homoserine

Summary

Top Publications

  1. pmc Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment
    Victoria E Wagner
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Bacteriol 185:2080-95. 2003
  2. pmc N-acyl homoserine lactone production by Klebsiella pneumoniae isolated from human tongue surface
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:3472-83. 2012
  3. ncbi Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase
    Y H Dong
    Institute of Molecular Agrobiology, National University of Singapore, Singapore
    Nature 411:813-7. 2001
  4. ncbi The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule
    S Schauder
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Microbiol 41:463-76. 2001
  5. ncbi The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones
    Eric Déziel
    Department of Surgery, Harvard Medical School, Massachusetts General Hospital, 50 Blossom Street, MA, USA
    Mol Microbiol 55:998-1014. 2005
  6. pmc Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes
    J P Pearson
    Department of Microbiology, University of Iowa, Iowa City 52242
    Proc Natl Acad Sci U S A 91:197-201. 1994
  7. pmc Look who's talking: communication and quorum sensing in the bacterial world
    Paul Williams
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Philos Trans R Soc Lond B Biol Sci 362:1119-34. 2007
  8. pmc Communication among oral bacteria
    Paul E Kolenbrander
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
    Microbiol Mol Biol Rev 66:486-505, table of contents. 2002
  9. pmc Bacteria-host communication: the language of hormones
    Vanessa Sperandio
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Proc Natl Acad Sci U S A 100:8951-6. 2003
  10. pmc Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing
    Matthew B Neiditch
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 126:1095-108. 2006

Detail Information

Publications248 found, 100 shown here

  1. pmc Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment
    Victoria E Wagner
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Bacteriol 185:2080-95. 2003
    ..mutant (PAO-JP2) that was cultured with and without added exogenous autoinducers [N-(3-oxododecanoyl) homoserine lactone and N-butyryl homoserine lactone]...
  2. pmc N-acyl homoserine lactone production by Klebsiella pneumoniae isolated from human tongue surface
    Wai Fong Yin
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Sensors (Basel) 12:3472-83. 2012
    ..by producing quorum sensing molecules called autoinducers, which include autoinducer-1, an N-hexanoyl homoserine lactone (AHL), and autoinducer-2...
  3. ncbi Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase
    Y H Dong
    Institute of Molecular Agrobiology, National University of Singapore, Singapore
    Nature 411:813-7. 2001
    ..Quorum-sensing signals, such as acyl-homoserine lactones (AHLs), are the essential components of the communication system...
  4. ncbi The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule
    S Schauder
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Microbiol 41:463-76. 2001
    ..In Gram-negative bacteria, quorum sensing typically involves the production, release and detection of acylated homoserine lactone signalling molecules called autoinducers...
  5. ncbi The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones
    Eric Déziel
    Department of Surgery, Harvard Medical School, Massachusetts General Hospital, 50 Blossom Street, MA, USA
    Mol Microbiol 55:998-1014. 2005
    ..aeruginosa QS-controlled genes without altering the expression of lasRI/rhlRI or the production of N-acyl-L-homoserine lactone (AHL) signals. Dissection of how mvfR is interwoven into the P...
  6. pmc Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes
    J P Pearson
    Department of Microbiology, University of Iowa, Iowa City 52242
    Proc Natl Acad Sci U S A 91:197-201. 1994
    ..The elucidation of the PAI structure suggests therapeutic approaches toward control of P. aeruginosa infections...
  7. pmc Look who's talking: communication and quorum sensing in the bacterial world
    Paul Williams
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Philos Trans R Soc Lond B Biol Sci 362:1119-34. 2007
    ..Quorum sensing also crosses the prokaryotic-eukaryotic boundary since quorum sensing-dependent signalling can be exploited or inactivated by both plants and mammals...
  8. pmc Communication among oral bacteria
    Paul E Kolenbrander
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
    Microbiol Mol Biol Rev 66:486-505, table of contents. 2002
    ..A successful search for genes critical for mixed-species community organization will be accomplished only when it is conducted with mixed-species communities...
  9. pmc Bacteria-host communication: the language of hormones
    Vanessa Sperandio
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Proc Natl Acad Sci U S A 100:8951-6. 2003
    ..Given that eukaryotic cell-to-cell signaling typically occurs through hormones, and that bacterial cell-to-cell signaling occurs through QS, we speculate that QS might be a "language" by which bacteria and host cells communicate...
  10. pmc Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing
    Matthew B Neiditch
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 126:1095-108. 2006
    ..We propose that formation of this asymmetric quaternary structure is responsible for repressing the kinase activity of both LuxQ subunits and triggering the transition of V. harveyi into quorum-sensing mode...
  11. ncbi N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms
    K Riedel
    Department of Microbiology, TUM, Am Hochanger 4, D-85350 Freising, Germany
    Microbiology 147:3249-62. 2001
    ....
  12. pmc Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism
    Nikhat Parveen
    Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 225 Warren Street, Newark, NJ 07103 3535, USA
    Mol Microbiol 79:7-20. 2011
    ..Therefore, new inhibitors are currently being explored for development of potential novel broad-spectrum antimicrobials...
  13. ncbi Bacterial cell-to-cell communication: sorry, can't talk now - gone to lunch!
    Klaus Winzer
    Institute of Infections and Immunity, University of Nottingham, Queen s Medical Centre, NG7 2UH, Nottingham, United Kingdom
    Curr Opin Microbiol 5:216-22. 2002
    ..This depends on rigorous chemical characterisation and demonstration that the molecule controls cellular responses beyond those required to metabolise or detoxify the signal...
  14. pmc Production of acylated homoserine lactones by psychrotrophic members of the Enterobacteriaceae isolated from foods
    L Gram
    Danish Institute for Fisheries Research, Department of Seafood Research, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Appl Environ Microbiol 65:3458-63. 1999
    Bacteria are able to communicate and gene regulation can be mediated through the production of acylated homoserine lactone (AHL) signal molecules. These signals play important roles in several pathogenic and symbiotic bacteria...
  15. pmc RND type efflux pump system MexAB-OprM of Pseudomonas aeruginosa selects bacterial languages, 3-oxo-acyl-homoserine lactones, for cell-to-cell communication
    Shu Minagawa
    Department of Microbiology and Infection Control Science, Kyoto Pharmaceutical University, Yamashina, Kyoto 607 8414, Japan
    BMC Microbiol 12:70. 2012
    ..Gram-negative bacteria use a variety of self-produced autoinducers such as acylated homoserine lactones (acyl-HSLs) as signal compounds for quorum sensing (QS) within and between bacterial species...
