Brain Res Bull 54:91-9. 2001
    ....
  17. ncbi Antisense inhibition of Flk-1 by oligonucleotides composed of 2'-deoxy-2'-fluoro-beta-D-arabino- and 2'-deoxy-nucleosides
    Julie LaCombe
    Can J Physiol Pharmacol 80:951-61. 2002
    ..Herein, we also demonstrated the capacity of the chimeric oligomers to elicit RNase H activity and their improved binding affinity for complementary RNA as compared with S-DNA...
  18. ncbi Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides
    C Thoma
    Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany
    Mol Cell 8:865-72. 2001
    ..Thus, AS treatment may result in the synthesis of N-truncated proteins with biologically relevant effects...
  19. ncbi Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cells
    L Benimetskaya
    Department of Medicine, Columbia University, New York, New York, USA
    Mol Pharmacol 60:1296-307. 2001
    ..These results underscore the complexity of the intracellular requirements for the initiation of chemosensitization to anti-neoplastic agents...
  20. ncbi Antisense candidates against protein kinase C-alpha designed based on phylogenesis and simulant structure of mRNA
    Hai feng Song
    Department of Pharmacology and Toxicology, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
    Acta Pharmacol Sin 24:269-76. 2003
    ..To optimize the antisense drug design by the combined method of phylogenetic analysis and secondary structure prediction and to get ideal candidates...
  21. ncbi Specific inhibition of estrogen receptor alpha function by antisense oligodeoxyribonucleotides
    A H Taylor
    Department of Obstetrics and Gynaecology, Faculty of Medicine and Biological Sciences, University of Leicester, Leicestershire, England
    Antisense Nucleic Acid Drug Dev 11:219-31. 2001
    We have tested the effect of a range of antisense oligodeoxyribonucleotides (ODN) directed against the human estrogen receptor alpha (ERalpha) on ERalpha protein expression and function...
  22. ncbi [Bcl-XL antisense oligodeoxynucleotide sensitizes human esophageal cancer cell line to 5-fluorouracil]
    Lei Zhang
    Henan Key Laboratory of Tumor Pathology, Department of Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
    Zhonghua Zhong Liu Za Zhi 28:173-7. 2006
    ..To investigate the effects of the Bcl-XL antisense oligodeoxynucleotides (ASODN) in suppressing the Bcl-XL expression and increasing the sensitivity of esophageal cancer cell line EC9706 to 5-fluorouracil (5-Fu)...
  23. ncbi Downregulation of bcl-2 expression in lymphoma cells by bcl-2 ARE-targeted modified, synthetic ribozyme
    Ettore Luzi
    Department of Experimental Pathology and Oncology, University of Florence, Italy
    Cancer Gene Ther 10:201-8. 2003
    ..Our results suggest a potential therapeutic application of such ribozyme for the treatment of bcl-2 overexpressing tumors...
  24. ncbi The vitamin D receptor mediates rapid changes in muscle protein tyrosine phosphorylation induced by 1,25(OH)(2)D(3)
    C Buitrago
    , , Universidad Nacional del Sur, , San Juan 670, 8000, Argentina
    Biochem Biophys Res Commun 289:1150-6. 2001
    ..Activation of tyrosine phosphorylation cascades through this mechanism may contribute to hormone regulation of muscle growth...
  25. ncbi Design and screening of antisense oligodeoxynucleotides against PAI-1 mRNA in endothelial cells in vitro
    Qi sheng Jiang
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Acta Pharmacol Sin 27:1018-23. 2006
    ..To design and screen antisense oligodeoxynucleotides (ASODNs), which inhibit type-1 plasminogen activator inhibitor (PAI-1) expression in human umbilical vein endothelial cells (HUVEC) in vitro...
  26. ncbi Negative regulation of caspase-3 expression in the neonatal cerebral cortex by alpha2A-adrenoceptors
    P N Men'shanov
    Laboratory of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk
    Bull Exp Biol Med 143:277-9. 2007
    ..The relationship between the observed effect and low expression of alpha2-adrenoceptors was confirmed by the possibility of correcting this phenomenon by clonidine (stimulator of alpha2-adrenoceptors)...
  27. ncbi Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formation
    Wen Deng
    Glycobiology Program, Center for Cancer and Transplantation Biology, Children s Research Institute and Department of Pediatrics and Biochemistry Molecular Biology, George Washington University School of Medicine, Washington, DC 20010, USA
    Glycobiology 12:145-52. 2002
    ....
  28. ncbi Bcl-XL down-regulation suppresses the tumorigenic potential of NPM/ALK in vitro and in vivo
    Addolorata Maria Luce Coluccia
    Department of Experimental Oncology, National Cancer Institute, Milan, Italy
    Blood 103:2787-94. 2004
    ..Bcl-XL deserves further investigation as a possible therapeutic target in ALK+ ALCLs...
  29. ncbi Inhibition of telomerase activity with hTERT antisense increases the effect of CDDP-induced apoptosis in myeloid leukemia
    Zhang Yuan
    Institute of Hematology, Medical College of Jinan University, Guangzhou 510632, P R China
    Hematol J 3:201-5. 2002
    ..In these studies, this phenomenon will be further investigated and expanded to leukemia cells from acute and chronic myeloid leukemia (AML and CML)...
  30. ncbi [Effect of down-regulation of survivin gene on apoptosis and cisplatin resistance in cisplatin resistant human lung adenocarcinoma A549/CDDP cells]
    Mei Chun Zhang
    Department of Respiratory Diseases, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Zhong Liu Za Zhi 28:408-12. 2006
    ..To investigate the effects of survivin antisense oligodeoxynucleoties (ASODN) transfection mediated by cytofectin on apoptosis and cisplatin resistance in cisplatin resistant human lung adenocarcinoma A549/CDDP cells in vitro...