  16. ncbi Characterization of the Erwinia chrysanthemi expI-expR locus directing the synthesis of two N-acyl-homoserine lactone signal molecules
    W Nasser
    Laboratoire de Génétique Moléculaire des Microorganismes et des Interactions Cellulaires, UMR CNRS 5577, INSA, Villeurbanne, France
    Mol Microbiol 29:1391-405. 1998
    The plant pathogen Erwinia chrysanthemi produces three acyl-homoserine lactones (acyl-HSLs)...
  17. ncbi Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-L-homoserine lactone and attenuates oxidative stress induced by pyocyanin
    Sven Horke
    Department of Pharmacology, University Medicine Mainz, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany
    Biochem J 426:73-83. 2010
    Two virulence factors produced by Pseudomonas aeruginosa are pyocyanin and N-(3-oxododecanoyl)-L-homoserine lactone (3OC12). Pyocyanin damages host cells by generating ROS (reactive oxygen species)...
  18. pmc Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production
    M G Surette
    Department of Microbiology and Infectious Diseases, University of Calgary, 3330 Hospital Drive, North West, Calgary, Alberta, T2N 4N1, Canada
    Proc Natl Acad Sci U S A 96:1639-44. 1999
    ..coli DH5alpha luxSE.c. gene shows that it contains a frameshift mutation resulting in premature truncation of the LuxSE.c. protein. Our results indicate that the luxS genes define a new family of autoinducer-production genes...
  19. pmc Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli
    Karina B Xavier
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    J Bacteriol 187:238-48. 2005
    ..These findings show that, depending on the prevailing growth conditions, the amount of time that the AI-2 signal is present and, in turn, the time that a given community of bacteria remains exposed to this signal can vary greatly...
  20. ncbi Structural identification of a bacterial quorum-sensing signal containing boron
    Xin Chen
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Nature 415:545-9. 2002
    ..Furthermore, they indicate a potential biological role for boron, an element required by a number of organisms but for unknown reasons...
  21. ncbi Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones
    Yong Yao
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 355:262-73. 2006
    ..domain of the quorum sensing protein SdiA of Escherichia coli and a candidate autoinducer N-octanoyl-L-homoserine lactone (C8-HSL) has been calculated in solution from NMR data...
  22. pmc Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis
    T T Hoang
    Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Bacteriol 181:5489-97. 1999
    ..When coupled to FabI, purified P. aeruginosa N-butyryl-L-homoserine lactone (C4-HSL) synthase, RhlI, could synthesize C4-HSL from crotonyl-ACP and S-adenosylmethionine...
  23. ncbi Quorum sensing in vibrios: complexity for diversification
    Debra L Milton
    Department of Molecular Biology, Umea University, SE 90187 Umea, Sweden
    Int J Med Microbiol 296:61-71. 2006
    ..Further studies are likely to show that the diversity and complexity of the Vibrio quorum-sensing systems coordinate intraspecies behaviour, niche occupation, and possibly evolution...
  24. pmc Bacterial small-molecule signaling pathways
    Andrew Camilli
    Howard Hughes Medical Institute, 136 Harrison Avenue, Boston, MA 02111 1817, USA
    Science 311:1113-6. 2006
    ..We suggest how these two pathways may converge to control complex processes including multicellularity, biofilm formation, and virulence. We also outline new questions that have arisen from recent studies in these fields...
  25. ncbi Engineered biological nanofactories trigger quorum sensing response in targeted bacteria
    Rohan Fernandes
    Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, USA
    Nat Nanotechnol 5:213-7. 2010
    ..We envision the use of these nanofactories in generating new antimicrobial treatments that target the communication networks of bacteria rather than their viability...
  26. pmc Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp
    Gilles Brackman
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium
    PLoS ONE 6:e16084. 2011
    ..However, little is known about the structure-activity relationship of cinnamaldehyde analogs...
  27. pmc Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)
    Andres F Gonzalez Barrios
    Dept of Chemical Engineering, University of Connecticut, 191 Auditorium Road, Storrs, CT 06269 3222, USA
    J Bacteriol 188:305-16. 2006
    ..Together, these results indicate AI-2 induces biofilm formation in E. coli through B3022, which then regulates QseBC and motility; hence, b3022 has been renamed the motility quorum-sensing regulator gene (the mqsR gene)...
  28. pmc Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase
    Jiwoung Chung
    Department of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Korea
    Proc Natl Acad Sci U S A 108:12089-94. 2011
    ..In gram-negative bacteria, QS is often mediated by N-acyl-L-homoserine lactones (acyl-HSLs)...
  29. pmc Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia
    Christian Schwarzer
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Cell Microbiol 14:698-709. 2012
    ..cystic fibrosis (CF) patients, a process regulated by quorum-sensing molecules including N-(3-oxododecanoyl)-l-homoserine lactone (C12)...
  30. pmc Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi
    Jennifer M Henke
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    J Bacteriol 186:6902-14. 2004
    ..Together these communication systems act as a three-way coincidence detector in the regulation of a variety of genes, including those responsible for bioluminescence, type III secretion, and metalloprotease production...
  31. ncbi Significant immunomodulatory effects of Pseudomonas aeruginosa quorum-sensing signal molecules: possible link in human sepsis
    Pisake Boontham
    Division of Surgery, University of Nottingham, Nottingham NG7 2UH, U K
    Clin Sci (Lond) 115:343-51. 2008
    ....
  32. ncbi LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing
    Ting Xue
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
    Cell Res 19:1258-68. 2009
    ..Furthermore, in agreement with the conclusion that phosphorylated AI-2 can relieve the repression of LsrR in previous studies, our data show that phospho-AI-2 renders LsrR unable to bind to its own promoter in vitro...
  33. ncbi IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2
    R S Smith
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 167:366-74. 2001
    ..The Pseudomonas autoinducer, N-3-oxododecanoyl homoserine lactone (3-O-C12-HSL), is a small lipid-soluble molecule that is essential in the regulation of many P...
  34. ncbi Bacillus megaterium CYP102A1 oxidation of acyl homoserine lactones and acyl homoserines
    Puneet K Chowdhary
    Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75080, USA
    Biochemistry 46:14429-37. 2007
    ..Acyl homoserine lactones (AHLs) are a major class of quorum sensing signaling molecules...
  35. pmc Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein
    Manjunath Hegde
    3122 TAMU, Texas A and M University, College Station, TX 77843 3122, USA
    J Bacteriol 193:768-73. 2011
    ..We show that AI-2 strongly attracts Escherichia coli. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm...
  36. ncbi Novel quorum-sensing-controlled genes in Erwinia carotovora subsp. carotovora: identification of a fungal elicitor homologue in a soft-rotting bacterium
    C L Pemberton
    Mol Plant Microbe Interact 18:343-53. 2005
    Seven new genes controlled by the quorum-sensing signal molecule N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) have been identified in Erwinia carotovora subsp. carotovora...
  37. pmc DNA microarray-based identification of genes controlled by autoinducer 2-stimulated quorum sensing in Escherichia coli
    M P Delisa
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, University of Maryland, College Park, Maryland 20742, USA
    J Bacteriol 183:5239-47. 2001
    ..Significant induction of ygeV, a putative sigma(54)-dependent transcriptional activator, and yhbH, a sigma(54) modulating protein, suggests sigma(54) may be involved in E. coli quorum sensing...
  38. pmc Sinorhizobium meliloti, a bacterium lacking the autoinducer-2 (AI-2) synthase, responds to AI-2 supplied by other bacteria
    Catarina S Pereira
    Bacterial Signaling Laboratory, Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Mol Microbiol 70:1223-35. 2008
    ..Our findings suggest that S. meliloti is capable of 'eavesdropping' on the AI-2 signalling of other species and interfering with AI-2-regulated behaviours such as virulence...
  39. ncbi Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria
    Karina B Xavier
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    ACS Chem Biol 2:128-36. 2007
    ..This series of chemical events is proposed to enable enteric bacteria to respond to the presence of competitor bacteria by sequestering and destroying AI-2, thereby eliminating the competitors' intercellular communication capabilities...
  40. pmc Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture
    Jun Li
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    J Bacteriol 189:6011-20. 2007
    ..Our results suggest that AI-2 is indeed a QS signal in E. coli, especially when it acts through the transcriptional regulator LsrR...
  41. pmc Peroxisome proliferator-activated receptors mediate host cell proinflammatory responses to Pseudomonas aeruginosa autoinducer
    Aruna Jahoor
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX 79430, USA
    J Bacteriol 190:4408-15. 2008
    The pathogenic bacterium Pseudomonas aeruginosa utilizes the 3-oxododecanoyl homoserine lactone (3OC(12)-HSL) autoinducer as a signaling molecule to coordinate the expression of virulence genes through quorum sensing...
  42. pmc LuxS-based signaling in Streptococcus gordonii: autoinducer 2 controls carbohydrate metabolism and biofilm formation with Porphyromonas gingivalis
    Roderick McNab
    Department of Microbiology, Eastman Dental Institute, University College, London WC1 8LD, United Kingdom
    J Bacteriol 185:274-84. 2003
    ..Furthermore, LuxS-dependent intercellular communication is essential for biofilm formation between nongrowing cells of P. gingivalis and S. gordonii...
  43. pmc Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen
    Nazanin Saeidi
    School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore
    Mol Syst Biol 7:521. 2011
    ..These results suggest that E. coli carrying our synthetic genetic system may provide a novel synthetic biology-driven antimicrobial strategy that could potentially be applied to fighting P. aeruginosa and other infectious pathogens...
  44. pmc The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo
    Roger S Smith
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bacteriol 184:1132-9. 2002
    ..These systems are composed of LuxR-type proteins, LasR and RhlR, and two acyl homoserine lactone (AHL) synthases, LasI and RhlI...
  45. ncbi Type II quorum sensing regulates virulence in Erwinia carotovora ssp. carotovora
    Eve Laasik
    Department of Genetics, Institute of Molecular and Cell Biology, Tartu University, Estonian Biocenter, Tartu, Estonia
    FEMS Microbiol Lett 258:227-34. 2006
    ..The findings reported here demonstrate that the LuxS-dependent signaling affects the progression of disease symptoms during the early stages of infection by modulating the expression of pectinolytic enzymes...
  46. ncbi LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence
    Nicola A Burgess
    Institute of Infections and Immunity, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Microbiology 148:763-72. 2002
    ..However, these reductions in virulence determinant levels were insufficient to attenuate the luxS mutant in a murine lesion model of P. gingivalis infection...
  47. pmc Probing autoinducer-2 based quorum sensing: the biological consequences of molecules unable to traverse equilibrium states
    Kyoji Tsuchikama
    The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Org Chem 76:6981-9. 2011
    ....
  48. pmc The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils
    Kazuhiro Tateda
    Department of Microbiology, Toho University School of Medicine, 5 21 16 Ohmorinishi, Ohtaku, Tokyo 143 8540, Japan
    Infect Immun 71:5785-93. 2003
    ..major quorum-sensing components, and they are regulated by their corresponding autoinducers, N-3-oxododecanoyl homoserine lactone (3-oxo-C(12)-HSL) and N-butyryl-L-homoserine lactone (C(4)-HSL)...
  49. pmc Quantifying the integration of quorum-sensing signals with single-cell resolution
    Tao Long
    Department of Physics, Princeton University, Princeton, NJ, USA
    PLoS Biol 7:e68. 2009
    ..We speculate that the use of multiple autoinducers allows a growing population of cells to synchronize gene expression during a series of distinct developmental stages...
  50. ncbi N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing
    Sandra Castang
    Unité de Microbiologie et Génétique, UMR CNRS INSA UCB 5122, Bât A Lwoff, UCB, 69622 Villeurbanne, France
    Bioorg Med Chem Lett 14:5145-9. 2004
    ..These compounds were evaluated for their ability to competitively inhibit the action of 3-oxohexanoyl-L-homoserine lactone, the natural ligand of the quorum sensing transcriptional regulator LuxR, which in turn activates ..
  51. ncbi Synthesis and biological evaluation of new N-acyl-homoserine-lactone analogues, based on triazole and tetrazole scaffolds, acting as LuxR-dependent quorum sensing modulators
    Mohamad Sabbah
    INSA Lyon, ICBMS, Bât J Verne, 20 av A Einstein, 69621 Villeurbanne Cedex, France
    Bioorg Med Chem 20:4727-36. 2012
    New analogues of N-acyl-homoserine-lactone (AHL), in which the amide was replaced by a triazole or tetrazole ring, were prepared and tested for their activity as LuxR-dependent QS modulators...
  52. ncbi Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs
    Hadas Ganin
    Department of Chemistry, Ben Gurion University of the Negev, Be er Sheva 84105, Israel
    Bioorg Med Chem Lett 19:3941-4. 2009
    ..Unexpectedly, several of the analogs were found to function as synergistic QS agonists in V. harveyi, while two of these analogs inhibit QS in P. aeruginosa...
  53. ncbi Exogenous Yersinia pestis quorum sensing molecules N-octanoyl-homoserine lactone and N-(3-oxooctanoyl)-homoserine lactone regulate the LcrV virulence factor
    H Carl Gelhaus
    United States Army Medical Institute of Infectious Diseases, Bacteriology Division, 1425 Porter St, 21702 Ft Detrick, MD, USA
    Microb Pathog 46:283-7. 2009
    ..Researchers have shown that N-acyl-homoserine lactones (AHLs) can down-regulate the expression of the LcrV homolog, PcrV, in Pseudomonas aeruginosa...