  31. ncbi A two step model aimed at delivering antisense oligonucleotides in targeted cells
    J Toth
    CNRS UMR 1582, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Biochem Biophys Res Commun 293:18-22. 2002
    ..The subsequent addition of dendrimers allows these antisense oligonucleotides to inhibit a reporter gene inside the cells...
  32. ncbi Suppression of tumor growth using antisense oligonucleotide against survivin in an orthotopic transplant model of human hepatocellular carcinoma in nude mice
    Yuning Sun
    Beijing Institute of Radiation Medicine, Beijing 100850, PR China
    Oligonucleotides 16:365-74. 2006
    ..Taken together, these data suggest that the usefulness of survivin ASO could potentially be a promising gene therapy approach to treatment of HCC...
  33. ncbi Antisense oligonucleotides targeting midkine induced apoptosis and increased chemosensitivity in hepatocellular carcinoma cells
    Li Cheng Dai
    Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou 313000, China
    Acta Pharmacol Sin 27:1630-6. 2006
    ..This aim of this study is to screen for suitable antisense oligonucleotides (ASODN) targeting MK in hepatocellular carcinoma (HCC) cells and evaluate its antitumor activity...
  34. ncbi Antisense oligodeoxynucleotides against thrombomodulin suppress the cell growth of lung adenocarcinoma cell line A549
    Masakazu Fujiwara
    Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan
    Pathol Int 52:204-13. 2002
    ..7%, compared with 68.2% in the control transfectants. These results suggest that TM expression may play a suppressive role in the proliferation activity of A549 lung adenocarcinoma cells...
  35. ncbi Modulation of cell apoptosis by AIR
    M C Turco
    Leukemia 21:2557-9. 2007
  36. ncbi Fgf3 and Fgf8 are required together for formation of the otic placode and vesicle
    Habib Maroon
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 9RT, UK
    Development 129:2099-108. 2002
    ..We propose that Fgf3 and Fgf8 are required together for formation of the otic placode and act during the earliest stages of its induction...
  37. ncbi The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells
    Carsten B Schmidt-Weber
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 32:1196-204. 2002
    ..These results demonstrate that PTEN negatively controls costimulatory signals by antagonizing PI3 K activity in the absence of TCR engagement...
  38. ncbi Attenuation of matrix protein secretion by antisense oligodeoxynucleotides to the cyclin kinase inhibitor p21(Waf1/Cip1)
    Robert H Weiss
    Division of Nephrology, Department of Internal Medicine, TB 136 University of California, Davis, CA 95616, USA
    Atherosclerosis 161:105-12. 2002
    ....
  39. ncbi Inhibition of LNCaP prostate tumor growth in vivo by an antisense oligonucleotide directed against the human androgen receptor
    Iris E Eder
    Department of Urology, University of Innsbruck, A 6020 Innsbruck, Austria
    Cancer Gene Ther 9:117-25. 2002
    ..These results further point out the important role of the AR in prostate tumors and support further testing of AR downregulation for treatment of prostate cancer...
  40. ncbi A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis
    Atsushi Mizutani
    Department of Biotechnology, Kyoto Institute of Technology, Sakyo ku, Kyoto 606 8585, Japan
    J Biol Chem 277:15851-8. 2002
    ..These results indicate that PLAGL2 is located downstream of HIF-1 and suggest that PLAGL2 functions as a tumor suppressor in association with HIF-1...
  41. ncbi Antisense p53 transduction leads to overexpression of bcl-2 and dexamethasone resistance in multiple myeloma
    Rajaraman Iyer
    Myeloma and Transplantation Research Center, University of Arkansas for Medical Sciences and Central Arkansas VA Medical Center, Little Rock, AR 72205, USA
    Leuk Res 27:73-8. 2003
    ..In summary, our data demonstrates that loss of p53 function leads to myeloma cell progression and resistant phenotype through bcl-2-related mechanisms...
  42. ncbi [Molecular mechanism of anti-apoptotic action of survivin in NCI-H446 lung cancer cells]
    Yu Qing Chen
    Department of Respiratory Medicine, Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China
    Zhonghua Zhong Liu Za Zhi 28:413-7. 2006
    ..To investigate cell apoptosis induced by survivin ASODN and clarify the precise mechanism of anti-apoptotic action of survivin...
  43. pmc Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors
    Maurice Phil DeYoung
    Center for Molecular Biology and Biotechnology and Department of Biology, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA
    Proc Natl Acad Sci U S A 100:4760-5. 2003
    ..Our findings provide a strong rationale for the genes-to-drugs paradigm, establish SIM2-s as a molecular target for cancer therapeutics, and may further understanding of the cancer risk of Down's syndrome patients...
  44. ncbi Induction of T-type calcium channel gene expression by chronic hypoxia
    Raquel del Toro
    Laboratorio de Investigaciones Biomedicas, Departamento de Fisiología and Hospital Universitario Virgen del Rocío, Universidad de Sevilla, E 41013 Seville, Spain
    J Biol Chem 278:22316-24. 2003
    ....
  45. pmc Oncogenic potential of EAG K(+) channels
    L A Pardo
    Max Planck Institut fur experimentelle Medizin, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    EMBO J 18:5540-7. 1999
    ..Moreover, the expression of EAG favours tumour progression when transfected cells are injected into immune-depressed mice. These data provide evidence for the oncogenic potential of EAG...
  46. ncbi Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo
    Z He
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    Cancer Res 59:3222-9. 1999
    ....
  47. ncbi Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein
    Leslie N Johnson-Anuna
    Department of Pharmacology, University of Minnesota School of Medicine, Geriatric Research, Education and Clinical Center, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Neurochem 101:77-86. 2007
    ..These findings suggest that neuroprotection by simvastatin is dependent on the drug's previously unexplored and important effect of up-regulating Bcl-2...