  54. ncbi LuxS quorum sensing: more than just a numbers game
    Karina B Xavier
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Curr Opin Microbiol 6:191-7. 2003
    ..Studies suggest that AI-2 encodes information in addition to specifics about cell number...
  55. pmc A pro-drug approach for selective modulation of AI-2-mediated bacterial cell-to-cell communication
    Min Guo
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    Sensors (Basel) 12:3762-72. 2012
    ..Such differences could be utilized to selectively target QS in specific bacteria amongst a consortium of other species that also use AI-2 signaling...
  56. ncbi The methionine biosynthetic pathway from homoserine in Pseudomonas putida involves the metW, metX, metZ, metH and metE gene products
    M Alaminos
    Hospital Universitario Virgen de las Nieves, Servicio de Cirugia Pediatrica, Granada, Spain
    Arch Microbiol 176:151-4. 2001
    Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine...
  57. ncbi Cooperation of two distinct ExpR regulators controls quorum sensing specificity and virulence in the plant pathogen Erwinia carotovora
    Solveig Sjöblom
    Viikki Biocenter, Faculty of Biosciences, Department of Biological and Environmental Sciences, Division of Genetics, University of Helsinki, P O B 56, FIN 00014, Helsinki, Finland
    Mol Microbiol 60:1474-89. 2006
    ..These results suggest that Ecc is able to react both to the cognate AHSL signal and the signals produced by other bacterial species...
  58. ncbi Detection of autoinducer-2 and analysis of the profile of luxS and pfs transcription in Streptococcus suis serotype 2
    X G Han
    Key Lab Animal Disease Diagnostic and Immunology, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, China
    Curr Microbiol 58:146-52. 2009
    ..The results presented here demonstrate that SS2 can secrete AI-2 and that the profile of pfs transcription is highly correlated with the level of AI-2 production...
  59. ncbi Conjugation factor of Agrobacterium tumefaciens regulates Ti plasmid transfer by autoinduction
    K R Piper
    Department of Plant Pathology, University of Illinois, Urbana Champaign 61801
    Nature 362:448-50. 1993
    ....
  60. ncbi Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial
    Alan R Smyth
    Division of Child Health, University of Nottingham, Nottingham, UK
    Pediatr Pulmonol 45:356-62. 2010
    ..Garlic capsules were well tolerated. Although there was no significant effect of garlic compared to placebo in this pilot study, there was a suggestion of improvement with garlic which should be investigated in a larger trial...
  61. ncbi A proteomic analysis of Arabidopsis thaliana seedling responses to 3-oxo-octanoyl-homoserine lactone, a bacterial quorum-sensing signal
    Chunjuan Miao
    Biology Institute, Hebei Academy of Sciences, Shijiazhuang 050051, China
    Biochem Biophys Res Commun 427:293-8. 2012
    N-acyl-homoserine lactones (AHLs) are a class of bacterial quorum-sensing (QS) signals that are commonly used by Gram-negative bacteria for cell-to-cell communication...
  62. ncbi A multitask biosensor for micro-volumetric detection of N-3-oxo-dodecanoyl-homoserine lactone quorum sensing signal
    Francesco Massai
    Department of Biology, University Roma Tre, Viale G Marconi 446, 00146 Rome, Italy
    Biosens Bioelectron 26:3444-9. 2011
    N-3-oxo-dodecanoyl-homoserine lactone (3OC(12)-HSL) is the main quorum sensing (QS) signal produced by the human pathogen Pseudomonas aeruginosa, a major cause of hard-to-treat nosocomial infections and years-lasting chronic biofilm ..
  63. ncbi Identification of poultry meat-derived fatty acids functioning as quorum sensing signal inhibitors to autoinducer-2 (AI-2)
    K W Widmer
    Food Safety and Environmental Microbiology Program, Dept of Poultry Science and Nutrition and Food Science, Texas A and M Univ, College Station, TX 77843, USA
    J Food Sci 72:M363-8. 2007
    ..These fatty acids, through modulating quorum sensing by inhibition, may offer a unique means to control foodborne pathogens and reduce microbial spoilage...
  64. ncbi Temporal regulation of enterohemorrhagic Escherichia coli virulence mediated by autoinducer-2
    Tarun Bansal
    Artie McFerrin Department of Chemical Engineering, Texas A and M University, 222 Jack E Brown Engineering Building, 3122 TAMU, College Station, TX 77843 3122, USA
    Appl Microbiol Biotechnol 78:811-9. 2008
    ..Our results suggest that AI-2 is an important signal in EHEC infections of the human GI tract...
  65. pmc Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence
    Liping Zhao
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    Infect Immun 78:3506-15. 2010
    ..aureus. This regulation occurred via the phosphorylation of KdpE binding to the cap promoter...
  66. ncbi Quorum signaling via AI-2 communicates the "Metabolic Burden" associated with heterologous protein production in Escherichia coli
    M P Delisa
    Center for Agricultural Biotechnology, University of Maryland Biotechnological Institute, University of Maryland, College Park, MD, USA
    Biotechnol Bioeng 75:439-50. 2001
    ..Importantly, our findings demonstrate for the first time that recombinant E. coli communicate the stress or burden of overexpressing heterologous genes through the quorum-based AI-2 signaling pathway...
  67. ncbi The junctional integrity of epithelial cells is modulated by Pseudomonas aeruginosa quorum sensing molecule through phosphorylation-dependent mechanisms
    Elena Vikström
    Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Linkoping University, SE 58185 Linkoping, Sweden
    Exp Cell Res 315:313-26. 2009
    In Pseudomonas aeruginosa, cell-cell communication based on acyl-homoserine lactone (HSL) quorum sensing molecules is known to coordinate the production of virulence factors and biofilms by the bacterium...
  68. pmc Involvement of Shewanella oneidensis MR-1 LuxS in biofilm development and sulfur metabolism
    Deric R Learman
    Department of Geosciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Appl Environ Microbiol 75:1301-7. 2009
    ..Methionine is a key metabolite used in the AMC to produce a methyl source in the cell and to recycle homocysteine. These data suggest that LuxS is important to metabolizing methionine and the AMC in S. oneidensis...
  69. pmc The possible influence of LuxS in the in vivo virulence of rabbit enteropathogenic Escherichia coli
    Chengru Zhu
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vet Microbiol 125:313-22. 2007
    ..It appears that the luxS gene is not essential for in vivo pathogenicity by rEPEC where exogenous QS signals are present in the gut. The impact of AI-2 provided by multicopy plasmid on bacterial virulence is discussed...
  70. pmc Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli
    Liang Wang
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    J Bacteriol 187:2066-76. 2005
    ..coli. The elucidation of cAMP-CRP involvement in E. coli autoinduction impacts many areas, including the growth of E. coli in fermentation processes...
  71. pmc Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-Oxododecanoyl) homoserine lactone in NCI-H292 Cells
    Yoshifumi Imamura
    Second Department of Internal Medicine, School of Medicine, Nagasaki University, Nagasaki 852 8501, Japan
    Antimicrob Agents Chemother 48:3457-61. 2004
    ..The quorum-sensing signal molecule [N-(3-oxododecanoyl) homoserine lactone (3O-C(12)-HSL)] not only regulates bacterial virulence but also is associated with the immune response...
  72. pmc Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein
    João C Marques
    From the Instituto Gulbenkian de Ciência, 2780 Oeiras, Portugal
    J Biol Chem 286:18331-43. 2011
    ..Understanding of the biochemical mechanisms employed by bacteria to quench signaling of other species can be of great utility in the development of therapies to control bacterial behavior...
  73. pmc Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation
    Amanda L Garner
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 21:2702-5. 2011
    ....
  74. pmc Flow-based microfluidic device for quantifying bacterial chemotaxis in stable, competing gradients
    Derek L Englert
    Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, 77843 3122, USA
    Appl Environ Microbiol 75:4557-64. 2009
    ..Our data suggest that concentration-dependent interactions between attractant and repellent signals may be important determinants of bacterial colonization of the gut...
  75. pmc LsrR quorum sensing "switch" is revealed by a bottom-up approach
    Sara Hooshangi
    College of Professional Studies, The George Washington University, Washington, DC, United States of America
    PLoS Comput Biol 7:e1002172. 2011
    ..This "bottom up" approach in understanding gene regulation will serve to unravel complex QS network architectures and lead to the directed coordination of emergent behaviors...
  76. ncbi Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium
    T F Chin-A-Woeng
    Leiden University, Institute of Molecular Plant Sciences, The Netherlands
    Mol Plant Microbe Interact 14:969-79. 2001
    ..The main autoinducer molecule produced by PCL1391 was identified structurally as N-hexanoyl-L-homoserine lactone (C6-HSL)...
  77. pmc Helicobacter pylori perceives the quorum-sensing molecule AI-2 as a chemorepellent via the chemoreceptor TlpB
    Bethany A Rader
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    Microbiology 157:2445-55. 2011
    ..We conclude that H. pylori perceives LuxS-produced AI-2 as a chemorepellent via the chemoreceptor TlpB...
  78. ncbi Quorum sensing in Cyanobacteria: N-octanoyl-homoserine lactone release and response, by the epilithic colonial cyanobacterium Gloeothece PCC6909
    Dilara I Sharif
    Department of Environmental and Molecular Biosciences, SOTEAS, Swansea University, Swansea, UK
    ISME J 2:1171-82. 2008
    Quorum sensing involving acyl homoserine lactones (AHLs) is a density-dependent form of intercellular communication that occurs in many different members of the group Proteobacteria...
  79. ncbi Small molecule inhibitors of bacterial quorum sensing and biofilm formation
    Grant D Geske
    Department of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA
    J Am Chem Soc 127:12762-3. 2005
    ..Here, we report a new and efficient synthetic route to naturally occurring bacterial autoinducers [N-acyl l-homoserine lactones (AHLs)] that is readily amenable to the synthesis of analogues...
  80. ncbi Dynamic regulation of N-acyl-homoserine lactone production and degradation in Pseudomonas putida IsoF
    Agnes Fekete
    Institute of Ecological Chemistry, Helmholtz Zentrum Munchen, Neuherberg, Germany
    FEMS Microbiol Ecol 72:22-34. 2010
    The biocontrol strain Pseudomonas putida IsoF, which was isolated from a tomato rhizosphere, is a known N-acyl-homoserine lactone (AHL) producer with only one LuxI/LuxR-like quorum-sensing (QS) system...
  81. pmc What's in a name? The semantics of quorum sensing
    Thomas G Platt
    Department of Biology, Indiana University, Jordan Hall, 1001 East Third Street, Bloomington, IN 47405 3700, USA
    Trends Microbiol 18:383-7. 2010
    ..In fact, the ecological context of QS regulation, like the process itself, is complex and impacted by multiple aspects of natural environments...
  82. ncbi The luxS gene is involved in AI-2 production, pathogenicity, and some phenotypes in Erwinia amylovora
    Yan Gao
    College of Plant Protection, Key Laboratory of Monitoring and Management of Plant Diseases and Insects, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, 210095, China
    Curr Microbiol 58:1-10. 2009
    ..Inactivation of luxS in Ea1665 impaired motility, extracellular polysaccharide (EPS) production, and tolerance for hydrogen peroxide, and reduced virulence on pear leaves...
  83. ncbi AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ
    Gilles Brackman
    Laboratory of Pharmaceutical Microbiology, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Microbiology 155:4114-22. 2009
    ..anguillarum, and to protect gnotobiotic Artemia from V. harveyi-induced mortality...
  84. pmc Stationary-phase quorum-sensing signals affect autoinducer-2 and gene expression in Escherichia coli
    Dacheng Ren
    Department of Chemical Engineering, University of Connecticut, Storrs, Connecticut 06269 3222, USA
    Appl Environ Microbiol 70:2038-43. 2004
    ..coli K-12 AI-2 concentrations by 4.8-fold +/- 0.4-fold, suggesting that an additional quorum-sensing system in E. coli exists and that gene expression is controlled as a network with different signals working at different growth stages...
  85. pmc Quorum sensing-disrupting brominated furanones protect the gnotobiotic brine shrimp Artemia franciscana from pathogenic Vibrio harveyi, Vibrio campbellii, and Vibrio parahaemolyticus isolates
    Tom Defoirdt
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Appl Environ Microbiol 72:6419-23. 2006
    ..Furthermore, disruption of AI-2 quorum sensing by a natural and a synthetic brominated furanone protected gnotobiotic Artemia from the pathogenic isolates in in vivo challenge tests...
  86. ncbi Cross species quorum quenching using a native AI-2 processing enzyme
    Varnika Roy
    Department of Molecular and Cell Biology, University of Maryland, College Park, Maryland 20742, USA
    ACS Chem Biol 5:223-32. 2010
    ..We believe this nature-inspired enzymatic approach for quenching QS systems will spawn new methods for controlling cell phenotype and potentially open new avenues for controlling bacterial pathogenicity...