  48. ncbi Angiogenesis and tumor proliferation/metastasis of human colorectal cancer cell line SW620 transfected with endocrine glands-derived-vascular endothelial growth factor, as a new angiogenic factor
    Takanori Goi
    Department of Surgery I, Fukui Medical University, 23 3 Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    Cancer Res 64:1906-10. 2004
    ....
  49. ncbi Up-regulation of p21 gene expression by peroxisome proliferator-activated receptor gamma in human lung carcinoma cells
    ShouWei Han
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 10:1911-9. 2004
    ..In this study, we explored the role of PPARgamma signaling on the control of gene expression of the cycle-dependent kinase inhibitor p21 in human lung carcinoma cells...
  50. ncbi 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase
    Ramandeep Rattan
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 280:39582-93. 2005
    ..Altogether, these results indicate that AICAR can be utilized as a therapeutic drug to inhibit cancer, and AMPK can be a potential target for treatment of various cancers independent of the functional tumor suppressor gene, LKB...
  51. ncbi [Suppressive effects of par-4 antisense oligodeoxynucleotide on up-regulation of intracellular calcium concentration in PC12 cell induced by glutamate and its anti-apoptosis effects]
    Chao Lu
    Department of Pediatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Zhonghua Bing Li Xue Za Zhi 34:224-8. 2005
    ..To investigate the uppressive effects of par-4 antisense oligodeoxynucleotide on the up-regulation of intracellular calcium concentration in PC12 cell induced by glutamate and its anti-apoptosis effects...
  52. ncbi Survivin antisense oligodeoxynucleotide inhibits growth of gastric cancer cells
    Jian Hui Yang
    Department of Oncological Surgery, Shidong Hospital, Ningguo Road 236, Shanghai 20090, China
    World J Gastroenterol 10:1121-4. 2004
    ..To investigate the effect of transfected survivin antisense oligonucleotide (ASODN) on proliferation and apoptosis of gastric cancer cells...
  53. ncbi [Effect of inhibiting survivin expression with antisense oligodeoxynucleotides on sensitivity of hepatocellular carcinoma cell lines HepG2 and HepG2/ADM to adriamycin]
    De Jian Dai
    Department of General Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P R China
    Ai Zheng 24:951-7. 2005
    ..This study was to investigate the effect of inhibiting survivin expression with ASODN on sensitivity of hepatocellular carcinoma cell lines HepG2 and HepG2/ADM to Adriamycin (ADM)...
  54. ncbi [Effect of phosphorothioate antisense Bcl-xL oligodeoxynucleotides on apoptosis and thermosensitivity of BcaCD885 cells]
    Yong Wen He
    Dept of Stomatology Institute, First Affiliated Hospital, Kunming Medical College, Kunming 650032, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 22:112-4. 2004
    ..To study the effect of phosphorothioate antisense Bcl-xL oligodeoxynucleotides on apoptosis and thermosensitivity of BcaCD885 cells...
  55. ncbi Antisense oligodeoxynucleotides targeting the serine/threonine kinase Pim-2 inhibited proliferation of DU-145 cells
    Jin Ming Dai
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Acta Pharmacol Sin 26:364-8. 2005
    ..To investigate the effect of antisense oligodeoxynucleotides (ASODN) targeting Pim-2 on cell proliferation of DU-145 cells...
  56. ncbi [Telomerase antisense inhibition and chemotherapeutic combination treatments for the proliferation of endometrial cancer in vitro and in vivo]
    Xue Jun Chen
    Second Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
    Zhonghua Yi Xue Za Zhi 84:1721-5. 2004
    ..To investigate the antitumor effects of telomerase antisense oligodeoxynucleotide (AODN)...
  57. pmc Survivin antisense compound inhibits proliferation and promotes apoptosis in liver cancer cells
    De Jian Dai
    Department of Surgery, Second Affiliated Hospital of Zhejiang University Medical School, Hangzhou, Zhejiang Province, China
    World J Gastroenterol 11:193-9. 2005
    ..To evaluate the effects of survivin on cell proliferation and apoptosis in liver cancer...
  58. ncbi Effects of cyclin D1 antisense oligodeoxyneucleotides on the growth and expression of G1 phase regulators in gastric carcinoma cells
    Xiaoming Shuai
    Department of General Surgery, Xiehe Hospital, Tongji Medical Collage, Huazhong University of Science and Technology University, Wuhan 430022
    J Huazhong Univ Sci Technolog Med Sci 23:396-8, 406. 2003
    ..Cyclin D1 ASODN could inhibit the growth and the expression of Cyclin D1 mRNA in gastric carcinoma cells, influence the cell cycle and expression of its regulators...
  59. ncbi [The influence of Survivin in drug resistance of breast cancer cell]
    Ping Xie
    Zhonghua Bing Li Xue Za Zhi 34:367-8. 2005
  60. ncbi Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB
    Jordi Rius
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 24:697-702. 2004
    ..Our aim was to analyze whether NOR-1 is involved in LDL-induced mitogenic effects in VSMC...
  61. ncbi An essential role of the antioxidant gene Bcl-2 in myocardial adaptation to ischemia: an insight with antisense Bcl-2 therapy
    R Hattori
    Department of Surgery, University of Connecticut School of Medicine, Farmington 06030-1110, USA
    Antioxid Redox Signal 3:403-13. 2001
    ..In concert, reduced oxidative stress in the adapted myocardium no longer persisted. The results suggest an antioxidant role of bcl-2 that appeared to be essential for the cardioprotection achieved by ischemic adaptation...
  62. pmc Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity
    A Catalano
    Department of Experimental Pathology, University of Ancona, Ancona, Italy
    Am J Pathol 159:721-31. 2001
    ..These results indicate that MetAP2 is a main regulator of proliferative and apoptotic pathways in mesothelioma cells and suggest that MetAP2 inhibition may represent a potential target for therapeutic intervention in human mesothelioma...