  87. pmc Quorum sensing and production of autoinducer-2 in Campylobacter spp., Escherichia coli O157:H7, and Salmonella enterica serovar Typhimurium in foods
    Orla M Cloak
    Eastern Regional Research Center, Agricultural Research Service, U S Department of Agriculture, Wyndmoor, Pennsylvania 19038, USA
    Appl Environ Microbiol 68:4666-71. 2002
    ..coli, C. jejuni, Salmonella enterica serovar Typhimurium, and Escherichia coli O157:H7 under different conditions...
  88. pmc Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone
    John F Teiber
    The University of Texas Southwestern Medical Center, Department of Internal Medicine, Division of Epidemiology, 5323 Harry Hines Blvd, Dallas, TX 75390 8874, USA
    Infect Immun 76:2512-9. 2008
    ..N-(3-oxododecanoyl)-L-homoserine lactone (3OC12-HSL) is a key component of P...
  89. pmc The Crp-activated small noncoding regulatory RNA CyaR (RyeE) links nutritional status to group behavior
    Nicholas De Lay
    Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892 4264, USA
    J Bacteriol 191:461-76. 2009
    ..These results provide insight into the mechanisms by which Crp negatively regulates genes such as luxS and ompX and provide a link between catabolite repression, quorum sensing, and nitrogen assimilation in E. coli...
  90. ncbi Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia
    David A Stoltz
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, 440 EMRB, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 292:L852-60. 2007
    ..N-3-oxododecanoyl homoserine lactone (3OC12-HSL) is the major autoinducer in P. aeruginosa...
  91. pmc The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells
    Matthew L Mayer
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    PLoS ONE 6:e16246. 2011
    ..The Pseudomonas aeruginosa quorum sensing autoinducer N-3-oxododecanoyl homoserine lactone (3O-C12) is an important bacterial virulence factor that has been reported to induce proinflammatory ..
  92. ncbi Influence of Pseudomonas aeruginosa quorum sensing signal molecule N-(3-oxododecanoyl) homoserine lactone on mast cells
    Hongtao Li
    Department of Infectious Diseases, Tongji Hospital, Wuhan, China
    Med Microbiol Immunol 198:113-21. 2009
    ..Recent advances have demonstrated that the Pseudomonas aeruginosa quorum sensing molecule, N-3-oxododecanoyl homoserine lactone (3OC(12)-HSL), exerts effects on mammalian cells and modulates host immune response...
  93. ncbi Immune modulation by Pseudomonas aeruginosa quorum-sensing signal molecules
    David Idris Pritchard
    Immune Modulation Research Group, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Int J Med Microbiol 296:111-6. 2006
    ..aeruginosa) at levels which might be expected to modify immune competence, the true impact of bacterial QSSMs on host physiology in vivo has yet to be fully determined...
  94. ncbi The immunomodulatory Pseudomonas aeruginosa signalling molecule N-(3-oxododecanoyl)-L-homoserine lactone enters mammalian cells in an unregulated fashion
    Adam J Ritchie
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Immunol Cell Biol 85:596-602. 2007
    The Pseudomonas aeruginosa quorum-sensing signal molecule N-3-oxododecanoyl)-L-homoserine lactone (OdDHL) has been reported to affect the function of a wide range of mammalian cell types, including cells of the immune system...
  95. ncbi Pseudomonas signal molecule 3-oxo-C12-homoserine lactone interferes with binding of rosiglitazone to human PPARgamma
    Margaret A Cooley
    Menzies Research Institute, University of Tasmania, Private Bag 73, Hobart TAS 7000, Australia
    Microbes Infect 12:231-7. 2010
    ..However, the P. aeruginosa signal molecule N-(3-oxo-dodecanoyl)-l-homoserine lactone (3-oxo-C12-HSL) has been reported to inhibit function of PPARs in mammalian cells...
  96. pmc Functional analysis of the group A streptococcal luxS/AI-2 system in metabolism, adaptation to stress and interaction with host cells
    Maria Siller
    University of Vienna, Department of Microbiology and Immunobiology, 1030 Vienna, Austria
    BMC Microbiol 8:188. 2008
    ....
  97. ncbi Bacterial quorum sensing: a new target for anti-infective immunotherapy
    Gunnar F Kaufmann
    Skaggs Institute for Chemical Biology, Department of Chemistry and Immunology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Expert Opin Biol Ther 8:719-24. 2008
    ..The discovery that Gram-negative bacteria employ non-peptide structures, N-acyl homoserine lactones, to globally regulate production of secondary metabolites and proteins, initiated a new area of ..
  98. pmc Modification of in vivo and in vitro T- and B-cell-mediated immune responses by the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone
    Adam J Ritchie
    School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia 2052
    Infect Immun 71:4421-31. 2003
    N-3-(oxododecanoyl)-L-homoserine lactone (OdDHL), a quorum-sensing molecule of Pseudomonas aeruginosa, plays an important role in the pathogenesis of the organism through its control of virulence factor expression...
  99. pmc Autoinducer-2 production in Campylobacter jejuni contributes to chicken colonization
    Beatriz Quiñones
    U S Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Produce Safety and Microbiology Research Unit, 800 Buchanan Street, Albany, CA 94710, USA
    Appl Environ Microbiol 75:281-5. 2009
    ..Thus, AI-2 production in C. jejuni contributes to host colonization and interactions with epithelial cells...
  100. ncbi Uneven distribution of the luxS gene within the genus Campylobacter
    A Tazumi
    Laboratory of Molecular Biology, School of Environmental Health Sciences, Azabu University, Sagamihara, Japan
    Br J Biomed Sci 68:19-22. 2011
    ..In addition, a biofilm formation assay demonstrated that biofilm formation in the C. lari species does not appear to correlate with the occurrence of the luxS gene because biofilm formation occurred among some isolates of C. lari...
  101. ncbi The Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl) homoserine lactone can accelerate cutaneous wound healing through myofibroblast differentiation in rats
    Gojiro Nakagami
    Department of Gerontological Nursing Wound Care Management, Graduate School of Medicine, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    FEMS Immunol Med Microbiol 62:157-63. 2011
    Quorum sensing is a cell density-dependent gene regulation system in bacteria. N-(3-oxododecanoyl) homoserine lactone (3-oxo-C12-HSL) is used in the las quorum-sensing system in Pseudomonas aeruginosa, which is an opportunistic pathogen ..

Research Grants50

  1. Bacterial Immunosuppression: Host Target Identification Through Chemical Probes
    Kim D Janda; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In Gram-negative bacteria N-acyl-L-homoserine lactones (AHLs) are produced as quorum-sensing (QS) signaling molecules to promote multicellularity and virulence...
  2. Re-Wiring Cellular Metabolism to Control Biofilm Formation and Virulence BY...
    Thomas K Wood; Fiscal Year: 2011
    ..We have recently discovered that E. coli and pseudomonads respond to signals they do not synthesize (homoserine lactones influence E...
  3. Molecular Basis of Bacterial Quorum Sensing Gene Regulation
    MAIR E CHURCHILL; Fiscal Year: 2010
    ..The virulence of P. aeruginosa, as well as other gram-negative human pathogens, requires an acyl-homoserine lactone (AHL) dependent quorum-sensing system. In addition to well-known gene-regulatory AHL receptors in P...
  4. INTERACTIONS BETWEEN AGROBACTERIUM AND HOST PLANTS
    Stephen C Winans; Fiscal Year: 2010
    ..Among these signals, acyl-homoserine lactones (AHLs) are especially widespread among the proteobacteria...
  5. Biological Implications of Tetramic Acid
    Kim D Janda; Fiscal Year: 2010
    ..Two different AHLs, N-(3-oxododecanoyl) homoserine lactone (3-oxo- C12-HSL), synthesized by LasI, and N-butyrylhomoserine lactone (C4-HSL), synthesized by RhlI, ..
  6. Bacterial Quorum Sensing as Target for Anti-Infective Immunotherapy
    Bin Zhou; Fiscal Year: 2013
    ..bacteria, such as Vibrio fischeri and Pseudomonas aeruginosa, employ small diffusible molecules, namely N-acyl homoserine lactones, to globally regulate the production of secondary metabolites and proteins, initiated a new area in ..
  7. Small Molecule Inhibitors of P. aeruginosa Quinolone (Pqs) Quorum Sensing
    Derek S Tan; Fiscal Year: 2013
    ..This is a pharmacologically validated target in a mouse model of infection and is distinct from acyl homoserine lactone (Las, Rhl) quorum sensing systems...
  8. Chemical Tools to Delineate the Pseudomonas aeruginosa Quorum Sensing Circuit
    Nora R Eibergen; Fiscal Year: 2013
    ..bacteria, this QS process is largely driven by the detection of structurally distinct N-acylated L- homoserine lactones (AHLs)...
  9. Eukaryotic Perception of Prokaryotic Quorum Signals
    ANDREW GEORGE PALMER; Fiscal Year: 2010
    ..The best characterized Als are the N-acylated L-homoserine lactones (AHLs) utilized by Gram-negative bacteria...
  10. SdiA regulation of EHEC virulence
    Vanessa Sperandio; Fiscal Year: 2013
    ..SdiA is a quorum sensing transcription factor that requires its autoinducer, an acyl-homoserine lactone (AHL) for proper folding and function...
  11. Studies of bacterial autoinducers:recognition and modulation of host processes
    Vladimir V Kravchenko; Fiscal Year: 2012
    ..in the field of host-pathogen interactions mediated by quorum sensing signaling molecules (QSSM), namely acyl homoserine lactones (AHLs)...
  12. Developing Inhibitors of LuxS-dependent Quorum Sensing Systems in Oral Bacteria
    Chunhao Li; Fiscal Year: 2013
    ..There are two major types of AIs, AI-1 and AI-2. AI-1 includes acylated homoserine lactones and modified peptides, which serve as intra-species signaling molecules...
  13. QUORUM SENSING IN PSEUDOMONAS AERUGINOSA
    Everett P Greenberg; Fiscal Year: 2013
    ..This research program is focused on P. aeruginosa, which controls a battery of virulence factors by acyl-homoserine lactone quorum sensing...
  14. Chemical Strategies to Manipulate A1-2 Signaling in Bacterial Pathogens
    Kim D Janda; Fiscal Year: 2013
    ..g. oligopeptides and acyl homoserine lactones, have been identified as autoinducers...
  15. 3rd ASM Conference on Cell-Cell Communication in Bacteria
    WILLIAM FUQUA; Fiscal Year: 2007
    ..systems such as the cyclic oligopeptide signals that regulate Staphylococcus aureus virulence and acyl homoserine lactones (AHLs) that control of pathogenesis in Pseudomonas aeruginosa are now joined by a number of more ..
  16. Quorum Sensing in Sinorhizobium meliloti
    Juan Gonzalez; Fiscal Year: 2009
    ..The best characterized of these autoinducers are acylated homoserine lactones (AHLs), mostly found in gram-negative organisms...
  17. MOLECULAR MECHANISM OF REGULATION OF THE LUX REGULON
    Thomas Baldwin; Fiscal Year: 1991
    ..protein, LuxR, the sole gene product of the left operon, and a small molecule effector, N-(3-oxohexanoyl)homoserine lactone, or "autoinducer"...
  18. Structural Basis for Bridged Bimetallic Enzyme Catalysis
    Dagmar Ringe; Fiscal Year: 2009
    ..In addition, since we have just solved the structure of a bacterial quorum-sensing acyl-homoserine lactone hydrolase, we will carry out similar experiments and calculations on this dizinc enzyme, which has an ..
  19. Enzymology of Homoserine Acylation in Methionine Biosynt
    TIMOTHY BORN; Fiscal Year: 2003
    ..The first unique step in methionine biosynthesis, acylation of the g-hydroxyl of homoserine, controls flux of homoserine into the pathway...
  20. Quorum Sensing in Burkholderia mallei
    Josephine R Chandler; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cell-cell communication by acyl-homoserine lactone (acyl-HSL) quorum sensing (QS) is common to a variety of Gram-negative Proteobacteria and regulates diverse biological functions...
  21. Generating antibodies against N-Acyl homoserine lactones
    Kim Janda; Fiscal Year: 2004
    The discovery that Gram-negative bacteria employ small molecules, namely N-acyl homoserine lactones (AHLs), to globally regulate the production of secondary metabolites and control the expression of virulence determinants has provided a ..
  22. STRUCTURE AND MECHANISM OF L-ASPARTASE
    RONALD VIOLA; Fiscal Year: 1990
    ..The bifunctional enzyme aspartokinase- homoserine dehydrogenase also occupies a key position in metabolism, the commitment step to the biosynthesis of four amino ..
  23. QUORUM SENSING IN HUMAN CELLS
    BRUCE DOLNICK; Fiscal Year: 2002
    ..Quorum sensing depends upon the secretion and sensing of species-specific nonpolar signal molecules (acyl homoserine lactones, acyl-HSLs) that arise from the metabolism of methionine...
  24. QUORUM SENSING IN HUMAN CELLS
    BRUCE DOLNICK; Fiscal Year: 2003
    ..Quorum sensing depends upon the secretion and sensing of species-specific nonpolar signal molecules (acyl homoserine lactones, acyl-HSLs) that arise from the metabolism of methionine...