  63. ncbi Antisense treatment against Ki-67 mRNA inhibits proliferation and tumor growth in vitro and in vivo
    Ingo Kausch
    Department of Urology, Medical University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Int J Cancer 105:710-6. 2003
    ..001) in immunocompetent mice was significantly inhibited in antisense-treated animals. From these findings we conclude that antisense inhibition of Ki-67 protein expression may be a rational approach in anticancer therapy...
  64. ncbi Identification of metastasis-associated proteins by proteomic analysis and functional exploration of interleukin-18 in metastasis
    Daifeng Jiang
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Beijing, P R China
    Proteomics 3:724-37. 2003
    ....
  65. ncbi [Study of bcl-2 antisense oligodeoxynucleotides on reversal of cisplatin resistance in ovarian cancer cell line A2780/DDP]
    Min Li
    Department of Obstetrics and Gynecology, Union Hospital of Tongji Medical College, Huazhong Science and Technology University, Wuhan 430022, China
    Zhonghua Fu Chan Ke Za Zhi 41:121-5. 2006
    ..To evaluate the influence of bcl-2 antisense oligodeoxynucleotides (AODN) on reversing cisplatin (DDP) resistance in ovarian carcinoma cell lines...
  66. ncbi Overcoming of radioresistance in human gliomas by p21WAF1/CIP1 antisense oligonucleotide
    T Kokunai
    Department of Neurosurgery, Kakogawa Municipal Hospital, Japan
    J Neurooncol 51:111-9. 2001
    ..p21 may represent an important new target for radiosensitization protocols, possibly involving antisense oligonucleotide directed against p21...
  67. ncbi IL-2 gene and antisense TGF-beta1 strategies counteract HSV-2 transformed tumor progression
    James D Kettering
    Dept of Biochemistry and Microbiology, Loma Linda University, Loma Linda, CA 92350, USA
    Technol Cancer Res Treat 2:211-21. 2003
    ....
  68. ncbi [Inhibitory effects of transfected Bcl-XL antisense oligodeoxynucleotide on proliferation of esophageal cancer cells and growth of human esophageal carcinoma in nude mice]
    Lei Zhang
    Department of Pathology, First Affiliated Hospital, Zhengzhou University, Henan Key Laboratory of Tumor Pathology, Zhengzhou 450052, China
    Zhonghua Bing Li Xue Za Zhi 34:402-6. 2005
    ..To investigate the biologic effects of Bcl-XL antisense oligodeoxynucleotide (ASODN) transfected into cultured esophageal carcinoma cells and human esophageal carcinoma xenograft in nude mice...
  69. ncbi Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytes
    Marc Ehlers
    Hans Spemann Laboratories, Max Planck Institute of Immunology, Freiburg, Germany
    J Immunol 171:3594-604. 2003
    ..The experimental approach developed here should be valuable for the functional analysis of other candidate genes in T cell differentiation...
  70. ncbi Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins
    J Li
    Reproductive Biology Unit, Division of Gynecologic Oncology, Departments of Obstetrics and Gynecology, University of Ottawa
    Endocrinology 142:370-80. 2001
    ..These results suggest that the ability of cisplatin to down-regulate Xiap content may be an important determinant of chemosensitivity in hOSE cancer...
  71. ncbi Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma
    Eunice S Wang
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 103:258-66. 2004
    ..These data demonstrate that telomerase is important for the replication of mature B-cell neoplasia by stabilizing short telomeres, and they suggest that telomerase inhibition represents a novel therapeutic approach to MM and NHL...
  72. pmc Antisense DNAs as multisite genomic modulators identified by DNA microarray
    Y S Cho
    Cellular Biochemistry Section, Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1750, USA
    Proc Natl Acad Sci U S A 98:9819-23. 2001
    ....
  73. ncbi Hepatocyte growth factor is essential for migration of myogenic cells and promotes their proliferation during the early periods of tongue morphogenesis in mouse embryos
    Osamu Amano
    Department of Histology and Embryology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Dev Dyn 223:169-79. 2002
    ..These results suggest that HGF regulates both the migration and proliferation of myogenic cells during the earlier stages of tongue development...
  74. pmc Methylamine and benzylamine induced hypophagia in mice: modulation by semicarbazide-sensitive benzylamine oxidase inhibitors and aODN towards Kv1.1 channels
    R Pirisino
    Department of Preclinical and Clinical Pharmacology, Viale Pieraccini, 6, 50134 Florence, Italy
    Br J Pharmacol 134:880-6. 2001
    ..5 mg kg(-1) i.p.) potentiated the effect of i.p., but not of i.c.v.-administered MET. 4. Antisense oligodeoxyribonucleotides (aODN) to Kv1...
  75. ncbi Low density lipoprotein receptor-related protein is required for macrophage-mediated oxidation of low density lipoprotein by 12/15-lipoxygenase
    W Xu
    Department of Molecular Pharmacology, Kanazawa University Graduate School of Medicine, Kanazawa 920 8640, Japan
    J Biol Chem 276:36454-9. 2001
    ..Furthermore, antisense oligodeoxyribonucleotides against LRP reduced the cell-mediated LDL oxidation under the conditions in which the expression of ..
  76. ncbi Effect of K+ channel modulation on mouse feeding behaviour
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Eur J Pharmacol 329:1-8. 1997
    ..The integrity and functionality of central K+ channels appears, therefore, to be fundamental in the regulation of food intake by mice...
  77. ncbi Kir6.2 oligoantisense administered into the globus pallidus reduces apomorphine-induced turning in 6-OHDA hemiparkinsonian rats
    I Lamensdorf
    National Institute of Neurological Disorders and Stroke, Clinical Neuroscience Branch, National Institute of Health, Bethesda, MD 20892, USA
    Brain Res 818:275-84. 1999
    ....