  25. SMALL BIOEFFECTOR MOLECULES OF STREPTOCOCCUS MUTANS
    Jeffrey Hillman; Fiscal Year: 2001
    ..In the course of identifying this activity, we also identified two N-acyl-L-homoserine lactone (AHSL)-like compounds, which are molecules involved in quorum sensing in Gram negative bacteria and ..
  26. Quorum sensing, bacterial interaction and disease
    Naomi Balaban; Fiscal Year: 2004
    ..by quorum sensing mechanisms, through the secretion of signaling organic molecules such as derivatives of homoserine lactones in Gram-negative bacteria and proteins and peptides in Gram-positive bacteria to activate or suppress ..
  27. STEREOCHEMICAL MECHANISM OF SICKLING OF HEMOGLOBIN S
    JEN YANG; Fiscal Year: 1980
    ..Certain amino acids such as L-homoserine have been reported to inhibit the sickling of sickle cells...
  28. Structural studies of bacterial quorum sensing regulator
    Mair Churchill; Fiscal Year: 2005
    ..III) Establish whether the AHL-synthase homologues in divergent organisms produce a homoserine lactone signal using mass spectrometry and activity assays...
  29. Crystallographic Analysis of GHMP kinases
    Hong Zhang; Fiscal Year: 2005
    ..contains more than 170 proteins, representing about 12-13 different functions, including galactokinases, homoserine kinases, mevalonate kinases, phosphomevalonate kinases (hence GHMP), mevalonate diphosphate decarboxylase, ..
  30. rTS Signaling Mimetics As Novel Cancer Therapeutics
    Jie Wang; Fiscal Year: 2006
    ..Dr. Dolnick and his collaborators have since identified an agent (3-oxododecanoyl homoserine lactone, or 3-oxo-C12-HSL, or OHL) that acts through this pathway and enhances the activity of TS inhibitors, in ..
  31. Bacterial AHL interactions with nuclear receptors
    BARRY FORMAN; Fiscal Year: 2005
    ..Gram-negative bacteria release small molecules called acyl homoserine lactones (AHLs) into the surrounding environment to communicate within and between species...
  32. Small Molecule Inhibitor of Quorum Sensing
    Susan Wright; Fiscal Year: 2004
    The opportunistic human pathogen, Pseudomonas aeruginosa, utilizes acyl-homoserine lactones (acyI-HSL) as quorum sensing autoinducers to activate the expression of numerous virulence genes...
  33. IasB is Essential for Surface Motility in P. aeruginosa
    JAYNE ROBINSON; Fiscal Year: 2004
    ..The number and position of flagella are altered on lasB mutant cells. Additionally, lesser amounts of C4-homoserine lactone (HSL) are produced by lasB mutant cells...
  34. EHEC interactions with the normal intestinal flora
    Vanessa Sperandio; Fiscal Year: 2004
    ..In Specific Aim 2, we propose to monitor EHEC virulence gene expression in a mixed population in the presence of the intestinal flora. ..
  35. Transcriptional Profiles of Escherichia coli Biofilms
    Robert McLean; Fiscal Year: 2002
    ..Overall, this project will explain several fundamental aspects of E. coli biofilm growth and suggest possible targets for future antibiotic research. ..
  36. Screen for Quorum Sensing Molecular Inhibitors (RMI)
    Vanessa Sperandio; Fiscal Year: 2005
    ....
  37. DbpA/B proteins of Borrelia burgdorferi & Lyme arthritis
    Nikhat Parveen; Fiscal Year: 2005
    ..This study will characterize the role of two spirochete lipoprotein adhesins in Lyme arthritis in the murine model. ..
  38. Proteogenome of Anaerobic P. aeruginosa in CF Mucus
    DANIEL HASSETT; Fiscal Year: 2003
    ..Our LONG TERM GOAL is to identify cellular targets that inhibit or significantly compromise the denitrification process that is occurring by P. aeruginosa in the CF airways. ..
  39. IRON, FUR AND ALGINATE PRODUCTION IN P AERUGINOSA
    DANIEL HASSETT; Fiscal Year: 2002
    ..Information derived from the studies proposed herein will advance the current knowledge about the role of these factors in the pathogenesis of P. aeruginosa infections in CF. ..
  40. MOLECULAR GENETICS OF ENTEROPATHOGENIC E COLI ADHESION
    JAMES KAPER; Fiscal Year: 2003
    ..The proposed experimental approach will use a combination of molecular genetics, cell biology, and animal studies to achieve a better understanding of how EPEC infects intestinal epithelial cells and causes disease. ..
  41. B.pseudomallei bioterrorism and quorum sensing
    DANIEL HASSETT; Fiscal Year: 2003
    ..These studies will provide important information that will lead to countermeasures against a potential bioterrorist attack using the potentially lethal gram-negative bacterium, B. pseudomallei. ..
  42. Mechanism and Engineering of an Autoinducer Hydrolase
    Walter Fast; Fiscal Year: 2004
    ..An important trigger for biofilm formation is the secretion and detection of N-acyl-homoserine lactones, also called autoinducers (AIs)...
  43. Detection of Mixed Microbial Communities by Salmonella
    BRIAN AHMER; Fiscal Year: 2004
    ..We will use microarrays to identify the portions of the E. coli and S. typhimurium genomes that are regulated by SdiA in response to AHLs and characterize the phenotypic consequences of this signaling event. ..
  44. NOVEL E. COLI 0157:H7 INTESTINAL COLONIZATION FACTORS
    JAMES KAPER; Fiscal Year: 2009
    ....
  45. Deciphering how glycosylation protects peptides from proteolysis
    Michael Carrasco; Fiscal Year: 2007
    ..Understanding and using how attaching sugars to peptides protects them from digestion would enable the creation of new classes of powerful peptide pharmaceuticals. [unreadable] [unreadable] [unreadable]..
  46. Optimization of Membrane Protein Biogenesis
    AARON LINK; Fiscal Year: 2007
    ..coli will be developed. Such a platform will be of great utility to researchers interested in the structural and biochemical properties of membrane proteins. [unreadable] [unreadable] [unreadable]..
  47. Role of OxyR in P. aeruginosa Biofilm Resistance to H202
    DANIEL HASSETT; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  48. Cell-To-Cell Signaling in Bacterial Biofilms
    DAVID CHOPP; Fiscal Year: 2006
    ..Experimental results will be used to refine the mathematical models. ..
  49. DEVELOPMENT OF A LIVE ORAL CHOLERA VACCINE
    James B Kaper; Fiscal Year: 2010
    ..Lay summary: Vibrio cholerae is a bacterium that causes cholera, a severe diarrheal disease that can often cause death. This project will develop improved vaccines for the prevention of cholera. ..