  78. ncbi Photoactivatable antisense DNA: suppression of ampicillin resistance in normally resistant Escherichia coli
    F P Gasparro
    Department of Dermatology, Yale University, New Haven, CT 06510
    Antisense Res Dev 1:117-40. 1991
    b>Antisense oligodeoxyribonucleotides complementary to a segment of the beta-lactamase gene and containing psoralen monoadducts at specific sites were examined for their ability to make normally resistant bacteria sensitive to ampicillin...
  79. pmc Myosin IIC: a third molecular motor driving neuronal dynamics
    Steven R Wylie
    Unit of Molecular and Cellular Biology, Royal Veterinary College, University of London, London NW1 0TU, United Kingdom
    Mol Biol Cell 19:3956-68. 2008
    ..IIC function, we have applied a comparative functional knockdown approach by using isoform-specific antisense oligodeoxyribonucleotides to deplete expression within neuronally derived cells...
  80. ncbi Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox)
    Xiaoxian Zhao
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    J Biol Chem 277:25385-92. 2002
    ..occur upon activation of human monocytes and that decreased cPLA(2) protein expression, mediated by antisense oligodeoxyribonucleotides (AS-ODN) specific for cPLA(2) mRNA, blocked the stimulation-induced translocation of p47(phox) and ..
  81. ncbi Changes of conductance and compressibility of bilayer lipid membranes induced by oligonucleotide-cationic polyene antibiotic complexes
    Tibor Hianik
    Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Computer Science, Comenius University, Mlynska dolina F1, 842 48 Bratislava, Slovak Republic
    Bioelectrochemistry 74:2-8. 2008
    ..molecule amphotericin B 3-dimethylaminopropylamide (AMA) is an efficient agent for the delivery of antisense oligodeoxyribonucleotides (ODN) into target cells...
  82. pmc Targeted inhibition of gene expression of pancreatitis-associated proteins exacerbates the severity of acute pancreatitis in rats
    H Zhang
    Departments of Surgery and Pathology, State University of New York Health Science Center at Brooklyn, New York, NY 11203, USA
    Scand J Gastroenterol 39:870-81. 2004
    ..While PAP has been shown to be anti-bacterial and anti-apoptotic in vitro, its definitive biological function in vivo is not clear...
  83. ncbi Nifedipine upregulates manganese superoxide dismutase expression in vascular smooth muscle cells via endothelial cell-dependent pathways
    Keisuke Fukuo
    Department of Geriatric Medicine, Osaka University Medical School, Yamadaoka, Suita, Japan
    Hypertens Res 26:503-8. 2003
    ..Preincubation of VSMC with Mn SOD antisense oligodeoxyribonucleotides (ODN) blocked the suppressive effects of nifedipine on DNA synthesis in VSMC cocultured with EC, ..
  84. ncbi Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1
    Y Wen
    Membrane Biology Laboratory, Department of Medicine, West, Los Angeles VA Medical Center and UCLA, Los Angeles, California, 90073, USA
    Biochem Biophys Res Commun 258:713-21. 1999
    ....
  85. ncbi Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells
    Lan Liu
    Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene St, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 285:G1056-67. 2003
    ..of TGF-beta by treatment with either immunoneutralizing anti-TGF-beta antibody or TGF-beta antisense oligodeoxyribonucleotides not only blocked the induction of Smad activity but also decreased the Smad-mediated ..
  86. ncbi The large form of ADAR 1 is responsible for enhanced hepatitis delta virus RNA editing in interferon-alpha-stimulated host cells
    D Hartwig
    Institut für Immunologie und Transfusionsmedizin, Universitat zu Lubeck, Germany
    J Viral Hepat 13:150-7. 2006
    ..Thus, induction of ADAR1-L may at least partially cause the antiviral effect of IFN-alpha in natural immune response to HDV as well as in case of therapeutic administration of IFN...
  87. ncbi M1 receptor activation is a requirement for arecoline analgesia
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Farmaco 56:383-5. 2001
    ..This effect was detected 24 h after the last i.c.v. injection of aODN. These results indicate that arecoline antinociception is mediated by the activation of central M1 muscarinic receptors...
  88. ncbi Inhibition of angiogenesis in vitro by alphav integrin-directed antisense oligonucleotides
    Ralf Kronenwett
    Department of Hematology, Oncology and Clinical Immunology, University of Dusseldorf, Dusseldorf, Germany
    Cancer Gene Ther 9:587-96. 2002
    The integrin alpha v beta 3 plays a central role in angiogenesis. In this study, we used antisense oligodeoxyribonucleotides (ONs) directed against the alpha v subunit of alpha v beta 3 to inhibit integrin expression...
  89. pmc Loss of muscarinic antinociception by antisense inhibition of M(1) receptors
    C Ghelardini
    Department of Pharmacology, Viale G Pieraccini 6, University of Florence, I 50139 Florence, Italy
    Br J Pharmacol 129:1633-40. 2000
    ..These results indicate that activation of M(1) muscarinic receptor subtype is fundamental to induce central cholinergic analgesia in mice...
  90. ncbi Use of RNA interference to inhibit integrin subunit alphaV-mediated angiogenesis
    Thorsten Graef
    Department of Hematology, Oncology and Clinical Immunology, University of Duesseldorf, Germany
    Angiogenesis 8:361-72. 2005
    ..of this study was to inhibit alphaV-mediated angiogenesis in vitro using RNAs (siRNA) as well as antisense oligodeoxyribonucleotides (asON)...
  91. ncbi Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats
    Xin Qing
    Department of Comparative Biosciences, University of Wisconsin Madison, School of Veterinary Medicine, AHABS Bldg, 1656 Linden Drive, Madison, WI 53706, USA
    Am J Physiol Lung Cell Mol Physiol 285:L86-96. 2003
    ..b>Antisense oligodeoxyribonucleotides (ASODNs, 5 mg.kg-1.day-1 or 5 and 10 mg.kg-1...
  92. ncbi CD40 ligation stimulates MCP-1 and IL-8 production, TRAF6 recruitment, and MAPK activation in proximal tubule cells
    Hongye Li
    Division of Nephrology, Department of Medicine, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Am J Physiol Renal Physiol 282:F1020-33. 2002
    ..TRAF6, in turn, activates SAPK/JNK and p38 MAPK phosphorylation, which in turn stimulates IL-8 and MCP-1 production in these cells...
  93. ncbi Antisense modulation of the coding or regulatory sequence of the folate receptor (folate binding protein-1) in mouse embryos leads to neural tube defects
    Deborah K Hansen
    Division of Genetic and Reproductive Toxicology, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079 9502, USA
    Birth Defects Res A Clin Mol Teratol 67:475-87. 2003
    ..We have employed antisense technology to alter expression of the gene for the folate receptor (folate binding protein-1 [Folbp1]) in mouse embryos cultured in vitro...
  94. ncbi Role of protein kinase C isoforms in the regulation of interleukin-13-induced 15-lipoxygenase gene expression in human monocytes
    Bo Xu
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 279:15954-60. 2004
    ..Down-regulation of cellular PKCdelta protein levels by PKCdelta-specific antisense oligodeoxyribonucleotides also inhibited 15-LO expression markedly...
  95. ncbi Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L
    S C Shih
    Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 274:1359-65. 1999
    ..Thus, we propose that specific association of hnRNP L with VEGF mRNA under hypoxia may play an important role in hypoxia-induced post-transcriptional regulation of VEGF mRNA expression...
  96. ncbi Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain
    Mir Ahamed Hossain
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:4187-96. 2004
    ..Transfecting cortical neurons with antisense oligodeoxyribonucleotides directed against NP1 mRNA (NP1AS) significantly inhibited (p < 0...
  97. ncbi Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase D
    Elisabetta Meacci
    Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, Florence, Italy
    Biochim Biophys Acta 1633:133-42. 2003
    ..was also supported by the marked reduction of S1P-induced PLD activity in myoblasts loaded with antisense oligodeoxyribonucleotides (ODN) to EDG5/S1P2...
  98. ncbi Nifedipine indirectly upregulates superoxide dismutase expression in endothelial cells via vascular smooth muscle cell-dependent pathways
    Keisuke Fukuo
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Osaka, Japan
    Circulation 106:356-61. 2002
    ..We hypothesized that vascular smooth muscle cells (VSMCs) are involved in the mechanism underlying the normalization of endothelial dysfunction by calcium antagonists...
  99. ncbi The principles of MiRNA-masking antisense oligonucleotides technology
    Zhiguo Wang
    Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, QC, Canada
    Methods Mol Biol 676:43-9. 2011
    ..J Cell Physiol 212:285-292; Wang et al., J Mol Med 86:772-783, 2008) and a similar approach with the same concept was subsequently reported by Schier's laboratory (Choi et al., Science 318:271-274, 2007)...
  100. ncbi Different role of antioxidants in endotoxin-induced late myocardial protection
    S Wang
    Gan Quan Hospital, Shanghai Tiedao University, Shanghai, People s Republic of China
    J Surg Res 82:188-93. 1999
    ..It seems that different doses of endotoxin pretreatment may induce delayed myocardial protection through various mechanisms...
  101. ncbi Antisense oligonucleotides complementary to immunoglobulin sequences of BCL-2/immunoglobulin fusion transcript induce apoptosis of t(14;18) lymphoma cells
    M R Smith
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Br J Haematol 111:1087-92. 2000
    b>Antisense oligodeoxyribonucleotides directed at the bcl-2 translational start site downregulate bcl-2 and inhibit growth of the t(14;18)-positive lymphoma line WSU-FSCCL...

Research Grants63

  1. Targeted Lipopolyplexes for Oligonucleotide Delivery to AML
    Robert J Lee; Fiscal Year: 2012
    ..seek to develop novel nanotechnology to create multifunctional immunonanoparticles for the delivery antisense oligodeoxyribonucleotides to treat acute myeloid leukemia (AML)...
  2. SOMATOSTATIN RECEPTORS--CLASSIFICATION OF NEUROBLASTOMAS
    M O DORISIO; Fiscal Year: 1999
    ..Down-regulation of SSR1, SSR2, and SSR3 will be attempted using antisense oligodeoxyribonucleotides. Functional experiments will examine the effect of somatostatin and stable analogs of somatostatin ..
  3. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2006
    ..Using both pharmacological and molecular approaches (e.g. antisense oligodeoxyribonucleotides to MnSOD), we will independently prevent the exercise-induced synthesis of myocardial MnSOD and GSH...
  4. INTERLEUKIN 13 STIMULATION OF HUMAN MONOCYTES
    MARTHA CATHCART; Fiscal Year: 2002
    ..These studies will substantially enhance our understanding of the signaling mechanisms induced upon exposure of monocytes to IL-13 and may suggest specific and selective means for modulating this response. ..
  5. ONTOGENY AND EXPRESSION OF THE CFTR IN BRAIN
    ANDREW MULBERG; Fiscal Year: 2003
    ..b>Antisense oligodeoxyribonucleotides developed against the CFTR gene and inhibitors of CFTR C1 conductance will be screened for effects ..
  6. COMPARATIVE ANALYSIS OF CLOCK GENES
    STEVEN REPPERT; Fiscal Year: 2001
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  7. Examing Oligonucleotide Effects on Gene Expression
    Alan Gewirtz; Fiscal Year: 2007
    ..It is our belief that such molecules will have an important impact on the diagnosis, and treatment of neoplastic diseases. ..
  8. Developing Nucleic Acid Therapeutics
    Alan Gewirtz; Fiscal Year: 2007
    ..abstract_text> ..
  9. A Metabolomic Approach to Discovering Biomarkers for ADPKD
    Robert H Weiss; Fiscal Year: 2010
    ..In addition, work from this proposal will lead to new knowledge about the pathology of the disease and to selection of patients who will most benefit from any new drug. ..
  10. Reactive astrocytes from gliotic capsule
    J Marc Simard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  11. EGF, Oxidants & Intestinal Barrier Integrity
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  12. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2004
    ....
  13. REGULATION OF INTESTINAL EPITHELIAL CHEMOKINE SECRETION
    Andrew Gewirtz; Fiscal Year: 2002
    ..In addition to containing an extensive array of basic research equipment, this lab space contains a new thermostatted spectrofluorimeter to be used primarily by Dr. Gewirtz. ..
  14. Protective Mechanism of an Anti-Inflammatory Herbal Mix
    Ali Banan; Fiscal Year: 2006
    ..abstract_text> ..
  15. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Marc Simard; Fiscal Year: 2007
    ..abstract_text> ..
  16. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..
  17. Excellence in Cardiovascular Sciences Summer Research
    Debra Diz; Fiscal Year: 2007
    ..Moreover, all students regarded the experience as a positive influence on their career and 76% of those who responded said they plan to pursue some aspect of biomedical research as a career. ..
  18. Thrombomodulin Links Coagulation to Inflammation
    Edward Conway; Fiscal Year: 2006
    ..The results of the studies, to be tested in an excellent environment, will hopefully provide new insights that will lead to the design of more effective therapeutic approaches for inflammatory disease. ..
  19. Epithelial Na channel (ENaC) polymorphisms in hyptertention
    James Stockand; Fiscal Year: 2007
    ..Preliminary results support the feasibility of this investigation and suggest that this line of inquiry will yield significant and novel findings. [unreadable] [unreadable]..
  20. NEURONAL DEGENERATION: MECHANISMS AND PREVENTION
    CAROL TROY; Fiscal Year: 2007
    ..4. To determine how caspases-8 and -7 are activated after SOD1 down-regulation. 5. To determine if there is activation/regulation of caspase-3 and other caspases after SOD1 down-regulation. ..
  21. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
  22. RVM CCK and Neuropathic Pain
    Josephine Lai; Fiscal Year: 2007
    ..In this regard, the proposed experiments may reveal an important role for CCK receptor antagonists as therapy for neuropathic pain. ..
  23. Stoichiometry and modular retrieval of ENaC
    James Stockand; Fiscal Year: 2009
    ..This research will provide critical insight about the molecualr architecture of ENaC and regulation of this important channel. ..
  24. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..
  25. Modulation of radiosensitivity in zebrafish
    William Davidson; Fiscal Year: 2008
    ..This work will be performed by using state-of-the-art methods of downregulating gene expression or function and has important translational ramifications. ..
  26. Combination Strategies for Angiogenesis Inhibition
    Keith Flaherty; Fiscal Year: 2008
    ..He is a recognized leader in the field of investigational therapies, has a record of mentoring successful clinical researchers, and is committed to Dr. Flaherty's training. ..
  27. Prescription opioid agonists: tolerance and efficacy
    BYRON YOBURN; Fiscal Year: 2008
    ..Overall, the results of this project will provide new and important information on the pharmacodynamics and mechanism of action of a group of opioid analgesics that are potential drugs of abuse. [unreadable] [unreadable] [unreadable]..
  28. GLOMERULAR CAPILLARY WALL--NORMAL AND PATHOLOGIC
    Yashpal Kanwar; Fiscal Year: 2008
    ..Null alleles will be interbred to generate Null -/- mutant as a conventional KO mice with ablation of the TIN-ag gene. ..
  29. Downstream Regulators of Beta-Amyloid Induced Neuronal Death
    Carol M Troy; Fiscal Year: 2010
    ..2: To determine how caspase-2 is regulated and activated by A_ and TFD. 3: To determine how caspase-2 induces of Bim expression. ..
  30. Neurophysiology and Biomechanics of Urethra in Stress Urinary Incontinence
    Naoki Yoshimura; Fiscal Year: 2008
    ..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
  31. Control of Vascular Smooth Muscle Function by Insulin
    Louis Ragolia; Fiscal Year: 2006
    ..abstract_text> ..
  32. Mechanism of Action of G3139
    CY STEIN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. Nucleic Acid Triggered Prodrug and Probe Activation
    John Stephen Taylor; Fiscal Year: 2003
    ....
  34. Protein Kinase in Opioid Receptor Regulation & Tolerance
    BYRON YOBURN; Fiscal Year: 2003
    ..As such, these results may provide important insights for developing strategies to treat opioid drug abuse and pain. ..
  35. OSTEOCLASTIC PHOSPHOTYROSYL PHOSPHATASE AND RESORPTION
    KIN HING LAU; Fiscal Year: 2002
    ....
  36. ROLE OF VEGF AND NRP 1 IN ESTROGEN INDUCED ANGIOGENESIS
    Sushanta Banerjee; Fiscal Year: 2002
    ..Specific aim 4will address the question whether negative regulators like thrombospondin-1 that influence the action of VEGF164 during the development of estrogen induced tumor angiogenesis control the expression of NRP-1. ..
  37. NOVEL ANIMAL MODELS OF HCV-RELATED HEPATOCARCINOGENESIS
    Raymond Chung; Fiscal Year: 2003
    ..Together, these models will help provide insights into the factors responsible for this devastating complication of chronic HCV infection. ..
  38. PREVENTIVE ONCOLOGY ACADEMIC CAREER DEVELOPMENT AWARD
    Patrick Koty; Fiscal Year: 2002
    ..The data obtained from these studies will also be used to develop a model for the process of programmed cell death. This model will be used to determine risk assessment for the development of non-small cell lung cancer. ..
  39. PHARMACOLOGY OF CYCLOSPORINE BASED IMMUNOSUPPRESSION
    Barry Kahan; Fiscal Year: 2004
    ....
  40. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  41. Lactococcal vaccine for strep throat
    Bruce Geller; Fiscal Year: 2004
    ..pyogenes ..
  42. Pathobiology of HMG-CoA reductase inhibitors in diabetes
    Yashpal Kanwar; Fiscal Year: 2006
    ....
  43. SELECTIVE BLOCKADE OF TTX-R SODIUM CHANNELS FOR PAIN
    Josephine Lai; Fiscal Year: 2001
    ..These studies may have great practical significance towards the development of an effective therapy for neuropathic pain with few, or no, side effects. ..
  44. MOLECULAR STUDIES OF GENE TARGETED OLIGONUCLEOTIDES
    CY STEIN; Fiscal Year: 2002
    ..Finally, in Specific Aim 3, we will amplify the delivery of alt-OMPs and chi-OMPs to cells by condensing them with a novel delivery agent, tetra (N-methylpyridyl) porphine. ..
  45. Chemical Genetics:Cellular Regulators of HCV (RMI)
    Raymond Chung; Fiscal Year: 2004
    ..Second, discovery of hit compounds that positively or negatively regulate HCV replication will ultimately help lead to identification of novel cellular targets that can be exploited to further interrupt the viral lifecycle. ..
  46. Orthogonal Strategies for Specific Knockout Production
    CY STEIN; Fiscal Year: 2005
    ..Finally, in Specific Aim 4, we will evaluate the molecular consequences of the down regulation of bcl-2 and bcl-xL by employing the 12,000 gene-containing Affymetrix oligonucleotide microarray technology. ..
  47. NURR1 EXPRESSION AND DAERGIC DYSFUNCTION RELEVANT TO PD
    Wei Dong LE; Fiscal Year: 2003
    ....
  48. Downstream Regulators of Beta-Amyloid Induced Neuronal Death
    CAROL TROY; Fiscal Year: 2008
    ..2: To determine how caspases are regulated and activated by A[unreadable] and TFD. 3: To determine how caspase-2 regulates the induction of Bim after A[unreadable] treatment. ..
  49. HIV-Hepatitis C Virus Interactions and Pathogenesis
    Raymond T Chung; Fiscal Year: 2010
    ..These studies will shed considerable light on HIV-HCV pathogenic interactions and offer a means of productively disrupting these interactions. ..
  50. COCAINE INDUCED BEHAVIORAL SENSITIZATION AND SEIZURES
    Marc Abel; Fiscal Year: 2001
    ..It is anticipated that these studies will provide important new information regarding mechanisms of sensitization and seizure initiation in cocaine abuse, which may suggest new approaches in intervention in cocaine toxicity. ..
  51. Mechanisms of p42/44MAPK-induced LDL receptor expression
    KAMAL MEHTA; Fiscal Year: 2004
    ..This knowledge could be exploited to develop improved hypercholesterolemia therapies and to reduce foam cell formation. ..
  52. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  53. Cellular and Molecular Mechanisms Regulating Photoreceptor Morphology
    ABIGAIL JENSEN; Fiscal Year: 2008
    ..This raises the interesting question as to whether this phenomenon is causal or whether compromised or sick photoreceptors are unable to maintain their inner and outer segments. ..
  54. NURR1 Gene Mutations in Parkinson's Disease
    Weidong Le; Fiscal Year: 2006
    ....
  55. Tat-Driven Delivery of 2-5A Cargo for HIV RNA Ablation
    PAUL TORRENCE; Fiscal Year: 2003
    ..This Tat lector-driven transport of 2-5A cargo would provide a major advantage over standard antisense nucleiccid strategies that suffer from inefficient cellular uptake, ..
  56. Multianalyte Assays for Cardiovascular Disease
    Debra Diz; Fiscal Year: 2005
    ..As such the peptide and protein applications developed in this proposal will be ideal for widespread use. ..
  57. CEA BASED VACCINE THERAPY IN PATIENTS WITH ADVANCED CA
    John Marshall; Fiscal Year: 2005
    ..So far, the applicant's experience with the first generation CEA-based vaccines has generated a great deal of excitement, and yet he anticipates even more from the newer vaccine constructs. ..
  58. Leukocyte-Endothelium Interactions in Aging
    Rosario Scalia; Fiscal Year: 2002
    ..The overall goal is to identify biological markers of aging and to help developing intervention strategies to delay or prevent senescence of the cardiovascular and immune systems. ..
  59. Role of the 4A11 antigen in rheumatoid arthritis
    Mohammad Amin; Fiscal Year: 2008
    ..Targeting this antigen may provide a potential therapeutic to RA. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  60. Targeted Liposomal Doxorubicin Delivery to Leukemia
    Robert Lee; Fiscal Year: 2007
    ..abstract_text> ..
  61. SEX STEROID REGULATION OF IGF-I EXPRESSION IN BONE
    Thomas McCarthy; Fiscal Year: 2003
    ..Bone mass studies will be conducted using peripheral quantitative computer tomography, and will be correlated with basal and activated skeletal IGF-I expression. ..
  62. Role of Estrogen in Stimulated Water Intake
    Eric Krause; Fiscal Year: 2005
    ..By doing so, we will test the overall hypothesis that central interactions between estrogen and angiotensin II underlie the effect of estrogen on physiologically stimulated water intake. ..